(en)The present invention relates to aminotetraline derivatives of the formula (I)









or a physiologically tolerated salt thereof.
The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of such aminotetraline derivatives for therapeutic purposes. The aminotetraline derivatives are GlyT1 inhibitors.

1.ApplicationNumber: US-70632610-A
1.PublishNumber: US-2010273739-A1
2.Date Publish: 20101028
3.Inventor: AMBERG WILHELM
OCHSE MICHEAL
LANGE UDO
KING ANDREAS
BEHL BERTHOLD
HAMBERGER WILFRIED
MEZIER MARIC
HUTCHINS CHARLES W.

4.Inventor Harmonized: AMBERG WILHELM(DE)
OCHSE MICHEAL(DE)
LANGE UDO(DE)
KING ANDREAS(DE)
BEHL BERTHOLD(DE)
HAMBERGER WILFRIED(DE)
MEZIER MARIC(DE)
HUTCHINS CHARLES W(US)

5.Country: US
6.Claims:
(en)The present invention relates to aminotetraline derivatives of the formula (I)









or a physiologically tolerated salt thereof.
The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of such aminotetraline derivatives for therapeutic purposes. The aminotetraline derivatives are GlyT1 inhibitors.

7.Description:
(en)CROSS-REFERENCE TO RELATED APPLICATIONS
This claims the benefit of U.S. Provisional Application No. 61/152,825, which was filed on Feb. 16, 2009, the contents of which are incorporated herein by reference.


FIELD OF THE INVENTION
The present invention relates to aminotetraline derivatives, pharmaceutical compositions comprising such aminotetraline derivatives, and the use of such aminotetraline derivatives for therapeutic purposes. The aminotetraline derivatives are GlyT1 inhibitors.
BACKGROUND OF THE INVENTION
Dysfunction of glutamatergic pathways has been implicated in a number of disease states in the human central nervous system (CNS) including but not limited to schizophrenia, cognitive deficits, dementia, Parkinson disease, Alzheimer disease and bipolar disorder. A large number of studies in animal models lend support to the NMDA hypofunction hypothesis of schizophrenia.
NMDA receptor function can be modulated by altering the availability of the co-agonist glycine. This approach has the critical advantage of maintaining activity-dependent activation of the NMDA receptor because an increase in the synaptic concentration of glycine will not produce an activation of NMDA receptors in the absence of glutamate. Since synaptic glutamate levels are tightly maintained by high affinity transport mechanisms, an increased activation of the glycine site will only enhance the NMDA component of activated synapses.
Two specific glycine transporters, GlyT1 and GlyT2 have been identified and shown to belong to the Na/Cl-dependent family of neurotransmitter transporters which includes taurine, gamma-aminobutyric acid (GABA), proline, monoamines and orphan transporters. GlyT1 and GlyT2 have been isolated from different species and shown to have only 50% identity at the amino acid level. They also have a different pattern of expression in mammalian central nervous system, with GlyT2 being expressed in spinal cord, brainstem and cerebellum and GlyT1 present in these regions as well as forebrain areas such as cortex, hippocampus, septum and thalamus. At the cellular level, GlyT2 has been reported to be expressed by glycinergic nerve endings in rat spinal cord whereas GlyT1 appears to be preferentially expressed by glial cells. These expression studies have led to the suggestion that GlyT2 is predominantly responsible for glycine uptake at glycinergic synapses whereas GlyT1 is involved in monitoring glycine concentration in the vicinity of NMDA receptor expressing synapses. Recent functional studies in rat have shown that blockade of GlyT1 with the potent inhibitor (N-[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl])-sarcosine (NFPS) potentiates NMDA receptor activity and NMDA receptor-dependent long-term potentiation in rat.
Molecular cloning has further revealed the existence of three variants of GlyT1, termed GlyT-1a, GlyT-1b and GlyT-1c, each of which displays a unique distribution in the brain and peripheral tissues. The variants arise by differential splicing and exon usage, and differ in their N-terminal regions.
The physiological effects of GlyT1 in forebrain regions together with clinical reports showing the beneficial effects of GlyT1 inhibitor sarcosine in improving symptoms in schizophrenia patients suggest that selective GlyT1 inhibitors represent a new class of antipsychotic drugs.
Glycine transporter inhibitors are already known in the art, for example:



















































(see also Hashimoto K., Recent Patents on CNS Drug Discovery, 2006, 1, 43-53; Harsing L. G. et al., Current Medicinal Chemistry, 2006, 13, 1017-1044; Javitt D. C., Molecular Psychiatry (2004) 9, 984-997; Lindsley, C. W. et al., Current Topics in Medicinal Chemistry, 2006, 6, 771-785; Lindsley C. W. et al., Current Topics in Medicinal Chemistry, 2006, 6, 1883-1896).
It was one object of the present invention to provide further glycine transporter inhibitors.
SUMMARY OF THE INVENTION
The present invention relates to aminotetraline derivatives of the formula (I)











wherein


A is a 5- or 6-membered ring;
R is R 1 —W-A 1 -Q-Y-A 2 -X 1 —;
R 1 is hydrogen, alkyl, cycloalkylalkyl, halogenated alkyl, trialkylsilylalkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkylcarbonylaminoalkyl, alkyloxycarbonylaminoalkyl, alkylaminocarbonylaminoalkyl, dialkylaminocarbonylaminoalkyl, alkylsulfonylaminoalkyl, (optionally substituted arylalkyl), aminoalkyl, optionally substituted arylalkyl, optionally substituted heterocyclylalkyl, cycloalkyl, alkylcarbonyl, alkoxycarbonyl, halogenated alkoxycarbonyl, aryloxycarbonyl, aminocarbonyl, alkylaminocarbonyl, (halogenated alkyl)aminocarbonyl, arylaminocarbonyl, alkenyl, alkynyl, optionally substituted aryl, hydroxy, alkoxy, halogenated alkoxy, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, alkylaminoalkoxy, dialkylaminoalkoxy, alkylcarbonylaminoalkoxy, arylcarbonylaminoalkoxy, alkoxycarbonylaminoalkoxy, arylalkoxy, alkylsulfonylaminoalkoxy, (halogenated alkyl)sulfonylaminoalkoxy, arylsulfonylaminoalkoxy, (arylalkyl)sulfonylaminoalkoxy, heterocyclylsulfonylaminoalkoxy, heterocyclylalkoxy, aryloxy, heterocyclyloxy, alkylthio, halogenated alkylthio, alkylamino, (halogenated alkyl)amino, dialkylamino, di-(halogenated alkyl)amino, alkylcarbonylamino, (halogenated alkyl)carbonylamino, arylcarbonylamino, alkylsulfonylamino, (halogenated alkyl)sulfonylamino, arylsulfonylamino or optionally substituted heterocyclyl;
W is —NR 8 — or a bond;
A 1 is optionally substituted alkylene or a bond;
Q is —S(O) 2 — or —C(O)—;
Y is —NR 9 — or a bond;
A 2 is optionally substituted alkylene, alkylene-CO—, —CO-alkylene, alkylene-O-alkylene, alkylene-NR 18 -alkylene, optionally substituted alkenylen, optionally substituted alkynylene, optionally substituted arylene, optionally substituted heteroarylene or a bond;
X 1 is —O—, —NR 11 —, —S—, optionally substituted alkylene, optionally substituted alkenylen, optionally substituted alkynylene;
R 2 is hydrogen, halogen, alkyl, halogenated alkyl, hydroxyalkyl, —CN, alkenyl, alkynyl, optionally substituted aryl, hydroxy, alkoxy, halogenated alkoxy, alkoxycarbonyl, alkenyloxy, arylalkoxy, alkylcarbonyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aminosulfonyl, amino, alkylamino, alkenylamino, nitro or optionally substituted heterocyclyl, or two radicals R 2 together with the ring atoms of A to which they are bound form a 5- or 6-membered ring;
R 3 is hydrogen, halogen, alkyl or alkoxy, or two radicals R 3 together with the carbon atom to which they are attached form a carbonyl group;
R 4a is hydrogen, alkyl, cycloalkylalkyl, halogenated alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, CH 2 CN, —CHO, alkylcarbonyl, (halogenated alkyl)carbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, alkenyl, —C(═NH)NH 2 , —C(═NH)NHCN, alkylsulfonyl, arylsulfonyl, amino, —NO or heterocyclyl;
R 4b is hydrogen, alkyl, halogenated alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, CH 2 CN, —CHO, alkylcarbonyl, (halogenated alkyl)carbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, alkenyl, —C(═NH)NH 2 , —C(═NH)NHCN, alkylsulfonyl, arylsulfonyl, amino, —NO or heterocyclyl; or
R 4a , R 4b
together are optionally substituted alkylene, wherein one —CH 2 — of alkylene may be replaced by an oxygen atom or —NR 16 ;

X 2 is —O—, —NR 6 —, —S—, >CR 12a R 12b or a bond;
X 3 is —O—, —NR 7 —, —S—, >CR 13a R 13b or a bond;
R 5 is optionally substituted aryl, optionally substituted cycloalkyl or optionally substituted heterocyclyl;
n is 0, 1 or 2;
R 6 is hydrogen or alkyl;
R 7 is hydrogen or alkyl;
R 9 is hydrogen or alkyl;
R 9 is hydrogen, alkyl, cycloalkyl, aminoalkyl, optionally substituted arylalkyl or heterocyclyl; or
R 9 , R 1
together are alkylene; or

R 9 is alkylene that is bound to a carbon atom in A 2 and A 2 is alkylene or to a carbon atom in X 1 and X 1 is alkylene;
R 10 is hydrogen, alkyl or alkylsulfonyl;
R 11 is hydrogen or alkyl, or
R 9 , R 11
together are alkylene,

R 12a is hydrogen, optionally substituted alkyl, alkylaminoalkyl, dialkylaminoalkyl, heterocyclylalkyl, optionally substituted aryl or hydroxy;
R 12b is hydrogen or alkyl, or
R 12a , R 12b
together are carbonyl or optionally substituted alkylene, wherein one —CH 2 — of alkylene may be replaced by an oxygen atom or —NR 14 —;

R 13a is hydrogen, optionally substituted alkyl, alkylaminoalkyl, dialkylaminoalkyl, heterocyclylalkyl, optionally substituted aryl or hydroxy;
R 13b is hydrogen or alkyl, or
R 13a , R 13b
together are carbonyl or optionally substituted alkylene, wherein one —CH 2 — of alkylene may be replaced by an oxygen atom or —NR 15 —;

R 14 is hydrogen or alkyl;
R 15 is hydrogen or alkyl; and
R 16 is hydrogen or alkyl,

or a physiologically tolerated salt thereof.



Thus, the present invention relates to aminotetraline derivatives having the formula (Ia)









wherein A, R 1 , W, A 1 , Q, Y, A 2 , X 1 , R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
Further, the present invention relates to aminotetraline derivatives of formula (I) wherein R is —CN, i.e. aminotetraline derivatives having the formula (Ib)









wherein A, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
Thus, the term aminotetraline derivative is used herein to denote in particular aminotetralines (n=1) and fused cyclohexanes (n=1) wherein the benzene ring is replaced by a 5- or 6-membered heterocyclic ring as well as homologous bicyclic compounds wherein n is 0 or 2.
Said compounds of formula (I), i.e., the aminotetraline derivatives of formula (I) and their physiologically tolerated acid addition salts, are glycine transporter inhibitors and thus useful as pharmaceuticals.
The present invention thus further relates to the compounds of formula (I) for use in therapy.
The present invention also relates to pharmaceutical compositions which comprise a carrier and a compound of formula (I).
In particular, said compounds, i.e., the aminotetraline derivatives and their physiologically tolerated acid addition salts, are inhibitors of the glycine transporter GlyT1.
The present invention thus further relates to the compounds of formula (I) for use in inhibiting the glycine transporter.
The present invention also relates to the use of the compounds of formula (I) in the manufacture of a medicament for inhibiting the glycine transporter GlyT1 and corresponding methods of inhibiting the glycine transporter GlyT1.
Glycine transport inhibitors and in particular inhibitors of the glycine transporter GlyT1 are known to be useful in treating a variety of neurologic and psychiatric disorders.
The present invention thus further relates to the compounds of formula (I) for use in treating a neurologic or psychiatric disorder.
The present invention further relates to the compounds of formula (I) for use in treating pain.
The present invention also relates to the use of the compounds of formula (I) in the manufacture of a medicament for treating a neurologic or psychiatric disorder and corresponding methods of treating said disorders. The present invention also relates to the use of the compounds of formula (I) in the manufacture of a medicament for treating pain and corresponding methods of treating pain.
The present invention further relates to aminotetraline derivatives of formula (II)









wherein L is an amino-protecting group, Y is NR 9 , and A 2 , X 1 , R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n and R 9 are defined as above.
The aminotetraline derivatives of formula (II) are useful as intermediates in the preparation of GlyT1 inhibitors, in particular those of formula (I).


DETAILED DESCRIPTION OF THE INVENTION
Provided that the aminotetraline derivatives of the formula (I) or (II) of a given constitution may exist in different spatial arrangements, for example if they possess one or more centers of asymmetry, polysubstituted rings or double bonds, or as different tautomers, it is also possible to use enantiomeric mixtures, in particular racemates, diastereomeric mixtures and tautomeric mixtures, preferably, however, the respective essentially pure enantiomers, diastereomers and tautomers of the compounds of formula (I) or (II) and/or of their salts.
According to one embodiment, an enantiomer of the aminotetraline derivatives of the present invention has the following formula:









wherein A, R, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
According to another embodiment, an enantiomer of the aminotetraline derivatives of the present invention has the following formula:









wherein A, R, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
According to one embodiment, an enantiomer of the aminotetraline derivatives of the present invention has the following formula:









wherein A, R, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
According to another embodiment, an enantiomer of the aminotetraline derivatives of the present invention has the following formula:









wherein A, R, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
The physiologically tolerated salts of the aminotetraline derivatives of the formula (I) or (II) are especially acid addition salts with physiologically tolerated acids. Examples of suitable physiologically tolerated organic and inorganic acids are hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid, C 1 -C 4 -alkylsulfonic acids, such as methanesulfonic acid, cycloaliphatic sulfonic acids, such as S-(+)-10-campher sulfonic acid, aromatic sulfonic acids, such as benzenesulfonic acid and toluenesulfonic acid, di- and tricarboxylic acids and hydroxycarboxylic acids having 2 to 10 carbon atoms, such as oxalic acid, malonic acid, maleic acid, fumaric acid, lactic acid, tartaric acid, citric acid, glycolic acid, adipic acid and benzoic acid. Other utilizable acids are described, e.g., in Fortschritte der Arzneimittelforschung [Advances in drug research], Volume 10, pages 224 ff., Birkhäuser Verlag, Basel and Stuttgart, 1966.
The present invention moreover relates to compounds of formula (I) or (II) as defined herein, wherein at least one of the atoms has been replaced by its stable, non-radioactive isotope (e.g., hydrogen by deuterium, 12 C by 13 C, 14 N by 15 N, 16 O by 18 O) and preferably wherein at least one hydrogen atom has been replaced by a deuterium atom.
Of course, such compounds contain more of the respective isotope than this naturally occurs and thus is anyway present in the compounds (I) or (II).
Stable isotopes (e.g., deuterium, 13 C, 15 N, 18 O) are nonradioactive isotopes which contain one or more additional neutron than the normally abundant isotope of the respective atom. Deuterated compounds have been used in pharmaceutical research to investigate the in vivo metabolic fate of the compounds by evaluation of the mechanism of action and metabolic pathway of the non deuterated parent compound (Blake et al. J. Pharm. Sci. 64, 3, 367-391 (1975)). Such metabolic studies are important in the design of safe, effective therapeutic drugs, either because the in vivo active compound administered to the patient or because the metabolites produced from the parent compound prove to be toxic or carcinogenic (Foster et al., Advances in Drug Research Vol. 14, pp. 2-36, Academic press, London, 1985; Kato et al., J. Labelled Comp. Radiopharmaceut., 36(10):927-932 (1995); Kushner et al., Can. J. Physiol. Pharmacol., 77, 79-88 (1999).
Incorporation of a heavy atom particularly substitution of deuterium for hydrogen, can give rise to an isotope effect that could alter the pharmacokinetics of the drug. This effect is usually insignificant if the label is placed at a metabolically inert position of the molecule.
Stable isotope labeling of a drug can alter its physico-chemical properties such as pKa and lipid solubility. These changes may influence the fate of the drug at different steps along its passage through the body. Absorption, distribution, metabolism or excretion can be changed. Absorption and distribution are processes that depend primarily on the molecular size and the lipophilicity of the substance. These effects and alterations can affect the pharmacodynamic response of the drug molecule if the isotopic substitution affects a region involved in a ligand-receptor interaction.
Drug metabolism can give rise to large isotopic effect if the breaking of a chemical bond to a deuterium atom is the rate limiting step in the process. While some of the physical properties of a stable isotope-labeled molecule are different from those of the unlabeled one, the chemical and biological properties are the same, with one important exception: because of the increased mass of the heavy isotope, any bond involving the heavy isotope and another atom will be stronger than the same bond between the light isotope and that atom. In any reaction in which the breaking of this bond is the rate limiting step, the reaction will proceed slower for the molecule with the heavy isotope due to “kinetic isotope effect”. A reaction involving breaking a C—D bond can be up to 700 percent slower than a similar reaction involving breaking a C—H bond. If the C—D bond is not involved in any of the steps leading to the metabolite, there may not be any effect to alter the behavior of the drug. If a deuterium is placed at a site involved in the metabolism of a drug, an isotope effect will be observed only if breaking of the C—D bond is the rate limiting step. There is evidence to suggest that whenever cleavage of an aliphatic C—H bond occurs, usually by oxidation catalyzed by a mixed-function oxidase, replacement of the hydrogen by deuterium will lead to observable isotope effect. It is also important to understand that the incorporation of deuterium at the site of metabolism slows its rate to the point where another metabolite produced by attack at a carbon atom not substituted by deuterium becomes the major pathway a process called “metabolic switching”.
Deuterium tracers, such as deuterium-labeled drugs and doses, in some cases repeatedly, of thousands of milligrams of deuterated water, are also used in healthy humans of all ages, including neonates and pregnant women, without reported incident (e.g. Pons G and Rey E, Pediatrics 1999 104: 633; Coward W A et al., Lancet 1979 7: 13; Schwarcz H P, Control. Clin. Trials 1984 5(4 Suppl): 573; Rodewald L E et al., J. Pediatr. 1989 114: 885; Butte N F et al. Br. J. Nutr. 1991 65: 3; MacLennan A H et al. Am. J. Obstet. Gynecol. 1981 139: 948). Thus, it is clear that any deuterium released, for instance, during the metabolism of compounds of this invention poses no health risk.
The weight percentage of hydrogen in a mammal (approximately 9%) and natural abundance of deuterium (approximately 0.015%) indicates that a 70 kg human normally contains nearly a gram of deuterium. Furthermore, replacement of up to about 15% of normal hydrogen with deuterium has been effected and maintained for a period of days to weeks in mammals, including rodents and dogs, with minimal observed adverse effects (Czajka D M and Finkel A J, Ann. N.Y. Acad. Sci. 1960 84: 770; Thomson J F, Ann. New York Acad. Sci. 1960 84: 736; Czakja D M et al., Am. J. Physiol. 1961 201: 357). Higher deuterium concentrations, usually in excess of 20%, can be toxic in animals. However, acute replacement of as high as 15%-23% of the hydrogen in humans' fluids with deuterium was found not to cause toxicity (Blagojevic N et al. in “Dosimetry & Treatment Planning for Neutron Capture Therapy”, Zamenhof R, Solares G and Harling O Eds. 1994. Advanced Medical Publishing, Madison Wis. pp. 125-134; Diabetes Metab. 23: 251 (1997)).
Increasing the amount of deuterium present in a compound above its natural abundance is called enrichment or deuterium-enrichment. Examples of the amount of enrichment include from about 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 16, 21, 25, 29, 33, 37, 42, 46, 50, 54, 58, 63, 67, 71, 75, 79, 84, 88, 92, 96, to about 100 mol %.
The hydrogens present on a particular organic compound have different capacities for exchange with deuterium. Certain hydrogen atoms are easily exchangeable under physiological conditions and, if replaced by deuterium atoms, it is expected that they will readily exchange for protons after administration to a patient. Certain hydrogen atoms may be exchanged for deuterium atoms by the action of a deuteric acid such as D 2 SO 4 /D 2 O. Alternatively, deuterium atoms may be incorporated in various combinations during the synthesis of compounds of the invention. Certain hydrogen atoms are not easily exchangeable for deuterium atoms. However, deuterium atoms at the remaining positions may be incorporated by the use of deuterated starting materials or intermediates during the construction of compounds of the invention.
Deuterated and deuterium-enriched compounds of the invention can be prepared by using known methods described in the literature. Such methods can be carried out utilizing corresponding deuterated and optionally, other isotope-containing reagents and/or intermediates to synthesize the compounds delineated herein, or invoking standard synthetic protocols known in the art for introducing isotopic atoms to a chemical structure. Relevant procedures and intermediates are disclosed, for instance in Lizondo, J et al., Drugs Fut, 21(11), 1116 (1996); Brickner, S J et al., J Med Chem, 39(3), 673 (1996); Mallesham, B et al., Org Lett, 5(7), 963 (2003); PCT publications WO1997010223, WO2005099353, WO1995007271, WO2006008754; U.S. Pat. Nos. 7,538,189; 7,534,814; 7,531,685; 7,528,131; 7,521,421; 7,514,068; 7,511,013; and US Patent Application Publication Nos. 20090137457; 20090131485; 20090131363; 20090118238; 20090111840; 20090105338; 20090105307; 20090105147; 20090093422; 20090088416; 20090082471, the methods are hereby incorporated by reference.
The organic moieties mentioned in the above definitions of the variables are—like the term halogen—collective terms for individual listings of the individual group members. The prefix C n -C m indicates in each case the possible number of carbon atoms in the group.
Unless indicated otherwise, the term “substituted” means that a radical is substituted with 1, 2 or 3, especially 1, substituent which are in particular selected from the group consisting of halogen, C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 3 -C 12 -heterocyclyl-alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, C 1 -C 4 -alkenyl, OH, SH, CN, CF 3 , O—CF 3 , COON, O—CH 2 —COOH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, C 3 -C 7 -cycloalkyl, COO—C 1 -C 6 -alkyl, CONH 2 , CONN—C 1 -C 6 -alkyl, SO 2 NH—C 1 -C 6 -alkyl, CON—(C 1 -C 6 -alkyl) 2 , SO 2 N—(C 1 -C 6 -alkyl) 2 , NH 2 , NH—C 1 -C 6 -alkyl, N—(C 1 -C 6 -alkyl) 2 , NH—(C 1 -C 4 -alkyl-C 6 -C 12 -aryl), NH—CO—C 1 -C 6 -alkyl, NH—SO 2 —C 1 -C 6 -alkyl, SO 2 —C 1 -C 6 -alkyl, C 6 -C 12 -aryl, O—C 6 -C 12 -aryl, O—CH 2 —C 6 -C 12 -aryl, CONH—C 6 -C 12 -aryl, SO 2 NH—C 6 -C 12 -aryl, CONH—C 3 -C 12 -heterocyclyl, SO 2 NH—C 3 -C 12 -heterocyclyl, SO 2 —C 6 -C 12 -aryl, NH—SO 2 —C 6 -C 12 -aryl, NH—CO—C 6 -C 12 -aryl, NH—SO 2 —C 3 -C 12 -heterocyclyl, NH—CO—C 3 -C 12 -heterocyclyl and C 3 -C 12 -heterocyclyl, wherein aryl and heterocyclyl in turn may be unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy.
The term halogen denotes in each case fluorine, bromine, chlorine or iodine, in particular fluorine or chlorine.
C 1 -C 4 -Alkyl is a straight-chain or branched alkyl group having from 1 to 4 carbon atoms. Examples of an alkyl group are methyl, C 2 -C 4 -alkyl such as ethyl, n-propyl, iso-propyl, n-butyl, 2-butyl, iso-butyl or tert-butyl. C 1 -C 2 -Alkyl is methyl or ethyl, C 1 -C 3 -alkyl is additionally n-propyl or isopropyl.
C 1 -C 6 -Alkyl is a straight-chain or branched alkyl group having from 1 to 6 carbon atoms. Examples include methyl, C 2 -C 4 -alkyl as mentioned herein and also pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.
Halogenated C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms, such as in halogenomethyl, dihalogenomethyl, trihalogenomethyl, (R)-1-halogenoethyl, (S)-1-halogenoethyl, 2-halogenoethyl, 1,1-dihalogenoethyl, 2,2-dihalogenoethyl, 2,2,2-trihalogenoethyl, (R)-1-halogenopropyl, (S)-1-halogenopropyl, 2-halogenopropyl, 3-halogenopropyl, 1,1-dihalogenopropyl, 2,2-dihalogenopropyl, 3,3-dihalogenopropyl, 3,3,3-trihalogenopropyl, (R)-2-halogeno-1-methylethyl, (S)-2-halogeno-1-methylethyl, (R)-2,2-dihalogeno-1-methylethyl, (S)-2,2-dihalogeno-1-methylethyl, (R)-1,2-dihalogeno-1-methylethyl, (S)-1,2-dihalogeno-1-methylethyl, (R)-2,2,2-trihalogeno-1-methylethyl, (S)-2,2,2-trihalogeno-1-methylethyl, 2-halogeno-1-(halogenomethyl)ethyl, 1-(dihalogenomethyl)-2,2-dihalogenoethyl, (R)-1-halogenobutyl, (S)-1-halogenobutyl, 2-halogenobutyl, 3-halogenobutyl, 4-halogenobutyl, 1,1-dihalogenobutyl, 2,2-dihalogenobutyl, 3,3-dihalogenobutyl, 4,4-dihalogenobutyl, 4,4,4-trihalogenobutyl, etc. Particular examples include the fluorinated C 1 -C 4 alkyl groups as defined, such as trifluoromethyl.
C 6 -C 12 -Aryl-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by C 6 -C 12 -aryl, such as in benzyl.
Hydroxy-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, wherein one or two hydrogen atoms are replaced by one or two hydroxyl groups, such as in hydroxymethyl, (R)-1-hydroxyethyl, (S)-1-hydroxyethyl, 2-hydroxyethyl, (R)-1-hydroxypropyl, (S)-1-hydroxypropyl, 2-hydroxypropyl, 3-hydroxypropyl, (R)-2-hydroxy-1-methylethyl, (S)-2-hydroxy-1-methylethyl, 2-hydroxy-1-(hydroxymethyl)ethyl, (R)-1-hydroxybutyl, (S)-1-hydroxybutyl, 2-hydroxybutyl, 3-hydroxybutyl, 4-hydroxybutyl.
C 1 -C 6 -Alkoxy-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, wherein one or two hydrogen atoms are replaced by one or two alkoxy groups having 1 to 6, preferably 1 to 4, in particular 1 or 2 carbon atoms, such as in methoxymethyl, (R)-1-methoxyethyl, (S)-1-methoxyethyl, 2-methoxyethyl, (R)-1-methoxypropyl, (S)-1-methoxypropyl, 2-methoxypropyl, 3-methoxypropyl, (R)-2-methoxy-1-methylethyl, (S)-2-methoxy-1-methylethyl, 2-methoxy-1-(methoxymethyl)ethyl, (R)-1-methoxybutyl, (S)-1-methoxybutyl, 2-methoxybutyl, 3-methoxybutyl, 4-methoxybutyl, ethoxymethyl, (R)-1-ethoxyethyl, (S)-1-ethoxyethyl, 2-ethoxyethyl, (R)-1-ethoxypropyl, (S)-1-ethoxypropyl, 2-ethoxypropyl, 3-ethoxypropyl, (R)-2-ethoxy-1-methylethyl, (S)-2-ethoxy-1-methylethyl, 2-ethoxy-1-(ethoxymethyl)ethyl, (R)-1-ethoxybutyl, (S)-1-ethoxybutyl, 2-ethoxybutyl, 3-ethoxybutyl, 4-ethoxybutyl.
Amino-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by an amino group, such as in aminomethyl, 2-aminoethyl.
C 1 -C 6 -Alkylamino-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by a C 1 -C 6 -alkylamino group, in particular by a C 1 -C 4 -alkylamino group, such as in methylaminomethyl, ethylaminomethyl, n-propylaminomethyl, iso-propylaminomethyl, n-butylaminomethyl, 2-butylaminomethyl, iso-butylaminomethyl or tert-butylaminomethyl.
Di-C 1 -C 6 -Alkylamino-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by a di-C 1 -C 6 -Alkylamino group, in particular by a di-C 1 -C 4 -alkylamino group, such as in dimethylaminomethyl.
C 1 -C 6 -Alkylcarbonylamino-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by a C 1 -C 6 -alkylcarbonylamino group, in particular by a C 1 -C 4 -alkylcarbonylamino group, such as in methylcarbonylaminomethyl, ethylcarbonylaminomethyl, n-propylcarbonylaminomethyl, iso-propylcarbonylaminomethyl, n-butylcarbonylaminomethyl, 2-butylcarbonylaminomethyl, iso-butylcarbonylaminomethyl or tertbutylcarbonylaminomethyl.
C 1 -C 6 -Alkylaminocarbonylamino-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by a C 1 -C 6 -alkylaminocarbonylamino group, in particular by a C 1 -C 4 -alkylaminocarbonylamino group, such as in methylaminocarbonylaminomethyl, ethylaminocarbonylaminomethyl, n-propylaminocarbonylaminomethyl, iso-propylaminocarbonylaminomethyl, n-butylaminocarbonylaminomethyl, 2-butylaminocarbonylaminomethyl, isobutylaminocarbonylaminomethyl or tert-butylaminocarbonylaminomethyl.
Di-C 1 -C 6 -alkylaminocarbonylamino-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by a di-C 1 -C 6 -alkylaminocarbonylamino group, in particular by a di-C 1 -C 4 -alkylaminocarbonylamino group, such as in dimethylaminocarbonylaminomethyl, dimethylaminocarbonylaminoethyl, dimethylaminocarbonylaminon-propyl.
C 1 -C 6 -Alkylsulfonylamino-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by a C 1 -C 6 -alkylsulfonylamino group, in particular by a C 1 -C 4 -alkylsulfonylamino group, such as in methylsulfonylaminomethyl, ethylsulfonylaminomethyl, n-propylsulfonylaminomethyl, isopropylsulfonylaminomethyl, n-butylsulfonylaminomethyl, 2-butylsulfonylaminomethyl, isobutylsulfonylaminomethyl or tert-butylsulfonylaminomethyl.
(C 6 -C 12 -Aryl-C 1 -C 6 -alkyl)amino-C 1 -C 4 alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by a (C 6 -C 12 -aryl-C 1 -C 6 -alkyl)amino group, in particular a (C 6 -C 12 -aryl-C 1 -C 2 -alkyl)amino group, such as in benzylaminomethyl.
C 3 -C 12 -Heterocyclyl-C 1 -C 4 -alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably 1 or 2 carbon atoms, in particular 1 or two carbon atoms, wherein one hydrogen atom is replaced by C 3 -C 12 -heterocyclyl, such as in N-pyrrolidinylmethyl, N-piperidinylmethyl, N-morpholinylmethyl.
C 3 -C 12 -Cycloalkyl is a cycloaliphatic radical having from 3 to 12 carbon atoms. In particular, 3 to 6 carbon atoms form the cyclic structure, such as cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The cyclic structure may be unsubstituted or may carry 1, 2, 3 or 4 C 1 -C 4 alkyl radicals, preferably one or more methyl radicals.
Carbonyl is >C═O.
C 1 -C 6 -Alkylcarbonyl is a radical of the formula R—C(O)—, wherein R is an alkyl radical having from 1 to 6, preferably from 1 to 4, in particular 1 or 2 carbon atoms as defined herein. Examples include acetyl, propionyl, n-butyryl, 2-methylpropionyl, pivaloyl.
Halogenated C 1 -C 6 -alkylcarbonyl is C 1 -C 6 -alkylcarbonyl as defined herein, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms. Examples include fluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl. Further examples are 1,1,1-trifluoroeth-2-ylcarbonyl, 1,1,1-trifluoroprop-3-ylcarbonyl.
C 6 -C 12 -Arylcarbonyl is a radical of the formula R—C(O)—, wherein R is an aryl radical having from 6 to 12 carbon atoms as defined herein. Examples include benzoyl.
C 1 -C 6 -Alkoxycarbonyl is a radical of the formula R—O—C(O)—, wherein R is an alkyl radical having from 1 to 6, preferably from 1 to 4, in particular 1 or 2 carbon atoms as defined herein. Examples include methoxycarbonyl and tert-butyloxycarbonyl.
Halogenated C 1 -C 6 -alkoxycarbonyl is a C 1 -C 6 -alkoxycarbonyl as defined herein, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms.
C 6 -C 12 -Aryloxycarbonyl is a radical of the formula R—O—C(O)—, wherein R is an aryl radical having from 6 to 12 carbon atoms as defined herein. Examples include phenoxycarbonyl.
Cyano is —C≡N.
Aminocarbonyl is NH 2 C(O)—.
C 1 -C 6 -Alkylaminocarbonyl is a radical of the formula R—NH—C(O)—, wherein R is an alkyl radical having from 1 to 6, preferably from 1 to 4, in particular 1 or 2 carbon atoms as defined herein. Examples include methylaminocarbonyl.
(Halogenated C 1 -C 4 -alkyl)aminocarbonyl is a C 1 -C 4 -alkylaminocarbonyl as defined herein, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different hydrogen atoms.
C 6 -C 12 -Arylaminocarbonyl is a radical of the formula R—NH—C(O)—, wherein R is an aryl radical having from 6 to 12 carbon atoms as defined herein. Examples include phenylaminocarbonyl.
C 2 -C 6 -Alkenyl is a singly unsaturated hydrocarbon radical having 2, 3, 4, 5 or 6 carbon atoms, e.g. vinyl, allyl (2-propen-1-yl), 1-propen-1-yl, 2-propen-2-yl, methallyl(2-methylprop-2-en-1-yl) and the like. C 3 -C 5 -Alkenyl is, in particular, allyl, 1-methylprop-2-en-1-yl, 2-buten-1-yl, 3-buten-1-yl, methallyl, 2-penten-1-yl, 3-penten-1-yl, 4-penten-1-yl, 1-methylbut-2-en-1-yl or 2-ethylprop-2-en-1-yl.
C 2 -C 6 -Alkynyl is a singly unsaturated hydrocarbon radical having 2, 3, 4, 5 or 6 carbon atoms, e.g. ethynyl, 2-propyn-1-yl, 1-propyn-1-yl, 2-propyn-2-yl and the like. C 3 -C 5 -Alkynyl is, in particular, 2-propyn-1-yl, 2-butyn-1-yl, 3-butyn-1-yl, 2-pentyn-1-yl, 3-pentyn-1-yl, 4-pentyn-1-yl.
C 1 -C 4 -Alkylene is straight-chain or branched alkylene group having from 1 to 4 carbon atoms. Examples include methylene and ethylene. A further example is propylene.
C 2 -C 4 -Alkenylene is straight-chain or branched alkenylene group having from 2 to 4 carbon atoms.
C 2 -C 4 -Alkynylene is straight-chain or branched alkynylene group having from 2 to 4 carbon atoms. Examples include propynylene.
C 6 -C 12 -Aryl is a 6- to 12-membered, in particular 6- to 10-membered, aromatic cyclic radical. Examples include phenyl and naphthyl.
C 3 -C 12 -Arylene is an aryl diradical. Examples include phen-1,4-ylene and phen-1,3-ylene.
Hydroxy is —OH.
C 1 -C 6 -Alkoxy is a radical of the formula R—O—, wherein R is a straight-chain or branched alkyl group having from 1 to 6, in particular 1 to 4 carbon atoms. Examples include methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, 2-butoxy, iso-butoxy (2-methylpropoxy), tert.-butoxy pentyloxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexyloxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 1-methylpentyloxy, 2-methylpentyloxy, 3-methylpentyloxy, 4-methylpentyloxy, 1,1-dimethylbutyloxy, 1,2-dimethylbutyloxy, 1,3-dimethylbutyloxy, 2,2-dimethylbutyloxy, 2,3-dimethylbutyloxy, 3,3-dimethylbutyloxy, 1-ethylbutyloxy, 2-ethylbutyloxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2-methylpropoxy.
Halogenated C 1 -C 6 -alkoxy is a straight-chain or branched alkoxy group having from 1 to 6, preferably from 1 to 4, in particular 1 or 2 carbon atoms, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms, such as in halogenomethoxy, dihalogenomethoxy, trihalogenomethoxy, (R)-1-halogenoethoxy, (S)-1-halogenoethoxy, 2-halogenoethoxy, 1,1-dihalogenoethoxy, 2,2-dihalogenoethoxy, 2,2,2-trihalogenoethoxy, (R)-1-halogenopropoxy, (S)-1-halogenopropoxy, 2-halogenopropoxy, 3-halogenopropoxy, 1,1-dihalogenopropoxy, 2,2-dihalogenopropoxy, 3,3-dihalogenopropoxy, 3,3,3-trihalogenopropoxy, (R)-2-halogeno-1-methylethoxy, (S)-2-halogeno-1-methylethoxy, (R)-2,2-dihalogeno-1-methylethoxy, (S)-2,2-dihalogeno-1-methylethoxy, (R)-1,2-dihalogeno-1-methylethoxy, (S)-1,2-dihalogeno-1-methylethoxy, (R)-2,2,2-trihalogeno-1-methylethoxy, (S)-2,2,2-trihalogeno-1-methylethoxy, 2-halogeno-1-(halogenomethyl)ethoxy, 1-(dihalogenomethyl)-2,2-dihalogenoethoxy, (R)-1-halogenobutoxy, (S)-1-halogenobutoxy, 2-halogenobutoxy, 3-halogenobutoxy, 4-halogenobutoxy, 1,1-dihalogenobutoxy, 2,2-dihalogenobutoxy, 3,3-dihalogenobutoxy, 4,4-dihalogenobutoxy, 4,4,4-trihalogenobutoxy, etc. Particular examples include the fluorinated C 1 -C 4 alkoxy groups as defined, such as trifluoromethoxy.
C 1 -C 6 -Hydroxyalkoxy is an alkoxy radical having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein, wherein one or two hydrogen atoms are replaced by hydroxy. Examples include 2-hydroxyethoxy, 3-hydroxypropoxy, 2-hydroxypropoxy, 1-methyl-2-hydroxyethoxy and the like.
C 1 -C 6 -Alkoxy-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4 carbon atoms, preferably 1 or 2 carbon atoms as defined herein, wherein one or two hydrogen atoms are replaced by one or two alkoxy radicals having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include methoxymethoxy, 2-methoxyethoxy, 1-methoxyethoxy, 3-methoxypropoxy, 2-methoxypropoxy, 1-methyl-1-methoxyethoxy, ethoxymethoxy, 2-ethoxyethoxy, 1-ethoxyethoxy, 3-ethoxypropoxy, 2-ethoxypropoxy, 1-methyl-1-ethoxyethoxy and the like.
Amino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by an amino group. Examples include 2-aminoethoxy.
C 1 -C 6 -Alkylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by an alkylamino group having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include methylaminomethoxy, ethylaminomethoxy, n-propylaminomethoxy, isopropylaminomethoxy, n-butylaminomethoxy, 2-butylaminomethoxy, isobutylaminomethoxy, tert-butylaminomethoxy, 2-(methylamino)ethoxy, 2-(ethylamino)ethoxy, 2-(n-propylamino)ethoxy, 2-(iso-propylamino)ethoxy, 2-(n-butylamino)ethoxy, 2-(2-butylamino)ethoxy, 2-(iso-butylamino)ethoxy, 2-(tert-butylamino)ethoxy.
Di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by a di-alkylamino group having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include dimethylaminomethoxy, diethylaminomethoxy, N-methyl-N-ethylamino)ethoxy, 2-(dimethylamino)ethoxy, 2-(diethylamino)ethoxy, 2-(N-methyl-N-ethylamino)ethoxy.
C 1 -C 6 -Alkylcarbonylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by an alkylcarbonylamino group wherein the alkyl group has from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include methylcarbonylaminomethoxy, ethylcarbonylaminomethoxy, n-propylcarbonylaminomethoxy, isopropylcarbonylaminomethoxy, n-butylcarbonylaminomethoxy, 2-butylcarbonylaminomethoxy, iso-butylcarbonylaminomethoxy, tert-butylcarbonylaminomethoxy, 2-(methylcarbonylamino)ethoxy, 2-(ethylcarbonylamino)ethoxy, 2-(n-propylcarbonylamino)ethoxy, 2-(iso-propylcarbonylamino)ethoxy, 2-(n-butylcarbonylamino)ethoxy, 2-(2-butylcarbonylamino)ethoxy, 2-(iso-butylcarbonylamino)ethoxy, 2-(tert-butylcarbonylamino)ethoxy.
C 6 -C 12 -Arylcarbonylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by a C 6 -C 12 -arylcarbonylamino group as defined herein. Examples include 2-(benzoylamino)ethoxy.
C 1 -C 6 -Alkoxycarbonylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by an alkoxycarbonylamino group wherein the alkoxy group has from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include methoxycarbonylaminomethoxy, ethoxycarbonylaminomethoxy, n-propoxycarbonylaminomethoxy, isopropoxycarbonylaminomethoxy, n-butoxycarbonylaminomethoxy, 2-butoxycarbonylaminomethoxy, iso-butoxycarbonylaminomethoxy, tert-butoxycarbonylaminomethoxy, 2-(methoxycarbonylamino)ethoxy, 2-(ethoxycarbonylamino)ethoxy, 2-(n-propoxycarbonylamino)ethoxy, 2-(iso-propoxycarbonylamino)ethoxy, 2-(n-butoxycarbonylamino)ethoxy, 2-(2-butoxycarbonylamino)ethoxy, 2-(iso-butoxycarbonylamino)ethoxy, 2-(tert-butoxycarbonylamino)ethoxy.
C 2 -C 6 -Alkenyloxy is a radical of the formula R—O—, wherein R is a straight-chain or branched alkenyl group having from 2 to 6, in particular 2 to 4 carbon atoms. Examples include vinyloxy, allyloxy (2-propen-1-yloxy), 1-propen-1-yloxy, 2-propen-2-yloxy, methallyloxy (2-methylprop-2-en-1-yloxy) and the like. C 3 -C 5 -Alkenyloxy is, in particular, allyloxy, 1-methylprop-2-en-1-yloxy, 2-buten-1-yloxy, 3-buten-1-yloxy, methallyloxy, 2-penten-1-yloxy, 3-penten-1-yloxy, 4-penten-1-yloxy, 1-methylbut-2-en-1-yloxy or 2-ethylprop-2-en-1-yloxy.
C 6 -C 12 -Aryl-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by a C 6 -C 12 -aryl group as defined herein. Examples include benzyloxy.
C 1 -C 6 -Alkylsulfonylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by an alkylsulfonylamino group having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include 2-(methylsulfonylamino)ethoxy, 2-(ethylsulfonylamino)ethoxy, 2-[(2-methylpropyl)sulfonylamino]ethoxy.
(Halogenated C 1 -C 6 -alkyl)sulfonylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by an alkylsulfonylamino group having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein, wherein the alkyl group is halogenated. Examples include 2-(trifluoromethylsulfonylamino)ethoxy.
C 6 -C 12 -Arylsulfonylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by a C 6 -C 12 -arylsulfonylamino group as defined herein. Examples include 2-(phenylsulfonylamino)ethoxy, 2-(naphthylsulfonylamino)ethoxy.
(C 6 -C 12 -Aryl-C 1 -C 6 -alkyl)sulfonylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by a (C 6 -C 12 -aryl-C 1 -C 6 -alkyl)sulfonylamino group, preferably by a (C 6 -C 12 -aryl-C 1 -C 2 -alkyl)sulfonylamino group. Examples include 2-(benzylsulfonylamino)ethoxy.
C 3 -C 12 -Heterocyclylsulfonylamino-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by a C 3 -C 12 -heterocyclylsulfonylamino group as defined herein. Examples include 2-(pyridin-3-yl-sulfonylamino)ethoxy.
C 3 -C 12 -Heterocyclyl-C 1 -C 4 -alkoxy is an alkoxy radical having from 1 to 4, preferably 1 or 2 carbon atoms as defined herein, wherein one hydrogen atom is replaced by a C 3 -C 12 -heterocyclyl group as defined herein. Examples include 2-(N-pyrrolidinyl)ethoxy, 2-(N-morpholinyl)ethoxy and 2-(N-imidazolyl)ethoxy.
C 1 -C 2 -Alkylenedioxo is a radical of the formula —O—R—O—, wherein R is a straight-chain or branched alkylene group having from 1 or 2 carbon atoms as defined herein. Examples include methylenedioxo.
C 6 -C 12 -Aryloxy is a radical of the formula R—O—, wherein R is an aryl group having from 6 to 12, in particular 6 carbon atoms as defined herein. Examples include phenoxy.
C 3 -C 12 -Heterocyclyloxy is a radical of the formula R—O—, wherein R is a C 3 -C 12 -heterocyclyl group having from 3 to 12, in particular from 3 to 7 carbon atoms as defined herein. Examples include pyridin-2-yloxy.
C 1 -C 6 -Alkylthio is a radical of the formula R—S—, wherein R is an alkyl radical having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include methylthio, ethylthio, propylthio, butylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2-dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2-trimethylpropylthio, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.
Halogenated C 1 -C 6 -alkylthio is a radical of the formula R—S—, wherein R is a halogenated alkyl radical having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include halogenomethylthio, dihalogenomethylthio, trihalogenomethylthio, (R)-1-halogenoethylthio, (S)-1-halogenoethylthio, 2-halogenoethylthio, 1,1-dihalogenoethylthio, 2,2-dihalogenoethylthio, 2,2,2-trihalogenoethylthio, (R)-1-halogenopropylthio, (S)-1-halogenopropylthio, 2-halogenopropylthio, 3-halogenopropylthio, 1,1-dihalogenopropylthio, 2,2-dihalogenopropylthio, 3,3-dihalogenopropylthio, 3,3,3-trihalogenopropylthio, (R)-2-halogeno-1-methylethylthio, (S)-2-halogeno-1-methylethylthio, (R)-2,2-dihalogeno-1-methylethylthio, (S)-2,2-dihalogeno-1-methylethylthio, (R)-1,2-dihalogeno-1-methylethylthio, (S)-1,2-dihalogeno-1-methylethylthio, (R)-2,2,2-trihalogeno-1-methylethylthio, (S)-2,2,2-trihalogeno-1-methylethylthio, 2-halogeno-1-(halogenomethyl)ethylthio, 1-(dihalogenomethyl)-2,2-dihalogenoethylthio, (R)-1-halogenobutylthio, (S)-1-halogenobutylthio, 2-halogenobutylthio, 3-halogenobutylthio, 4-halogenobutylthio, 1,1-dihalogenobutylthio, 2,2-dihalogenobutylthio, 3,3-dihalogenobutylthio, 4,4-dihalogenobutylthio, 4,4,4-trihalogenobutylthio, etc. Particular examples include the fluorinated C 1 -C 4 alkylthio groups as defined, such as trifluoromethylthio.
C 1 -C 6 -Alkylsulfinyl is a radical of the formula R—S(O)—, wherein R is an alkyl radical having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include methylsulfinyl, ethylsulfinyl, propylsulfinyl, butylsulfinyl, pentylsulfinyl, 1-methylbutylsulfinyl, 2-methylbutylsulfinyl, 3-methylbutylsulfinyl, 2,2-dimethylpropylsulfinyl, 1-ethylpropylsulfinyl, hexylsulfinyl, 1,1-dimethylpropylsulfinyl, 1,2-dimethylpropylsulfinyl, 1-methylpentylsulfinyl, 2-methylpentylsulfinyl, 3-methylpentylsulfinyl, 4-methylpentylsulfinyl, 1,1-dimethylbutylsulfinyl, 1,2-dimethylbutylsulfinyl, 1,3-dimethylbutylsulfinyl, 2,2-dimethylbutylsulfinyl, 2,3-dimethylbutylsulfinyl, 3,3-dimethylbutylsulfinyl, 1-ethylbutylsulfinyl, 2-ethylbutylsulfinyl, 1,1,2-trimethylpropylsulfinyl, 1,2,2-trimethylpropylsulfinyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.
C 1 -C 6 -Alkylsulfonyl is a radical of the formula R—S(O) 2 —, wherein R is an alkyl radical having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include methylsulfonyl, ethylsulfonyl, propylsulfonyl, butylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.
(Halogenated C 1 -C 6 -alkyl)sulfonyl is a C 1 -C 6 -alkylsulfonyl as defined herein, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms.
C 6 -C 12 -Arylsulfonyl is a radical of the formula R—S(O) 2 —, wherein R is an aryl radical having from 6 to 12 carbon atoms as defined herein. Examples include phenylsulfonyl.
(C 6 -C 12 -Aryl-C 1 -C 4 -alkyl)sulfonyl is a radical of the formula R—S(O) 2 —, wherein R is a C 6 -C 12 -aryl-C 1 -C 4 -alkyl radical, in particular a C 6 -C 12 -aryl-C 1 -C 2 -alkyl radical as defined herein. Examples include benzylsulfonyl.
C 3 -C 12 -Heterocyclylsulfonyl is a radical of the formula R—S(O) 2 —, wherein R is C 3 -C 12 -heterocyclyl as defined herein.
Aminosulfonyl is NH 2 —S(O) 2 —.
C 1 -C 6 -Alkylaminosulfonyl is a radical of the formula R—NH—S(O) 2 — wherein R is an alkyl radical having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include methylaminosulfonyl, ethylaminosulfonyl, n-propylaminosulfonyl, isopropylaminosulfonyl, n-butylaminosulfonyl, 2-butylaminosulfonyl, iso-butylaminosulfonyl, tert-butylaminosulfonyl.
Di-C 1 -C 6 -alkylaminosulfonyl is a radical of the formula RR′N—S(O) 2 — wherein R and R′ are independently of each other an alkyl radical having from 1 to 6, preferably from 1 to 4 carbon atoms as defined herein. Examples include dimethylaminosulfonyl, diethylaminosulfonyl, N-methyl-N-ethylaminosulfonyl.
C 6 -C 12 -Arylaminosulfonyl is a radical of the formula R—NH—S(O) 2 — wherein R is an aryl radical having from 6 to 12, preferably 6 carbon atoms as defined herein.
Amino is NH 2 .
C 1 -C 6 -Alkylamino is a radical of the formula R—NH— wherein R is an alkyl radical having from 1 to 6, in particular from 1 to 4 carbon atoms as defined herein. Examples include methylamino, ethylamino, n-propylamino, iso-propylamino, n-butylamino, 2-butylamino, iso-butylamino, tert-butylamino.
(Halogenated C 1 -C 6 -alkyl)amino is a C 1 -C 6 -alkylamino as defined herein, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms.
Di-C 1 -C 6 -alkylamino is a radical of the formula RR′N— wherein R and R′ are independently of each other an alkyl radical having from 1 to 6, in particular from 1 to 4 carbon atoms as defined herein. Examples include dimethylamino, diethylamino, N-methyl-N-ethylamino.
Di-(halogenated C 1 -C 6 -alkyl)amino is a di-C 1 -C 6 -alkylamino as defined herein, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms.
C 1 -C 6 -Alkylcarbonylamino is a radical of the formula R—C(O)—NH—, wherein R is an alkyl radical having from 1 to 6, in particular from 1 to 4 carbon atoms as defined herein. Examples include acetamido (methylcarbonylamino), propionamido, n-butyramido, 2-methylpropionamido (isopropylcarbonylamino), 2,2-dimethylpropionamido and the like.
(Halogenated C 1 -C 6 -alkyl)carbonylamino is a C 1 -C 6 -alkylcarbonylamino as defined herein, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms.
C 6 -C 12 -Arylcarbonylamino is a radical of the formula R—C(O)—NH—, wherein R is an aryl radical having from 6 to 12 carbon atoms as defined herein. Examples include phenylcarbonylamino.
C 2 -C 6 -Alkenylamino is a radical of the formula R—NH—, wherein R is a straight-chain or branched alkenyl group having from 2 to 6, in particular 2 to 4 carbon atoms. Examples include vinylamino, allylamino (2-propen-1-ylamino), 1-propen-1-ylamino, 2-propen-2-ylamino, methallylamino (2-methylprop-2-en-1-ylamino) and the like. C 3 -C 5 -Alkenylamino is, in particular, allylamino, 1-methylprop-2-en-1-ylamino, 2-buten-1-ylamino, 3-buten-1-ylamino, methallylamino, 2-penten-1-ylamino, 3-penten-1-ylamino, 4-penten-1-ylamino, 1-methylbut-2-en-1-ylamino or 2-ethylprop-2-en-1-ylamino.
C 1 -C 6 -Alkylsulfonylamino is a radical of the formula R—S(O) 2 —NH—, wherein R is an alkyl radical having from 1 to 6, in particular from 1 to 4 carbon atoms as defined herein. Examples include methylsulfonylamino, ethylsulfonylamino, n-propylsulfonylamino, iso-propylsulfonylamino, n-butylsulfonylamino, 2-butylsulfonylamino, iso-butylsulfonylamino, tert-butylsulfonylamino.
(Halogenated C 1 -C 6 alkyl)sulfonylamino is a C 1 -C 6 -alkylsulfonylamino as defined herein, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by 1, 2, 3, 4 or a corresponding number of identical or different halogen atoms.
C 6 -C 12 -Arylsulfonylamino is a radical of the formula R—S(O) 2 —NH—, wherein R is an aryl radical having from 6 to 12 carbon atoms as defined herein. Examples include phenylsulfonylamino.
Nitro is —NO 2 .
C 3 -C 12 -Heterocyclyl is a 3- to 12-membered heterocyclic radical including a saturated heterocyclic radical, which generally has 3, 4, 5, 6, or 7 ring forming atoms (ring members), an unsaturated non-aromatic heterocyclic radical, which generally has 5, 6 or 7 ring forming atoms, and a heteroaromatic radical (hetaryl), which generally has 5, 6 or 7 ring forming atoms. The heterocyclic radicals may be bound via a carbon atom (C-bound) or a nitrogen atom (N-bound). Preferred heterocyclic radicals comprise 1 nitrogen atom as ring member atom and optionally 1, 2 or 3 further heteroatoms as ring members, which are selected, independently of each other from O, S and N. Likewise preferred heterocyclic radicals comprise 1 heteroatom as ring member, which is selected from O, S and N, and optionally 1, 2 or 3 further nitrogen atoms as ring members.
Examples of C 3 -C 12 -heterocyclyl include:
C- or N-bound 3-4-membered, saturated rings, such as
2-oxiranyl, 2-oxetanyl, 3-oxetanyl, 2-aziridinyl, 3-thiethanyl, 1-azetidinyl, 2-azetidinyl, 3-azetidinyl;
C-bound, 5-membered, saturated rings, such as
tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrothien-2-yl, tetrahydrothien-3-yl, tetrahydropyrrol-2-yl, tetrahydropyrrol-3-yl, tetrahydropyrazol-3-yl, tetrahydro-pyrazol-4-yl, tetrahydroisoxazol-3-yl, tetrahydroisoxazol-4-yl, tetrahydroisoxazol-5-yl, 1,2-oxathiolan-3-yl, 1,2-oxathiolan-4-yl, 1,2-oxathiolan-5-yl, tetrahydroisothiazol-3-yl, tetrahydroisothiazol-4-yl, tetrahydroisothiazol-5-yl, 1,2-dithiolan-3-yl, 1,2-dithiolan-4-yl, tetrahydroimidazol-2-yl, tetrahydroimidazol-4-yl, tetrahydrooxazol-2-yl, tetrahydrooxazol-4-yl, tetrahydrooxazol-5-yl, tetrahydrothiazol-2-yl, tetrahydrothiazol-4-yl, tetrahydrothiazol-5-yl, 1,3-dioxolan-2-yl, 1,3-dioxolan-4-yl, 1,3-oxathiolan-2-yl, 1,3-oxathiolan-4-yl, 1,3-oxathiolan-5-yl, 1,3-dithiolan-2-yl, 1,3-dithiolan-4-yl, 1,3,2-dioxathiolan-4-yl;
C-bound, 6-membered, saturated rings, such as
tetrahydropyran-2-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, tetrahydrothiopyran-2-yl, tetrahydrothiopyran-3-yl, tetrahydrothiopyran-4-yl, 1,3-dioxan-2-yl, 1,3-dioxan-4-yl, 1,3-dioxan-5-yl, 1,4-dioxan-2-yl, 1,3-dithian-2-yl, 1,3-dithian-4-yl, 1,3-dithian-5-yl, 1,4-dithian-2-yl, 1,3-oxathian-2-yl, 1,3-oxathian-4-yl, 1,3-oxathian-5-yl, 1,3-oxathian-6-yl, 1,4-oxathian-2-yl, 1,4-oxathian-3-yl, 1,2-dithian-3-yl, 1,2-dithian-4-yl, hexahydropyrimidin-2-yl, hexahydropyrimidin-4-yl, hexahydropyrimidin-5-yl, hexahydropyrazin-2-yl, hexahydropyridazin-3-yl, hexahydropyridazin-4-yl, tetrahydro-1,3-oxazin-2-yl, tetrahydro-1,3-oxazin-4-yl, tetrahydro-1,3-oxazin-5-yl, tetrahydro-1,3-oxazin-6-yl, tetrahydro-1,3-thiazin-2-yl, tetrahydro-1,3-thiazin-4-yl, tetrahydro-1,3-thiazin-5-yl, tetrahydro-1,3-thiazin-6-yl, tetrahydro-1,4-thiazin-2-yl, tetrahydro-1,4-thiazin-3-yl, tetrahydro-1,4-oxazin-2-yl, tetrahydro-1,4-oxazin-3-yl, tetrahydro-1,2-oxazin-3-yl, tetrahydro-1,2-oxazin-4-yl, tetrahydro-1,2-oxazin-5-yl, tetrahydro-1,2-oxazin-6-yl;
N-bound, 5-membered, saturated rings, such as
tetrahydropyrrol-1-yl (pyrrolidin-1-yl), tetrahydropyrazol-1-yl, tetrahydroisoxazol-2-yl, tetrahydroisothiazol-2-yl, tetrahydroimidazol-1-yl, tetrahydrooxazol-3-yl, tetrahydrothiazol-3-yl;
N-bound, 6-membered, saturated rings, such as
piperidin-1-yl, hexahydropyrimidin-1-yl, hexahydropyrazin-1-yl (piperazin-1-yl), hexahydropyridazin-1-yl, tetrahydro-1,3-oxazin-3-yl, tetrahydro-1,3-thiazin-3-yl, tetrahydro-1,4-thiazin-4-yl, tetrahydro-1,4-oxazin-4-yl(morpholin-1-yl), tetrahydro-1,2-oxazin-2-yl;
C-bound, 5-membered, partially unsaturated rings, such as
2,3-dihydrofuran-2-yl, 2,3-dihydrofuran-3-yl, 2,5-dihydrofuran-2-yl, 2,5-di-hydrofuran-3-yl, 4,5-dihydrofuran-2-yl, 4,5-dihydrofuran-3-yl, 2,3-dihydro-thien-2-yl, 2,3-dihydrothien-3-yl, 2,5-dihydrothien-2-yl, 2,5-dihydrothien-3-yl, 4,5-dihydrothien-2-yl, 4,5-dihydrothien-3-yl, 2,3-dihydro-1H-pyrrol-2-yl, 2,3-dihydro-1H-pyrrol-3-yl, 2,5-dihydro-1H-pyrrol-2-yl, 2,5-dihydro-1H-pyrrol-3-yl, 4,5-dihydro-1H-pyrrol-2-yl, 4,5-dihydro-1H-pyrrol-3-yl, 3,4-dihydro-2H-pyrrol-2-yl, 3,4-dihydro-2H-pyrrol-3-yl, 3,4-dihydro-5H-pyrrol-2-yl, 3,4-dihydro-5H-pyrrol-3-yl, 4,5-dihydro-1H-pyrazol-3-yl, 4,5-dihydro-1H-pyrazol-4-yl, 4,5-dihydro-1H-pyrazol-5-yl, 2,5-dihydro-1H-pyrazol-3-yl, 2,5-dihydro-1H-pyrazol-4-yl, 2,5-dihydro-1H-pyrazol-5-yl, 4,5-dihydroisoxazol-3-yl, 4,5-dihydroisoxazol-4-yl, 4,5-dihydroisoxazol-5-yl, 2,5-dihydroisoxazol-3-yl, 2,5-dihydroisoxazol-4-yl, 2,5-dihydroisoxazol-5-yl, 2,3-dihydroisoxazol-3-yl, 2,3-dihydroisoxazol-4-yl, 2,3-dihydroisoxazol-5-yl, 4,5-dihydroisothiazol-3-yl, 4,5-dihydroisothiazol-4-yl, 4,5-dihydroisothiazol-5-yl, 2,5-dihydroisothiazol-3-yl, 2,5-dihydroisothiazol-4-yl, 2,5-dihydroisothiazol-5-yl, 2,3-dihydroisothiazol-3-yl, 2,3-dihydroisothiazol-4-yl, 2,3-dihydroisothiazol-5-yl, 4,5-dihydro-1H-imidazol-2-yl, 4,5-dihydro-1H-imidazol-4-yl, 4,5-dihydro-1H-imidazol-5-yl, 2,5-dihydro-1H-imidazol-2-yl, 2,5-dihydro-1H-imidazol-4-yl, 2,5-dihydro-1H-imidazol-5-yl, 2,3-dihydro-1H-imidazol-2-yl, 2,3-dihydro-1H-imidazol-4-yl, 4,5-dihydro-oxazol-2-yl, 4,5-dihydrooxazol-4-yl, 4,5-dihydrooxazol-5-yl, 2,5-dihydrooxazol-2-yl, 2,5-dihydrooxazol-4-yl, 2,5-dihydrooxazol-5-yl, 2,3-dihydrooxazol-2-yl, 2,3-dihydrooxazol-4-yl, 2,3-dihydrooxazol-5-yl, 4,5-dihydrothiazol-2-yl, 4,5-dihydrothiazol-4-yl, 4,5-dihydrothiazol-5-yl, 2,5-dihydrothiazol-2-yl, 2,5-dihydrothiazol-4-yl, 2,5-dihydrothiazol-5-yl, 2,3-dihydrothiazol-2-yl, 2,3-dihydrothiazol-4-yl, 2,3-dihydrothiazol-5-yl, 1,3-dioxol-2-yl, 1,3-dioxol-4-yl, 1,3-dithiol-2-yl, 1,3-dithiol-4-yl, 1,3-oxathiol-2-yl, 1,3-oxathiol-4-yl, 1,3-oxathiol-5-yl;
C-bound, 6-membered, partially unsaturated rings, such as
2H-3,4-dihydropyran-6-yl, 2H-3,4-dihydropyran-5-yl, 2H-3,4-dihydropyran-4-yl, 2H-3,4-dihydropyran-3-yl, 2H-3,4-dihydropyran-2-yl, 2H-3,4-dihydrothiopyran-6-yl, 2H-3,4-dihydrothiopyran-5-yl, 2H-3,4-dihydrothiopyran-4-yl, 2H-3,4-dihydrothiopyran-3-yl, 2H-3,4-dihydrothiopyran-2-yl, 1,2,3,4-tetrahydropyridin-6-yl, 1,2,3,4-tetrahydropyridin-5-yl, 1,2,3,4-tetrahydropyridin-4-yl, 1,2,3,4-tetra-hydropyridin-3-yl, 1,2,3,4-tetrahydropyridin-2-yl, 2H-5,6-dihydropyran-2-yl, 2H-5,6-dihydropyran-3-yl, 2H-5,6-dihydropyran-4-yl, 2H-5,6-dihydropyran-5-yl, 2H-5,6-dihydropyran-6-yl, 2H-5,6-dihydrothiopyran-2-yl, 2H-5,6-dihydrothiopyran-3-yl, 2H-5,6-dihydrothiopyran-4-yl, 2H-5,6-dihydrothiopyran-5-yl, 2H-5,6-dihydrothiopyran-6-yl, 1,2,5,6-tetrahydropyridin-2-yl, 1,2,5,6-tetrahydropyridin-3-yl, 1,2,5,6-tetrahydropyridin-4-yl, 1,2,5,6-tetrahydropyridin-5-yl, 1,2,5,6-tetrahydropyridin-6-yl, 2,3,4,5-tetrahydropyridin-2-yl, 2,3,4,5-tetrahydropyridin-3-yl, 2,3,4,5-tetrahydropyridin-4-yl, 2,3,4,5-tetrahydropyridin-5-yl, 2,3,4,5-tetrahydropyridin-6-yl, 4H-pyran-2-yl, 4H-pyran-3-yl-, 4H-pyran-4-yl, 4H-thiopyran-2-yl, 4H-thiopyran-3-yl, 4H-thiopyran-4-yl, 1,4-dihydropyridin-2-yl, 1,4-dihydropyridin-3-yl, 1,4-dihydropyridin-4-yl, 2H-pyran-2-yl, 2H-pyran-3-yl, 2H-pyran-4-yl, 2H-pyran-5-yl, 2H-pyran-6-yl, 2H-thiopyran-2-yl, 2H-thiopyran-3-yl, 2H-thiopyran-4-yl, 2H-thiopyran-5-yl, 2H-thiopyran-6-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydro-pyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydro-pyridin-6-yl, 3,4-dihydropyridin-2-yl, 3,4-dihydropyridin-3-yl, 3,4-dihydro-pyridin-4-yl, 3,4-dihydropyridin-5-yl, 3,4-dihydropyridin-6-yl, 2,5-dihydropyridin-2-yl, 2,5-dihydropyridin-3-yl, 2,5-dihydropyridin-4-yl, 2,5-dihydropyridin-5-yl, 2,5-dihydropyridin-6-yl, 2,3-dihydropyridin-2-yl, 2,3-dihydropyridin-3-yl, 2,3-dihydropyridin-4-yl, 2,3-dihydropyridin-5-yl, 2,3-dihydropyridin-6-yl, 2H-5,6-dihydro-1,2-oxazin-3-yl, 2H-5,6-dihydro-1,2-oxazin-4-yl, 2H-5,6-dihydro-1,2-oxazin-5-yl, 2H-5,6-dihydro-1,2-oxazin-6-yl, 2H-5,6-dihydro-1,2-thiazin-3-yl, 2H-5,6-dihydro-1,2-thiazin-4-yl, 2H-5,6-dihydro-1,2-thiazin-5-yl, 2H-5,6-dihydro-1,2-thiazin-6-yl, 4H-5,6-dihydro-1,2-oxazin-3-yl, 4H-5,6-dihydro-1,2-oxazin-4-yl, 4H-5,6-dihydro-1,2-oxazin-5-yl, 4H-5,6-dihydro-1,2-oxazin-6-yl, 4H-5,6-dihydro-1,2-thiazin-3-yl, 4H-5,6-dihydro-1,2-thiazin-4-yl, 4H-5,6-dihydro-1,2-thiazin-5-yl, 4H-5,6-dihydro-1,2-thiazin-6-yl, 2H-3,6-dihydro-1,2-oxazin-3-yl, 2H-3,6-dihydro-1,2-oxazin-4-yl, 2H-3,6-dihydro-1,2-oxazin-5-yl, 2H-3,6-dihydro-1,2-oxazin-6-yl, 2H-3,6-dihydro-1,2-thiazin-3-yl, 2H-3,6-dihydro-1,2-thiazin-4-yl, 2H-3,6-dihydro-1,2-thiazin-5-yl, 2H-3,6-dihydro-1,2-thiazin-6-yl, 2H-3,4-dihydro-1,2-oxazin-3-yl, 2H-3,4-dihydro-1,2-oxazin-4-yl, 2H-3,4-dihydro-1,2-oxazin-5-yl, 2H-3,4-dihydro-1,2-oxazin-6-yl, 2H-3,4-dihydro-1,2-thiazin-3-yl, 2H-3,4-dihydro-1,2-thiazin-4-yl, 2H-3,4-dihydro-1,2-thiazin-5-yl, 2H-3,4-dihydro-1,2-thiazin-6-yl, 2,3,4,5-tetrahydropyridazin-3-yl, 2,3,4,5-tetrahydropyridazin-4-yl, 2,3,4,5-tetrahydropyridazin-5-yl, 2,3,4,5-tetrahydropyridazin-6-yl, 3,4,5,6-tetrahydropyridazin-3-yl, 3,4,5,6-tetrahydropyridazin-4-yl, 1,2,5,6-tetrahydropyridazin-3-yl, 1,2,5,6-tetrahydropyridazin-4-yl, 1,2,5,6-tetra-hydropyridazin-5-yl, 1,2,5,6-tetrahydropyridazin-6-yl, 1,2,3,6-tetrahydro-pyridazin-3-yl, 1,2,3,6-tetrahydropyridazin-4-yl, 4H-5,6-dihydro-1,3-oxazin-2-yl, 4H-5,6-dihydro-1,3-oxazin-4-yl, 4H-5,6-dihydro-1,3-oxazin-5-yl, 4H-5,6-dihydro-1,3-oxazin-6-yl, 4H-5,6-dihydro-1,3-thiazin-2-yl, 4H-5,6-dihydro-1,3-thiazin-4-yl, 4H-5,6-dihydro-1,3-thiazin-5-yl, 4H-5,6-dihydro-1,3-thiazin-6-yl, 3,4,5-6-tetrahydropyrimidin-2-yl, 3,4,5,6-tetrahydropyrimidin-4-yl, 3,4,5,6-tetrahydropyrimidin-5-yl, 3,4,5,6-tetrahydropyrimidin-6-yl, 1,2,3,4-tetrahydropyrazin-2-yl, 1,2,3,4-tetrahydropyrazin-5-yl, 1,2,3,4-tetrahydro-pyrimidin-2-yl, 1,2,3,4-tetrahydropyrimidin-4-yl, 1,2,3,4-tetrahydropyrimidin-5-yl, 1,2,3,4-tetrahydropyrimidin-6-yl, 2,3-dihydro-1,4-thiazin-2-yl, 2,3-dihydro-1,4-thiazin-3-yl, 2,3-dihydro-1,4-thiazin-5-yl, 2,3-dihydro-1,4-thiazin-6-yl, 2H-1,3-oxazin-2-yl, 2H-1,3-oxazin-4-yl, 2H-1,3-oxazin-5-yl, 2H-1,3-oxazin-6-yl, 2H-1,3-thiazin-2-yl, 2H-1,3-thiazin-4-yl, 2H-1,3-thiazin-5-yl, 2H-1,3-thiazin-6-yl, 4H-1,3-oxazin-2-yl, 4H-1,3-oxazin-4-yl, 4H-1,3-oxazin-5-yl, 4H-1,3-oxazin-6-yl, 4H-1,3-thiazin-2-yl, 4H-1,3-thiazin-4-yl, 4H-1,3-thiazin-5-yl, 4H-1,3-thiazin-6-yl, 6H-1,3-oxazin-2-yl, 6H-1,3-oxazin-4-yl, 6H-1,3-oxazin-5-yl, 6H-1,3-oxazin-6-yl, 6H-1,3-thiazin-2-yl, 6H-1,3-oxazin-4-yl, 6H-1,3-oxazin-5-yl, 6H-1,3-thiazin-6-yl, 2H-1,4-oxazin-2-yl, 2H-1,4-oxazin-3-yl, 2H-1,4-oxazin-5-yl, 2H-1,4-oxazin-6-yl, 2H-1,4-thiazin-2-yl, 2H-1,4-thiazin-3-yl, 2H-1,4-thiazin-5-yl, 2H-1,4-thiazin-6-yl, 4H-1,4-oxazin-2-yl, 4H-1,4-oxazin-3-yl, 4H-1,4-thiazin-2-yl, 4H-1,4-thiazin-3-yl, 1,4-dihydropyridazin-3-yl, 1,4-dihydropyridazin-4-yl, 1,4-dihydropyridazin-5-yl, 1,4-dihydropyridazin-6-yl, 1,4-dihydropyrazin-2-yl, 1,2-dihydropyrazin-2-yl, 1,2-dihydropyrazin-3-yl, 1,2-dihydropyrazin-5-yl, 1,2-dihydropyrazin-6-yl, 1,4-dihydropyrimidin-2-yl, 1,4-dihydropyrimidin-4-yl, 1,4-dihydropyrimidin-5-yl, 1,4-dihydropyrimidin-6-yl, 3,4-dihydropyrimidin-2-yl, 3,4-dihydropyrimidin-4-yl, 3,4-dihydropyrimidin-5-yl or 3,4-dihydropyrimidin-6-yl;
N-bound, 5-membered, partially unsaturated rings, such as
2,3-dihydro-1H-pyrrol-1-yl, 2,5-dihydro-1H-pyrrol-1-yl, 4,5-dihydro-1H-pyrazol-1-yl, 2,5-dihydro-1H-pyrazol-1-yl, 2,3-dihydro-1H-pyrazol-1-yl, 2,5-dihydroisoxazol-2-yl, 2,3-dihydroisoxazol-2-yl, 2,5-dihydroisothiazol-2-yl, 2,3-dihydroisoxazol-2-yl, 4,5-dihydro-1H-imidazol-1-yl, 2,5-dihydro-1H-imidazol-1-yl, 2,3-dihydro-1H-imidazol-1-yl, 2,3-dihydrooxazol-3-yl, 2,3-dihydrothiazol-3-yl;
N-bound, 6-membered, partially unsaturated rings, such as
1,2,3,4-tetrahydropyridin-1-yl, 1,2,5,6-tetrahydropyridin-1-yl, 1,4-dihydro-pyridin-1-yl, 1,2-dihydropyridin-1-yl, 2H-5,6-dihydro-1,2-oxazin-2-yl, 2H-5,6-dihydro-1,2-thiazin-2-yl, 2H-3,6-dihydro-1,2-oxazin-2-yl, 2H-3,6-dihydro-1,2-thiazin-2-yl, 2H-3,4-dihydro-1,2-oxazin-2-yl, 2H-3,4-dihydro-1,2-thiazin-2-yl, 2,3,4,5-tetrahydropyridazin-2-yl, 1,2,5,6-tetrahydropyridazin-1-yl, 1,2,5,6-tetrahydropyridazin-2-yl, 1,2,3,6-tetrahydropyridazin-1-yl, 3,4,5,6-tetrahydropyrimidin-3-yl, 1,2,3,4-tetrahydropyrazin-1-yl, 1,2,3,4-tetrahydropyrimidin-1-yl, 1,2,3,4-tetrahydropyrimidin-3-yl, 2,3-dihdro-1,4-thiazin-4-yl, 2H-1,2-oxazin-2-yl, 2H-1,2-thiazin-2-yl, 4H-1,4-oxazin-4-yl, 4H-1,4-thiazin-4-yl, 1,4-dihydropyridazin-1-yl, 1,4-dihydropyrazin-1-yl, 1,2-dihydropyrazin-1-yl, 1,4-dihydropyrimidin-1-yl or 3,4-dihydropyrimidin-3-yl;
C-bound, 5-membered, heteroaromatic rings, such as
2-furyl, 3-furyl, 2-thienyl, 3-thienyl, pyrrol-2-yl, pyrrol-3-yl, pyrazol-3-yl, pyrazol-4-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, imidazol-2-yl, imidazol-4-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, 1,2,3-oxadiazol-4-yl, 1,2,3-oxadiazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4,-oxadiazol-5-yl, 1,3,4-oxadiazol-2-yl, 1,2,3-thiadiazol-4-yl, 1,2,3-thiadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazolyl-2-yl, 1,2,3-triazol-4-yl, 1,2,4-triazol-3-yl, tetrazol-5-yl;
C-bound, 6-membered, heteroaromatic rings, such as
pyridin-2-yl, pyridin-3-yl, pyridin-4-yl (4-pyridyl), pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4-triazin-5-yl, 1,2,4-triazin-6-yl, 1,2,4,5-tetrazin-3-yl;
N-bound, 5-membered, heteroaromatic rings, such as
pyrrol-1-yl, pyrazol-1-yl, imidazol-1-yl, 1,2,3-triazol-1-yl, 1,2,4-triazol-1-yl, tetrazol-1-yl.
Heterocyclyl also includes bicyclic heterocycles, which comprise one of the described 5- or 6-membered heterocyclic rings and a further anellated, saturated or unsaturated or aromatic carbocycle, such as a benzene, cyclohexane, cyclohexene or cyclohexadiene ring, or a further anellated 5- or 6-membered heterocyclic ring, this heterocyclic ring being saturated or unsaturated or aromatic. These include quinolinyl, isoquinolinyl, indolyl, indolizinyl, isoindolyl, indazolyl, benzofuryl, benzthienyl, benzo[b]thiazolyl, benzoxazolyl, benzthiazolyl and benzimidazolyl. Examples of 5- or 6-membered heteroaromatic compounds comprising an anellated cycloalkenyl ring include dihydroindolyl, dihydroindolizinyl, dihydroisoindolyl, dihydrochinolinyl, dihydroisoquinolinyl, chromenyl and chromanyl.
C 3 -C 12 -Heteroarylene is a heteroaryl diradical. Examples include pyrid-2,5-ylene and pyrid-2,4-ylene.
With respect to the compounds' capability of inhibiting glycine transporter 1, the variables A, R, R 1 , W, A 1 , Q, Y, A 2 , X 1 , R 2 , R 3 , R 4 , X 2 , X 3 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , n preferably have the following meanings which, when taken alone or in combination, represent particular embodiments of the aminotetraline derivatives of the formula (I), (II) or any other formula disclosed herein.
In said formula (I) or (II), there may be one or more than one substituent R, R 2 and/or R 3 . More particularly, there may be up to 3 substituents R 2 , and up to 6 substituents R 3 . Preferably there is one substituent R and 1, 2 or 3 substituents R 2 . Formula (I) may thus be depicted as follows:









wherein a is 1, 2 or 3, b is 1, 2, 3, 4, 5 or 6 and c is 1. If there is more than one radical R 2 , these may be the same or different radicals. If there is more than one radical R 3 , these may be the same or different radicals.
A is a 5- or 6-membered ring which includes two carbon atoms from the cyclopentane, cyclohexane or cycloheptane moiety to which A is fused. A may be a homocyclic or heterocyclic ring. The ring may be saturated, unsaturated non-aromatic or aromatic. According to a particular embodiment, A is a benzene ring. As a heterocyclic ring, A may include 1, 2 or 3 heteroatoms as ring member atoms, which are selected, independently of each other from N, S and O. Preferred heterocyclic rings comprise 1 nitrogen atom as ring member atom and optionally 1 or 2 further heteroatoms as ring members, which are selected, independently of each other from O, S and N. Likewise preferred heterocyclic radicals comprise 1 heteroatom as ring member atom, which is selected from O, S and N, and optionally 1 or 2 further nitrogen atoms as ring member atoms. According to a particular embodiment, A is a heterocyclic ring selected from the group consisting of the following 5- or 6-membered heterocyclic rings:









In said formulae, hydrogen atoms are not depicted. This is meant to illustrate that the free valency of a carbon or nitrogen atom may be either bound to a hydrogen atom, to R or to R 2 . Accordingly, R and R 2 may be C- or N-bound at any position of ring A.
The skilled person will appreciate that some of the rings depicted above may be represented with a different structure, e.g. with hydrogen atoms having other positions than those shown above, for instance as given in the following structures:









Preferably, A is a heterocyclic ring selected from the group consisting of the following 5- or 6-membered heterocyclic rings:









According to a further particular embodiment, A is a heterocyclic ring selected from the group consisting of the following 5- or 6-membered heterocyclic rings:









According to a perferred embodiment, A is a heterocyclic ring selected from the group consisting of the following 5- or 6-membered heterocyclic rings:









If ring A is a 5-membered heterocyclic ring it is preferred that R is bound to G 1 or G 2 , in particular G 2 :









In said formula, G 1 , G 2 and G 3 independently are —CH═, —CH 2 —, —N═, —NH—, S or O, the dotted line represents a single or a double bond and R 3 , R 4 , X 2 , X 3 , R 5 are as defined herein.
If ring A is 6-membered heterocyclic ring it is preferred that R is bound to G 1 or G 2 , in particular G 2 :









In said formula, G 1 , G 2 , G 3 and G 4 independently are —CH═, —CH 2 —, —N═, —NH—, S or O, the dotted line represents a single or a double bond and R 3 , R 4 , X 2 , X 3 , R 5 are as defined herein.
Heterocyclic compounds having the following partial structures are preferred:
















Heterocyclic compounds having the following partial structures are particularly preferred:









In said formulae, R and R 2 are as defined herein. If there is more than one radical R 2 , these may be the same or different radicals.
According to a particular embodiment, the partial structures depicted above are fused with a cyclohexane moiety (i.e., n is 1). The same applies to the preferred and particular embodiments disclosed for ring A.
According to one embodiment, R is cyano.
Preferably, R is R 1 —W-A 1 -Q-Y-A 2 -X 1 — and A, R 1 , W, A 1 , Q, Y, A 2 , X 1 , R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 are as defined herein.
R 1 is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl, isopropyl or sec-butyl, a further example being n-butyl or n-pentyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopentylmethyl or cyclohexylmethyl, a further example being cyclopropylmethyl), halogenated C 1 -C 6 -alkyl (e.g. 3-fluoroprop-1-yl, 3-chloroprop-1-yl or 3,3,3-trifluoroprop-1-yl), hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl (e.g. ethoxyethyl), amino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylcarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkyloxycarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylaminocarbonylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylaminocarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylsulfonylamino-C 1 -C 4 -alkyl, (optionally substituted C 6 -C 12 -aryl-C 1 -C 6 -alkyl)amino-C 1 -C 4 -alkyl, optionally substituted C 6 -C 12 -aryl-C 1 -C 4 -alkyl, optionally substituted C 3 -C 12 -heterocyclyl-C 1 -C 4 -alkyl, C 3 -C 12 -cycloalkyl (e.g. cyclopropyl or cyclobutyl), C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, halogenated C 1 -C 6 -alkoxycarbonyl, C 6 -C 12 -aryloxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, (halogenated C 1 -C 4 -alkyl)aminocarbonyl, C 6 -C 12 -arylaminocarbonyl, C 2 -C 6 -alkenyl (e.g. prop-1,2-en-1-yl), C 2 -C 6 -alkynyl, optionally substituted C 6 -C 12 -aryl (e.g. phenyl, a further example being 2-methylphenyl), hydroxy, C 1 -C 6 -alkoxy (e.g. tert-butyloxy), halogenated C 1 -C 6 -alkoxy, C 1 -C 6 -hydroxyalkoxy, C 1 -C 6 -alkoxy-C 1 -C 4 -alkoxy, amino-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylamino-C 1 -C 4 -alkoxy, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylcarbonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -arylcarbonylamino-C 1 -C 4 -alkoxy, C 1 -C 6 -alkoxycarbonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -aryl-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylsulfonylamino-C 1 -C 4 -alkoxy, (halogenated C 1 -C 6 -alkyl)sulfonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -arylsulfonylamino-C 1 -C 4 -alkoxy, (C 6 -C 12 -aryl-C 1 -C 6 -alkyl)sulfonylamino-C 1 -C 4 -alkoxy, C 3 -C 12 -heterocyclylsulfonylamino-C 1 -C 4 -alkoxy, C 3 -C 12 -heterocyclyl-C 1 -C 4 -alkoxy, C 6 -C 12 -aryloxy, C 3 -C 12 -heterocyclyloxy, C 1 -C 6 -alkylthio, halogenated C 1 -C 6 -alkylthio, C 1 -C 6 -alkylamino, (halogenated C 1 -C 6 -alkyl)amino, di-C 1 -C 6 -alkylamino (e.g. dimethylamino), di-(halogenated C 1 -C 6 -alkyl)amino, C 1 -C 6 -alkylcarbonylamino, (halogenated C 1 -C 6 -alkyl)carbonylamino, C 6 -C 12 -arylcarbonylamino, C 1 -C 6 -alkylsulfonylamino, (halogenated C 1 -C 6 -alkyl)sulfonylamino, C 6 -C 12 -arylsulfonylamino or optionally substituted C 3 -C 12 -heterocyclyl (e.g. 3-pyridyl, 2-thienyl, 4-methyl-2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2,5-dimethyl-3-thienyl, 1,2-diazol-4-yl, 1-methyl-1,2-diazol-4-yl, 1-ethyl-1,2-diazol-4-yl, 1-difluormethyl-1,2-diazol-4-yl, 2-methyl-1,3-diazol-4-yl, 1-methyl-1,3-diazol-4-yl, 2-methyl-1,3-thiazol-5-yl, 2,4-dimethyl-1,3-thiazol-5-yl or 3-pyrrolidinyl, a further example being 1-methyl-pyrrol-3-yl, 2-pyridyl, 1-methyl-1,2-diazol-3-yl, 1-methyl-3-trifluoromethyl-1,2-diazol-4-yl, 1,2-dimethyl-1,3-diazol-4-yl, 5-methylisoxazol-3-yl or 1-methyl-1,2,4-triazol-3-yl). Additionally, R 1 may also be tri-(C 1 -C 4 -alkyl)-silyl-C 1 -C 4 -alkyl (e.g. trimethylsilylethyl).
Preferably, R 1 is C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl, isopropyl or sec-butyl, a further example being n-butyl or n-pentyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopentylmethyl or cyclohexylmethyl, a further example being cyclopropylmethyl), halogenated C 1 -C 6 -alkyl (e.g. 3-fluoroprop-1-yl, 3-chloroprop-1-yl or 3,3,3-trifluoroprop-1-yl), C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl (e.g. ethoxyethyl), amino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkyloxycarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylaminocarbonylamino-C 1 -C 4 -alkyl, C 6 -C 12 -aryl-C 1 -C 4 -alkyl, C 3 -C 12 -cycloalkyl (e.g. cyclopropyl or cyclobutyl), C 2 -C 6 -alkenyl (e.g. prop-1,2-en-1-yl), optionally substituted C 6 -C 12 -aryl (e.g. phenyl), hydroxy, C 1 -C 6 -alkylamino, (halogenated C 1 -C 6 -alkyl)amino, di-C 1 -C 6 -alkylamino or optionally substituted C 3 -C 12 -heterocyclyl (e.g. 3-pyridyl, 2-thienyl, 4-methyl-2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2,5-dimethyl-3-thienyl, 1,2-diazol-4-yl, 1-methyl-1,2-diazol-4-yl, 1-ethyl-1,2-diazol-4-yl, 1-difluormethyl-1,2-diazol-4-yl, 2-methyl-1,3-diazol-4-yl, 1-methyl-1,3-diazol-4-yl, 2-methyl-1,3-thiazol-5-yl, 2,4-dimethyl-1,3-thiazol-5-yl or 3-pyrrolidinyl). It is further preferred if R 1 is tri-(C 1 -C 4 -alkyl)-silyl-C 1 -C 4 -alkyl (e.g. trimethylsilylethyl).
In particular, R 1 is C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl, isopropyl or sec-butyl, a further example being n-butyl or n-pentyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopentylmethyl or cyclohexylmethyl, a further example being cyclopropylmethyl), halogenated C 1 -C 6 -alkyl (e.g. 3-fluoroprop-1-yl, 3-chloroprop-1-yl or 3,3,3-trifluoroprop-1-yl), C 3 -C 12 -cycloalkyl (e.g. cyclopropyl or cyclobutyl), C 2 -C 6 -alkenyl (e.g. prop-1,2-en-1-yl), optionally substituted C 6 -C 12 -aryl (e.g. phenyl), or optionally substituted C 3 -C 12 -heterocyclyl (e.g. 3-pyridyl, 2-thienyl, 4-methyl-2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2,5-dimethyl-3-thienyl, 1,2-diazol-4-yl, 1-methyl-1,2-diazol-4-yl, 1-ethyl-1,2-diazol-4-yl, 1-difluormethyl-1,2-diazol-4-yl, 2-methyl-1,3-diazol-4-yl, 1-methyl-1,3-diazol-4-yl, 2-methyl-1,3-thiazol-5-yl, 2,4-dimethyl-1,3-thiazol-5-yl or 3-pyrrolidinyl). In particular, R 1 may also be tri-(C 1 -C 4 -alkyl)-silyl-C 1 -C 4 -alkyl (e.g. trimethylsilylethyl).
In connection with R 1 , substituted C 6 -C 12 -aryl in particular includes C 6 -C 12 -aryl, such as phenyl or naphthyl, substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, amino, C 1 -C 4 -alkylamino, C 1 -C 4 -dialkylamino, morpholino and piperidinyl. The same applies to substituted C 6 -C 12 -aryl in substituted C 6 -C 12 -aryl-C 1 -C 4 -alkyl.
In connection with R 1 , substituted C 3 -C 12 -heterocyclyl in particular includes C 3 -C 12 -heterocyclyl, such as pyridyl, thienyl, diazolyl, quinolinyl, piperidinyl, piperazinyl or morpholinyl (pyrrolyl, isoxazolyl and triazolyl being further examples of such C 3 -C 12 -heterocyclyl), substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxycarbonyl, cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylsulfonyl, amino, C 1 -C 4 -alkylamino, C 1 -C 4 -dialkylamino, C 6 -C 12 -arylamino and C 3 -C 12 -heterocyclyl (e.g., morpholino or piperidinyl). The same applies to substituted C 3 -C 12 -heteroaryl in substituted C 3 -C 12 -heteroaryl-C 1 -C 4 -alkyl.
According to one embodiment, W is —NR 8 — and Y is a bond. According to an alternative embodiment, W is a bond and Y is —NR 9 —. According to a further alternative embodiment, W is a bond and Y is a bond, especially if R 1 is a nitrogen-bound radical, e.g. nitrogen-bound heterocyclyl such as piperazinyl or morpholinyl.
According to one embodiment, Q is —S(O) 2 —. According to an alternative embodiment, Q is —C(O)—.
According to a particular embodiment, —W-A 1 -Q-Y— is —W-A 1 -S(O) 2 —NR 9 —, —NR 8 —S(O) 2 —, -A 1 -S(O) 2 — or —S(O) 2 —. According to a further particular embodiment, —W-A 1 -Q-Y— is —W-A 1 -CO—NR 9 — or —NR 8 —CO—.
A 1 is optionally substituted C 1 -C 4 -alkylene or a bond. In connection with A 1 , substituted C 1 -C 4 -alkylene in particular includes C 1 -C 4 -alkylene substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl and cyano. Preferably, A 1 is a bond. If A 1 is C 1 -C 4 -alkylene, W is preferably —NR 8 —.
A 2 is optionally substituted C 1 -C 4 -alkylene (e.g. 1,2-ethylene or 1,3-propylene), C 1 -C 4 -alkylene-CO—, —CO—C 1 -C 4 -alkylene, C 1 -C 4 -alkylene-O—C 1 -C 4 -alkylene, C 1 -C 4 -alkylene-NR 10 —C 1 -C 4 -alkylene, optionally substituted C 6 -C 12 -arylene, optionally substituted C 6 -C 12 -heteroarylene or a bond. Additionally, A 2 may be optionally substituted C 2 -C 4 -alkenylen or optionally substituted C 2 -C 4 -alkynylene. Preferably, A 2 is optionally substituted C 1 -C 4 -alkylene (e.g. 1,2-ethylene or 1,3-propylene). More preferably, A 2 is C 1 -C 4 -alkylene (e.g. 1,2-ethylene or 1,3-propylene). Alternatively, it is preferred that A 2 is optionally substituted C 6 -C 12 -arylene, in particular C 6 -C 12 -arylene selected from the group consisting of phen-1,4-ylene and phen-1,3-ylene, or optionally substituted C 6 -C 12 -heteroarylene, in particular C 6 -C 12 -heteroarylene selected from the group consisting of pyrid-2,5-ylene and pyrid-2,4-ylene. If A 2 is a bond, X 1 is preferably optionally substituted C 1 -C 4 -alkylene. Alternatively, if A 2 is a bond, X 1 is in particular optionally substituted C 2 -C 4 -alkenylene or optionally substituted C 2 -C 4 -alkynylene.
In connection with A 2 , substituted C 1 -C 4 -alkylene in particular includes C 1 -C 4 -alkylene substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and cyano.
In connection with A 2 , substituted C 2 -C 4 -alkenylene or substituted C 2 -C 4 -alkynylene in particular includes C 2 -C 4 -alkenylene or C 2 -C 4 -alkynylene substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and cyano.
In connection with A 2 , substituted C 6 -C 12 -arylene in particular includes C 6 -C 12 -arylene substituted with 1, 2 or 3 substituents selected from the group consisting of C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxycarbonyl, cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylsulfonyl, amino, C 1 -C 4 -alkylamino, C 1 -C 4 -dialkylamino, C 6 -C 12 -arylamino and C 3 -C 12 -heterocyclyl (e.g., morpholino or piperidinyl).
In connection with A 2 , substituted C 6 -C 12 -heteroarylene in particular includes C 6 -C 12 -heteroarylene substituted with 1, 2 or 3 substituents selected from the group consisting of C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxycarbonyl, cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylsulfonyl, amino, C 1 -C 4 -alkylamino, C 1 -C 4 -dialkylamino, C 6 -C 12 -arylamino and C 3 -C 12 -heterocyclyl (e.g., morpholino or piperidinyl).
X 1 is —O—, —NR 11 —, —S— or optionally substituted C 1 -C 4 -alkylene (e.g. —CH 2 —, a further example being 1,2-ethylene and 1,3-propylene). In connection with X 1 , substituted C 1 -C 4 -alkylene in particular includes C 1 -C 4 -alkylene substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and cyano. Additionally, X 1 may be optionally substituted C 2 -C 4 -alkenylen or optionally substituted C 2 -C 4 -alkynylene (e.g. propynylene). In connection with X 1 , substituted C 2 -C 4 -alkenylene or substituted C 2 -C 4 -alkynylene in particular includes C 2 -C 4 -alkenylene or C 2 -C 4 -alkynylene substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and cyano. Preferably, X 1 is —O—, —NR 11 , —S—. More preferably, X 1 is —O—. Alternatively, it is preferred if X 1 is optionally substituted C 1 -C 4 -alkylene (e.g. —CH 2 —, 1,2-ethylene and 1,3-propylene).
According to a particular embodiment, A 2 is a bond and X 1 is optionally substituted C 1 -C 4 -alkylene, optionally substituted C 2 -C 4 -alkenylene or optionally substituted C 2 -C 4 -alkynylene.
According to a particular embodiment, R 1 —W-A 1 -Q-Y-A 2 -X 1 — is R 1 —S(O) 2 —NH-A 2 -X 1 —, R 1 —NH—S(O) 2 -A 2 -X 1 —, R 1 —C(O)—NH-A 2 -X 1 — or R 1 —NH—C(O)-A 2 -X 1 —.
According to a particular embodiment, the structural element —Y-A 2 -X 1 — comprises at least 2, 3 or 4 atoms in the main chain. According to further particular embodiments the structural element —Y-A 2 -X 1 — has up to 4, 5 or 6 atoms in the main chain, such as 2 to 6, 2 to 5 or 2 to 4 atoms in the main chain, especially 2, 3 or 4 atoms in the main chain.
According to a further particular embodiment, —Y-A 2 -X 1 — is —C 1 -C 4 -alkylene-O— or —NR 9 —C 1 -C 4 -alkylene-O—, with —Y-A 2 -X 1 — preferably having 2 to 6, 3 to 5 and especially 4 atoms in the main chain. Particular examples of —Y-A 2 -X 1 — include —(CH 2 ) 3 —O— and —NR 9 —(CH 2 ) 2 —O—. In this particular embodiment, R 9 is as defined herein and preferably R 9 is hydrogen, C 1 -C 6 -alkyl (e.g. methyl or ethyl) or C 3 -C 12 -cycloalkyl (e.g. cyclopropyl), or R 9 is C 1 -C 4 -alkylene that is bound to a carbon atom in A 2 which is C 1 -C 4 -alkylene.
According to a further particular embodiment, —Y-A 2 -X 1 — is —NR 9 —C 1 -C 4 -alkylene- (e.g. —NH—CH 2 —, a further example being —NH—(CH 2 ) 2 — or —NH—(CH 2 ) 3 —), with —Y-A 2 -X 1 — preferably having 2 to 6, 2 to 5, 2 to 4 and especially 2, 3 or 4 atoms in the main chain. In this particular embodiment, R 9 is as defined herein and preferably R 9 is hydrogen, C 1 -C 6 -alkyl (e.g. methyl or ethyl) or C 3 -C 12 -cycloalkyl (e.g. cyclopropyl); or R 9 is C 1 -C 4 -alkylene that is bound to a carbon atom in X 1 which is C 1 -C 4 -alkylene. If A is a heterocyclic ring, this embodiment of —Y-A 2 -X 1 — is particularly suitable.
According to a further particular embodiment, —Y-A 2 -X 1 — is —NR 9 —C 2 -C 4 -alkenylene- or —NR 9 —C 2 -C 4 -alkynylene- (e.g. —NH—CH 2 —C≡C—), with —Y-A 2 -X 1 — preferably having 2 to 6, 3 to 5 and especially 4 atoms in the main chain. In this particular embodiment, R 9 is as defined herein and preferably is R 9 is hydrogen, C 1 -C 6 -alkyl (e.g. methyl or ethyl) or C 3 -C 12 -cycloalkyl (e.g. cyclopropyl or cyclobutyl). If A is a heterocyclic ring, this embodiment of —Y-A 2 -X 1 — is particularly suitable.
According to a further particular embodiment, —Y-A 2 -X 1 — is —C 1 -C 4 -alkylene- (e.g. —(CH 2 ) 2 —), with —Y-A 2 -X 1 — preferably having 2 to 6, 2 to 5, 2 to 4 and especially 2 atoms in the main chain. If A is a heterocyclic ring, this embodiment of —Y-A 2 -X 1 — is particularly suitable.
According to a further particular embodiment, the structural motif —Y-A 2 -X 1 as disclosed herein is bound to Q being —S(O) 2 — or —C(O)—. Particular examples for this embimdnet include heterocyclic compounds of the invention wherein R is R 1 —S(O) 2 —Y-A 2 -X 1 or R 1 —C(O)—Y-A 2 -X 1 .
The radical R and in particular the radical R 1 —W-A 1 -Q-Y-A 2 -X 1 — may, in principle, be bound to the 5-, 6-, 7- or 8-position of the aminotetraline skeleton:









In said formulae, R 1 , W, A 1 , Q, Y, A 2 , X 1 , R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
Further particular examples include heterocyclic compounds of the above formulae wherein the radical R 1 —W-A 1 -Q-Y-A 2 -X 1 is replaced by the radical —CN.
Aminotetraline derivatives having the radical R 1 —W-A 1 -Q-Y-A 2 -X 1 — (or the radical —CN) in the 5-, 6-, 7-position are preferred.
Particularly preferred are aminotetraline derivatives having the radical R 1 —W-A 1 -Q-Y-A 2 -X 1 — (or the radical —CN) in the 7-position.
In addition to the radical R 1 —W-A 1 -Q-Y-A 2 -X 1 — (or the radical —CN), the aminotetraline derivatives of the invention may have one or more than one further substituent bound to the ring A. In these positions, the skeleton of the aminotetraline derivatives may thus be substituted with one or more than one radical R 2 . If there is more than one radical R 2 , these may be the same or different radicals. In particular, in 5-, 6-, 7- and/or 8-position, the aminotetraline skeleton may be substituted with one or more than one radical R 2 . The aminotetraline derivatives of the invention may therefore be represented by one of the following formulae:









or by corresponding formulae wherein the radical R 1 —W-A 1 -Q-Y-A 2 -X 1 — is replaced by the radical —CN,

wherein R 2a , R 2b , R 2c , R 2d independently have one of the meanings given for R 2 , and R 1 , W, A 1 , Q, Y, A 2 , X 1 , R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.

R 2 is hydrogen, halogen, C 1 -C 6 -alkyl, halogenated C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, —CN, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, optionally substituted C 6 -C 12 -aryl, hydroxy, C 1 -C 6 -alkoxy, halogenated C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxy, C 6 -C 12 -aryl-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylcarbonyloxy, C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl, aminosulfonyl, amino, C 1 -C 6 -alkylamino, C 2 -C 6 -alkenylamino, nitro or optionally substituted C 3 -C 12 -heterocyclyl, or two radicals R 2 together with the ring atoms of A to which they are bound form a 5- or 6 membered ring.
An optionally substituted 5- or 6-membered ring that is formed by two radicals R 2 together with the ring atoms of A to which they are bound is, for instance, a benzene ring.
In connection with R 2 , substituted C 6 -C 12 -aryl in particular includes C 6 -C 12 -aryl, such as phenyl, substituted with 1, 2 or 3 substituents selected from the group consisting of halogen and C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, cyano, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy.
In connection with R 2 , substituted C 3 -C 12 -heterocyclyl in particular includes C 3 -C 12 -heterocyclyl, such as morpholinyl, pyrrolidinyl and piperidinyl, substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, cyano, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy.
Preferably, R 2 is hydrogen, halogen or C 1 -C 6 -alkoxy. In particular, R 2 is hydrogen.
According to a particular embodiment, the aminotetraline derivatives of the invention have one of the following formulae:









or by corresponding formulae wherein the radical R 1 —W-A 1 -Q-Y-A 2 -X 1 — is replaced by the radical —CN,

wherein R 1 , W, A 1 , O, Y, A 2 , X 1 , R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.

In 1-, 2,-3-, 4- and/or 5-position, the aminotetraline derivatives of the invention may be substituted with one or more than one radical R 3 . If there is more than one radical R 3 , these may be the same or different radicals. The aminotetraline derivatives of the invention may therefore be represented by the following formula:









wherein R 3a , R 3b , R 3c , R 3d , R 3e , R 3f independently have one of the meanings given for R 3 , and A, R, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
According to a particular embodiment, the aminotetraline derivatives of the invention have one of the following formulae:









wherein R 3a , R 3b , R 3f independently have the meaning of R 3 and A, R, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are as defined herein.
R 3 is hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, or two radicals R 3 together with the carbon atom to which they are attached form a carbonyl group.
Preferably, R 3 is hydrogen or C 1 -C 6 -alkyl. In particular, R 3 is hydrogen.
R 4a is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl or isopropyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopropylmethyl), halogenated C 1 -C 4 -alkyl (e.g. 2-fluoroethyl or 2,2,2-trifluoroethyl), hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, CH 2 CN, —CHO, C 1 -C 4 -alkylcarbonyl (e.g. methylcarbonyl or isopropylcarbonyl, a further example being ethylcarbonyl), (halogenated C 1 -C 4 -alkyl)carbonyl (e.g. fluoromethylcarbonyl, difluoromethylcarbonyl or trifluoromethylcarbonyl, a further example being 1,1,1-trifluoroeth-2-ylcarbonyl or 1,1,1-trifluoroprop-3-ylcarbonyl), C 6 -C 12 -arylcarbonyl (e.g. phenylcarbonyl), C 1 -C 4 -alkoxycarbonyl (e.g. ethoxycarbonyl or tert-butyloxycarbonyl), C 6 -C 12 -aryloxycarbonyl (e.g. phenoxycarbonyl), C 1 -C 6 -alkylaminocarbonyl, C 2 -C 6 -alkenyl, —C(═NH)NH 2 , —C(═NH)NHCN, C 1 -C 6 -alkylsulfonyl, C 6 -C 12 -arylsulfonyl, amino, —NO or C 3 -C 12 -heterocyclyl.
Preferably, R 4a is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl or isopropyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopropylmethyl), halogenated C 1 -C 4 -alkyl (e.g. 2-fluoroethyl or 2,2,2-trifluoroethyl), amino-C 1 -C 4 -alkyl, CH 2 CN, C 1 -C 4 -alkylcarbonyl (e.g. methylcarbonyl or isopropylcarbonyl), (halogenated C 1 -C 4 -alkyl)carbonyl (e.g. fluoromethylcarbonyl, difluoromethylcarbonyl or trifluoromethylcarbonyl), C 6 -C 12 -arylcarbonyl (e.g. phenylcarbonyl), C 1 -C 4 -alkoxycarbonyl (e.g. ethoxycarbonyl or tert-butyloxycarbonyl), C 6 -C 12 -aryloxycarbonyl (e.g. phenoxycarbonyl), —C(═NH)NH 2 , —C(═NH)NHCN, C 1 -C 6 -alkylsulfonyl, amino, —NO or C 3 -C 12 -heterocyclyl. It is further preferred if R 1 is —CHO.
In particular, R 4a is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl or isopropyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopropylmethyl), halogenated C 1 -C 4 -alkyl (e.g. 2-fluoroethyl or 2,2,2-trifluoroethyl), C 1 -C 4 -alkylcarbonyl (e.g. methylcarbonyl or isopropylcarbonyl), (halogenated C 1 -C 4 -alkyl)carbonyl (e.g. fluoromethylcarbonyl, difluoromethylcarbonyl or trifluoromethylcarbonyl), C 6 -C 12 -arylcarbonyl (e.g. phenylcarbonyl), C 1 -C 4 -alkoxycarbonyl (e.g. ethoxycarbonyl or tert-butyloxycarbonyl), C 6 -C 12 -aryloxycarbonyl (e.g. phenoxycarbonyl). In particular, R 4a may also be —CHO.
R 4b is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, a further example being ethyl), halogenated C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, CH 2 CN, —CHO, C 1 -C 4 -alkylcarbonyl, (halogenated C 1 -C 4 -alkyl)carbonyl, C 6 -C 12 -arylcarbonyl, C 1 -C 4 -alkoxycarbonyl, C 6 -C 12 -aryloxycarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 2 -C 6 -alkenyl, —C(═NH)NH 2 , —C(═NH)NHCN, C 1 -C 6 -alkylsulfonyl, C 6 -C 12 -arylsulfonyl, amino, —NO or C 3 -C 12 -heterocyclyl.
Preferably, R 4b is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, a further example being ethyl).
Alternatively, R 4a , R 4b together are optionally substituted C 1 -C 6 -alkylene (e.g. 1,4-butylene, a further example being 1,3-propylene, 2-fluoro-but-1,4-ylene or 1-oxo-but-1,4-ylene), wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom (e.g. —CH 2 —CH 2 —O—CH 2 —CH 2 —) or —NR 16 .
X 2 is —O—, —NR 6 —, —S—, >CR 12a R 12b or a bond. Preferably, X 2 is >CR 12a R 12b .
X 3 is —O—, —S—, >CR 13a R 13b or a bond. Preferably, X 3 is a bond.
Thus, it is preferred if X 2 is >CR 12a R 12b and X 3 is a bond.
R 12a is hydrogen, optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 3 -C 12 -heterocyclyl-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl or hydroxy. Preferably, R 12a is hydrogen or C 1 -C 6 -alkyl.
R 13a is hydrogen, optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 3 -C 12 -heterocyclyl-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl or hydroxy. Preferably, R 13a is hydrogen or C 1 -C 6 -alkyl.
In connection with R 12a and R 13a , substituted C 1 -C 6 -alkyl in particular includes C 1 -C 6 -alkyl substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, hydroxy, C 1 -C 4 -alkoxy and amino.
In connection with R 12a and R 13a , substituted C 6 -C 12 -aryl in particular includes C 6 -C 12 -aryl, such as phenyl, substituted with 1, 2 or 3 substituents selected from the group consisting of C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, cyano, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy.
R 12b is hydrogen or C 1 -C 6 -alkyl. According to a particular embodiment, R 12b is hydrogen.
R 13b is hydrogen or C 1 -C 6 -alkyl. According to a particular embodiment, R 13b is hydrogen.
Alternatively, R 12a and R 12b , or R 13a and R 13b , together are together are carbonyl or, preferably, optionally substituted C 1 -C 4 -alkylene (e.g. 1,3-propylene), wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom or —NR 14 —.
In connection with R 12a and R 12b , or R 13a and R 13b , substituted C 1 -C 4 -alkylene in particular includes C 1 -C 4 -alkylene substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, cyano, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy.
According to a particular embodiment, R 12a is C 1 -C 6 -alkyl and R 12b is hydrogen or C 1 -C 6 -alkyl, or R 13a is C 1 -C 6 -alkyl and R 13b is hydrogen or C 1 -C 6 -alkyl.
According to a further particular embodiment, R 12a is hydrogen and R 12b is hydrogen, or R 13a is hydrogen and R 13b is hydrogen.
According to a further particular embodiment, R 12a and R 12b together are optionally substituted 1,3-propylene, or R 13a and R 13b together are optionally substituted 1,3-propylene.
R 5 is optionally substituted C 6 -C 12 -aryl (e.g. phenyl, 3-chlorophenyl, 3,4-dichlorophenyl or 2,4-dichlorophenyl, a further example being 2-fluorophenyl, 2-chlorophenyl, 3-fluorophenyl, 3-chlorophenyl; 3-cyanophenyl, 3-methylphenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, 3,4-difluorophenyl, 3,5-difluorophenyl, 3-fluoro-5-chlorophenyl, 3-chloro-4-fluorophenyl), optionally substituted C 3 -C 12 -cycloalkyl (e.g. cyclohexyl) or optionally substituted C 3 -C 12 -heterocyclyl.
In connection with R 5 , substituted C 3 -C 12 -cycloalkyl in particular includes C 3 -C 12 -cycloalkyl, such as cyclopropyl or cyclohexyl, substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, optionally substituted C 1 -C 6 -alkyl, halogenated C 1 -C 6 -alkyl, CN, hydroxy, C 1 -C 6 -alkoxy, halogenated C 1 -C 6 -alkoxy, amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino and C 3 -C 12 -heterocyclyl.
In connection with R 5 , substituted C 6 -C 12 -aryl in particular includes C 6 -C 12 -aryl, such as phenyl, substituted with 1, 2 or 3 substituents selected from the group consisting of halogen (e.g. F, Cl, Br), optionally substituted C 1 -C 6 -alkyl (e.g. methyl), halogenated C 1 -C 6 -alkyl (e.g. trifluoromethyl), CN, hydroxy, C 1 -C 6 -alkoxy (e.g. methoxy), halogenated C 1 -C 6 -alkoxy, amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino and C 3 -C 12 -heterocyclyl.
In connection with R 5 , substituted C 3 -C 12 -heterocyclyl in particular includes C 3 -C 12 -heterocyclyl substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, optionally substituted C 1 -C 6 -alkyl, halogenated C 1 -C 6 -alkyl, CN, hydroxy, C 1 -C 6 -alkoxy, halogenated C 1 -C 6 -alkoxy, amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino and C 3 -C 12 -heterocyclyl.
In connection with R 5 , C 3 -C 12 -heterocyclyl in particular is C 3 -C 12 -heteroaryl.
Preferably, R 5 is optionally substituted C 6 -C 12 -aryl, in particular as in the aminotetraline derivatives of the formula:









wherein A, R, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , n are as defined herein, and R 15a , R 15b , R 15c , R 15d , R 15e independently are hydrogen, halogen (e.g. F, Cl or Br), optionally substituted C 1 -C 6 -alkyl (e.g. methyl), halogenated C 1 -C 6 -alkyl (e.g. trifluoromethyl), CN, hydroxy, C 1 -C 6 -alkoxy (e.g. methoxy), amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino or C 3 -C 12 -heterocyclyl.
According to a particular embodiment, the invention relates to aminotetralin derivatives of the formula:









wherein A, R, R 2 , R 3 , R 4a , R 4b , R 5 , n are as defined herein, R 5 preferably being optionally substituted aryl and in particular optionally substituted phenyl as disclosed herein.
In connection with R 5 or R 15a , R 15b , R 15c , R 15d , R 15e , substituted C 1 -C 6 -alkyl in particular includes C 1 -C 6 -alkyl, especially C 1 -C 4 -alkyl, substituted with 1, 2 or 3 substituents selected from the group consisting of hydroxy, C 1 -C 6 -alkoxy, amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino and C 3 -C 12 -heterocyclyl (e.g. morpholinyl or piperidinyl).
According to a particular embodiment, R 15a , R 15b , R 15d , R 15e are hydrogen and R 15c is different from hydrogen (para-mono-substitution).
According to a further particular embodiment, R 15a , R 15c , R 15d , R 15e are hydrogen and R 15b is different from hydrogen (meta-mono-substitution).
In connection with R 15a , R 15b , R 15c , R 15d , R 15e , C 3 -C 12 -heterocyclyl in particular includes morpholinyl, imidazolyl and pyrazolyl.
The index n is 0, 1 or 2. According to a particular embodiment, n is 1.
R 6 is hydrogen or C 1 -C 6 -alkyl. Preferably, R 6 is hydrogen.
R 7 is hydrogen or C 1 -C 6 -alkyl. Preferably, R 7 is hydrogen.
R 8 is hydrogen or C 1 -C 6 -alkyl. Preferably, R 8 is hydrogen.
R 9 is hydrogen, C 1 -C 6 -alkyl (e.g. methyl or ethyl), C 3 -C 12 -cycloalkyl (e.g. cyclopropyl), amino-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl-C 1 -C 4 -alkyl or C 3 -C 12 -heterocyclyl (e.g. 3-azetidinyl). Preferably, R 9 is hydrogen or C 1 -C 6 -alkyl (e.g. methyl or ethyl).
According to a particular embodiment, R 9 and R 1 together are C 1 -C 4 -alkylene (e.g. 1,3-propylene, a further example being 1,2-ethylene) so as that R 9 and R 1 together with the atom in Q to which R 1 is bound and the nitrogen atom to which R 9 is bound form an heterocyclic ring having, in particular, 4, 5 or 6 ring member atoms (including the nitrogen atom and Q). With W and A 1 both being a bond, such a ring may be represented by the following partial structure:









wherein Q is as defined herein (e.g. S(O) 2 ) and n is 0, 1, 2, 3 or 4.
According to a further particular embodiment, R 9 is C 1 -C 4 -alkylene (e.g. methylene or 1,3-propylene) that is bound to a carbon atom in A 2 and A 2 is C 1 -C 4 -alkylene so that R 9 and at least part of A 2 together with the nitrogen atom to which R 9 is bound form an N-containing heterocyclic ring having, in particular, 4, 5 , 6 or 7 ring member atoms (including the nitrogen atom). Such a ring may be represented by the following partial structure:









wherein R 1 , W, A 1 , Q and X 1 are as defined herein, p is 1 or 2, r is 0, 1 or 2 and q is 0, 1 or 2. In this particular embodiment, X 1 preferably is —O—. Particular combinations of p, r and q include p=1, r=0, q=1; and p=1, r=0, q=0. Alternatively, p is 0, r is 3 and q is 1, with X 1 preferably being —O—.
According to a further particular embodiment, R 9 is C 1 -C 4 -alkylene (e.g. methylene or 1,3-propylene) that is bound to a carbon atom in X 1 and X 1 is C 1 -C 4 -alkylene (e.g. 1,2-ethylene) so that R 9 and at least part of X 1 together with the nitrogen atom to which R 9 is bound form an N-containing heterocyclic ring having, in particular, 4, 5 , 6 or 7 ring member atoms (including the nitrogen atom). With A 2 being a bond, such a ring may be represented by the following partial structure:









wherein R 1 , W, A 1 , Q and X 1 are as defined herein, p is 1 or 2, r is 0, 1 or 2 and q is 0, 1 or 2. Particular combinations of p, r and q include p=1, r=0, q=0.
R 10 is hydrogen, C 1 -C 6 -alkyl or C 1 -C 6 -alkylsulfonyl. Preferably, R 10 is hydrogen.
R 11 is hydrogen or C 1 -C 6 -alkyl. Preferably, R 11 is hydrogen.
Alternatively, R 9 , R 11 together are C 1 -C 4 -alkylene (e.g. ethylene).
R 14 is hydrogen or C 1 -C 6 -alkyl. Preferably, R 14 is hydrogen.
R 15 is hydrogen or C 1 -C 6 -alkyl. Preferably, R 15 is hydrogen.
R 16 is hydrogen or C 1 -C 6 -alkyl. Preferably, R 16 is hydrogen.
Particular embodiments of aminotetraline derivatives of the invention result if
A is a 5- or 6-membered ring; R is R 1 —W-A 1 -Q-Y-A 2 -X 1 — or —CN; R 1 is hydrogen, C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl, halogenated C 1 -C 6 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylcarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkyloxycarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylaminocarbonylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylaminocarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylsulfonylamino-C 1 -C 4 -alkyl, (optionally substituted C 6 -C 12 -aryl-C 1 -C 6 -alkyl)amino-C 1 -C 4 -alkyl, optionally substituted C 6 -C 12 -aryl-C 1 -C 4 -alkyl, optionally substituted C 3 -C 12 -heterocyclyl-C 1 -C 4 -alkyl, C 3 -C 12 -cycloalkyl, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, halogenated C 1 -C 6 -alkoxycarbonyl, C 6 -C 12 -aryloxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, (halogenated C 1 -C 4 -alkyl)aminocarbonyl, C 6 -C 12 -arylaminocarbonyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, optionally substituted C 6 -C 12 -aryl, hydroxy, C 1 -C 6 -alkoxy, halogenated C 1 -C 6 -alkoxy, C 1 -C 6 -hydroxyalkoxy, C 1 -C 6 -alkoxy-C 1 -C 4 -alkoxy, amino-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylamino-C 1 -C 4 -alkoxy, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylcarbonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -arylcarbonylamino-C 1 -C 4 -alkoxy, C 1 -C 6 -alkoxycarbonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -aryl-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylsulfonylamino-C 1 -C 4 -alkoxy, (halogenated C 1 -C 6 -alkyl)sulfonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -arylsulfonylamino-C 1 -C 4 -alkoxy, (C 6 -C 12 -aryl-C 1 -C 6 -alkyl)sulfonylamino-C 1 -C 4 -alkoxy, C 3 -C 12 -heterocyclylsulfonylamino-C 1 -C 4 -alkoxy, C 3 -C 12 -heterocyclyl-C 1 -C 4 -alkoxy, C 6 -C 12 -aryloxy, C 3 -C 12 -heterocyclyloxy, C 1 -C 6 -alkylthio, halogenated C 1 -C 6 -alkylthio, C 1 -C 6 -alkylamino, (halogenated C 1 -C 6 -alkyl)amino, di-C 1 -C 6 -alkylamino, di-(halogenated C 1 -C 6 -alkyl)amino, C 1 -C 6 -alkylcarbonylamino, (halogenated C 1 -C 6 -alkyl)carbonylamino, C 6 -C 12 -arylcarbonylamino, C 1 -C 6 -alkylsulfonylamino, (halogenated C 1 -C 6 -alkyl)sulfonylamino, C 6 -C 12 -arylsulfonylamino or optionally substituted C 3 -C 12 -heterocyclyl; W is —NR 8 — or a bond; A 1 is optionally substituted C 1 -C 4 -alkylene or a bond; Q is —S(O) 2 — or —C(O)—; Y is —NR 9 — or a bond; A 2 is optionally substituted C 1 -C 4 -alkylene, C 1 -C 4 -alkylene-CO—, —CO—C 1 -C 4 -alkylene, C 1 -C 4 -alkylene-O—C 1 -C 4 -alkylene, C 1 -C 4 -alkylene-NR 10 —C 1 -C 4 -alkylene, optionally substituted C 6 -C 12 -arylene, optionally substituted C 6 -C 12 -heteroarylene or a bond; X 1 is —O—, —NR 11 —, —S—, optionally substituted C 1 -C 4 -alkylene; R 2 is hydrogen, halogen, C 1 -C 6 -alkyl, halogenated C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, —CN, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, optionally substituted C 6 -C 12 -aryl, hydroxy, C 1 -C 6 -alkoxy, halogenated C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxy, C 6 -C 12 -aryl-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylcarbonyloxy, C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl, aminosulfonyl, amino, C 1 -C 6 -alkylamino, C 2 -C 6 -alkenylamino, nitro or optionally substituted C 3 -C 12 -heterocyclyl, or two radicals R 2 together with the ring atoms of A to which they are bound form a 5- or 6 membered ring; R 3 is hydrogen, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy, or two radicals R 3 together with the carbon atom to which they are attached form a carbonyl group; R 4a is hydrogen, C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl, halogenated C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, CH 2 CN, —CHO, C 1 -C 4 -alkylcarbonyl, (halogenated C 1 -C 4 -alkyl)carbonyl, C 6 -C 12 -arylcarbonyl, C 1 -C 4 -alkoxycarbonyl, C 6 -C 12 -aryloxycarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 2 -C 6 -alkenyl, —C(═NH)NH 2 , —C(═NH)NHCN, C 1 -C 6 -alkylsulfonyl, C 6 -C 12 -arylsulfonyl, amino, —NO or C 3 -C 12 -heterocyclyl; R 4b is hydrogen, C 1 -C 6 -alkyl, halogenated C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, CH 2 CN, —CHO, C 1 -C 4 -alkylcarbonyl, (halogenated C 1 -C 4 -alkyl)carbonyl, C 6 -C 12 -arylcarbonyl, C 1 -C 4 -alkoxycarbonyl, C 6 -C 12 -aryloxycarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 2 -C 6 -alkenyl, —C(═NH)NH 2 , —C(═NH)NHCN, C 1 -C 6 -alkylsulfonyl, C 6 -C 12 -arylsulfonyl, amino, —NO or C 3 -C 12 -heterocyclyl; or R 4a , R 4b
together are optionally substituted C 1 -C 6 -alkylene, wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom or —NR 16 ;
X 2 is —O—, —NR 6 —, —S—, >CR 12a R 12b or a bond; X 3 is —O—, —NR 7 —, —S—, >CR 13a R 13b or a bond; R 5 is optionally substituted C 6 -C 12 -aryl, optionally substituted C 3 -C 12 -cycloalkyl or optionally substituted C 3 -C 12 -heterocyclyl; n is 0, 1 or 2; R 6 is hydrogen or C 1 -C 6 -alkyl; R 7 is hydrogen or C 1 -C 6 -alkyl; R 9 is hydrogen or C 1 -C 6 -alkyl; R 9 is hydrogen, C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl, amino-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl-C 1 -C 4 -alkyl; or R 9 , R 1
together are C 1 -C 4 -alkylene; or
R 9 is C 1 -C 4 -alkylene that is bound to a carbon atom in A 2 and A 2 is C 1 -C 4 -alkylene or to a carbon atom in X 1 and X 1 is C 1 -C 4 -alkylene; R 10 is hydrogen, C 1 -C 6 -alkyl or C 1 -C 6 -alkylsulfonyl; R 11 is hydrogen or C 1 -C 6 -alkyl, or R 9 , R 11
together are C 1 -C 4 -alkylene,
R 12a is hydrogen, optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 3 -C 12 -heterocyclyl-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl or hydroxy; R 12b is hydrogen or C 1 -C 6 -alkyl, or R 12a , R 12b
together are carbonyl or optionally substituted C 1 -C 4 -alkylene, wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom or —NR 14 —;
R 13a is hydrogen, optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 3 -C 12 -heterocyclyl-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl or hydroxy; R 13b is hydrogen or C 1 -C 6 -alkyl, or R 13a , R 13b
together are carbonyl or optionally substituted C 1 -C 4 -alkylene, wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom or —NR 15 —;
R 14 is hydrogen or C 1 -C 6 -alkyl; R 15 is hydrogen or C 1 -C 6 -alkyl; and R 16 is hydrogen or C 1 -C 6 -alkyl, or if one or more of said variables A, R, R 1 , W, A 1 , Q, Y, A 2 , X 1 , R 2 , R 3 , R 4 , X 2 , X 3 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , n are defined more precidely as disclosed herein.

Further particular embodiments of aminotetraline derivatives of the invention result if
A is a benzene ring; R is R 1 —W-A 1 -Q-Y-A 2 -X 1 —; R 1 is C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, n-pentyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopropylmethyl, cyclopentylmethyl, cyclohexylmethyl), halogenated C 1 -C 6 -alkyl (e.g. 3-fluoroprop-1-yl, 3-chloroprop-1-yl, 3,3,3-trifluoroprop-1-yl), tri-(C 1 -C 4 -alkyl)-silyl-C 1 -C 4 -alkyl (e.g. trimethylsilylethyl), C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl (e.g. ethoxyethyl), C 3 -C 12 -cycloalkyl (e.g. cyclopropyl, cyclobutyl, cyclohexyl), C 2 -C 6 -alkenyl (e.g. prop-1,2-en-1-yl), optionally substituted C 6 -C 12 -aryl (e.g. phenyl, 2-methylphenyl), or optionally substituted C 3 -C 12 -heterocyclyl (e.g. 1-methyl-pyrrol-3-yl, 2-pyridyl, 3-pyridyl, 2-thienyl, 4-methyl-2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2,5-dimethyl-3-thienyl, 1,2-diazol-4-yl, 1-methyl-1,2-diazol-3-yl, 1-methyl-1,2-diazol-4-yl, 1-ethyl-1,2-diazol-4-yl, 1-difluormethyl-1,2-diazol-4-yl, 1-methyl-3-trifluoromethyl-1,2-diazol-4-yl, 2-methyl-1,3-diazol-4-yl, 1-methyl-1,3-diazol-4-yl, 1,2-dimethyl-1,3-diazol-4-yl, 5-methylisoxazol-3-yl, 2-methyl-1,3-thiazol-5-yl, 2,4-dimethyl-1,3-thiazol-5-yl, 1-methyl-1,2,4-triazol-3-yl, 3-pyrrolidinyl); W is a bond; A 1 is a bond; Q is —S(O) 2 — or —C(O)—; Y is —NR 9 — or a bond; A 2 is C 1 -C 4 -alkylene (e.g. 1,2-ethylene, 1,3-propylene) or a bond; X 1 is —O— or optionally substituted C 1 -C 4 -alkylene (e.g. methylene, 1,2-ethylene, 1,3-propylene) or C 2 -C 4 -alkynylene (e.g. prop-1,2-yn-1,3-ylene); R 2 is hydrogen; R 3 is hydrogen; R 4a is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl, isopropyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopropylmethyl), halogenated C 1 -C 4 -alkyl (e.g. 2-fluoroethyl, 2,2,2-trifluoroethyl), —CHO, C 1 -C 4 -alkylcarbonyl (e.g. methylcarbonyl, ethylcarbonyl, isopropylcarbonyl), (halogenated C 1 -C 4 -alkyl)carbonyl (e.g. fluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 1,1,1-trifluoroeth-2-ylcarbonyl, 1,1,1-trifluoroprop-3-ylcarbonyl), C 6 -C 12 -arylcarbonyl (e.g. phenylcarbonyl), C 1 -C 4 -alkoxycarbonyl (e.g. ethoxycarbonyl, tert-butyloxycarbonyl), C 6 -C 12 -aryloxycarbonyl (e.g. phenoxycarbonyl); R 4b is hydrogen or C 1 -C 6 -alkyl (e.g. methyl, ethyl); or R 4a , R 4b
together are optionally substituted C 1 -C 6 -alkylene (e.g. 1,3-propylene, 1,4-butylene, 2-fluoro-but-1,4-ylene, 1-oxo-but-1,4-ylene), wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom (e.g. —CH 2 —CH 2 —O—CH 2 —CH 2 —);
X 2 is CR 12a R 12b ; X 3 is a bond; R 5 is optionally substituted phenyl (e.g. phenyl, 2-fluorophenyl, 2-chlorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3-cyanophenyl, 3-methylphenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, 3,4-difluorophenyl, 3,5-difluorophenyl, 3-fluoro-5-chlorophenyl, 3-chloro-4-fluorophenyl, 3,4-dichlorophenyl, 2,4-dichlorophenyl) or optionally substituted C 3 -C 12 -cycloalkyl (e.g. cyclohexyl); n is 1; R 9 is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, ethyl) or C 3 -C 12 -cycloalkyl [cyclopropyl), or R 9 , R 1
together are C 1 -C 4 -alkylene (e.g. 1,3-propylene); or
R 9 is C 1 -C 4 -alkylene (e.g. methylene, 1,3-propylene) that is bound to a carbon atom in A 2 and A 2 is C 1 -C 4 -alkylene (e.g. 1,2-ethylene, 1,3-propylene) or to a carbon atom in X 1 and X 1 is C 1 -C 4 -alkylene (e.g. 1,2-ethylene); R 12a is hydrogen; and R 12b is hydrogen.

Further particular embodiments of aminotetraline derivatives of the invention result if
A is a benzene ring; R is R 1 —W-A 1 -Q-Y-A 2 -X 1 —; R 1 is C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl, isopropyl or sec-butyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopentylmethyl or cyclohexylmethyl), halogenated C 1 -C 6 -alkyl (e.g. 3-fluoroprop-1-yl, 3-chloroprop-1-yl or 3,3,3-trifluoroprop-1-yl), C 3 -C 12 -cycloalkyl (e.g. cyclopropyl or cyclobutyl), C 2 -C 6 -alkenyl (e.g. prop-1,2-en-1-yl), optionally substituted C 6 -C 12 -aryl (e.g. phenyl), or optionally substituted C 3 -C 12 -heterocyclyl (e.g. 3-pyridyl, 2-thienyl, 4-methyl-2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2,5-dimethyl-3-thienyl, 1,2-diazol-4-yl, 1-methyl-1,2-diazol-4-yl, 1-ethyl-1,2-diazol-4-yl, 1-difluormethyl-1,2-diazol-4-yl, 2-methyl-1,3-diazol-4-yl, 1-methyl-1,3-diazol-4-yl, 2-methyl-1,3-thiazol-5-yl, 2,4-dimethyl-1,3-thiazol-5-yl or 3-pyrrolidinyl); W is a bond; A 1 is a bond; Q is —S(O) 2 — or —C(O)—; Y is —NR 9 — or a bond; A 2 is C 1 -C 4 -alkylene (e.g. methylene or 1,3-propylene) or a bond; X 1 is —O— or optionally substituted C 1 -C 4 -alkylene (e.g. methylene); R 2 is hydrogen; R 3 is hydrogen; R 4a is hydrogen, C 1 -C 6 -alkyl (e.g. methyl, ethyl, n-propyl or isopropyl), C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl (e.g. cyclopropylmethyl), halogenated C 1 -C 4 -alkyl (e.g. 2-fluoroethyl or 2,2,2-trifluoroethyl), C 1 -C 4 -alkylcarbonyl (e.g. methylcarbonyl or, isopropylcarbonyl), (halogenated C 1 -C 4 -alkyl)carbonyl (e.g. fluoromethylcarbonyl, difluoromethylcarbonyl or trifluoromethylcarbonyl), C 6 -C 12 -arylcarbonyl (e.g. phenylcarbonyl), C 1 -C 4 -alkoxycarbonyl (e.g. ethoxycarbonyl or tert-butyloxycarbonyl), C 6 -C 12 -aryloxycarbonyl (e.g. phenoxycarbonyl); R 4b is hydrogen or C 1 -C 6 -alkyl (e.g. methyl); X 2 is CR 12a R 12b ; X 3 is a bond; R 5 is optionally substituted phenyl (e.g. phenyl, 3-chlorophenyl, 3,4-dichlorophenyl or 2,4-dichlorophenyl); n is 1; R 6 is hydrogen; R 7 is hydrogen; R 8 is hydrogen; R 9 is hydrogen or alkyl (e.g. methyl or ethyl); or R 9 , R 1
together are C 1 -C 4 -alkylene (e.g. 1,3-propylene); or
R 9 is C 1 -C 4 -alkylene (e.g. methylene or 1,3-propylene) that is bound to a carbon atom in A 2 and A 2 is C 1 -C 4 -alkylene; R 13 is hydrogen; R 11 is hydrogen; R 12a is hydrogen; and R 12b is hydrogen.

Particular compounds of the present invention are the aminotetraline derivatives disclosed in preparation examples and physiologically tolerated acid addition salts thereof. These include for each preparation example the exemplified compound as well as the corresponding free base and any other physiologically tolerated acid addition salts of the free base (if the exemplified compound is a salt), or any physiologically tolerated acid addition salt of the free base (if the exemplified compound is a free base). These further include enantiomers, diastereomers, tautomers and any other isomeric forms of said compounds, be they explicitly or implicitly disclosed.
The compounds of the formula (I) can be prepared by analogy to methods which are well known in the art. Suitable methods for the preparation of compounds of formula (I) is out-lined in the following schemes.
The process depicted in scheme 1 is useful for obtaining aminotetralines, wherein X 1 is —O— or —S—.









As shown in scheme 1, the compound of general formula I readily undergoes enamine alkylation to give the compound of general formula 3.
In scheme 1, the variables X 2 , X 3 , R 5 are as defined herein and L a suitable protecting group (e.g. L=Me). The process depicted in scheme 1 is also useful for obtaining aminotetralines, wherein X is optionally substituted alkylene. In this case, L is a group that represents, or can be converted into, the desired side chain R 1 —W-A 1 -Q-Y-A 2 -.
Alternatively, compounds of formula 3 can be prepared as described in scheme 2.









As shown in scheme 2, the compound of general formula 4 readily undergoes alkylation to give the compound of general formula 5. Conversion to the acid chloride and subsequent ring closure with ethylene in the presence of a Lewis acid (e.g. AlCl 3 ) affords compound 3 (e.g. J. Het. Chem., 23 (2), 343, 1986 and Bioorg. Med. Chem. Let, 17 (22), 6160, 2007)
The variables X 2 , X 3 , R 5 are as defined herein and L, L 1 are a suitable protecting group (e.g. L, L 1 =Me). Compounds 3 can be further converted to compounds of the general formula (I).
The process depicted in scheme 3 is useful for obtaining aminotetralines, wherein X 1 is —O— or —S—, A 2 is optionally substituted alkylene, Y is —NR 9 —, and Q is —S(O) 2 .









In scheme 3, the variables R 1 , W, A 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 9 , X 2 , X 3 are as defined herein and L 2 is a suitable protecting group (e.g. L 2 =COOEt).
The process depicted in scheme 4 is useful for obtaining aminotetralines, wherein X 1 is methylene, A 2 is a bond, Y is —NR 9 —, and Q is —S(O) 2 .









Alternatively to triflate 19, the corresponding bromide or iodide can be used to prepare compound 20.
In scheme 4, the variables R 1 , W, A 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 9 , X 2 , X 3 are as defined herein, and L 3 is a suitable protecting group (e.g. L 3 =COO t Bu).
The process depicted in scheme 5 is useful for obtaining aminotetralines, wherein X 1 is optionally substituted alkylene, A 2 is optionally substituted alkylene or a bond, Y is —NR 9 —, and Q is —S(O) 2 .









Instead of the trifluoroborate 66, the corresponding 9-borabicyclo[3.3.1]non-9-yl derivative can be used to prepare compound 26.
In scheme 5, the variables R 1 , W, A 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 9 , X 2 , X 3 , A 2 are as defined herein, and L 3 is a suitable protecting group (e.g. L 3 =COO t Bu).
The process depicted in scheme 6 is useful for obtaining aminotetralines, wherein X is —NR 11 —, A 2 is optionally substituted alkylene, Y is —NR 9 —, and Q is —S(O) 2 .









In scheme 5, the variables R 1 , W, A 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 9 , X 2 , X 3 , A 2 are as defined herein, and L 4 is a suitable protecting group.
The process depicted in the following schemes is useful for obtaining compounds of the general formula (I) in which A is a heterocycle.









As shown in scheme 7, the compound of general formula 34 readily undergoes condensation with dimethylformamide dimethyl acetal to give the compound of general formula 35.









As shown in the above scheme 8, the intermediate of general formula 35 reacts with various nucleophiles of general formula H 2 N—NH—R in an alcoholic solvent preferably methanol or ethanol at a temperature of about 20° to 80° C. to obtain the compounds of general formulae 36 and 37. In case of monosubstituted hydrazines regioisomeric products are formed. Compounds 36 and 37 can be transformed to compounds of the general formula (I) as depicted in Scheme 9.
In scheme 8, the variable R is as defined herein.









Alkylation of 38 can proceed via an enamine as described in scheme 1, or via an enolate. Reductive amination of 39 leads to 40. Alkylation or acylation of 40 affords 41. In scheme 9, the variables R, R 4a , R 4b , R 5 , X 2 , X 3 are as defined herein.









As shown in scheme 10, the reaction of compound of general formula 34 with hydroxyl (tosyloxy)iodobenzene gives the compound of formula 42. Reaction of compound of general formula 42 with 1,3-nucleophiles under appropriate conditions yield the compound of general formula 43. Further transformation to compounds of general formula 46 occurs as described in Scheme 9.
In scheme 10, the variables R, R 4a , R 4b , R 5 , X 2 , X 3 are as defined herein.









As shown in scheme 11, the condensation of compound of general formula 35 with reagent of general formula 49 and ammonia acetate in refluxing acetic acid give compound of general formula 47, which can be further transformed to compounds of general formula 48.
In scheme 11, the variables R, R 4a , R 4b , R 5 , X 2 , X 3 are as defined herein.









As shown in scheme 12, the cyclocondensation of intermediate of general formula 35 with the 1,3-nucleophiles of general formula 50 in the presence of suitable organic or inorganic bases such as KOH, NaOH, NaHCO3, sodium ethoxide, sodium methoxide, triethyl amine and diisopropyl ethyl amine in an alcoholic solvent, preferably ethanol or methanol, at a temperature of about 20° to 80° C. yield the compound of general formula 51, which can be transformed further to give compounds of general formula 52.
In scheme 12, the variables R, R 4a , R 4b , R 5 , X 2 , X 3 are as defined herein.









As shown in scheme 13, the intermediate of general formula 53 readily can undergo condensation with dimethylformamide dimethyl acetal to give the compound of general formula 54, which reacts with various nucleophiles of general formula H 2 N—NH—R in an alcoholic solvent, preferably methanol or ethanol, at a temperature of about 20° to 80° C. to afford the compound of general formula 55 and 56. Compounds 55 and 56 can be trans-formed to compounds of the general formula (I) as depicted in the previous schemes.
In scheme 13, the variables R, R 4a , R 4b , R 5 , X 2 , X 3 are as defined herein.









As shown in scheme 14, the reaction of compound of general formula 53 with hydroxyl (tosyloxy)iodobenzene gives the compound of formula 59, which reacts with 1,3-nucleophiles under appropriate conditions to yield the compound of general formula 60. Further transformation to compounds of general formula 62 occurs as described in the previous schemes.
In scheme 14, the variables R, R 4a , R 4b , R 5 , X 2 , X 3 are as defined herein.









As shown in scheme 15, the cyclocondensation of intermediate of general formula 54 with the 1,3-nucleophiles of general formula 50 in the presence of suitable organic or inorganic bases such as KOH, NaOH, NaHCO 3 , sodium ethoxide, sodium methoxide, triethyl amine and diisopropyl ethyl amine in an alcoholic solvent, preferably ethanol or methanol, at a temperature of about 20° to 80° C. yields the compound of general formula 63, which can be transformed further to give compounds of general formula 65 as described in the previous schemes.
In scheme 15, the variables R, R 4a , R 4b , R 5 , X 2 , X 3 are as defined herein.
The acid addition salts of the aminotetraline derivatives of formula (I) are prepared in a customary manner by mixing the free base with a corresponding acid, optionally in solution in an organic solvent, for example a lower alcohol, such as methanol, ethanol or propanol, an ether, such as methyl tert-butyl ether or diisopropyl ether, a ketone, such as acetone or methyl ethyl ketone, or an ester, such as ethyl acetate.
The aminotetraline derivatives of formula (II)









wherein L is an amino-protecting group, Y is NR 9 , and A 2 , R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , R 5 , n are defined as above are useful as intermediates in the preparation of GlyT1 inhibitors, in particular those of formula (I).
Suitable amino-protecting groups are well known in the art such as those described in Protective Groups in Organic Chemistry, ed. J. F. W. McOmie, Plenum Press, 1973; and T. W. Greene & P. G. M. Wuts, Protective Groups in Organic Synthesis, John Wiley & Sons, 1991.
According to a particular embodiment, L is optionally substituted alkylcarbonyl (e.g., tert-butylcarbonyl), optionally substituted arylcarbonyl, optionally substituted arylalkycarbonyl (e.g., benzylcarbonyl), optionally substituted alkoxycarbonyl (e.g., methoxycarbonyl or tert-butyloxycarbonyl), optionally substituted aryloxycarbonyl (e.g. phenoxycarbonyl) or optionally substituted arylalkoxycarbonyl.
The compounds of the formula (I) are capable of inhibiting the activity of glycine transporter, in particular glycine transporter 1 (GlyT1).
The utility of the compounds in accordance with the present invention as inhibiting the glycine transporter activity, in particular GlyT1 activity, may be demonstrated by methodology known in the art. For instance, human GlyT1c expressing recombinant hGlyT1c 5 CHO cells can be used for measuring glycine uptake and its inhibition (IC 50 ) by a compound of formula (I).
Amongst the compounds of the formula (I) those are preferred which achieve effective inhibition at low concentrations. In particular, compounds of the formula (I) are preferred which inhibit glycine transporter 1 (GlyT1) at a level of IC 50 <1 μMol, more preferably at a level of IC 50 <0.5 μMol, particularly preferably at a level of IC 50 <0.2 μMol and most preferably at a level of IC 50 <0.1 μMol.
The compounds of the formula (I) according to the present invention are thus useful as pharmaceuticals.
The present invention therefore also relates to pharmaceutical compositions which comprise an inert carrier and a compound of the formula (I).
The present invention also relates to the use of the compounds of the formula (I) in the manufacture of a medicament for inhibiting the glycine transporter GlyT1, and to corresponding methods of inhibiting the glycine transporter GlyT1.
The NMDA receptor is central to a wide range of CNS processes, and its role in a variety of diseases in humans or other species has been described. GlyT1 inhibitors slow the removal of glycine from the synapse, causing the level of synaptic glycine to rise. This in turn increases the occupancy of the glycine binding site on the NMDA receptor, which increases activation of the NMDA receptor following glutamate release from the presynaptic terminal. Glycine transport inhibitors and in particular inhibitors of the glycine trans-porter GlyT1 are thus known to be useful in treating a variety of neurologic and psychiatric disorders. Further, glycine A receptors play a role in a variety of diseases in humans or other species. Increasing extracellular glycine concentrations by inhibiting glycine trans-port may enhance the activity of glycine A receptors. Glycine transport inhibitors and in particular inhibitors of the glycine transporter GlyT1 are thus useful in treating a variety of neurologic and psychiatric disorders.
The present invention thus further relates to the use of the compounds of the formula (I) for the manufacture of a medicament for treating a neurologic or psychiatric disorder, and to corresponding methods of treating said disorders.
According to a particular embodiment, the disorder is associated with glycinergic or glutamatergic neurotransmission dysfunction.
According to a further particular embodiment, the disorder is one or more of the following conditions or diseases: schizophrenia or a psychotic disorder including schizophrenia (paranoid, disorganized, catatonic or undifferentiated), schizophreniform disorder, schizoaffective disorder, delusional disorder, brief psychotic disorder, shared psychotic disorder, psychotic disorder due to a general medical condition and substance-induced psychotic disorder, including both the positive and the negative symptoms of schizophrenia and other psychoses; cognitive disorders including dementia (associated with Alzheimer's disease, ischemia, multi-infarct dementia, trauma, vascular problems or stroke, HIV disease, Parkinson's disease, Huntington's disease, Pick's disease, Creutzfeldt-Jacob disease, perinatal hypoxia, other general medical conditions or substance abuse); delirium, amnestic disorders or cognitive impairment including age related cognitive decline; anxiety disorders including acute stress disorder, agoraphobia, generalized anxiety disorder, obsessive-compulsive disorder, panic attack, panic disorder, post-traumatic stress disorder, separation anxiety disorder, social phobia, specific phobia, substance-induced anxiety disorder and anxiety due to a general medical condition; substance-related disorders and addictive behaviors (including substance-induced delirium, persisting dementia, persisting amnestic disorder, psychotic disorder or anxiety disorder; tolerance, dependence or withdrawal from substances including alcohol, amphetamines, cannabis, cocaine, hallucinogens, inhalants, nicotine, opioids, phencyclidine, sedatives, hypnotics or anxiolytics); obesity, bulimia nervosa and compulsive eating disorders; bipolar disorders, mood disorders including depressive disorders; depression including unipolar depression, seasonal depression and post-partum depression, premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PDD), mood disorders due to a general medical condition, and substance-induced mood disorders; learning disorders, pervasive developmental disorder including autistic disorder, attention deficit disorders including attention-deficit hyperactivity disorder (ADHD) and conduct disorder; movement disorders, including akinesias and akinetic-rigid syndromes (including Parkinson's disease, drug-induced parkinsonism, postencephalitic parkinsonism, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, parkinsonism-ALS dementia complex and basal ganglia calcification), medication-induced parkinsonism (such as neuroleptic-induced parkinsonism, neuroleptic malignant syndrome, neuroleptic-induced acute dystonia, neuroleptic-induced acute akathisia, neuroleptic-induced tardive dyskinesia and medication-induced postural tremor), Gilles de la Tourette's syndrome, epilepsy, muscular spasms and disorders associated with muscular spasticity or weakness including tremors; dyskinesias [including tremor (such as rest tremor, postural tremor and intention tremor), chorea (such as Sydenham's chorea, Huntington's disease, benign hereditary chorea, neuroacanthocytosis, symptomatic chorea, drug-induced chorea and hemiballism), myoclonus (including generalised myoclonus and focal myoclonus), tics (including simple tics, complex tics and symptomatic tics), and dystonia (including generalised dystonia such as iodiopathic dystonia, drug-induced dystonia, symptomatic dystonia and paroxymal dystonia, and focal dystonia such as blepharospasm, oromandibular dystonia, spasmodic dysphonia, spasmodic torticollis, axial dystonia, dystonic writers cramp and hemiplegic dystonia)]; urinary incontinence; neuronal damage including ocular damage, retinopathy or macular degeneration of the eye, tinnitus, hearing impairment and loss, and brain edema; emesis; and sleep disorders including insomnia and narcolepsy.
According to a further particular embodiment, the disorder is pain, in particular chronic pain and especially neuropathic pain.
Pain can be classified as acute and chronic pain. Acute pain and chronic pain differ in their etiology, pathophysiology, diagnosis and treatment.
Acute pain, which occurs following tissue injury, is self-limiting, serves as an alert to ongoing tissue damage and following tissue repair it will usually subside. There are minimal psychological symptoms associated with acute pain apart from mild anxiety. Acute pain is nociceptive in nature and occurs following chemical, mechanical and thermal stimulation of A-delta and C-polymodal pain receptors.
Chronic pain, on the other hand, serves no protective biological function. Rather than being the symptom of tissue damage it is a disease in its own right. Chronic pain is unrelenting and not self-limiting and can persist for years, perhaps decades after the initial injury. Chronic pain can be refractory to multiple treatment regimes. Psychological symptoms associated with chronic pain include chronic anxiety, fear, depression, sleeplessness and impairment of social interaction. Chronic non-malignant pain is predominantly neuropathic in nature and involves damage to either the peripheral or central nervous systems.
Acute pain and chronic pain are caused by different neuro-physiological processes and therefore tend to respond to different types of treatments. Acute pain can be somatic or visceral in nature. Somatic pain tends to be a well localised, constant pain and is described as sharp, aching, throbbing or gnawing. Visceral pain, on the other hand, tends to be vague in distribution, paroxysmal in nature and is usually described as deep, aching, squeezing or colicky in nature. Examples of acute pain include post-operative pain, pain associated with trauma and the pain of arthritis. Acute pain usually responds to treatment with opioids or non-steroidal anti-inflammatory drugs.
Chronic pain, in contrast to acute pain, is described as burning, electric, tingling and shooting in nature. It can be continuous or paroxysmal in presentation. The hallmarks of chronic pain are chronic allodynia and hyperalgesia. Allodynia is pain resulting from a stimulus that normally does not ellicit a painful response, such as a light touch. Hyperalgesia is an increased sensitivity to normally painful stimuli. Primary hyperalgesia occurs immediately within the area of the injury. Secondary hyperalgesia occurs in the undamaged area surrounding the injury. Examples of chronic pain include complex regional pain syndrome, pain arising from peripheral neuropathies, post-operative pain, chronic fatigue syndrome pain, tension-type headache, pain arising from mechanical nerve injury and severe pain associated with diseases such as cancer, metabolic disease, neurotropic viral disease, neurotoxicity, inflammation, multiple sclerosis or any pain arising as a consequence of or associated with stress or depressive illness.
Although opioids are cheap and effective, serious and potentially life-threatening side effects occur with their use, most notably respiratory depression and muscle rigidity. In addition the doses of opioids which can be administered are limited by nausea, emesis, constipation, pruritis and urinary retention, often resulting in patients electing to receive suboptimal pain control rather than suffer these distressing side-effects. Furthermore, these side-effects often result in patients requiring extended hospitalisation. Opioids are highly addictive and are scheduled drugs in many territories.
The compounds of formula (I) are particularly useful in the treatment of schizophrenia, bipolar disorder, depression including unipolar depression, seasonal depression and postpartum depression, premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PDD), learning disorders, pervasive developmental disorder including autistic disorder, attention deficit disorders including Attention-Deficit/Hyperactivity Disorder, tic disorders including Tourette's disorder, anxiety disorders including phobia and post traumatic stress disorder, cognitive disorders associated with dementia, AIDS dementia, Alzheimer's, Parkinson's, Huntington's disease, spasticity, myoclonus, muscle spasm, tinnitus and hearing impairment and loss are of particular importance.
Particular cognitive disorders are dementia, delirium, amnestic disorders and cognitive impartment including age-related cognitive decline.
Particular anxiety disorders are generalized anxiety disorder, obsessive-compulsive disorder and panic attack.
Particular schizophrenia or psychosis pathologies are paranoid, disorganized, catatonic or undifferentiated schizophrenia and substance-induced psychotic disorder.
Particular neurologic disorders that can be treated with the compounds of the formula (I) include in particular a cognitive disorder such as dementia, cognitive impairment, attention deficit hyperactivity disorder.
Particular psychiatric disorders that can be treated with the compounds of the formula (I) include in particular an anxiety disorder, a mood disorder such as depression or a bipolar disorder, schizophrenia, a psychotic disorder.
Within the context of the treatment, the use according to the invention of the compounds of the formula (I) involves a method. In this method, an effective quantity of one or more compounds or the formula (I), as a rule formulated in accordance with pharmaceutical and veterinary practice, is administered to the individual to be treated, preferably a mammal, in particular a human being. Whether such a treatment is indicated, and in which form it is to take place, depends on the individual case and is subject to medical assessment (diagnosis) which takes into consideration signs, symptoms and/or malfunctions which are present, the risks of developing particular signs, symptoms and/or malfunctions, and other factors.
As a rule, the treatment is effected by means of single or repeated daily administration, where appropriate together, or alternating, with other drugs or drug-containing preparations.
The invention also relates to the manufacture of pharmaceutical compositions for treating an individual, preferably a mammal, in particular a human being. Thus, the compounds of the formula (I) are customarily administered in the form of pharmaceutical compositions which comprise an inert carrier (e.g. a pharmaceutically acceptable excipient) together with at least one compound according to the invention and, where appropriate, other drugs. These compositions can, for example, be administered orally, rectally, transdermalty, subcutaneously, intravenously, intramuscularly or intranasally.
Examples of suitable pharmaceutical formulations are solid medicinal forms, such as powders, granules, tablets, in particular film tablets, lozenges, sachets, cachets, sugarcoated tablets, capsules, such as hard gelatin capsules and soft gelatin capsules, suppositories or vaginal medicinal forms, semisolid medicinal forms, such as ointments, creams, hydrogels, pastes or plasters, and also liquid medicinal forms, such as solutions, emulsions, in particular oil-in-water emulsions, suspensions, for example lotions, injection preparations and infusion preparations, and eyedrops and eardrops. Implanted release devices can also be used for administering inhibitors according to the invention. In addition, it is also possible to use liposomes or microspheres.
When producing the compositions, the compounds according to the invention are optionally mixed or diluted with one or more carriers (excipients). Carriers (excipients) can be solid, semisolid or liquid materials which serve as vehicles, carriers or medium for the active compound.
Suitable carriers (excipients) are listed in the specialist medicinal monographs. In addition, the formulations can comprise pharmaceutically acceptable auxiliary substances, such as wetting agents; emulsifying and suspending agents; preservatives; antioxidants; antiirritants; chelating agents; coating auxiliaries; emulsion stabilizers; film formers; gel formers; odor masking agents; taste corrigents; resin; hydrocolloids; solvents; solubilizers; neutralizing agents; diffusion accelerators; pigments; quaternary ammonium compounds; refatting and overfatting agents; raw materials for ointments, creams or oils; silicone derivatives; spreading auxiliaries; stabilizers; sterilants; suppository bases; tablet auxiliaries, such as binders, fillers, glidants, disintegrants or coatings; propellants; drying agents; opacifiers; thickeners; waxes; plasticizers and white mineral oils. A formulation in this regard is based on specialist knowledge as described, for example, in Fiedler, H. P., Lexikon der Hilfsstoffe für Pharmazie, Kosmetik and angrenzende Gebiete [Encyclopedia of auxiliary substances for pharmacy, cosmetics and related fields], 4 th edition, Aulendorf: ECV-Editio-Cantor-Verlag, 1996.
The compounds of formula (I) may also be suitable for combination with other therapeutic agents.
Thus, the present invention also provides:
i) a combination comprising a compound of formula (I) with one or more further therapeutic agents;

ii) a pharmaceutical composition comprising a combination product as defined in i) above and at least one carrier, diluent or excipient;

iii) the use of a combination as defined in i) above in the manufacture of a medicament for treating or preventing a disorder, disease or condition as defined herein;

iv) a combination as defined in i) above for use in treating or preventing a disorder, disease or condition as defined herein;

v) a kit-of-parts for use in the treatment of a disorder, disease or condition as defined herein, comprising a first dosage form comprising a compound of formula (I) and one or more further dosage forms each comprising one or more further therapeutic agents for simultaneous therapeutic administration,

vi) a combination as defined in i) above for use in therapy;

vii) a method of treatment or prevention of a disorder, disease or condition as defined herein comprising administering an effective amount of a combination as defined in i) above;

viii) a combination as defined in i) above for treating or preventing a disorder, disease or condition as defined herein.

The combination therapies of the invention may be administered adjunctively. By adjunctive administration is meant the coterminous or overlapping administration of each of the components in the form of separate pharmaceutical compositions or devices. This regime of therapeutic administration of two or more therapeutic agents is referred to generally by those skilled in the art and herein as adjunctive therapeutic administration; it is also known as add-on therapeutic administration. Any and all treatment regimes in which a patient receives separate but coterminous or overlapping therapeutic administration of the compounds of formula (I) and at least one further therapeutic agent are within the scope of the current invention. In one embodiment of adjunctive therapeutic administration as described herein, a patient is typically stabilised on a therapeutic administration of one or more of the components for a period of time and then receives administration of another component.
The combination therapies of the invention may also be administered simultaneously. By simultaneous administration is meant a treatment regime wherein the individual components are administered together, either in the form of a single pharmaceutical composition or device comprising or containing both components, or as separate compositions or devices, each comprising one of the components, administered simultaneously. Such combinations of the separate individual components for simultaneous combination may be provided in the form of a kit-of-parts.
In a further aspect, the invention provides a method of treatment of a psychotic disorder by adjunctive therapeutic administration of compounds of formula (I) to a patient receiving therapeutic administration of at least one antipsychotic agent. In a further aspect, the invention provides the use of compounds of formula (I) in the manufacture of a medicament for adjunctive therapeutic administration for the treatment of a psychotic disorder in a patient receiving therapeutic administration of at least one antipsychotic agent. The invention further provides compounds of formula (I) for use for adjunctive therapeutic administration for the treatment of a psychotic disorder in a patient receiving therapeutic administration of at least one antipsychotic agent.
In a further aspect, the invention provides a method of treatment of a psychotic disorder by adjunctive therapeutic administration of at least one antipsychotic agent to a patient receiving therapeutic administration of compounds of formula (I). In a further aspect, the invention provides the use of at least one antipsychotic agent in the manufacture of a medicament for adjunctive therapeutic administration for the treatment of a psychotic disorder in a patient receiving therapeutic administration of compounds of formula (I). The invention further provides at least one antipsychotic agent for adjunctive therapeutic administration for the treatment of a psychotic disorder in a patient receiving therapeutic administration of compounds of formula (I).
In a further aspect, the invention provides a method of treatment of a psychotic disorder by simultaneous therapeutic administration of compounds of formula (I) in combination with at least one antipsychotic agent. The invention further provides the use of a combination of compounds of formula (I) and at least one antipsychotic agent in the manufacture of a medicament for simultaneous therapeutic administration in the treatment of a psychotic disorder. The invention further provides a combination of compounds of formula (I) and at least one antipsychotic agent for simultaneous therapeutic administration in the treatment of a psychotic disorder. The invention further provides the use of compounds of formula (I) in the manufacture of a medicament for simultaneous therapeutic administration with at least one antipsychotic agent in the treatment of a psychotic disorder. The invention further provides compounds of formula (I) for use for simultaneous therapeutic administration with at least one antipsychotic agent in the treatment of a psychotic disorder. The invention further provides the use of at least one antipsychotic agent in the manufacture of a medicament for simultaneous therapeutic administration with compounds of formula (I) in the treatment of a psychotic disorder. The invention further provides at least one antipsychotic agent for simultaneous therapeutic administration with compounds of formula (I) in the treatment of a psychotic disorder.
In further aspects, the invention provides a method of treatment of a psychotic disorder by simultaneous therapeutic administration of a pharmaceutical composition comprising compounds of formula (I) and at least one mood stabilising or antimanic agent, a pharmaceutical composition comprising compounds of formula (I) and at least one mood stabilising or antimanic agent, the use of a pharmaceutical composition comprising compounds of formula (I) and at least one mood stabilising or antimanic agent in the manufacture of a medicament for the treatment of a psychotic disorder, and a pharmaceutical composition comprising compounds of formula (I) and at least one mood stabilising or antimanic agent for use in the treatment of a psychotic disorder.
Antipsychotic agents include both typical and atypical antipsychotic drugs. Examples of antipsychotic drugs that are useful in the present invention include, but are not limited to: butyrophenones, such as haloperidol, pimozide, and droperidol; phenothiazines, such as chlorpromazine, thioridazine, mesoridazine, trifluoperazine, perphenazine, fluphenazine, thiflupromazine, prochlorperazine, and acetophenazine; thioxanthenes, such as thiothixene and chlorprothixene; thienobenzodiazepines; dibenzodiazepines; benzisoxazoles; dibenzothiazepines; imidazolidinones; benziso-thiazolyl-piperazines; triazine such as lamotrigine; dibenzoxazepines, such as loxapine; dihydroindolones, such as molindone; aripiprazole; and derivatives thereof that have antipsychotic activity.
Examples of tradenames and suppliers of selected antipsychotic drugs are as follows: clozapine (available under the tradename CLOZARIL®, from Mylan, Zenith Goldline, UDL, Novartis); olanzapine (available under the tradename ZYPREX®, from Lilly); ziprasidone available under the tradename GEODON®, from Pfizer); risperidone (available under the tradename RISPERDAL®, from Janssen); quetiapine fumarate (available under the tradename SEROQUEL®, from AstraZeneca); haloperidol (available under the tradename HALDOL®, from Ortho-McNeil); chlorpromazine (available under the tradename THORAZINE®, from SmithKline Beecham (GSK)); fluphenazine (available under the tradename PROLIXIN®, from Apothecon, Copley, Schering, Teva, and American Pharmaceutical Partners, Pasadena); thiothixene (available under the tradename NAVANE®, from Pfizer); trifluoperazine (10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine dihydrochloride, available under the tradename STELAZINE®, from Smith Klein Beckman); perphenazine (available under the tradename TRILAFON®; from Schering); thioridazine (available under the tradename MELLARIL®; from Novartis, Roxane, HiTech, Teva, and Alpharma); molindone (available under the tradename MOBAN®, from Endo); and loxapine (available under the tradename LOXITANE(D; from Watson). Furthermore, benperidol (Glianimon®), perazine (Taxilan®) or melperone (Eunerpan®) may be used. Other antipsychotic drugs include promazine (available under the tradename SPARINE®), triflurpromazine (available under the tradename VESPRI N®), chlorprothixene (available under the tradename TARACTAN®), droperidol (available under the tradename INAPSINE®), acetophenazine (available under the tradename TINDAL®), prochlorperazine (available under the tradename COMPAZINE®), methotrimeprazine (available under the tradename NOZINAN®), pipotiazine (available under the tradename PIPOTRIL®), ziprasidone, and hoperidone.
In a further aspect, the invention provides a method of treatment of a neurodegenerative disorder such as Alzheimer Disease by adjunctive therapeutic administration of compounds of formula (I) to a patient receiving therapeutic administration of at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease. In a further aspect, the invention provides the use of compounds of formula (I) in the manufacture of a medicament for adjunctive therapeutic administration for the treatment of a neurodegenerative disorder such as Alzheimer Disease in a patient receiving therapeutic administration of at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease. The invention further provides compounds of formula (I) for use for adjunctive therapeutic administration for the treatment of a neurodegenerative disorder such as Alzheimer Disease in a patient receiving therapeutic administration of at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease.
In a further aspect, the invention provides a method of treatment of a neurodegenerative disorder such as Alzheimer Disease by adjunctive therapeutic administration of at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease to a patient receiving therapeutic administration of compounds of formula (I). In a further aspect, the invention provides the use of at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease in the manufacture of a medicament for adjunctive therapeutic administration for the treatment of a neurodegenerative disorder such as Alzheimer Disease in a patient receiving therapeutic administration of compounds of formula (I). The invention further provides at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease for adjunctive therapeutic administration for the treatment of a neurodegenerative disorder such as Alzheimer Disease in a patient receiving therapeutic administration of compounds of formula (I).
In a further aspect, the invention provides a method of treatment of a neurodegenerative disorder such as Alzheimer Disease by simultaneous therapeutic administration of compounds of formula (I) in combination with at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease. The invention further provides the use of a combination of compounds of formula (I) and at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease in the manufacture of a medicament for simultaneous therapeutic administration in the treatment of a neurodegenerative disorder such as Alzheimer Disease. The invention further provides a combination of compounds of formula (I) and at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease for simultaneous therapeutic administration in the treatment of a neurodegenerative disorder such as Alzheimer Disease. The invention further provides the use of compounds of formula (I) in the manufacture of a medicament for simultaneous therapeutic administration with at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease in the treatment of a neurodegenerative disorder such as Alzheimer Disease. The invention further provides compounds of formula (I) for use for simultaneous therapeutic administration with at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease in the treatment of a neurodegenerative disorder such as Alzheimer Disease. The invention further provides the use of at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease in the manufacture of a medicament for simultaneous therapeutic administration with compounds of formula (I) in the treatment of a neurodegenerative disorder such as Alzheimer Disease. The invention further provides at least one agent suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease for simultaneous therapeutic administration with compounds of formula (I) in the treatment of a neurodegenerative disorder such as Alzheimer Disease.
Examples of agents suitable for the treatment of a neurodegenerative disorder such as Alzheimer Disease that are useful in the present invention include, but are not limited to: cholinesterase inhibitors, agents targeting nicotinic or muscarinic acethylcholine receptors, NMDA receptors, amyloid formation, mitochondrial dysfunctions, disease associated calpain activity, neuroinflamation, tumor necrosis factor receptors, NF-kappaB, peroxisome proliferator activator receptor gamma, Apolipoprotein E variant 4 (ApoE4), diseaseassociated increase of the HPA axis, epileptic discharges, vascular dysfunction, vascular risk factors, and oxidative stress.
Suitable cholinesterase inhibitors which may be used in combination with the compounds of the inventions include for example tacrine, donepezil, galantamine and rivastigmine.
Suitable NMDA receptors targeting agents which may be used in combination with the compounds of the inventions include for example memantine.
Suitable agents affecting increased HPA axis activity which may be used in combination with the compounds of the inventions include for example CRF1 antagonists or V1b antagonists.
In a further aspect therefore, the invention provides a method of treatment of pain by adjunctive therapeutic administration of compounds of formula (I) to a patient receiving therapeutic administration of at least one agent suitable for the treatment of pain. In a further aspect, the invention provides the use of compounds of formula (I) in the manufacture of a medicament for adjunctive therapeutic administration for the treatment of pain in a patient receiving therapeutic administration of at least one agent suitable for the treatment of pain. The invention further provides compounds of formula (I) for use for adjunctive therapeutic administration for the treatment of pain in a patient receiving therapeutic administration of at least one agent suitable for the treatment of pain.
In a further aspect, the invention provides a method of treatment of pain by adjunctive therapeutic administration of at least one agent suitable for the treatment of pain to a patient receiving therapeutic administration of compounds of formula (I). In a further aspect, the invention provides the use of at least one agent suitable for the treatment of pain in the manufacture of a medicament for adjunctive therapeutic administration for the treatment of pain in a patient receiving therapeutic administration of compounds of formula (I). The invention further provides at least one agent suitable for the treatment of pain for adjunctive therapeutic administration for the treatment of pain in a patient receiving therapeutic administration of compounds of formula (I).
In a further aspect, the invention provides a method of treatment of pain by simultaneous therapeutic administration of compounds of formula (I) in combination with at least one agent suitable for the treatment of pain. The invention further provides the use of a combination of compounds of formula (I) and at least one agent suitable for the treatment of pain in the manufacture of a medicament for simultaneous therapeutic administration in the treatment of pain. The invention further provides a combination of compounds of formula (I) and at least one agent suitable for the treatment of pain for simultaneous therapeutic administration in the treatment of pain. The invention further provides the use of compounds of formula (I) in the manufacture of a medicament for simultaneous therapeutic administration with at least one agent suitable for the treatment of pain in the treatment of pain. The invention further provides compounds of formula (I) for use for simultaneous therapeutic administration with at least one agent suitable for the treatment of pain in the treatment of pain. The invention further provides the use of at least one agent suitable for the treatment of pain in the manufacture of a medicament for simultaneous therapeutic administration with compounds of formula (I) in the treatment of pain. The invention further provides at least one agent suitable for the treatment of pain for simultaneous therapeutic administration with compounds of formula (I) in the treatment of pain.
Examples of agents suitable for the treatment of pain that are useful in the present invention include, but are not limited to: NSAIDs (Nonsteroidal Antiinflammatory Drugs), anti-convulsant drugs such as carbamazepine and gabapentin, sodium channel blockers, anti-depressant drugs, cannabinoids and local anaesthetics.
Suitable agents used in combination with the compounds of the inventions include for example celecoxib, etoricoxib, lumiracoxib, paracetamol, tramadol, methadone, venlafaxine, imipramine, duloxetine, bupropion, gabapentin, pregabalin, lamotrigine, fentanyl, parecoxib, nefopam, remifentanil, pethidine, diclofenac, rofecoxib, nalbuphine, sufentanil, pethidine, diamorphine and butorphanol.
It will be appreciated by those skilled in the art that the compounds according to the invention may advantageously be used in conjunction with one or more other therapeutic agents, for instance, antidepressant agents such as 5HT3 antagonists, serotonin agonists, NK-1 antagonists, selective serotonin reuptake inhibitors (SSRI), noradrenaline re-uptake inhibitors (SNRI), tricyclic antidepressants, dopaminergic antidepressants, H3 antagonists, 5HT1A antagonists, 5HT1 B antagonists, 5HT1 D antagonists, D1 agonists, M1 agonists and/or anticonvulsant agents, as well as cognitive enhancers.
Suitable 5HT3 antagonists which may be used in combination of the compounds of the inventions include for example ondansetron, granisetron, metoclopramide.
Suitable serotonin agonists which may be used in combination with the compounds of the invention include sumatriptan, rauwolscine, yohimbine, metoclopramide.
Suitable SSRIs which may be used in combination with the compounds of the invention include fluoxetine, citalopram, femoxetine, fluvoxamine, paroxetine, indalpine, sertraline, zimeldine.
Suitable SNRIs which may be used in combination with the compounds of the invention include venlafaxine and reboxetine.
Suitable tricyclic antidepressants which may be used in combination with a compound of the invention include imipramine, amitriptiline, chlomipramine and nortriptiline.
Suitable dopaminergic antidepressants which may be used in combination with a compound of the invention include bupropion and amineptine.
Suitable anticonvulsant agents which may be used in combination of the compounds of the invention include for example divalproex, carbamazepine and diazepam.
The following examples serve to explain the invention without limiting it.
The compounds were characterized by mass spectrometry, generally recorded via HPLC-MS in a fast gradient on C18-material (electrospray-ionisation (ESI) mode).
PREPARATION EXAMPLES
All final compounds have cis configuration at the tetrahydronaphthalen core if not otherwise noted.
Example 1
[7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3,4-dichloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester
1.1 1-(3,4-Dichlorobenzyl)-7-methoxy-3,4-dihydronaphthalen-2(1H)-one









15 g (85 mmol) of 7-methoxy-3,4-dihydronaphthalen-2(1H)-one were dissolved in 200 ml of dry MeOH under nitrogen. Then 6.66 g (94 mmol) of pyrrolidine were added dropwise and slowly and the colour changes. The mixture is stirred for one h. The solvent was reduced under vacuo and the residue was dissolved in MeCN. At 5° C. 22.5 g (94 mmol) 4-(bromomethyl)-1,2-dichlorobenzene dissolved in MeCN were added and the mixture was stirred over night at RT. The solvent was reduced under vacuo and the residue was mixed with MeOH/CH 2 Cl 2 /H 2 O 1:1:1 (50 ml, 50 ml, 50 ml) and 10 ml of glacial acid were added. The mixture was stirred over night. Work-up: The reaction mixture was put on ice water and extracted 3× with CH 2 Cl 2 . The combined organic layers were washed 1× with NaHCO 3 solution and 1× with saturated NaCl solution. The organic phase was dried on MgSO 4 and the solvent was evaporated. The residue (31.5 g) was purified by flash-chromatography on silica gel with heptane/EtOAc 2:1. 24.1 g (71.7 mmol, 84%) of the product were obtained.
ESI-MS [M+H + ]=335.1 Calculated for C 18 H 16 Cl 2 O 2 =334.05.
1.2 1-(3,4-Dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride









To 1-(3,4-dichlorobenzyl)-7-methoxy-3,4-dihydronaphthalen-2(1H)-one 5.2 g (15.5 mmol) in MeOH reactant ammonium acetate (12.0 g, 155 mmol) and sodium cyanoborohydride (1.46 g, 23.3 mmol) were added under nitrogen. The mixture was stirred for 4 d at RT. The solvent was reduced under vacuo and extracted with EtOAc after addition of water. The organic layer was washed with NaCl, dried on MgSO 4 and the solvent was removed. The residue was dissolved in iPrOH and HCl in iPrOH (6N) was added. After crystallization over night the HCl-salt was separated from the mother liquor and transferred to the free base with NaOH (1N). An oil was obtained that after treatment with HCl gave the cis product (1.95 g, 5.80 mmol, 37.4%) after crystallization. The mother liquor contained a cis/trans mixture of the product.
ESI-MS [M+H + ]=336.2 Calculated for C 18 H 19 Cl 2 NO=336.26.
1.3 Ethyl 1-(3,4-dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate
To 1-(3,4-dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1.95 g, 5.80 mmol) in pyridine 10 ml) the ethylchloroformate (1.00 g, 9.28 mmol) was added slowly under nitrogen. The mixture was stirred over night at RT. The solvent was reduced under vacuo and extracted with CH 2 Cl 2 after addition of HCl (1N). The organic layer was washed with HCl (1N), NaHCO 3 solution, and NaCl solution, then dried on MgSO 4 and the solvent was removed. The product was obtained as an orange oil that precipitates after a few hours (2.10 g, 5.14 mmol, 89%).









ESI-MS [M+H + ]=408.2 Calculated for C 21 H 23 ClN 2 O 3 =407.11.
1.4 Ethyl 1-(3,4-dichlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate









Ethyl 1-(3,4-dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (2.1 g, 5.14 mmol) was dissolved in CH 2 Cl 2 (50 ml) and BBr 3 (3.87 g, 15.4 mmol) was added at −10° C. The reaction mixture was slowly warmed to RT and stirred for 2 h. The reaction mixture was added to ice water and extracted with CH 2 Cl 2 . The organic layer was washed with NaHCO 3 solution and NaCl solution, then dried on MgSO 4 and the solvent was removed. The product was obtained as a brown oil (2.05 g, 5.14 mmol, 100%).
ESI-MS [M+H + ]=394.1 Calculated for C 20 H 21 Cl 2 NO 3 =393.09.
1.5 7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3,4-dichloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









NaH (55% in paraffin, 34.5 mmol) was suspended in DMA (80 ml) and ethyl 1-(3,4-dichlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (6.80 g, 17.3 mmol) dissolved in DMA (40 ml) was added. The mixture was stirred for another h. Then the bromide was added in portions and the mixture was stirred for 3 d at RT. The reaction mixture was added to half concentrated NaCl and extracted with EtOAc. The organic layer was washed with H 2 O, NaCl solution, then dried on MgSO 4 and the solvent was removed. Some DMA was removed on an oil pump. The residue was purified by flash chromatography using silica gel and CH 2 Cl 2 /MeOH 98:2. The product was obtained as an yellow oil (9.27 g, 17.3 mmol, 100%) that becomes solid after a few hours.
ESI-MS [M+H + ]=481.1 Calculated for C 27 H 34 Cl 2 N 2 O 5 =536.18
Example 2
Ethyl 1-(3,4-dichlorobenzyl)-7-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate
2.1 Ethyl 7-(2-aminoethoxy)-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate hydrochloride









[7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3,4-dichloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester (9.27 g, 17.3 mmol) example 1 was dissolved in CH 2 Cl 2 (200 ml) and HCl in iPrOH (6N) was added. The reaction was stirred at RT over night after which a solid precipitates. To the reaction mixture diethyl ether was added and the precipitating HCl salt was separated by filtration to give the final product as a solid (5.85 g, 12.3 mmol, 72%).
ESI-MS [M+H + ]=437.1 Calculated for C 22 H 26 Cl 2 N 2 O 3 =436.13
2.2 Ethyl 1-(3,4-dichlorobenzyl)-7-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate









Ethyl 7-(2-aminoethoxy)-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate hydrochloride (100 mg, 0.229 mmol) and DMAP (27.9 mg, 0.229 mmol) were dissolved in CH 2 Cl 2 (15 ml) and 1-methyl-1H-imidazole-4-sulfonyl chloride (41.3 mg, 0.229 mmol) dissolved in CH 2 Cl 2 (15 ml) was added. The reaction mixture was stirred over night at RT. After addition of H 2 O the phases were separated and the aqueous phase was extracted with CH 2 Cl 2 . The organic layer was washed with HCl (1N), NaHCO 3 solution and NaCl solution, then dried on MgSO 4 and the solvent was removed. To the residue EtOAc/diethylether (1:1) was added, stirred, and the precipitate was separated by filtration to obtain a brown solid of product (100 mg).
ESI-MS [M+H + ]=581.5 Calculated for C 26 H 30 Cl 2 N 4 O 5 S=580.13
Example 3
N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









Ethyl 1-(3,4-dichlorobenzyl)-7-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1.00 g, 1.72 mmol) example 2 was refluxed in 25 g of EtOH/20% KOH for 2 h. To the reaction mixture half concentrated NaCl solution was added and the mixture was extracted with ethyl acetate. The organic layers were combined and washed with NaCl solution, then dried on MgSO 4 and the solvent was removed. A significant amount was found to be bound on MgSO 4 and so additional separation/extraction with H 2 O/CH 2 Cl 2 and drying on Na 2 SO 4 resulted in a yellow oil (830 mg). This residue was dissolved in little MeOH, HCl (1N) was added, and the final product (650 mg, 1.19 mmol, 69%) was separated by filtration.
ESI-MS [M+H + ]=509.1 Calculated for C 23 H 26 Cl 2 N 4 O 3 S=508.11
Example 4
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrodrochloride was prepared analogously to example 3 using 1-methyl-1H-pyrazole-4-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=509.1 Calculated for C 23 H 26 Cl 2 N 4 O 3 S=508.11
Example 5
Pyridine-3-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Pyridine-3-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared analogously to example 3 using pyridyl-3-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=506.1 Calculated for C 24 H 25 Cl 2 N 3 O 3 S=505
Example 6









N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)propane-1-sulfonamide (example 8) (66.0 mg, 0.140 mmol), paraformaldehyde (7.63 mg, 0.254 mmol), and formic acid (21.6 mg, 0.469 mmol) were dissolved in ethanol (5 ml) and refluxed for 4 h. The solvent was reduced and to the residue NaOH (1N) was added. After extraction with CH 2 Cl 2 the organic layers were washed with water and saturated NaCl solution, dried with Na 2 SO 4 , filtered, and the solvent was removed. The residue was purified by column chromatography (CH 2 Cl 2 /MeOH 97:7->95:5). The final product (15.0 mg, 0.028 mmol, 20%) was obtained as a brown, solid HCl salt from isopropanol treated with HCl in isopropanol (6N).
ESI-MS [M+H + ]=499.1 Calculated for C 24 H 32 Cl 2 N 2 O 3 S=498
Example 7
1-(3,4-Dichloro-benzyl)-7-[2-(propane-1-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









{1-(3,4-Dichloro-benzyl)-7-[2-(propane-1-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester was prepared analogously to example 3 using propane-1-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=543.2 Calculated for C 25 H 32 Cl 2 N 2 O 5 S=542
Example 8
Propane-1-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Propane-1-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared analogously to example 3 using propane-1-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride. ESI-MS [M+H + ]=471.1 Calculated for C 22 H 28 Cl 2 N 2 O 3 S=470
Example 9
{1-(3,4-Dichloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









{1-(3,4-Dichloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester was prepared analogously to example example 3 using 1-methyl-1H-pyrazole-4-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=581.2 Calculated for C 26 H 30 Cl 2 N 4 O 5 S=580
Example 10
{1-(3,4-Dichloro-benzyl)-7-[2-(pyridine-3-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









{1-(3,4-Dichloro-benzyl)-7-[2-(pyridine-3-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester was prepared analogously to example 3 using pyridine-3-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=578.2 Calculated for C 27 H 29 Cl 2 N 3 O 5 S=577
Example 11
N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-N-methylpropane-1-sulfonamide hydrochloride
11.1 N-(1-(3,4-Dichlorobenzyl)-7-(2-(propylsulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl)-2,2,2-trifluoroacetamide









N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)propane-1-sulfonamide (example 3, 150 mg, 0.318 mmol) and triethylamine (32.2 mg, 0.318 mmol) were dissolved in THF (10 ml) and trifluoro acetic anhydride (66.8 mg, 0.318 mmol) was added. The mixture was stirred at RT for 48 h. Ethyl acetate was added and the mixture was extracted with water and then washed with a NaHCO 3 solution and a saturated NaCl solution. After drying with MgSO 4 and removal of the solvent the residue was purified by chromatography on silica gel using CH 2 Cl 2 /MeOH 98:2 to give the final product as a colourless oil that becomes solid after a while (80.0 mg, 0.141 mmol, 44%).
11.2 N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-N-methylpropane-1-sulfonamide hydrochloride









NaH (3.38 mg, 0.078 mmol, 55% in oil) was suspended in DMA (5 ml) and N-(1-(3,4-dichlorobenzyl)-7-(2-(propylsulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl)-2,2,2-trifluoroacetamide (40 mg, 0.07 mmol) dissolved in DMA (4 ml) was added dropwise. After stirring for 1 h iodomethane (10.5 mg, 0.074 mmol) dissolved in DMA (1 ml) was added. After stirring for another 14 h the reaction mixture was added to a halfconcentrated solution of NaCl. Extraction with ethyl acetate, washing of the organic layers with water and saturated NaCl solution followed by drying with Na 2 SO 4 gave a residue that was washed with diisopropyl ether. Cleavage of the amide bond was achieved by stirring the residue with concentrated NaOH in water and subsequent extraction with ethyl acetate. The organic layer was dried with MgSO 4 and evaporated. The residue was purified by preparative HPLC (RP-18, acetonitrile/water, 0.01% TFA). After transferring the product into the HCl salt a yellow solid (11.0 mg, 0.021 mmol, 30%) was obtained.
ESI-MS [M+H + ]=485.2 Calculated for C 23 H 30 Cl 2 N 2 O 3 S=484
Example 12
[1-(3,4-Dichloro-benzyl)-7-(2-methanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









[1-(3,4-Dichloro-benzyl)-7-(2-methanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester was prepared analogously to example 3 using methyl sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=515.1 Calculated for C 23 H 28 Cl 2 N 2 O 5 S=514
Example 13
[7-(2-Benzenesulfonylamino-ethoxy)-1-(3,4-dichloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









[7-(2-Benzenesulfonylamino-ethoxy)-1-(3,4-dichloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester was prepared analogously to example 3 using phenyl sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=577.2 Calculated for C 28 H 30 Cl 2 N 2 O 5 S=576
Example 14
{1-(3,4-Dichloro-benzyl)-7-[2-(thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









{1-(3,4-Dichloro-benzyl)-7-[2-(thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester was prepared analogously to example 3 using phenyl sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=583.1 Calculated for C 26 H 28 Cl 2 N 2 O 5 S 2 =582
Example 15
N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-methanesulfonamide hydrochloride









N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-methanesulfonamide was prepared analogously to example 3 using methyl sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=443.1 Calculated for C 20 H 24 Cl 2 N 2 O 3 S=442
Example 16
N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-benzenesulfonamide hydrochloride









N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-benzenesulfonamide was prepared analogously to example 3 using phenyl sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=505.1 Calculated for C 25 H 26 Cl 2 N 2 O 3 S=504
Example 17
Thiophene-2-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Thiophene-2-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide was prepared analogously to example 3 using thiophene sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=511.1 Calculated for C 23 H 24 Cl 2 N 2 O 3 S 2 =510
Example 18
N-{1-(3,4-Dichloro-benzyl)-7-[2-(1-methyl-1 imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-2,2,2-trifluoro-acetamide









N-{1-(3,4-Dichloro-benzyl)-7-[2-(1-methyl-1H-imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-2,2,2-trifluoro-acetamide was prepared analogously to example 11 using the product of example 3 in place of example 8.
ESI-MS [M+H + ]=605.1 Calculated for C 25 H 25 Cl 2 F 3 N 4 O 4 S=604
Example 19
Pyrrolidine-3-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Pyrrolidine-3-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride was prepared analogously to example 3 using benzyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate (synthesis described in WO2008075070) in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=498.2 Calculated for C 23 H 29 Cl 2 N 3 O 3 S=497
Example 20
1-Methyl-1H-imidazole-4-sulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-formylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide









Ethyl 1-(3,4-dichlorobenzyl)-7-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (example 3, 60.0 mg, 0.103 mmol) was dissolved in THF (5 ml) and LiAlH 4 (7.83 mg, 0.206 mmol) was added at RT. The residue was added to 2N NaOH and extracted with dichloromethane. The organic layer was washed with saturated NaHCO 3 solution and then with saturated NaCl solution, dried and evaporated. The product was precipitated as an HCl salt from 6N HCl in isopropanol and isopropylether to obtain the product as a white salt (36 mg, 61%).
ESI-MS [M+H + ]=537.1 Calculated for C 24 H 26 Cl 2 N 4 O 4 S=536
Example 21
1-(3,4-Dichloro-benzyl)-7-[2-(4-methyl-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









1-(3,4-Dichloro-benzyl)-7-[2-(4-methyl-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester was prepared analogously to example 3 using 4-methylthiophene-2-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=597.1 Calculated for C 27 H 30 Cl 2 N 2 O 5 S 2 =596
Example 22
{1-(3,4-Dichloro-benzyl)-7-[2-(3-fluoro-propane-1-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









{1-(3,4-Dichloro-benzyl)-7-[2-(3-fluoro-propane-1-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester was prepared analogously to example 3 using 3-fluoropropane-1-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=561.2 Calculated for C 25 H 31 Cl 2 FN 2 O 5 S=560
Example 23
1-Methyl-1H-imidazole-4-sulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-ethylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide









Ethyl 1-(3,4-dichlorobenzyl)-7-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (example 3, 60.0 mg, 0.103 mmol) was dissolved in dichloromethane (5 ml) and acetaldehyde (5.45 mg, 0.124 mmol μl) and molsieve 3 {acute over (Å)} were added and the mixture was stirred for 3 h. Acetic acid (7.07 mg, 0.118 mmol) was added and the mixture was stirred for another 3 h. MeOH (5 ml) and sodium cyanoborohydride (14.8 mg, 0.236 mmol) were added and it was stirred for another 14 h. Water was added and it was extracted with dichloromethane. The organic layer was washed with saturated NaHCO 3 solution, washed and evaporated. The residue was purified by column chromatography using SiO 2 and CH 2 Cl 2 /MeOH 95:5->90:10. The product was precipitated as an HCl salt from 6N HCl in isopropanol and isopropylether to obtain the product as a white salt (17 mg, 25%).
ESI-MS [M+H + ]=537.2 Calculated for C 25 H 30 Cl 2 N 4 O 3 S=536
Example 24
4-Methyl-thiophene-2-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









4-Methyl-thiophene-2-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared analogously to example 3 using 4-methylthiophene-2-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=525.1 Calculated for C 24 H 26 Cl 2 N 2 O 3 S 2 =524
Example 25
N′-(2-{[7-amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-N,N-dimethylsulfuric diamide hydrochloride









N′-(2-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-N,N-dimethylsulfuric diamide hydrochloride was prepared analogously to example 3 using dimethylsulfamoyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=472.1 Calculated for C 21 H 27 Cl 2 N 3 O 3 S=471
Example 26
{1-(3,4-Dichloro-benzyl)-7-[2-(3,3,3-trifluoro-propane-1-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









{1-(3,4-Dichloro-benzyl)-7-[2-(3,3,3-trifluoro-propane-1-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester was prepared analogously to example 3 using dimethylsulfamoyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=597.1 Calculated for C 25 H 29 Cl 2 F 3 N 2 O 5 S=596
Example 27
1-Methyl-1H-imidazole-4-sulfonic acid {2-[7-amino-8-(4-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









1-Methyl-1H-imidazole-4-sulfonic acid {2-[7-amino-8-(4-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride was prepared analogously to example 3 using 1-methyl-1H-imidazole-4-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride and 4-(bromomethyl)-1-dichlorobenzene instead of 4-(bromomethyl)-1,2-dichlorobenzene.
ESI-MS [M+H + ]=475.1 Calculated for C 23 H 27 ClN 4 O 3 S=474
Example 28
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(4-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(4-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared analogously to example 3 using 1-methyl-1H-pyrazole-4-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride and 4-(bromomethyl)-1-dichlorobenzene instead of 4-(bromomethyl)-1,2-dichlorobenzene.
ESI-MS [M+H + ]=475.1 Calculated for C 23 H 27 ClN 4 O 3 S=474
Example 29
7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile trifluoroacetate
29.1 8-(3,4-Dichlorobenzyl)-7-[(ethoxycarbonyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate









Ethyl 1-(3,4-dichlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (700 mg, 1.775 mmol, cf. example 3d) and 1,1,1-trifluoro-N-phenyl-N-(trifluoromethylsulfonyl)methanesulfonamide (761 mg, 2.13 mmol) were dissolved in dichloromethane (30 mL). The reaction mixture was cooled to 0° C. and a solution of triethylamine (0.495 mL, 3.55 mmol) in dichloromethane (5 mL) was added dropwise. The reaction mixture was allowed to warm to room temperature and stirring was continued over night. The solvent was evaporated in vacuo and the crude product was purified by flash chromatography (dichloromethane, silica gel). Yield: 934 mg (100%).
ESI-MS [M+H + ]=526 Calculated for C 21 H 20 Cl 2 F 3 NO 5 S=525.
29.2 Ethyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









8-(3,4-Dichlorobenzyl)-7-[(ethoxycarbonyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (250 mg, 0.475 mmol), zinc cyanide (139 mg, 1.187 mmol) and tetrakistriphenyl palladium (82 mg, 0.071 mmol) in dimethylformamide (5 mL) were heated in the microwave at 120° C. (100 W) under stirring for 35 min. The solvent was evaporated in vacuo and the crude product was partitioned between ethyl acetate (40 mL) and water (30 mL). The aqueous layer was extracted with ethyl acetate one more time (20 mL) and the combined organic extracts were dried (Na 2 SO 4 ) and concentrated in vacuo. The crude product (460 mg) was purified by flash chromatography (dichloromethane to dichloromethane:methanol=100:1, silica gel). Yield: 109 mg (0.270 mmo, 57%, colorless solid). ESI-MS [M+H + ]=403 Calculated for C 21 H 20 Cl 2 N 2 O 2 =402.
29.3 7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile trifluoroacetate









Ethyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (50 mg, 0.124 mmol) was dissolved in 10% potassium hydroxide in ethanol (1.5 mL) and the reaction mixture was stirred at 80° C. for 2.5 h. The solvent was evaporated in vacuo. To the crude product brine (5 mL) and 2N hydrochloric acid were added until pH 7 was reached. The aqueous layer was extracted with dichloromethane three times. The combined organic extracts were dried (Na 2 SO 4 ) and concentrated in vacuo. The crude product (60 mg) was purified by preparative HPLC (xTerra prep MS C18 column, 19×150 mm, 5 μm; gradient: water, acetonitrile with 0.1% trifluoroacetic acid, flow: 20 mL/min). Yield: 6 mg (0.013 mmol, 11%).
ESI-MS [M+H + ]=331 Calculated for C 18 H 16 C 12 N 2 =330.
Example 30
7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride
30.1 7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-ol









1-(4-chlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (13.18 g, 43.7 mmol, prepared analogously to 1-(3,4-dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine cf. example 3) was dissolved in dichloromethane (200 mL). The solution was cooled to −10° C. and a 1 M solution of borontribromide in dichloromethane (131 mL, 131 mmol) was slowly added. The reaction mixture was allowed to warm to room temperature and stirring was continued for 2 h. The reaction mixture was poured on ice water and sodium hydroxide was added until pH 8 was reached. The aqueous layer was extracted with dichloromethane. The combined organic extracts were dried (Na 2 SO 4 ) and concentrated in vacuo. The crude product was used for the next step without further purification. Yield: 8.89 g (30.9 mmol, 71%, colorless solid).
ESI-MS [M+H + ]=288 Calculated for C 17 H 18 ClNO=287.
30.2 Tert-butyl [1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-ol (2.0 g, 6.95 mmol) was dissolved in dry tetrahydrofurane and di-tertiar butyl carbonate (1.517 g, 6.95 mmol) and triethylamine (2.91 mL, 20.85 mmol) were added. The reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated in vacuo. Water was added and the aqueous layer was extracted with dichloromethane. The combined organic extracts were dried (Na 2 SO 4 ) and concentrated in vacuo. The crude product was recrystallized from n-hexane. Yield: 2.2 g (5.67 mmol, 82%).
ESI-MS [M-isobutene+H + ]=332 Calculated for C 22 H 26 ClNO 3 =387.
30.3 7-[(Tert-butoxycarbonyl)amino]-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate









Tert-butyl [1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (850 mg, 2.191 mmol) and 1,1,1-trifluoro-N-phenyl-N-(trifluoromethylsulfonyl)methanesulfonamide (939 mg, 2.63 mmol) were dissolved in dichloromethane (45 mL). The pale yellow solution was cooled to 0° C. and a solution of triethylamine (0.611 mL, 4.38 mmol) in dichloromethane (5 mL) was added dropwise. The reaction mixture was allowed to warm to room temperature and stirring was continued over night. The solvent was evaporated in vacuo and the crude product was purified by flash chromatography (dichloromethane, silica gel). Yield: 1.03 g (1.981 mmol, 90%, colorless solid).
ESI-MS [M-isobutene+CH 3 CN+H + ]=505 Calculated for C 23 H 25 ClF 3 NO 5 S=519.
30.4 Tert-butyl [1-(4-chlorobenzyl)-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









DPPF (8.1 mg, 0.015 mmol) and Pd 2 dba 3 (3.35 mg, 0.00365 mmol) were suspended in dimethylformamide (0.4 mL) and after stirring at room temperature under an inert atmosphere of nitrogen for 20 min 7-[(tert-butoxycarbonyl)amino]-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (38 mg, 0.073 mmol) and zinc cyanide (12.87 mg, 0.110 mmol) were added. The reaction mixture was stirred at 90° C. for 1 h. The solvent was evaporated in vacuo. Water (10 mL) was added to the crude product and the aqueous layer was extracted with ethyl acetate (two times with 10 mL). The combined organic extracts were dried (Na 2 SO 4 ) and concentrated in vacuo. The crude product was purified by flash chromatography (dichloromethane, silica gel). Yield: 16 mg (0.040 mmol, 55%).
ESI-MS [M-isobutene+CH 3 CN+H + ]=382 Calculated for C 23 H 25 ClN 2 O 2 =396.
30.5 7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride









Tert-butyl [1-(4-chlorobenzyl)-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (15 mg, 0.038 mmol) was dissolved in dichloromethane (1.5 mL) and 5 M hydrochloric acid in isopropanol (0.3 mL) was added. The reaction mixture was stirred for 3 h at room temperature. The solvent and the excess hydrochloric acid were evaporated in vacuo. Yield: 11 mg (0.033 mmol, 87%, colorless solid).
ESI-MS [M+H + ]=297 Calculated for C 18 H 17 ClN 2 =296.
Example 31
N-[(7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]-3-fluoropropane-1-sulfonamide trifluoroacetate
31.1 Tert-butyl [7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









Tert-butyl [1-(4-chlorobenzyl)-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (52 mg, 0.131 mmol, cf. example 30d) were dissolved in methanol (5 mL). Raney nickel (about 30 mg) was added and the reaction mixture was stirred at room temperature for 4 h under an atmosphere of hydrogen. The catalyst was removed by filtration. The solvent was evaporated in vacuo. The crude product was used without further purification for the next step. Yield: 32 mg (0.087 mmol, 67%).
ESI-MS [M-isobutene+H + ]=311 Calculated for C 23 H 30 N 2 O 2 =366.
31.2 Tert-butyl [1-benzyl-7-({[(3-fluoropropyl)sulfonyl]amino}methyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









Tert-butyl [7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (32 mg, 0.87 mmol) was dissolved in dichloromethane (15 mL) and 4-dimethylaminopyridine (12 mg, 0.096 mmol) and 3-fluoropropane-1-sulfonyl chloride (14 mg, 0.087 mmol) were added. The reaction mixture was stirred at room temperature over night. The dichloromethane solution of the crude product was washed successively with 1N aqueous hydrochloric acid and aqueous NaHCO 3 solution, dried (Na 2 SO 4 ) and concentrated in vacuo. The crude product was purified by flash chromatography (dichloromethane, methanol, silica gel). Yield: 9.3 mg (0.019 mmol, 22%).
ESI-MS [M-isobutene+H + ]=435 Calculated for C 26 H 35 FN 2 O 4 S=490.
31.3 N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-3-fluoropropane-1-sulfonamide trifluoroacetate









Tert-butyl [1-benzyl-7-({[(3-fluoropropyl)sulfonyl]amino}methyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (9.3 mg, 0.019 mmol) was dissolved in dichloromethane (10 mL) and trifluoroacetic acid (excess) was added. The reaction mixture was stirred at room temperature for 4 h. The solvent was evaporated in vacuo and the crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 4 mg (0.0079 mmol, 42%).
ESI-MS [M+H + ]=391 Calculated for C 21 H 27 FN 2 O 2 S=390.
Example 32
Ethyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









Cf. Example 29b.
ESI-MS [M+H + ]=403 Calculated for C 21 H 20 Cl 2 N 2 O 2 =402.
Example 33
1-(3-chlorobenzyl)-7-[2-(1,1-dioxidoisothiazolidin-2-yl)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride









ESI-MS [M+H + ]=435 Calculated for C 22 H 27 ClN 2 O 3 S=434.
Example 34
tert-Butyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate
34.1 7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-ol









1-(3,4-Dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (10 g, 26.8 mmol, cf. example 3.2 were dissolved in dichloromethane (240 mL). The suspension was cooled to −10° C. and a 1 M solution of bortribromide in dichloromethane (80 mL, 80 mmol). The solution was allowed to warm to room temperature and stirring was continued for 3 h. The reaction mixture was poured on ice (1 L). The aqueous layer was made alkaline (pH 10) with 2N sodium hydroxide solution. The layers were separated. The aqueous layer was extracted with dichloromethane and the combined organic layers were washed with saturated NaHCO 3 solution and water. The organic layers were dried (Na 2 SO 4 ) and concentrated in vacuo. The crude product was used without further purification for the next step. Yield: 10.8 g
ESI-MS [M+H + ]=322 Calculated for C 17 H 17 Cl 2 NO=321.
34.2 tert-Butyl [1-(3,4-dichlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-ol (10.8 g) and triethylamine (14.01 mL, 101 mmol) were dissolved in dry tetrahydrofuran (200 mL). Di-tert-butyl carbonate (7.31 g, 33.5 mmol) was added in small portions at room temperature. The reaction mixture was stirred over night. The solvent was evaporated in vacuo. The residue was dissolved in ethyl acetate (300 mL) and washed with water (2×200 mL). The ethyl acetate solution of the crude product was dried (Na 2 SO 4 ). The solvent was evaporated in vacuo and the crude product was used for the next step without further purification. Yield: 12.2 g.
ESI-MS [M-isobutene+CH3CN+H + ]=407 Calculated for C 22 H 25 Cl 2 NO 3 =421.
34.3 7-[(tert-Butoxycarbonyl)amino]-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate









tert-Butyl [1-(3,4-dichlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (4.06 g, 9.66 mmol) and 1,1,1-trifluoro-N-phenyl-N-(trifluoromethylsulfonyl)methanesulfonamide (4.14 g, 11.59 mmol) were dissolved in dichloromethane (190 mL). The light brown solution was cooled to 0° C. and triethylamine (2.69 mL, 19.32 mmol) in dichloromethane (10 mL) was added dropwise. The reaction mixture was allowed to warm to room temperature and stirring was continued over night. The solvent was evaporated in vacuo and the crude product was purified by flash chromatography (dichloromethane, silica gel). Yield: 3.2 g (5.77 mmol, 60%).
34.4 tert-Butyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









Diphenylphosphinoferrocene (100 mg, 0.18 mmol) and dipalladium trisdibenzylideneacetone (41 mg, 0.045 mmol) were suspended under an atmosphere of argon in dry dimethylformamide (5 mL). After stirring at room temperature for 40 min 7-[(tert-butoxycarbonyl)amino]-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (0.5 g, 0.902 mmol) was added and the reaction mixture was heated to 90° C. Over 30 min zinc cyanide (159 mg, 1.353 mmol) was added in small portions. After complete addition stirring was continued at 90° C. for 2 h. The reaction mixture was cooled to room temperature diluted with dichloromethane (50 mL), washed with saturated NaHCO 3 (3×10 mL). The organic layer was dried (MgSO 4 ) and concentrated in vacuo. The crude product was purified by flash chromatography (dichloromethane, silica gel). Yield: 97 mg (0.225 mmol, 25%).
ESI-MS [M+Na + ]=453 Calculated for C 23 H 24 Cl 2 N 2 O 2 =430.
Example 35
7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-ol trifluoroacetate (salt)









Cf. example 34a
ESI-MS [M+H + ]=322 Calculated for C 17 H 17 Cl 2 NO=321.
Example 36
1-(4-chlorobenzyl)-7-(difluoromethoxy)-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
36.1 tert-Butyl [1-(4-chlorobenzyl)-7-(difluoromethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









Tert-butyl [1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (180 mg, 0.464 mmol, prepared analogously to tert-butyl [1-(3,4-dichlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate, cf. Example 34.2 and potassium hydroxide (1.4 g, 25 mmol) were suspended in acetonitrile (4 mL). After stirring the two phase system for 45 min at room temperature the reaction mixture was cooled to −15° C. and a solution of 2-chloro-2,2-difluoro-1-phenylethanone (442 mg, 2.32 mmol) in acetonitrile (1 mL) was added dropwise over 30 min. The reaction mixture was warmed to room temperature and then heated at 80° C. for 2 h. The reaction mixture was cooled to room temperature and diluted with ethyl acetate. The aqueous layer was extracted with ethyl acetate. The combined extracts were dried (MgSO 4 ) and concentrated in vacuo. The crude product was purified by flash chromatography (dichloromethane, silica gel). Yield: 30 mg (0.069 mmol, 15%).
ESI-MS [M-isobutene+CH3CN+H + ]=423 Calculated for C 23 H 26 ClF 2 NO 3 =437.
36.2 1-(4-Chlorobenzyl)-7-(difluoromethoxy)-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride









tert-Butyl [1-(4-chlorobenzyl)-7-(difluoromethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (30 mg, 0.069 mmol) was dissolved in dichloromethane (2 mL). 5N isopropanolic hydrochloric acid (0.3 mL) were added and the reaction mixture was stirred at room temperature for 3 h. The solvents were evaporated in vacuo. Yield: 26 mg (0.069 mmol, 100%, colorless solid).
ESI-MS [M+H + ]=338 Calculated for C 18 H 18 ClF 2 NO=337.
Example 37
Benzyl [1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









tert-Butyl [1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (2 g, 6.95 mmol, prepared analogously to tert-butyl [1-(3,4-dichlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate, cf. example 34.2 were suspended in dimethylformamide (40 mL). Triethylamine (0.969 mL, 6.95 mmol) and benzyl carbonochloridate (1.186 g, 6.95 mmol) were added. The reaction mixture was stirred at room temperature over night. The solvent was evaporated in vacuo. To the crude product ethyl acetate and water were added. The aqueous layer was extracted with ethyl acetate. The combined organic layers were dried (MgSO 4 ) and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 393 mg (0.931 mmol, 13.4%, colorless foam).
ESI-MS [M+H + ]=422 Calculated for C 25 H 24 ClNO 3 =421.
Example 38
tert-Butyl [7-(aminomethyl)-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









tert-Butyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (30 mg, 0.07 mmol, cf. example 34d) were dissolved in methanol (3 mL). Raney nickel (10 mg) was added and the reaction mixture stirred at room temperature under an atmosphere of hydrogen for 4 h. The catalyst was removed by filtration and the methanol was evaporated in vacuo. Yield: 18 mg (0.041 mmol, 59%).
ESI-MS [M+H + ]=435 Calculated for C 23 H 28 Cl 2 N 2 O 2 =434.
Example 39
tert-Butyl [1-(3,4-dichlorobenzyl)-7-{[(propylsulfonyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









tert-Butyl [7-(aminomethyl)-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (120 mg, 0.276 mmol, cf. Example 38) was dissolved in dichloromethane (5 mL). 4-Dimethylaminopyridine (35 mg, 0.289 mmol) was added. After stirring at room temperature for 5 min propane-1-sulfonyl chloride (39 mg, 0.031 mmol) was added and stirring was continued over night. The reaction mixture was diluted with dichloromethane and washed successively with 0.5 N hydrochloric acid (2×2 mL) and saturated NaHCO 3 (1×2 mL). The organic phase was dried (MgSO 4 ) and concentrated in vacuo. The crude product was used for the next step without further purification. Yield: 125 mg (0.231 mmol, 84%).
ESI-MS [M+Na + ]=563 Calculated for C 26 H 34 Cl 2 N 2 O 4 S=540.
Example 40
N-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









Tert-butyl [1-(3,4-dichlorobenzyl)-7-{[(propylsulfonyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (120 mg, 0.222 mmol, cf. example 39) was dissolved in 5 N isopropanolic hydrochloric acid (2 mL). The reaction mixture was stirred at room temperature for 1 h. The solvent was evaporated and the product was dried in vacuo. Yield: 101 mg (0.211 mmol, 95%).
ESI-MS [M+H + ]=441 Calculated for C 21 H 26 Cl 2 N 2 O 2 S=440.
Example 41
N-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-3-fluoropropane-1-sulfonamide hydrochloride









The compound was prepared analogously to example 40 using 3-fluoropropane-1-sulfonyl chloride in place of n-propane-1-sulfonyl chloride.
ESI-MS [M+H + ]=459 Calculated for C 21 H 25 Cl 2 FN 2 O 2 S=458.
Example 42
N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide trifluoroacetate









N-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride (40 mg, 0.084 mmol, cf. example 40) were dissolved in methanol (4 mL) and hydrogenated at the H-cube (1 h, 40° C., 30 bar, 20% Pd/C). The solvent was evaporated and the crude product was purified by preparative HPLC (xTerra prep MS C18 column, 19×150 mm, 5 μm; gradient: water, acetonitrile with 0.1% trifluoroacetic acid, flow: 20 mL/min). Yield: 4.9 mg (0.0102 mmol, 12%).
ESI-MS [M+H + ]=373 Calculated for C 21 H 28 N 2 O 2 S=372.
Example 43
N-{[cis-7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}cyclobutanesulfonamide hydrochloride









The compound was prepared analogously to example 40 using cyclobutylsulfonyl chloride in place of n-propane-1-sulfonyl chloride.
ESI-MS [M+H + ]=385 Calculated for C 22 H 28 N 2 O 2 S=384.
Example 44
N-{[cis-7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-cyclopropylmethanesulfonamide hydrochloride









The compound was prepared analogously to example 40 using cyclopropylmethanesulfonyl chloride in place of n-propane-1-sulfonyl chloride.
ESI-MS [M+H + ]=385 Calculated for C 22 H 28 N 2 O 2 S=384.
Example 45
N-{[cis-7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-N-methylpropane-1-sulfonamide hydrochloride









Tert-butyl-1-benzyl-7-(propylsulfonamidomethyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (35 mg, 0.074 mmol, prepared analog to example 40) was dissolved in acetonitrile (1 mL). Cesium carbonate (29 mg, 0.09 mmol)) and methyliodide (12 μl, 0.19 mmol) were added successively and the reaction mixture was heated in the microwave to 100° C. for 3 h. The solvents were evaporated in vacuo. The residue was treated with dichloromethane and washed with water. The organic layer was dried (MgSO 4 ) and concentrated. The crude product was dissolved in isopropanol and treated with 5 M hydrochloric acid in isopropanol. The solvent was evaporated in vacuo to yield the final product as colorless solid. Yield: 18 mg (0.043 mmol, 58%).
ESI-MS [M+H + ]=387 Calculated for C 22 H 30 N 2 O 2 S=386.
Example 46
{1-(3-Chloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester
46.1 7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester was prepared in analogy to example 1 using 1-bromomethyl-3-chloro-benzene in place of 4-(bromomethyl)-1,2-dichlorobenzene.
ESI-MS [M+H + ]=503 Calculated for C 27 H 35 ClN 2 O 5 =502
46.2 {1-(3-Chloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









{1-(3-Chloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester was prepared starting from 7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester from previous step in analogy to example 2 using 1-methyl-1H-pyrazole-4-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=547 Calculated for C 26 H 31 ClN 4 O 5 =546
Example 47
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared in analogy to example 3 starting from {1-(3-Chloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 46)
ESI-MS [M+H + ]=475 Calculated for C 23 H 27 ClN 4 O 3 S=474
Example 48
1-Methyl-1H-imidazole-4-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









1-Methyl-1H-imidazole-4-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride was prepared in three steps from 7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester in analogy to example 47 using 1-Methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=475 Calculated for C 23 H 27 ClN 4 O 3 S=474
Example 49
{1-(3-Chloro-benzyl)-7-[2-(2,4-dimethyl-thiazole-5-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 2,4-dimethyl-thiazole-5-sulfonyl chloride.
ESI-MS [M+H + ]=578 Calculated for C 27 H 32 ClN 3 O 5 S 2 =577
Example 50
{1-(3-Chloro-benzyl)-7-[2-(thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-Butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using thiophene-2-sulfonyl chloride.
ESI-MS [M+H + ]=549 Calculated for C 26 H 29 ClN 2 O 5 S 2 =548
Example 51
{1-(3-Chloro-benzyl)-7-[2-(5-chloro-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 5-Chloro-thiophene-2-sulfonyl chloride.
ESI-MS [M+H + ]=583 Calculated for C 26 H 28 Cl 2 N 2 O 5 S 2 =582
Example 52
{1-(3-Chloro-benzyl)-7-[2-(2-methyl-3H-imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 2-Methyl-3H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=547 Calculated for C 26 H 31 ClN 4 O 5 S=546
Example 53
{1-(3-Chloro-benzyl)-7-[2-(5-methyl-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 5-Methyl-thiophene-2-sulfonyl chloride.
ESI-MS [M+H + ]=563 Calculated for C 27 H 31 ClN 2 O 5 S 2 =562
Example 54
{1-(3-Chloro-benzyl)-7-[2-(4-methyl-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 4-Methyl-thiophene-2-sulfonyl chloride.
ESI-MS [M+H + ]=563 Calculated for C 27 H 31 ClN 2 O 5 S 2 =562
Example 55
Propane-1-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in three steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 48 using propane-1-sulfonyl chloride.
ESI-MS [M+H + ]=437 Calculated for C 22 H 29 ClN 2 O 3 S=436
Example 56
Thiophene-2-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide









Prepared in one step from {1-(3-chloro-benzyl)-7-[2-(thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester in analogy to example 48.
ESI-MS [M+H + ]=477 Calculated for C 23 H 25 ClN 2 O 3 S 2 =476
Example 57
2,4-Dimethyl-thiazole-5-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide









Prepared in one step from {1-(3-Chloro-benzyl)-7-[2-(2,4-dimethyl-thiazole-5-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 49) in analogy to example 48.
ESI-MS [M+H + ]=506 Calculated for C 24 H 28 ClN 3 O 3 S 2 =505
Example 58
2-Methyl-3H-imidazole-4-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide









Prepared in one step from {1-(3-Chloro-benzyl)-7-[2-(2-methyl-3H-imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 52) in analogy to example 48.
ESI-MS [M+H + ]=475 Calculated for C 23 H 27 ClN 4 O 3 S=474
Example 59
5-Chloro-thiophene-2-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide









Prepared in one step from {1-(3-chloro-benzyl)-7-[2-(5-chloro-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 51) in analogy to example 48.
ESI-MS [M+H + ]=511 Calculated for C 23 H 24 Cl 2 N 2 O 3 S 2 =510
Example 60
{1-(3-Chloro-benzyl)-7-[2-(2,5-dimethyl-thiophene-3-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 2,5-Dimethyl-thiophene-3-sulfonyl chloride.
ESI-MS [M+H + ]=577 Calculated for C 28 H 33 ClN 2 O 5 S 2 =576
Example 61
{1-(3-Chloro-benzyl)-7-[2-(1-ethyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 1-Ethyl-1H-pyrazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=561 Calculated for C 27 H 33 ClN 4 O 5 S=560
Example 62
{1-(2,4-Dichloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared as described for example 46 using 1-bromomethyl-2,4-dichloro-benzene in place of 4-(bromomethyl)-3-chlorobenzene.
ESI-MS [M+H + ]=581 Calculated for C 26 H 30 Cl 2 N 4 O 5 S=580
Example 63
{1-(2,4-Dichloro-benzyl)-7-[2-(thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared as described for example 62 using thiophene-2-sulfonyl chloride in place of 1-methyl-1H-pyrazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=583 Calculated for C 26 H 28 Cl 2 N 4 O 5 S 2 =582
Example 64
{1-(2,4-Dichloro-benzyl)-7-[2-(5-methyl-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared as described for example 62 using 5-methyl-thiophene-2-sulfonyl chloride in place of 1-Methyl-1H-pyrazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=597 Calculated for C 27 H 30 Cl 2 N 2 O 5 S 2 =596
Example 65
[1-(3-Chloro-benzyl)-7-(2-ethanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using ethane-sulfonyl chloride.
ESI-MS [M+H + ]=495 Calculated for C 24 H 31 ClN 2 O 5 S=494
Example 66
1-Ethyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in one step from {1-(3-chloro-benzyl)-7-[2-(1-ethyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 61) in analogy to example 48.
ESI-MS [M+H + ]=489 Calculated for C 24 H 29 ClN 4 O 3 S=488
Example 67
4-Methyl-thiophene-2-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in one step from {1-(3-chloro-benzyl)-7-[2-(2-methyl-3H-imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 53) in analogy to example 48.
ESI-MS [M+H + ]=491 Calculated for C 24 H 27 ClN 2 O 3 S 2 =490
Example 68
5-Methyl-thiophene-2-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in one step from {1-(3-chloro-benzyl)-7-[2-(5-methyl-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 53) in analogy to example 48.
ESI-MS [M+H + ]=491 Calculated for C 24 H 27 ClN 2 O 3 S 2 =490
Example 69
2,5-Dimethyl-thiophene-3-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in one step from {1-(3-Chloro-benzyl)-7-[2-(2,5-dimethyl-thiophene-3-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 60) in analogy to example 48.
ESI-MS [M+H + ]=505 Calculated for C 25 H 29 ClN 2 O 3 S 2 =504
Example 70
Ethanesulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in one step from [1-(3-chloro-benzyl)-7-(2-ethanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester (example 65) in analogy to example 48.
ESI-MS [M+H + ]=423 Calculated for C 21 H 27 ClN 2 O 3 S=422
Example 71
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(2,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in one step from {1-(2,4-dichloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 62) in analogy to example 48.
ESI-MS [M+H + ]=509 Calculated for C 23 H 26 Cl 2 N 4 O 3 S=508
Example 72
Thiophene-2-sulfonic acid {2-[7-amino-8-(2,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in one step from {1-(2,4-dichloro-benzyl)-7-[2-(thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 63) in analogy to example 48.
ESI-MS [M+H + ]=511 Calculated for C 23 H 24 Cl 2 N 2 O 3 S 2 =510
Example 73
5-Methyl-thiophene-2-sulfonic acid {2-[7-amino-8-(2,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in one step from {1-(2,4-dichloro-benzyl)-7-[2-(5-methyl-thiophene-2-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 64) in analogy to example 48.
ESI-MS [M+H + ]=525 Calculated for C 24 H 26 Cl 2 N 2 O 3 S 2 =524
Example 74
{1-(2,4-Dichloro-benzyl)-7-[2-(propane-1-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared as described for example 62 using propane-1-sulfonyl chloride in place of 1-methyl-1H-pyrazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=543 Calculated for C 25 H 32 Cl 2 N 2 O 5 S=542
Example 75
Propane-1-sulfonic acid {2-[7-amino-8-(2,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in one step from {1-(2,4-dichloro-benzyl)-7-[2-(propane-1-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester (example 74) in analogy to example 48.
ESI-MS [M+H + ]=471 Calculated for C 22 H 28 Cl 2 N 2 O 3 S=470
Example 76
(1-(4-Chloro-benzyl)-7-{2-[methyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester
76.1 2-(N-methylpropylsulfonamido)ethyl propane-1-sulfonate









To a cooled solution (0-5° C.) of 2-(methylamino)ethanol (8.56 ml, 107 mmol) in 100 ml DCM was added dropwise a solution of propane-1-sulfonyl chloride (13.1 ml, 117 mmol) in 50 ml DCM over an 1 h period. The resulting mixture was stirred at room temperature over night. Water and 10% citric acid were added and then was extracted with DCM, dried over MgSO 4 , filtrated and evaporated to obtain a yellow/orange oil. (13.6 g) Chromatography afforded 2.75 g of product.
76.2 (1-(4-Chloro-benzyl)-7-{2-[methyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester









A solution of ethyl 1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (0.128 g, 0.355 mmol) in DMF under N 2 was treated with sodium hydride (0.014 g, 0.568 mmol) and the reaction was stirred for 30 minutes at room temperature. A solution of 2-(N-methylpropylsulfonamido)ethyl propane-1-sulfonate (0.102 g, 0.355 mmol) (see step 1) in DMF was added and the reaction mixture was stirred at ambient temperature over night. The mixture was portioned between ethyl acetate and water. The organic layer was washed with water, dried (MgSO 4 ), filtrated and evaporated to afford brown/white crystals. After addition of a few drops of ethyl acetate/cyclohexane (1:4) a white precipitate formed. Yield 43 mg
ESI-MS [M+H + ]=523 Calculated for C 26 H 35 ClN 2 O 5 S=522
Example 77
Propane-1-sulfonic acid {2-[7-amino-8-(4-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-methyl-amide hydrochloride









Prepared in one step from (1-(4-chloro-benzyl)-7-{2-[methyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester (example 76) in analogy to example 48.
ESI-MS [M+H + ]=451 Calculated for C 23 H 31 ClN 2 O 3 S=450
Example 78
(1-(3-Chloro-benzyl)-7-{2-[methyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester









Prepared from [1-(3-chloro-benzyl)-7-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester as described example 77.
ESI-MS [M+H + ]=523 Calculated for C 26 H 35 ClN 2 O 5 S=522
Example 79
Propane-1-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro naphthalen-2-yloxy]-ethyl}-methyl-amide hydrochloride









Prepared in one step from (1-(3-chloro-benzyl)-7-{2-[methyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester (example 78) in analogy to example 48.
ESI-MS [M+H + ]=451 Calculated for C 23 H 31 ClN 2 O 3 S=450
Example 80
{1-(3-Chloro-benzyl)-7-[2-(1-methyl-1H-imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 1-Methyl-1H-imidazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=547 Calculated for C 26 H 31 ClN 4 O 5 S=546
Example 81
{1-(3-Chloro-benzyl)-7-[2-(1-difluoromethyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in two steps from 7-(2-tert-butoxycarbonylamino-ethoxy)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 46 using 1-difluoromethyl-1H-pyrazole-4-sulfonyl chloride.
ESI-MS [M+H + ]=583 Calculated for C 26 H 29 CF 2 N 4 O 5 S=582
Example 82
1-(3-Chloro-benzyl)-7-[(R)-1-(propane-1-sulfonyl)-pyrrolidin-2-ylmethoxy]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
82.1 (Propane-1-sulfonic acid (R)-1-(propane-1-sulfonyl)-pyrrolidin-2-ylmethyl ester









Prepared as described for 2-(N-methylpropylsulfonamido)ethyl propane-1-sulfonate (example 76, step 1 using (R)-1-pyrrolidin-2-yl-methanol instead of 2-(methylamino)ethanol.
82.2 1-(3-Chloro-benzyl)-7-[(R)-1-(propane-1-sulfonyl)-pyrrolidin-2-ylmethoxy]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared in two steps from (propane-1-sulfonic acid (R)-1-(propane-1-sulfonyl)-pyrrolidin-2-ylmethyl ester (see previous step) and ethyl 1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate as described for example 77.
ESI-MS [M+H + ]=477 Calculated for C 25 H 33 ClN 2 O 3 S=476
Example 83
1-(3-Chloro-benzyl)-7-[1-(propane-1-sulfonyl)-azetidin-3-yloxy]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
83.1 1-(Propane-1-sulfonyl)-azetidin-3-ol









To a cooled solution (0-5° C.) of azetidin-3-ol hydrochloride (1 g, 9.13 mmol) in 10 ml dichloromethane containing diisopropyl ethyl amine (2,391 ml, 13.69 mmol) was added dropwise a solution of propane-1-sulfonyl chloride (1,126 ml, 10.04 mmol) dissolved in 5 ml dichloromethane over an 1 h period. The mixture was allowed to warm up to room temperature and was stirred over night. Citric acid (10%) was added, extracted with dichloromethane, dried over MgSO 4 , filtered and the solvent was evaporated to obtain 597 mg of a yellow oil, which was purified by chromatography (yield 470 mg)
83.2 Methanesulfonic acid 1-(propane-1-sulfonyl)-azetidin-3-yl ester









To a solution of 1-(propane-1-sulfonyl)-azetidin-3-ol (236 mg, 1.317 mmol) in pyridine was added drop wise methane sulfonyl chloride (205 μl, 2.63 mmol) at 0° C. The mixture was allowed to warm up to room temperature and was stirred for 3 h. Dichloromethane was added. The mixture was subsequently washed with water, saturated NaHCO 3 and brine, dried (MgSO 4 ), and filtrated. The solvent was evaporated to obtain 293 mg of crude product which was used without further purification.
83.3 1-(3-Chloro-benzyl)-7-[1-(propane-1-sulfonyl)-azetidin-3-yloxy]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared in two steps from methanesulfonic acid 1-(propane-1-sulfonyl)-azetidin-3-yl ester (see previous step) and ethyl 1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate as described for example 77.
ESI-MS [M+H + ]=449 Calculated for C 23 H 29 ClN 2 O 3 S=448
Example 84
1-(3-Chloro-benzyl)-7-(3-ethanesulfonyl-propoxy)-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared in two steps from 1-chloro-3-ethanesulfonyl-propane (see: Synthetic Communications, 19(9-10), 1583-91; 1989) and ethyl 1-(4-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate in analogy to example 77.
ESI-MS [M+H + ]=422 Calculated for C 22 H 28 ClNO 3 S=421
Example 85
Cyclohexanesulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Cyclohexanesulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride was prepared in analogy to example 3 using cyclohexyl-sulfonyl chloride in place of 1-methyl-1H-imidazole-4-sulfonyl chloride. ESI-MS [M+H + ]=511 Calculated for C 25 H 32 Cl 2 N 2 O 3 S=510
Example 86
2-Trimethylsilanyl-ethanesulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









2-Trimethylsilanyl-ethanesulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amid hydrochloride was prepared in analogy to example 3.
ESI-MS [M+H + ]=529 Calculated for C 24 H 34 Cl 2 N 2 O 3 SSi=528
Example 87
N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-(5-methyl-isoxazol-3-yl)-methanesulfonamide hydrochloride









N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-(5-methyl-isoxazol-3-yl)-methanesulfonamide hydrochloride was prepared in analogy to example 3.
ESI-MS [M+H + ]=524 Calculated for C 24 H 27 Cl 2 N 3 O 4 S=523
Example 88
Cyclobutanesulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









88.1 1-(1-(3,4-Dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)pyrrolidine









1-(3,4-Dichlorobenzyl)-7-methoxy-3,4-dihydronaphthalen-2(1H)-one (5.5 g, 16.4 mmol, example 1), pyrrolidine (1.40 g, 19.7 mmol), and p-toluenesulfonic acid monohydrate (31.0 mg, 0.164 mmol) were dissolved in toluene (100 ml) and refluxed for 2 h using a Dean-Stark condenser. The solvent was removed and after addition of MeOH (50 ml) and sodium cyanohydride (1.57 g, 24.6 mmol) the mixture was stirred for 4 d at room temperature under nitrogen. Water was added, the organic phase separated and the aqueous phase extracted with ethyl acetate. The combined organic layers were washed with saturated NaCl solution, dried over MgSO 4 , and concentrated to afford a residue that was purified by flash chromatography (silica gel, MeOH/CH 2 Cl 2 3:97→5:95). The beige solid product (1.6 g, 25%) was obtained from precipitation in ethyl acetate/diisopropylether (1:1).
88.2 8-(3,4-Dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol









1-(1-(3,4-Dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)pyrrolidine (1.6 g, 4.10 mmol) was dissolved in CH 2 Cl 2 (100 ml) and BBr 3 (1 molar in CH 2 Cl 2 , 12.3 ml, 12.3 mmol) was added at −10° C. It was stirred for 2 h after which time the temperature rose to room temperature. Ice water was added, the organic phase separated and the aqueous phase extracted with CH 2 Cl 2 . The combined organic layers were washed with saturated NaHCO 3 and NaCl solution, dried over Na 2 SO 4 , and concentrated to afford a residue. The beige solid product (1.2 g, 78%) was obtained from precipitation in ethyl acetate.
88.3 tert-Butyl 2-(8-(3,4-dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethylcarbamate









NaH in paraffin (0.278 g, 6.38 mmol, 55% in paraffin) was washed with n-hexane and suspended in DMA (30 ml). 8-(3,4-Dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol (1.2 g, 3.19 mmol) in DMA (20 ml) was added. After stirring for 1 h at room temperature tert-butyl 2-bromoethylcarbamate (2.14 g, 6.38 mmol) was added in portions and the mixture was stirred for 48 h. Water was added and the aqueous phase was extracted with ethyl acetate. The combined organic layers were washed with saturated NaCl solution, dried over Na 2 SO 4 , and concentrated to afford a residue that was purified by flash chromatography (silica gel, MeOH/CH 2 Cl 2 3:97). The product (1.6 g, 97%) was obtained as a yellow oil.
88.4 2-(8-(3,4-Dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethanamine hydrochloride









tert-Butyl 2-(8-(3,4-dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethylcarbamate (1.6 g, 3.08 mmol) was dissolved in CH 2 Cl 2 (70 ml) and HCl in iPrOH was added. It was stirred for 14 h at room temperature after during which time the temperature rose to room temperature. The solvent was removed to obtain white salt (1.2 g, 85%).
88.5 Cyclobutanesulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









2-(8-(3,4-Dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethanamine (120 mg, 0.286 mmol), para-(N,N-dimethylamino) pyridine (1.40 g, 19.7 mmol), and cyclobutanesulfonyl chloride (46.5 mg, 0.30 mmol) were dissolved in CH 2 Cl 2 (20 ml) and stirred for 14 h at room temperature. 0.5N HCl was added, the organic phase separated and the aqueous phase extracted with CH 2 Cl 2 . The combined organic layers were washed with water, NaHCO 3 solution, and saturated NaCl solution, dried over Na 2 SO 4 , and concentrated to afford a residue that was purified by flash chromatography (silica gel, MeOH/CH 2 Cl 2 3:97→5:95). The white solid product (164 mg, 32%) was trans-ferred to an HCl salt and precipitated from diisopropyl ether.
ESI-MS [M+H + ]=537 Calculated for C 27 H 34 Cl 2 N 2 O 3 S=536
Example 89
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-methyl-amide hydrochloride









N-(2-(8-(3,4-Dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride (41 mg, 0.068 mmol, Example 91, iodomethane (11.6 mg, 0.082 mmol), caesium carbonate (49.0 mg, 0.150 mmol) were dissolved in acetonitrile (3 ml) and stirred for 1 h at 100° C. in the microwave. After addition of another iodomethane (11.6 mg, 0.082 mmol) and caesium carbonate (49.0 mg, 0.150 mmol) it was stirred for another 1 h at 100° C. in the microwave. Water and CH 2 Cl 2 were added, the organic phase separated and the aqueous phase extracted with CH 2 Cl 2 . The combined organic layers were washed with saturated NaCl solution, dried over Na 2 SO 4 , and concentrated to afford a residue that was purified by flash chromatography (silica gel, MeOH/CH 2 Cl 2 3:97→5:95). The white solid product (42 mg, 38%) was transferred to an HCl salt and precipitated from diisopropyl ether. ESI-MS [M+H + ]=577 Calculated for C 28 H 34 Cl 2 N 4 O 3 S=576
Example 90
Butane-1-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Butane-1-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared in analogy to example 3.
ESI-MS [M+H + ]=485 Calculated for C 23 H 30 Cl 2 N 2 O 3 S=484
Example 91
Propane-2-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Propane-2-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=471 Calculated for C 22 H 28 Cl 2 N 2 O 3 S=470
Example 92
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









1-Methyl-1H-pyrazole-4-sulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared in analogy to example 88.
ESI-MS [M+H + ]=563 Calculated for C 27 H 32 Cl 2 N 4 O 3 S=562
Example 93
2-Ethoxy-ethanesulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









2-Ethoxy-ethanesulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=501 Calculated for C 23 H 30 Cl 2 N 2 O 4 S=500
Example 94
Cyclobutanesulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-methyl-amide hydrochloride









Cyclobutanesulfonic acid {2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-methyl-amide hydrochloride was prepared from N-(2-(8-(3,4-dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)cyclobutanesulfonamide hydrochloride (example 88) in analogy to example 89. ESI-MS [M+H + ]=551 Calculated for C 28 H 36 Cl 2 N 2 O 3 S=550
Example 95
N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide hydrochloride









N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=483 Calculated for C 23 H 28 Cl 2 N 2 O 3 S=482
Example 96
Propane-1-sulfonic acid {2-[7-amino-8-(4-methoxy-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Propane-1-sulfonic acid {2-[7-amino-8-(4-methoxy-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared in analogy to example 3.
ESI-MS [M+H + ]=433 Calculated for C 23 H 32 N 2 O 4 S=432
Example 97
N-[2-(7-Amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methanesulfonamide hydrochloride









N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)methanesulfonamide hydrochloride (50.0 mg, 0.104 mmol), Pd—C 10% (1.10 mg), and hydrazine monohydrate (522 mg, 10.4 mmol) were suspended in ethanol (5 ml) and stirred for 4 h under reflux. Water and CH 2 Cl 2 were added, the mixture filtered, and the filtrate was extracted with CH 2 Cl 2 . The combined organic layers were washed with water, saturated NaCl solution, dried over Na 2 SO 4 , and concentrated to afford a residue that was purified by precipitation from diisopropylether. The residue was transferred to an HCl salt and finally gave the product as a white solid (31 mg, 72%).
ESI-MS [M+H + ]=375 Calculated for C 20 H 26 N 2 O 3 S=374
Example 98
1-Methyl-1H-imidazole-4-sulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide hydrochloride









1-Methyl-1H-imidazole-4-sulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide hydrochloride was prepared in analogy to example 3 and 89.
ESI-MS [M+H + ]=455 Calculated for C 24 H 30 N 4 O 3 S=454
Example 99
N-[2-(7-Amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-benzenesulfonamide hydrochloride









N-[2-(7-Amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-benzenesulfonamide hydrochloride was prepared from N-{2-[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-benzenesulfonamide hydrochloride (example 16) in analogy to example 3 and 97.
ESI-MS [M+H + ]=437 Calculated for C 25 H 28 N 2 O 3 S=436
Example 100
3,3,3-Trifluoro-propane-1-sulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]amide hydrochloride









3,3,3-Trifluoro-propane-1-sulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-amide hydrochloride was prepared in analogy to example 3 and 97.
ESI-MS [M+H + ]=457 Calculated for C 22 H 27 F 3 N 2 O 3 S=456
Example 101
1-Methyl-1H-imidazole-4-sulfonic acid [2-(8-benzyl-7-pyrrolidin-1-yl-5,6,7,8-tetrahydronaphthalen-2-yloxy)-ethyl]-methyl-amide hydrochloride









N-(2-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-N,1-dim ethyl-1H-imidazole-4-sulfonamide hydrochloride (98), 1,4-dibromobutane (49.9 mg, 0.231 mmol), and triethylamine (31.2 mg, 0.308 mmol) were dissolved in acetonitrile (3 ml) and stirred for 2 h at 130° C. in the microwave. Water and ethyl acetate were added and the organic phase was separated. After extraction of the aqueous phase with ethylacetate the combined organic layers were washed with saturated NaCl solution, dried over Na 2 SO 4 , and concentrated to afford a residue a residue that was purified by flash chromatography (silica gel, MeOH/CH 2 Cl 2 5:95). The residue was transferred to an HCl salt and finally gave the product as a white solid (8.5 mg, 10%) after precipitation from diisopropylether.
ESI-MS [M+H + ]=509 Calculated for C 28 H 36 N 4 O 3 S=508
Example 102
Cyclopropanesulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-amide hydrochloride









Cyclopropanesulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-amide hydrochloride was prepared in analogy to example 3 and 97.
ESI-MS [M+H + ]=401 Calculated for C 22 H 28 N 2 O 3 S=400
Example 103
N-[2-(7-Amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-propionamide hydrochloride









Ethyl 7-(2-aminoethoxy)-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate hydrochloride (example 2.1, 100 mg, 0.229 mmol) and N,N-dimethyl amino pyridine (30.7 mg, 0.252 mmol) were dissolved in CH 2 Cl 2 (20 ml) and propionyl chloride (30.7 mg, 0.252 mmol) was added at RT. After stirring at RT for 14 h 0.5 N HCl was added and the mixture was extracted with CH 2 Cl 2 . The combined organic layers were washed with saturated NaHCO 3 and NaCl solution, dried over Na 2 SO 4 , and concentrated to afford a residue. White solid ethyl 1-(3,4-dichlorobenzyl)-7-(2-propionamidoethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (98 mg, 87%) was obtained from precipitation in ethyl acetate. Further transformation in analogy to example 2 and 97 finally gave N-[2-(7-Amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-propionamide hydrochloride.
ESI-MS [M+H + ]=353 Calculated for C 22 H 28 N 2 O 2 =352
Example 104
1-Methyl-1H-[1,2,4]triazole-3-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide









1-Methyl-1H-[1,2,4]triazole-3-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide was prepared in analogy to example 3.
ESI-MS [M+H + ]=510 Calculated for C 22 H 25 Cl 2 N 5 O 3 S=509
Example 105
1-Methyl-1H-imidazole-4-sulfonic acid [2-(7-azetidin-1-yl-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide









1-Methyl-1H-imidazole-4-sulfonic acid [2-(7-azetidin-1-yl-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide was prepared in analogy to example 101. ESI-MS [M+H + ]=495 Calculated for C 27 H 34 N 4 O 3 S=494
Example 106
N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclobutyl-methanesulfonamide hydrochloride









N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclobutyl-methanesulfonamide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=497 Calculated for C 24 H 30 Cl 2 N 2 O 3 S=496
Example 107
Propane-1-sulfonic acid {2-[7-amino-8-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Propane-1-sulfonic acid {2-[7-amino-8-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride was prepared in analogy to example 3.
ESI-MS [M+H + ]=421 Calculated for C 22 H 29 FN 2 O 3 S=420
Example 108
N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-N-methyl-methanesulfonamide hydrochloride









N-{2-[7-Amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-N-methyl-methanesulfonamide hydrochloride was prepared in analogy to example 11.
ESI-MS [M+H + ]=497 Calculated for C 24 H 30 Cl 2 N 2 O 3 S=496
Example 109
1-Methyl-1H-pyrazole-4-sulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide









1-Methyl-1H-pyrazole-4-sulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide was prepared in analogy to example 3 and 89.
ESI-MS [M+H + ]=455 Calculated for C 24 H 30 N 4 O 3 S=454
Example 110
N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-N-ethyl-1-methyl-1H-pyrazole-4-sulfonamide









N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-N-ethyl-1-methyl-1H-pyrazole-4-sulfonamide was prepared in analogy to example 11.
ESI-MS [M+H + ]=537 Calculated for C 25 H 30 Cl 2 N 4 O 3 S=536
Example 111
1-Methyl-1H-pyrazole-4-sulfonic acid [2-(8-benzyl-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide hydrochloride









1-Methyl-1H-pyrazole-4-sulfonic acid [2-(8-benzyl-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide hydrochloride was prepared in analogy to example 50.
ESI-MS [M+H + ]=509 Calculated for C 28 H 36 N 4 O 3 S=508
Example 112
1-Methyl-1H-pyrazole-4-sulfonic acid [2-(7-azetidin-1-yl-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide hydrochloride









1-Methyl-1H-pyrazole-4-sulfonic acid [2-(7-azetidin-1-yl-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-methyl-amide hydrochloride was prepared in analogy to example 50.
ESI-MS [M+H + ]=495 Calculated for C 27 H 34 N 4 O 3 S=494
Example 113
N-(2-(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-N-ethyl-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride









N-(2-(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-N-ethyl-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride was prepared in analogy to example 3 and 89. ESI-MS [M+H + ]=469 Calculated for C 25 H 32 N 4 O 3 S=468
Example 114
N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)pentane-1-sulfonamide hydrochloride









N-(2-(7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)pentane-1-sulfonamide hydrochloride was prepared in analogy to example 3.
ESI-MS [M+H + ]=499 Calculated for C 24 H 32 Cl 2 N 2 O 3 S=498
Example 115
N-(2-(8-(3,4-Dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









N-(2-(8-(3,4-Dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride was synthesized in analogy to example 88.
ESI-MS [M+H + ]=536 Calculated for C 27 H 32 Cl 2 N 4 O 3 S=535
Example 116
N-(2-(8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









N-(2-(8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride was prepared from N-(2-(8-(3,4-dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide (example 115) in analogy to 97.
ESI-MS [M+H + ]=495 Calculated for C 27 H 34 N 4 O 3 S=494
Example 117, 118
Enantiomere 1 and 2 of 116









The racemate of N-(2-(8-benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride (ex. 116) was separated by chiral chromatography on Chiracel AD (n-heptane/ethanol 35:65, 0.1% TEA, 9 ml/min) to deliver (after transfer to the salt form) (−)-N-(2-(8-benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride ([α]=−76.0° in MeOH, c=1.040 g/100 ml [ex. 117]) and (+)-N-(2-(8-benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride ([α]=−77.7° in MeOH, c=0.382 g/100 ml ex. 118]).
ESI-MS [M+H + ]=495 Calculated for C 27 H 34 N 4 O 3 S=494
Example 119
N-(2-(8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride









N-(2-(8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride was prepared from N-(2-(8-(3,4-dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide (example 114) in analogy to 97.
ESI-MS [M+H + ]=495 Calculated for C 27 H 34 N 4 O 3 S=494
Example 120
N-(2-{[7-Amino-8-(3-chloro-4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)propane-1-sulfonamide hydrochloride









N-(2-{[7-Amino-8-(3-chloro-4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)propane-1-sulfonamide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=455 Calculated for C 22 H 28 ClFN 2 O 3 S=454
Example 121
N-(2-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=415 Calculated for C 23 H 30 N 2 O 3 S=414
Example 122
N-(2-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-2-cyclopropylacetamide hydrochloride









N-(2-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-2-cyclopropylacetamide hydrochloride was synthesized in analogy to example 103. ESI-MS [M+H + ]=447 Calculated for C 24 H 28 Cl 2 N 2 O 2 =446
Example 123
N-(2-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)benzamide hydrochloride









N-(2-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)benzamide hydrochloride was synthesized in analogy to example 103. ESI-MS [M+H + ]=469 Calculated for C 26 H 26 Cl 2 N 2 O 2 =468
Example 124
N-(2-{[8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-N-ethyl-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride









N-(2-{[8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-N-ethyl-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride was synthesized from N-(2-(7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-N-ethyl-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride (example 113) in analogy to example 97.
ESI-MS [M+H + ]=523 Calculated for C 29 H 38 N 4 O 3 S=522
Example 125
N-(2-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-2-cyclopropylethanesulfonamide hydrochloride









N-(2-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-2-cyclopropylethanesulfonamide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=497 Calculated for C 24 H 30 Cl 2 N 2 O 3 S=496
Example 126
C-Cyclopropyl-N-{2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-N-methyl-methanesulfonamide hydrochloride









C-Cyclopropyl-N-{2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-N-methyl-methanesulfonamide hydrochloride was synthesized in analogy to examples 89, 97, 101.
ESI-MS [M+H + ]=551 Calculated for C 28 H 36 Cl 2 N 2 O 3 S=550
Example 127
N-(2-{[8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropyl-N-methylmethanesulfonamide hydrochloride









N-(2-{[8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropyl-N-methylmethanesulfonamide hydrochloride was synthesized from 1-cyclopropyl-N-(2-{[8-(3,4-dichlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-N-methylmethanesulfonamide hydrochloride in analogy to example 97. ESI-MS [M+H + ]=483 Calculated for C 28 H 38 N 2 O 3 S=482
Example 128
N-(2-{[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=449 Calculated for C 23 H 29 ClN 2 O 3 S=448
Example 129
N-(2-{[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropyl-N-methylmethanesulfonamide hydrochloride









N-(2-{[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropyl-N-methylmethanesulfonamide hydrochloride was prepared in analogy to example 3, N-methylation was performed according to 89.
ESI-MS [M+H + ]=463 Calculated for C 24 H 31 ClN 2 O 3 S=462
Example 130
N-[2-(7-Amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-C-cyclopropyl-N-methyl-methanesulfonamide hydrochloride









N-[2-(7-Amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-C-cyclopropyl-N-methyl-methanesulfonamide hydrochloride was prepared from N-(2-{[7-amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropyl-N-methylmethanesulfonamide hydrochloride (example 108) in analogy to example 97. ESI-MS [M+H + ]=429 Calculated for C 24 H 32 N 2 O 3 S=428
Example 131
N-(2-{[7-Amino-8-(3,4-difluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[7-Amino-8-(3,4-difluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was prepared in analogy to example 3. ESI-MS [M+H + ]=451 Calculated for C 23 H 28 F 2 N 2 O 3 S=450
Example 132
C-Cyclopropyl-N-{2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-methanesulfonamide hydrochloride









C-Cyclopropyl-N-{2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-methanesulfonamide hydrochloride was prepared in analogy to example 88.
ESI-MS [M+H + ]=537 Calculated for C 27 H 34 Cl 2 N 2 O 3 S=536
Example 133
N-(2-{[8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was prepared from C-cyclopropyl-N-{2-[8-(3,4-dichloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-methanesulfonamide hydrochloride (example 132) in analogy to example 97.
ESI-MS [M+H + ]=469 Calculated for C 27 H 36 N 2 O 3 S=468
Example 134
1-Cyclopropyl-N-[2-({8-(3,4-dichlorobenzyl)-7-[3-fluoropyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-2-yl}oxy)ethyl]methanesulfonamide









7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-ol (691 mg, 2.146 mmol, example 34), 2 eq of 1,4-dibromo-2-fluorobutane, and 3 eq of triethylamine were dissolved in acetonitrile (10 ml) and heated in the microwave for 2 h. Addition of water with ethylacetate, washing of the organic phase with saturated NaHCO 3 , NaCl, drying over Na 2 SO 4 and flash chromatography (silica gel, CH 2 Cl 2 /MeOH 95:5) gave 8-(3,4-dichlorobenzyl)-7-(3-fluoropyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol (330 mg, 39%). The ethylene sulfonamide side chain was added in analogy to examples 1, 7, 8 to give 1-cyclopropyl-N-[2-({8-(3,4-dichlorobenzyl)-7-[3-fluoropyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-2-yl}oxy)ethyl]methanesulfonamide.
ESI-MS [M+H + ]=555 Calculated for C 27 H 33 Cl 2 FN 2 O 3 S=554
Example 135
N-(2-{[7-(Azetidin-1-yl)-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide









N-(2-{[7-(Azetidin-1-yl)-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide was prepared in analogy to example 320. ESI-MS [M+H + ]=523 Calculated for C 26 H 32 Cl 2 N 2 O 3 S=522
Example 136
N-[2-({8-Benzyl-7-[3-fluoropyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-2-yl}oxy)ethyl]-1-cyclopropylmethanesulfonamide hydrochloride









N-[2-({8-Benzyl-7-[3-fluoropyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-2-yl}oxy)ethyl]-1-cyclopropylmethanesulfonamide hydrochloride was synthesized from 1-cyclopropyl-N-[2-({8-(3,4-dichlorobenzyl)-7-[3-fluoropyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-2-yl}oxy)ethyl]methanesulfonamide (example 134) in analogy to 97.
ESI-MS [M+H + ]=487 Calculated for C 27 H 35 FN 2 O 3 S=486
Example 137
N-(2-{[8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









The synthesis was performed starting from ethyl 1-benzyl-7-(2-(cyclopropylmethylsulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (synthesized in analogy to example 3), which was dissolved in THF (50 ml), after which LiAlH 4 was added at room temperature and the mixture was stirred for 8 h under reflux. Addition of 2N aqueous NaOH, extraction with CH 2 Cl 2 , washing of the organic layers with saturated NaHCO 3 solution and saturated NaCl solution and evaporation of the solvent gave a residue that was treated with iPrOH/HCl after which the product precipitated. After filtration a white salt (287 mg, 58%) were obtained.
ESI-MS [M+H + ]=429 Calculated for C 24 H 32 N 2 O 3 S=428
Example 138
1-Cyclopropyl-N-(2-{[8-(3-fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)methanesulfonamide hydrochloride









1-Cyclopropyl-N-(2-{[8-(3-fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)methanesulfonamide hydrochloride was synthesized in analogy to examples 264/88.
ESI-MS [M+H + ]=487 C 27 H 35 FN 2 O 3 S=486
Example 139
N-(2-{[7-(Azetidin-1-yl)-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[7-(Azetidin-1-yl)-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was synthesized in analogy to example 320.
ESI-MS [M+H + ]=473 C 26 H 33 FN 2 O 3 S=472
Example 140
N-(2-{[8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









N-(2-{[8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride was synthesized in analogy to examples 264/88
ESI-MS [M+H + ]=513 C 27 H 33 FN 4 O 3 S=512
Example 141
N-(2-{[7-(Azetidin-1-yl)-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









N-(2-{[7-(Azetidin-1-yl)-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride was synthesized in analogy to example 320.
ESI-MS [M+H + ]=499 C 26 H 31 FN 4 O 3 S=498
Example 142
N-(2-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was synthesized in analogy to example 320.
ESI-MS [M+H + ]=455 C 26 H 34 N 2 O 3 S=454
Examples 143, 144
Enantiomeres 1 and 2 of example 142









The racemate of N-(2-{[7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride (example 142) was separated by chiral chromatography on Chiracel AD (n-heptane/ethanol 35:65, 0.1% TEA, 9 ml/min) to deliver (after transfer to salt form) (−)-N-(2-(7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-cyclopropylmethanesulfonamide ([α]=−103.0° in MeOH, c=0.461 g/100 ml [example 143]) and (+)-N-(2-(7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-cyclopropylmethanesulfonamide succinate ([α]=+57.0° in MeOH, c=0.508 g/100 ml [example 144])
ESI-MS [M+H + ]=455 C 26 H 34 N 2 O 3 S=454
Example 145
N-(2-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide









N-(2-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide was synthesized in analogy to example 320.
ESI-MS [M+H + ]=481 C 26 H 32 N 4 O 3 S=480
Example 146









The racemate of N-(2-{[7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide (145) can be separated by chiral chromatography to deliver (after transfer to the salt form) (−)-N-(2-((7S,8R)-7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide fumarate ([α]=−81.4° in MeOH, c=0.409 g/100 ml).
ESI-MS [M+H + ]=481 Calculated for C 27 H 34 N 4 O 3 S=480
Example 147
N-(2-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)cyclobutanesulfonamide









N-(2-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)cyclobutanesulfonamide was synthesized in analogy to example 320. ESI-MS [M+H + ]=455 C 26 H 34 N 2 O 3 S=454
Example 148
Propane-1-sulfonic acid [2-(7-azetidin-1-yl-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-amide









Propane-1-sulfonic acid [2-(7-azetidin-1-yl-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-amide was synthesized in analogy to example 320.
ESI-MS [M+H + ]=443 C 25 H 34 N 2 O 3 S=442
Example 149
N-(2-{[8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide hydrochloride









N-(2-{[8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide hydrochloride was synthesized in analogy to examples 264/88.
ESI-MS [M+H + ]=512 C 28 H 34 FN 3 O 3 S=511
Example 150
N-(2-{[7-Amino-8-(3-chloro-5-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[7-Amino-8-(3-chloro-5-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was synthesized in analogy to example 3. ESI-MS [M+H + ]=467 C 23 H 28 ClFN 2 O 3 S=466
Example 151
N-(2-{[7-Amino-8-(3-chloro-5-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









N-(2-{[7-Amino-8-(3-chloro-5-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride was synthesized in analogy to example 3.
ESI-MS [M+H + ]=493 C 23 H 26 ClFN 4 O 3 S=492
Example 152
N-[2-({8-Benzyl-7-[3-fluoropyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-2-yl}oxy)ethyl]-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









N-[2-({8-Benzyl-7-[3-fluoropyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-2-yl}oxy)ethyl]-1-methyl-1H-imidazole-4-sulfonamide hydrochloride was synthesized in analogy to 264/88. ESI-MS [M+H + ]=513 C 27 H 33 FN 4 O 3 S=512
Example 153
N-(2-{[8-(3-Cyanobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide









N-(2-{[8-(3-Cyanobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide was synthesized in analogy to 264/88.
ESI-MS [M+H + ]=520 C 28 H 33 N 5 O 3 S=519
Example 154
N-(2-{[8-(3-Cyanobenzyl)-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









N-(2-{[8-(3-Cyanobenzyl)-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride was synthesized in analogy to example 88.
ESI-MS [M+H + ]=508 C 27 H 33 N 5 O 3 S=507
Example 155
N-(2-{[8-(3-Cyanobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[8-(3-Cyanobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was synthesized in analogy to examples 264/88.
ESI-MS [M+H + ]=494 C 28 H 35 N 3 O 3 S=493
Example 156
N-(2-{[8-(3-Cyanobenzyl)-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









N-(2-{[8-(3-Cyanobenzyl)-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride was synthesized in analogy to example 88.
ESI-MS [M+H + ]=482 C 27 H 35 N 3 O 3 S=481
Example 157
N-(2-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)propane-1-sulfonamide hydrochloride









N-(2-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)propane-1-sulfonamide hydrochloride was synthesized from Propane-1-sulfonic acid {2-[7-amino-8-(3,4-dichloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride (example 8) in analogy to example 97.
ESI-MS [M+H + ]=403 C 22 H 30 N 2 O 3 S=402
Example 158
N-(2-{[8-(3-Chloro-5-fluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









The synthesis was performed starting from ethyl 1-(3-chloro-5-fluorobenzyl)-7-(2-(cyclopropylmethylsulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (synthesized in analogy to example 3), which was dissolved in THF (50 ml), after which LiAlH 4 was added at room temperature and the mixture was stirred for 8 h under reflux. Addition of 2N aqueous NaOH, extraction with CH 2 Cl 2 , washing of the organic layers with saturated NaHCO 3 solution and saturated NaCl solution and evaporation of the solvent gave a residue that was treated with iPrOH/HCl after which the product precipitated. After filtration a white salt (134 mg, 39%) was obtained.
ESI-MS [M+H + ]=481 Calculated for C 24 H 30 ClFN 2 O 3 S=480
Example 159
N-(2-{[7-(Azetidin-1-yl)-8-(3-chloro-5-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide (2E)-but-2-enedioate









N-(2-{[7-(Azetidin-1-yl)-8-(3-chloro-5-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide (2E)-but-2-enedioate was synthesized in analogy to example 320.
ESI-MS [M+H + ]=507 C 26 H 32 ClFN 2 O 3 S=506
Example 160
N-(2-{[7-(Azetidin-1-yl)-8-(3-chloro-5-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide (2E)-but-2-enedioate









N-(2-{[7-(Azetidin-1-yl)-8-(3-chloro-5-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide (2E)-but-2-enedioate was synthesized in analogy to example 320.
ESI-MS [M+H + ]=533 C 26 H 30 ClFN 4 O 3 S=532
Example 161
1-Cyclopropyl-N-(2-{[8-(4-fluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)methanesulfonamide









The synthesis was performed starting from ethyl 7-(2-(cyclopropylmethylsulfonamido)-ethoxy)-1-(4-fluorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (synthesized in analogy to example 3), which was dissolved in THF (50 ml), after which LiAlH 4 was added at room temperature and the mixture was stirred for 8 h under reflux. Addition of 2N aqueous NaOH, extraction with CH 2 Cl 2 , washing of the organic layers with saturated NaHCO 3 solution and saturated NaCl solution and evaporation of the solvent gave a residue that was treated with iPrOH/HCl after which the product precipitated. After filtration a white salt (89 mg, 76%) was obtained.
ESI-MS [M+H + ]=447 C 24 H 31 FN 2 O 3 S=446
Example 162
(−)-N-(2-(8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









The synthesis was performed starting from (−)-ethyl 1-benzyl-7-(2-(cyclopropylmethyl-sulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (137), which was dissolved in THF (50 ml), after which LiAlH 4 was added at room temperature and the mixture was stirred for 8 h under reflux. Addition of 2N aqueous NaOH, extraction with CH 2 Cl 2 , washing of the organic layers with saturated NaHCO 3 solution and saturated NaCl solution and evaporation of the solvent gave a residue that was treated with iPrOH/HCl after which the product precipitated. After filtration a white salt (102 mg, 79%) was obtained. The racemate was separated by chiral chromatography on Chiracel AD (n-heptane/ethanol/tert-butanol 800:150:50) to deliver (after transfer to the salt form) (−)-N-(2-(8-benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride ([α]=−80.5° in MeOH, c=0.191 g/100 ml)
ESI-MS [M+H + ]=429 C 24 H 32 N 2 O 3 S=428
Example 163
1-Methyl-N-(2-{[8-(3-methylbenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1H-imidazole-4-sulfonamide









1-Methyl-N-(2-{[8-(3-methylbenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1H-imidazole-4-sulfonamide was synthesized in analogy to 264/88. ESI-MS [M+H + ]=509 C 28 H 36 N 4 O 3 S=508
Example 164
N-(2-{[8-(3-Methoxybenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









N-(2-{[8-(3-Methoxybenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride was synthesized in analogy to examples 264/88.
ESI-MS [M+H + ]=525 C 28 H 36 N 4 O 4 S=524
Example 165
1-Methyl-1H-imidazole-4-sulfonic acid {2-[7-amino-8-(3-trifluoromethyl-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









1-Methyl-1H-imidazole-4-sulfonic acid {2-[7-amino-8-(3-trifluoromethyl-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride was synthesized in analogy to example 3.
ESI-MS [M+H + ]=509 C 24 H 27 F 3 N 4 O 3 S=508
The following examples were prepared in analogy to example 40:
Example 166
N-{[7-Amino-8-(3-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=407 Calculated for C 21 H 27 ClN 2 O 2 S=406
Example 167
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-ylmethyl]methanesulfonamide hydrochloride









ESI-MS [M+H + ]=345 Calculated for C 19 H 24 N 2 O 2 S=344
Example 168
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]benzenesulfonamide hydrochloride









ESI-MS [M+H + ]=407 Calculated for C 24 H 26 N 2 O 2 S=406
Example 169
Enantiomer 2 of N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









The compound was obtained by chiral chromatography (Chiralpak AD-H 30 mm ID×250 mm, n-hexane/EtOH/MeOH/diethylamine=20/40/40/0.1) from the racemic compound (example 42) as the first eluting peak. Optical rotation=−50° (589 nm, 25° C., c=0.1 in methanol).
ESI-MS [M+H + ]=373 Calculated for C 21 H 28 N 2 O 2 S=372
Example 170
Enantiomer 1 of N-{[7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









The compound was obtained by chiral chromatography (Chiralpak AD-H 30 mm ID×250 mm, n-hexane/EtOH/MeOH/diethylamine=20/40/40/0.1) from the racemic compound (example 42) as the second eluting peak. Optical rotation=+49° (589 nm, 25° C., c=0.1 in methanol).
ESI-MS [M+H + ]=373 Calculated for C 21 H 28 N 2 O 2 S=372
Example 171
N-{[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=391 Calculated for C 21 H 27 FN 2 O 2 S=390
Example 172
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride









ESI-MS [M+H + ]411 Calculated for C 22 H 26 N 4 O 2 S=410
Example 173
N-[(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









ESI-MS [M+H + ]411 Calculated for C 22 H 26 N 4 O 2 S=410
Example 174
N-{[7-Amino-8-(4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}cyclobutanesulfonamide hydrochloride









ESI-MS [M+H + ]=403 Calculated for C 22 H 27 FN 2 O 2 S=402
Example 175
N-{[7-Amino-8-(4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=391 Calculated for C 21 H 27 FN 2 O 2 S=390
Example 176
N-{[7-Amino-8-(4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









ESI-MS [M+H + ]=429 Calculated for C 22 H 25 FN 4 O 2 S=428
Example 177
N-{[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









ESI-MS [M+H + ]=429 Calculated for C 22 H 25 FN 4 O 2 S=428
Example 178
N-{[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrazole-4-sulfonamide hydrochloride









ESI-MS [M+H + ]=429 Calculated for C 22 H 25 FN 4 O 2 S=428
Example 179
N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-3-methylbenzenesulfonamide hydrochloride









ESI-MS [M+H + ]=421 Calculated for C 25 H 28 N 2 O 2 S=420
Example 180
N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrrole-3-sulfonamide hydrochloride









ESI-MS [M+H + ]=410 Calculated for C 23 H 27 N 3 O 2 S=409
Example 181
N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}pyridine-3-sulfonamide dihydrochloride









ESI-MS [M+H + ]=408 Calculated for C 23 H 25 N 3 O 2 S=407
Example 182
N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonamide hydrochloride









ESI-MS [M+H + ]=479 Calculated for C 23 H 25 F 3 N 4 O 2 S=478
Example 183
N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrazole-3-sulfonamide hydrochloride









Example 184
N-{[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}cyclobutanesulfonamide hydrochloride









ESI-MS [M+H + ]=403 Calculated for C 22 H 27 FN 2 O 2 S=402
Example 185
N-{[7-Amino-8-(3,4-difluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-cyclopropylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=421 Calculated for C 22 H 26 F 2 N 2 O 2 S=420
Example 186
N-{[7-Amino-8-(3,4-difluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}cyclobutanesulfonamide hydrochloride









ESI-MS [M+H + ]=421 Calculated for C 22 H 26 F 2 N 2 O 2 S=420
Example 187
N-{[8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









tert-Butyl [1-benzyl-7-{[(propylsulfonyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate prepared in analogy to example 39 (1240 mg, 2.62 mmol) was dissolved in tetrahydrofuran (50 mL). A solution of lithium aluminium hydride (1 M in tetrahydrofuran, 7.87 mL, 7.87 mmol) was added dropwise at room temperature. The reaction mixture was then heated to 60° C. for 1 h. Aqueous work-up, purification of the extracted product by flash chromatography (silica gel, dichloromethane, methanol) and treatment with 1.25 M hydrochloric acid in ethanol followed by concentration in vacuo gave the desired product. Yield: 590 mg (1.4 mmol, 53%).
ESI-MS [M+H + ]=425 Calculated for C 22 H 30 N 2 O 2 S=424
In analogy to example 187 the following examples were prepared:
Example 188
N-{[8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}cyclobutanesulfonamide hydrochloride









ESI-MS [M+H + ]=400 Calculated for C 23 H 30 N 2 O 2 S=399
Example 189
N-{[8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-3-methylbenzenesulfonamide hydrochloride









ESI-MS [M+H + ]=435 Calculated for C 26 H 30 N 2 O 2 S=434
Example 190
N-{[8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrrole-3-sulfonamide hydrochloride









ESI-MS [M+H + ]=424 Calculated for C 24 H 29 N 3 O 2 S=423
Example 191
N-{[8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrazole-3-sulfonamide hydrochloride









ESI-MS [M+H + ]=425 Calculated for C 23 H 28 N 4 O 2 S=424
Example 192
Enantiomer 1 of N-{[8-benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









A chiral building block, i.e. an enantiomer of tert-butyl (1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate









was used for the synthesis.
tert-Butyl (1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate can be prepared in analogy to the dichloroderivative described in example 34. The cis-isomer can be separated into the enantiomers by chiral chromatography (Deicel, Chiralpak IC, 250×4,6 mm ID, 5μ, n-heptane/ethanol=1/9 with 0.1% triethylamine). The enantiomer eluting second was used in the syntheses described above.
ESI-MS [M+H + ]=387 Calculated for C 22 H 30 N 2 O 2 S=386
Example 193
Enantiomer 1 of N-{[8-benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}cyclobutanesulfonamide hydrochloride









The enantiomer of tert-butyl (1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate described in example 192 was as chiral building block for the synthesis. ESI-MS [M+H + ]=399 Calculated for C 23 H 30 N 2 O 2 S=398
Example 194
N-{[trans-8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









Prepared from the trans derivative obtained as a by-product in the recrystallization of









(cf. example 1).
ESI-MS [M+H + ]=387 Calculated for C 22 H 30 N 2 O 2 S=386
Example 195
N-{[8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









ESI-MS [M+H + ]=425 Calculated for C 23 H 28 N 4 O 2 S=424
Example 196
N-(1-Benzyl-7-{[(propylsulfonyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide









N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide (cf. example 42) was acetylated in dichloromethane with acetyl chloride in the presence of ethyldiisopropylamine at room temperature.
ESI-MS [M+H + ]=415 Calculated for C 23 H 30 N 2 O 3 S=414
Example 197
N-[(1-(4-Fluorobenzyl)-7-({[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}methyl)-1,2,3,4-tetrahydronaphthalen-2-yl]acetamide









This compound was prepared in analogy to example 196.
ESI-MS [M+H + ]=471 Calculated for C 24 H 27 FN 4 O 3 S=470
Example 198
N-{[8-Benzyl-7-(ethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride









N-(1-Benzyl-7-{[(propylsulfonyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide (example 196, 153 mg, 0.37 mmol) was dissolved in tetrahydrofuran (5 mL). 1 M Boran dimethylsulfide complex solution in tetrahydrofuran (852 μL, 8.52 mmol) was added and the reaction mixture stirred at room temperature over night. Water was added and the mixture extracted with dichloromethane (three times). The combined organic extracts were dried (MgSO 4 ) and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Excess 6 M hydrochloric acid in isopropanol was added. The solvent was evaporated and the product dried in vacuo. Yield: 70 mg (0.16 mmol, 36%).
ESI-MS [M+H + ]=401 Calculated for C 23 H 32 N 2 O 2 S=400
The following examples were prepared in analogy to example 198:
Example 199
1-Methyl-1H-imidazole-4-sulfonic acid [7-ethylamino-8-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl]-amide hydrochloride









ESI-MS [M+H + ]=457 Calculated for C 24 H 29 FN 4 O 2 S=456
Example 200
1-Methyl-1H-pyrazole-4-sulfonic acid [7-ethylamino-8-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl]-amide hydrochloride









ESI-MS [M+H + ]=457 Calculated for C 24 H 29 FN 4 O 2 S=456
Example 201
N-{3-[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride
201.1 tert-Butyl [1-(4-chlorobenzyl)-7-{3-[(propylsulfonyl)amino]propyl}-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









To a solution of 9-BBN (0.5 M in tetrahydrofuran, 8.85 mL, 4.42 mmol) was added dropwise a solution N-allylpropane-1-sulfonamide (1152 mg, 7.06 mmol) in tetrahydrofuran (1 mL) a 0° C. After stirring at 0° C. to 5° C. for 3.5 hours dioxane (25 mL) was added followed by 7-(tert-butoxycarbonylamino)-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (1000 mg, 1.923 mmol, prepared analogously to example 34.3), palladium acetate (43.2 mg, 0.192 mmol), triphenylphosphine (101 mg, 0.385 mmol) and cesium carbonate (1253 mg, 3.85 mmol). The yellow reaction mixture was heated under reflux for 3 hours. The reaction mixture was diluted with ethyl acetate (60 mL) and washed with water (2×40 mL). The organic layer was dried and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloro methane, methanol). Yield: 854 mg (1.596 mmol, 83%).
201.2N-{3-[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









tert-Butyl [1-(4-chlorobenzyl)-7-{3-[(propylsulfonyl)amino]propyl}-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (150 mg, 0.281 mmol) was dissolved in dichloromethane (3 mL) and a solution of hydrochloric acid (0.5 mL, 5 M in isopropanol) was added. After stirring at room temperature for 2 hours the solvent was removed in vacuo. Water was added (15 mL) and the pH was adjusted to 9 with aqueous saturated sodium bicarbonate and the mixture was extracted with dichloromethane (3×15 mL). The combined organic extracts were dried and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). The product was dissolved in dichloromethane (2 mL) and a solution of hydrochloric acid in ethanol (1.25 M) was added. The solvent was removed in vacuo. Yield: 31.4 mg (0.187 mmol, 36%). ESI-MS [M+H + ]=435 Calculated for C 23 H 31 ClN 2 O 2 S=434
The following examples were prepared in analogy to example 201:
Example 202
N-{3-[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=447 Calculated for C 24 H 31 ClN 2 O 2 S=446
Example 203
N-{3-[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=469 Calculated for C 23 H 30 Cl 2 N 2 O 2 S=468
Example 204
N-{3-[7-Amino-8-(3,4-difluoro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]propyl}-C-cyclopropyl-methanesulfonamide hydrochloride









ESI-MS [M+H + ]=449 Calculated for C 24 H 30 F 2 N 2 O 2 S=448
Example 205
N-{3-[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=401 Calculated for C 23 H 32 N 2 O 2 S=400
Example 206
N-{3-[7-Amino-8-(3,4-difluoro-benzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=437 Calculated for C 23 H 30 F 2 N 2 O 2 S=436
Example 207
N-{3-[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide trifluoroacetate









ESI-MS [M+H + ]=413 Calculated for C 24 H 32 N 2 O 2 S=412
Example 208
N-{3-[7-Amino-8-(4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=431 Calculated for C 24 H 31 FN 2 O 2 S=430
Example 209
N-{3-[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=419 Calculated for C 23 H 31 FN 2 O 2 S=418
Example 210
N-{3-[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=431 Calculated for C 24 H 31 FN 2 O 2 S=430
Example 211
N-{3-[7-Amino-8-(2-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=435 Calculated for C 23 H 31 ClN 2 O 2 S=434
Example 212
N-{3-[7-Amino-8-(2-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]propyl}-C-cyclopropyl-methanesulfonamide hydrochloride









ESI-MS [M+H + ]=447 Calculated for C 24 H 31 ClN 2 O 2 S=446
Example 213
N-{3-[7-Amino-8-(4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=419 Calculated for C 23 H 31 FN 2 O 2 S=418
Example 214
N-[1-(3-Fluorobenzyl)-7-{3-[(propylsulfonyl)amino]propyl}-1,2,3,4-tetrahydronaphthalen-2-yl]acetamide









N-(3-(7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl)propyl)propane-1-sulfonamide (cf. example 209: 45 mg, 0.108 mmol) and triethylamine (15 μL, 0.108 mmol) were dissolved in dichloromethane (2 mL). Acetylchloride (7.64 μL, 0.108 mmol) were added. The reaction mixture was stirred for 12 hours at room temperature. The reaction mixture was diluted with dichloromethane and successively washed with hydrochloric acid, water and saturated sodium chloride solution. The organic layer was dried and concentrated in vacuo. The crude product was purified by flash-chromatography (silica gel, dichloromethane, methanol). Yield: 37 mg (0.08 mmol, 75%).
ESI-MS [M+H + ]=461 Calculated for C 25 H 33 FN 2 O 3 S=460
In analogy to example 214 the following examples were prepared:
Example 215
N-[1-(4-Fluorobenzyl)-7-{3-[(propylsulfonyl)amino]propyl}-1,2,3,4-tetrahydronaphthalen-2-yl]acetamide









ESI-MS [M+H + ]=461 Calculated for C 25 H 33 FN 2 O 3 S=460
Example 216
N-[1-Benzyl-7-(3-{[(cyclopropylmethyl)sulfonyl]amino}propyl)-1,2,3,4-tetrahydronaphthalen-2-yl]acetamide









ESI-MS [M+H + ]=455 Calculated for C 26 H 34 N 2 O 3 S=454
Example 217
N-[1-Benzyl-7-{3-[(propylsulfonyl)amino]propyl}-1,2,3,4-tetrahydronaphthalen-2-yl]acetamide









ESI-MS [M+H + ]=443 Calculated for C 25 H 34 N 2 O 3 S=442
Example 218
N-[7-(3-{[(Cyclopropylmethyl)sulfonyl]amino}propyl)-1-(3-fluorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]acetamide









ESI-MS [M+H + ]=473 Calculated for C 26 H 33 FN 2 O 3 S=472
Example 219
Propane-1-sulfonic acid {3-[7-ethylamino-8-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-propyl}-amide hydrochloride









N-(1-(3-Fluorobenzyl)-7-(3-(propylsulfonamido)propyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide (cf. example 214, 19.5 mg, 0.042 mmol) was dissolved in tetrahydrofuran (1 mL) and borane dimethylsulfide (106 μL, 0.212 mmol) was added. The reaction mixture was stirred for 5 hours at 50° C. After cooling to room temperature aqueous hydrochloric acid was added. The mixture was made alkaline by the addition of sodium bicarbonate and extracted several times with dichloromethane. The combined organic extracts were dried (MgSO 4 ), concentrated in vacuo and the crude product purified by flash-chromatography (silica gel, dichloromethane, methanol). An excess of 1 M hydrochloric acid in ether was added to the purified product and the ether distilled off. Yield: 7 mg (0.016 mmol, 37%).
ESI-MS [M+H + ]=447 Calculated for C 25 H 35 FN 2 O 2 S=446
The following examples were prepared in analogy to example 219:
Example 220
N-{3-[7-(Ethylamino)-8-(4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=447 Calculated for C 25 H 35 FN 2 O 2 S=446
Example 221
C-Cyclopropyl-N-{3-[7-ethylamino-8-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-propyl}-methanesulfonamide hydrochloride









ESI-MS [M+H + ]=459 Calculated for C 26 H 35 FN 2 O 2 S=458
Example 222
Propane-1-sulfonic acid {3-[8-(2-chloro-benzyl)-7-ethylamino-5,6,7,8-tetrahydro-naphthalen-2-yl]-propyl}-amide hydrochloride









ESI-MS [M+H + ]=463 Calculated for C 25 H 35 ClN 2 O 2 S=462
Example 223
N-{3-[8-Benzyl-7-(ethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=429 Calculated for C 25 H 36 N 2 O 2 S=428
Example 224
N-{3-[8-Benzyl-7-(ethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=441 Calculated for C 26 H 36 N 2 O 2 S=440
Example 225
N-{3-[8-(3,4-Difluorobenzyl)-7-(ethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide trifluoroacetate









ESI-MS [M+H + ]=465 Calculated for C 26 H 34 F 2 N 2 O 2 S=464
Example 226
1-Cyclopropyl-N-{3-[8-(3,4-difluorobenzyl)-7-(ethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}methanesulfonamide trifluoroacetate









ESI-MS [M+H + ]=477 Calculated for C 26 H 34 F 2 N 2 O 2 S=476
Example 227
N-{3-[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-N-methylpropane-1-sulfonamide hydrochloride









tert-Butyl (1-(3-fluorobenzyl)-7-(3-(propylsulfonamido)propyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (cf. 209 and 201a, 65 mg, 0.125 mmol) was dissolved in acetonitrile (800 μL) and methyl iodide (24 μL, 0.376 mmol) and cesium carbonate (0.102 g, 0.313 mmol) was added. The reaction mixture was heated for 24 hours in a sealed vessel to 80° C. The reaction mixture was diluted with ethyl acetate. The ethyl acetate solution was successively washed with water and saturated sodium chloride solution. The organic phase was dried (MgSO 4 ) and concentrated in vacuo. The crude product was purified by preparative thin-layer chromatography (silica gel, dichloromethane, methanol). The obtained tert-butyl 1-(3-fluorobenzyl)-7-(3-(N-methylpropylsulfonamido)propyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (65 mg, 0.122 mmol) was dissolved in 4 M hydrochloric acid in isopropanol and stirred at room temperature for 4 hours. The solvent was removed in vacuo. Diethyl ether was added and the precipitate removed by filtration and dried. Yield: 22 mg (0.047 mmol, 38%).
ESI-MS [M+H + ]=433 Calculated for C 24 H 33 FN 2 O 2 S=432
The following examples were prepared in analogy to example 227:
Example 228
N-{3-[7-Amino-8-(2-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]propyl}-C-cyclopropyl-N-methyl-methanesulfonamide hydrochloride









ESI-MS [M+H + ]=461 Calculated for C 25 H 33 ClN 2 O 2 S=460
Example 229
Propane-1-sulfonic acid {3-[7-amino-8-(2-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-propyl}-methyl-amide hydrochloride









ESI-MS [M+H + ]=449 Calculated for C 24 H 33 ClN 2 O 2 S=448
Example 230
N-{3-[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropyl-N-methylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=445 Calculated for C 25 H 33 FN 2 O 2 S=444
Example 231
N-{3-[7-Amino-8-(4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropyl-N-methylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=445 Calculated for C 25 H 33 FN 2 O 2 S=444
Example 232
N-{3-[7-Amino-8-(4-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-N-methylpropane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=433 Calculated for C 24 H 33 FN 2 O 2 S=432
Example 233
N-{3-[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropyl-N-methylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=461 Calculated for C 25 H 33 ClN 2 O 2 S=460
Example 234
N-{3-[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-N-methylpropane-1-sulfonamide hydrochloride









ESI-MS [M+H + ]=449 Calculated for C 24 H 33 ClN 2 O 2 S=448
Example 235 was Prepared in Analogy to Example 47
N-(2-{[7-Amino-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-cyclopropylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=433 Calculated for C 23 H 29 FN 2 O 3 S=432
The following examples were prepared in analogy to example 46:
Example 236
Ethyl [1-(3,5-difluorobenzyl)-7-(2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}ethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









ESI-MS [M+H + ]=548 Calculated for C 27 H 31 F 2 N 3 O 5 S=547
Example 237
Ethyl [7-(2-{[(cyclopropylmethyl)sulfonyl]amino}ethoxy)-1-(3,5-difluorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









ESI-MS [M+H + ]=523 Calculated for C 26 H 32 F 2 N 2 O 5 S=522
Example 238 was Prepared in Analogy to Example 47
Enantiomer 1 of N-(2-{[7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









Could be separated by chiral chromatography of the final compound or an intermediate. ESI-MS [M+H + ]=441 Calculated for C 23 H 28 N 4 O 3 S=440
The following examples were prepared in analogy to example 137:
Example 239
Enantiomer 2 of C-cyclopropyl-N-{2-[8-(3-fluoro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-methanesulfonamide hydrochloride









C-Cyclopropyl-N-{2-[8-(3-fluoro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-methanesulfonamide (Daicel, Chiralpak IC, 250×4,6 mm ID, 5μ, methyl t-butyl ether/dichloromethane/methanol/triethylamine=900/50/50/1). The second eluting enantiomer was used for synthesis of the final compound.
ESI-MS [M+H + ]=447 Calculated for C 24 H 31 FN 2 O 3 S=446
Example 240
Enantiomer 1 of 1-cyclopropyl-N-(2-{[8-(3-fluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)methanesulfonamide hydrochloride









Ethyl 7-(2-(cyclopropylmethylsulfonamido)ethoxy)-1-(3-fluorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate was separated by chiral chromatography (Daicel, Chiralpak IC, 250×4,6 mm ID, methyl t-butyl ether/dichloromethane/methanol/triethylamine=900/50/50/1). The first eluting enantiomer was used for synthesis of the final compound. ESI-MS [M+H + ]=447 Calculated for C 24 H 31 FN 2 O 3 S=446
Example 241
Enantiomer 1 of N-(2-{[8-(3,5-difluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide hydrochloride









Ethyl 1-(3,5-difluorobenzyl)-7-(2-(1-methyl-1H-pyrrole-3-sulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate was separated by chiral chromatography (Daicel, Chiralpak AD, 250×20 mm ID, 10μ, n-heptane/ethanol/triethylamine=35/65/1). The second eluting enantiomer was used for synthesis of the final compound. Can be separated by chiral chromatography of the final compound or an intermediate. ESI-MS [M+H + ]=490 Calculated for C 25 H 29 F 2 N 3 O 3 S=489
Example 242
Enantiomer 2 of N-(2-{[8-(3,5-difluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide hydrochloride









Ethyl 1-(3,5-difluorobenzyl)-7-(2-(1-methyl-1H-pyrrole-3-sulfonamido)ethoxy)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate was separated by chiral chromatography (Deicel, Chiralpak AD, 250×20 mm ID, 10μ, n-heptane/ethanol/triethylamine=35/65/1). The first eluting enantiomer was used for synthesis of the final compound.
ESI-MS [M+H + ]=490 Calculated for C 25 H 29 F 2 N 3 O 3 S=489
Example 243
1-Cyclopropyl-N-(2-{[8-(3,5-difluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)methanesulfonamide hydrochloride









ESI-MS [M+H + ]=465 Calculated for C 24 H 30 F 2 N 2 O 3 S=464
Example 244
Enantiomer 2 of 1-cyclopropyl-N-(2-{[8-(3,5-difluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethylmethanesulfonamide hydrochloride









Ethyl 7-(2-(cyclopropylmethylsulfonamido)ethoxy)-1-(3,5-difluorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate was separated by chiral chromatography (Daicel, Chiralpak AD, 250×20 mm ID, 10μ, n-heptane/ethanol/t-butanol=800/150/50). The first eluting enantiomer was used for synthesis of the final compound.
ESI-MS [M+H + ]=465 Calculated for C 24 H 30 F 2 N 2 O 3 S=464
Example 245
Enantiomer 1 of 1-cyclopropyl-N-(2-{[8-(3,5-difluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)methanesulfonamide hydrochloride









Ethyl 7-(2-(cyclopropylmethylsulfonamido)ethoxy)-1-(3,5-difluorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate was separated by chiral chromatography (Daicel, Chiralpak AD, 250×20 mm ID, 10μ, n-heptane/ethanol/t-butanol=800/150/50). The second eluting enantiomer was used for synthesis of the final compound.
ESI-MS [M+H + ]=465 Calculated for C 24 H 30 F 2 N 2 O 3 S=464
Example 246
N-(2-{[8-(3,5-Difluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide hydrochloride









ESI-MS [M+H + ]=490 Calculated for C 25 H 29 F 2 N 3 O 3 S=489
Example 247
1-Cyclopropyl-N-(2-{[8-(3-fluorobenzyl)-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)methanesulfonamide hydrochloride









ESI-MS [M+H + ]=447 Calculated for C 24 H 31 FN 2 O 3 S=446
Example 248
N-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide
248.1 7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalene-2-carbonitrile









Tert-butyl 1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1.1 g, 3.03 mmol) was dissolved in dichloromethane (20 mL) and 5 M hydrochloric acid in isopropanol (2 mL) was added. The reaction mixture was stirred at room temperature for 12 h followed by 4 h at 35° C. The solvent was evaporated in vacuo. Water (30 mL) was added and the pH was adjusted to pH 9 using aqueous saturated sodium bicarbonate solution. The aqueous layer was extracted with dichloromethane. The combined extracts were dried (MgSO 4 ) and the solvent was evaporated in vacuo. Yield: 790 mg (3.03 mmol, 100%).
248.2 7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalene-2-carbonitrile









7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalene-2-carbonitrile (790 mg, 3.03 mmol), 1,3-dibromopropane (0.4 mL, 3.93 mmol) and triethylamine (0.914 mL, 6.56 mmol) were dissolved in acetonitrile (8 mL) and the reaction mixture heated to 120° C. in the microwave for 2 h. The solvent was evaporated in vacuo. Water (30 mL) and ethyl acetate (40 mL) were added. The layers were separated and the aqueous layer extracted with ethyl acetate. The combined organic extracts were dried (MgSO 4 ) and the solvent evaporated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 346 mg (1.14 mmol, 37.6%).
248.3 1-[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methanamine









7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalene-2-carbonitrile (340 mg, 1.12 mmol) was dissolved in dry methanol (20 mL) under a nitrogen atmosphere. Raney nickel (900 mg, 3.36 mmol) was added under nitrogen and the reaction mixture stirred at room temperature for 48 h under an atmosphere of hydrogen. Methanol (20 mL) and dichloromethane (30 mL) were added. After stirring at room temperature for 20 minutes the catalyst was removed by filtration and the solvent evaporated in vacuo. Yield: 338 mg (1.10 mmol, 98%).
248.4 N-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide









(7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methanamine (250 mg, 0.816 mmol) and N,N-dimethyl-4-aminopyridine (199 mg, 1.632 mmol) were dissolved in dichloromethane (18 mL). 1-Methyl-1H-imidazole-4-sulfonyl chloride (147 mg, 0.816 mmol) dissolved in dichloromethane (2 mL) was added dropwise. The reaction mixture was stirred at room temperature for 12 h. The reaction mixture was diluted with dichloromethane (20 mL) and washed successively with saturated ammonium chloride (3×15 mL) and water (2×10 mL). The organic phase was dried (MgSO 4 ) and the solvent was evaporated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 64 mg (0.142 mmol, 17%).
ESI-MS [M+H + ]=451 Calculated for C 25 H 30 N 4 O 2 S=450
The following examples were prepared in analogy to 248:
Example 249
N-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide









ESI-MS [M+H + ]=413 Calculated for C 24 H 32 N 2 O 2 S=412
Example 250
N-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrazole-4-sulfonamide









ESI-MS [M+H + ]=451 Calculated for C 25 H 30 N 4 O 2 S=450
Example 251
N-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrrole-3-sulfonamide trifluoroacetate









ESI-MS [M+H + ]=450 Calculated for C 26 H 31 N 3 O 2 S=449
Example 252
Enantiomer 1 of N-{[7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide









The enantiomer of tert-butyl (1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate described in example 192 was used as chiral building block for the synthesis.
ESI-MS [M+H + ]=451 Calculated for C 26 H 30 N 4 O 2 S=450
Example 253
Enantiomer 1 of N-{[7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}pyridine-2-sulfonamide









The enantiomer of tert-butyl (1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate described in example 192 was used as chiral building block for the synthesis.
ESI-MS [M+H + ]=448 Calculated for C 26 H 29 N 3 O 2 S=447
Example 254
Enantiomer 1 of N-{[7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrazole-4-sulfonamide









The enantiomer of tert-butyl (1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate described in example 192 was as chiral building block for the synthesis. ESI-MS [M+H + ]=451 Calculated for C 25 H 30 N 4 O 2 S=450
Example 255
Enantiomer 1 of N-{[7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}thiophene-2-sulfonamide









The enantiomer of tert-butyl (1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate described in example 192 was used as chiral building block for the synthesis.
ESI-MS [M+H + ]=453 Calculated for C 25 H 28 N 2 O 2 S 2 =452
Example 256
N-{[7-(Azetidin-1-yl)-8-(3-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide hydrochloride









ESI-MS [M+H + ]=469 Calculated for C 25 H 29 FN 4 O 2 S=468
Example 257
N-{[8-Benzyl-7-(morpholin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide









This compound was prepared in analogy to example 248 using 1-bromo-2-(2-bromoethoxy)ethane in place of 1,3-dibromopropane.
ESI-MS [M+H + ]=481 Calculated for C 26 H 32 N 4 O 3 S=480
The following examples were prepared in analogy to 257:
Example 258
N-{[8-Benzyl-7-(morpholin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-pyrazole-4-sulfonamide









ESI-MS [M+H + ]=481 Calculated for C 26 H 32 N 4 O 3 S=480
Example 259
N-{[8-Benzyl-7-(morpholin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-cyclopropylmethanesulfonamide









ESI-MS [M+H + ]=455 Calculated for C 26 H 34 N 2 O 3 S=454
Example 260
N-{[8-Benzyl-7-(morpholin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide









ESI-MS [M+H + ]=443 Calculated for C 25 H 34 N 2 O 3 S=442
Example 261
N-{[8-Benzyl-7-(morpholin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}cyclobutanesulfonamide









ESI-MS [M+H + ]=455 Calculated for C 26 H 34 N 2 O 3 S=454
Example 262
N-{[8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide









This compound was prepared in analogy to example 248 using 1,4-dibromobutane in place of 1,3-dibromopropane.
ESI-MS [M+H + ]=465 Calculated for C 26 H 32 N 4 O 2 S=464
Example 263
N-{[8-Benzyl-7-(2-oxopyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide









N-((7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-ylmethyl)-1-methyl-1H-imidazole-4-sulfonamide (271 mg, 0.66 mmol, cf. 173) was dissolved in dichloromethane (10 mL). Pyridine (0.191 mL, 2.357 mmol) was added. 4-Chlorobutanoyl chloride (0.116 mL, 1.038 mmol) was added dropwise. After 2 h N,N-dimethyl-4-aminopyridine (46 mg, 0.378 mmol) was added and stirring was continued over night. 1 N sodium hydroxide solution was added and the mixture extracted with dichloromethane. The combined organic extracts were dried (MgSO 4 ) and concentrated in vacuo. The crude product was suspended in dry tetrahydrofuran and a suspension of sodium hydride (60% in oil, 179 mg, washed twice with pentane prior to addition) in tetrahydrofuran (3 mL) was added. The reaction mixture was heated to 45° C. for 1 h. Water was added and the mixture was extracted with dichloromethane (3×20 mL). The combined organic extracts were dried (MgSO 4 ) and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 98 mg (0.205 mmol, 46%).
ESI-MS [M+H + ]=479 Calculated for C 26 H 30 N 4 O 3 S=478
Example 264
N-{3-[8-(3-Chlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride
264.1 1-[1-(3-Chlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]pyrrolidine









1-(3-Chlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (6 g, 19.88 mmol) was dissolved in acetonitrile (150 mL). 1,4-Dibromobutane (2.61 mL, 21.87 mmol) and triethylamine (6.1 mL, 43.7 mmol) were added and the reaction mixture heated under reflux for 3 h. The reaction mixture was poured on ice and extracted with dichloromethane. The combined organic extracts were successively washed with water and brine, dried (MgSO 4 ) and the solvent was evaporated in vacuo. The crude product (6.6 g) was used for the next step without further purification.
264.2 8-(3-Chlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol









1-(1-(3-Chlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)pyrrolidine (6.6 g, 18.54 mmol) was dissolved in dichloromethane (100 mL). A 1 M solution of bortribromide in dichloromethane (55.6 mL, 55.6 mmol) was added dropwise under cooling maintaining the reaction mixture at room temperature. The reaction mixture was stirred at room temperature for 2 h. The reaction was poured on ice, made alkaline with sodium hydroxide. The aqueous phase was extracted with ethyl acetate and the combined organic extracts were washed successively with sodium bicarbonate and brine. The combined extracts were dried (MgSO 4 ) and the solvent was evaporated in vacuo. The crude product (5.5 g) was used for the next step without further purification.
264.3 8-(3-Chlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate









8-(3-Chlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol (5.5 g, 16.09 mmol) was dissolved in dichloromethane (150 mL). 1,1,1-trifluoro-N-phenyl-N-(trifluoromethylsulfonyl)methanesulfonamide (6.9 g, 19.31 mmol) was added at 0° C. followed by the addition of a solution of triethylamine (4.48 mL, 32.2 mmol) in dichloromethane (50 mL). The reaction mixture was allowed to warm to room temperature and stirring was continued over night. The reaction was poured on ice and extracted with dichloromethane. The combined extracts were washed successively with ammonium chloride solution, water and brine. The extracts were dried (Na 2 SO 4 ) and the solvent was evaporated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 6.33 g (13.36 mmol, 83%).
264.4 N-{3-[8-(3-Chlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









N-allylpropane-1-sulfonamide (0.238 g, 1.456 mmol) is added to a solution of 9-borabicyclo[3.3.1]nonane (0.185 g, 1.519 mmol) in tetrahydrofuran (4 mL). The reaction mixture was stirred for 2 h at room temperature. (7R,8S)-8-(3-chlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (0.3 g, 0.633 mmol) dissolved in tetrahydrofuran (2 mL), sodium hydroxide (0.063 g, 1.582 mmol in 0.06 mL water) and palladium tetrakistriphenylphosphine (0.073 g, 0.063 mmol) were added. The reaction mixture was heated under reflux over night. The reaction mixture was diluted with ethyl acetate and washed with 1 M sodium hydroxide solution. The aqueous phase was extracted two more times with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO 4 ) and the solvent was evaporated in vacuo. The crude product was purified by preparative thin-layer-chromatography (silica gel, dichloromethane, methanol). The product was dissolved in dichloromethane. Excess 5N hydrochloric acid in ethanol was added. The solvent was evaporated and the product dried in vacuo. Yield: 53 mg (0.108 mmol, 17%).
ESI-MS [M+H + ]=489 Calculated for C 27 H 37 ClN 2 O 2 S=488
The following examples were prepared in analogy to 264:
Example 265
Propane-1-sulfonic acid [3-(8-benzyl-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propyl]-amide hydrochloride









ESI-MS [M+H + ]=455 Calculated for C 27 H 38 N 2 O 2 S=454
Example 266
N-{3-[8-Benzyl-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide hydrochloride









ESI-MS [M+H + ]=467 Calculated for C 28 H 38 N 2 O 2 S=466
Example 267
N-(2-{[8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide
267.1 8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol









8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol was prepared in analogy to 8-(3-chlorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol (cf. 264).
267.2 2-{[8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethanamine









2-{[8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethanamine was prepared in analogy to example 1 and 2 from 8-(3-fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-ol.
267.3 N-(2-{[8-(3-fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide









2-(8-(3-Fluorobenzyl)-7-(pyrrolidin-1-yl)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethanamine (50 mg, 0.136 mmol) was dissolved in dichloromethane (2 mL). N,N-Dimethyl-4-aminopyridine (49.7 mg, 0.407 mmol) and 1-methyl-1H-pyrrole-3-sulfonyl chloride (24.4 mg, 0.136 mmol) were added successively. The reaction mixture was stirred at room temperature over night. The reaction was diluted with dichloromethane and washed with water. The organic phase was dried (MgSO 4 ) and the solvent was evaporated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 31 mg (0.061 mmol, 45%).
ESI-MS [M+H + ]=512 Calculated for C 28 H 34 FN 3 O 3 S=511
The following examples were prepared in analogy to 267:
Example 268
N-(2-{[7-(Azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide









ESI-MS [M+H + ]=480 Calculated for C 27 H 33 N 3 O 3 S=479
Example 269
1-Methyl-1H-pyrrole-3-sulfonic acid {2-[7-azetidin-1-yl-8-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide









ESI-MS [M+H + ]=498 Calculated for C 27 H 32 FN 3 O 3 S=497
Example 270
Enantiomer 1 of N-{1-benzyl-7-[2-(1-methyl-1H-imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-propionamide









N-{1-Benzyl-7-[2-(1-methyl-1H-imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-propionamide was prepared in analogy to example 2 using propionyl chloride in place of ethyl chloroformate.
Could be separated by chiral chromatography of the final compound or an intermediate. ESI-MS [M+H + ]=497 Calculated for C 26 H 32 N 4 O 4 S=496
Example 271
N-(2-{[8-(3,5-Difluorobenzyl)-7-(formylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide
271.1 Ethyl [1-(3,5-difluorobenzyl)-7-(2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}ethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate









Ethyl[1-(3,5-difluorobenzyl)-7-(2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}ethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate was prepared in analogy to example 2.
271.2 N-(2-{[8-(3,5-Difluorobenzyl)-7-(formylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-pyrrole-3-sulfonamide









Ethyl[1-(3,5-difluorobenzyl)-7-(2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}ethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (200 mg, 0.365 mmol) was dissolved in tetrahydrofuran (16 mL). A 1 M solution of lithium aluminium hydride in tetrahydrofuran (0.73 mL, 0.73 mmol) was added dropwise at room temperature. The reaction mixture was heated to 50° C. for 2 h. Under cooling 2N sodium hydroxide solution (3 mL) was added dropwise. Water (30 mL) and ethyl acetate (30 mL) were added. The aqueous phase was extracted twice with ethyl acetate. The combined extracts were dried (MgSO 4 ) and the solvent was evaporated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 61 mg (0.116 mmol, 32%).
ESI-MS [M+H + ]=504 Calculated for C 25 H 27 F 2 N 3 O 4 S=503
Example 272
N-{3-[8-(3,4-Dichlorobenzyl)-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide
272.1 1-(3,4-Dichlorobenzyl)-7-methoxy-N-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-amine









1-(3,4-Dichlorobenzyl)-7-methoxy-N-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-amine was isolated as a minor by-product in the recrystallization of 1-(3,4-dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride from isopropanol.
272.2 N-{3-[8-(3,4-Dichlorobenzyl)-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide









N-{3-[8-(3,4-Dichlorobenzyl)-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide was prepared in analogy to example 264 using 1-(3,4-dichlorobenzyl)-7-methoxy-N-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-amine in place of 1-[1-(3-chlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]pyrrolidine. ESI-MS [M+H + ]=511 Calculated for C 25 H 32 Cl 2 N 2 O 3 S=510
Example 273
N-{3-[8-Benzyl-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide hydrochloride









N-{3-[8-(3,4-Dichlorobenzyl)-7-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}propane-1-sulfonamide (70 mg, 0.137 mmol) was dissolved in methanol (1.5 mL) and palladium hydroxide (30 mg, 0.214 mmol) was added. The reaction mixture was heated under reflux in an atmosphere of hydrogen for 6 h. The catalyst was removed by filtration and the crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). The obtained amine was dissolved in dichloromethane (2 mL) and 5 N hydrochloric acid in isopropanol (0.3 mL) was added. The solvent was evaporated and the product dried in vacuo. Yield: 30 mg (0.63 mmol, 46%).
ESI-MS [M+H + ]=443 Calculated for C 26 H 38 N 2 O 2 S=442
Example 274
N-{3-[8-(4-Chlorobenzyl)-7-(diethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide hydrochloride
274.1 N-{3-[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide









N-{3-[7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide (cf. 202).
274.2 N-{3-[8-(4-Chlorobenzyl)-7-(diethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]propyl}-1-cyclopropylmethanesulfonamide hydrochloride









N-(3-(7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl)propyl)-1-cyclopropylmethanesulfonamide (49 mg, 0.11 mmol) was dissolved in dichloromethane (2 mL). Acetic acid (7 μL, 0.11 mmol) was added followed by acetaldehyde (18 μL, 0.322 mmol) in dichloromethane (2 mL) and sodium triacetoxyborohydride (34 mg, 0.16 mmol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with dichloromethane (20 mL) and washed with water (2×10 mL). The organic layer was dried (MgSO 4 ) and the solvent was evaporated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). The amine was dissolved in dichloromethane (3 mL) and excess hydrochloric acid in ethanol was added. The solvents were evaporated and the product dried in vacuo. Yield: 22 mg (0.041 mmol, 38%).
ESI-MS [M+H + ]=503 Calculated for C 28 H 39 ClN 2 O 2 S=502
Example 275
N-{[8-Benzyl-7-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-N-methylpropane-1-sulfonamide trifluoroacetate









This compound could be prepared in analogy to example 227 using tert-butyl [(1S,2R)-1-benzyl-7-{[(propylsulfonyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate in place of tert-butyl 1-(3-fluorobenzyl)-7-(3-(propylsulfonamido)propyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (alkylation of sulfonamide). The tert-butyl carbamate could then be reduced with lithium aluminium hydride as in example 187.
ESI-MS [M+H + ]=401 Calculated for C 23 H 32 N 2 O 2 S=400
Example 276
N-[1-Benzyl-7-{3-[(propylsulfonyl)amino]prop-1-yn-1-yl}-1,2,3,4-tetrahydronaphthalen-2-yl]acetamide









7-Acetamido-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (100 mg, 0.234 mmol; prepared in analogy to 8-(3,4-dichlorobenzyl)-7-[(ethoxycarbonyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate, example 29), N-(prop-2-ynyl)propane-1-sulfonamide (75 mg, 0.468 mmol), palladium tetrakistriphenylphosphine (54 mg, 0.047 mmol), copper(I) iodide (35.6 mg, 0.187 mmol) and triethylamine (65 μL, 0.468 mmol) in dioxane (3 mL) were heated under reflux for 16 h. Water (15 mL) was added and the mixture extracted with dichloromethane (3×20 mL). The combined organic extracts were dried (MgSO 4 ) and the solvent was evaporated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 56 mg (0.132 mmol, 57%).
ESI-MS [M+H + ]=439 Calculated for C 25 H 30 N 2 O 3 S=438
Example 277
N-(2-(8-Benzyl-7-(oxetan-3-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-cyclopropylmethanesulfonamide









N-(2-(7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)ethyl)-1-cyclopropylmethanesulfonamide (50 mg, 0.121 mmol) was dissolved in methanol. Oxetan-3-one (87 mg, 1.21 mmol), zinc chloride (66 mg, 0.482 mmol) and sodium cyanoborohydride (23 mg, 0.362 mmol) were added at 0° C. The reaction mixture was then heated to 40° C. for 5 h. Aqueous ammonium chloride solution was added and the aqueous layer was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO 4 ) and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, dichloromethane, methanol). Yield: 3 mg (6.4 μmol, 5%).
ESI-MS [M+H + ]=471 Calculated for C 26 H 34 N 2 O 4 S=470
Example 278
Propane-1-sulfonic acid (8-benzyl-7-cyclopropylamino-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-amide hydrochloride









N-((7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)propane-1-sulfonamide (51 mg, 0.137 mmol), (1-ethoxycyclopropoxy)trimethylsilane (26 mg, 0.151 mmol), acetic acid (0.078 mL, 1.37 mmol), sodium cyanoborohydride (26 mg, 0.411 mmol) and molecular sieve (50 mg) in methanol (1.5 mL) were heated in the microwave at 100° C. for 25 min. The solvent was evaporated and the crude product purified by flash chromatography (silica gel, dichloromethane, methanol) and converted into the hydro chloride. Yield: 18 mg (0.04 mmol, 29%).
ESI-MS [M+H + ]=413 Calculated for C 24 H 32 N 2 O 2 S=412
Example 279
(1-(4-Chloro-benzyl)-7-{2-[methyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester
279.1 Propane-1-Sulfonic Acid Cyclopropyl Amide









To a solution of cyclopropylamine (1.2 ml, 17.5 mmol) in 100 ml CH 2 Cl 2 and DMAP (2.4 g, 17.5 mmol) was added dropwise a solution of propane-1-sulfonyl chloride (2.3 ml, 19.2 mmol) in 50 ml CH 2 Cl 2 . The resulting mixture was stirred at room temperature over night and diluted with 50 ml of CH 2 Cl 2 . The mixture was extracted subsequently with water, 1 M HCl, and brine, tried over Na 2 SO 4 , filtered and the solvent evaporated to obtain 2.8 g of product (oil) which was used in the next step without further purification.
279.2 Acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester









A mixture of propane-1-sulfonic acid cyclopropyl amide (1.3 g, 8 mmol), K2CO3 (2.4 g, 14.4 mmol) and acetic acid 2-bromo-ethyl ester (9.5 g, 16 mmol) mmol) in 10 ml acetone was heated for 6 h to 120° C. in the microwave (Biotage). After cooling the mixture was filtered and the solvent evaporated to obtain 1.7 g of product as an oil which was used without further purification in the next step.
279.3 Propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide









A mixture of acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester (1.7 g, 6.8 mmol) and KOH (0.57 g, 10.2 mmol) in 30 ml Methanol was stirred over night at room temperature. The solvent was evaporated the residue dissolved in ethyl acetate and subsequently extracted with water and 1 M KOH, dried over Na 2 SO 4 and the solvent evaporated to obtain 0.46 g of product which was used purified by chromatography (253.5 mg of colorless oil)
279.4 Propane-1-sulfonic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester









To a solution of propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide (150 mg, 0.8 mmol) in CH 2 Cl 2 and DMAP (97 mg, 0.8 mmol) was added dropwise a solution of propane-1-sulfonyl chloride (97 mg, 0.8 mmol) in CH 2 Cl 2 . The resulting mixture was stirred at room temperature over night, diluted with 50 ml of CH 2 Cl 2 , extracted subsequently with water, 1 M HCl, and brine, tried over Na 2 SO 4 , filtered and the solvent evaporated to obtain 197.5 mg of product which was used in the next step without further purification.
279.5 1-(3-Chloro-benzyl)-7-{2-[cyclopropyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester









Prepared in one step from ethyl 1-(3-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (prepared in analogy to example 1d) and propane-1-sulfonic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester in analogy to example 76.
ESI-MS [M+H + ]=549 Calculated for C 28 H 37 ClN 2 O 5 S=548
Example 280
1-Benzyl-7-{2-[cyclopropyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester









Prepared in one step from ethyl 1-benzyl-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (prepared in analogy to example 1d) and propane-1-sulfonic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]-ethyl ester in analogy to example 76. ESI-MS [M+H + ]=515 Calculated for C 28 H 38 N 2 O 5 S=514
Example 281
Propane-1-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-cyclopropyl-amide hydrochloride









Prepared in one step from 1-(3-Chloro-benzyl)-7-{2-[cyclopropyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester (example 279) example in analogy to example 3.
ESI-MS [M+H + ]=477 Calculated for C 25 H 33 ClN 2 O 3 S=476
Example 282
Propane-1-sulfonic acid [2-(7-amino-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-cyclopropyl-amide hydrochloride









Prepared in one step from 1-Benzyl-7-{2-[cyclopropyl-(propane-1-sulfonyl)-amino]-ethoxy}-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid ethyl ester (example 280) in analogy to example 3.
ESI-MS [M+H + ]=443 Calculated for C 25 H 34 N 2 O 3 S=442
Example 283
1-(3-Chloro-benzyl)-7-[1-(propane-1-sulfonyl)-azetidin-3-yl]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
283.1 3-[8-(3-Chloro-benzyl)-7-ethoxycarbonylamino-5,6,7,8-tetrahydro-naphthalen-2-yl]azetidine-1-carboxylic acid tert-butyl ester









A suspension of zinc powder (152 mg, 2.3 mmol) in 1 ml of DMA in a dry flask was heated under N 2 to 65-70° C. A mixture of TMS-CI (28 mg, 0.26 mmol) and 1,2-dibromoethane (49 mg, 0.26 mmol) was added dropwise, stirred for 30 min, followed by slow (15 min) addition of 3-iodo-azetidine-1-carboxylic acid tert-butyl ester (510 mg, 1.8 mmol) in 1 ml DMA. The reaction was cooled slowly (3 h) to room temperature, added to a mixture of 8-(3,4-chlorobenzyl)-7-[(ethoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (633 mg, 1.3 mmol, prepared in analogy to example 29), CuI (74 mg, 0.39 mmol) and PdCl 2 (dppf) (63 mg, 0.08 mmol) in 4 ml DMA preheated to 70° C. and stirred for 7 h at 70° C. Water and MTB (1:1 20 ml) were added and the resulting mixture filtered. The organic layer was separated, dried (Na 2 SO 4 ) and the solvent evaporated. Purification by chromatography afforded 560 mg of product (white foam).
283.2 1-(3-Chloro-benzyl)-7-[1-(propane-1-sulfonyl)-azetidin-3-yl]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared in three steps from 3-[8-(3-chloro-benzyl)-7-ethoxycarbonylamino-5,6,7,8-tetrahydro-naphthalen-2-yl]azetidine-1-carboxylic acid tert-butyl ester in analogy to example 46/47.
Cleavage of Boc-group was done in formic acid.
ESI-MS [M+H + ]=433 Calculated for C 23 H 29 ClN 2 O 2 S=432
Example 284
1-Benzyl-7-[1-(propane-1-sulfonyl)-azetidin-3-yl]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared in analogy to example 283.
ESI-MS [M+H + ]=399 Calculated for C 23 H 30 N 2 O 2 S=398
Example 285
{1-(3-Chloro-benzyl)-7-[1-(propane-1-sulfonyl)-azetidin-3-ylmethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-carbamic acid ethyl ester
285.1 1-(Propane-1-sulfonyl)-azetidine-3-carboxylic acid methyl ester









Prepared by standard procedure from azetidine-3-carboxylic acid methyl ester and propane-1-sulfonyl chloride (e.g. example 279).
285.2 [1-(Propane-1-sulfonyl)-azetidin-3-yl]methanol









Prepared by reduction of 1-(propane-1-sulfonyl)-azetidine-3-carboxylic acid methyl with LiAlH 4 in THF at room temperature to 50° C. (e.g. example 300).
285.3 Methanesulfonic acid 1-(propane-1-sulfonyl)-azetidin-3-ylmethyl ester









Prepared by standard procedure from [1-(propane-1-sulfonyl)-azetidin-3-yl]methanol and methan-1-sulfonyl chloride (e.g. example 40)
285.4 {1-(3-Chloro-benzyl)-7-[1-(propane-1-sulfonyl)-azetidin-3-ylmethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-carbamic acid ethyl ester









Prepared from 1-(3-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate and methanesulfonic acid 1-(propane-1-sulfonyl)-azetidin-3-ylmethyl ester in analogy to example 315.
ESI-MS [M+H + ]=536 Calculated for C 27 H 35 ClN 2 O 5 S=535
Example 286
1-(3-Chloro-benzyl)-7-[1-(propane-1-sulfonyl)-azetidin-3-ylmethoxy]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared from {1-(3-chloro-benzyl)-7-[1-(propane-1-sulfonyl)-azetidin-3-ylmethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-carbamic acid ethyl ester in analogy to example 3. ESI-MS [M+H + ]=463 Calculated for C 24 H 31 ClN 2 O 3 S=462
Example 287
[1-(3-Chloro-benzyl)-7-(2-cyclopropylmethanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









Prepared in analogy to example 3.
ESI-MS [M+H + ]=521 Calculated for C 26 H 33 ClN 2 O 5 S=520
Example 288
N-{2-[7-Amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide hydrochloride









Prepared from [1-(3-chloro-benzyl)-7-(2-cyclopropylmethanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 3. ESI-MS [M+H + ]=449 Calculated for C 23 H 29 ClN 2 O 3 S=448
Example 289
[1-(3-Chloro-benzyl)-7-(1-cyclopropylmethanesulfonyl-azetidin-3-ylmethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









Prepared from 1-(3-chlorobenzyl)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate and methanesulfonic acid Methanesulfonic acid 1-cyclopropylmethanesulfonyl-azetidin-3-yl methylester (prepared in analogy to example 285) in analogy to example 315. ESI-MS [M+H + ]=547 Calculated for C 28 H 35 ClN 2 O 5 S=546
Example 290
{1-(3-Chloro-benzyl)-7-[2-(cyclopropylmethanesulfonyl-methyl-amino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared from [1-(3-chloro-benzyl)-7-(2-cyclopropylmethanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 45. ESI-MS [M+H + ]=535 Calculated for C 27 H 35 ClN 2 O 5 S=534
Example 291
N-{2-[7-Amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-N-methyl-methanesulfonamide









{1-(3-Chloro-benzyl)-7-[2-(cyclopropylmethanesulfonyl-methyl-amino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester in analogy to example 3. ESI-MS [M+H + ]=463 Calculated for C 24 H 31 ClN 2 O 3 S=462
Example 292
1-Benzyl-7-[1-(propane-1-sulfonyl)-azetidin-3-ylmethoxy]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared in analogy to example 46.
ESI-MS [M+H + ]=429 Calculated for C 24 H 31 ClN 2 O 3 S=428
Example 293
Propane-1-sulfonic acid {2-[7-amino-8-(2-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to example 3.
ESI-MS [M+H + ]=437 Calculated for C 22 H 29 ClN 2 O 3 S=436
Example 294
Cyclopropanesulfonic acid {2-[7-amino-8-(2-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in analogy to example 3.
ESI-MS [M+H + ]=435 Calculated for C 22 H 27 ClN 2 O 3 S=434
Example 295
N-{2-[7-Amino-8-(2-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide hydrochloride









Prepared in analogy to example 3.
ESI-MS [M+H + ]=449 Calculated for C 23 H 29 ClN 2 O 3 S=448
Example 296
N-{3-[7-Amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]propyl}-C-cyclopropyl-methanesulfonamide hydrochloride
296.1 [7-(3-tert-Butoxycarbonylamino-propyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









A solution of tert-butyl allylcarbamate (297 mg, 1.9 mmol) in dry THF under nitrogen was added dropwise at 0° C. to 9-BBN dissolved in THF (0.5 M, 2.3 ml, 1.2 mmol) and stirred for 4 h. This mixture was subsequently treated with 8-(3,4-chlorobenzyl)-7-[(ethoxycarbonyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (250 mg, 0.5 mmol), palladium(11)acetate (11.5 mg, 0.05 mmol), triphenylphosphine (27 mg, 0.1 mmol) and cesium carbonate (333 mg, 1 mmol) after which the mixture was heated to reflux for 2 h.
The solvent was evaporated the residue dissolved in ethylacetate, extracted with water, dried (Na 2 SO 4 ). Evaporation of solvent gave 0.51 g of a brown oil which was treated with diisopropyl ether to afford 91 mg of a brownish powder.
296.2 N-{3-[7-Amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]propyl}-C-cyclopropyl-methanesulfonamide hydrochloride









Prepared from [7-(3-tert-butoxycarbonylamino-propyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester in analogy to example 3. ESI-MS [M+H + ]=447 Calculated for C 24 H 31 ClN 2 O 2 S=446
Example 297
Propane-1-sulfonic acid {3-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-propyl}-amide hydrochloride









Prepared in analogy to example 296.
ESI-MS [M+H + ]=435 Calculated for C 23 H 31 ClN 2 O 2 S=434
Example 298
{1-(2-Chloro-benzyl)-7-[2-(1-methyl-1H-imidazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in analogy to example 3.
ESI-MS [M+H + ]=547 Calculated for C 26 H 31 ClN 4 O 5 S=546
Example 299
{1-(2-Chloro-benzyl)-7-[2-(1-methyl-1H-pyrazole-4-sulfonylamino)-ethoxy]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









Prepared in analogy to example 3.
ESI-MS [M+H + ]=547 Calculated for C 26 H 31 ClN 4 O 5 S=546
Example 300
N-{2-[8-(3-Chloro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide hydrochloride









A solution of LiAlH 4 in THF (1 M, 1.5 ml, 1.5 mmol) was added dropwise to [1-(3-chloro-benzyl)-7-(2-cyclopropylmethanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester (523 mg, 1 mmol, example 287) dissolved in 100 ml of dry THF. The mixture was heated to reflux for 1 h, treated with 2N NaOH, and extracted with CH 2 Cl 2 . The organic layer was extracted with sat. NaHCO 3 and brine, dried (Na 2 SO 4 ) filtered and the solvent evaporated. Purification by chromatography afforded 324 mg of product as colorless oil which was transformed to the hydrochloride in a mixture of HCl in isopropanol. (325 mg, white powder)
ESI-MS [M+H + ]=463 Calculated for C 24 H 31 ClN 2 O 3 S=462
Example 301
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-amino-8-(2-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to example 3.
ESI-MS [M+H + ]=475 Calculated for C 23 H 27 ClN 4 O 3 8=474
Example 302
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[8-(2-chloro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to example 3/300.
ESI-MS [M+H + ]=489 Calculated for C 24 H 29 ClN 4 O 3 8=488
Example 303
1-Methyl-1H-imidazole-4-sulfonic acid {2-[8-(2-chloro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in analogy to example 3/300.
ESI-MS [M+H + ]=489 Calculated for C 24 H 29 ClN 4 O 3 S=488
Example 304
Propane-1-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-ethyl}-amide hydrochloride
304.1 [7-(2-Benzyloxycarbonylamino-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









A mixture of potassium (2-(benzyloxycarbonylamino)ethyl)trifluoroborate (1,130 g, 3.96 mmol), cesium carbonate (2.58 g, 7.93 mmol), 8-(3-chlorobenzyl)-7-(ethoxycarbonylamino)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (1.3 g, 2.64 mmol), Pd(OAc) 2 (0.030 g, 0.132 mmol) and 2-dicyclohexyphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl (0.130 g, 0.264 mmol) under N 2 in toluene/water 3:1 (15 ml) was heated to refluxed for 13 h. The reaction was filtered, the solvent evaporated and the residue purified by chromatography to afford 1.04 g of product as colorless oil.
304.2 [7-(2-Amino-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester









To [7-(2-benzyloxycarbonylamino-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester (500 mg, 0.960 mmol) was added at room temperature 8 ml of 33% HBr in acetic acid. After 2 h the mixture was diluted with CH 2 Cl 2 , washed twice with NaHCO 3 , dried and filtered. The solvent was evaporated to obtain the product as a yellow oil (392 mg), which was used without further purification.
304.3 Propane-1-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]ethyl}-amide hydrochloride









Prepared from [7-(2-amino-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester in analogy to example 3.
ESI-MS [M+H + ]=421 Calculated for C 22 H 29 ClN 2 O 2 S=420
Example 305
1-Methyl-1H-imidazole-4-sulfonic acid {2-[7-amino-8-(2-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in analogy to example 3.
ESI-MS [M+H + ]=475 Calculated for C 23 H 27 ClN 4 O 3 S=474
Example 306
N-[1-(3-Chloro-benzyl)-7-(2-cyclopropylmethanesulfonylamino-ethoxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetamide









Prepared in analogy to example 214.
ESI-MS [M+H + ]=491 Calculated for C 25 H 31 ClN 2 O 4 S=490
Example 307
N-{2-[8-(3-Chloro-benzyl)-7-ethylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide hydrochloride









Prepared in analogy to example 300.
ESI-MS [M+H + ]=477 Calculated for C 25 H 33 ClN 2 O 3 S=476
Example 308
Propane-1-sulfonic acid {3-[8-(3-chloro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yl]-propyl}-amide hydrochloride









Prepared in analogy to examples 297/300.
ESI-MS [M+H + ]=449 Calculated for C 24 H 33 ClN 2 O 2 S=448
Example 309
Propane-1-sulfonic acid {2-[8-(3-chloro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yl]-ethyl}-amide









Prepared in analogy to examples 304/300.
ESI-MS [M+H + ]=435 Calculated for C 23 H 31 ClN 2 O 2 S=434
Example 310
N-{2-[7-Amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]ethyl}-C-cyclopropyl-methanesulfonamide hydrochloride









Prepared in analogy to example 304.
ESI-MS [M+H + ]=433 Calculated for C 23 H 29 ClN 2 O 2 S=432
Example 311
Propane-1-sulfonic acid {2-[8-(2-fluoro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to examples 3/300.
ESI-MS [M+H + ]=435 Calculated for C 23 H 31 FN 2 O 3 =434
Example 312
C-Cyclopropyl-N-{2-[8-(2-fluoro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-methanesulfonamide hydrochloride









Prepared in analogy to examples 3/300.
ESI-MS [M+H + ]=447 Calculated for C 24 H 31 FN 2 O 3 S=446
Example 313
1-Methyl-1H-imidazole-4-sulfonic acid {2-[8-(3-chloro-benzyl)-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yl]ethyl}-amide









Prepared in analogy to examples 304/300.
ESI-MS [M+H + ]=473 Calculated for C 24 H 29 ClN 4 O 2 S=472
Example 314
Propane-1-sulfonic acid [2-(8-cyclohexylmethyl-7-methylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-amide trifluoroacetate









Prepared in analogy to examples 3/300.
ESI-MS [M+H + ]=423 Calculated for C 23 H 38 N 2 O 3 S=422
Example 315
1-Methyl-1H-imidazole-4-sulfonic acid {2-[8-(2-chloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride
315.1 1-Methyl-1H-imidazole-4-sulfonic acid {2-[8-(2-chloro-benzyl)-7-(2-oxo-pyrrolidin-1-yl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide









Prepared in analogy to example 263.
315.2 1-Methyl-1H-imidazole-4-sulfonic acid {2-[8-(2-chloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared from compound of previous step by reduction with LiAlH 4 in analogy to 300. ESI-MS [M+H + ]=529 Calculated for C 27 H 33 ClN 4 O 3 S=528
Example 316
1,2-Dimethyl-1H-imidazole-4-sulfonic acid {2-[7-amino-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to example 3.
ESI-MS [M+H + ]=489 Calculated for C 24 H 29 ClN 4 O 3 S=488
Example 317
N-{2-[8-(3-Chloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide hydrochloride









Prepared in analogy to examples 264/88.
ESI-MS [M+H + ]=503 Calculated for C 27 H 35 ClN 2 O 3 S=502
Example 318
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[8-(3-chloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to examples 264/88.
ESI-MS [M+H + ]=529 Calculated for C 27 H 33 ClN 4 O 3 S=528
Example 319
1-Methyl-1H-imidazole-4-sulfonic acid {2-[8-(3-chloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-amide hydrochloride









Prepared in analogy to examples 264/88.
ESI-MS [M+H + ]=529 Calculated for C 27 H 33 ClN 4 O 3 S=528
Example 320
N-{2-[7-Azetidin-1-yl-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide
320.1 1-[1-(3-Chloro-benzyl)-7-methoxy-1,2,3,4-tetrahydro-naphthalen-211]-azetidine









Prepared in analogy to example 264 using 1,3-dibromopropane instead of 1,4-dibromobutane.
320.2 N-{2-[7-Azetidin-1-yl-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]ethyl}-C-cyclopropyl-methanesulfonamide









Prepared from compound of previous step in analogy to example 88.
ESI-MS [M+H + ]=489 Calculated for C 26 H 33 ClN 2 O 3 S=488
Example 321
1-Methyl-1H-imidazole-4-sulfonic acid {2-[7-azetidin-1-yl-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to example 320.
ESI-MS [M+H + ]=515 Calculated for C 26 H 31 ClN 4 O 3 S=514
Example 322
1-Methyl-1H-pyrazole-4-sulfonic acid {2-[7-azetidin-1-yl-8-(3-chloro-benzyl)-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to example 320.
ESI-MS [M+H + ]=515 Calculated for C 26 H 31 ClN 4 O 3 S=514
Example 323
Propane-1-sulfonic acid {2-[8-(3-chloro-benzyl)-7-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yloxy]-ethyl}-amide hydrochloride









Prepared in analogy to examples 264/88.
ESI-MS [M+H + ]=491 Calculated for C 26 H 35 ClN 2 O 3 S=490
Example 324
1-Methyl-1H-pyrazole-4-sulfonic acid [2-(7-azetidin-1-yl-8-benzyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]amide hydrochloride









Prepared in analogy to example 320.
ESI-MS [M+H + ]=481 Calculated for C 26 H 32 N 4 O 3 S=480
Example 325
1-Benzyl-7-[2-(propane-1-sulfonyl)-ethyl]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
325.1 [1-(3-Chloro-benzyl)-7-vinyl-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester









Synthesis performed in analogy to: Organic Letters; 2002, Vol 4; p. 107-109.
A solution of potassium trifluoro(vinyl)borate (1,000 g, 7.46 mmol), PdCl 2 (dppf)-CH 2 Cl 2 adduct (0.102 g, 0.124 mmol), 8-(3-chlorobenzyl)-7-(ethoxycarbonylamino)-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (3.06 g, 6.22 mmol) and triethylamine (0.867 ml, 6.22 mmol) in 100 ml n-BuOH was stirred under N 2 at 85-90° C. for 4 h and then cooled to room temperature.
Water was added, followed by extraction with ether. The ethereal solution was washed with brine, dried, filtered and evaporated to obtain a brown oil. Chromatography afforded 1.55 g of product as a pale yellow solid.
325.2 [1-(3-Chloro-benzyl)-7-(2-hydroxy-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester









BH 3 .DMS (1 M in THF, 0.838 ml, 0.838 mmol) was added a solution of ethyl 1-(3-chlorobenzyl)-7-vinyl-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1.55 g, 4.19 mmol) in 20 ml dry THF. The reaction was stirred at 60° C. for 1 h and cooled to room temperature.
Some water was added to destroy the excess of borane complex and the resulting mixture refluxed for 1 h with 30% H 2 O 2 (8.56 ml, 84 mmol) and 2N NaOH (9.74 ml, 19.49 mmol). The reaction mixture was extracted with CH 2 Cl 2 , washed with water and brine, dried, filtered and the solvent evaporated to obtain a pale brown solid (1.7 g), which was purified by chromatography to afford 854 mg of product as a white solid.
325.3 [7-(2-Bromo-ethyl)-1-(3-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester









To a solution of [1-(3-chloro-benzyl)-7-(2-hydroxy-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester (554 mg, 1.428 mmol) in 15 ml dry CH 2 Cl 2 cooled to 0° C. was added triphenylphosphine (562 mg, 2.142 mmol) and carbon tetrabromide (0.208 ml, 2.142 mmol). The mixture was stirred for 1 h, after which solvents were evaporated. The residue was purified by chromatography to obtain 277 mg of product as a white solid.
325.4 [1-(3-Chloro-benzyl)-7-(2-propylsulfanyl-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]carbamic acid ethyl ester









To a suspension of NaH (4.73 mg, 0.177 mmol) in 3 ml dry DMF under N 2 was added 1-propanthiol (0.012 ml, 0.133 mmol, dissolved in 1 ml dry DMF). The reaction was stirred at room temperature for 2 h, followed by addition of triethylamine (0.019 ml, 0.133 mmol) and ethyl 7-(2-bromoethyl)-1-(3-chlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (40 mg, 0.089 mmol, dissolved in 2 ml dry DMF). The mixture was stirred at room temperature over night, the solvent evaporated, the residue re-dissolved in ethyl acetate, washed with water, citric acid, NaHCO 3 and brine and filtered. The solvent was evaporated to obtain 31 mg of an off white solid which was used without further purification.
325.5 {1-(3-Chloro-benzyl)-7-[2-(propane-1-sulfonyl)-ethyl]-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid ethyl ester









To a cooled mixture (0° C.) of ethyl 1-(3-chlorobenzyl)-7-(2-(propylthio)ethyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (31.4 mg, 0.070 mmol) in 2 ml ethyl acetate was added m-CPBA (33.4 mg, 0.155 mmol). The reaction was stirred for 2 h allowing warming up to room temperature. The mixture was diluted with ethyl acetate, washed with Na—HCO 3 , water and brine, dried, filtered and the solvent evaporated to obtain a white solid, which was purified by chromatography (27 mg).
325.6 [1-Benzyl-7-(2-propylsulfanyl-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester









Ethyl 1-(3-chlorobenzyl)-7-(2-(propylsulfonyl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (27.1 mg, 0.057 mmol) and ammonium formate (71.5 mg, 1.134 mmol) were dissolved in 5 ml MeOH. Pd/C (0.845 mg, 7.94 μmol) was added and stirred at 80° C. for 4 h. The mixture was filtered, the solvent evaporated, the residue re-dissolved in ethyl acetate, which was subsequently washed with water, NaHCO 3 and brine, dried, filtered. Solvent was evaporated to obtain white solid which was purified by chromatography affording 12.7 mg of product as a white solid.
325.7 1-Benzyl-7-[2-(propane-1-sulfonyl)-ethyl]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared in analogy to example 3 [1-Benzyl-7-(2-propylsulfanyl-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-carbamic acid ethyl ester.
ESI-MS [M+H + ]=372 Calculated for C 22 H 29 NO 2 S=371
Example 326
1-(3-Chloro-benzyl)-7-[2-(propane-1-sulfonyl)-ethyl]-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride









Prepared in analogy to example 325 leaving out the de-chlorination step.
ESI-MS [M+H + ]=406 Calculated for C 22 H 29 ClNO 2 S=405
Biological Testing
1. [ 3 H]-Glycine uptake into recombinant CHO cells expressing human GlyT1: Human GlyT1c expressing recombinant hGlyT1c — 5_CHO cells were plated at 20,000 cells per well in 96 well Cytostar-T scintillation microplates (Amersham Biosciences) and cultured to sub-confluency for 24 h. For glycine uptake assays the culture medium was aspirated and the cells were washed once with 100 μl HBSS (Gibco BRL, #14025-050) with 5 mM L-Alanine (Merck #1007). 80 μl HBSS buffer were added, followed by 10 μl inhibitor or vehicle (10% DMSO) and 10 μl [ 3 H]-glycine (TRK71, Amersham Biosciences) to a final concentration of 200 nM for initiation of glycine uptake. The plates were placed in a Wallac Microbeta (PerkinElmer) and continuously counted by solid phase scintillation spectrometry during up to 3 hours. Nonspecific uptake was determined in the presence of 10 μM Org24598. IC 50 calculations were made by four-parametric logistic nonlinear regression analysis (GraphPad Prism) using determinations within the range of linear increase of [ 3 H]-glycine incorporation between 60 and 120 min.
2. Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1:
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-1715, 2008.
The following results were obtained with the compounds disclosed in the examples:







TABLE 1




Glycine uptake
radioligand binding

Example
IC 50 [μmol]
K iapp [μmol]









1
≦1000
≦10

2
≦1
≦0.1

3
≦0.01
≦0.01

4
≦0.01
≦0.01

5
≦1
≦1

6
≦1
≦0.1

7
≦10
≦10

8
≦0.1
≦0.1

9
≦1
≦1

10
≦100
≦10

11
≦1
≦0.1

12
≦100
≧10

13
≦1000
≦100

14
≦1000
≦100

15
≦1
≦1

16
≦10
≦10

17
≦10
≦1

18
≦0.1
≦0.01

19
≦100
≦10

20
≦0.1
≦0.01

21
≦1000
≦100

22
≦1000
≦10

23
≦100
≦10

24
≦10
≦0.1

25
≦1
≦0.1

26
≦1000
≦10

27
≦0.01
≦0.01

28
≦0.01
≦0.01

29
≦100
≦10

30
≦100
≦100

31
≦1
≦0.1

32
≦100
≦10

33
≦1
≦1

34
≦1000
≦10

35
≦100
≧100

36
≦10
≦100

37
≦100
≦10

38
≦100
≦100

39
≦1000
≦10

40
≦100
≦10

41
≦100
≦10

42
≦0.1
≦0.1

43
≦1
≦0.1

44
≦0.1
≦0.1

45
≦0.1
≦0.1

46
≦1
≦1

47
≦0.01
≦0.01

48
≦0.01
≦0.01

49
≦100
≦100

50
≦10
≦1

51
≦1000
≦100

52
≦10
≦10

53
≦1000
≦10

54
≧100
≦10

55
≦0.1
≦0.01

56
≦1
≦0.1

57
≦10
≦1

58
≦10
≦1

59
≦10
≦1

60
≧100
≦10

61
≦1000
≦10

62
≦1000
≦10

63
≧100
≦10

64
≦1000
≦10

65
≦100
≧10

66
≦1
≦0.1

67
≦1
≦0.1

68
≦10
≦1

69
≦10
≦1

70
≦1
≦0.1

71
≦0.1
≦0.01

72
≦10
≦10

73
≦10
≦1

74
≦100
≧10

75
≦10
≦1

76
≦1000
≦100

77
≦1
≦0.1

78
≦10
≦10

79
≦1
≦0.1

80
≦1
≦1

81
≧1000
≦10

82
≦1
≦0.1

83
≦10
≦1

84
≦10
≦10

85
—
≦1

86
—
≦10

87
—
≦10

88
—
≦0.1

89
—
≦0.1

90
—
≦1

91
—
≦0.1

92
—
—

93
—
≦1

94
—
≦0.1

95
—
≦0.01

967
—
≦1

98
—
≦1

99
—
≦0.1

100
—
≦1

100
—
≦10

101
—
≦0.1

102
—
≦1

103
—
≦10

104
—
≦1

105
—
≦0.1

106
—
≦1

107
—
≦0.1

108
—
≦0.01

109
—
≦0.1

110
—
≦1

111
—
≦0.1

112
—
≦0.1

113
—
≦0.1

114
—
≦1

115
—
—

116
—
≦0.01

117
—
≦0.01

118
—
≦0.1

119
—
≦0.01

120
—
≦0.1

121
—
≦0.01

122
—
≦10

123
—
≦10

124
—
≦1

125
—
≦1

126
—
≦0.01

127
—
≦0.1

128
—
≦0.1

129
—
≦0.01

130
—
≦0.01

131
—
≦0.1

132
—
≦0.1

133
—
≦0.1

134
—
≦1

135
—
≦0.1

136
—
≦0.1

137
—
≦0.01

138
—
≦0.01

139
—
≦0.01

140
—
≦0.01

141
—
≦0.01

142
—
≦0.1

143
—
≦0.01

144
—
≦1

145
—
≦0.01

146
—
≦0.01

147
—
≦0.1

148
—
≦0.1

149
—
≦0.1

150
—
≦0.01

151
—
≦0.01

152
—
≦0.01

153
—
≦0.1

154
—
≦0.1

155
—
≦1

156
—
≦1

157
—
≦0.1

158
—
≦0.01

159
—
≦0.1

160
—
≦0.01

161
—
≦0.01

162
—
≦0.01

163
—
≦0.01

164
—
≦0.01

165
—
≦0.01

166
—
≦0.1

167
—
≦10

168
—
≦10

169
—
≦0.01

170
—
>10

171
—
≦0.1

172
—
≦0.01

173
—
≦0.01

174
—
≦1

175
—
≦1

176
—
≦0.1

177
—
≦0.01

178
—
≦0.01

179
—
≦1

180
—
≦0.01

181
—
≦0.1

182
—
≦0.1

183
—
≦1

184
—
≦0.1

185
—
≦1

186
—
≦1

187
—
≦0.01

188
—
≦0.1

189
—
≦10

190
—
≦0.01

191
—
≦1

192
—
—

193
—
≦0.01

194
—
—

195
—
—

196
—
≦10

197
—
≦10

198
—
≦0.1

199
—
≦0.1

200
—
≦0.1

201
—
≦0.1

202
—
≦0.1

203
—
≦0.01

204
—
≦0.1

205
—
≦0.1

206
—
≦0.1

207
—
≦0.1

208
—
≦0.1

209
—
≦0.1

210
—
≦0.1

211
—
≦1

212
—
≦1

213
—
≦0.1

214
—
≦10

215
—
≦10

216
—
≦10

217
—
≦10

218
—
≦10

219
—
≦0.1

220
—
≦1

221
—
≦0.1

222
—
≦1

223
—
≦0.1

224
—
≦0.1

225
—
≦0.1

226
—
≦0.1

227
—
≦0.1

228
—
≦0.1

229
—
≦1

230
—
≦0.01

231
—
≦0.01

232
—
≦0.1

233
—
≦0.1

234
—
≦0.1

235
—
≦0.01

236
—
≦1

237
—
≦10

238
—
≦0.01

239
—
≦1

240
—
≦0.01

241
—
≦0.1

242
—
≦0.01

243
—
≦0.01

244
—
≦0.01

245
—
≦1

246
—
≦0.01

247
—
≦0.01

248
—
≦0.01

249
—
≦0.1

250
—
≦0.01

251
—
≦0.1

252
—
≦0.01

253
—
≦1

254
—
≦0.01

255
—
≦1

256
—
≦0.1

257
—
≦0.1

258
—
≦0.1

259
—
≦1

260
—
≦1

261
—
≦1

262
—
≦0.1

263
—
≦1

264
—
≦1

265
—
≦1

266
—
≦1

267
—
≦0.1

268
—
≦0.01

269
—
≦0.01

270
—
≦0.1

271
—
≦0.1

272
—
≦0.1

273
—
≦1

274
—
≦0.1

275
—
≦0.1

276
—
≦10

277
—

278
—

279
—
≦10

280
—
≦10

281
—
≦0.1

282
—
≦0.1

283
—
≦1

284
—
≦1

285
—
≦10

286
—
≦10

287
—
≦10

288
—
≦0.01

289
—
>10

290
—
≦10

291
—
≦0.01

292
—
≦1

293
—
≦1

294
—
≦10

295
—
≦1

296
—
≦0.1

297
—
≦0.1

298
—
≦10

299
—
>10

300
—
≦0.01

301
—
≦0.01

302
—
≦0.1

303
—
≦0.1

304
—
≦1

305
—
≦0.1

306
—
≦0.1

307
—
≦0.01

308
—
≦0.01

309
—
≦0.1

310
—
≦1

311
—
≦0.1

312
—
≦0.1

313
—
≦0.1

314
—
≦1

315
—
≦1

316
—
≦1

317
—
≦0.1

318
—
≦0.01

319
—
≦0.1

320
—
≦0.1

321
—
≦0.01

322
—
≦0.01

323
—
≦1

324
—
≦0.01

325
—
≦1

326
—
≦1