(en)Compositions and methods are provided for determining in a subject a risk for having, or presence of, altered bone mineral density such as osteoporosis or osteopenia or other conditions characterized by decreased or increased bone density. Specifically, the invention relates to determination of a sclerostin gene region nucleotide polymorphism (SRP) in DNA of the sclerostin gene region of human chromosome 17. In certain embodiments, SRPs that indicate an increased risk for altered bone mineral density occur as gender-associated polymorphisms. Isolated polynucleotides comprising representative SRPs are also provided.

1.ApplicationNumber: US-40816803-A
1.PublishNumber: US-2003235847-A1
2.Date Publish: 20031225
3.Inventor: PAEPER BRYAN W.
PROLL SEAN
CHARMLEY PATRICK R.
BRUNKOW MARY E.
UITTERLINDEN ANDREAS GERARDUS

4.Inventor Harmonized: PAEPER BRYAN W(US)
PROLL SEAN(US)
CHARMLEY PATRICK R(US)
BRUNKOW MARY E(US)
UITTERLINDEN ANDREAS GERARDUS(NL)

5.Country: US
6.Claims:
(en)Compositions and methods are provided for determining in a subject a risk for having, or presence of, altered bone mineral density such as osteoporosis or osteopenia or other conditions characterized by decreased or increased bone density. Specifically, the invention relates to determination of a sclerostin gene region nucleotide polymorphism (SRP) in DNA of the sclerostin gene region of human chromosome 17. In certain embodiments, SRPs that indicate an increased risk for altered bone mineral density occur as gender-associated polymorphisms. Isolated polynucleotides comprising representative SRPs are also provided.

7.Description:
(en)CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of U.S. Provisional Patent Application No. 60/370,088, filed Apr. 3, 2002, which is incorporated herein by reference in its entirety.



BACKGROUND OF THE INVENTION
[0002] 1. Field of the Invention
[0003] The present invention relates to the field of molecular biology, and more particularly, the detection of nucleotide polymorphisms including single nucleotide polymorphisms, and still more particularly nucleotide polymorphisms associated with osteoporosis.
[0004] 2. Description of the Related Art
[0005] Two or three distinct phases of changes to bone mass occur over the life of an individual (see Riggs, West J. Med. 154:63-77, 1991). The first phase occurs in both men and women, and proceeds to attainment of a peak bone mass. This first phase is achieved through linear growth of the endochondral growth plates, and radial growth due to a rate of periosteal apposition. The second phase begins around age 30 for trabecular bone (flat bones such as the vertebrae and pelvis) and about age 40 for cortical bone (e.g., long bones found in the limbs) and continues to old age. This phase is characterized by slow bone loss, and occurs in both men and women. In women, a third phase of bone loss also occurs, most likely due to postmenopausal estrogen deficiencies. During this phase alone, women may lose an additional 10% of bone mass from the cortical bone and 25% from the trabecular compartment (see Riggs, supra).
[0006] Loss of bone mineral content can be caused by a wide variety of conditions including, for instance, osteoporosis, osteopenia, bone dysplasia and bone fracture, and may result in significant medical problems. For example, osteoporosis is a debilitating disease in humans characterized by marked decreases in skeletal bone mass and mineral density, structural deterioration of bone including degradation of bone microarchitecture and corresponding increases in bone fragility and susceptibility to fracture in afflicted individuals. Osteoporosis in humans is preceded by clinical osteopenia (bone mineral density that is greater than one standard deviation but less than 2.5 standard deviations below the mean value for young adult bone), a condition found in approximately 25 million people in the United States. Another 7-8 million patients in the United States have been diagnosed with clinical osteoporosis (defined as bone mineral content greater than 2.5 standard deviations below that of mature young adult bone). Osteoporosis is one of the most expensive diseases for the health care system, costing tens of billions of dollars annually in the United States. In addition to health care-related costs, long-term residential care and lost working days add to the financial and social costs of this disease. Worldwide approximately 75 million people are at risk for osteoporosis. See, e.g., Eisman, 1999 Endocrine Rev. 20:788; Giguere et al., 2000 Clin. Genet. 57:161; Zmuda et al., 1999 Genetic Epidemiol. 16:356; Uitterlinden, 1999 European Calcified Tissue Society [online] www.ectsoc.org/reviews/005_uitt.htm.
[0007] The frequency of osteoporosis in the human population increases with age, and among Caucasians is predominant in women (who comprise 80% of the osteoporosis patient pool in the United States). The increased fragility and susceptibility to fracture of skeletal bone in the aged is aggravated by the greater risk of accidental falls in this population. More than 1.5 million osteoporosis-related bone fractures are reported in the United States each year. Fractured hips, wrists, and vertebrae are among the most common injuries associated with osteoporosis. Hip fractures in particular are extremely uncomfortable and expensive for the patient, and for women correlate with high rates of mortality and morbidity.
[0008] Although osteoporosis has been defined as an increase in the risk of fracture due to decreased bone mass, none of the presently available treatments for skeletal disorders can substantially increase the bone density of adults. There is a strong perception among all physicians that drugs are needed which could increase bone density in adults, particularly in the bones of the wrist, spinal column and hip that are at risk in osteopenia and osteoporosis.
[0009] Current strategies for the prevention of osteoporosis may offer some benefit to individuals but cannot ensure resolution of the disease. These strategies include moderating physical activity (particularly in weight-bearing activities) with the onset of advanced age, including adequate calcium in the diet, and avoiding consumption of products containing alcohol or tobacco. For patients presenting with clinical osteopenia or osteoporosis, all current therapeutic drugs and strategies are directed to reducing further loss of bone mass by inhibiting the process of bone absorption, a natural component of the bone remodeling process that occurs constitutively.
[0010] For example, estrogen is now being prescribed to retard bone loss. There is, however, some controversy over whether there is any long term benefit to patients and whether there is any effect at all on patients over 75 years old. Moreover, use of estrogen is believed to increase the risk of breast and endometrial cancer.
[0011] High doses of dietary calcium, with or without vitamin D has also been suggested for postmenopausal women. However, high doses of calcium can often have unpleasant gastrointestinal side effects, and serum and urinary calcium levels must be continuously monitored (see Khosla and Rigss, Mayo Clin. Proc. 70:978-982, 1995).
[0012] Other therapeutics which have been suggested include calcitonin, bisphosphonates, anabolic steroids and sodium fluoride. Such therapeutics however, have undesirable side effects (e.g., calcitonin and steroids may cause nausea and provoke an immune reaction, bisphosphonates and sodium fluoride may inhibit repair of fractures, even though bone density increases modestly) that may prevent their usage (see Khosla and Rigss, supra).
[0013] No currently practiced therapeutic strategy involves a drug that stimulates or enhances the growth of new bone mass. Further the present invention provides methods for determining whether someone is susceptible to osteoporosis. Further, the present invention provides other, related advantages.
[0014] Summary of the Invention It is an aspect of the present invention to provide a method for determining a risk for or presence of altered bone mineral density in a subject, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism in a biological sample from a subject, the sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1, wherein the presence of at least one sclerostin gene region nucleotide polymorphism at a position that corresponds to a non-coding region of SEQ ID NO:1 indicates an increased risk of altered bone mineral density. In one embodiment the invention provides a method for determining a risk for or presence of altered bone mineral density in a subject, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism in a biological sample from a subject, said sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1; and determining gender of the subject, wherein the presence of at least one gender-associated sclerostin gene region nucleotide polymorphism indicates an increased risk of altered bone mineral density. In another embodiment the invention provides a method for determining a risk for or presence of altered bone mineral density in a subject, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism in a biological sample from a subject, said sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1, wherein the presence of at least one sclerostin gene region nucleotide polymorphism in the sample indicates an increased risk of altered bone mineral density, and wherein the polymorphism is located at a nucleotide that corresponds to a nucleotide position of SEQ ID NO:1 that is selected from position 4103, 17966, 18293, 58083, 74235 and 91068.
[0015] In another embodiment there is provided a method for determining a risk for or presence of altered bone mineral density in a subject, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism in a biological sample from a female subject, said sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1, wherein the presence of at least one sclerostin gene region nucleotide polymorphism in the sample indicates an increased risk of decreased bone mineral density, and wherein the polymorphism is located at a nucleotide that corresponds to a GGA trinucleotide insertion between positions 10565 and 10566 in SEQ ID NO:1. In another embodiment the invention provides a method for determining a risk for or presence of altered bone mineral density in a subject, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism in a biological sample from a male subject, said sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1, wherein the presence of at least one sclerostin gene region nucleotide polymorphism in the sample indicates an increased risk of increased bone mineral density, and wherein the polymorphism is located at a nucleotide that corresponds to position 91068 in SEQ ID NO:1. In a further embodiment the polymorphism at position 91068 comprises an A91068G substitution.
[0016] Turning to another embodiment of the present invention, there is provided a method for determining a risk for or presence of altered bone mineral density in a subject, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism in a biological sample from a subject, said sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1, wherein the presence of at least one sclerostin gene region nucleotide polymorphism in the sample indicates an increased risk of altered bone mineral density, and wherein the polymorphism is located at a nucleotide that corresponds to a nucleotide position of SEQ ID NO:1 that is not between positions 10354 and 16757.
[0017] In another embodiment the invention provides a method for determining a risk for or presence of altered bone mineral density in a subject, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism in a biological sample from a subject, said sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1, wherein the presence of at least one sclerostin gene region nucleotide polymorphism in the sample indicates an increased risk of altered bone mineral density, and wherein the polymorphism is not located at a nucleotide that corresponds to a nucleotide position of SEQ ID NO:1 that is selected from the group consisting of position 10357 and a trinucleotide insertion between positions 10565 and 10566.
[0018] In still another embodiment the invention provides method for determining a risk for or presence of altered bone mineral density in a first subject suspected of having or being at risk for having altered bone mineral density, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism that is associated with altered bone mineral density in each of a first and a second biological sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1, said first biological sample being obtained from said first subject and said second sample being obtained from a second subject known to be free of a risk or presence of altered bone mineral density, wherein the presence of at least one sclerostin gene region nucleotide polymorphism that is associated with altered bone mineral density in said first biological sample and the absence of said sclerostin gene region nucleotide polymorphism at a corresponding nucleotide in said second biological sample indicates an increased risk of altered bone mineral density, and wherein the polymorphism is not located at a nucleotide that corresponds to a nucleotide position of SEQ ID NO:1 that is selected from the group consisting of position 10357 and a trinucleotide insertion between positions 10565 and 10566.
[0019] According to another embodiment of the invention there is provided a method for determining a risk for or presence of altered bone mineral density in a first subject suspected of having or being at risk for having altered bone mineral density, comprising determining a presence or absence of at least one sclerostin gene region nucleotide polymorphism that is associated with altered bone mineral density in each of a first and a second biological sample comprising DNA having a sequence that corresponds to at least 50 consecutive nucleotides that are present in SEQ ID NO:1, said first biological sample being obtained from said first subject and said second sample being obtained from a second subject known to be free of a risk or presence of altered bone mineral density, wherein the presence of at least one sclerostin gene region nucleotide polymorphism that is associated with altered bone mineral density in said first biological sample and the absence of said sclerostin gene region nucleotide polymorphism at a corresponding nucleotide in said second biological sample indicates an increased risk of altered bone mineral density, and wherein the polymorphism is located at a nucleotide that corresponds to a nucleotide position of SEQ ID NO:1 that is not between positions 10354 and 16757. According to certain further embodiments of the above described methods, at least one sclerostin gene region nucleotide polymorphism is selected from a single nucleotide substitution at a nucleotide position in SEQ ID NO:1 that is selected from C4103G, C17966G, A18293G, T58083C, A74235G and A91068G
[0020] In certain other further embodiments of the above described methods, the presence in a sample from a female subject of at least one sclerostin gene region nucleotide polymorphism that is a GGA trinucleotide insertion between nucleotide positions 10565 and 10566 in SEQ ID NO:1 indicates an increased risk of decreased bone mineral density. In certain other further embodiments of the above described methods the step of determining comprises contacting at least one biological sample with at least one oligonucleotide primer having a nucleotide sequence that is complementary to a portion of a nucleic acid molecule having the sequence set forth in SEQ ID NO:1, under conditions and for a time sufficient to allow hybridization of said primer to the DNA. In certain further embodiments the method comprises detecting hybridization and extension of the oligonucleotide primer to produce a product, and therefrom determining the presence or absence of at least one sclerostin gene region nucleotide polymorphism. In certain other further embodiments of methods described above, the step of determining comprises contacting each of said first and second biological samples with an oligonucleotide primer having a nucleotide sequence that is complementary to a sequence present in the DNA of said first sample and present in the DNA of said second sample, under conditions and for a time sufficient to allow hybridization of said primer to the DNA; and detecting hybridization and extension of the primer to the DNA of the first sample to produce a first product and hybridization and extension of the primer to the DNA of the second sample to produce a second product distinguishable from said first product, and therefrom determining the presence or absence of at least one sclerostin gene region nucleotide polymorphism. According to certain further embodiments the DNA in the sample is amplified. According to certain other further embodiments the DNA in the first sample is amplified and the DNA in the second sample is amplified. According to certain other further embodiments the oligonucleotide primer comprises a nucleic acid molecule which comprises a nucleotide sequence set forth in a sequence selected from SEQ ID NOS:2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, 18, 23, 24, 26, 27, 29 and 30.
[0021] Turning to another aspect, the present invention provides an isolated polynucleotide comprising a sclerostin gene region polymorphism, the polynucleotide comprising a nucleotide sequence selected from (a) the sequence set forth in SEQ ID NO:1 and containing at least one sclerostin gene region nucleotide polymorphism, wherein said polymorphism is located at a nucleotide that corresponds to a nucleotide position of SEQ ID NO:1 that is selected from position 4103, 10357, 10566, 17966, 18293, 58083, 74235 and 91068, (b) the sequence set forth in SEQ ID NO:1 and containing a single nucleotide substitution at a position corresponding to a nucleotide position in SEQ ID NO:1 that is selected from C4103G, C10357T, C17966G, A18293G, T58083C, A74235G and A91068G, (c) the sequence set forth in SEQ ID NO:1 and containing a GGA trinucleotide insertion between nucleotide positions 10565 and 10566 in SEQ ID NO:1, (d) the sequence set forth in any one of SEQ ID NOS:4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 32 and 33, and (e) a sequence that is fully complementary to any sequence of (a)-(d).
[0022] In another embodiment the invention provides an isolated polynucleotide of at least 25 nucleotides comprising a polynucleotide sequence that corresponds to a portion of the nucleic acid sequence set forth in SEQ ID NO:1 in which at least one sclerostin gene region nucleotide polymorphism is present, wherein the polymorphism is located at a nucleotide that corresponds to a nucleotide position of SEQ ID NO:1 that is not between positions 10354 and 16757. In a further embodiment the sclerostin gene region nucleotide polymorphism is selected from (a) a single nucleotide substitution at a position corresponding to a nucleotide position in SEQ ID NO:1 that is selected from C4103G, C10357T, C17966G, A18293G, T58083C, A74235G and A91068G, and (b) a GGA trinucleotide insertion at a position corresponding to a nucleotide position in SEQ ID NO:1 that is between nucleotide positions 10565 and 10566. In another embodiment then invention provides an isolated polynucleotide comprising a nucleotide sequence selected from SEQ ID NOS:2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, 18, 23, 24, 26, 27, 29 and 30. In certain embodiments the invention provides an immobilized polynucleotide, comprising any of the above described polynucleotides coupled to a solid support, and in certain other embodiments the invention provides a nucleic acid array comprising a plurality of such isolated nucleic acid molecules immobilized on a solid support. In another embodiment there is provided a kit for identifying a sclerostin gene region polymorphism, comprising any of the above-described isolated polynucleotides and an ancillary reagent.
[0023] In another embodiment the invention provides a method of stratifying human subjects according to sclerostin gene region polymorphisms, comprising determining presence or absence of at least one sclerostin gene region polymorphism in a biological sample obtained from each of a plurality of subjects, wherein (i) presence or absence of a sclerostin gene region polymorphism indicates altered bone mineral density, and (ii) the polymorphism is located at a nucleotide that corresponds to a nucleotide position of SEQ ID NO:1 that is not between positions 10354 and 16757, and therefrom stratifying said subjects. In a further embodiment the sclerostin gene region polymorphism is selected from (a) a single nucleotide substitution at a position corresponding to a nucleotide position in SEQ ID NO:1 that is selected from C4103G, C10357T, C17966G, A18293G, T58083C, A74235G and A91068G, and (b) a GGA trinucleotide insertion at a position corresponding to a nucleotide position in SEQ ID NO:1 that is between nucleotide positions 10565 and 10566. In certain further embodiments the method comprises determining gender of each subject, wherein the presence of at least one gender-associated sclerostin gene region nucleotide polymorphism indicates an increased risk of altered bone mineral density, and in certain still further embodiments the gender-associated sclerostin gene region nucleotide polymorphism is selected from (a) a GGA trinucleotide insertion at a position corresponding to a nucleotide position in SEQ ID NO:1 that is between nucleotide positions 10565 and 10566, presence of which in a female subject indicates an increased risk of decreased bone mineral density, and (b) an A-to-G substitution at a position corresponding to nucleotide position 91068 in SEQ ID NO:1, presence of which in a male subject indicates an increased risk of increased bone mineral density.
[0024] Accordingly, the present invention provides nucleotide sequences that are associated with polymorphisms in the SOST gene region. Sequences associated with these nucleotide polymorphisms include SEQ ID NOs: 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 32 and 33 as identified herein. As described in greater detail below, diseases and/or conditions associated with bone density can be detected and/or predicted by the methods of the current invention using nucleotide sequences disclosed herein. Exemplary diseases and/or conditions include without limitation, osteopenia, osteoporosis and gum diseases.
[0025] These and other aspects of the present invention will become evident upon reference to the following detailed description and attached drawings. In addition, various references are set forth herein which describe in more detail certain aspects of this invention, and are therefore incorporated by reference in their entireties as if fully set forth herein.



BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING(S)
[0026]FIG. 1 shows that the effect of the genotypes associated with bone density strongly increase with age.


BRIEF DESCRIPTION OF THE SEQUENCE IDENTIFIERS
[0027] SEQ ID NO:1 sets forth the DNA sequence of the SOST gene region, including the SOST gene body and extended flanking sequence.
[0028] SEQ ID NO:2 sets forth the DNA sequence for the forward primer used in the detection of the SRP1 polymorphism.
[0029] SEQ ID NO:3 sets forth the DNA sequence for the reverse primer used in the detection of the SRP1 polymorphism.
[0030] SEQ ID NO:4 sets forth the DNA sequence corresponding to the SRP1 polymorphism.
[0031] SEQ ID NO:5 sets forth the DNA sequence for the forward primer used in the detection of the SRP2 polymorphism.
[0032] SEQ ID NO:6 sets forth the DNA sequence for the reverse primer used in the detection of the SRP2 polymorphism.
[0033] SEQ ID NO:7 sets forth the DNA sequence corresponding to the SRP2 polymorphism.
[0034] SEQ ID NO:8 sets forth the DNA sequence for the forward primer used in the detection of the SRP3 polymorphism.
[0035] SEQ ID NO:9 sets forth the DNA sequence for the reverse primer used in the detection of the SRP3 polymorphism.
[0036] SEQ ID NO:10 sets forth the DNA sequence corresponding to the SRP3 polymorphism.
[0037] SEQ ID NO:11 sets forth the DNA sequence for the forward primer used in the detection of the alternative SRP2+SRP3 polymorphism.
[0038] SEQ ID NO:12 sets forth the DNA sequence for the reverse primer used in the detection of the alternative SRP2+SRP3 polymorphism.
[0039] SEQ ID NO:13 sets forth the DNA sequence corresponding to the alternative SRP2+SRP3 polymorphism.
[0040] SEQ ID NO:14 sets forth the DNA sequence for the forward primer used in the detection of the SRP5 polymorphism.
[0041] SEQ ID NO:15 sets forth the DNA sequence for the reverse primer used in the detection of the SRP5 polymorphism.
[0042] SEQ ID NO:16 sets forth the DNA sequence corresponding to the SRP5 polymorphism.
[0043] SEQ ID NO:17 sets forth the DNA sequence for the forward primer used in the detection of the SRP6 polymorphism.
[0044] SEQ ID NO:18 sets forth the DNA sequence for the reverse primer used in the detection of the SRP6 polymorphism.
[0045] SEQ ID NO:19 sets forth the DNA sequence corresponding to the SRP6 polymorphism.
[0046] SEQ ID NO:20 sets forth the DNA sequence for the forward primer used in the detection of the alternate SRP5+SRP6 polymorphism.
[0047] SEQ ID NO:21 sets forth the DNA sequence for the reverse primer used in the detection of the alternate SRP5+SRP6 polymorphism.
[0048] SEQ ID NO:22 sets forth the DNA sequence corresponding to the alternate SRP5+SRP6 polymorphism.
[0049] SEQ ID NO:23 sets forth the DNA sequence for the forward primer used in the detection of the SRP7 polymorphism.
[0050] SEQ ID NO:24 sets forth the DNA sequence for the reverse primer used in the detection of the SRP7 polymorphism.
[0051] SEQ ID NO:25 sets forth the DNA sequence corresponding to the SRP7 polymorphism.
[0052] SEQ ID NO:26 sets forth the DNA sequence for the forward primer used in the detection of the SRP8 polymorphism.
[0053] SEQ ID NO:27 sets forth the DNA sequence for the reverse primer used in the detection of the SRP8 polymorphism.
[0054] SEQ ID NO:28 sets forth the DNA sequence corresponding to the SRP8 polymorphism.
[0055] SEQ ID NO:29 sets forth the DNA sequence for the forward primer used in the detection of the SRP9 polymorphism.
[0056] SEQ ID NO:30 sets forth the DNA sequence for the reverse primer used in the detection of the SRP9 polymorphism.
[0057] SEQ ID NO:31 sets forth the DNA sequence corresponding to the SRP9 polymorphism.
[0058] SEQ ID NO:32 is an alternative sequence for the SRP3 polymorphism.
[0059] SEQ ID NO:33 is an alternative sequence for the SRP2+SRP3 polymorphism.
[0060] SEQ ID NO:34 presents the human chromosome 17 sequence set forth in EMBL Acc. No. AC003098.
DETAILED DESCRIPTION OF THE INVENTION
[0061] The present invention relates to the unexpected discovery of specific nucleotide polymorphisms in the sclerostin gene region of human chromosome 17. More specifically, the invention relates to the surprising determination of sclerostin gene region nucleotide polymorphisms (SRP) in non-protein coding regions of the sclerostin gene region, including SRP the presence of which in a DNA sample from a subject correlates with an increased likelihood that the subject has, or is at risk for having, altered (e.g., increased or decreased in a statistically significant manner relative to a control subject) bone mineral density. The invention is thus directed generally to compositions and methods for diagnosing the risk or presence of altered bone mineral density (BMD) in a subject, and to compositions and methods for the identification of agents that may be suitable for treating diseases, disorders or other conditions associated with altered BMD (i.e., BMD that is increased or decreased in a statistically significant manner relative to normal control BMD levels). The invention may be useful for pharmacogenomic purposes, for example to stratify patient populations according to the suitability of particular therapeutic agents for use in such populations.
[0062] As also discussed above, “altered bone mineral density” may refer to any condition or state, including those that accompany a disease, where any structure or activity that is directly or indirectly related to formation and/or maintenance of bone mass has been changed in a statistically significant manner. Altered BMD may have its origin in cells and tissues (or their products) that are proximately involved in bone formation and maintenance as well as in cells and tissues (or their products) acting from distal sites to regulate bone formation or maintenance, in direct interactions between genes and/or gene products of such cells and tissues, or in structural or functional changes that occur as the result of interactions between intermediates that may be formed as the result of such interactions, including metabolites, catabolites, substrates, precursors, cofactors and the like.
[0063] According to the present invention, determination or detection of one or more sclerostin gene region polymorphisms provide a novel and useful parameter for diagnosing the risk or presence of altered BMD in a subject, and for identifying agents that may be suitable for treating altered BMD. As discussed above and in, e.g., U.S. Pat. Nos. 6,395,511, 6,489,445, and 6,495,736, a number of conditions are associated with alterations in BMD. Further, detection of an appropriate parameter can provide preclinical evidence for a risk of or predisposition to a disease or disorder that is characterized by altered BMD. In particular, and according to non-limiting theory, in certain embodiments the invention contemplates determining in a subject at a relatively early age an increased risk, predisposition, likelihood or the like of the occurrence of altered BMD in the subject, even where such altered BMD may not manifest itself until the subject has attained a relatively advanced age, which may be an age greater than 30, 35, 40, 45, 50, 55, 60, 65 or more years.
[0064] A “sclerostin gene region” includes the area of human chromosome 17 that contains the polynucleotide sequence set forth in SEQ ID NO:1. According to the present invention there are provided compositions and methods that derive from the unexpected identification of nucleotide polymorphisms in the genomic DNA of the sclerostin gene region. In particular, there are provided a number of such sclerostin gene region nucleotide polymorphisms (SRPs), which include polymorphisms in non-coding regions of SEQ ID NO:1 (e.g., segments or portions of SEQ ID NO:1 that are comprised of polynucleotide sequences which do not encode the amino acid sequences that comprise a sclerostin polypeptide, such as the sclerostin polypeptides described in U.S. Pat. No. 6,489,445 and referred to therein as “Beer” proteins). As described in greater detail herein, the occurrence of certain SRPs in a sample from a subject can be correlated with (e.g., shown with statistical significance to indicate) an increased risk for altered BMD in the subject. Expressly excluded from certain preferred embodiments of the invention are sclerostin gene region nucleotide polymorphisms that are located at a nucleotide that corresponds to a nucleotide position that is between positions 10354 and 16757 of SEQ ID NO:1. Expressly excluded from certain other preferred embodiments of the invention are sclerostin gene region nucleotide polymorphisms that are located at a nucleotide that corresponds to nucleotide position 10357 of SEQ ID NO:1, or that corresponds to a trinucleotide insertion between positions 10565 and 10566 of SEQ ID NO:1. Also excluded from certain preferred embodiments of the invention are sclerostin gene region nucleotide polymorphisms that are located at a nucleotide that corresponds to position 6136, 6140 and/or 9047 of EMBL Accession No. AC003098 [SEQ ID NO:34] (see, e.g., WO 01/98491), and to nucleotide positions 15095, 15091 and 12184 of SEQ ID NO:1.
[0065] Determination of a sclerostin gene region polymorphism may involve strong but not necessarily absolute nucleotide sequence conservation when corresponding portions of sclerostin gene region DNA in a sample from a subject suspected of having or being at risk for having altered BMD, and sclerostin gene region DNA in a sample from a subject known to be free of such risk, are compared, as discussed herein. The invention provides compositions and methods that include the use of nucleic acid molecules, or portions thereof, having nucleotide sequences that are found in the human DNA sequence set forth in SEQ ID NO:1 and fragments of SEQ ID NO:1 that are suitable for use as oligonucleotide primers in nucleic acid primer extension or amplification techniques, as hybridization probes for the detection of complementary nucleotide sequences in a sample or for any number of additional uses that are well known to those familiar with the art. According to the various embodiments described herein, DNA may be nuclear DNA, including chromosomal and non-chromosomal DNA, which in preferred embodiments comprises all or a portion of a sclerostin gene region.
[0066] Nucleic acid sequences within the scope of the invention include isolated DNA and RNA sequences that specifically hybridize under conditions of moderate or high stringency to DNA nucleotide sequences such as those found in SEQ ID NO:1, including specific DNA sequences disclosed herein or fragments thereof, and their complements. As used herein, conditions of moderate stringency, as known to those having ordinary skill in the art, and as defined by Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd Ed. Vol. 1, pp. 1.101-104, Cold Spring Harbor Laboratory Press (1989), include use of a prewashing solution for the nitrocellulose filters 5×SSC, 0.5% SDS, 1.0 mM EDTA (pH 8.0), hybridization conditions of 50% formamide, 6×SSC at 42° C. (or other similar hybridization solution), and washing conditions of about 50-60° C., 0.5×SSC, 0.1% SDS. Conditions of high stringency are defined as hybridization conditions as above, and with washing at 60-68° C., 0.2×SSC, 0.1% SDS. In other embodiments, hybridization to a DNA nucleotide sequence may be at normal stringency, which is approximately 25-30° C. below Tm of the native duplex (e.g., 5×SSPE, 0.5% SDS, 5× Denhardt's solution, 50% formamide, at 42° C. or equivalent conditions), at low stringency hybridizations, which utilize conditions approximately 40° C. below Tm, or at high stringency hybridizations, which utilize conditions approximately 10° C. below Tm. The skilled artisan will recognize that the temperature, salt concentration, and chaotrope composition of hybridization and wash solutions may be adjusted as necessary according to factors such as the length and nucleotide base composition of the probe. (See also, e.g., Ausubel et al., Current Protocols in Molecular Biology , Greene Publishing, 1987.) As also known to those having ordinary skill in the art, variations in stringency of hybridization conditions may be achieved by altering the time, temperature and/or concentration of the solutions used for prehybridization, hybridization and wash steps, and suitable conditions may also depend in part on the particular nucleotide sequences of the probe used, and of the blotted, proband nucleic acid sample. Accordingly, it will be appreciated that suitably stringent conditions can be readily selected without undue experimentation where a desired selectivity of the probe is identified, based on its ability to hybridize to one or more certain proband sequences while not hybridizing to certain other proband sequences.
[0067] An “isolated nucleic acid molecule” refers to a polynucleotide molecule in the form of a separate fragment or as a component of a larger nucleic acid construct, that has been separated from its source cell (including the chromosome it normally resides in) at least once, preferably in a substantially pure form. Isolated nucleic acids may be nucleic acids having particular disclosed nucleotide sequences or may be regions, portions or fragments thereof. Those having ordinary skill in the art are able to prepare isolated nucleic acids having the complete nucleotide sequence, or the sequence of any portion of a particular isolated nucleic acid molecule, when provided with the appropriate nucleic acid sequence information as disclosed herein. Nucleic acid molecules may be comprised of a wide variety of nucleotides, including DNA, RNA, nucleotide analogues such as phosphorothioates or peptide nucleic acids, or other analogues with which those skilled in the art will be familiar, or some combination of these.
[0068] In one embodiment, known DNA sequences derived from SEQ ID NO:1 may be utilized to design oligonucleotide primers or hybridization probes suitable for screening genomic libraries. Preferably, such oligonucleotide primers or probes are 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31-35, 36-40, 41-50, 51-60, 61-75 or more bases in length and have sequences that, under the hybridization conditions selected, hybridize to complementary DNA sequences lacking nucleotide substitutions, insertions, duplications or deletions (“polymorphisms” or “mutations”) relative to the corresponding region of the DNA sequence of SEQ ID NO:1.
[0069] Portions of a polymorphic DNA sequence (or of an oligonucleotide primer or probe) and the DNA sequence of SEQ ID NO:1 are regarded as “corresponding” nucleic acid sequences, regions, fragments or the like, based on the convention for numbering DNA nucleic acid positions according to SEQ ID NO:1, wherein a candidate polymorphic DNA sequence (or primer or probe) is aligned with the DNA sequence of SEQ ID NO:1 such that at least 70%, preferably at least 80% and more preferably at least 90% of the nucleotides in a given sequence of at least 18-20 consecutive nucleotides of a sequence are identical. In certain preferred embodiments, a polymorphic DNA sequence is greater than 95% identical to a corresponding DNA sequence that is present in SEQ ID NO:1. In certain particularly preferred embodiments, an oligonucleotide primer or probe, or a region of a polymorphic DNA sequence that lacks any polymorphisms, is identical to a corresponding portion of SEQ ID NO:1. Those oligonucleotide probes having sequences that are identical in corresponding regions of SEQ ID NO:1 may be identified and selected following hybridization target DNA sequence analysis, to verify the absence of mutations in the target DNA sequence.
[0070] DNA containing one or more sclerostin gene region polymorphisms may be isolated from genomic DNA, typically by first generating an appropriate DNA library through techniques for constructing libraries that are known in the art (see Sambrook et al., Molecular Cloning: A Laboratory Manual , Cold Spring Harbor Press, 1989) or purchased from commercial sources (e.g., Clontech, Palo Alto, Calif.). Briefly, genomic DNA libraries can be constructed in chromosomal vectors, such as YACs (yeast artificial chromosomes), bacteriophage vectors, such as pBeloBAC11, λEMBL3, λgt10, cosmids, or plasmids. Alternatively, isolated DNA may be prepared by preferentially amplifying sclerostin gene region DNA sequences present in biological samples using, for example, DNA amplification methodologies such as PCR or other amplification techniques that are well known in the art, with suitable oligonucleotide primers complementary to such DNA sequences as disclosed herein. To facilitate hybridization detection, the oligonucleotide may be conveniently labeled, generally at the 5′ end, with a reporter molecule, such as a radionuclide, e.g., 32 P, enzymatic label, protein label, fluorescent label, biotin or other suitable labeling moieties known in the art.
[0071] Such libraries are then generally plated as phage or colonies, depending upon the vector used. Subsequently, a plate replica to which the colonies or phage have been transferred, such as a nitrocellulose or nylon membrane or the like, is probed to identify candidate clones that contain the polymorphic sclerostin gene region DNA sequence. Such candidates may be verified as containing such polymorphisms by any of various means including, for example, DNA sequence analysis or hybridization with a second, non-overlapping probe selected as described above to hybridize with target DNA sequences lacking nucleotide substitutions, deletions, duplications or insertions relative to the corresponding portion of the DNA sequence of SEQ ID NO:1.
[0072] Once a library is identified as containing DNA having at least one scleorstin gene region polymorphism, the polymorphic DNA can be isolated by amplification. Briefly, when using genomic library DNA as a template, amplification primers are designed based upon a DNA sequence that has been determined (e.g., SEQ ID NO:1) and primer “walking” is used to select primers that anneal to DNA regions within such sequences. The primers preferably have a GC content of about 50% and contain restriction sites to facilitate cloning. Primers typically do not have self-complementary sequences, nor do they contain complementary sequences at their 3′ end (to prevent primer-dimer formation). The primers are annealed to genomic DNA and sufficient amplification cycles are performed to yield a product readily visualized by gel electrophoresis and staining. The amplified fragment is purified and inserted into a vector, such as λgt10 or pBS(M13+), and propagated. Confirmation of the nature of the fragment is obtained by DNA sequence analysis.
[0073] Oligonucleotide primers or probes as described above for use in isolating polymorphic sclerostin gene region DNA from genomic DNA may also be useful in the present invention for determining the presence of a sclerostin gene region nucleotide polymorphism by any of a variety of techniques well known in the art for determining the amount of specific nucleic acid target sequences present in a sample based on specific hybridization of a primer to the target sequence. Optionally, in certain of these techniques, hybridization precedes nucleotide polymerase catalyzed extension of the primer using the strand containing the target sequence as a template, and/or ligation of oligonucleotides hybridized to adjacent target sequences, and embodiments of the invention using primer extension are particularly preferred. For examples of references on such quantitative detection techniques, including those that may be used to detect nucleotide insertions, substitutions, duplications or deletions in a portion of a sclerostin gene region DNA sequence site near an oligonucleotide primer target hybridization site that corresponds to a portion of the DNA sequence of SEQ ID NO:1, and further including those that involve primer extension, see, for example, Kuppuswamy et al. (Proc. Nat. Acad. Sci. USA 88:1143,1991), Botstein et al. ( Am. J. Hum. Gen. 32:314,1980), Gibbs et al. ( Nucl. Ac. Res. 17:2437, 1989), Newton et al. ( Nucl. Ac. Res. 17:2503, 1989), Syvanen et al., ( Genomics 8:684, 1990), Grossman et al. ( Nucl. Ac. Res. 22:4527, 1994), and Saiki et al. ( Proc. Nat. Acad. Sci. 86:6230, 1989), all of which are hereby incorporated by reference.
[0074] A particularly useful method for this purpose is the primer extension assay disclosed by Krook et al. ( Hum. Molec. Genet. 1:391, 1995) which teaches modification of primer extension reactions to detect multiple nucleotide substitutions, insertions, deletions or other mutations. Other examples of useful techniques for quantifying the presence of specific nucleic acid target sequences in a sample include but need not be limited to labeled probe hybridization to the target nucleic acid sequences with or without first partially separating target nucleic acids from other nucleic acids present in the sample.
[0075] Examples of other useful techniques for determining the amount of specific nucleic acid target sequences (e.g., a target sequence containing a polymorphism such as a sclerostin gene region polymorphism as provided herein) present in a sample based on specific hybridization of a primer to the target sequence include specific amplification of target nucleic acid sequences and quantification of amplification products, including but not limited to polymerase chain reaction (PCR, Gibbs et al., Nucl. Ac. Res. 17:2437, 1989), transcriptional amplification systems, strand displacement amplification and self-sustained sequence replication (3SR, Gingeras et al., J. Infect. Dis. 164:1066,1991), the cited references for which are hereby incorporated in their entireties. Examples of other useful techniques include ligase chain reaction (e.g., Landegren et al., Science 241:1077, 1988; Nickerson et al., Proc. Natl. Acad. Sci. USA 87:8923 1990; Barany, Proc. Natl. Acad. Sci. USA 88:189,1991; Wu et al., Genomics 4:560,1989), single stranded conformational polymorphism analysis, Q-beta replicase assay, restriction fragment length polymorphism (RFLP, Botstein et al., Am. J. Hum. Gen. 32:314, 1980) analysis, cycled probe technology and solid-phase DNA-binding assays such as those disclosed in U.S. Pat. No. 6,340,566, as well as other suitable methods that will be known to those familiar with the art.
[0076] Sequence length or molecular mass of polynucleotides, for example, primer extension assay products containing sclerostin gene region polymorphisms, may be determined using any known method for characterizing the size of nucleic acid sequences with which those skilled in the art are familiar. In a preferred embodiment, such products are characterized by capillary electrophoresis. In another preferred embodiment, primer extension products are characterized by mass spectrometry (MS), which may further include matrix assisted laser desorption ionization/time of flight (MALDI-TOF) analysis or other MS techniques known to those having skill in the art. See, for example, U.S. Pat. No. 5,622,824, U.S. Pat. No. 5,605,798 and U.S. Pat. No. 5,547,835. In another preferred embodiment, primer extension products are characterized by liquid or gas chromatography, which may further include high performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS) or other well known chromatographic methodologies.
[0077] Also contemplated according to the compositions and methods of the present invention are uses of the isolated nucleic acid molecules described herein as immobilized polynucleotides, which may include a polynucleotide that is covalently or non-covalently coupled to a solid support. Coupling chemistries and selection of support materials are well known in the art, and such supports may include supports made of glass, silica, metal, plastic, fiber, resin, polymers and the like, including for example cellulose, nitrocellulose, polyacetate, polycarbonate, polystyrene, polyester, polyvinyldifluorobenzene, nylon, carbon fiber or any other suitable solid material for the intended use and with which those skilled in the art will be familiar. In certain related embodiments one or a plurality of the nucleic acid molecules described herein may be provided as an array immobilized on a solid support, which includes any of a number of well known configurations for spatially arranging such polynucleotides in an identifiable (e.g., addressable) fashion. The skilled artisan will be familiar with various compositions and methods for making and using arrays of such solid-phase immobilized nucleic acid arrays. In certain other related embodiments the invention contemplates a kit for identifying a scloerostin gene region polymorphism as provided herein, which kit comprises an isolated polynucleotide as described herein (including solid phase immobilized nucleic acid molecules) and an ancillary reagent such as appropriate buffers, wash solutions, indicators, detection media and the like, depending on the particular assay configuration to be practiced.
[0078] As used herein, DNA sequence variability refers to the DNA sequence variation between one DNA sequence and a second DNA sequence. Either the first or the second DNA sequence may be a reference or control sequence such as a wild type sequence. Thus, DNA sequence variability is, for example, the differences in the DNA sequence between the reference or control sequence and another sequence of interest. As used herein, differences between two DNA sequences of interest may be identified by hybridization under conditions which permit base pairing between the two strands. When the hybrid formed between the two strands contains mismatches, then the two DNA sequences contain one or more differences in their base sequences.
[0079] As referred to herein, a nucleotide polymorphism represents a change in the DNA sequence from a normal sequence or wild type sequence to a mutated or different sequence. Nucleotide polymorphisms of the current invention can include genetic mutations, single base pair mutations, DNA mismatches, DNA insertions, DNA deletions, DNA transversions, frameshift mutations, damaged DNA, DNA duplications and or other alterations in a normal or wild type DNA sequence. As referred to herein, a single nucleotide polymorphism (SNP) refers to a nucleotide polymorphism which is a single nucleotide variation in the genetic sequence of an organism relative to a standard sequence. It is estimated that the average human will have a SNP every 1000 base pairs (there are ca. 3 billion base pairs in the human genome). Many SNPs are nonconsequential; however, some may render the organism prone to disease.
[0080] In one embodiment, the present invention provides nucleotide sequences that are associated with SOST gene region polymorphisms (SRP). Sequences associated with these nucleotide polymorphisms include SEQ ID NOs: 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 32 and 33 as identified herein.
[0081] In another embodiment of the invention, diseases and/or conditions associated with bone density can be detected and/or predicted by the methods of the current invention using nucleotide sequences as identified herein. Exemplary diseases and/or conditions include without limitation, osteopenia, osteoporosis and gum diseases.
[0082] As described herein, the present invention provides compositions and methods related to novel polymorphic sclerostin gene region DNA sequences that may differ from known DNA sequences at one or more nucleotide positions as disclosed herein, for example, the SRPs 1-3 and 5-9 described in the Examples and Sequence Listing, and the DNA sequences of SEQ ID NOS:4, 7, 10, 13, 16, 19, 22, 25, 28, and 31-33. Details for obtaining SEQ ID NO:1 are provided below in the Examples. Those having ordinary skill in the art can also readily obtain other isolated sclerostin gene region DNA sequences using well known methodologies including those provided herein and in the cited references, and further including the use of the oligonucleotide primers provided in the Examples. Databases (e.g., GenBank, EMBL) and methods for nucleic acid sequence analysis are also well known in the art, for example, similarity between two sequences may be readily determined using well known computer programs such as the BLAST algorithm (Altschul, J. Mol. Biol. 219:555-565, 1991; Henikoff and Henikoff, Proc. Natl. Acad. Sci. USA 89:10915-10919, 1992), which is available at the NCBI website (http://www/ncbi.nlm.nih.gov/cgi-bin/BLAST). Default parameters may be used. Examples of other useful computer algorithms are those used in programs such as Align and FASTA, which may be accessed, for example, at the Genestream internet website of the Institut de Genetique Humaine, Montpellier, France (www2.igh.cnrs.fr/home.eng.html) and used with default parameters.
[0083] In another particularly preferred embodiment of the invention, sclerostin gene region DNA in a biological sample containing DNA is first amplified by methodologies well known in the art and described herein, such that the amplification products may be used as templates in a method for determining the presence or absence of at least one sclerostin gene region nucleotide in the sample.
[0084] Biological samples containing DNA which comprises a sclerostin gene region may comprise any tissue or cell preparation in which genomic DNA may be present. In preferred embodiments such samples comprise DNA having a nucleotide sequence that corresponds to at least 20, 30, 40, 50, 60, 70, 80, 90, 100, 101-200 or more consecutive nucleotides that are present in SEQ ID NO:1, and in other preferred embodiments such samples may comprise DNA having a nucleotide sequence that corresponds to at least 200-500, 501-1,000, 1,000-5,000, 5,001-10,000 or more consecutive nucleotides that are present in SEQ ID NO:1. Biological samples may be provided by obtaining a blood sample, biopsy specimen, tissue explant, organ culture or any other tissue or cell preparation from a subject or a biological source. The subject or biological source may be a human or non-human animal, a primary cell culture or culture adapted cell line including but not limited to genetically engineered cell lines that may contain chromosomally integrated or episomal recombinant nucleic acid sequences, immortalized or immortalizable cell lines, somatic cell hybrid cell lines, differentiated or differentiatable cell lines, transformed cell lines and the like. In certain preferred embodiments of the invention, the subject or biological source may be suspected of having or being at risk for having altered BMD, and in certain preferred embodiments of the invention the subject or biological source may be known to be free of a risk or presence of such a condition.
[0085] In certain other preferred embodiments where it is desirable to determine whether or not a subject or biological source falls within clinical parameters indicative of altered BMD, signs and symptoms of altered BMD that are accepted by those skilled in the art may be used to so designate a subject or biological source, for example clinical signs referred to in Jouanny et al. (1995 Arthritis Rheum. 38:61), Melton (1997 Fourth International Symposium: Osteoporosis ; National Osteoporosis Foundation, Washington, D.C., p. 23), Consensus Development Conference: Diagnosis, prophylaxis and treatment of osteoporosis (1993 Am. J. Med. 94:646-650), Eisman (2000 Endocr. Rev. 20:788) and references cited therein, or other means known in the art for diagnosing conditions, diseases or disorders associated with altered BMD such as those described herein.
[0086] The present invention also provides compositions and methods that are useful in pharmacogenomics, for the classification and/or stratification of a subject or a patient population, for instance correlation of one or more traits in a subject with indicators of the responsiveness to, or efficacy of, a particular therapeutic treatment. In certain embodiments of the invention, determination of the presence of at least one sclerostin gene region nucleotide polymorphism in a biological sample from a subject is combined with identification of the subject's gender to determine the risk for, or presence of, altered BMD in the subject. According to such embodiments, and without wishing to be bound by theory, certain sclerostin gene region nucleotide polymorphisms described herein can be correlated with an increased risk for altered BMD as a factor of the subject's gender, and may therefore be referred to as “gender-associated” sclerostin gene region nucleotide polymorphisms. For instance, and as described in greater detail in the Examples, the presence of the sclerostin gene region nucleotide polymorphism SRP3 in female subjects indicated a presence, or risk of having, increased BMD. As also described in the Examples, the presence of the sclerostin gene region nucleotide polymorphism SRP9 in male subjects indicated a presence, or risk of having, decreased BMD. Accordingly, and without wishing to be bound by theory, the invention contemplates gender-specific associations and/or correlations of particular sclerostin gene region nucleotide polymorphisms with altered BMD.
[0087] As described herein, determination of at least one sclerostin gene region nucleotide polymorphism may be used to stratify a patient population that includes individuals suspected of having or being at risk for having altered BMD. Accordingly, in another preferred embodiment of the invention, determination of one or more such polymorphisms in a biological sample containing DNA from such subjects may provide a useful correlative indicator for that subject. A subject so classified on the basis of one or more particular sclerostin gene region nucleotide polymorphisms may then be monitored using BMD clinical parameters referred to above, such that correlation between polymorphisms and any particular clinical score used to evaluate BMD may be monitored. For example, stratification of a patient population according to sclerostin gene region polymorphisms (SRPs) disclosed herein may provide a useful marker with which to correlate the efficacy of any candidate therapeutic agent being used in subjects having altered BMD. In a further preferred embodiment of this aspect of the invention, determination of one or more SRPs in concert with determination of a subject's gender may also be useful, as discussed in greater detail herein. These and related advantages will be appreciated by those familiar with the art.
[0088] The following Examples are provided by way of illustration and not limitation.
EXAMPLES
Example 1
Method for Identifying Individuals Susceptible to Developing Osteoporosis
[0089] Natural variants in the human SOST gene region were identified by sequencing ˜90 kb of genomic DNA from a panel of 90 ethnically diverse individuals from the NIGMS Human Variation Collection, panel HD01-HD09. Eight polymorphisms (SRP1-3 and SRP5-9) spanning a total of ˜87 kb were chosen to genotype 1,927 men and women aged 55-80 years from a large population-based prospective cohort study of elderly Dutch Caucasians ( Eur. J. Epidem., 1991, 7:403-422). Genomic DNA was obtained from peripheral blood of each individual by conventional methods. For each polymorphism genotyping assay, 10 ng of genomic DNA were used in a polymerase chain reaction (PCR) with oligonucleotide primers located on either side of the polymorphism.
[0090] Genomic DNA was extracted from samples of peripheral venous blood according to standard procedures. Polymorphism-containing regions were amplified from genomic DNA with the polymerase chain reaction (PCR). Each PCR was carried out in a 10 μl reaction volume containing 5 ng of genomic-DNA, 1.5 mM magnesium chloride, 0.2 mM deoxy-NTP, 2 pmol of each primer (see below), 0.2 units of Taq polymerase (Promega) and 10×PCR buffer (Promega) containing 20 mM Tris-HCl (pH 8.0), 100 mM KCl, 0.1 mM EDTA, 1 mM DDT, 50% glycerol, 0.5% Nonidet®-P40 and 0.5% Tween®20. The reactions were performed in a 384-wells thermocycler (MJ Research Tetrad) with different cycling protocols for each amplicon (37 cycles, Tm=53° C. for SRPs 8 and 9, Tm=55° C. for SRPs 1, 2-3 and 7, Tm=60° C. for SRPs 5-6). The genotypes were detected by the Single Base Extension (SBE) procedure using SBE primers of different lengths (Table 1). The SBE reactions were performed according to details provided by the manufacturer (ABI Prism® SNaPsho™ Multiplex Kit) with slight modifications. The genotypes thus generated were analyzed with the software program called Genotyper 3.7 (Applied Biosystems) and also checked by eye. To confirm the accuracy of the genotyping, 150 randomly selected samples were genotyped for a second time with the same method. No discrepancies were found.
TABLE 1 SOST REGION POLYMORPHISMS (SRP) AND PRIMERS FOR SBE GENOTYPING Position No. SRP# SEQ ID NO:1 PCR primers (5′-3′) SBE primers (5′-3′) SRP1 C4103G a Fd CTTTCCACAGGCTCGTCT (T) 4 GAAGGTAGCGCCACCTGCTG Rv CTCTCAACCGGAAATGTCT SRP2 C10357T a Fd AGGTGGGGCTATAAGCATCCATCC (T) 10 TTGTGAGAAGCTGGCCCTCC Rv GTCCTTTCCCACCTGCCTCAACTT SRP3 10565insGGA a (T) 16 ATGATGGATGATGGAAAGGA SRP5 C17966G a Fd TAAGGTGGGATGCTCAACTCG (T) 22 TAGTGGTAGTTAAACTGACAA Rv CAGGAGAATCACTTGAATCCG SRP6 A18293G a (T) 28 AAGTTGCAGTAAGCCGAGAT SRP7 T58083C b Fd CCCTACCTTACTGTCCGCCTCTCA (T) 34 TTTAGTATAAAAGCTGGCTC Rv GTGCTACCTCTCGGGAAAACATAA SRP8 A74235G b Fd GAGCAACCGGCGTATCC (T) 40 TTTATAGTTCTTTCCTAGAC Rv GGGGTTTCTTTCTGGCTCTCA SRP9 A91068G b Fd CCAGCAATGTTGAGGAAT (T) 46 CTGCTCAGCAAGCAGTTCCA Rv CGCAGGAAGGTGTGGAGA

[0091] In the case of SRP2 and 3, and SRP5 and 6, the polymorphisms were close enough together that the primary PCR could be performed using primers flanking the pair of polymorphisms. In general, primers were designed to amplify fragments of 150-500 base pairs (bp) in length. Specific alleles at each site were determined by a single-base extension (SBE) assay, using the Applied Biosystems (ABI, Foster City, Calif.) SNAPshot™ kit reagents and oligonucleotide design protocol according to the supplier's recommendations. Products of the SBE were pooled, then resolved and detected on a capillary electrophoresis instrument (ABI 3100). Standard statistical methods were used to determine whether particular alleles were associated with high or low bone density.
[0092] The SRP1 polymorphism was identified using the SRP1 forward and reverse primer pair (SEQ ID NOs:2 and 3). The amplicon generated using this primer pair is disclosed in SEQ ID NO:4. This sequence identifies the SRP1 polymorphism at nucleotide position 4103 of SEQ ID NO:1. This specific polymorpism involves the substitution of a C to a G.
[0093] The SRP2 polymorphism was identified using the SRP2 forward and reverse primer pair (SEQ ID NOs:5 and 6). The amplicon generated using this primer pair is disclosed in SEQ ID NO:7. This sequence identifies the SRP2 polymorphism at nucleotide position 10357 of SEQ ID NO:1. This specific polymorpism involves the substitution of a C to a T.
[0094] The SRP3 polymorphism was identified using the SRP3 forward and reverse primer pair (SEQ ID NOs:8 and 9). The amplicon generated using this primer pair is disclosed in SEQ ID NOs:10 and 32. This sequence identifies the SRP3 polymorphism at nucleotide position 10566 of SEQ ID NO:1. This specific polymorpism involves either the inclusion (or deletion) of nucleotides GGA as a trinucleotide insertion (or deletion) between positions 10565 and 10566 of SEQ ID NO:1.
[0095] The SRP5 polymorphism was identified using the SRP5 forward and reverse primer pair (SEQ ID NOs:14 and 15). The amplicon generated using this primer pair is disclosed in SEQ ID NO:16. This sequence identifies the SRP5 polymorphism at nucleotide position 17966 of SEQ ID NO:1. This specific polymorpism involves the substitution of a C to a G.
[0096] The SRP6 polymorphism was identified using the SRP6 forward and reverse primer pair (SEQ ID NOs:17 and 18). The amplicon generated using this primer pair is disclosed in SEQ ID NO:19. This sequence identifies the SRP6 polymorphism at nucleotide position 18293 of SEQ ID NO:1. This specific polymorpism involves the substitution of an A to a G.
[0097] The SRP7 polymorphism was identified using the SRP7 forward and reverse primer pair (SEQ ID NOs:23 and 24). The amplicon generated using this primer pair is disclosed in SEQ ID NO:25. This sequence identifies the SRP7 polymorphism at nucleotide position 58083 of SEQ ID NO:1. This specific polymorpism involves the substitution of a T to a C.
[0098] The SRP8 polymorphism was identified using the SRP8 forward and reverse primer pair (SEQ ID NOs:26 and 27). The amplicon generated using this primer pair is disclosed in SEQ ID NO:28. This sequence identifies the SRP8 polymorphism at nucleotide position 74235 of SEQ ID NO:1. This specific polymorpism involves the substitution of an A to a G.
[0099] The SRP9 polymorphism was identified using the SRP9 forward and reverse primer pair (SEQ ID NOs:29 and 30). The amplicon generated using this primer pair is disclosed in SEQ ID NO:31. This sequence identifies the SRP9 polymorphism at nucleotide position 91068 of SEQ ID NO:1. This specific polymorpism involves the substitution of an A to a G.
Example 2
Assoclation of Polymorphisms in the SOST Gene Region with Bone Mineral Density in Elderly Subjects
[0100] Osteoporosis has a strong genetic component but the genes involved are poorly defined. The association between the gene encoding sclerostin (SOST) and bone mineral density (BMD) was examined in order to ascertain whether SOST can be considered an osteoporosis candidate gene. Sclerostin is an important regulator of bone density, and mutations in SOST result in sclerosteosis (see, e.g., NCBI Online Mendelian Inheritance in Man database of human genes and genetic disorders, [online] www.ncbi.nlm.nih.gov/omim, MIM 269500; 17q12-q21), a rare recessive sclerosing bone dysplasia. As described in Example 1, >90 kb of the SOST gene region in 90 ethnically diverse individuals was sequenced, and a set of 8 polymorphisms thus found was used to genotype 1927 men and women (55-80 years) from a large population-based prospective cohort study of elderly Dutch Caucasians. Subjects were participants of the Rotterdam Study, a population based cohort study of 7983 subjects aged 55 years and over and who live in the Ommoort district of Rotterdam, The Netherlands. The study was designed to document the occurrence of diseases in the elderly in relation to several potential determinants (Hofman et al., 1991 Eur. J. Epidemiol. 7:403). Genotype effects on BMD and on risk of vertebral and non-vertebral fractures (n=270) were analyzed during 7 years of follow-up.
[0101] Height and weight were measured at the initial examination, with the subject in a standing position with indoor clothing without shoes. BMD (in grams per square centimeter) was determined by dual-energy x-ray absorptiometry (DPX-L densitometer, Lunar, Madison, Wis.) at the femoral neck (FN) and lumbar spine (LS) (vertebrae L2, L3, L4), as described by Burger et al., 1994 Bone Miner. 25:1-13. Dietary intake of calcium (in milligrams per day) during the preceding year was assessed by a food frequency questionnaire and adjusted for energy intake. Age at menopause and current use of cigarettes were assessed by a questionnaire.
[0102] Non-vertebral fractures, including hip, wrist and other fractures were recorded by general practitioners (GPs), who covered 80% of the population. Research physicians confirmed follow-up information by checking GPs' patient records and collected the data for the remaining 20% of the population. For 600 women and 519 men, lateral radiographs of the spine from the fourth thoracic to the fifth lumbar vertebra were measured at follow-up and examined for the presence of prevalent vertebral fractures by morphometric analysis, as described by Burger et al., 1997 J. Bone Miner. Res. 12:152.
[0103] Subjects were grouped according to genotype for each polymorphism separately. Allele frequencies and Hardy-Weinberg equilibrium (HWE) were analyzed with a chi-square test. BMD and other relevant clinical variables of the three genotype groups were compared according to an allele dose effect. Allele dose was defined as the number of copies of a certain allele in the genotype. In case of a consistent trend reflected as an allele-dose effect, linear regression analysis was performed to quantify the association. In case of a dominant or a recessive effect of the test allele, analysis of (co)variance AN(C)OVA was performed to test for differences between two genotype groups. For dominant alleles test-allele carriers were compared to non-carriers, while for recessive effects homozygous subjects for the test allele were compared to heterozygous carriers combined with non-carriers. Multiple linear regression was used to adjust bone-density values for possible confounding factors such as age and anthropometric variables. To estimate the risk of non-vertebral and vertebral fractures, odds ratios (with 95 percent confidence intervals) were calculated by multivariate logistic regression analysis.
[0104] No SOST gene coding polymorphisms were found, but 3 variants within 8 kb upstream of the coding sequence were identified, in addition to 3 variants within a far downstream 52 kb interval recently found to be deleted in van Buchem disease, a monogenic bone disorder very similar to sclerosteosis. A 3 bp GGA-insertion in the SCL promoter region (SRP3; allele frequency 39%) was shown to be associated with decreased BMD in women at the femoral neck (p=0.05) and at the lumbar spine (p=0.01) with evidence for an allele-dose effect. Genotype differences were found to strongly increase with age (FIG. 1). In addition, a G-substitution in the van Buchem deletion region (SRP9; allele frequency 41%) was found to be associated with increased BMD in men at femoral neck (p=0.006) and at lumbar spine (p=0.01) with evidence for an allele-dose effect. In both cases differences between extreme genotypes amounted to 0.2 SD and no genotype effects on fracture risk were observed. Variants in the SOST gene region were thus shown to be associated with BMD differences and were found to be modified as a function of gender (SRP3 and 9) and of age (SRP3).
[0105] From the foregoing it will be appreciated that, although specific embodiments of the invention have been described herein for purposes of illustration, various modifications may be made without deviating from the spirit and scope of the invention. Accordingly, the invention is not limited except as by the appended claims.




0











SEQUENCE LISTING





<160> NUMBER OF SEQ ID NOS: 34



<210> SEQ ID NO 1

<211> LENGTH: 130320

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 100722, 100754, 102080, 117731, 124408, 124532, 124585,

124955, 124956, 124963, 124964, 124965, 124967

<223> OTHER INFORMATION: n = A,T,C or G



<400> SEQUENCE: 1



cacccccatc cccagctccc agggcctctg ccacgcgggc ttcttttttt ttttgagaca 60



gagtctcgct ctgtcaccca ggctggagca caatctcagc acaatctcac ctcaccgcaa 120



cctctgcctc ctgggttcaa gcaattctct ggcctcagcc tcctgagtag ctgggattat 180



aggctcgcgc caccacaccc agctattttt ttgtatcttt agtaaagacg ggatttcact 240



atgttggcca gtctggtctc gaactcctga ccttgtgatc cagttgcctt ggcctcccaa 300



agtgctggga ttacaggcgt gagccactgt gcccagcccc ttgcaggctt ctgacagcac 360



agatggtttt gcccgctttc ctactctgtg ggctcatcca cctcatatgt gtgtgctgcc 420



tccgtgttgc ttctgctaag tggcagtctg gtcattcttt gtatttgtcc tttctactgt 480



ggatgggcct ttgggggttt ctaactgtgg gccatgatgt gcagtgttgc ctgtgaacat 540



tctggcccat gttcgtgaat gtgaatgcgt atctctattg gacctgggcc tgggagtggg 600



attgctgggc cagaggggat gcacgtgttc agcttgagga gataccgccg tgccgcacag 660



ctttccaaag tggttgtgcc aattcacgcc tcacctcccc cagccacgca gaagagttcc 720



agttgcccca tatcttcacc agcactttgg gttttccatc cttttcattt tagccattct 780



gacaggcaca cagtggcgtg acattgtgct tttaagtggc acttcacgga agagtcttga 840



ccaacgccat ggtgtgatgg gacgccccca gctcaccacg tctcccctgt ttcttacagg 900



ccgggtgctc gtccactgcc gggaaggtta tagccgctcc ccaacgctag ttatcgccta 960



cctcatgatg cggcagaaga tggacgtcaa gtctgccctg agcatcgtga ggcagaaccg 1020



tgagatcggc cccaacgatg gcttcctggc ccagctctgc cagctcaatg acagactagc 1080



caaggagggg aagttgaaac cctagggcac ccccaccgcc tctgctcgag aggtccgtgg 1140



gggaggccgt gggcaaaggt gtcccgagct gccatgttta ggaaacacac tgtaccctgc 1200



tcccagcatc acaaggcact tgtctacaag tgtgtcccaa cacagtcctg ggccactttc 1260



cccaccctgg ggagcacata aagaagcttg ccaagggggg cgtccttgct ccccagttgt 1320



cctgtttctg taacttatga tgtcttttcc ctgagatggg ggctcagagg gggaaggcct 1380



gtggcctgca tgcttcccga tggcccacgg caggaggtgt gtggaagtgt aaggcctaag 1440



atgctcacag aggtccctca tgacctccct tccccaactc ccgaatcctc tcttgagtgt 1500



ggacctcaac accttgagcc ctagtaaagg aactatgcaa atgcaggcca ctctccccac 1560



cacgtctgtg ccccgcactg tccccacagc cttccacacc ctgtgcatag gcagccctct 1620



cacgtcttga ggtccgaagc tggggtgggg gtgtccgtca gttattagtg gatggagatt 1680



cccacagcaa ggctgcattt gaatgatttc cttaggatga atggtcccta cacaaagagg 1740



ccttgtgggc aaacctggag aaccctccta aatccataga gttttcaaaa tgtgaatctt 1800



tggaagcctt gagttcagaa tctgctgctc tggaatattt cccttcgatc ttatctcagt 1860



cacttcgttt ttgagaagag tgatgccttg ggcatgcttt tttttttttc ttttttagaa 1920



aacagggagt tgaagtccaa cctatttaaa aaccccacca tttggagaat tacaagggtt 1980



ttgtcctgaa ttgtagtgtt ggcaagccca agccactcgt gctaactgct ttttgtctcg 2040



gttgctattc caagaacaga aggaggaagt tggccaatta cagcgtgtgt gcatggatgt 2100



gtgtgggggg cgtgcctctc agaaacgcgg ccagaagaca agcagggaag tgaaaggtcc 2160



caggcacaca ccctgcccat tgcaggtggc tcttacagct ctctggtgcc agcacgggat 2220



ccctgaagtg actcagccag gcagacatga gacatggcgg agtgtccaaa tggatccttt 2280



attggtggta gagcaaaaaa acccaaacac gataaacctt tcaaaagact ttctaaggat 2340



gatattggaa tgcaccagcc ctcacatgtg tatgcacatt tgccagaata taagagtttt 2400



gttttaaata cagtcttgtt aggattttac gttattgtta ttatggaaag tgattgtgat 2460



gctatttatc ttcagggtca ctctgggcaa agagaaggtc ctcagccatg cccccagcac 2520



cttgcacata ggtgtctgat aaaagtttaa gaaattaaac actttttgag caccaaatat 2580



atatagggca ttgttctggt gggtgtgtca cgctcccaga agactgaatt tatggtagga 2640



tcactcgcaa ggccttgtga aggagtctta cctaaaacaa aagaaatatc agggactttt 2700



gttgactatt tacaactcag ttttacattt aaattcaggc agtgttaata tgccaaggta 2760



gggaatgtgc ctttttcaga gttggccagg agctcctggc tgggacacgg agaggcaggt 2820



gtggcgtaag gcctcactcc cggctgtgaa ggtctctgat cacacagaag cagccctgcc 2880



cagcctggtc atttgctgtc cgcttttctc tgtgaccaca gcagccctga acaaccagta 2940



tgtgtcttct tctccagata gtgaaaaagg tgtccagata aacccaccta agtgaaatgg 3000



ccatcctcta aactgggtac ctcactgcac agcttctagg tagccttcca acttaatcta 3060



acttgagcct cacagtaacc ctgtaaagtt agtagagctt gttcttgtat tgtgaccttt 3120



tttaaaaaaa aggaactgag gttcagaatg attaagggcc tggcccccag ggttgtccag 3180



ctccataagg tggagctggg caagattttg ggtttgctgc tccctgaagc tggattcttt 3240



catacgatac tctttctcaa gaagggggct ccctgggatc tccaggtgta ctgcacttac 3300



cctcaatcca gccccggaga agcaagtgaa aagggtgggt ccctcatagg ctagaatgtg 3360



cagctctttc tccaggtggg atgtagcacc ccaaagtaga gctttctgct ctgctcctgg 3420



aaaaggctag ggagctgggg ctggggctcc cctcccatga ccaggcagtg gtcaccccat 3480



gggacaggca cagctactta cgcgaacaca gcaggttggt gtggctggct aactaggacc 3540



tctcgaaagt ctctgtgggg gcatgaggga gaaaaggcca ttgggagaat tactgccttt 3600



actttgggac tacttttatg ctgataactt gggatttctt gatagtcctt cacccctgaa 3660



accccgtatt tacttaacaa gatttagctc ttagttcttc aagtaaaatt aaagtctctt 3720



gtgtaagagc caacacatgc ccagctgcgg atgggagctg ttcctggaca gccttctact 3780



gcctgggaag tgatggaaca ggaactcagg gtgcccttac cccctcccca gacctgttcc 3840



ctttctttga ctgacagagc accatccagg caaaattaga gcgccaaatg gttttcttct 3900



caatcttaaa gcagtatacc tttccacagg ctcgtctgtg tccctgccac tctgagttat 3960



ccagaaacca ccacctacaa atgaggggac tcatctagaa gacctctaag gtcccctttt 4020



ggctctgagg ggtctctaat aatccccact tggaattcag caccgcaagg aaattatggg 4080



tatgtgagcc ataatatgat ggccagcagg tggcgctgcc ttccacccat ggtgatggat 4140



ggtttggaaa gggaatgttg gtgccttttg tgccacaagt taagatgcta ctgttttaaa 4200



ggaaaaaaaa aaaaaaaagt actgatcttc aatatgaaga catgagcttt tctcgcagga 4260



aattttcttt ttcacagaac tggtgtcagg aatcactgaa gggctaaccg tgatagtcct 4320



tgcaagtaag tcaaggtttt atcctgattg gaaatagaag acatttccgg ttgagagaac 4380



agattcgttg gaagcttaac ttttgttgcc tcttaacgcc accaaatttt agggtaattt 4440



gattatgaaa gagtgaattt ttctggacag aaaagggaga gctaccaaat tgtttttttc 4500



tttttaaaag gaagtttaat gtccgttgta tcacaaatca gtgttaaaac accagaactt 4560



tagccaaaat aaatgtctta cattacaaag gtattgtttt tttgtccttc ttatcacagt 4620



tggtattctt ttacgttttt atgcttagct ttttttgttt gggcttagct tttatatttg 4680



cgatttctaa ctttttaaaa ataatcatct aaaacatagc cgttctgagc tagttatagg 4740



ttccatgatg gcactgttta tgcagtagat attgatgaac acctttccag taccagaaat 4800



gttctggtag gaatattctt aggtagaatg gccataatgg tcctgaatga aggaggtaag 4860



gtttgtgctt ctaagaaagc aggggactag ggtgttcatc tcaaggtagc ctcacgtgat 4920



gactgggtga cattttgaga tttgagtgat cctgcaaatg aacagtccct aaacatatcc 4980



ccttccccca gatgccttaa attccactat tggtgctatg ttcctttgaa taaaaaacct 5040



tagagaaagt aggtgccttt tcctcccaga cagaagtctg ggcagagaaa gcctctcgag 5100



gttcccattc cctctatcac atgaagcaat tggactcgct tcctatttgt caagactctg 5160



acaatgtaat ctttatggtt ctacacaaaa tcttaaggca gagcactaaa atataaaaca 5220



ggtaaaagtt tttaagtata atttttaaaa aatttttcat taaaaataat actatatgta 5280



catagtaata cacttaaaca atgcaaaagg cttatacgga aaagtgagtc acttgctcct 5340



tcaatctatc tccccataag cgtcatatcc ttaaaggaaa atgtcaagca tatataagca 5400



cacatatgtg catacgtgtg tatatacaga gatatctctg ctttgttgtt tgttttgctt 5460



agcttatatt atggttattg tttttattgc tctaccccct tcatcttaac agctacatag 5520



cattccattg tgtatggatg tgtaaataaa gacaaggtga tttggacatc cctcaatgca 5580



gggtactgcc taaaagcaga agtttgccct cctaatccag atatttcctt tttaccacct 5640



acaagtggga gcaaaatctg ttttaaaatg cagccaataa ggagaatcct cagtttccat 5700



taattagaga taggggcctc ctccagaacc aagtagagaa tgaaaccgga tgacctttga 5760



gagtccttcc agatcaaaga ttctatgatc ccaaggagtc aaaggagcat aatatacttt 5820



ccaaatttgg cctgtcattc aaagtctggt ccaaatgcca catcttacca taaggatccc 5880



agatcctccc caggggaaag agattgttct ctcctttgaa ggcccataag aaaattgtcc 5940



ttttgaaaaa atgcatctgg tgaggatgtg gaacaacagg aactctttgt ttcagtgggg 6000



aatgcaaaat ggtacagcca ctttggagga cagtttgcag tttagtttct tgcaaaacta 6060



cacatacttt tattgcacaa tccagcagtc atgctccttg gtatttattc aaatgatttg 6120



aaaacttaac gttcgtataa aaacctgcac acagctgggc atggtggctc atgcctgtaa 6180



tcccagcact ttgggaggct gaggtgggca gatcacttga ggttaggagt ttgagaccat 6240



actggccaac atggggaaac cccttctcta ctaaaaatac aaaaattagc caggtgtggt 6300



ggtgctcacc tgtaatccca cctactcggg aggctgagcc aggagaatca cttgaaccca 6360



ggaggcggag gttgcagtga gctgagatca cggcactgca ccccagcctg ggagacagag 6420



taagactccg tcttaagaca aaacaaaaca aaaaacctgt acaaaatgtt tataccacct 6480



ctattaataa ttgccagagc ttgaaagcaa ccaagatgtc cttcagtaga tgacagtagg 6540



tgactagata aaccgtgata catcaagacg atggagtatt actcagtgct aaaaaaaaaa 6600



ataagctgtt catgccatga aaagacatgg aggaacccca aatgaatatt actaactgaa 6660



agaagccaat ctgaaaagac tatgtatggg tatattccaa ctctatatga catcctggaa 6720



aaggcaaaaa taaaggtaca gtaaaaagat cagtggttgc caggggttgg ggaaagtcgg 6780



ggagggatga ataggcagag cagatagttt ttttggacaa tgaaaatact gcccatctgt 6840



atgatactat aatggtagat gtatgtcatt atacatttgt ccaaagccat aggatgtaca 6900



acactagtgc tgtgatgtaa accatggact tcaggtgata atgatgtgtc atgtaggctc 6960



atcaatcata gcaaatgcac cactctggtg gcgggatgtt gataacgggg gcagctgtac 7020



atgtgtgggc acaggacata aatgagaaat ctctgtacca tccactcagt tttgctgtga 7080



acctaaaagt gctccagaaa aaaaataaag ttttttttag aaaaaagcat ctgaaccttt 7140



ttttcagtgg cattgatcac cttccatctg gtagtggagt tgtttggatg cggaaattat 7200



ttcttccatg gtatgcgagc tcctggagag ggagtgcgtg tcccccttgc tttattaaac 7260



gtttggcgag tgaacatcag aagaagcaac tcgacagaaa caaaagctgg taaataatca 7320



catggaaaag cagcttttct ggaaattaag tttcaactgt taaattcaat gtttaaaaaa 7380



atcggctggg tgcggtggct cccgcctgca atcccagcac tttatgggat tgtgggaaca 7440



cctgatgtca ggagttcaag accagcctgg ccgacatggc gaaaccccat ctctacaaaa 7500



caaacaaaaa aaaatgcaaa aattagctgg gtgtggtggc gggagtctgt agtcctagct 7560



actcgggagg ctgaggcagg agaactgctt gaacccagga ggtggaggtt atatgagcca 7620



agatcacacc actgcactcc cgcctgggtg acagagcgag actctgtctc aaaaaaaaaa 7680



aaaaaaatca acatcccaaa cccagtgttg acagtcttat ttatgggttg aactgcattc 7740



ctcccaaatg catatattga agtcctaagt cacagtacct gagaatgtga ccttatttgg 7800



aaatagggct attacagatg taactcgtta agatgaggtc attaggctgg gcctaatcta 7860



atatgcctga cctccttaga aaaaagggaa aattcgaaca cagagagaac accatgtgaa 7920



gatgaaggca gggattgggg gtgacacttc tgcaagccag tgaatgccac agcttgtcag 7980



cagccagcag aaggcaggta aaaggccttc ctcactgtcc tcgaaggaac caactctgcc 8040



aatgtcttga acttgcactc ctaacctcca gctctgtgag acgacttctg ttgtttatgc 8100



cacccaattt gtggtactta gttacggcag cctcatcaaa gtaccaccta tgggagcctc 8160



tattttgcag gtgagggcgg ggactgggct gagttttctg gaaaacagcc ctgcaatacc 8220



ctcatcagac caccaaactc ttcacactcc ctcagacaca gcattcactt ccagaaataa 8280



ctctaaagtt ttgttttgtt tttttaaact ttgtggaata ctactcagcc aaaaaaaaaa 8340



aaaaagaaaa gaaaaaggaa catgttactg atatgtacaa cttggataat ggaaataatg 8400



ctgagtgaaa aaaaaatccc caaaggctac atactaattg attccattta tataaccttt 8460



tttttttttt tttgagacag tctcactctg tcacccaggc tggagcacag tggcgcgatc 8520



tcagctcact gcaacttccg cctcctgagt tcaagcgatt ctcttgcctt agcttcccaa 8580



gtagctggga ttacaggtgc gtgccaccat gcccagctaa tttttgtatt tttagtagag 8640



acagggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcaag tgatctgcct 8700



gccttggctt cccaaagtgc tgggattaca tgagtgagcc accgcacctg gtcgcattta 8760



tgtaacaatt ttgaagtgaa aaaaaaaatg acagaaatgg agattagatg agtagttgcc 8820



aggggttagt tgtgggaggg agggaaaagg agggaaggag gtgggcaaca ggagaaagac 8880



ttgtggtcac agagctgtgc tttatcttga ctgtggtgga tccccaaatt tacccgtgac 8940



aagattgcat agaactaagt atacacacac gtgaatgcgt gtgcacgcac acagtagagg 9000



ttaagccacg ggagatgtgg gtaagattgg taaattgtgt caatatcaat atcctagttg 9060



tgatattgtc ctatagtttc gcaaggtgtt attgttgtgg gaaactggat aaaggataca 9120



cggagtctgc attttctttt ttttattttt attttttgag acggggtctc actctgtcaa 9180



ccaggctgga gtgcagtggc ccaagtatgg ctcactgcag cctcgacctc aacctcaagt 9240



gaacctccca cctcagcctc ccaagtagct aagaccacag gcgtgcgacc ccatgcccag 9300



ctaattttta aattttttgt agagactagg cctcaccatg ttgcccaggc ttttatttct 9360



tataagtata tttaaattta taattatatc cacattttaa aattttaatt taaaaaatta 9420



ctctgaggcc gggcattgtg gctcatgcct ctaatcccca gcaccttggg aggccgagtt 9480



gggcagatca cccgaggtca gaagttcgag accagcctga gtaacatgga gaaacccccg 9540



tctctactaa aaatacaaaa ttggccgggc gtggtggtgc attcctgtaa tcccagctac 9600



tcgggaggct gaggcaggag aattgcttga acccaggagg tggaggttgc agtgagccaa 9660



gattgtgcca ctgcactgca gcctgggcca cagagagaat ctgccaaaaa aagaaaaaaa 9720



aaaaaatttc agccgtacaa ggatgttcat agcaaccctg ctggaaatag gaaaaaaaat 9780



tggaaataac ctaaactact cacaatagga atcagctaaa accctggggg tttaattcca 9840



gggaatactg tgaacaatga caagtttgtg gactgagtaa aaataaacag ctgtcaatga 9900



cttaacatta aatgaaacag cagaagatgt cacagcaggt tctcgctgag ccattcagag 9960



gggtgtggat catttagagg ttcaagtcca ctggattctt ctttttcctt ttaatattac 10020



ttcacttcca aataaggaaa ggaaaggaaa ggaaatcacg tccagtcctg agacttgcca 10080



tcctgcagtc acccctcctt ttgtctccag caggtggcag acgcgttcca gggatgaatc 10140



ccactgcctc tgtttaatgc agacggtcca gccgctccca acagcaggtg gggctataag 10200



catccatcct acctgctcaa ggaacccagg catcagaact gctctctccc aagtccattg 10260



caagaaggca gtcgtctggt catgagaggg ttaacagtcc acattccaga gcaagggaaa 10320



aggaggctgg agggtcatag acaaggggag gtggtgcgga gggccagctt ctcacaacac 10380



taccggctct gctgggagag atagatcacc cccaacaatg gccacagctg ttttcatctg 10440



ccctgaagga aactgactta ggaagcaggt atcagagagg gcccttcctg agggggcttc 10500



tgtctggctt gtaaaactgt cagagcagct gcattcatgt gtcggatgat ggatgatgga 10560



aaggacagtc ggctgcagat ggacacagcg acttgcaagt tgaggcaggt ggcaaaggac 10620



ttgcagaggc tctgcaggtg gggcatgctg attcattgcc cagttaaaat accagaggat 10680



ctgggcagcc tcttcacagg agctgcttgt cctcaaacaa tctgtcttca atgaaagatt 10740



cctctggcct tcctttctct tcttgcacct caggtgtgaa tccttctccc ccacgcctct 10800



acctgcgccc ccgccccccg ccccggccct gtgtggctca ttatatgcag ggccaaggca 10860



gcattttctc ttagcttctt tgtgaccagt tggtcctggg atggcttcat ggaacacatc 10920



ctgtggtgtg caccaatgaa gctttccata caggactcaa aactgttttt gaaaaatgta 10980



accagctgga agacaagaaa ataaaatgtc agcactaaaa acgctggctg tggcttttgc 11040



taaggaaagg aatttggtgt tgtcttctca cacacacaga ctggttgggg aaatgactgt 11100



cttcagcaca tcaccctgcg agccacagtg agtgccctgg ctcagaagtg cctgtcacag 11160



tgcacaggat ccctgaggag catgagctgg gatttcctct gtgctgtcca tcacaggagc 11220



ctgagtgacc agcgcatcct cgatttgtaa ccagaatcct gccctctctc ccaagcgggc 11280



acccttgctc tgaccctcta gttctctctc ttgccttcca gagaatacca agagaggctt 11340



tcttggttag gacaatgaat gctgagactt gtggagttgg gaccaatggg atttctttaa 11400



aagcatcttt ttgcctctgg ctgggtctat gggggtcaaa cagaaacacc ttgggccatt 11460



tgttggtggg gtgacaaatg aacttggcct gagaaatgga ataggccggg ctcagccccg 11520



cgaagcactc agaactgcac attttctttg ttgagcgggt ccacagtttg ttttgagaat 11580



gcccgagggc ccagggagac agacaattaa aagccggagc tcattttgat atctgaaaac 11640



cacagccgcc agcacgtggg aggtgccgga gagcaggctt gggccttgcc tcacacgccc 11700



cctctctctg ggtcacctgg gagtgccagc agcaatttgg aagtttgctg agctagagga 11760



gaagtctttg gggagggttt gctctgagca cacccctttc cctccctccg gggctgaggg 11820



aaacatggga ccagccctgc cccagcctgt cctcattggc tggcatgaag cagagagggg 11880



ctttaaaaag gcgaccgtgt ctcggctgga gaccagagcc tgtgctactg gaaggtggcg 11940



tgccctcctc tggctggtac catgcagctc ccactggccc tgtgtctcgt ctgcctgctg 12000



gtacacacag ccttccgtgt agtggagggc caggggtggc aggcgttcaa gaatgatgcc 12060



acggaaatca tccccgagct cggagagtac cccgagcctc caccggagct ggagaacaac 12120



aagaccatga accgggcgga gaacggaggg cggcctcccc accacccctt tgagaccaaa 12180



ggtatggggt ggaggagaga attcttagta aaagatcctg gggaggtttt agaaacttct 12240



ctttgggagg cttggaagac tggggtagac ccagtgaaga ttgctggcct ctgccagcac 12300



tggtcgagga acagtcttgc ctggaggtgg gggaagaatg gctcgctggt gcagccttca 12360



aattcaggtg cagaggcatg aggcaacaga cgctggtgag agcccagggc agggaggacg 12420



ctggggtggt gagggtatgg catcagggca tcagaacagg ctcaggggct cagaaaagaa 12480



aaggtttcaa agaatctcct cctgggaata taggagccac gtccagctgc tggtaccact 12540



gggaagggaa caaggtaagg gagcctccca tccacagaac agcacctgtg gggcaccgga 12600



cactctatgc tggtggtggc tgtccccacc acacagaccc acatcatgga atccccagga 12660



ggtgaacccc cagctcgaag gggaagaaac aggttccagg cactcagtaa cttggtagtg 12720



agaagagctg aggtgtgaac ctggtttgat ccaactgcaa gatagccctg gtgtgtgggg 12780



gggtgtgggg gacagatctc cacaaagcag tggggaggaa ggccagagag gcacccctgc 12840



agtgtgcatt gcccatggcc tgcccaggga gctggcactt gaaggaatgg gagttttcgg 12900



cacagtttta gcccctgaca tgggtgcagc tgagtccagg ccctggaggg gagagcagca 12960



tcctctgtgc aggagtaggg acatctgtcc tcagcagcca ccccagtccc aaccttgcct 13020



cattccaggg gagggagaag gaagaggaac cctgggttcc tggtcaggcc tgcacagaga 13080



agcccaggtg acagtgtgca tctggctcta taattggcag gaatcctgag gccatggggg 13140



cgtctgaaat gacacttcag actaagagct tccctgtcct ctggccatta tccaggtggc 13200



agagaagtcc actgcccagg ctcctggacc ccagccctcc ccgcctcaca acctgttggg 13260



actatggggt gctaaaaagg gcaactgcat gggaggccag ccaggaccct ccgtcttcaa 13320



aatggaggac aagggcgcct ccccccacag ctccccttct aggcaaggtc agctgggctc 13380



cagcgactgc ctgaagggct gtaaggaacc caaacacaaa atgtccacct tgctggactc 13440



ccacgagagg ccacagcccc tgaggaagcc acatgctcaa aacaaagtca tgatctgcag 13500



aggaagtgcc tggcctaggg gcgctattct cgaaaagccg caaaatgccc ccttccctgg 13560



gcaaatgccc ccctgaccac acacacattc cagccctgca gaggtgagga tgcaaaccag 13620



cccacagacc agaaagcagc cccagacgat ggcagtggcc acatctcccc tgctgtgctt 13680



gctcttcaga gtgggggtgg ggggtggcct tctctgtccc ctctctggtt tggtcttaag 13740



actatttttc attctttctt gtcacattgg aactatcccc atgaaacctt tgggggtgga 13800



ctggtactca cacgacgacc agctatttaa aaagctccca cccatctaag tccaccatag 13860



gagacatggt caaggtgtgt gcaggggatc aggccaggcc tcggagccca atctctgcct 13920



gcccagggag tatcaccatg aggcgcccat tcagataaca cagaacaaga aatgtgccca 13980



gcagagagcc aggtcaatgt ttgtggcagc tgaacctgta ggttttgggt cagagctcag 14040



ggcccctatg gtaggaaagt aacgacagta aaaagcagcc ctcagctcca tcccccagcc 14100



cagcctccca tggatgctcg aacgcagagc ctccactctt gccggagcca aaaggtgctg 14160



ggaccccagg gaagtggagt ccggagatgc agcccagcct tttgggcaag ttcttttctc 14220



tggctgggcc tcagtattct cattgataat gagggggttg gacacactgc ctttgattcc 14280



tttcaagtct aatgaattcc tgtcctgatc acctcccctt cagtccctcg cctccacagc 14340



agctgccctg atttattacc ttcaattaac ctctactcct ttctccatcc cctgtccacc 14400



cctcccaagt ggctggaaaa ggaatttggg agaagccaga gccaggcaga aggtgtgctg 14460



agtacttacc ctgcccaggc cagggaccct gcggcacaag tgtggcttaa atcataagaa 14520



gaccccagaa gagaaatgat aataataata cataacagcc gacgctttca gctatatgtg 14580



ccaaatggta ttttctgcat tgcgtgtgta atggattaac tcgcaatgct tggggcggcc 14640



cattttgcag acaggaagaa gagagaggtt aaggaacttg cccaagatga cacctgcagt 14700



gagcgatgga gccctggtgt ttgaacccca gcagtcattt ggctccgagg ggacagggtg 14760



cgcaggagag ctttccacca gctctagagc atctgggacc ttcctgcaat agatgttcag 14820



gggcaaaagc ctctggagac aggcttggca aaagcagggc tggggtggag agagacgggc 14880



cggtccaggg caggggtggc caggcgggcg gccaccctca cgcgcgcctc tctccacaga 14940



cgtgtccgag tacagctgcc gcgagctgca cttcacccgc tacgtgaccg atgggccgtg 15000



ccgcagcgcc aagccggtca ccgagctggt gtgctccggc cagtgcggcc cggcgcgcct 15060



gctgcccaac gccatcggcc gcggcaagtg gtggcgacct agtgggcccg acttccgctg 15120



catccccgac cgctaccgcg cgcagcgcgt gcagctgctg tgtcccggtg gtgaggcgcc 15180



gcgcgcgcgc aaggtgcgcc tggtggcctc gtgcaagtgc aagcgcctca cccgcttcca 15240



caaccagtcg gagctcaagg acttcgggac cgaggccgct cggccgcaga agggccggaa 15300



gccgcggccc cgcgcccgga gcgccaaagc caaccaggcc gagctggaga acgcctacta 15360



gagcccgccc gcgcccctcc ccaccggcgg gcgccccggc cctgaacccg cgccccacat 15420



ttctgtcctc tgcgcgtggt ttgattgttt atatttcatt gtaaatgcct gcaacccagg 15480



gcagggggct gagaccttcc aggccctgag gaatcccggg cgccggcaag gcccccctca 15540



gcccgccagc tgaggggtcc cacggggcag gggagggaat tgagagtcac agacactgag 15600



ccacgcagcc ccgcctctgg ggccgcctac ctttgctggt cccacttcag aggaggcaga 15660



aatggaagca ttttcaccgc cctggggttt taagggagcg gtgtgggagt gggaaagtcc 15720



agggactggt taagaaagtt ggataagatt cccccttgca cctcgctgcc catcagaaag 15780



cctgaggcgt gcccagagca caagactggg ggcaactgta gatgtggttt ctagtcctgg 15840



ctctgccact aacttgctgt gtaaccttga actacacaat tctccttcgg gacctcaatt 15900



tccactttgt aaaatgaggg tggaggtggg aataggatct cgaggagact attggcatat 15960



gattccaagg actccagtgc cttttgaatg ggcagaggtg agagagagag agagaaagag 16020



agagaatgaa tgcagttgca ttgattcagt gccaaggtca cttccagaat tcagagttgt 16080



gatgctctct tctgacagcc aaagatgaaa aacaaacaga aaaaaaaaag taaagagtct 16140



atttatggct gacatattta cggctgacaa actcctggaa gaagctatgc tgcttcccag 16200



cctggcttcc ccggatgttt ggctacctcc acccctccat ctcaaagaaa taacatcatc 16260



cattggggta gaaaaggaga gggtccgagg gtggtgggag ggatagaaat cacatccgcc 16320



ccaacttccc aaagagcagc atccctcccc cgacccatag ccatgtttta aagtcacctt 16380



ccgaagagaa gtgaaaggtt caaggacact ggccttgcag gcccgaggga gcagccatca 16440



caaactcaca gaccagcaca tcccttttga gacaccgcct tctgcccacc actcacggac 16500



acatttctgc ctagaaaaca gcttcttact gctcttacat gtgatggcat atcttacact 16560



aaaagaatat tattggggga aaaactacaa gtgctgtaca tatgctgaga aactgcagag 16620



cataatagct gccacccaaa aatctttttg aaaatcattt ccagacaacc tcttactttc 16680



tgtgtagttt ttaattgtta aaaaaaaaaa gttttaaaca gaagcacatg acatatgaaa 16740



gcctgcagga ctggtcgttt ttttggcaat tcttccacgt gggacttgtc cacaagaatg 16800



aaagtagtgg tttttaaaga gttaagttac atatttattt tctcacttaa gttatttatg 16860



caaaagtttt tcttgtagag aatgacaatg ttaatattgc tttatgaatt aacagtctgt 16920



tcttccagag tccagagaca ttgttaataa agacaatgaa tcatgaccga aaggatgtgg 16980



tctcattttg tcaaccacac atgacgtcat ttctgtcaaa gttgacaccc ttctcttggt 17040



cactagagct ccaaccttgg acacaccttt gactgctctc tggtggccct tgtggcaatt 17100



atgtcttcct ttgaaaagtc atgtttatcc cttcctttcc aaacccagac cgcatttctt 17160



cacccagggc atggtaataa cctcagcctt gtatcctttt agcagcctcc cctccatgct 17220



ggcttccaaa atgctgttct cattgtatca ctcccctgct caaaagcctt ccatagctcc 17280



cccttgccca ggatcaagtg cagtttccct atctgacatg ggaggccttc tctgcttgac 17340



tcccacctcc cactccacca agcttcctac tgactccaaa tggtcatgca gatccctgct 17400



tccttagttt gccatccaca cttagcaccc ccaataacta atcctctttc tttaggattc 17460



acattacttg tcatctcttc ccctaacctt ccagagatgt tccaatctcc catgatccct 17520



ctctcctctg aggttccagc cccttttgtc tacaccacta ctttggttcc taattctgtt 17580



ttccatttga cagtcattca tggaggacca gcctggccaa gtcctgctta gtactggcat 17640



agacaacaca aagccaagta caattcagga ccagctcaca ggaaacttca tcttcttcga 17700



agtgtggatt tgatgcctcc tgggtagaaa tgtaggatct tcaaaagtgg gccagcctcc 17760



tgcacttctc tcaaagtctc gcctccccaa ggtgtcttaa tagtgctgga tgctagctga 17820



gttagcatct tcagatgaag agtaacccta aagttactct tcagttgccc taaggtggga 17880



tggtcaactg gaaagcttta aattaagtcc agcctacctt gggggaaccc acccccacaa 17940



agaaagctga ggtccctcct gatgacttgt cagtttaact accaataacc cacttgaatt 18000



aatcatcatc atcaagtctt tgataggtgt gagtgggtat cagtggccgg tcccttcctg 18060



gggctccagc ccccgaggag gcctcagtga gcccctgcag aaaatccatg catcatgagt 18120



gtctcagggc ccagaatatg agagcaggta ggaaacagag acatcttcca tccctgagag 18180



gcagtgcggt ccagtgggtg gggacacggg ctctgggtca ggtttgtgtt gtttgtttgt 18240



ttgttttgag acagagtctc gctctattgc ccaggctgga gtgcagtgtc acaatctcgg 18300



cttactgcaa cttctgcctt cccggattca agtgattctc ctgcctcagc ctccagagta 18360



gctgggatta caggtgcgtg ccaccacgcc tggctaattt ttgtattttt gatagagacg 18420



gggtttcacc atgttggcca ggctagtctc gaactcttga cctcaagtga tctgcctgcc 18480



tcggcctccc aaagtgctgg gattacaggc gtgagccacc acacccagcc ccaggttggt 18540



gtttgaatct gaggagactg aagcaccaag gggttaaatg ttttgcccac agccatactt 18600



gggctcagtt ccttgcccta cccctcactt gagctgctta gaacctggtg ggcacatggg 18660



caataaccag gtcacactgt tttgtaccaa gtgttatggg aatccaagat aggagtaatt 18720



tgctctgtgg aggggatgag ggatagtggt tagggaaagc ttcacaaagt gggtgttgct 18780



tagagatttt ccaggtggag aagggggctt ctaggcagaa ggcatagccc aagcaaagac 18840



tgcaagtgca tggctgctca tgggtagaag agaatccacc attcctcaac atgtaccgag 18900



tccttgccat gtgcaaggca acatgggggt accaggaatt ccaagcaatg tccaaaccta 18960



gggtctgctt tctgggacct gaagatacag gatggatcag cccaggctgc aatcccatta 19020



ccacgagggg gaaaaaaacc tgaaggctaa attgtaggtc gggttagagg ttatttatgg 19080



aaagttatat tctacctaca tggggtctat aagcctggcg ccaatcagaa aaggaacaaa 19140



caacagacct agctgggagg ggcagcattt tgttgtaggg ggcggggcac atgttctggg 19200



ggtacagcca gactcagggc ttgtattaat agtctgagag taagacagac agagggatag 19260



aaggaaatag gtccctttct ctctctctct ctctctctct ctcactctct ctctctctca 19320



cacacacaca cagacacaca cacacgctct gtaggggtct acttatgctc caagtacaaa 19380



tcaggccaca tttacacaag gaggtaaagg aaaagaacgt tggaggagcc acaggacccc 19440



aaaattccct gttttccttg aatcaggcag gacttacgca gctgggaggg tggagagcct 19500



gcagaagcca cctgcgagta agccaagttc agagtcacag acaccaaaag ctggtgccat 19560



gtcccacacc cgcccacctc ccacctgctc cttgacacag ccctgtgctc cacaacccgg 19620



ctcccagatc attgattata gctctggggc ctgcaccgtc cttcctgcca catccccacc 19680



ccattcttgg aacctgccct ctgtcttctc ccttgtccaa gggcaggcaa gggctcagct 19740



attgggcagc tttgaccaac agctgaggct ccttttgtgg ctggagatgc aggaggcagg 19800



ggaatattcc tcttagtcaa tgcgaccatg tgcctggttt gcccagggtg gtctcgttta 19860



cacctgtagg ccaagcgtaa ttattaacag ctcccacttc tactctaaaa aatgacccaa 19920



tctgggcagt aaattatatg gtgcccatgc tattaagagc tgcaacttgc tgggcgtggt 19980



ggctcacacc tgtaatccca gtactttggg acgtcaaggc gggtggatca cctgaggtca 20040



cgagttagag actggcctgg ccagcatggc aaaaccccat ctttactaaa aatacaaaaa 20100



ttagcaaggc atggtggcat gcacctgtaa tcccaggtac tcgggaggct gagacaggag 20160



aatggcttga acccaggagg cagaggttgc agtgagccaa gattgtgcca ctgccctcca 20220



gccctggcaa cagagcaaga cttcatctca aaagaaaaag gatactgtca atcactgcag 20280



gaagaaccca ggtaatgaat gaggagaaga gaggggctga gtcaccatag tggcagcacc 20340



gactcctgca ggaaaggcga gacactgggt catgggtact gaagggtgcc ctgaatgacg 20400



ttctgcttta gagaccgaac ctgagccctg aaagtgcatg cctgttcatg ggtgagagac 20460



taaattcatc attccttggc aggtactgaa tcctttctta cggctgccct ccaatgccca 20520



atttccctac aattgtctgg ggtgcctaag cttctgccca ccaagagggc cagagctggc 20580



agcgagcagc tgcaggtagg agagataggt acccataagg gaggtgggaa agagagatgg 20640



aaggagaggg gtgcagagca cacacctccc ctgcctgaca acttcctgag ggctggtcat 20700



gccagcagat ttaaggcgga ggcaggggag atggggcggg agaggaagtg aaaaaggaga 20760



gggtggggat ggagaggaag agagggtgat cattcattca ttccattgct actgactgga 20820



tgccagctgt gagccaggca ccaccctagc tctgggcatg tggttgtaat cttggagcct 20880



catggagctc acagggagtg ctggcaagga gatggataat ggacggataa caaataaaca 20940



tttagtacaa tgtccgggaa tggaaagttc tcgaaagaaa aataaagctg gtgagcatat 21000



agacagccct gaaggcggcc aggccaggca tttctgagga ggtggcattt gagctaagac 21060



caaaatgtgg tgggagaggg agccacacaa ggatctgggg gtgtgtgcac tgggaggggg 21120



agcagcaagt gcaaagggcc tgaaggtatg tagggggtgg agaagggaca ccactaattg 21180



ccttgggtgc ctttcaggcg tctccatgcc aaggctctaa cccctgatgt ggaagccaac 21240



atagtaatta taattatagt gaagaggggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 21300



gtgattgaaa gagagagaga atgagtctct gtaccttctc ttgggtctgt atgttgaaaa 21360



cctaagtgac cctaaagaag aatatttgca tattattaat tatgtagcta tacatgtttt 21420



ttttgagaca aagtcttgct ttgtcaccca gactggagtg cagtggcagc aatcatggct 21480



cactgcagcc tctgcctccc aggctcaagc catcctcctg tctcactctc ctgagtagct 21540



gggctacagg cagttgccac catgcccggc taatttttgt atttttttag agatggggct 21600



tcactttgtt gcccaagctg gtgcacatct ttattctttt tttttttttt ttttgagaca 21660



gagtctcact ctgtcgccca ggctggagtg cagtggtgcg atctcacggc tcactgcaac 21720



ctctgcctcc tggcttcaag tgattctcct gcctcagcct cctgagtagc cgggactaca 21780



ggcacgtgcc accacgcccg gctaatttgt ttttgtattt ttagtagaga cggggtttca 21840



ctgtgttagc caggatggtc tcaatctcct gacctcgtga ttcccccgcc tcggcctccc 21900



aaagtgttgg gattacaggt gtgagccact gcaccccgcc acatctttat tctttaggct 21960



tttgataggt ttgcttaagt aatgctgcta gcactgggca gatgtattac aataggaata 22020



ttgatgccct tgaactcctt ctagcacata cagatgtgac acaattcata tgcagttgcg 22080



gaaatgcctg tagttttctt taatggatgc ctataagatc caggctgtaa tctataagat 22140



cctataggct gtgtgcctat aagatcctgc tgtgaattct tccctgctgt ggctctaagc 22200



cagatgtata aatatatgta gatggataca ggtttatgct attcagccga gactctaggt 22260



caggcgatgg agatctgaaa ggtaagaagg agtctagaaa tgaattcctt ctggaaagat 22320



tcatgattca ttcttacttc tctgaactat agaagagcat cctcatcagt gaatgtattc 22380



gtcactgcat ccactgcaaa cccccttggg gaacactcac cttcactgtg cttctggatt 22440



tgcacatgtg cttgcatatg cacacacaca ctcacacaca cacattcaca ccatctttac 22500



tctgaatata caatgccaag ctttcccagg tattctaaaa tcctcctgtt tctgaccctt 22560



ggttggcaga tgtccaaaaa tgatactgac atcccaggtc agaatggtcg ccagttccga 22620



tcaagacaga gccccgtatc ttccagggac actagacaag atgccaggac cacgcctccg 22680



ctctgcccag aggccaaaag cagcccaaca aggtgaagtg ttctctgcat gcattactcc 22740



ctgggtcccc caagatcggc ctccagctct cctccaccca ggagctgctg tgtggagaca 22800



gagactggct cggggtccca ttccccaatc ccctcccttc catctgctat gccgctgcca 22860



gatggatttt actttctctg tttttttaaa aagcaaagtt caaaaaatat tttaaacaca 22920



ggaaatttaa tacgttagca ttttagctcc atctacagta tttctttatt ttttacacag 22980



ggtttcactc tgttgcccag actgcagtac agtggcacaa tcatagctca ctgcagcctc 23040



tatctcctgg gctcaagtgg tcttcctacc tcagcctccc aagaagctga gactacaggt 23100



gtgcaccact acacctagct aatgtttttt atttttatta gagacaaggt ctcactatgt 23160



ttcccaggct ggtcttaaac tcctgagctc aagtgatcct cctgccttgg cctcccaaag 23220



tgctgggatt ataggtgtaa gccaccatgc cccgcccata tttcttttag atataaaacc 23280



aatagaaaaa ttctatgtat ttctctttcc atgcctttcc ctccatggat tgtttccaaa 23340



ggcaacaatc catgttttca taccatccta catatattat ttataatcaa tatacaaacg 23400



tgcgttttta aatttcacat gcattttatc ataccataca tatgctgaaa ctcacctttt 23460



ttttttactc aaaattatgc ttttaagatc tagccatgtt ggattatttt aaaatcttga 23520



atggtattat attttatgac tataccacta tttgcttatc tatttttctt tttttttttt 23580



ttttgagaca gagtctcgct ctgtcaccca ggctggagtg caatggcgca atgttggctc 23640



actgcaactt ctgcctcctg agttcaagca attctcctgc ctcagcttcc tgagtagctg 23700



gaactacagg tatgtgccac cacacccagc taattttttg tatttgtagt agagacgagg 23760



tttcaccatg ttggccaggc tggtctcgaa ctcctggcct caggtgatcc acctgcctcg 23820



gcctcccaaa gtgctgagat tacaggcgtg agccactgcg cctggcctgc ttatctattt 23880



ttctactgat ttagtttgtt tccagtgttt tcaccatcaa acccaatgca ctaaggaaga 23940



tgcccgaatt tgtctcctga cgcgacatat gctagagttt cttcaggaca gagaggagtg 24000



agtgttctaa tacaaaaatc taatcatgct atttccccgc tcaaattcct ccatggaatt 24060



tattacctaa aaggtcaact ctaaactcct tagcttacaa gtacatgatc tggtatccat 24120



ctacctgtcc agccacgcat ttgaccgctg acttccttag cactttgttc tctgcaatat 24180



cgtatttctc ttaatttcta aatcgcccag ggggtttcaa gcctctgctt ttgcacattc 24240



tccttagtct gtctaggatc ccctcctcca actcctctgg cctggaaatt ccccttcaag 24300



tctccttttg aggagactgc ctcctccaca gagctgacca ccacgccaca tccaggctgt 24360



gttacaagat tgacacacag gctgaacgtg gccgtctccc ctctggacta tgaggctatt 24420



gaggacagga ccccagcctc tgcacatttg tagcctcagt gcttttgcac agggcttggc 24480



cagaatccgg gctccataaa tatttgttga attaatggat gtttggctgc tggggcatga 24540



tttgagcagc agaaatgaaa agcccagctt cctcccagct cagcagcagg caagaacttt 24600



gggacaactt ttccaaagca cttatttcat tcaagaccct ctgtagcttt gcaaccatgg 24660



cggggaacgg ggcccttccc aagaaaccaa gtccatgatt gtttaccctg gacattatta 24720



aacacccaca ttacaggtat ctctgtcatt tggccaacaa tttggtgtgt gatgttaggt 24780



tatttctatg tctgaagaaa acagctcagc tctgactaaa gaaataaatg ataccatttt 24840



tctttcaggc aaccagattc cttggtacaa aaggctccct ggggagaaat gccgggacag 24900



tgtggctcct ctgaggctat ttacatctgt cagcttctct aatctcttgc cttccttcct 24960



ctgtctgttt ccttcccttt gcacagagcc cggcattgag cctggtactt acagggaggg 25020



tggtggagcc atcgtcctca cgtatgcgct ggggatcggg gttggtgggg ggtggccagt 25080



ggcatttggt gggttttttt ttgttgttag aaaccagcct taatttaaga taataactct 25140



ccttgtttgc cagtgatcgc tatttgtagg cacctatttt ccctggtcaa tttggctaag 25200



ataaatcgaa tctaaaaggg aacattttct aaaaatgctg cggggcagtt tgcagaaact 25260



ggaccaagga acatcttcca ggtcacctgt tccatgatgg cctggatgcc ccccttctta 25320



aatgagattg ggggcataga aacagactcc ccagcctttt acgacaacac ctttaaagtg 25380



tcattgaaac ctgggggaac aaggaccctg aagaatcatt tggtctggac tttactgaaa 25440



gattccaatt cctgcatggt cagcccccgc cccctctcca actggtctct tgtcagtgtc 25500



ctcacaaccc ccagcccagc cctggctccc accctccacc caccctgcct gtctgttagt 25560



tcctcgaaag caccagctcc caattatgac gatgctgttc cctctgccag ggacactctt 25620



cttgcattct ctgccatcca tctgatgtcg gctcaaatat cacctcctca gaggccttcc 25680



ctgaccatcc catctaaaac aggattccac tattcttttt cctaaccctt gtcacaagtt 25740



gtcattttat atttgtctca tggcaggtct gcctccgctg cccagttgta agctctatta 25800



gacagggact gagctggctt gttcttgaga tctgagacca cagagcctgg cctgcagcag 25860



gtgctcagta tatcagtata tgttggcaac tgagtgaacc agcaaggggt cggtgggccc 25920



tggcacaatt gctctgctac cgctaacacc accactaaga atgtcattta aataccagat 25980



cataagcacc aactttagtt ccaggcagcc ctcctcctgg agtgggagca agagactctc 26040



tccacctcat cccccaggcc tggaaaaatg ttttgagctt tcagttgctt attctttgct 26100



tctttatgca caagttgttt tcctttcctc aatcgcttta tttccctttt ttctagtagt 26160



cacatcttca ttagagattt tatattacaa tatcattcat agactccctt ttaaatttcc 26220



ctggtccttc tgttgctgtc tggggagaca gaggtgcaca ctctgaagtc ggtactggac 26280



ccattcacac tgcccagctt ctgtgtggct gaccagccgt gtgtcattta ataccagact 26340



gtgtggctga ccagctgggt gtctccaacc cctcaggggc tccaccagac ccttggaatc 26400



aaccccctat ggttctccct tgggccccta tctcctgcat gcattcaact caccaaccac 26460



cacgtgcgcg gtttctgttt tctgtccatt tgcctaacgt ctcttgaatc catccatttc 26520



tctccagtgc cacttccctg gtttggccgc cgtctccctt gtcctggcct ctgatattct 26580



cctggcctct ggactcacct cctctaagcc agtcttcctc tgggcgcaga atctgatcct 26640



gtccctcctc tgcttcctgt ggccttagga tggagagcac tcacctcagc caggccccca 26700



ggctaaaccc gatctgatgc tcccagctct ccaagccctt ctcttctcag atgcctctct 26760



gggctcctct tagttcctgc aagtcccgca ctctctccca cctccggcct ttgggcagcg 26820



agtctttcag ctaagtggtt ttcctacatc accttctact ccctcctcgg ctctcataca 26880



tcctcctgga tgccccgctg aacctcctgg gccagttagg gccttcccct gtgttttcct 26940



gacagattgt agtttccctc atattgcctt ggtgaagtgc cctctaactg ccaatttatt 27000



attattattt tattattatt attattttga gataataatc tcagagtctt gctctgtcac 27060



ccaggctgga gggcagtggc atgatcttgg ctcactgcaa cctctgcctc ccaggttcca 27120



gcgattctcc tgcctcagcc tcctgagtag ctgggactac aggcacatgc caccacgcct 27180



ggctaatttt tgtattgtta gtagagatgg ggtttcacca tgttgtccag gctggtctcg 27240



aactcccgac ctcaagtgat ctgcccacct tggcctccca aagtgctggg attataggca 27300



tgagccacta tgcccggcca ccaatttatt atttcttccc ttagactggg agcttcatga 27360



gggcagaggc tggctgtcat gctcaggggt gcagagaaga tcctgactta aaattcctgt 27420



gacttggaca tgcaggagaa gccagacgtg aaggatataa attgaaccaa cttggactga 27480



agatcccagc caggaggatc tgctccccca ggaagggaac tgatttgtcc tcgaggcccc 27540



tgggatagga gaagccacag catcctgttg tttgatcttc ttatcttcaa gcaggcatga 27600



ctcggttcca gaaatacaag ccataagata gacctccaga ctcctagaga cgatctgaag 27660



ctgcagaagc cctccactga aagaccggac ccactgccta ctcctcctgg caggtgccct 27720



ggacaagggc acagacttca cagcgttcaa gtgtgaaggg attgtccttc tccagccctg 27780



gatattaaaa ggtctacccc gatgagccat ggagggactc tgagtgtgtg tgtgtgtgtg 27840



tgtgtgtgtg tgtgtgtgtg tgttggagga gttgcttatg gaaaatattt ttcctgctct 27900



taaaaaggga ctcctgccag gcatggtggc tcatgcctgt aatccaagca gtttgggagg 27960



ccgaggcagg tggatcacct gaggtcagga attcgagacc agcctgacca acatggagaa 28020



accctgtctc taataaaaat acaaaattag ccgggcatgg tggcacatgc ctgtaatccc 28080



agctactcgg gaggctgagg caggagaatt gcttgaaccc aggaggcaga ggttgcggtg 28140



agccgagatc gctccactac cctccagccg gggcaacaag agtgaaactc tgtctaaaat 28200



aaaatttaaa aaaagaacaa aaagggactc ctggctgggc atggtggctc atgcttgtaa 28260



ttccaatact ttaggaggct gagtcaggtg gatcacttta gcccaggagt tcaagaccag 28320



cctggtcaac atggcaaaaa atacaaaaaa aaaaaaatta gccaggaatg gtggtgtgca 28380



cctgtagtcc cagctactag gcagactgag gtgggaggat cacctgagcc tgggagtttg 28440



aggctgcagt gagctgtggt tgcaccaccg caccccagcc tgggtgacag agcaagaccc 28500



tgtctaagaa aaaaaaaggc gtgtagcact tccctcctct cccccattat ctcccttgct 28560



ccccctctcc atgtgaggtg ctggcttccc ccttcacctt ttgacatgat tggaagcttc 28620



ctgaggcctc cccagaaacc cagcagatgc ccagcaccat gcttcctgta ccgcctgcag 28680



gaccacaagc caattaaacc tcttttcttt ataaattacc cagactcagg tcagtcagcc 28740



ttccttcctt ccttctttta aattttttaa ttttgagaca gagttttcct ctgttgccca 28800



ggctggagtg tagtggtgca atcttggctc actgcaactt cctcttccta ggcttaagtg 28860



atcctcctgc cttgggctcc caaactgctg ggatcagagg catgagccac cgcatctggt 28920



ctcagatatt tctttatagc aatgcaagaa tggcctaata cgggtgacaa gtcagagttt 28980



gcagggaagc ccaagaagca agcacatcag ctgcctgagt gaggccgtga agggagccgg 29040



tggacaggtc tgcgggcagc tgtagctcag caagcccagc tggccagaac acgggccaga 29100



ccgggagcca gcagcccgag aggtggattg gccaggcata tctctgcctc agtgtcatca 29160



cggcacatga ccgtgacaac cccctgagag tcaggatgct gcttcacttt tattttccaa 29220



atctcatgca agctcctctt ttgaccaact ctaccctaga cccctctgga gaaggggttt 29280



ctgggaagta ttattcccag attagccaaa tggacaaaac acaaaccagc aggaagacca 29340



gccccactca tctctctggc ctcctcccct ctactcccta cctgtgccca ggccctaaac 29400



tgtttacagc tccccattgt gcctctgccc atgctatgtc ctcaatttgg gatacctctg 29460



ctctcttctt tagctagtca atgctactga gccctcagga tctggcccca gagactcatt 29520



ccctgagaca tcttccctct ctgagaactc ccctctcctc tgtgctcccc aagaactggg 29580



tacaaaccca cattgcaact cctgttaccc accgagtctt cctcctcgcc agggctagga 29640



atctcttggg aaggaggact gtgtctgtgc tggccagcct cccagcagct agtgctggga 29700



aggcagggtt ctcaaggagg gcgcaatgcc ctcctggcat ggaaaccact aaaccaccgg 29760



tgcagtgtgc ttcagaatca cgtagggaac gtgttacaca ttcagattcc cagtcctcac 29820



ctccccgaga ttttgatttg gtagttctgg agctagactc aggaacctgc atttttcttt 29880



tttttaaatt gggcagcctc tagagccaga gtaggctcag agactcccag gaaccagcat 29940



tttttagcaa acactgtgag taattcatga gcaatttgtc taccacatca ggctgactct 30000



gacagagctg aatctttttt tattttttta agagtttaag tctaactctt ttcatttttt 30060



ttaaccttag tttctagtta gattagaagg tctgtctctt ttatagataa aagctctatt 30120



aagtccttat aggtcttatt ctgcttttat tggaggccct gaagcccaga ctatgggatt 30180



taaaagtctc tgaagggtga cagagaggac cagagagaag gcagtagagt cgaggcatgg 30240



agcttgccga gggcctggcc gggacagaga ggcccagcaa cgccttggcc ccaagaaaat 30300



cttcttgtct ttctggaatg ccgagaagcc ctgaggaggt cctgggtggg aagagctaag 30360



ccatagtagg tgtgctgagg cccatgggag gggactcagc atgtgcctca gtagcccgtg 30420



acgcgggacc tcccacgcgg gtctcctgag gagctggaga gaagcagatt attcctccaa 30480



catatcagtg agggcacctt gggcccaact ggctggggag gtggggatgt gtggggtggg 30540



gacgggatga cagcagagga gctggcacta ggacaggagc cacagcaggc tgggtaccac 30600



agagtggggc cttgccagtt tcgacatctg tccccagtcc ctgcctggtc acccaaggaa 30660



tgtggcttta gatttgtggc tcgggacccc aggagaggga gagggagcct ctcagcctgt 30720



ctagatcttc ttggccaggt ggtgggaggt ggcttctccc aggggccccg ggggctgctg 30780



gatgagacgc tgactcagtt atcttctgag ttgagccatt gttttattta aaaatacaga 30840



gcaaataaac ccacaatatc actccacccc atggacacaa gcactactta tatttaggtg 30900



taaccccttc cagtcttgtt tcctctgtgt atgtgtgtgt gtgtgtgtgt gtgtgtgtgt 30960



gcaggcacat gcatgtgttt gtttgtacca taggtccata aagttctgta ttctgtatga 31020



caccattagc attttctatg ttgccacaga gtctttgtga ccatcattcc caaaggctgc 31080



ctggtctact gagatgatgg gccatagttt ccttaaggat cctttgttgt cttctgaccc 31140



acacaatgac actaagtttt acctggggcc agactcccgc tccctgaagt cagccctgtt 31200



caaaccccaa atcttggccc tctcaatcca gtccttcact ccctgacctc ttcctgcatt 31260



cttctgcctg ctccagactt tttgatttac ctcccaattt atgtatcaca ctcaccaccc 31320



ccctagatct gacagcttag ataatgcctt cttgaatact ggaaaaacct gaattgccat 31380



cagtttttga ggttcctaat atactataaa atgtaaatat gcctaaagag ggttataaag 31440



attgtcagct attttaggct gggtgtggtg gctcacacct gtaatcccag cactttggga 31500



ggccaagggg ggtggatttc ttgagcccaa gagttcagga ccaaccttgg caacatggta 31560



aaatcccacc tctacccaaa atacaaatat tagccaatct cttaacccag tctcaaaaca 31620



aataaataga ttaaaattaa aaataaaaga ttgtcagcta tttcagtgtt tacactgaac 31680



aaattaatat tcctttcacc agtaatgtgg tataacattg ttatgaaccc ccaagaaatg 31740



tacaaataag gtaccacacg tgataccaac tctccagatg tggagacaag gtcaaggcca 31800



aatgacaaat gttctctttg ggtcttgtca gagtcactct ctgagactaa atatgcaatt 31860



gcacttgaag aaaaaaatag cagaagtcta aatttgagac ccattgagac ctgagccaat 31920



ggctttccat actccccttg tgtctgcacc caattaaaaa caaaataaaa caggttatcc 31980



tggctgcttc tctagaactg tcccttggcc taccttgtca ggctgagcct ggcacctgtc 32040



ctcagatctg atgccttgtt gcctggagtg cctcccccac ccactcaacc ctagctcctg 32100



ggatcctgcc ttgggtcagc ccccttggct ggtaccagag gtgtttggaa cattggatgg 32160



cttctaatgt tttcactatc gtaaatgtgg tggatgggat tctctggttc tgtcagctcc 32220



ttttccctct ctatgctcat ccttactgag gagggaacat tttaagctca cccctactga 32280



ggagggagtc ttttaacctc ataaatcatt agagtgatac atcaagaatc cactctaagc 32340



agagaagtgg attatctcaa ggcccctcca ctcagaagat gggaggatgt ggagcaggtg 32400



gttctatttg ccttgagcac aagggccaca gggagcaatc cagatttgct ggctactgac 32460



caaaggggat gaagctcctt ttctaagaga agaaggttag acaaggaagg agatgagaga 32520



gatcaaggga aacagagatt actgggcatc atggaagctg ttttctggaa ggcaacccag 32580



tgggaagggt ggggacgctc tgcatcatga atgagtggag gtgatacttg ctggcagtag 32640



attcagcttt tatccatttc tggccacgga agggcagaat gtggccatga atgactttgc 32700



tcaaatacat ttttctctac ttaggattat ttcttttccc caagggggca catttctatg 32760



gctcttctca tatattgctg gattggtttc tagaagatgg gtatcacttt acaatagggc 32820



aagagaggat cccatttttg gcacatataa gtatgcaata agtaagtgat taatagcaag 32880



cagaacagaa aatccccagg ctgtggggca gtggtgctgt tgctggaggg agaacatcca 32940



gatctttaac ctctggggcc acttcaaata cacttgccca ggatttaagc atcattagta 33000



gatgttgctg agccaaatcg ataaatggat atggcaaagg ctgtgtagat tttagagcag 33060



ggcagatggg atgcaatttt caggaatcct acaaggccta gatgtaacag tgtgatcctc 33120



agggcaggac ttaattcagg accctgccat cagaagtgaa atgaagcact aatatatccc 33180



acgacatgga tgaaccttga aagcatgcta agtaaagaag ccagaccaaa agaccacata 33240



ttatatgact ccacttatat gaagattcct gcagcctcta cgctccacca ctgataactc 33300



cctccagatt caaattcctg tgggcctgcc tgctctagct ggggccggga tgggaggtac 33360



cagaacccca caactgacac ccccaacagg gctgtcagga gagaggtaat ttgctcaaag 33420



aaaaatttag atggaggcaa aagccacagc tctccactaa ccacgctgct aaaactttgg 33480



gggctgctat gcaccagaac tagttgaaac catagagcca caggccaaat ctggcccacg 33540



gcttattact ttacagccca tgaaggaaga atggtttttg ttggtgttgt agttttgaga 33600



cagagttttg ctcttgttgc ccaggctgga gtgcaatggc gcaatctcag ctcactgcaa 33660



cctccacctc ccgcgttcaa atgattctcc tgcctcagct cccaagtagc tgggattaca 33720



ggcatgcacc accacgccca gctaattttg tatttttagt agaaacgggg tttctccatg 33780



ttggtcaggc tggtctcaga ctccctgcat caggtgatcc gcccgcctcg gcctcccaaa 33840



gtgctgggat tacaggcatg agccactgcg ctggccggaa gaatggtttt tacagatgaa 33900



tatctgcaat tgatttgatg acagggaaca ccaactttga atcccaatta agtaaaatgt 33960



tgccctccca atcctgcaaa aaacaaaaca aagcaaaaaa caaacaaaca aaaaaacaaa 34020



aaaaccaaac acattcttct cattagtaaa cctgcattac aaaaaactgt tcctggcagg 34080



actcagtgac tcatgcctat aatcccagca ctttgggaag ctgaagtggg aggatcgcat 34140



gagcccagaa gtttgagacc agcctgggcg acacagggag acctcatctt tacaaaaaat 34200



gtaaaaagta gccagtgtgc tggtgcatgc ctgtagctcc aagttacttg ggaggatcac 34260



ttgagcccag gaggtcaagg ctgcagtgag ctatgcattc aagcctggga gacagagtga 34320



gaccatgtct caaaaaacca aaaaccaaca aacagaaaca accctgttac caattattat 34380



tattatattt ttcaatttgt caataaaaat gtttggaaat ttgtttaccg tcttatcaag 34440



taagtgctta cctaacatcc tcagttttga ctcttggcct gcaaacccca atatttacta 34500



tctagctgtt tactgcccct tactctaggg cagtgcctct caaattgtgg tgatcataga 34560



atcacctgga gagctgttaa aacagattgc tgggccgtag tcccagatac tctaattcag 34620



taggttaaac atagagttta ctatatgaca cgtcaattcc actcctaggt atatacccaa 34680



gagatttgaa aatatgtcag tacaaaaact tgcacatgaa tgttcatagc agcattattc 34740



ataatagcca aaaattggaa acaatccaat atccatcaat tgatgaatgg atatacacat 34800



tattgtatat ccatatgagg taggaagtga gactcgactc cagagatgaa gtcagacacc 34860



aaactgcgga ctagctaaaa caaggaaggg gcagaaccag ctttccataa gatatgccca 34920



ccagtgagcc atgtcagttt accattgcca tgacaacacc tgggagttac cactcctttc 34980



catggcaatg acccgctgac ccaaaagtga ctaccccttc cctagaaatt tctgcataaa 35040



ccacccctta atccatatgt aattaaaagt ggtataaata tgactgcaaa ataccctgag 35100



ctgctactct ttgcctatgg ggtagccctg ttctgcagga gcagtcacag agctgtaacc 35160



actgctgctt caataaagct gtcttctacc tctggcttgc ccttgaattc cttcctgggc 35220



aaagccaaaa atcctcatgg actaagtccc aatttggggt tcatctgccc tgcatcacat 35280



acaatagagt attatgcaat tctgaagtga aatgaagtac tgatatatcg cacgacatgg 35340



atgaaccttg aaaacatgct aagtgaaaga agccagacca aaaggccaca tattatatga 35400



ctccacttat atgaaatgtc cagaataggc aagtacatag agatggaaga gagattagtt 35460



gttgtcaggg aatgtaagac agtggaagtg gagagtgact gctaatgagg acgaagtttc 35520



ttttttctgt catgaaaatg ttctggaagt agtggtgatg gttgtacagt cttttgaata 35580



tactaaaacc actgaattgt acactttaaa atggtaaatt ttacggtatg tgaattatat 35640



ctcaatgaga aaataaataa ataagacaca caacccatga cattggacgc aatctggaac 35700



tagttctcag aaaatgattt tgcttgatgc ataatatata ttaaagaaaa aagattgcta 35760



cttctttgag ggcaattaaa ttttttcgct agcatctctc tacattttct ttctcatcaa 35820



agtcaatgag aaaacagaat tcctgaaaag aaactttgct actaacaatt aagacctaaa 35880



actatcagta agttaaggac acgacaatgg ggctcttgga atcaatgaca gactcggacc 35940



ggctgtttta actgacttat catgaaatga atgatgacag aaacaataca atggaaatta 36000



tttttcatgg aaagaattca tggcaccctt tgtgtttgtg actggaatga ccacggatgt 36060



ggttcagtct gaatgtgtat ctgcagccac aaaacagatt tgagcttttg tcttgcaaaa 36120



tccatctgaa catattggct gcattcgctc agcccagaga ttaagtcatc atcttgggca 36180



gggtttcagt gaaggctaaa tcagatccag ggagagagag agcaggcagt gccggtgcct 36240



atcttgcagg ggatgcccca gaaaggctga aatacaatgc cccagtggct agctgttgct 36300



ggaaagaagc aagctggagg gcacagaagg tttaaaaaag ggggctcctg aatgtcactg 36360



ggttccccaa acctccaaga ggaagctgta cccagattct actgccatcc tcttacggtg 36420



gaaagcaaag gcttgggctg tgtatccctc caggactcct ccatgagccc tagtgtctgc 36480



agagggtgtg gtccaggaag aagcaactga ccttctgctt ccagaagtga ggatttcctg 36540



tagctcctag gcctggcctg ccctgggatg gctccaaccc taccaatata tgtgagttcc 36600



tttatagctg ctgtttattt ttgaaaggaa gcatctttgg tgaccagcat cacatgtcaa 36660



agttgagagt gcatgaccaa aagatcctgt gactcaggga gagctctaga tagcctttat 36720



ctctgcccaa ttattcttcc agaatctcag ttagtgatcc tgtcattcat cttctcataa 36780



accttctatg gctccccacc accaaccaaa ttaaatccaa gtctggaaac aggcattcat 36840



gaatccagct ctgcaataca gcagtatata cttttgcagt gtcaactacc tggagttagt 36900



acagactcca caggttaagg acatagtctt caacaagact gccctcactt cagagacccc 36960



acataatatg gggtccccag gctacctgca tttctgatca actggctaca aatttggggg 37020



ttcccacaac ccctcatatt tgataatttg ctacaatgac tcacataact cagcaaagtg 37080



ctatacttac cattacactt ttattataaa gggtacaaat caggaccagc caaatgaaga 37140



gatccatagg gtgaggtctg ggaggatccc aaacacagag cttccatatc ttctccccat 37200



ggagtcagga tgtatcaccc tcctagcaca ctggtgttca cccaccagga ggctcaattg 37260



agccttgagg tccagagttt ttattggtgt ttcatcacga ggcatgattg atcaaataat 37320



tggccatgtg attgaactca atctctaacc tccctggaag tcaggctgat ataatctggc 37380



tcaaaacccc aaccctctaa tcatttggtt ggttcctaat ggctagtccc catcttgaaa 37440



ctatctaggg gcccaccatg agtcaccttg ttagtatgaa ctcaggcatg gtcccagtgg 37500



ctcactatga ataacaaaga cattcctatc acttgggaaa ttccaagggt ttagaagcta 37560



cctctcagaa acccaagaca actggagaaa ttattatgca acaaatgcca gcctatcttc 37620



accacagtgt gccccatgac cccttttcta tgctcttggc ttaggtcagg cagagcagct 37680



tgcggctctc catgtggacc tggagatttt tcacctcgct tcctttgctt gcactgattc 37740



ctttgtctgg aattgcctcc atgagggtac ccatccttcg tgtagatata actgtcctca 37800



ttttagatga gaaagttgag gactagaaga tgaagtcact tttcaaagac aattggatct 37860



atatgataaa accaggccat aaatccaggc ctatctgaag ccccaacctg tgtgatccca 37920



cttccccatg ggcagtagga ttggctgata ttattgaaat cccttaaaga tcattctgta 37980



attattctcc catgaaaaaa tggcttaaag ggggcaaaac ttgccatcac taacaatgcc 38040



accttgggga agctaaactc ccaaattaac agataccctc aactgcaagt aatagaaagg 38100



cccacaaaaa gacccttaga ccaggagctg gcaaactttt tctgcaaagg gccaagggcc 38160



agagagtaaa tatttgaggc tttgcaggcc ataaggtctc tgtcatgact atgcatccct 38220



gccattgtag cactaaacaa tatgtagaca atacataaac aaatgggcat ggctgtattc 38280



caataaaact ttatttacaa aatcaagcag tgggccagac ttggctcctg ggtcatagtt 38340



tgccaaccct tgtcttaaac caggaggaca tttattcacc atataacaag aagtctagaa 38400



atagggtgga tccaggtgag ctactcaggc agctcagcag catcttcaga tcctaggttc 38460



cttcctgtta tttgcagatg acaacatcca gaaacagaaa agttcatgcc tccttggtca 38520



gaatagttca caggctaatc cctggctaat gggaaaggag ttatccagat tgccttagac 38580



aaatggtctc atccctggct gcaacattag aatcacctga gagcttttaa gaaacacctg 38640



ggcccagctg ggcacagtgg ctcacacctg taatcccagc actttgggag gcggaggtgg 38700



gaggataatg aggtcaggag attgagacca tcctggctaa caaggtgaaa ctccatctct 38760



actaaaaata cagaaaatta gccgggcgtg gtggtacgca cctgtagtcc cagctacttg 38820



ggaggctgaa gcaggagaat ctcttgaacc tgggaggtgg aggttgcagt gagctgagat 38880



tgtgccactg cactccaccc tggcgacaga gagagactcc gtctcaaaaa aaaaaaaaaa 38940



gaaaagaaaa gaaaagaaaa gaaacacctg ggcccctacc agagttttgc atttaatggt 39000



tatgaggtgg ggccttgtca ttgatatttt ttaaaaccat tcatagctgg aaaggaaagg 39060



cattggcaga ccagtcaaaa ctcactgcac gcaaaggcca attcatgatc accatcaaaa 39120



aagtatttta gcaaggagga agaagggtct attagtccat tttcacactg ctaataaaga 39180



catacctgac attgggcaat ttacaaaaga aagaggttta attggactta cagttccatg 39240



tgattaggga agcctcataa tcatggcaga aagcaaggag gagcaagtcc cgtcttacat 39300



ggatggcagc aggcaaagtg agaatgagga agacgctaaa gtggaaaccc ctgataaaac 39360



cataagatct cgtgagactt attcactatc acgagaacag tatgggggaa actgccccca 39420



cgattcaatt atctcccacc aggtcctccc acaacacatg ggaattatgg cagcacaatt 39480



caaaatgaga tttgggtgca gacacagagc caaaccatat caaagggcta aggctgaagg 39540



gccacatctc aatgtgatgc ttttcacttg caaaatggaa atcaaggtag gacctacttc 39600



aaaagtccct gcaaaattta aatgaagcag catgcctggt acagtgcctg gaaaaaataa 39660



gcactcactg cattaacagt tgattgctct taatcattat gaagtcctcc tagatgtctt 39720



atgtacattt tagagaatgt accaattgaa tgatgttggt tttttatggg atttgaaccc 39780



cagcctttcc tcagctatct ggaaaactgg gagtggcagg tatttaaaaa aaaatacaag 39840



tgactcacca caacacttcc ctcccaaata tttcatgtaa gaacacagca cagagatcaa 39900



ttgatctcta ctctctcctg aaaagcatca tggcacaaac actttcctga gggccgttta 39960



gaagcctcac tcttccttag tcatagaaga agactttctc ccccgttccg ctctgggcca 40020



tcttctcccc gtttccccat ctatttctag ccacttttca aagcaaagtg ggaaatctct 40080



cttaatgctc cttttcttcc ttctactagt tttctatggc tgctgcaaca aattaccaca 40140



aacttagagc cttaaagcaa cacaaattta tgaccttaca gctctaaagg tcacaagtgt 40200



aagatgggtc tcatggggct aaaatccagg ttccagcagg gctgtgctcc tatctggaga 40260



gaccacatat cctcgccttt tgcggatccg agaagtggcc tgcattcctc ggcttgtgac 40320



cccttccacc ttctctcatg gcactccctt gactcaccct tctaccccta tcttccacat 40380



ctaaggaccc ttaaatgtga tgacactggg ttcccccaat ccacctggat taatctggat 40440



aatccagaat gatcttcaca tgtcaggatt cttaacgtaa tcatacctgc aaagtccctt 40500



ttgccacata aggtaagata aggtaacgtt caaaagttcc agggatgtgg atgcgaacat 40560



ctggggacca ttattctgtc taccacattt tgtgatctct aatgctcccc attcctctcc 40620



agcctctcgt tcctcctttt cacctatggg gctctgtttg tcctctccca tttgccgtcc 40680



tgcaagatcc agatggcctt tcctgaaata gaggcacggg tgtcctggca tgtggggctg 40740



ttgggaggtt tagattaatg tttatgagtg cttagaacag tgtctggggc acagtagggc 40800



tacaaaagtg gttgttagct gccactgttg ccattaacgt gctcacaggc ctgccctcct 40860



tgggaatggg acttctactg gccttcctaa agggtgccta ctttttttta agcttgaaca 40920



attcaaaaac agccagtaac ttggaacagc tttctagaaa ctatcaacca tggctgggcg 40980



tggtggctca cacctgtaat cccagcactt tgggaggccg agacaggcgg atcacctgag 41040



gtcaggagtt cgagaccagc ctggccacca tggcgaaacc ccatctctac taaaaataca 41100



aaaattagct ggtcatggtg gcgcacgcct gtaatcccag ctactcagga ggctgaggca 41160



ggagaattgc ttgaacccgg gaggtggagg ttgtggtgag gtgagatggc cccactgtac 41220



tccagcctgg gccgcagagc gagactccat ctcaaaaaaa aaagaaagag agaaacttta 41280



tcaaccagtg tttcttcaag tgtccaccca catcagcatc tcctggggtg cttttaaaag 41340



cacatttgac tttagttctg ccctctaaag tttgtgaacc tcagtctgga actccagcat 41400



ttgggggttt ataatttgca accagaacaa aaaagaaaag ccccatccca ctgcctcact 41460



cagcccctct gctgctaaca acacactcac tgcagggcca ggggctgaag tctcccttga 41520



aggatgttcg gcaaggctgg ggccttcctc agggacccgc cattgaatgc cagcgaaggc 41580



cttgtcccaa gaacaggggt tgaaggcagg aaatggatgg gagggaggta gacagtgact 41640



atctgaccaa tggcatttat ccttttggag gtccctgacc ctctcaagaa cctggtgaaa 41700



gccaaaggtc tcttctcata cctgggcacc aggtatgggc agctggcccg atgactactg 41760



agaggaaaag aggaagctgg agctcccggc cagaccatgg tccaacctgt agctctgctg 41820



gccttagtat gagcagagga tgcaaaagcc agaaagaggc ccaactgtca aagcttcagg 41880



acacgcgaag tagagcttcg tgtgagctca gctcccaccc tgggactcct cagttggtgt 41940



taaggaaact tctaagccct agaacctgca aagaccccag gccctgctgt ttaatgaatg 42000



gaaagaatct tcttccctcc ttttgaggca ttccaggcct ttccagagcc cacccgatac 42060



ttaaataagc accccacggg gatggtgtgt atccagaact aaaataaact taaataatat 42120



cccagaaaat tataaattat gtatttagga atcggaatgt gcgaggcagg gttttctctt 42180



cctctattat agctttcatg aaagggagac aaataataaa gctcccccgg gctaaagtta 42240



gagtcgacat atagtttaca ccagaaaata tacacttagg tatccatttt gaatgcatgt 42300



acttccagtg caaaatcctc tcagtgacca caagctcctt aaagccaaag ccaagagcag 42360



ggaggtctct gtgtggtcca aatgctcagg aaggaaggaa agtagcatct attgaacgtt 42420



taccacccac ctggcacata actcacgccc tcttacaacg tcctcaaaac tacactgtga 42480



aatttttttt tttttttttt taggcagagt ctcactcact ctgcactcac ccaggctgag 42540



tgcagtgatg cgatctcggc tcactgcaac ctccgcctcc caagttcaag caattctctg 42600



cctcagcctc ccgagtaact gggactacag acatgccaca ccatgcccgg ctaatttttt 42660



gtattttttt tagtagaaat gaggtttcac cacatgggcc aggctggtct cgaactcctg 42720



acctcaggtg atccatcccc actttggcct cccaaatgct aggattacag gcatgaccca 42780



ccacgcccgg tgaaatcaat tttattagct ccattgttca ggtaggggaa aatgaaactt 42840



ggaatggaca agtaacttgc ccagcattgt ggggaacaat accatgagcc tgaaaccaat 42900



ttccctaatg atttatttgc ctagtcacct atttcatctt ttagcatcct agttttccct 42960



aatcttttgg gtatttgaag aactctatta aaagctaatc taaagatata tatttttggc 43020



agagtacggt ggctcatgcc tgtaatccta gcactttggg aggccgaggc aggcggatcg 43080



cttgagtgct ggagttccag accagcctgg ccaacatggt gaaaccccgt ctctactcaa 43140



aatacaaaaa ttagccaggt gtgtgagcag gtgcctgtaa tcccagctac tcaggaggct 43200



gaggcaggag aatcgcttga acccaggagg cagaagttgc agtgagctca gatcatgcca 43260



atgcactcca gcctgggcaa caaagcaaga ctgtctcaaa aaaaaaaaaa aaaaaaaacc 43320



cacagatgcc cgggcttcgc cccagaccaa atgaacccaa atccctcagg gtggggccaa 43380



gcatcagcgt tttcacctat tctccaggtg cttccacacc ccaaggtctg aagcccactt 43440



ctctatgaca tctcttggag gcgggttgtc tgcatgtctt gtctcacctc ccaatgcccc 43500



tccactggcc cctggggact cagaatcaag gaggggttta ggagtcccag tcactgcctc 43560



tggatggtta ccatacctct tgccctctat ttctgccctc attatagaga tggtgagtgt 43620



ggctgcccag ggactgctag atgattagag ctcaatcatt ccttcccaac agagggccat 43680



tttttcttga gaagtgcagg tttgctggat taacaagcta ccctggcttc ccaggggtta 43740



atgctgctcc ctcagaggtt gcctgtctga gggtgctgac cccaccgtgc tcctgttggc 43800



ccaaggagtc tcatgctcag ctggacattt atgcctctgc tttcctggcc tcactaggtg 43860



ggtgggggct gcttctttgc aatctggtgt ctcccctgct gggtgacctt gggaaggtct 43920



cttaacccct ctgagcctta gtattcccct gcaaaataga aaggatggtg cctacctcag 43980



aaggatatta tgaggattaa ataggtctcc acgcactctc agaacaccct aagtttttca 44040



ttcaaagtat gtatattaat catcgtttaa tgtttgtctc tagctggact aggagaacca 44100



ctagggccag gcctgtgtcc atgtcccaga atcttaacac agggcctggc acctcgtagt 44160



tgctcataga ccccttgttg aataaatgaa taaggatggg cagggcaagg aatggagtct 44220



gttgtcgatg agtcttaatt cctttccttt acttccctaa gatacttcca gaacaacctc 44280



cgcagatgta tattcttttg ttagcagtca tgcatgtcag caacttcctt cacccaactt 44340



ccttcaaaca agggtcccca ccacacactc actggccttc tcagtggtct tctggtggga 44400



acagatgtgg cttcattagt ggccgggcag aagcatggat atcagagact taaggggtac 44460



caatccagca ggttaagatg gcacagctat ctgtggctgt gtaacaagcc accccaaagt 44520



tggtgacata aaacaacaac cattttatta ggctcacaga ttcagaggtt taagaatttg 44580



gccagggccc aacagggtgg cctgtctctg ctctccaatg tctagggcca gggttgtgaa 44640



gactcaaatg gctagaggtg gctggaaagg ctgagggctg aaatcacctg ggggcttctt 44700



ccctcacatg cctggtgcct ggactgagac atctcagtgg ggactgtcaa ccagagtgcc 44760



ttcacatggc ccctctgtgt agtttgggct tcctcacagc atggtagcct tgggatagtt 44820



gaacttttta cctggaggct caggactcca aaggcaagtg ttccattaac aaaggcagaa 44880



gctgatggcc tgagatgact taggcttgga agtcatacag catcacctct ctgtactcaa 44940



ttaattgaag cagtcataac cctgccaata ttcaaagaaa agagagaaat agaccccaca 45000



gctcaatggg aagaccatca aagaatttgt ggccatattt taagactatg acacataccc 45060



tgctggttgc agttgcatgt gctagaacct gagacagggc ctggctcagg aggagggctc 45120



aggaggggct taccaagtcc caggctcttg gcccaatgct gtgtggcctt aggcacactc 45180



actcatgctg tgtggcctta ggcaagtctt ttccaccttc ttgacctccg tttccccatg 45240



tgacattcag agaataaaat gctgcaagat caacctctga tatggtcagg ctttgtgtcc 45300



ccacccaagt ctcatcttga attgtaattt ccaggtgttg agggagagag ctgctgggag 45360



gtgactggat catgagggtg gttcccccat gctgttctgg tgatagtgag tgagttctca 45420



ggagatctga cggttttata agatgctctt cccccttcac ttcctacaca ctctctctca 45480



cctgccacca tgtaagacat gccttttccc ttccgccatg attgtaagtt tcctgaggct 45540



tccccagcca tgtggaacta tgagtcaatt gaacctcttt tctttataaa ttacccagtc 45600



tcaggtattt ctttatagca gtgtgaatat ggacaaatgt aactcctttc cttgttgctg 45660



gagaccctca ccatcatgca catacacagc tcaccaggga gacagagatc ccaatagggt 45720



ggggagcagg caccaacaga atcctcccaa ccagttggga aaataggagt gcaaaggaga 45780



ctgtgtccac tgtttatctg gaatgctgag tgggtggagt cctgttctat catggcaccc 45840



agggtcaatc agaacttccc tgggtcccta tagtatgagg ggccagctag ttttccaaca 45900



cttccaagga aggcatggaa ggtgctgggc agggcctggt gggctgggag ggcctcagct 45960



gcagagtcag gaggacacag agtgtgtggg ctaattacta cagaaaaaaa agatgtggat 46020



ttagcagaca ccaacaaaat ggggtgacca tgcccaagag gttagtgaag acagatactg 46080



atgaccatgg ctcggctctc cccctcctcc agctccccct cctatggcac agaagccact 46140



agaactaagt agatgacctg acaagggaag ttgaggcaac tgggaataga ttgaatttaa 46200



gtctgatatg accaacttca gctgacattg attattaaat aaacttaaat gtttttggca 46260



gttggacaga atggggagtc tataggagaa acagaaaaat gaagctgtgt ttttagaggc 46320



cccaagattt gtagctaatt catttcttct ttctgcttag caagggactg gctgagatct 46380



caggcctttc cagctgtgat atccagtgtg gctctgatcc ccaggcttta tgactctgct 46440



gctgctacca ctgcatccca ggggactgcc aaagtgtgtg caggtcacgt cccagtgggg 46500



ctctgcctga cccagcactg aaaaatggtt tacccctgag tcattcagac aattgatatc 46560



gttgagaaac cacggtgtgt aggccctagg ctgggcactg tgcctgcttc tggggacagt 46620



caattgaata agacactggc ctcatcttca acatgtttac aatcctgtgg cagcaaacaa 46680



ttagaagcca ctggttctag gaccttaatt aggaatttct cctgattact gctttcgtta 46740



aaaagacatg agcacatctc cagctaatca gtcaacaaat atttattgag cacctactat 46800



gtgccaggct ctgttttagg tacttggggt acatcagtgg aacaaataaa cagtagaaat 46860



ataaataaat gagccttgaa ggcctgcttt tatctctctg cccatctcgg tcctggggaa 46920



ataaatgtgg gtgtttcagg ccgaacatcc aaatgatcaa cttttttttg agacagggtc 46980



tccttctgtc tcagggtctc ctccttcacc aggctgaagt gcagtggtgc aaacacagct 47040



cactgcatcc tcaacctcct ggactcaagc aatcctagca cctcagcctc ctcgtgtaga 47100



tgggaccaca ggcatgtgcc accacaccag gctaattttt aaattttttg ttaagaaaag 47160



gtctcaccat gttgtccatg ctggtctcaa actcctgggc tcaagtgatt ttcccgcctc 47220



agcctcccaa agcactgaga ttagaggcat aagccaccgc aacaggccat catcaactta 47280



attctaaggc atttcccacc cccaccctca ttccctgaac tcccatcctc ctttgatcct 47340



cagtcaaggc caacttcgaa aactccttgg taatcagctg ggagcttgca ggtcccagac 47400



cttcagcagc ttgtgggaat gtcccatgag gaactttttt tttgtcaaaa gaatgccagg 47460



agtttaatta ctgtgtggcc catggaggtg atttccattt atcagccaga acccagacag 47520



atcctaggaa ggcccatcat gtgaggctgt ggccgccgtg gcctgctctc tccagcaaag 47580



gataaccctg gggcctgtgc cctgggcagg ggcagcagga atgctttgaa tgcttcccct 47640



gcatgtggcc ttgggtttta ccaatggcta cagcgggtgg tttaattaat aaatgtccac 47700



tgcttgtcat ttatcattag caaaacagga ggggttggag gtgggggcag ccaagagggc 47760



agggaagctt tctccaaaca aggtgcaccg ataaattaaa gctttatcca tcagtctcac 47820



aggctggctg ctgttgtaca gccccacgtt actttcctct ggttcagagg ccaatctcat 47880



gtttctgaag ggctttgcag cagctgtagg gggtttcatc tatgactgtg tttcccttgt 47940



caaatctcag caaaggactg tgttgcatgg tatggaggag agagagcagc atgtgcccag 48000



gggactggtt cccatcgggg tctcaaactg aaactctatg gtggatccag cctgaggcta 48060



gatttttgtt tggctacaat ggcatttgac aaattggaaa tttttacata aaaattcaag 48120



tttctggctt ctattgaaaa agcaaggcga ggcaaaacca aaccctcttt ttcagtatgg 48180



caacaagcag ctgatggcca gcttaggcag gcagggcagc catgtgaggt tgtgtgagtt 48240



gtgcactgca caaaagcacc tagcagaagg tgcaaatgga ggctgaatcc aggccaggct 48300



gtctttccag cagaagccct gtaggcagga tgcaggcctt ccacttcccc accaccgctg 48360



acaatccctg ctactttact cacctactcc attcatttac gttacctatc tgagcttggt 48420



aagcacttgg tgttttcatt cctagtatac aatcagggta ctatttcgtc ttctctatgt 48480



gagaaatgcc tcttcaacct tcaaggctca gctcaactca tagaagctcc ctggtggtac 48540



cctcctctgt attttctcaa cagcaaccca cactgctatt atagcactcg gcacaccctt 48600



gtgctctaat ttgttagcgg atcctgtttc ctgcagactt tgagcccctt gaagatagat 48660



cctaccattt ctacttttcc tctgcctggc acataatggg cactaaatca gtagggctga 48720



atgaatgggt ttatggccaa gtgtgcccca ggcaagggag gcctccaaga ggctgcctaa 48780



aatcctaagc caggaaggtc aggaaagggt gataaaaggt tttaactttg gggttttgaa 48840



agaccctaga ctcctaggtt tcttctcttg gacactctat ggggcactta aaatcctgag 48900



tcatgctgat tttgggattt cctctgacca gaaagctgag tgtttaagac ttttcacatt 48960



cgcttgtttt gttgcaagga gctagtaaga gctcagcctg gcctctccca aaaccactca 49020



taaaggagca gcagacatgg tgcagccaac agagacttca gggaacaagg atggctgtga 49080



cttgtgcaga gcaattctgg gatcctggaa cctgaaatac atctcctccc cagaaattta 49140



gcctgaaatt tctttaacca agatcaaaag gtgaaccttg cttctaataa tcagagagga 49200



ctgaatgtgt tctgcgaagg agagacacac tggtctaaat tatttccaac taacgtgtaa 49260



atgactgata gaggtttttg gtttttttgt tttgtttttg ttgatttttt tttttttcct 49320



aaatgctagt ttggtgagaa ggtaaaaaga gttataaaag tgcaacacca aggcgggtgg 49380



atcgcgaggt caggagttcg ataccagcct ggccaacatg gtgaaacctc atctctacta 49440



aaagtacaaa gaattagctg ggcgtggagg cgcgcccccg taatcccagc tcctcggagg 49500



ctgaggcagg agaatcgctt gaacccggga ggcggaggtt gcagcgagcc gagatcgcgc 49560



cattgcactc cagcctgggt gacagagcga gactccgtct caaaaaaaaa aaaaaaaaaa 49620



aaaaaaaaaa aagcaacaag ccctctcgct agtctctcct ttgtcgtcca gacccttcgc 49680



ggccgcgggc gttcgtggtt cgtccccttc cgccccctcc gtcccctccg ccctctccgc 49740



cgcgctgact cgccgcttcc tcctgggctc catcgcccca aacccgggac tgcacttccc 49800



ggcagacgcc gcggccaatg agggaggggc tgaggatttg gcggcggcgg cgctccgaga 49860



gtcggggtga cggggctttg tgcgctgagg cggaggctgc cagcacggag gcggaggccc 49920



aggggctgtg cacaggtcac cgcggagaga cgtgcgattt cccagccgag cgccgaggac 49980



cctgctgccc aggccaggct gccagccgta ggctcctctc tggcggcagc gggggcgcgg 50040



cgacacccgt ctctcggcct ccccttccca ccccacctcc ggagccttcc tcctgccgca 50100



gcacgcctgg cctggtccgg ctgtggccct cctcgatctc cgtgtccctc ctgtgatcgc 50160



attgagacgg ccgggcggtt agaacgggac aaactgaagg cccgatgaga gaaagggaaa 50220



gttaagaatg ctggagcaga acaatggatt tctctttctc tttcatgcaa gggatcacgg 50280



gaaacacagt tcaacaacca cctcaactca ctgactccgc cagcatccgt caggaggatg 50340



cctttgataa caaaagtgac attgctgaag atggtggcca gacaccatac gaagctacct 50400



tgcagcaaag ctttcaatac tcacctacaa cagatcttcc tccactcaca aatggctacc 50460



tgccatcaat cagcatgtat gaaattcaaa ccaaatacca gtcgcataat caatatccta 50520



atgggtcagc caatgacttt ggcgcagcta gaaactttag ccccactgac tattaccatt 50580



cagaaattct aaacagaaga ccacattaaa ttctagaaaa cccttcccct ccacagccac 50640



cacttcggta ccacaaactg tgattccaaa gaagagtggc tcacctgaag ttaaactaaa 50700



aataaccaaa actatccaga atggcaggga attgttcaag tcttcccttt gtggagacct 50760



tttaaatgaa gtacaggcaa gtgagcacac gaactcaaag catgaaagca gaaaagaaaa 50820



gaggaaaaaa cccaaaaagc atgactcatc aagatctgaa gagcgcaagt cacacaaaat 50880



ccccaaatta gaaccagagg aacaaaatag accaaatgag agggttcaca ccatatcaga 50940



aaaaccaagg gaagatccag tactaaaaga ggaagcccca gttcagccaa tactatcttc 51000



tgttccaaca acagaagtgt ccactggtgt taagtttcaa gttggtgatc ttgtgtggtc 51060



caaggtggga acctatccgt gctggccttg tatggattga agtgatcccc agctggaggt 51120



tcataccaaa attaacacag gaggtgcccg aaaatatcat gtccagtgtt ttagcaaaca 51180



gccagagagg gtgtgggttc atgaaaaatg ggtacaggag tataaaggtc ataagcggta 51240



tgaagaatta ctggctgagg caaccaaaca agccagcaat cactctgaga aacaaaagat 51300



ttggaaaccc tgacctcaga gagaacatgc tcaatgggat tttggcattg cccatgcaga 51360



gaaagcattg aaaatgactt gagaagaaag aatagaacag tatactttta tctatattga 51420



ttaacagcct gaagagggtt tatcccaagc aaaaaagaat gttggggccg ggcgcggtgg 51480



ctcacgtctg taatcccagc actttgggag gcccaggcgg gcggatcaca aggtcaggag 51540



attgagacca tcctggctaa cacggtgaaa ccccgtctct actaaaaaaa tacaaaaaaa 51600



ttagccgggc atggtggtgg gcgcctgtaa tcccaggtac tcgggaggct gaggcaggag 51660



aatggcatga accggagatc gcaccactgc attccagcct gggcgacaga gcgagactcc 51720



atctaaaaaa aaaaaaaaaa agaatgttgt ctccaaagcc gaagttaaaa aaacctgatg 51780



accaagatct gtgctttaaa ctcagccaga acagatcaat gcaggggagg tggcctcctc 51840



actctcaagt actgacattt ggagacacag cccgaggcag cacacaagcg cggacgagga 51900



agagccacct cctgttaaaa tagcctggaa aactgtggca gcaaggaaat cctaccagct 51960



tccattacaa tgcacaaagg gagcctggat ttgcagaagt gtaacatgtc tccagctgtg 52020



aaaattgaag aagtgtttgc tcttcagaat gctacagagg atgggaaatt aatttgttta 52080



ttcaacaaag ggaattggta acaaaacaga aataagtgtc agggggcaag acaggcttat 52140



aatttctaaa ccaaaccaga gaaatgaaaa gccaatgcag aatatatcat ctcttgaagc 52200



aacatctggt tctacaggct cagtagaaaa gaagcaacag agaagatcaa ttagaacttg 52260



ttctgaatca gagaagtcca ctgaggttgt gccaaagaag aagataaaaa aggagcaggt 52320



tgaaatagtt cctcaggcta cagtgaagac tggattacag aaagggtcgg cggactgggg 52380



agtgcagggc tctgtcagat tcagtgacag ctccatctcc acagcgattg aggaaactgt 52440



agactgagat tcctgtacaa tttcatccca gaaaatccag acttgtagtc tccatgcaag 52500



atttcttttt ctgtcggcag cttgataaac agtttatttg ttttagattt tgattttgcc 52560



agtcatcatt attggcattt tcctgcctgg tttcttcttg aagactctga acgattgctt 52620



taacattcaa atgatttttt tttttttcag tttgagctgg atgggtacag cttaaatcat 52680



gggtccagcc taaaaaccac catttaactt acactgatca gtttcaacac gacatggaat 52740



ggactgtttt tggttttttg tttttatttt ttatttattt gtggtgtttt tttgtttgag 52800



atggagtctc gctctgtcac ccaggctgga gtgcagtggc ccaatctcgg ctcactgcaa 52860



cctctgcctc ccgggttcaa gtgattctcc tgcctcagcc tcctgagtag ctggaattac 52920



aggcatgtgc cacgcccggc tgattttttt tttttttttt ttttgtattt ttagtacaga 52980



ctgggtttca ccatgttggt ctggatggtc ttgatctcct gaccttgtga tccgcccacc 53040



tcagcctccc aaagtgctgg gattacaggc ataagccacc gcgcctggcc aagttttttg 53100



tttttaaata aagcatcatt aatgcacctc tgacaaaaat aaataaataa ataaagcagc 53160



aaattctgaa agggagcccc gcaatgggga aagaggtgcc caaagggaag tgtggagttt 53220



aggaaagacc aaagttagct caggatttcc cctggagcct gggagcgggg gaattgtatt 53280



gagataaagg agcaccaggc ccatctgtct ggagctgaca cggagacctc tgagtaatga 53340



tttcaaggag gaagagcagg caagacccac tgagggtacc agaaacagca aaattgggtg 53400



ggtagataca ccgtctacct ggactggagt agaaaaaggg aggataaaga agacagtatt 53460



caccccacac acatttgctg tggacttact atgtgcaggg ggccatgccc agtactgagt 53520



tcagtctcct gttggaaaag tttcatcaga gcctgacgga gagcagattt ccacaagccc 53580



atcaataaca cttaatgtgc agtgcatttt gggctcaaac cctgaaggtg cctcgaaaag 53640



gcttgtaagc tgggggtaca gtcccctgcc tgaggaagga taccacaggc tgggcatagc 53700



tccattggcc cttctcaggg tggctttcca gaccccatta ttttaaattg caacgcctag 53760



cacttctgat cccttgtcct atttttctga gcatcactta cccctttctg acatatgttt 53820



tatttatcta tgtgtttatt gtctgttttc cccagtagaa tgcttctcca taagagcaag 53880



ggttcttttt tttttttttt tttcaaggca gagtcttgct ctgttgccca ggctggagtg 53940



aagtggtgcg atctcagctc actgccagct ccgcctccca ggttcagtgt cccgagtagc 54000



tgggactaca ggcgcccacc accacacccg gctaattttt tgttttcgtg tttttagtag 54060



agatgggttt tcaccatgtt agctaggatg gtctctatct cctgacctca tgatccgccc 54120



acctcggcct cccaaagtgc tgagaatact aggtgtgagc caccacgccc ggccaggttc 54180



ctctaaatca acttaattga gggatcattt acatataata aactgtatcc atttaccatt 54240



taaagtgtat aattctgaac tgtgggatgt atgcggatat atatacctgt acagccacca 54300



ccactaccac gatactgaac attttccact acccccaaag ttgcagtcat ccccatttct 54360



cccatttcct accccacact caccccaggc agccacggat ctgcttcttg tcaccatagg 54420



ctagaattaa cagcagggat ttttatctgt tttatttctc tgtccccaac acatcagatg 54480



atgcctggca tataattggc actcaataca tccttggtga aagactgaat taatggatgg 54540



gaaatcagat gattaagatc tgtcttcggg gccgggcgtg gtggctcacg cctataatcc 54600



cagcactttg ggaggccgag acagacagat cacctaaggt cgggagttca agaccagcct 54660



gaccaacaca gagaaacccc gtctctacta aaaatacaaa agtagccagg catggtggcg 54720



catgcctgta atcccagtta ctcgggaggc tgaggcagga gaatcgcttg aacccaagag 54780



gcagaggctg tggtgagcca agatcgtgcc attgcactcc agcctgggca acaagagcaa 54840



aattctgtct caaaaaaaaa aaaaagatct gtcttcgggc agctcagagc ccagtggaag 54900



agacaggtga aaacaatagt tacaacctcc acagatcctc tgcaggaagt gagagagtga 54960



ggatgcacat gatggaactg cagagtttga gttctttggc atcagaggga tttgagctga 55020



aggaccagct ccacttctca ctactttaca atctcacgtg agcccctaca ttcctctgag 55080



tctcttttct cttttgtaaa tcttgtataa gagcagtacc caccagagag tgctgttaaa 55140



ggatgtaatg ggataacgct tgccaaaggc atagcacagc acctggcaca caatccatgc 55200



tcaacaaacc ttacctactg atattcttgg ccattcgaag aacatggggc tgggcatggt 55260



ggctcatgcc tgtaatgcca gcactttggg aggccgaagc gggcagatct cctgaggtca 55320



ggagtttgag atagcctggc caacatggtg aaatcctatc tcttctaaaa atacaaaaat 55380



tagctaggcg tggtggcaag cacctgtaat cccagccatt tgggaggctg aggcaggaga 55440



atcgcttgaa ccagggaggc agagattgca gtgagcccag atcgcaccat tgcactccat 55500



cctggactac atgagcgaaa ctccatctca aaaaaaaaaa aaggaaaaaa aaaaaaagaa 55560



catggttgaa gaccagctct ataatatgag taagatcaga ctcttgattt tgtgaaggca 55620



aagccaggga agagaggcag aagctgaagt caagaccagc tagtttatgc tgcagtaaca 55680



aatgagtcca tggtcccagg ggcctcgagc actgaggtga agttcatttc tctcacactt 55740



atgtgtgccc tgctccactc ctatgccagg ctggcagtgt ggtttctggc tggggcactg 55800



ccatccttgt aacagaggga agagagaaca aggtgagcca tgcttggctt tgaaagtttc 55860



tgctccccag taactcacat gtcccacttc actggccagc accagtcatg tggcgaagcc 55920



tgagtgaggc caatggatca aggaagtgta atccttctcc agagaggaag aggaaatatt 55980



tgtgagcaat ggtacggtgt accacaggca tgcaagcaat taattacagg atgtgagaag 56040



taccatctac ctctgcacgg tgctaggaag gaaaaggggc tgactctgct tggaaggcag 56100



atgtcaagca gggaaagggg aagtctggga aggcttcatg gaagaggtga tgtgtatctg 56160



ggtcttaaag aaggaataag agctcactag gcagaaagaa acaagggaac atttaggcag 56220



gatgaaaagg caattgtcaa ggataaaatt gtgaaagtct gatgtgctct ccgtggttgg 56280



agcatctggg tacaggggct ggccctggac aggtggactg gactaagagc ggtctttgac 56340



catcacacta aggattccga cttttccgga agagtggtgg acaggcactg aggtttctga 56400



acgaggagat atgactttga gccctggagt ggctggatgg agggatgttt tcatcccaag 56460



tgctgaaaag aaaccaaata aaaggggacc ctaaatcagg ggaaaatccc tgggaagaga 56520



tgaagttttt ctgcacgaaa acccagatag gaacgagaac tcagatagga acggtcgccc 56580



gggggagctg ggccccttcc tgttgcagag agcaggcaca gctcggtggc aaacgccgat 56640



cagggcacgg cgaggccgag ccgagccccg cggacctgcc tgaccccgcg cccgcccccc 56700



gcgccgggag agaggcccct cctggcccct ggagacctgg cgtggcggat atttgtctgt 56760



gatacgattg taatttgggt cccttttggc cgcagtaaat tgtcctgttt gcacagcgcc 56820



aggctgaaat agcccggcgc gcgcgcccca ggaaatgagc tcagggccga cggccgcgga 56880



gagcgcgctg cagccgccct ggcgctccag gcgccccggc cagcccgcgt gggggcggag 56940



ctggtatttt ttcatttgac cgacttaaac aggtaattcg aattatgagc atgaaaaagt 57000



gcccaaggcg ctgtctgcca ccgaaagctc agagaaaagt gggagcgctg gcatggggac 57060



tggggaggct gcagcatctt tcttcaagcg cagcggtggg aggtaggggg aggaaccgag 57120



gctcggtctg agatgtgctg cctctgccac ctcccacgag gcaataagga aagtcaaaac 57180



ccctggtgac aaattgcgat tttacaaaaa tgatttcata ctagaaggac tccacagcta 57240



tggaaaagaa catttgaagc acagttacat ccgccttatc gtgccttaca ggtaacacta 57300



caactatcta cacatacatg gatttgtcag cattgccatt gatcacagca tatagacaat 57360



cctgtgctcc ttttttcact tgcttttatt ttctgaacac tctttcttgt tgctacacaa 57420



ttttcaattt accattttta ctggcagggt aacatttcat tggatggatg tatcataatt 57480



tataggacca tccctctatg ttggctgggg agggtgtctc cagtttttcc ctatcataaa 57540



taacacccca ataaatgtct ttgtagatac aaaatggttc tttcttcctt gtgaattatt 57600



ttcttaggat taattcccag gaggaagatt attgggccaa aggctatgaa catctttatg 57660



tcacttgata ttattgccaa attgctttcc aaaagggttg tctctgataa tttatggtgt 57720



aaaagaagga actaaccaaa tgtgtacacc gtcctttcct atacacacac aaagggcgtc 57780



accttggggc ccagaggaac aggtgcttgg ggtagctccg agtgggggcg ggataggggt 57840



gcaggggaaa ggccattcag aggtgcgggt gctgggatcc acctcaccct ggtgtcggta 57900



ctttctggaa ggacaggctt cccggatttt ttgactccct cccttgtcct cccttttgct 57960



tccatcagat gtttagacct atcactccca agcccctacc ttactgtccg cctctcagag 58020



tccttcctgc cagggctgcc tgggaactgg cccaccctag gccctgaaat agcatgattt 58080



gctgagccag cttttatact aaatgggaac tattggcacc tttggcttct tgtcatcttt 58140



atgttttccc gagaggtagc actaacccct cgatgaggct caggagggga agctggggtg 58200



tgcccccagg tgataccctg ggagaggctg tcttccttgc agctgctcct caagtcattg 58260



ccaggttcgg ctctggtgga aacttctgta tttacaaaga tcaagtctgg gagatgaggc 58320



caaagacaaa acatcttctg tccacactcc tcacactatt caatttgcgg atgttgttcc 58380



tcccacaatt gttttggtat caccccagct gacatcgtgg actttttttt tttttttttt 58440



ttttttttta ctttcctggc aacactgtag gaagaaagca cgttcagggg acaattcacc 58500



agagggaaaa cagacttgat ttctcctccg ctgtagcaac ccatgtgttc ttgggacaaa 58560



tctcttaggg aatatgggtc ccaactttac tgacaaaatg aggttctggc tggaccagcc 58620



acatcattgc tgtccctagg acccaaaagc ccttggtgga gtttcttttt ttttctttct 58680



ttcttttttt ttttttttga gaccaagtct ttcactgcca cccaggctgg agtgcaatgg 58740



cgcgatcttg gctcactgca tcctctgcct cccggttcaa gtgattctcc tgcctcagcc 58800



tcgtgagtag ctgggattac aggcacctgc caccatgccc ggctaatttt ttgcattttt 58860



aatagagacg ggatttcatt atgttggtca ggctggtctc aaactcctga ccttgtgatt 58920



caccagcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccat gcctggcccc 58980



aacttggtgg agtttcttat gctcccaagt tctcctccca tgactgcacc atggagatgt 59040



gggacagaag gtgcccttgg tgggagggac tctgaggggt agacagtaag gtgggggctg 59100



agctgggagt gacaggtctg agcatcagac aggagaagga cagggcagga tggggagtct 59160



gaaaactact gggacaaacc attacctgcc aaggagagac ctgacccaga cacacagggc 59220



tttccactgc ccctcaggcc tccacatatc tcctgtctcc agagatgcag cctgtttccc 59280



caggggctgc tgggaagccc cccactttat cactggaggg tgtcacactc agaatcacct 59340



ctccacccaa accgccaacc tcagtcccag gatcaggcct gtgcctctgg ctgtctcccc 59400



tcaggtgacg gtcacaccct gttgggtgcc ccgcctgcga ggacggagga gccatcactg 59460



ttccagctgc ctggagatct tggtgctggt gccagccctc agcctcaaga ggtctttcat 59520



ggtttcttcc ttgaagttcc tcacctccac gggcaaacag aagcccacat tcaagggaac 59580



tgcccagatg ggtaatgggt acatgccctt gggccccatt ggatgaaaat gaatgtagaa 59640



tgaggagcca agtcactcac tcttaggttg gtcttttctt gctttggcgc gtgtttccca 59700



caaacgctgc tgccatggtt tgaatgtttg tcctctccaa aaatcatgtt gaggtttagt 59760



tgccattgtg atggtattgg gaggtggacc ctgccctcac gatggatgaa tgactcatga 59820



tatgagtgag cttattatca tgggagtggg tttgcccttt cctgctccct ctctttccct 59880



ttctccctct ctttgccctt ccaccatgtg acaccctctg gcatgttatg atgcaacaag 59940



aaggccctca ccagatgccg gctccttgat tttggatttc ccatccttca gaaccatgag 60000



ccaaataaat ttctgtttgt tataaattac ccagtctgtg gtaatccatt acagcagcac 60060



aaaacagact aagacaattg cctactagca ggcatccctt tccaccaccc tactcagcca 60120



tttccaaccc cttcagctca atccctaatc tggaatattg tcccagtgcc tccagttcct 60180



acaacccaat tcgttttgta ctttgcgatg gcaccatcca atgagggctc aaagtcgtct 60240



tctctgggtg tctgcaaggt ccaactaaac cccactttat aatgtggtct tgtttatgat 60300



gtcatgcatg gtctgtctcc ccatagaccc cccggggcac tgcccacatc ttacacatca 60360



tttgaacacc gtggtactcc gcccagggcc tgcctgtcag cacatgctca gaaacatgtg 60420



ttgatccatt tccattgttc attcaaccct tcctgcacct gaataggctc ttggttgcaa 60480



gtgacagaaa caacactagc taagaagcag caaagcaatt aattggaggg atatttatga 60540



gcaaaaggag tccataggga gggagcacca ggatgggaat gggcaaggga ggccagggga 60600



caggaaacca gccagcttca agtctcatga acgtgggtta gggaggctgc ccagccctgc 60660



tcctactggc caccactacc acccctcgtg aagaccactg ctgagtgtga attctgggca 60720



agatggagga acatccgatt ggccaagcct gggtcacatg tctaacccca gatggaggtg 60780



ggaggatgtg gcctctccaa cttttgtggt ggggtccctg acttccccca ccaggcctag 60840



tcggtaaaag accccacacc cctaggccgg gcgtggtggc tcacgcctat aatctcagca 60900



ctttgggagg ccaaggcggg tggatcacct gaggtcagga gttcaagacc agcctgacca 60960



acatggtgaa atcctgtctc tactaaaaat acaaaacatt agccaggcat ggtggcacgt 61020



gcctgtaatc ccagctacta ctcgggaggc tgaggtagga gaatcacttg aacccaggca 61080



gcggaggctg cagtgagcca agatcgcacc attgcactcc agcctgggca acaagaatga 61140



aactccgtct caaaaaacaa aacaaaacaa aacaaaaaac ccacacccca atgtgggagg 61200



ctgagcagct ccccaaaaga caaatgtcta acagttactg agattgtgtt cactgtgtgc 61260



caggtgttac tctaggcact gacgtgtgaa gatgaggaag ccaggcccct gccaggcagc 61320



tggctgagaa agcaacccca gctccattca tcatttatgg ggcaccactc catgccaggt 61380



tcttgcccat gggctttctc agacatcatc ccatttaatc ctcactgtgg ctggggctga 61440



attaaagggg ctagtgaatg gtcaagggag cagcatggct gccaaggagt tagggcagca 61500



tcacagagaa gtgaccatct ggcagggact aaaatggact caaggaggtt gaaaaaagag 61560



aaaggccttc taggcagaag gaacagcatg tataaaggca cggaggcctg acaaagtcag 61620



agaggattca ggccatcatg gtttcttggt gtggctggac tatagggagc aaaagaggcc 61680



tagaggtggc tgttgcaggt agctcatgct agcaatgagc aggccttgaa taaaaacagc 61740



caatatttct caaacacttg gtaaatgcca agccctctat gaggcccttt acatccatca 61800



tctcccccat caggcaagca ctatttttat tctgaagatg aggaaactaa ggataagagg 61860



ggttaagtaa ctttttcaag gtcacacagc tagcaaattg gaagaggcag gatttgaacc 61920



aaagtttgtg tgttcaacca ctgatggtgc cagaaggaat aggaggagtc catgtaccta 61980



ccctgatcct ttaaaaaaaa aaattttttt tttttgagac aagatctcac tctgtcaccc 62040



aggctggagt gcagtggggt gatcacagct tactatagcc tcgaacacct ggatcaagtg 62100



atcccttcac ctcagcctcc tgagtagctg ggactacagc tgtgcaccac cacacccatc 62160



taatttgtta attgtttttt tttttttttg agacggagtc tcactctgtc tcccaggctg 62220



gagtgcagtg gcatgatctg ggctcactgc aacctctgcc tcctggattc aagtgattct 62280



cctgcctcag cctcccgagt agctggtatt acagccacca cacctggcta atttttgtat 62340



ttttagtaga gacggagttt caccacgttg gccaggctgg tctcaaactc ccgacctcag 62400



gtgatccgcc cacctcggcc tctcaaagta ctggggttac aggtgtgagc catcacgcct 62460



ggcctttttg ttaatttttt gtaaagacag ggtcttgata tgttgctcag gctggtctca 62520



aactgctggt ctcaaactcc tgggctcaag cgatcctccc acctcagcct cccgaaatgc 62580



tgagattaca ggcatgagct actgcacctg gccccttccc tgatccttcc catccccaga 62640



gactgtattt tgcaggattc cctattcccc tatctccatg gagagtggcc tccatagcct 62700



agggagtgtg gcttgtctta ccctcactct accaggtcac ttcaaggagg tcatggcaga 62760



gctagctcct ttgcaccatg acattaaaaa gtcagttccc tgttaccatt ctcagttttg 62820



tattcaggaa aaaggaactg gccaagctgc atagaacttt ttatggacag agagaattgt 62880



tgaaatgata aaatacagtc tgctgctttt ggctgggtca tttctaggca cttccactta 62940



gagggacagg tacagaaggc acccagcagg gcagcttcat gcttagggtt tggccctagg 63000



tcacctgggt ttggatccca gctgccccat ttcatagtca tgggactttc ggcatgttat 63060



ttaacctctc tgggactcag ttttcccatc cataaaacag agaataacca cagtgcctgc 63120



cctatagggc ttaggaggtt tagagatgtt tgtaaagtat ctggcatgta gtgagtacta 63180



aaaaaagaga aaaaaatgca atttgggcca ggcaccatta ttattctcca tccatcttca 63240



caataacccg tgtgtgaggc aggaggtgta cccatttgac aggtggggaa acagaggctc 63300



aaagatatta agtggccctc tcaagttcac tccctaagtg gaagagtggg aattcaatcc 63360



cagatgtgtc caattacaat gtccgtgagt tttacatggt ccctcgctgt ctcagggctt 63420



ctatgctggt gcacctcgcc aaaatgtcac ttgcggctga aaccacattg tcttccagat 63480



gatcagctat tgcaccagca acgcagggca ggagccaaga gcactgtgct gggggagcat 63540



ccaagccccc ccacgtgagc acgcccagcc caggcacttg tccctgctgt ctcaggtaaa 63600



actttggaaa cctcaacccc taattaccgc ctggcacagg gcacccggtg gtttccggat 63660



ggcttgtatt gactcgcgca gtcttcatag gacataggtc tgagctaaat ttaagccccg 63720



tcacagacaa tttaacagtt ttctgtgggg gggtaattga atggtaaacc ataattaccg 63780



atacaactga taccttaatt cccaaaacaa tctgtggagg tgtgtggaat tcaaatcagt 63840



ccaattagaa ttctatcttc tcataataaa atacagcata attgctaatt gccccctggc 63900



tcacaatatt ttaaggcaga aagttggttt tgttttttaa tatggctttt gtttttaatt 63960



ttgggctgtt gcacatgagt gggaaaggat ccaggtctct gtacttggga caagacgccc 64020



aggagaggcc agctatgcac agggctccac cgatgtcgga ggtctggctc ttggaaaggc 64080



caggatgagc tcttttgata gaagccacct gagctggaaa tgacctttgg gttgacaatg 64140



cattctgatg agcactgcag tcagaagttc taagtgagac tgtaggattt agggcaagtt 64200



tcttaacctg actcagtttc ctgatctgta caatgggtgt aataattgat cttcgtctgt 64260



gggttgttgg gaagactgac acagtgccca atatatggta aacactctag aaatggtagc 64320



tgctgttatt agtataaatt cactcactca ttgacccagc aaatacatac tgagtactat 64380



atgtgccagg cacaatttta ggtgctaagg acataacggc aaacaaaaca gatgaagccc 64440



ctgccgtttg tgcaacttct actggggaaa catgataata gacaaatgaa tacattaaag 64500



aatctggcct ctgcgagagg tcatgtgatg tggtcaagga ggatgtctct gaggaggtag 64560



cacctaggag cctgaattta ccaagaagga aactgagtct caaaagttca actttggagg 64620



accgggcatg gtgattcatg cctgtaatcc cagcgagctg ggagaccaag gcagacagat 64680



tgcttgagcc caggagttca agaccagggt gggcaacata gctagaccct gtctctgcaa 64740



aaaatttaaa aattagccag gcgtggtggt gcatgcctgt agtcccagct actcaggaag 64800



ctgaggtgag agggtcactt gagcccagga gttggaggct gcagtgagct atgatcacgc 64860



cactgcactc cagcctggat gacacagtga ggccctgtct ctaacaaaaa aaagttcaac 64920



tttgggcagc aggtgcacac cgcagatgtt tgggagagag gggcaggagg ataatcttca 64980



ggagagggaa ggaacaatct tagtggaaag gcactaggtg gtcaggcagc agctgccatg 65040



gagaagtcat gggttgctga actgttggaa tcccagctct ctagctttag tccgaaaggc 65100



tcctcatgat gacctgaagg tcgctgtgga ggagaaagtg cccaggcagt ggagctggag 65160



agacccagct tcagatcctg gccctgggtg acttgctgtg tggcctcaga cacctgctgc 65220



atctctccca ggctgcatct tctctcctgt aaactgggaa caagaagaca caggtcacag 65280



ggtcattggc aaggttgtgt gggaccatac ttgtcaagaa catggcacac attggcactc 65340



agcaagtgcc aagtctcctg aaactgaggc tgaaagaaag gaagtgactt gtccaagatc 65400



acacagtgag ttgtggcaga gaataggcaa gcttgggtcc agtgttctca ctcctgatag 65460



ccaagaacac agcttctccc gcggccagct agagggtctt tgcagggcaa ttgctgatag 65520



gcagcaggtc agaaaggatt tcagaggagg aaggattagg atcaagcaaa gagacacccc 65580



tatttggcat gcacctgagt tagtgcaaaa caagccattc agatttcaac ttccggcatt 65640



catttacttt caacagctaa gcatgttgga gatacctcct aggagctaca gagctgactt 65700



gcggggtaga gggaggctgg aggtatggga agggggctgt atggaaagga gacatatttc 65760



cccagcacaa ccccgtctgg cattcccaga cagccccgcc tctccccatt tgacaaatcc 65820



cacttcccgc ctgggatcca aggggtctcc aagattaaaa atctggtcac ccactggtta 65880



cagcgcaaat ggctcctatt acgagagggc tctaggggcc tgggaaccca gcaaggggtg 65940



ggcaggcgcc tgctgacaca gccttaccca ggggcaggcc cattcactgc ccacacagag 66000



gtgggaggtg ggggccctac ctggggtccc tgcacctcga cagtaattac tgctttctgg 66060



ctggccactg cccagaccac cttgttgatg ggaacttggt cccaggctga acagggcttg 66120



gccctactgc tcaagggccc ccccttccca cgactgaggc atgggggagg ggtgttggcg 66180



ggggagggtt cagactccca gcagcctaag gaagaagcag cgagattcag ggacagtgga 66240



cgtagaaact gggactgata gtctgggcag gctcttaggg tttaaatcac acttttagcc 66300



aagggacccc ccggtgcacc ctcagaagtc ttctggatat aacttcagac acctgggtcc 66360



cctaatgcat aactaccgtg acagcaggta taactggtat gtcaaacaag cataactcct 66420



aggatcatca atacacaact ttatttttgt ctcctacctt cctttagact ttctttagtg 66480



caagtaatct cccctgtttc tgaattggaa ctcccgcagg cccataactt ttctgcccaa 66540



tcctaggtag aatagagtcc tgaagttact ttaagtcaca agaaacatct cagttctgat 66600



gctagaatat ccagtccaag acagtgacca aaactgaacc tgatttagtg acaagctttc 66660



cccctcccgg gtgggcagcc tgcagtgaga gaggaggcca gtggcctttt cctcagtttc 66720



tcagcagtgc cgtacccagc ctggtcttca gctctctggg gtggagcctg gggagaaaga 66780



gggggaggcc agggcagtcc taccctggga aacaggcttt gggcctctgg ctggccttgg 66840



cctatgtcta acaccagctc tttaggcctt ggttaggaga aagtcaataa atttctgggt 66900



tttgtgcaat attcctgtag taagaatggt cccctagagt aacaatgact aaaacaagat 66960



aatatctaca ttcatactct aacacaattc tcacttattc tgcaaactct gattaaaggt 67020



ccatatgtga ttaacgctgg gatagccctg gagatgcaga aaacagcctc gttgggatgt 67080



ttgatgccct tggcttcatc acccatctca caatgaccag aaactcaatg acacccaggt 67140



gaggagaaac tcatttttat ccctgtttag tcaataacca ggaagcacgg ggcttacaat 67200



ctagagaaca cttctaaaga ctacatcttc agcagtaccc actttactga tggggaaata 67260



agcctcagag agattaacta atgtgcctaa tgatatttgg taactgacaa ggtttagact 67320



ctaaccaagg tcttctggtc ctaacttcag agtcctgtgc acttaagacc acaatctgac 67380



tctcttttgt tgtctgtgtg agagaagagt gaggcaggga tctgagtaca tgagaacgaa 67440



ccagggagga agggcaggca ggctaaactc tccccgggat cagcagaaag cggccaggac 67500



tcagacactc actgtggcca tggaagctgc aaggcagatt taaactccag acatttgaga 67560



caccatgtaa gccctccagt actgtaatat ttttggcgag aggaagatgc aaggaacact 67620



taagatttgg aattgttaac agcagtgaaa acactacttg aaagctgaag ggaatagcat 67680



gatgcctgct tgcagctccc agctcacatt catcccctca gccacccaac ataaggagtt 67740



tattttccca agagttcaaa caggagtccc agaacagatc ctcattggct caggcgggtc 67800



acatgtccct ccctaaacca atcactatag ctagaggatt tggagccctg attggtcagg 67860



cctgggtcat gtggttgatt tggagtacgc aaggtggagt tagctccccg gccctactta 67920



caatgtgggt agggaagagc tcttagcaga agggggaagg gggaacggga aatgggaaat 67980



tagataagaa agagggcttt gtaccacaga aggatttcta ctttatagat tggcagtagg 68040



agcccacaaa tgctttcaca tgggaaaaga cattttcaat gttgggggtc atgaaggtga 68100



ataaggcagc caagaaattg ttgctaccta atcattaggt gtcagttaaa catgcatagt 68160



atcggctggg cgtggtgcta taatcccagc acttttggag gccgaggcaa gtggattgtc 68220



tgagctcagg agttcgagac cagcctgggc aacatggcaa aagccggtct ctacaaaaaa 68280



tgcaaaaatt agttgggtgt ggtggcactg cctgtggtcc cagctactcg ggaggctgag 68340



gtggcaggat tgcttgagcc ccgagttgag gctgcagtga gctgagattg cacgacggca 68400



ctccagtctg agtgaaagaa tgaggaccgg gcgcggtggc tcacgcctgt aatcccagca 68460



ctttgggagg ccgaggtggg cggatcacga gttcgggaga tcgagaccat actggtaacg 68520



cggtgaaacc ccgactctac taaatataca aaaaattagc cgggcgtggt ggcaggtgcc 68580



tgtagtccca gctactcggg aggctgaggc aggagaatgg agtgaaccag ggaggcggag 68640



cttgcagtga gccaagatca cgccccactg gactccagcc tgggcgacag agcgagactc 68700



cgtctcaaaa aaaaaaaaaa aaaagaatga gaccccatct ctaaaaaaaa ataaaaaata 68760



aaataaacat gcatagtatc tattaatgta agttactcgg caatatggac aatgagtaag 68820



agggtaaaat ctggttctgt cacttaccag actttgaagg agttacttaa tttctctttg 68880



cctcagtttc ctcatctgca aaatgaggac agtaacaata actgctccta ggtttgttgt 68940



gcagattaaa caaatgtata caccgtaagg cacttcaaga aggggtagtc agagtgtttg 69000



cttcagttcc caggagctgg gagacctcac atcctggcgg agcctctagt tctggctgca 69060



cagacctgac tagcctggcc tggccgcagt agctggccct gagtagtgac ccgctcgccc 69120



gctgccctcg gaagcctcac ttggctgaca aacaggaagg tggcagggct gcctgcgtgc 69180



ccttgccgcc cccacagccc tgtgtctggc cccaaccctc atctctactc gcggctgcgg 69240



tgaacttgga tggtgctact ctcaccacaa accacagtcc gtcacaaatt gccgtgtggt 69300



gagtagcgag cacatttata attgatgaaa tcagggggtg agagctcatc gctgagatgc 69360



tcagtaaaca aagacctggt ccttgggtgg gggagggggt gcttgagagt aaacaagggg 69420



acaggaatgt tggggggctt aactctcctg gagagtacat gaaaggtctc acccaccagc 69480



ttttgttttt attattaagc ttattttaaa gagtttcaat cctatagaaa agttgcacga 69540



atatatagac tcacatagat tccttttttt ttagagaccg ggcctcagtc tgtctccctg 69600



gctggagtgc agtgctgcaa tcatagctca ctgcagcctc aaactcctga ggtcctctga 69660



tcatcccact tcagcctccc aagaagctgg aagtacaggc gtataccacc gtgcccacgt 69720



aatttttact tttttttttt tttgtagaga tggggtctca ctatgttgcc caggctggtc 69780



tcaaactcct ggcctcaagt gatcctccta tctcagcttc ccaaaatgtt gggatttaca 69840



ggtgtgagtc actgcacctg gcctaataat tatattcttc agtcttttct tactagtctg 69900



ttcttagtct cattctgttt aaccatttgt gagtaagctg cagagatcat gaacttccct 69960



gctaaatacc tcaaggacat tttcttacat acctataaga atgactaacg gccgggagcg 70020



gtgactcatg cctgtaatcc cagcactttg ggaggctgag gcgggcagat cacgaggtca 70080



agagatcgag accatcctgg ccaacatgtt gaaaccctgt ctctactaaa agtacaaaaa 70140



caagctgggt gtggtggcac ccgcctgtag tcccagctac tcaggaggcc gaagcagggg 70200



aatcgcttga acccgggtgg cagaggttgc agtgagccga gatcacacta ttgcactcca 70260



gcctggtgac agagcaaact ccgtcaaaaa aaaaaaaaaa aaagaatgac taatatcaga 70320



aaatgtaata acacaatact aatataaaat ccatgttcaa atctcaccaa ttatccaata 70380



caatcctttt tagcaactct tttttcccaa tcaaacctga ttagcctttc aatagtcaag 70440



gtcccaggta attgtcaccc ttggtccccc accccactgg gggctagaat cccacagtca 70500



ggtaggagtg atgaagctgt ggtcagatca gaaaacaagg ccaagcttag gataacagct 70560



ggagccagat gtagaatctg gctaagtaag ctctgggagc cctggaagct gtttccagaa 70620



ggtccccagg gatgggagcc caggtgagca gggagagagg catggaagct cttactggga 70680



tcccaaggga gacaggaggc tctcacactt ctgtcacagc agccaaaccc tgggcatgga 70740



caggtgggga caggagagat gttaggaaga tagggaggag atcatcaaca tttcaggcac 70800



agaagctggc agaagagaga cacctttgtc atctgtatta tgctaattgg ttagtctgta 70860



tatttattta acaaatgtct attgcaccct tactgtatgc caaaaactat tttaagtgct 70920



ggggatacag acccagttcc aaccttaagg tgtttatgtt ctattgggag atgggatagt 70980



ttgcactgtt gttgtgaaaa cggtcacccc cccatcccct cccactcccc ttcacaacag 71040



gtgtaagaga gtaaacttgc ccaatccact gctattacac ttggccatga gacttctttg 71100



gccactagaa tgttagcggt gtgtcatgat cacccttaac cgtgctgtga ggtttggctt 71160



ggcttttaag ttcctgccat tctccaagac aagcatgtgc cccagggagc tgctggtcca 71220



aggagaatgg agagagacat ggagtccacc caaacccaag ccatagcctg gagctgccct 71280



gctcgggctg acacacagac tcacaaatga gaaagatcag cacttgtttg gagcctctga 71340



gtatcggggt ggtttgttac acagcatcat ttcagcagta gctgactaag atgggtggag 71400



acagaatata aacaagccaa ctaagacatg tgtgatgtct tagtgataag aacaggaaga 71460



caaagaaagc aggagaagag gaaaagagtg gtcagggctg ttatagatag ggcagccagg 71520



ggaagccccc tgataaggga gcagagatct gaaggaagtg ggggaaggag ttatccaggg 71580



caggaatttc tcaaggagga aacagcaagc gcgaggctcc ccaggcaggc acaagctgag 71640



cccaggagca agcctgtatg gctggagcag aaggagccag cagggatagg gtggagtgat 71700



aggagatggt tcagagagga ggctggggcc agatccagtg gaaaggactt agacatttat 71760



tggacttgga catcatctcg tataacttgt tcctagctgt ctgatgaaag agcggacatg 71820



cagaaagggc gctggctgag ctccctggtt tgggatgagt actggcagtg ccaatgtcag 71880



ccacattcaa gccagtgttc caggggcctt ctctcagtct catgctcctg cttttccttg 71940



agattctccc ctctcttgtc ccctccctat cttggctctc tacccaccac cccaacacct 72000



ccagctcccc ctctgctccc ccttttgctc ccctggacct tcctggctct cggccttcaa 72060



ccctcagccc tcagcccctt tggctctcaa ggtggggacc actcccacct ctccagccct 72120



gtcttggagc cctgggcatt ctgtcactag ctctctgctt ggtcctgtcc ctcaggtggc 72180



ctgtggtcct ttcacactgg acatgcctca aacggagccc atcgcgaggg gaagggctct 72240



cagggactat ctgaaacctc gggagcttcg tagacccctc tacaaagggg agccagtggc 72300



ccagccagtg gctttatttt cctaagatac tgatttcaac atgtcactcc ccagccttct 72360



gtcttggatg gcagctcttc tctatgggat gaaggaaccc tcctcggccc agcactgaag 72420



gtcttctacc gtctggtctc agctcacctt tgcatcggct cccaccgcca gccaagctgg 72480



atgccctccc accccatgcc tcaagcacac cctgcttcta ggtccttact cacagggccc 72540



tttgctcagt gggagtttgc tgagggccca ctgtgtgcgg gcgctttcca gggtgctagg 72600



cacagaggag cagctggcag acttacattc gtagagcaca ctcgggtgcc tctgctgcgc 72660



ctccctgcac ctccccttcc ttcccttccc tcaaggctgg tcacctatgg cctccacgac 72720



caatgtctcc ctgctccttg gtcattggga aggtaagcat accttgcctt gtgtctgatt 72780



gttcttttaa atgaagattt ccatttttaa ctatagaagt gacacatcct cattgtgaaa 72840



aatatgtaga atgtggaaaa gaaagaagca aaagaagtta tataacctgg ctaagaacat 72900



ggagaagctt ctcttaaaaa gaggtgtcct cagctgctcg ccttccacac gccttcctca 72960



cagaggaggc agccttgatt cctgggtggg aaatgccaaa aatgacggaa tcaaagcctt 73020



ttctggaagc gggcagagat ttctaggggt ggggaagaga gaatatagaa cttaagagaa 73080



ctgagctctt gatggaaagt gggggtgggg aacacagagg ggaggcccag agactgagag 73140



gtctaggaga acgggttaaa accgaggcca gagccccgga aaaggagccc agaggcccca 73200



gctctttccc tacttactta ctgtatctgt gtgaccttaa gcgagtccct tggtctctct 73260



gagatgcagt attttcccaa gtgaacgggc attgccacac ttcacctcct cagggcgttg 73320



tggggacctt caaagccgta aagccctttg taaatggtaa cgcctaacac aaataggaga 73380



gcacgctgcc ctctctgggt aggcccctca tctgggtcct ggttccagtc tggtactgag 73440



cctctggagg acaagggtca catttattcc aatttctctt ctgcatgccc cagtgcccac 73500



tgagcacagt gggaatacaa acacatttat tatgcactct gcatatgact agaaggaact 73560



ttggagctca gatccaccct ttacacagat ggggaaaatc aaggctcaca ccacaaggtg 73620



agcttggtgg tatctttaca actccaggta gtgacaaaac caggatgcag attctgagga 73680



atgaacgagt gagagaatga agggaaatgg ggcaacagtc agcatgagca agggctgacc 73740



tatggtgggt cttagccttt actgtgctca gtggccccac agcaccatcg tctctccaag 73800



gagcacggaa gcagcccccc gtgtggggta tgggcacaga ccccagggcc caggcaggca 73860



ggggatgtgc cagtggtcct tgccacgggc caccagcttt gccaccctgc tccagggccc 73920



tggcctctcc ccagggtgca ggacgccact cccaggcact ctggctccgt ttcttaccag 73980



gctgctctgg gatggcagca tcccagcatc gctataaata gcatctctcc tgggccccag 74040



acggccagtt ggcaaacact ataatttgct gaaaagtttg gaatgtgtct aaaaatgaag 74100



aaggcaaatg agaccagcca tgagggggag caaccggcgt atccatttca gagaggggct 74160



gagcctcact cctgcttctt gccaacttct ttacaagggc actgcaggca aagcttcagg 74220



gagaggggac aaatatgagt ctaggaaaga actattgtca tttccagcat cagctgtggc 74280



ggctacctct tgtattggcc tcacccctga ccttcctgtc ctaaccaaag aacgagagga 74340



actgccactg cttaaccctt tgttgggctg tgctaatgaa attgaaggga acatggtgag 74400



catgcgagga ctgtgagagc cagaaagaaa cccccaaaat aatttcattc aatagtttca 74460



tccaaactct cccagtttgc aaatgaggaa gtgacttgac aaaggccggg caccaagttg 74520



aagcagaacc agattttggc caaggtccct gggctcccag ctgggtgctg ggcattggat 74580



cccaggcctg ctgtgagggc tggctctctt agggaaaggg gaagggtccc atggctctcc 74640



catcatgctg aaggttgaca cctgacaagt cactgcagct ttcccttgtt ctgctctgat 74700



tctcattcta ctctaaggag gcacagccac cattatcctg attttatggc tgaacaggcc 74760



gagcttcagg gtagaaactc atcctcatcc acaaagccat gggaaggctt gattagaatt 74820



taccactctg tccccagaca ctctgggctg ttcccacctt caggtagaac tcactgcctc 74880



aaaagccacc ttttactgtt ctttgtctta tcttctggga ttgtgatttt ccctgtagga 74940



aaaatcatgg acaatggcag tagactggcg tggtggctca cacctgtaat ctcagcactc 75000



tgggaggcca ggcaggttga gaccagcctg gccaacatgg tgaaaccctg tctctactca 75060



aaatataaaa attagctggg cgtggtggtg ggagcctgta gtcccagcta tcagggatgc 75120



tgaggcagga gaatcgcttg aacccgggag gtggaggttg cagtgagccg agattgtgcc 75180



actgcactcc agcctgggca acagagtgaa actccatctc aaaaaaaaat tctgaagtag 75240



agccccagat ccagcagtct cactgtatga tcttgggcaa gtcacttccc ttcactaagg 75300



ctgaatttat ccttatgtaa aactataata aaaataaaag cttcctttgg gaggccaaag 75360



cgggcagatc acgaggtcag gagtttgaga ccaccctggc caacatggtg aaacccagtc 75420



tctactaaaa atacaaaaac tagctggcca tggtgacagg cacctgtaat cccagctact 75480



cagaaggctg aggcaggaga attgtttgaa tccgggagat ggaggttgca gtgagccgag 75540



gtcgcaccat tgcactccag cctgggcaac agagcgagac tatgtctcaa aaataaataa 75600



ataaataaaa ataaataata aaataaatga atgaataaat taaagcttcc attcacaaag 75660



cacatggtca cgggctttat gtgcatttgt tctctttgtc ttcataacaa tcagacgggc 75720



aagatatatt cctatcctat tttacagatg aagaaattga ggcagggggt taagtgactt 75780



gtccgagatc acatcagatt ttcacaagtt ggaaactcac tgcaccagat gctctgaggt 75840



cctttacagc cttaataatt ctgccttttg tggttccaaa cacaatagaa attagcaatg 75900



gctcgcttgg tagttctcag ctcttgccag ctgagaggct tcatttgggg gcagaagaca 75960



gggagtaggg agagttcaca tctgtgaaaa gtctgtacag aggaggagcc aggatgcccg 76020



gtcttggcct gtcagccaag gccctctctc tctctctgca gaaggcacct gccgccctgt 76080



ggggccgctt agtgagaact gtggctgaaa agcgacatcg tgtgtccagt tgtagaactg 76140



cactgttaga gaactccagg acaatgagga gtggagggaa atattctgtt gttgtggact 76200



tgaaggcgct tttaaattat ttgtaaagtt ttaaaaacac acaggtgcca gaacctcaga 76260



cctagagaac cagcatctca agcagtagga cagagacctg tttttttaag acttgggcga 76320



ttctgtggca gcctagctga gaaccgcaag tatagacagc ttttaagggg gtgctggtat 76380



gctggtcaga acttctcagc tgcaacacct ccacctggtg ttgcacttct gtctgggata 76440



ccagaatgtt ctaggcagct gacagaaaca aatccattag acattattta taaaggaaaa 76500



tctagctgca ttgtacattt gatttgtgct ttgttaagaa ataaaatggc cgggtgcagt 76560



ggctcacgcc tgcaatccta acactctggg aaatgaaggc agaagaattg cttaaaccca 76620



ggagtttgag accagcctga acaacattgg gagaccctgt ctccacaaaa aaaataaaat 76680



aaaataaaat aaatagccgg gcacagtggc gtgccagcta ctggggacgc taaggtggga 76740



ggattgcttg agcccaggag gtcgaggctg cagtgagcca taattgcgcc actgcactcc 76800



agcctgggtg acagagtgag accctgtttc ttaaaaaaag aaagaaaaga aaaataaata 76860



aaatggcagc tggtaaaaaa aaatgagtat agaaatagat tcagttattt tagagaaatg 76920



tcagtgaaat tcagtccatg tatagaggat acagaaatct tttttatttt tttttcttta 76980



atgaagtggc tctcaactgg gagcaatgtc tggagacatt ttacggcttt cacaactgga 77040



gggtgctact ggcttctaga gggcaggggc aagggatgcg gcggagcatc ctgcaatcta 77100



caggacagcc ccccacaaca aagaattacc cggccccaaa tgtccatagt gctgaggccc 77160



caaggccctg cttccatgag cacaaaggac tcccattttt caggtcccct gagggtgggg 77220



gctctgccct cttcatcctc tctcccggga cctagcaaga ggcaggtgct cagtacatac 77280



tgcatgacag aagttcagtg aggggcattt tgagaaaaat tatctaatgt ggacacattt 77340



gcaaacctcc ctaatatgca cagtcctggg tgcatttcta catggcatag actgtctgaa 77400



gctaaaacat ctcatttgtc agctggacac tacccaagta caccaaacac aacctgggag 77460



tcaggggaga taggggtggt aaggaggatt cagaccccgt agaaacgggt taaacctcag 77520



ctccttcaag ctgtgtgtcc ttgggcaagt tgcataactt ctctgggcct tagtttcttc 77580



ctctgtaaaa tgaggctaac acaccttctc acaggctgtt gtgaaggtta aatggcattg 77640



tgcgcaaaaa atgatgagca tggccctgta tgtgctgatt aaatgttagc tatgtgggcc 77700



aggtgcggtg gctcacacct gtaatcccag cactttggga agctgaggca ggtggctcac 77760



aaggtcagga gttcaaggcc agcctggcca acatagtgaa acccccatct ctactaaaaa 77820



tacaattagc cgggcatggt ggcaggtgcc tgtaatccca gctacttagg aggctgaggc 77880



aggagaatcg cttgaaccca ggaggcagag gctgcagtga accaagatcg tgccactgca 77940



ctccagcctg ggcgacagag caagactccg tctcaaaaaa aaaaatgtta gctgtgattg 78000



gcaccctcat gactgaggtc tggattggtt gggtgtggct gctgtgctgc cagagacaag 78060



ctatcactca cattgtatct gaacaagagt aatgatggtg cataatgaat acattgggaa 78120



gaggcagaag gccttggact cactaactca aaacctccgt aggaggtgcc tgggaatatg 78180



catctgtaat aaactcccgg gcttttattt ttttgagatg gcgtttctct cttgttgccc 78240



aggctggagt gcgatggcgc aatctcagct cactgcaacc tccacctttg gggttcaagc 78300



aattctcctg cctcagcctc ccaagtagct gggattacag gattacaggc acctgccacc 78360



acgcccggct aattgtttgt atttttagta gagacagggt ttcaccatgt tggccaggct 78420



ggtctcaaac tcctgacctc aggtgatcca cccacctcag cctcccaaaa tgctaggatt 78480



acaggcccag gtgattctta cagttgggca aatttggaaa atctggcttt agtacaaaga 78540



ctttggagtt aagctgccag gctctgctac ttactaactg ggtgatctta ggcaagctac 78600



ttaacctctc tgtgcctcga tttccccacc tgttaagccc ttgcccagca ctactgctgg 78660



catccagtag actcaagaaa tggcagctcc tcccgcctct ttctcaagtt taatggtgta 78720



tgatcttcac cttcatcctc catacaaggc ctgccttctg ctcctgtcat ttctctctga 78780



ctcatccttt ctctaagtcc ccactggtcc ttggtgggtc tatttggtgc cccttggcct 78840



cctcatgggc ttctctaatt cttgtcccca ccatctcact gagtccatca agcagaagca 78900



aaaacagaac atgtgctgtg gtttgtagtt ttcaaggcat atttcacata ttttacctca 78960



ttgactcttc ccagatcatc ctgaagcatc gccgtcagga tctctgcaaa atgagtgagc 79020



tgagtctgaa gctcagggtg actgactgtc ctgagcccca gagcaagaaa acaggagcat 79080



ctctgcctcc cggccctgtg cattttctcc ggtgacctga ggcctctcag ttcctcccac 79140



tgcccctagt ctgattcgca tcctgccctt ctgctgctca ggaagcagct ctggctcccc 79200



agcgatcaga tccaagtgcc tacacctggt ttcaaggccc atcacaggcc acagcttgga 79260



atcattctcc ccctcctgga tttcctgcat ttcccagact ttccatcaac ccagctgggc 79320



tcctctctgc ctctcatcct ccctgcctcc ctgcttggat gcaagctgtc tccctgcaca 79380



gcacccctta tatagagtgg atagcacagg gaggaatgga ggcatgccat gcctggggtc 79440



cctccaaacc cccatgcctg gcatcactcc ctcagcccct gccaggtctc cttctccagg 79500



aagcctccct gcccttcagt gagtatccag tgctcagcca ggcggtcaca gccttttgct 79560



gctcctctcc tgccctgccc ccacccctca cacacacact ggcctttggt ccctttctgc 79620



ccagcaactc aatcttttgg tgttatttgt atttgtatta ccctatctgt cgaaaggggt 79680



cgggtggggt gggggagagg gctgccaccc cccatgtgga gcccaccgtg agaccatgaa 79740



cagaatgggg gtgactgaca gggctcctct gccaccttgg ctgctggggg cagtggtaga 79800



aatcaccact ggctattgtg acctccaaag gcacttgtca ctacacagtg acacaaaggt 79860



tggtttccgg ctcctccccg tggccagcat atccctggga tccaagacag gtccgcatca 79920



tactgccagg ggatcctcgg ggttaggcac ccaggaatgg atgggatgca ggcagggctg 79980



ggactggtgg ctggctctat tgtgctctga tgctgcagga acagaccaga tgtcatccag 80040



gggcccggaa tttggggggc gccgctgggt gtggcagcat cagaagcctc agatccgcat 80100



ctccatctgc cacaggtgag ctctatacct ctgagccagt ggcctgtggg agtgaaataa 80160



tcagagccac tttgaggtca gaaggtacaa caggggtgaa ggattggggt gggggagggg 80220



ttgggggtcc tggagggctg gtgctgtgtt tctgccttca ctcctgacat cctcttgcag 80280



tacagggtga atatttttac ccacatcttg caggtgagaa aatagaggcc tgagaggctg 80340



tgctgggagt tcacacaaga ttcttagtcc tggcaccaca agagtcacat gccaagtccc 80400



aggctgcatc caaaccaatt gaatcaaagc ctcaggggag cgggacccag gcaacagtat 80460



ttttatggtc cccatgtgat tgtggtaggg cagtcagtgg ggagaaggga gactaatggc 80520



tcagacggca ctttgcaaac tttcaagttg tgcaaagttc cctttgtgtc tttgtgtagc 80580



tcctaatcca cgctgagcct ccgtcctcat ctgtaaaatg gggataatac ggttccttga 80640



gttgatgagt tgaagtgctt tcttaattaa cattgcaact tgaccacccg gcactcttgg 80700



ttcccttttc cctgtgtgga gggtttgttt ctgttttgcc atagccctta ccacgtgtga 80760



acatatgata tattttacct attcaggatt ttcattcatc agtgcttgac actcccctac 80820



ctctgctaga acaccatatg catgaaggcc aagatcttca tcactgcttc acttttattc 80880



tttcctgtat cccaagcacc aagcagcaca gtgtttggca cacagtaaag tgcttaacaa 80940



atagctgttg aatgaatgaa tgtgcctgcc accatctcat acatgttaca ggcatcactg 81000



ctgctgctgg gcttgtggtc tggtctgcag ccttctcgcc tgaaccgctc acctcccaag 81060



ctgcttgcaa actgaataaa gctctcccaa agtcaagctg atcgctcctt tccctgagaa 81120



acatgcctct gtccctgctt cttggggtct ccccagccca ccatctcccc ttggacacag 81180



agtgccagag cactagcagg gagaagtggc aaagtttcaa gatttcattt gtaattcttt 81240



tcagatgaaa tgtcagaaat attagaaagg cagagtcata aatctgatcc taatatagca 81300



tagagcttat taatgaagaa taaatcacca agggaaacct ccccggggtg cttctccagg 81360



gcctgtgggg aagatggcat atttatgtgc aagcgtagcg ggtcttttac cttctcagat 81420



atatggccaa ggcagatttg tcagggcagt agccttaaca tcagccaatt atattttttt 81480



ctagtaaaaa ttaatctatt ctatagaagt ctcctaagca tttattggat taggatcaca 81540



tccaaatgta gaaaattaaa cacacacaca gtgcacacca cggcaggact ctgagaggcc 81600



ctgaaatgga atgacaacca cccccgccga cctctgctcc ctgccaagat attctcccaa 81660



ctgaaaaact cagagtgaag gagccagagg gaacagcctc attgcacagg tggagaaaca 81720



aaggcccaga gaggggatag gccttgccca gggtcaccca gattgctaag gctgacatga 81780



gacaggaacc ccaggtccgg gctgggtctg gtggcacaca cctgtaatcc cagcactttg 81840



ggaggctaag acgggaggat tgcttgagcc caggagtttg agtccagcct gggcagcatt 81900



aaaagacctc catgtgtaca aaatattaaa ataatacaaa aatcatctgg gcatggtggt 81960



gcacacctgt agtcccagct actcaggaag ctgaggtggg aggatcactt gagcccagga 82020



ggttgaggct gctgcagtga gtctcaatca caccactgca ctccagccta ggtgacagag 82080



accctgtctc aaaaaaatgt taaaaagaac cccagctcct tcttcccacc tcaaaagatg 82140



tccacatccc aatcccctaa ctgtcccaat gtgaatatgt taccttatgt ggcaaaggga 82200



accttccagg tgtgattaaa ttaaggatat gaggatggag ggatttatcc tggactatcc 82260



agatgggtcc aatatactca aaagcgttct tataaaggac agagggaggc aggagaggca 82320



gaggaggaga tgtgatggca gaagcagagg ctacaatgac acggggccat gagccaagga 82380



gtgcggcagg ctctagaggc tggaagaggc aaggaccaga ttctccctgg agcctgcaga 82440



agcactgcag cctgcgggca ccccgctttt caaacttctt ccctccacaa ctgtcatagt 82500



ccgtctgtgt tctctgaagc cacttggttt atggcagttt gttacagcag cactaggaaa 82560



ctcacatagt gttagaagga gaagcattgc cagggaaact gcacctggca gtgtaggctt 82620



ccctctgtac tcagtgctag ggaggtaccc ttaccctgag ggtcacccca gatcacccca 82680



gagtcatgtg gctcctcctc tccagaggcc acaaggccac caccccctgc ctgctcttcc 82740



ctcattcatg acgttctcac cctcacgtgc tgggctgcag cggggtctcc cactgttttc 82800



ttagtccccc agactcctgc agcttttctg cagcctgacc tccttccaga tggttttccc 82860



tagtacctca cctttcccca tccctcctct caaagacgct aaggaaagag cgacttgcac 82920



ccagggcttt ttcccgcagc ccctccctgg ttctcagcca ctgtcttcgg tcacctctca 82980



ctgcctccgg tcacctctca ctgcctcggg agcctcagaa caccagcctc cccttcccat 83040



ctccgctctg ggggcctgct ccagtctggt gattcctctc tccatctccc agcacttggg 83100



gacagttatg tcactcagag agctcccagg gaagaacctg aagaacagac ccagatagag 83160



gggagagagg gcagtggaac cttatggaaa aaggggcagg tagccagtgg ctgtggtgca 83220



aatgttctcg agtgtggccc ccggcctgcc tagcctggct gatgcttatt aaaagtgcat 83280



attcggccag gcacaatggc tcatgcctgt aatcctaaca ctttgggagg ccgaggtaag 83340



cggatcactt gcagtcggga gtttgtgatc agcctgacca acatggtgaa accccatctt 83400



tactaaaaat gcaaaaatta gccgggtgtt gtggcagaca cctgtaatcc tagctgcttg 83460



ggaggctgag gcaggagaat cgcttgaact cagaaggcag aggttgcagt gagctgagat 83520



cacaccactg cactccagcc tgggcaacag agtgagaccc cgtctgaaaa aaagaaaatg 83580



catattctgg ctggtgacga tggcacatac ctgtaatccc agcactttgg gaagctgagg 83640



caggaggatc acttgagccc aggaatttta gtccggcctg ggcaacatgt cgaaaccctg 83700



tctctacaaa aagcacaaaa attatctggg tgtggtagca cacacctgtg gtcccagcta 83760



ctcaagaggc tgaggtgaga ggattgcttg agtccaggag attgaggctg cagtgagctg 83820



taatcaggcc actgcactcc agcctgggca accaagcaag atcctgtctc aaaaaaaaaa 83880



aaaaaaaaaa aaaaggccgg gcacggtggc tcacgcctat aatcccagca ctttgggagg 83940



ccaaggcagg tggatcacga ggtcaggaaa tcaagaccat cctggctaac acggtgaaac 84000



cccatctcta ctaaaaatac aaaaaattag ccgggcgtgg tggcaagtgc ctgtagtccc 84060



agctacttgg gagcctgagg caggagaatg gcatgaacct gggaggcaga gcttgcagtg 84120



agccgagatc gtgccactgc actccagcct gggtgacaaa gcaagactct gtctcaaaaa 84180



aaaaaaaaaa ggtcaggctt ggtggctcat gcctgtaatc ctagcacttt gggaggccaa 84240



agcaggcggg gctgatcacc tgaggtcagg agttcaagac cagcctgacc aacacgaaga 84300



aaccccatct ctactaaaaa tacaaaatta gcctggtatg gtggcacatg cctgtaatcc 84360



cagctcctca ggaggctgag gcagaagaat cgcttggacc tgggaggggg aggttgcggt 84420



gagccgagat cgcaccatta tactccagcc tgggcaacaa gagcaaaact cggtctcaaa 84480



aaaaaaaaag tgcatattct agttgggcat agtggctcat ggctgtaatc ccaaaaattt 84540



gggaggccaa ggtgggagga tctcttgaga cctgaagtta aagatcagcc tgggcaacat 84600



cacaagaccc caactccaga aaaaatttaa aaattagcca gacatggtgg cgtgcacctg 84660



tagtcccagc tacttaggag gctgagatag gaggatcgct cgaacccaga agtttgagat 84720



tgcagtaagc tatgattgca ccactgcact ccagcctgga caacgagacc ctgtctctag 84780



aaaaaaaaaa aaaggcacgt attcctggac acccctctca ccaataaaca catccttgcc 84840



agagcagaat ctctgagagt gggcccagga gtcttcagtc taccatgctg ctgggatgtg 84900



tcttatacaa aaatcaggaa gtaggccgag cacagtggct cgtgcttgta atcccagcac 84960



tttgggaggc caaggcaagc ggatcacctg aggtcaggag ttcgagacca gcctggccaa 85020



cacggtgaaa ccctgtctct attaaaaaca caaaaaatta gccaggcatg gtagcgggcg 85080



cctgtagtcc cagctactcg agaggctgag gcaggagaat tgcttgaacc caggaggcag 85140



agactgcagt gagccaagtt tgtgccactg caccccagcc tagacaacag agtgaaactc 85200



cgtctcaaaa aaaaaaaaaa aaaaaaaaaa tcaggaagta gaaagagaat ggactttgaa 85260



gtcagggagc tctgggctga actcctagct ttccccacct cctagttgtg ggaatgctct 85320



ttatcttctc caaacctgtg ttctcttcca taaagctggg ggctctgatc tgcatgtggc 85380



gggaattatg aggattcaga taaacaggga aagcacagag gcagatgctg cggacgccct 85440



cccgcatctt ctgggggtcc cctcatcctg gagcccaacg gacctaactt ctgacagcct 85500



gagggcccct gggagtgctg aagaatgagt gtcccaccca ctccatccag cagccttaac 85560



aaaggacggg gatggagttg gtgtataagt acccgctccc tcatccttcc agtgggataa 85620



ctctgaggtg caggttccat gctggctcct gagtttccca gcaaaattaa gcttccgtca 85680



cccgccgggg tgcccttcct gacaacacgc ccctgtaagc tgccttcctt ccctgggtca 85740



cctccctacc ctcctactgg agcttcctgt gagcatccct caaacaaaca acttgccctc 85800



aagtacttgt ctcaggtcag ctcctgcggg accccaggct aacataagcc tggcagcctg 85860



gaaatgagcc ttttttttga gacagtgtct tgctctgtcg cccatgctgg agtgcggtgg 85920



cacaatcaca gctcactgta gcctcaacct cccgagctca agccatcttc ccacctcaac 85980



ctccagagta ccaccattcc tgggtaattg ttctctattt tttgtagaga cggggatttc 86040



gccatgttgc ccaggctggt ctcaaactcc tgggctcaag ggatccaccc gcctcggcct 86100



ctcaaagtgc tggaattaca ggcaggagcc accacgccta gccgtgagtt ctttttcctc 86160



tcctcgtctt tgactgtcag tgtggagacc aggttggccc agaccaagca aagccaccag 86220



agggcctgga tagtgctgtg gcttgcaggg atacatagac actgatgtcc gggacccagc 86280



aaggacagtg tcccctgact gtaaggatgc catcgaagtc ccaggaaagg cagctcaccc 86340



ttcccttccc cagatcccca gtatctgcta gtcaggaagc agagctatag gcccatccac 86400



aagaatcccc taatcccaca tccctcagtc tgaaattggc cctaaccaca actttcccta 86460



tcttcatctt tctttcctag ttcctcagac acaaagcaaa cagccacttc cccgctcctc 86520



agagacacct tgcctctaaa tcttgaaact gccaagcccc agctggctag gccactggcc 86580



acatgaattc tagtccccag gggcactgaa gtcacctccc agagaaatcc ctatgatttc 86640



atcttctatt taatctttat ttctcctcat acttttcaga acttcaaata atttctcgtt 86700



tgtagtaact aggaagccat aaatcgcccc tttatgtcta aggaaaatca attgttattt 86760



gacattttac cttaatattc ccgacttcct tcaactgtaa taaagcttcc atctgccttt 86820



tattttacag gcaattagta agtcaccttt ttaaaatttc tccacatttt ctatcaaatg 86880



aatgctagga ttgaaagggg agagctgttt tatgggattg aactcactga gtagaaggga 86940



tttatctgta gccttcgagg taccaacact cattaatggg ttttattgat ttgggggctt 87000



tttaaccctt agcaataata caggtgtcac ctgcccaagg cagttgggag ggggcaggga 87060



tgctgggagg ggctgtgagg gagtccacac atttctgagc cctgggccca agctagaaag 87120



gcagagaaat gagatctaac cctttgaagt gtgatcacgc tcagtgcaac cacaccctca 87180



gaggtaaatc atagcccaga caccctcttt ttcctggaga caaagttgga gttttttggg 87240



ttttttcttc aaattaccca ggggaatgca atgcttttgc acccctatca tgggatcaaa 87300



agaaagaggc ccattgttgg ggttcaaggc cctgggcttg gtctgcctct tttagccctg 87360



gggttgtggg caggccaggg aaggaacctc tgagactcag tttcctacga tgtgaagtgg 87420



agagaagaat ctcctcttta gccacctctc agggctgctg gtgttcgccc ccagaccacg 87480



tctgtgagaa atgcttagaa gactatgcag ggcgtaagaa actacataag gaaccaatga 87540



gaatcctagt cacaaatgga aacctcagtc cacaaactcc agaacgaaac cttccttgct 87600



tttctagaac tcatcttatg ggttctgtac cccccattgc ctgggctggt ggaactctgg 87660



tgccagtctt tccctagcaa tttctccaaa accccccacg gccttttcca ccattcccct 87720



tccttgaagg ccgccatttg acactcagag cccaggaagc ctttcttggt ccagacagca 87780



ggactggaag ccttagagct gtcggcaaga gatgtgagtc ctgtagctga ggacagtcca 87840



ggcagagtat gaataagacg gcaaaagtaa gtccagaaga cattaatggt agactttggg 87900



tggcaggtgt atgggtgctc actataaaat cttttcaaca ttgctataca cttgaaattt 87960



ttcattaaaa tgttagaagg gaaaaaaaag gcttattctg gggcaaatcc cccaaggtag 88020



ggtacccgcc tgtgatggga gaaaggaacg aatgtgagca gaggaggaag gcaaggggcc 88080



ctctgaatct agacgaattt gtttgtggga cctgctacgt tatttgtggg cccagtgcaa 88140



aatgaaaatt tggggccctt ccttcataaa ttaagaatat cagctaggca cggtggttca 88200



tgcctgtaat cccagcactt tgtggggccg aggtgggtgg atcacctgcg atcaggagtt 88260



cgagaccagc cagcctggcc aacatggtga aaccccgtct ctactaaaaa tacaaaaatt 88320



agctgagtgt ggtggtacat gcctgtaatc ccagctactc aaggagctga agcaggagaa 88380



ttgcttgaac ccaggaggca gagattgcag tgagctgaga tcacgccatt gtactttatc 88440



ttgggtgaca atagtgaaac tccatttcca aaaaaaaaag aaaaaaaaaa cagtatcaag 88500



atgggacagc aaagcattaa actacgtgcc tttcttatct tagagccctg ggtcctgcat 88560



ggttgcccgg ccatgaagcc agccctgtct gcttgggttg agaggtctat tttgaccaac 88620



cccttctgac ccatctctcc atttctaatc ttacaagaac aatacactga acctagcatt 88680



tgatgcaagt gaacaataag tgagtaggtt gggacctttt ctttttttct ttctttcttt 88740



cttttttttt ttttttttga gatggagtct cactctgttg cccaggctgg agtgcagtgg 88800



cgtgatctca gctcactgaa acctctgcct cccgggttca agcgatcctt ctgccttagc 88860



ctcctgagta gctgggacta caagcacgca ccactatacc ggctaatgtc ttttgtattt 88920



ttagtagaga tggggtttca ccatgttggc caggctggtc tctaactctt gacctcgtaa 88980



tctgcccacc tcagcctccc aaagtgctgg gattacaggt gtgagccacc acgcccagcc 89040



aacctttcta ataataataa tatttactgc tcacatggcc ttcaccgtat gccaggcact 89100



gattcagcac cccatggaca ttaactcatt caagcctccc agcaaccctg tgagacagga 89160



ctattgttac tcccatttca cagatgaaaa ctcagaggca cagagagaat aggtcacttg 89220



cctaagctct cagagctggt aagcggtaga gacgagcttt gctcccaggt agctgggctc 89280



cagaatcatg cttttaacca ctccactctg ccgcctctcc aaaaagatag tcaggacaag 89340



cctgacagag atggccccct ggatggaatt tttgctggtc ccaggagggc aaccttcttg 89400



gcatggctat agcgctcagt gcttctcaac tgcaaggtca ccacacacca tcttgaactg 89460



agtcacaggt gtcacattac tagtcagaaa gaagcaaagt ctgtgaataa ttaaactttt 89520



taaaaaatga aatcagattc aagcagtgtc ctctcacata tttgtatctt aactggcttt 89580



tcagactgca ggaacagcca gcaccagaga tatctcctgc aaggcctcct aggtgggttc 89640



ttggaagaaa ggaatgccaa tgaatatgat tgcaaggtga ggcagggcag gagacgcaag 89700



aactgcaccg ctaaccttat taatagggat tgaagagtgc tgaatttata aaaacaatgc 89760



ttttggtttc acaggctccc gctctcatta cacccgcccc aggacaccac ggacacctgg 89820



tagccaccag tggaattgca ggcttagtgt ccagaagggt ctttctcaca ttagctagag 89880



acgagagaag cggcgtcctc aactccaaga atcccgtatt ccccaaccca catccttcag 89940



tctgaaagtg cccctaacca ctactttccc taccacgtct ccctttccaa gttcctcaaa 90000



cgcaaagcaa acagccattt cctgcacctg tgtgcagtcg tagcagtacg taggagatcc 90060



aatatgcctg ggtgagtcag gagaactccc tgagatcatg gcccttgaga atgggtagga 90120



aatggccagg gagacaatag gggaagggca tcctcagaaa gaggggacag atttgggggc 90180



acgccttgta agaaagagct ccaggatgca cccgtgatta ttgtttcatt ttaccctcac 90240



aaacaacctt gccagggaga tagtattgct cacattttaa ggtgtggaag taaagattca 90300



ggaaaatgag cttacctgcc caaagtgatc tgacaggtaa gtggcagggc cgtcttgtct 90360



gatgtgagtt gaggaggatt tcagctggta gagttcggga gtaattctgg atcacctggg 90420



gaaaacaata aacatacagg gcggctttca agtgctcgca ctacccttgg caccgaagcc 90480



tgcccagtcc ttggggcaca gccaggagga tgagggccct tcctaccaag gtggctgcca 90540



ccgactggct gggctgcact gcatgcaggc cagagggccg gaaagatgag atttacgatg 90600



gccatggcct tcacgactta atggtcagga gttgagctat tttatcttat cagacagttt 90660



tgcctagaaa tagccacaga ccttcattcc aggatggctt ttagtcatga gggggtgacc 90720



tgcaggtctc ctaaatcatg ttaattccca gggcagcagg ctgtgctttc ttttctctgc 90780



agtgtctttc accattcccc agccatttgc ttctctgaag gaaagtctct ccggggccag 90840



caatgttgag gaatgcaggg tgtaggggag cagaaaggcc actctggtgt ggcctgactt 90900



gggaccatct gtccactcag acagagctca gcaaacggtc aaggagctga gaatcggctc 90960



agtccctccc tctccctctc actctcttct tccctctttc ccctccccac tctctcagcc 91020



cctcacctag ctagctgccc ctcccttacc tcgcaggacc ccctgggatg gaactgcttg 91080



ctgagcagtt ctgatgaagg caggaccctt tcctctctgt ggactcagtc cacagtgtct 91140



gtagacactg gccctccaga ggaccagtgt gtgagggggt gttgccagcc tctgtttctc 91200



ctgagccctc ctcccaagtg caagtatgag aactcctctc cacaccttcc tgcgtgtcca 91260



ggggcttcct ttagggttct aggagtccca agacatcatg ggtaggcagc agatggagaa 91320



agagcagaat gttccatcca ggccaggcac agtgactcac gtctgtaatc ccagcacttt 91380



gggaggccga ggcagcagat cacttgaggc cagaagttgg agaccagcct gatggagtag 91440



aaactccatc tctactaaaa atacaaaaat tagccagatg tggtggccca cgcctgtaat 91500



cccagctact tgggaggctg aggcaggaga attgcttgaa cccgggaggt ggaggctgca 91560



gcgactttga tattgcgcca ctgcactcca gctctggatg acagagcgag actccgtctc 91620



aaaaaaaaaa aaaaaaaaaa gaatgtccca tcatccaatg gcaggaccct gggcacacgc 91680



catgggacag tctcagtcat agccactggc tgggacaact ccagcaaaca gtgtcttcac 91740



tggtccttct caccatccac ccaccggctt ttcttgactc atggaggggt cttgcagacc 91800



ccttccccag atctgattcc taggtctggg atccccccag caccctcgct cactcttcat 91860



tcccctggag gtcccacccc acaccctctt gactctccaa ggagtgaaaa gctcctttca 91920



ctttcacctt gatattctgt taaaagccaa atccaaatcg ttagcaacag aagccagctg 91980



cccttctcta aaagccggag ggccggtcct caaacccctc ctggggggtg agatactttt 92040



gtatcctacc tggctggagt catgccttcc cctcaccctc aacccccaga ataggcaata 92100



aataaaatga aagttttcta atgcagtaaa taaaaggaag aaaactggag cagaccagat 92160



tctgttttat ttcctaataa aacagaggct gtctcctgac agtccccaga gggcccacca 92220



cctcatgatg tattagtaac acaccagctg ccttgcaaca agacttggtt atcatttacc 92280



tttataagga ggcttctcag atctcatctc accatgtgag ttgggcatta ttaataatcg 92340



ctaccattaa acatacctac aatgtgctgg gtgctttcta tacggtattc tatgcaatcc 92400



ttacaccgac cctgaagtgt aggcgctatt atttccactt cacaggtagt gctctgaggt 92460



tcattagctt tcttaaggtc atgcagctaa aaaaaaatga caaagtgaat ccaggtgggt 92520



cctcactcct gtggggcccc agggaacttc cggctgattt ctggggcgtt tgcgcgcaga 92580



gcgagacttg gccagcagag ggcgccagcg ccccgccaag gcagtgggag accggcggga 92640



aggcggctgt gaggcctggg ctagtttcgg cttagagact gcagcctcta gactcagcac 92700



gcagagctcg gaccagtggg acccaaggct tctctctcgg agactgccct ggagccaaag 92760



tctgtgggca gaggagggcc aaacactgcc tgggccttta ttttgcatcc agaaacaggg 92820



tgctctggat agcggcagcc cccacccgct gagcgagctc aggctggttg caaggagaga 92880



aaaaggaggt ggctgtcccc gtcctgcgac ctgggttctg gtcccagtgg gccgtgggaa 92940



agctgagact ttctccgtgc ctctgtttcc ccatctgtaa aatcgcagga tttgtgcgcc 93000



gcagactcca gagtccatgg tggggggcgg ggcgtggtcc tctcccattt cagaaaacct 93060



atcttaagag gcacatctag gaggctgcct agagtgacca aggtaccagg ggctgagcac 93120



cctgcagaca ttggtgatct ctggttgatc caaaacgaag aagcctccct gcgtgtcgat 93180



atgggaaaga gaattgatat gcaaatacat gcagcttctt tggtaaataa gaatatcaaa 93240



tcagagtcta tgagagttgg gggctggggt cggtggtcag agatgggatc cccaggcctg 93300



tagggccttt cttcctttcc agctctccaa gccctgccag tctttcctcc tcaaccttct 93360



ctcttgccta aagagaaatt gtcatgagcc tgctaatcgt gaaaggttct gtgccttccc 93420



tgctgccaaa cccatcaaac ctatttacca gaaatggctt tgttctaaga ggaacaaaat 93480



gaggctcaag ggtgagggtc cacaggtctg gcccccagat gcaccctgga gcaatgaggg 93540



cccccggggc agggactttt accagccttc cctggtggag gcaagattca cagtgcaaac 93600



tcttctccaa tgcagggaca gatgaccaaa ccttgcagac agcagcggga gctggaggga 93660



ctttgttgag gactgggacc caggtgtggt tgctgcaatg ccctctgctt tggcagagaa 93720



aagatgcaga ttcccaggtc acaccaagtg acctctccag aacctggaac agcctctgtg 93780



tggactgcca tgggagagct ggagccacca cagaatcttg ctcaccccag ggaggtggca 93840



gcaataggat catcatgact tttcaccttg acctttcacc acagcctgac ccctccaagg 93900



tgggagtgag cacaatggca caggggttgg gggtctgtgt ccgagtagga ggggtgttta 93960



aacgggaagt aagagagcat tgcagagaat gttaactgcc cctctcttct gtttgccaag 94020



cccatttggc ttcatgctgt ctccagcctc aggagtcagg aggctctgaa atgtctaaat 94080



gtcacatggc ttgaccacag ccagggaggg gcaaagccag gcattgaggt ttcttttctg 94140



attcccaaga agaaggaagg agggcgggag acaataattt aaaaaaaaaa aaaaaagaga 94200



gagagagcaa gacttgttag aggccacgag gagtctcagg ccagaggtgt ctctccccaa 94260



acccgggatg ggagggagct gggggccacc ctgccctcct gctctttctt ctgccctggg 94320



atttaattgc tctgcaagtt cagtgagctg ttcactgaca acactggggg ctctgggctg 94380



ctcagactca gacacaggtg tgccctcccc gctgaattta tgagacccca gacttagggg 94440



gcctcagggc agtaattcaa ggcaaatcct agagacctgt tgaacccatg gctactcagc 94500



agcagaattc cctaggaagc attagaaagc tacagactgc tccgggcttc tgcaggctca 94560



accctctgcc tcctgctacc tgcccctccc tgcctacagc agcccccctc agagcatttc 94620



tctcccccca tcactaactg cctgtctccc accaccccct ttaggaccgt ccctcctcca 94680



gcccatcctt ggagctgccc agttccctgt gaaatgctcc tccccacctc gccaccaaca 94740



tcagcccctc tgttgccctc tgtaccccat actgggcatt ctggctctca gcccttctaa 94800



cattctcttt ccttgctttc catcagaact ttccccttga gccaaactgc tttgttcctg 94860



ttctgcattg ccctggcttc tggatgcctt gtgcaccctt ttgctttgtt ctttcccagc 94920



cctacacagg cctgcatgcg cgcgcgtgca cacacacaca cacacacaca cacacacaca 94980



cacaccctgc ctactgctca cacactttcc tcctcctctg agtctcctga gccctctccc 95040



tttttcaagt ccctgctcca gccccaccct ccctgggcct gcccaggcca gccctgtccg 95100



ggagacctct cctctttgaa tggcagtgcc tgcgtcctca tctgttccac gccctcccca 95160



agttcattct cttcctccag agctagccag acctcccaaa gagccctggc aggagctccc 95220



aaagtaagag tttctttgat ctcctaggta gctgctcaat gccagtttgt ggatcgacat 95280



gtgattctta catttgcaac aacatcttct gtgagtagcc tgctccccca gcacgaggaa 95340



aatgagactg atcctgagag gatttgattc gtgcattctg gagggacaag cctgcctgga 95400



aaagtctcct gcaggagagg cagaccaggc tgccccaacc tgagtgtgga ctccagccct 95460



gggctgccgg gctatatgtc ctcccatgta cccactaccc tcacccagtc tcagcagcga 95520



ctcagaatct ctgtctgggt ctggtccacc accttcccct atctggactt gaactccttc 95580



agggctggca cagtgaccca tcatcctatc atgcccacag tgacctgctg ggtgctgtga 95640



gatgtcagtt tgggccctgc tgtgtgcacc aacttcactg gtgatactgt taccacctta 95700



agggtcagag aggtttaaga actcacccaa agtcacccag ccagtaaatg gctcagttgg 95760



ggttcaaacc caagtctata agatgccaga tcccctggtc catccagaca cctgactgca 95820



tctcgtacat tgcacacagt agatgtaaac aatacaaacg tctacagaag tcagggactg 95880



ggcgcggtgc ttcacacctg gaatcccagc atttcagagg ccaaggttgg tggatcgctt 95940



gagcctagga gtttgagacc agctgggcaa catggtgaga ccccgtctct acaaaaagta 96000



caaaaattag ccaggtgtga tggtgcacac ctgtggtccc tcatactggg aggctgaggt 96060



tggaggatca cttgaagttg aggtcaaggc tacagtgagc cgagattgca tcactgtact 96120



ccagcctgcg ggacagagcc agaccctgtc tcaaaaataa ataaataaat ctacagaagt 96180



gaatctgcct ggaaacggag aacctaaaag aatcatcagg aggtttggtt ggtgatgtag 96240



cattaaggtg cctgagagcc tcttacacac acaggccaag tggggatcta agccaaagca 96300



ccccctccat ggttttaggc ctatgctggt gaacaaggca gatgcagccc cgacagcacc 96360



tgccttccag ctctgccact ggacggagac atcacagact tgtagcaggg acagccatcc 96420



agcccactgg gtgttcacat atcttccact taaaacctag aaaatggaag cgcagagtag 96480



acataagcct ggtgctgttt taaaagggaa tggtttagta acctgtaggt agctctcttc 96540



ctatcccctg tgcctgcatg cagctgtggg accacagtgg cttgacacct ccatcagttc 96600



ccccattcta gggtcagaag tgggtcctat cagaaggtag agctttctgg cctgggcaca 96660



ttgcagaaag tgctgcggtt ctaattctca ccaccagaag gcgctcccag accctccgct 96720



gggttcatac tacaatgttt ccatctaaat ccatgaatca gttttttctc actcctctgt 96780



atgtgaaagc tacacctaaa atgtttctac ttaaatccat gaactagttt cccttacacc 96840



ttcctctgta ggtgaaagtt cctccagaga ctagagcagg actttgaagg cccatgaact 96900



gggaaattaa ctgtttaggt gccaaaagtg ggagttgtga tgggggttaa actgacagag 96960



gaggcgaatg ctattgctgt ttgaaaacgt aggccgggca ctgtggctca cgcctgtaat 97020



cccagcactt cgggaggcca aggcgggcgg atgacgattt gaggagatgg agaccatcct 97080



ggccaacatg gtgaaaccct ggctctacta aaaatacaaa aattagctgg acgtggtggt 97140



gcatgcctgt aatcctagct actcaggagg ctgagacagg agaatcactt gaaccgggga 97200



gtcagaggtt gcagtgagcc aggatcgcgc cactgcactc cagcctggtg acagagagag 97260



actccgtctc aaaaaaaaaa gaagaaaaag aaaagaaaat gtaaccacac attcagcttt 97320



caaaataccc gaaggctcgg ccgggtgcgg tggctcaagc ttgtaatccc agcactttgg 97380



gaggccaagg cggaaggatc atctgaggtc aggagttcaa ggccagcctg gccaacatgg 97440



tgaaaccctg tttccactaa aaatacaaaa attagtaggg tgtggtggcg ggcgcctgta 97500



gtcccaacca cttgggaggc tgaggcagga gaatcacttg aacccgggag gtggaggttg 97560



cagtgagctg agatcacgcc actgcactct agcctaggca acaagagtga aactccagct 97620



cagaagaaac caaaaataac caaaggctga ggacatcatt tcaatgtgtg tgtgtgtgtg 97680



tgtaacaaag accacagtgt gtagacattg ggtttcagag atcacctctg tgtccagctg 97740



tctgcgagtc tggactgatg agactctacc ctaccccact ggtgaatgtg gacctgcata 97800



tgtgtatggc agcgggagtg gaaacattgt cctgatgtgt ctcctagcgt gtctagctgt 97860



gtgtgtgttg ttaggaatgc tggatgtgga ttgagctttt gtggctgtgc tagtgtgtgt 97920



gtgtgtgtgt gtgtgtgtgt gtgcgcgcac acgcgcctgc ccctgctttg gcatttctgc 97980



ccagatccag gggctctgcc atatgggtga gcaggtacac acacgtgctt agtagtatct 98040



ctaagggtgt caaggacata cgtgtgtgct ggtgctctga gcctgcctgt attcaatttt 98100



gtgtgatgtg tggcccacat gcacctgctg tatataggga ctctcaggct ccagggagga 98160



gacatacatg tgtatgtgtg tgtttatggg tgtgcacccc tggtgtcctg cctctcctgg 98220



ggctcagtca aggccttctg ctctctgttt ctgggatgtt ttacttcccc atgacacaga 98280



gcccttctag gctgctgctc tcctctgtga gccttgcacc tgcctttctc cttcgccaag 98340



catgccttag gggagatggt ttatttcttc aattaaaaga agaaagaccc tgggaggctg 98400



cacacttaaa attaccacat tttaaaaagc tctgacagtc atgaaactat aaacctcaca 98460



gcagtgtctc tgctgccccc aggctactcc cagccctgaa ctaaggggtt cacctcctcc 98520



aggacttgga tggcccctct cctgaggctg gaagatcaca ccttctctga tcagagagac 98580



cccagtattg tttgcatgtg taatcatgtg ttcatctttc cgttcctcca gatctttttc 98640



ttccatagtg ttatattcag gaaagaggtt aggaagcaga aaacccaggt tctagcaccc 98700



tctccctggc tgggtgacct tggacgaggc tcctaacctc tctgggcctc agatttttcc 98760



atggcagaat gaagctggtg catatcatga tctaaagttt cttcctgctc tgacactgac 98820



atctgagccc cacaaaacct tgacagtgag tataggagtc tgcattaccc cattttaata 98880



aagaaacaga agctcattaa ggttaagtga cctccccctt ccagggacac tgcattttcc 98940



acaacagcac cctgaaattg acaaaggcgg agagagcagc aagaaacaga caggcacacg 99000



ttcacactcc ctgcatgatc ctctctgaaa acaccccgac agccaggagg ggattgatga 99060



gaatttgcgt cacagcccta cacagtaatt attggtgttc ataatgatgc cctaaggcat 99120



tacattcccc tgaaatgcct tcagaatcat caaagaaaga ttaagccatg cctactataa 99180



ttgctctttg aaataccttc tattttattc tcctgcttgg aaaattgata acctatggat 99240



tttcaattaa ctttaagtta caaagaatat tcagtttacc caagtatctc atccatttat 99300



ggttcccttt taggaggagt tgattatcca tctcaagctg tattccccaa ggagcctgac 99360



gtttttacga gatgactgag tttgggggtg gaaaaaccct tgatctgtaa ttggaggccc 99420



tggctgcagc cctttctagg actgtgactt tggcaggtca ccagcctctc caaacctcag 99480



tgttctcacc attaaaaaaa atggattaat gccagttctg ctccctcggt gtcattgcca 99540



gaatcaagta gatgatggat gtgtttgtaa atgtcatgtc tatgcaaatg agagatgctc 99600



aggaagcact tgagaactgc atggtgagac ctctggcata gccaagccag ccaaactgct 99660



aggctgggca aagaacacat aacaggcatc ctggcctcat ggcattccca ataacaactg 99720



ctgcagccat ggctaagtcc ctaggcctct ctgggcctca gcttcctgat ctgtaaaatg 99780



gggagcagag agagttggac aagatcagag attgcagatt ggtattccaa gaaccagtcg 99840



tgccatgttc tgggctgctt ttaattgaat ggcagtgttt tgaattcatt gccaacattt 99900



aaaagttgac aggttgccta taaaaaatct ggaaatatgg cttttttttg acaaatggaa 99960



agatatggtt ggttacactg ggcccatgtt catgcaaggg aaaattggcc agtgccaagt 100020



agctgttggc cccctctttc tcccatcaaa ggcacccagg tgtctccctc ccagctggct 100080



tggggaacct gtgtttactt gcctggctcc atgggttctg acccctaaac tgactgatct 100140



ctaaagcttt agaccttgaa ccatcatcac acctccccca ggtgtgctgg ccttcgtcgg 100200



gaggggaagg gtgaggtggg cagtgatctg ggaacttccg cagggccacc ttctccacct 100260



ggcctgggat ggggagaggc acattccttc agtagctccc aggccagtgg acagagggct 100320



ctgaagagac tccccccacc ccagccctca cagccagagc tagtaactca cagctgcggt 100380



tacccacacg ctgatttctg ttttaaaaaa tactgctggg taaacaggga gggaaacctg 100440



agctgttccc acaccacata aatccccggt ttgctgtcct atctggttag ctggtttccc 100500



caaataatgg cactgctgcc tcgaaagcaa ggggctggaa aagggaggcc ccgagaagtg 100560



ggcggctggg agtctcccag gctggctcca ggcccaggcc tggtggcctc cctccttctc 100620



tctttcagca cttcctgccc aggggcactc acctttgtcc tcactccttc cacctgagcc 100680



gcccttcctc cacccctctg ctttgtctct ctcaaaagac cntccacaga aggctttcct 100740



gggggaccct gggnccctcc ggcagccaga aagcccatag ccaaaggcag acctacccca 100800



acaccgcatt tccctctgga aggctccctt taaagtttcc ttccagagcc ttctgtcaaa 100860



gtgcaacgtc ctgactcaaa aggtaaggcc agagcctttt gcgtcctgaa aatgagttta 100920



gccttggatt aggattgcca gatttagggg gaaaagaaga cactcagtta aatttgagtt 100980



tcagataaac aaacaacaat tttttagtct atgtcccaat attttctgga acagacttac 101040



ctcagcattt tatctggcag cctaccttag ctcttttcct tgagaacagg ttctgatggg 101100



gaagaagaag aagataaaag agttattagg gccaccaagg tgcctatagg ctgaatctcc 101160



cagcctcccc agcagttcct cactgccaag tatatagttg cgggcaattg gtctgtagag 101220



taattgttga acaggaccct ccttaaaaca gggcagggag ggttgggcac aatggctcat 101280



gcctgtaatc ccaggacttt gggaggccaa ggcgggtgga tgatttgagg tcaggagttt 101340



gagatcagcc tggccaacat gacaaaaccc tgtctctact aaaaatacaa aaattagcca 101400



ggcgtgtagt cccagctact tgggaggctg aggcaggaga atcaattgaa cctgggaggt 101460



ggagattgca gtgagctgag atcacaccac tgcactccag cctgagggac tgagtgagag 101520



tctgtcttaa aaaaaaaaaa aaaaaatgta gagaggctgg gcactgtgtc tcactcctgt 101580



aaatcccagc actttgggaa gccaaggtgg gagaatcact caaggaagga gtttaagacc 101640



agcctgggca acatagcaag accctatgtc tatttttttt ttttttttga gacggagtct 101700



cgcctctgtc gcccaggctg gagtgtggtg gcacgatctc ggctcgctgc aagctccgcc 101760



tcccgggttc aagagattct cctgcctcag cctcctgagt ggttgggact acagccatgc 101820



gccaccacgc ccagctgatt tttatatttt tagtagagat ggattttcac cacgctgacc 101880



aggctggtct cgaacccctg acctcgtgat ccgcccacct cggactccca aagtgctagg 101940



attacgggcg tgagccaccg cgccaggccc ccatgtctat tttttttttt tttttttttt 102000



tgagatggag tctcgctctg tcgcctaggc ttggagtgca gtggcgcaat ctcgccttgc 102060



tgcaagctac gcctcccggn tcacgctatt ctcctgcctc agcctccaga gtagctgaga 102120



ctacaggcgc ctgccaccac catgcctgga gaattttttg tatttttagt ggagacgggg 102180



tttcaccgtg ttagccagga tggtctcgat ctcctgacct cgtgatccac ccgcctcggc 102240



ctcccaaagt gctggggtta caggcacgag ccaccgcacc cggcccccca tatctatttt 102300



ttaaacgggt tgtggggagg ggggcagtgg gcagagagat ggggagagtc catttgtcct 102360



tcctccttcg tgctgtgtgg aatgctgaca tgccagctga acaaggtgcc gcaggggggc 102420



aaagtagaga gacagtgcct gggggagagg ccatctcagc ttggactgtc acctccggcc 102480



ttttttatgg gggagaataa taaactctgt gtgtttcccc ttttgtcatt tgttttcatt 102540



ctatacagct gactccaata cagaacccct ggaaggtgtt catttgctgg gtgcttactg 102600



agtgtctgta cagtgagcca ccactttaca gttgaggaaa ctgactcata tgacttccaa 102660



gagccaggtt tctatgcagg ccattctgtg tgttacattt ttcagtcatc tgcctacaat 102720



tttggtagca gacaagtaga gcaccaaagg tttaaatgta tatatatgtg tgtatatata 102780



tatatgtgtg tgtgtatata tatatgtata cacacacaca cacacacaca cagagaaaac 102840



ccatctgcag aacttacctc ccttagctta gtgttttctg agatttagag aaagacctcg 102900



ttattgggcc cctggggtgg aatgcaagga ctatgttcta tagtttactc aactctgacc 102960



cttggatcat attatttgag cattacaaag ccctgtcagg gccaggcgcg gtggctcatg 103020



cctgtaattc cagcactttt ggaggctgag gcgggcagat cacctgaggt caggagttca 103080



agaccaccct agccaatata gtgaaacctc gtctctatta aaagtacaaa aaattggctg 103140



ggtgtggtgg cgcgtgccta tagtcccagc tacttgggag gctgaggcaa gagaatcact 103200



taaacttggg aggcagaggt tgcagtgagc cgagattgca ccactgcact ccagcctggt 103260



gacagagcga gactccatct caaaaataaa taaataaata aaaataaaaa taaaaaatat 103320



tagccgggca tggtagcatg cacctgtaat cccagctact caggtggctg aggcaggaga 103380



atcgcttgaa cccagtaggt ggaggttgca gtgagccaag atcacaccat tgcactccag 103440



cctgggcaac aagagtgaaa ctcatctcaa aaaaaaagaa aacaaaacaa aacaaaaaac 103500



cctgtgaggc aggctggcag gcagtagtaa ctctgctgcc tcaaagtgtt ctgagaagca 103560



aaggacacat gtgtacattc caaatacatc ccaggcccag tagtaaacac gctagcccac 103620



agccacgtat accatatcca aaatctgcct gtcttctgtc catcccttaa ggtcttacta 103680



gagaccaagc atctcatctg attcacacat tctactatgt aagcgcaggc taatggcttc 103740



atcttgtgcc ctgttcagtg gcatataaat atttcacagg gctctctgga gttgtctgta 103800



aggcaaaaat ctcaggtatc atcatcttca tcatccagat gttacccctg catgccaggc 103860



tatgacaaga gctttcatag accacctcac tcacgtctct cagcatcctc atgcggacgg 103920



aagaagttta tccccatttt acagatgagg aaactgaggc tcaagtgata aggcaagtcg 103980



ctcaaagcca tttagcttat taataacaga gctgaggtca ggcacagtgg ctcatgcccg 104040



taatcccagc actttgggag gccagggcgg gcagatcacc tgaggtgggg agttggaaac 104100



cagtctggcc aacatggcaa gaccccatct ctactaaaaa tacaaaaatt agctaggtat 104160



ggtgccagac acctgtaatc ccagctactc gggaggctga ggcaggagaa tcgcttgaac 104220



ctgggaggca gaggttgcgg tgagccgaga tcccaccact gcactccagc ctgggcaaca 104280



gagctaagac tccgtctcaa aacaaaaaac aaaaaaacag agctgaggtt tgaacccaca 104340



ggcccccaat tcccaaggcc atgatttgga cccttgtgtt atgttgccat agaaggtatc 104400



tgggggctgg gatgagccgt cttcacctac attgtgctgt gtcctgccca gtggttcagc 104460



atagttaagg acaagctatt cctcacatgc atcacccttt atagtcagcc agctctgttc 104520



tcagatgcag ttcatttatc ctcctaaccg ccaggtgagg ccggaactgt caactccatt 104580



ttgccagtga gaaaaatgaa gctcagagaa gggtgtgatt tgcctgagac cacacagccg 104640



gtaacaggca aggtcacacc ttgaacccgt gtcttctgcc tccaggtcca gggccttgcc 104700



ctgacaccct gcctctccaa gcacaagggg gtggggtggc cacaaacaga agcagccctg 104760



tcctgccaag tacacgcctg cctgccacgc acaatgggag acattccgca agttccacgt 104820



gatggctcag gtgtggccag gctgaaagcc tcctgggccc ccccacgccc ctgggggacc 104880



tcctcgtgac tcacactttt cctcttcctc cccttattct ccccaacaat cagaaaccgg 104940



ggtcccctcc cttcctgaaa acagagctct cctcatgagg ccacagggct ttttcgacac 105000



acagctcctt ccatccatct ctgtctctgg ccctgtgggg ccttgacagg gaaacgctga 105060



ctttgaggag gttaaaggtg ctggtgcccg gccttcatct aacaaatggg ttgccgtgag 105120



gggaggaact gttgttgttt tttcctggcc tcagaagagg ggcctgtcag gaagatgtag 105180



gggccagcag gcccccggcc gcgccccgca aggtggctga cagacgccag cagctgccgg 105240



gggctccggg gtgccagagg cctgtgttct cagggcaaag caccccaccg cgccccctcc 105300



ccatggccct cctgacctcc ccacccaccc caccatgacc cagggcccac cccgtccagg 105360



ggcaaagggc caggcgctgg gcctccctgc catgaggtcc ctgggccaga tgcagaggtg 105420



gagcaggaat ccggttacag cctgcggcca gcccagggga aggttttcct agggaagctg 105480



acaagccaga tcttcctccc agcctcccac ggattccttc cagaaccccc acagcacagc 105540



gtgcccccca caaaggacct cacaaggctg tttctgtaga atttcctcag aactccccat 105600



tcccaggttc accctttggg atcatcgagg ttaaccagaa atagatgtgc taggaaggga 105660



gccacatttg tccattactt actctgcctt ttgcataaag gatttctttc tttatttctt 105720



tttctttttc tttttttttt tttttgagac agtgtctcac tctgtcgccc aggccggagt 105780



gcagttgtac aatcttggct taccgcaacc tctctgcttc ccaggctcaa gcgattctcc 105840



tgccctcagc ctcccgagta gctgggatta caggcatgtg ccaccacacc cagctaattt 105900



ttgtatttct tttttttttt ttttttgaga tggagtctcg ctctgtcacc caggctggag 105960



tgcagtgacg tgatctcggt gcactgcaag ctctgcttcc cgggttcaca ccattctcct 106020



gcttcagcct cccaagtagc tgggactaca ggcgcccgcc accacgcccg cctttttttt 106080



tttttttttg tatttctagt agagacgggg tttcactgtg ttagccagga tggtctcgat 106140



ctcctgaccg catgatccac ccgcctcggc ctcccaaagt ggtgggatta caggcatgag 106200



ccaccgcgcc cggcctaatt tttgtatttc tattagagac ggggttttac catgttggcc 106260



gggctggtct tgaactcctg gcctcaaatg atctgcctgc ctcagccttc caaagtgctg 106320



ggattatagg tctgagccac cgtgcctggc ctacataaag gatttcattg aagatttgca 106380



aatgtctgtg ggctgggctg cctcaatttg aatcctgggt ccgctgcttc cctgctgtgt 106440



ggccttgtgc aggttacaca gtctatctgt gcatcagagt cttctgctga aaaacggagc 106500



tgataaaaag aaaagagaga gagagaaacg gagctgatga gaatgactgt tgcctcagaa 106560



ggcttttgtg ggaatccgtg ggggtaaaaa tgtgtaaggt gcaaagtgcc ttacacagat 106620



cccactctga ctgtcatctc agatgaggaa acagaagttc agagagatgg ccaggcatgg 106680



tggctcatgc ctgtaatccc agcactttgg gaggccgagg cgggcggatc acgaggtcag 106740



gagattgaga ccatcctggc taacacggtg aaaccccgtc tctactaaaa aatacaaaaa 106800



attagccggg cgtggtggcg ggtgcttgta gtcccagcta ctcgggaggc tgaggcaaga 106860



gaatggcgtg agcccgggag gcggagcttg cagtgagctg agatcatgcc actgcactcc 106920



agcctgggcg acagaacgag actccatctc aaaaagaaaa aaaaaaaaaa gaagttcaga 106980



gagataaggt gacttgttcc agggcacaca gccaggaagt ggcagacctg gggcttgaac 107040



tcagacccgt ctaacctcaa accccatgcc tcctcctctg catctggcct gctccaaact 107100



gaacagcagg acacctgagg ccaagtgctg attccaccat ttcttagctg tgtgagtctg 107160



ggcagcccag tcatccatct gagcctcggt tttgtcatct gcaaaatgga gacataattc 107220



ttacttaccc atcctaggaa agttgtgagg ctcagagaat tgtgtgtgcc acagctaagc 107280



cctgggcaaa gcagaaagat gagtctggtt gacagctatg accccatcca ctctactggt 107340



ctacaacact ctgaccgctt gttccagaag agggcacatc ttttcatatg tacacccctc 107400



cccatctttt acagctgctc ctgctcccag gatgtgtatc tgactggagt ttctggatta 107460



aaggccagtc gtggcttcat tccacatccc tgggtgccct tcggctcctc ctaggagcat 107520



ctcctgcacc caccccccag ggccccacct ccaggctgca gagctaagac ctaggggccc 107580



ctcctcaggg aaccctcgcc gtctttggaa gcagccagca gagacgctgc tgttaaggtc 107640



catgcctgtt tctgccccca tcctgctgct ctgggccatg ggaataacca gtggggaagg 107700



agttctggcc cctgggtgtt aggaatgtcg tcctccaaga aattgcatta accctctgag 107760



agaccagcag ggcgcagcca tgaggaagac tgattgggca tcaagatggc acttgggctg 107820



gctgccctgt gatgtgcacc agcccggaga cccacgtgcc tgcttgccaa agaggctcct 107880



ttggggaatg aggagcccct gattcctatt tccctacccc aaattcctcg gaagcctccg 107940



cctctggggg atgagaaagg gaagcaggtg ggtggaggtg aagggggcag ggagcaggtg 108000



ggaggagacc cgaagaaact tcaaggacct tatttaagag ccttgccatt gctgtgaaga 108060



aaaatgactt gaaacctctc tagagaagag tgtggctaat tggcatgtat gttggaggtt 108120



aaagagcgga aggaagaatc tgattgtttt tttaagttac tgagaaagtg agaatgtcac 108180



tctgggcaga gagaaattct ttttttctag agtgtgcctt tctttgtact gcagaccaca 108240



gtgggccgct gagacttgca aaaaagattt cttttaatcc accttccttt ttcgcaggca 108300



gcagtagaag ggcctttaaa tcaaatgcaa tcaccaagct tgtctcttgc tcttattcct 108360



cacttcactc cctggaattt ggcatttgat ggattctgga tctgacttaa ggctttttct 108420



aaatccaaga cttggggaat tttgttaaca gtgcaataaa aataacttca tagtgttaca 108480



ggaggcacat taaagacggt gtgtgtgtat gtgtgtgtgt gctgctctct ttccttaaaa 108540



aaaaaataca gacaatgttt ctttaaaagt ctccatctgc aaatcccatt agatgtgcat 108600



ataaggtttc tgatgattaa tagttgcctg ctagggtttt ggttggaggg gatcttgtgt 108660



gtgtgggtta acccctccct ctcctctctc acatttcact tcagaaattt gtcactctct 108720



ccccaccgca ggatttaaaa gtgtgtccca gcagccctgg tccagccctc tgcaggcatt 108780



tgctctgggc tccaggacga actcctcgtc agctggtgcg tctgggttgg gacagtgaaa 108840



atgtttagtg tcattggcga caaatacaca tacaggggat cccagtaggt aggctggtgc 108900



attggagggg caggagcaag cccgacatag gtgtgtgcac acacatagga gtagctggcc 108960



acatgtgtgt gtactttaag gagagacttt agttttgggt tttttttttt ttttggttcc 109020



tggggtaaat tttctgttga acatttttcc ctcctattta gttttttttc ttttgcattt 109080



ttaaaaattt gaacataaaa agtataaaga atcaaatctt tgaaaggacc gaggcgtgca 109140



gcggacagca gatggatccc gcggccagca gctgcatgag gagcctccag cccccagccc 109200



ctgtctgggg ctgccttcga aacccccact cggaaggcaa tggggcctca gggctacccc 109260



actacccgcc caccccgttc tccttccacc agaaaccaga cttcctggcg acagcgacgg 109320



cagcgtaccc tgacttctca gcctcctgcc tggcagccac cccacacagc ctgccccagg 109380



aggagcacat cttcactgag cagcaccccg ctttcccaca gtcccccaac tggcacttcc 109440



ctgtctcaga cgcccggcgc aggcccaact caggcccggc agggggttcc aaggaaatgg 109500



ggaccagcag cctgggcctg gtggacacca caggaggccc aggcgatgac tacggggtgc 109560



ttgggagcac tgccaatgag acagagaaga aatcatccag gcggagaaag gagagttcag 109620



gtaggtggct caggagcagc tgatcattcc tttactgtgt gaccctgggg aagttactca 109680



ccctctctgt gcctaggtgc tctgagcatg aatttctgtc tagtccatcc aaatgcagga 109740



gactggacca gttacctttg gggtttcttc cactgagagt tctaggattc tctggtgatg 109800



gggaccatgt ctgtgtccca gcactcctgg gccccaggaa gggtgtccag caagagaatg 109860



aaacaggatc agccaggatt tggaggacac gtgaaatgga tcctctgggt gcagactggc 109920



gagggctggt gaggggcttt cctgaatcag gctgccattg agtcatgctc ctccccacca 109980



tgctttggcc agccccaagt ggtcctagag ccacagggct cgcttaccag ggaagttcag 110040



ctgaggttaa ggctctgaga gctaagactg aagctgggac cctgggtggc cacccaaagc 110100



caagacccta tgtgtccagg agcctagagg cagagaagca ggcctgcggc tgggatggga 110160



gaatcaaggg gtgaggggga gatggagggc tgaggtttgg ggcagactgc ccaccagata 110220



tcaccctgcg gagctgggcc atgtccaggc caaggggaca gacaactcag catgctgaga 110280



tctggctgac cccccaggaa ggcagccccg caaggagctg caagggatgg gcagcctctg 110340



agagagtcag ggaggcaggc agccaaggga gtccgtgctg gagtcccaga ggctggagga 110400



tgagattggc ctatttgtta agattccagc taaagccctt ctcttcccca gggtggggac 110460



ctgctgcttc ctcacctccc caccaggccc tccctggttg ctcactatac ctgtccacct 110520



tttgtctggt tccttgtccc ggcctcgttc agaacaaagc agtgaccaag cctcctgccc 110580



gtgctgccct gttttcctcc tgacagccgc cctcaggggc acgcctgtct gtcggagcct 110640



gtagaggacc ttcccatggg gctaaccagg gcaggacaga aaagaaggac accaaccaac 110700



aggtgggaat gctttgtgct ttgctttata agcacagctt tcccgagttt ctgctcttag 110760



ccaagcccag gaatgctctg agatgaataa aggggtctca cccaagaaag ctcaaactga 110820



gaggaagaag aggcctgcag aggtgtgtca gcagtgggat gtgccctgat ggggaggctt 110880



aaggtgccat gggatactga cgtcagctct tttgagtccc acgggtttgg gagatgggga 110940



cagcaggttt tattagtacc ttgattctct caatctgcaa aatgaaagac tgaaagttgg 111000



tgagaacaca gaaagaatgg ggtcaaacta gagtgagcag ctcatctcca tttgcccagg 111060



acttttccag ttttagcact gaaaatcctg tcgtaggaaa ccccacagtc ccaggcaaac 111120



agaagaattg gtcaccctag aagtgagctc aaaccccagg cttcaggccc ccggtatcac 111180



ccccttcagt agatttcaaa tgcagtcctc attttgaaat gatgtttggt ctgtctgctt 111240



gaagaagccc cttcttcaat gggagatagg aactctagca gccctcatgg ctgctaaata 111300



gaagggccct ttaaaccgcc agccagttag atccccatcc cgaaaattaa ctcatcctgc 111360



ccctggtagg aaatgtgcta aggatgagaa gcaactctca gcgacttggc tctgaacctg 111420



gttgaagagc tttccccttg gtggcggcac gcagcactgt ggctccttcc tctctgccac 111480



tttccagaga actgacagcc aagggcattg ggaagggata gcaaagccaa gagcctgctg 111540



ggctcaggca gaatcttcca gcattccgag tctcagcaaa acccaaatgc accagctctc 111600



tttttggcga gtggccgatg gccctgcaat gcagagagac cattcacact aagcagctgg 111660



ccacccagga gtacagggac accctcggct gaacggcctg catgcttcag ggtcagactt 111720



tggtggaggg aggttcccat ccgcaggggc cctgggcttc cctaagggtc ccctcaggag 111780



caccagcagc agatgaggca gggcccagtg agctgactct cactcatccc cctgtgattc 111840



cagacaaact cactgttcag catggaaatc tttattgccg caatgcttgc atcctccttt 111900



ggaatttaac tgaaggggag gaaggaggca agaaagatca gctttgtaag agcccaaaga 111960



agggggaaag tgacgcaagg ctcatgacct actccaggaa tctggaattc agctcagaaa 112020



aggcaaaccc acagagagcc ccccacccaa ccctgccaat cctgagtcta taattggatc 112080



ccctctccaa aattgtgata ttttgttcat tatcaatttt ttgcattact tttgattttt 112140



acaaatattg ccttaaaata ttcttttttt tttttttttt gagatggagt ctcactctaa 112200



cgcccatgct ggagtgcagt ggcatagttt caattcactg caacctctgc cccttgggtt 112260



caagcaattc tcctgtctca gcctcctgag tagctgggat tataggcgca cgccccctct 112320



cccggctaat ttttgtattt ttagtagagt cggggtttta ctatgttggt caggatggtc 112380



tcaaactcct gacctcgtga tcagcccacc tcggcctccc aaagtgctgg catgcgccac 112440



cgtgcccggc cttccttaaa atattattga tcttgactac agaggggttg ggcatgccct 112500



tgcatttggg cctccccaag tccaggctga gtggtccctg gaaggttaac cagcattgat 112560



cagaaacgcg ttttccatag ttcttcccag ccagacagac aggctgcagt gtcagcacgg 112620



caacttttgg ctgcatgact ttggaaaagt tcataacttc ttccagcctt tgtttccctg 112680



gctgtaaaat gggcatatag cagtagcacc ttccatagag agtctctctg tgaaggttag 112740



atgcagtgat ccatgagatt aactctgtgc ctggcacata gtaagagttc aataaatagc 112800



agctgtaaat ggtattaggc ccatatttcc tgaaccagcc ttcagaatat aaggtctgac 112860



aaatatttct atatttatgg ggatggtgga attgaatatt tcaattatgc tgtctcagaa 112920



attcctgagt ctagggaact tctggcaatc attttgttcc agttgtcatc aggagcatgg 112980



agctcagaga cctgccggag aggttatggg gtgagttggg cctggcaaat gcaccccata 113040



ttgagtggct gagaagcctc cagaaatgga aagtttattg taagaggaat gttctctgcg 113100



cttccttcct cctttgccat ctccttcaac tgctccccgc tcactcccag tagaatctgg 113160



agctgatcta ctcaaagaaa ttatcaagaa agcaagggtt ggccgggcgc ggtggctcat 113220



gcctataatc ccagcacttt gggaggctga gccaggcgga tcacctgagg ccaggagttc 113280



aagactgacc tggccaacat ggtgaaaccc tatctctact aaaaatacaa aaaaaaaaaa 113340



aaaaattagc caggtgtggt ggcaggcacc tgtaaatccc agctacttgg gaagctgagg 113400



caggagaata gcttgaactt gggaggtgga gattgcagtg agcagagatc acgccactgc 113460



acttcattca gcctgggtga cagagcggga ctacatcaaa aaaaaaaaaa aaaaaagaaa 113520



gaaagaaaga aagagagaga gaaaggaaga aaggaaggaa ggaaggagac agagagaaaa 113580



agagagaaag aaaaagaaag aaagaaaaga aagaaagaag gaaggaagga aagaaagaaa 113640



gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gagaaagaaa gaaagaaaaa 113700



gaaagaaaga aaatgaacaa acggggagaa agaaagaaag cagggttcct ggcctttggc 113760



acttccccac cctggagacc agcatggtgt tatcttaccc aaaccactcc cagccccagg 113820



ccaatgggga ttaaagaccc ctgctggcag ggacagctgt gaggccactg ttgttttccc 113880



ccaaactgtc cttgctactg tggttgtctt taatttatgg gaatgaggga ttttgcggtg 113940



gtttcctcat ggggttcaag ggaaggttgc gtgtgattag agtggctaca ggtgaatccg 114000



atcgcccgcc tgggaaagcc atggtgctag aactcagcac tgctccctcc tgctctcacg 114060



tcctcactct gctgagacat gcctttaatc agacgtgatt tgtctcatcc ttcttcagct 114120



ccaacacgtg tgttcccaga gctgtcctgc cccaatttct ctttgcaaga cctgctctat 114180



gcctgcctcc gcccaaccac aaatttgcct aaggtataaa actccacaaa taggcctctc 114240



tcctcttttc cctcctgatg cccctttaca ggccacctcc ccgccccagg tcccctccac 114300



tacccctgcc acgaagccac acccagggac tgaccttgca aacacatcct gcattttctt 114360



ccccctctct gactgtgctc tggtggtttc tccttgccta gagcactctc cccttccccg 114420



tacttctgcc tgttgaagtc ctacttaaaa accacccagc tcaaaaacaa ccccttccaa 114480



gaatattttt gttcttcttt ttcaaaaatt tatagctaca tttgcatata acatagtatc 114540



aaagaaagct acagttaaga aatgtcgaag tctagtatct gctagaatct gtgttgattt 114600



tctcacttta gcttgcagtt gtttcataaa ggaactcttc tgaggtttct tacctgggac 114660



atcttatatt tgaaatctcc ttttttaaaa attggggtca aatacacata acataaaagt 114720



taccgtctta acagttttta agtgatacag tacagtagtt gtgcaatcga tttctagaac 114780



ttttaatctt gcaaaaccga aactctatct ccattaaaca acgacctttt ttcccttccc 114840



ccacccccta gcaatcacca ttctttctct tgctaaacat ttgactattt tagatacctt 114900



acataagtga aatcatgcaa tgtttgtcat ttttgtgact ggcttatgtc acttggcata 114960



atgtcctcaa gtttcaacca ggttgtagca agtgacagga ttttcttctt tttttttttt 115020



tttttttttt ttagaaagac agggtcttgc tatgctgccg aggcgggtgt tgaactcagg 115080



gcttctagca gtcctcccac cttggcctcc caaagtgctg gaattatagg tgtgagccac 115140



catgcctggc ctccttcttt ctgaagacaa taacattcca ttgtatggat ataccaaatt 115200



tctttcttct tttttttttt tttgagacgg agtctcactc tgttgccagg ctggagtgca 115260



gtggcgcgat ctcggctcac tgcaacctcc gcctcccgta ttcaagtgat tctcctgcct 115320



cagcctccca agtagctggg actacaggca cacgccacca cgcccggcta atttttgtat 115380



ttttaataga gacggggttt caccatgttg gccaggatag tctcaatttc ttgaccttgt 115440



gatctgcctg cctcagcctc ccaaagtgct gggactacag gcgtgagcca ctgtgcccgg 115500



ccaccaaatt tctttatcca ttcatctgtt gatgaacatg taggttgctt ccacctcttg 115560



gcagttgtga ataatgctgc aatgaacatg agtgtgcaaa tacctcctgg agagtgtatt 115620



ttctttttct ttttcttttt tgagacggag tctcactctg tcacccaggc tagagtgcag 115680



tggcgcgatc tcagctcact gcaagctccg cctcccgggt tcatgccatt ctcctacctc 115740



agcctcccga gtagctggga ctacaggcgc ccaccaccac gtctggctaa ttttttgtat 115800



ttttagtaga gacggggttt cactgtgtta gccaggatgg tctcaatctc ctgacctcgt 115860



gatccactgg cctcagcctc ccaaagcact gggattacag gtgtgagtca ctgcacccgg 115920



ctggagagtg tattttcaat tcttttgagt gtatacctag aagggaaatt gctatattat 115980



gtagtaatta tatttttaat tttccaaaaa aattatttat tattagaata aaatatagag 116040



acaggggtct cgctatgttg gccagattgg tcttgaactc ttggcctcaa acaatcctcc 116100



tgcctcggcc ttccaaagtg ctaggattac aggtgtgaac cactacacct gaccatattt 116160



ttaatttttc ctttttcttt ttttttgaga caagagtctt gctgttgctc tggctagagc 116220



acaatggcgt gatcacggct cactgcaatc tctgcctccc aggttcaagt gattctcttg 116280



cctcagtctc ccaagtagct gggattacag gcgtgtgcca ccacacctgg ctaatttttg 116340



catttttagt agacaggggt tttaccatgt tggccaggct ggtctcgaac tcctgacctc 116400



aggtgatccg cccgccttgg cctcccaaag tgctgggatt acaggcatga gcccctaatc 116460



tccccttctt ataagcatat caggcagatt ggattgggac ccaccctaac agcctcattt 116520



taacttaatc ccttctttaa aggccctatg tccaaataca gacacactct aaggtactgg 116580



ggttagggct tcaacatagg aattggggag ggaagcacaa ttctgccctt atagggactg 116640



tacaggactg tacggggaca ggaacaaggg acaaggttca aactgtggca cagacccttc 116700



agttgaaaac ccctttagtg aaagcagcac ccagatgtgt gcctgacccc agagctttcc 116760



tagctcaggg tcctgtcggc tggtagagct tttccactga gacaggaagt tgtttctagc 116820



cacaagcaga tccctgattt cctatcttac accaacaagt acagacataa aaagtggagg 116880



cagttggccg ggtgtggtgg ctcacgcctg taatcccagc actttgggag gccgaggtgg 116940



gcggatcatg agctcaagaa atcaaaacca tcctggccaa aatggtgaaa tcccatttct 117000



actaaaaata caaaaattag ctgggcgtgg tggcatgcgc ctacagtccc agctactcag 117060



gaggctgagg caggagaatc gcttgaacct gggaagtgga ggttgcagtg agctggatca 117120



caccattgca ctccagcctg ggtgacagag ccagactctg tctcaaaaaa aaaaaaaaaa 117180



agtggaggca gttttaggag tgaatctcta aagaagggag ctgtttgaca gaggaaagga 117240



gaaaagaggc atgggctgga tgcggtggct cacgcctgta atcccagcta tttgggaggc 117300



caaggtgggt ggatcacttg aggtcaggag tttgagacca gcctgaccaa catgatgaaa 117360



ccctgtctct actaaaaata caaaaattag ctgggcgtgt tggctcacac ctgtagtccc 117420



agctaatcag gaggctgagg caggaaaatc gcttgaacca gggaggtaga ggttgctgtg 117480



agccaagatc gtgccactgc actccagctg gggagacaga gtgagattcc gtctcaaaaa 117540



aaaaaaaaaa aggcaatggt aggctgggca cggtggctca cacctgtaat cccagcactt 117600



tgggaggctg aggctggtga atcacgatgt cagaagatcg agaccatcct ggctaacacg 117660



gtgaaatgcc atctctacta aaaatataaa aaaattagcc aagcgtggtg gcaggcgcca 117720



gtagtcccag nctacttggg aggctgaggc aggaaaatgg cgtgaacctg ggaggcacag 117780



cttgcagtga gccgagatca caccactgca ctccagcctg ggcgacagag tgagactccg 117840



tctcaaaaaa aaaaaaaaaa aaaaaaaagc aatagtagag atgagaatga aataaatgga 117900



caaccccaat aagtgtcacc tgggtcgcca gagtgatgcc aagtcccata caagtgacct 117960



catgcccatg ctcaccttct tgctgggcca cggtacagta ataggaggaa gggtggtcag 118020



agactaaggt caagcgaatt aacaaggtag ccctggttca ggtccctgat ccacaacttc 118080



ctggctgtgt ggacgtgggt gagtcctaac cctccctgag tctcttctga gaaatgaggg 118140



taacagtacc tacttcataa ggtgggtagc tgtgagacta aatgatatca gagatgtaga 118200



gtccacagcc aacacttggt aacccctggc tccagttttc ccaaacccac atatgagcac 118260



ccctctctct ttaaagtcct cccctgatgc tggctggctg catcaggttt cccacgttca 118320



aaaacaggcc aaagtgtcct gagctctgct gaagtctttg ccccctgctg tcagccgggc 118380



ctgcctgact ctgacgatgc tactggctta gggttgtggc agtgctgggt ggggtgtggt 118440



ttgaggggtg caccgctgca gcagctcctc ttgtcccgag tccatgtcca gaacccctag 118500



tgaggaagaa gttttatggt ccagagtggc cagcgtggga ggggagacag caactccaca 118560



ctcagccagt atccctctgg gcatccccgg cctcctgatt agagctcctg acctcctctt 118620



ctgacaagca aagaaagctc agagcccaaa gcaggaccca ggcctcggcc accatctgaa 118680



ctcagaggct ccagcacaaa tcccacgcct gggcctgctc aggcccctga tcaggtatag 118740



tcggaaactc tggagaaagt ccgtttctgc tgaggcagca ggatcctgac caacatcgaa 118800



gagggaaaga tccaatgagc ccgtgagctg taagaaggtc agcccagggg tcacctcagc 118860



tctgctccgc cactctccca tgctagggac tcaggattcc tgcccgctca cctatttctc 118920



tggcttgaat aaatcacggg cacttgggcc cagggagggg ggataactca gaggcagaga 118980



atcctttctg cctgagagac aggactcaca gcccctgcag acctccagag ctggcccttt 119040



tccccaactc cctctctgcc cataacttgg gcttctcacc caatttggct ccctggcctc 119100



tggccaggac ccaccccctt ccttttcttt tctttttttt tcccccttgt ttttcttgca 119160



tgcagaggta caggaacagc gtgagcagtg ggcctgggtc tcaagcccac acttcctttg 119220



gtgacagctg agggtgacat atggaactta taaacaaaac ccagaactac ccatgcctct 119280



ccccatcccc tcttgaaagc tgctgcgctt ccccctcacc aacccacccc gcctgggact 119340



ctcagcaaag actatagcac cagacttttt tttctgagac ggagtctcac tctgtcgccc 119400



aggctggagt gcagtggcac gatctaggct tcctgcaagc tcggcctccc agtttcatgc 119460



cattctcctg cctcagcctc ccgagtagct gggactacag gcacccgcca ccacacccgg 119520



ctaatttttt tgtattttta gtggagatgg ggtttcacca tattagccag gatggtctcg 119580



atctcctgat ctcgtgatcc acccgcctcg gcctcccaaa gtgctgggat tacaggtgtg 119640



agccaccgcg cccagccagc attacgcatt ttcattccag aagaacctgc ctctctccca 119700



tgaaatatcc cttgaattcc ctggccccag agaggctggg agccctgccg atgtctcttt 119760



aggcacctac aggagaggaa aagggcctgg acactggggt ggggcagggc tcagtgagac 119820



agtcaggcca accccaggaa gccagggaga tcctggatgt gaacatccaa ccagtctcgg 119880



gctggctcca tcccagtctt gtctatttcg acgggctttg acccctcctt ctgaggctga 119940



aagtaggaga gcttacgggg acatcaaagt gtctatgctg tgacagtgca ggaagccaca 120000



gacaccgttt tccgaggatt tgccaaggtt tcacctactg atgtcatgct ccaaatattc 120060



ccttcttttt ccctctctgg ggagtcccag ggagagagat ctgaacccag actcagacaa 120120



tgtccctaag ataggcacag cctccatact catcctcccc cgagggcagc gtgacatgag 120180



gctatagccc tagactggtc ccaggggcct tgggcaagtc atttagtctc tggatcttaa 120240



ttgctcatat gttcaacggg ctaatgtgta ccttacctac ctaatggaat aattaagagg 120300



ataaaatagg agacagccca atagggtgga aagagcttcc taacaagaaa atctgggttc 120360



taggcccaat tctgccccta acttgccgtg tgtccttaca ggagttcctt accttctcta 120420



agctcaccta taaaatgaaa aggtgacatt gatcatctct aagtccctcc cacctctact 120480



ttctatgatt ctgtagtatc tgtgaaagcc taaaagaagt tctctttgga ggaaagaaat 120540



cccttgtcaa ctgcacagtg ctatttgaat gtgaggcatt tggcatcctg tctgatttgg 120600



atattaattt atgtaaactg gtgccctcag agttggactg tagagtacag aactccagaa 120660



atgttcagac agggatgggt ctgtctgaac ctccctgtag ctctgataaa gctgtctgct 120720



cactttacga aggcctgcca aatgtggcag ctacatatga aataatttgc cctggatggt 120780



gtggaagctc atggtggaaa ccgcaatcac atgcacaccg tttgcatttc tctgggcatt 120840



tgactgttcc ctcacagccc tgctccagca gagggtgagg gctatgcagg ggctggggtg 120900



gggcaactcc ttcctaatca cagaggcagc ccactgaggg ccagcatcct ccctccgcag 120960



ttctggaaga ggcatctgcg gcccccaaga gagaagcagc gcaggagtga tgtggattgc 121020



catgtgacac atctagttgt tgtgcctgga attgtggaac tctgaaggct acagcaatag 121080



tggcctaggc caggtgcagt ggctcatgcc tgtaatctca gcactttggg aggccgaggc 121140



aggtggatca cctgaggtca ggagttcgag acgagcctgg ccaacgtgga gaaaccccat 121200



ctctactaaa aatacaaaaa ttagcctagt gtggcggcag gcacccataa tcccagctac 121260



tccagaggct gaggcaggag aatcgcttga acccaggagg cagaggttgc ggtgagccga 121320



gatcccgcca ttgcagtgac caatctccag cctgggtgac caaagtgaga ctcagcctca 121380



aaaaaaaaaa aaaaaaaaaa aaaaaagctg aaaggccaga catttaaaag ataacccttt 121440



cacacaggtc tggagatgtg gtgccttaag gagcatagtg ctctaactct gcccgtgagt 121500



catctcagat ataatctcca atagaactct ttctgatggt tcttgtgaac agagcttcag 121560



tgacatgcca ggcactgtgc taggtgttaa cgcccgctat ccagctcctg ttacttctca 121620



gcctgataag cacagcgggt gtagctattc ctgctttgca aatgaggaaa ttgaagctcc 121680



aagaacctaa aggacttgcc caagatccaa aagctcttcc tcggtgcctc actcacctat 121740



gagtgctaag gcccaggttc accaacaggt cctccgacac gtctgcatat ataacttccc 121800



tccacacagc tcaaggcagg gagagagaaa cggcccagca gagccctgat cattgagctg 121860



tgggaaggct ggggagggct ttggaacaga gcacacagca agacctcaga tctgactgaa 121920



gggaggaact aggagctgag acaagaatac gtgaagttgg aagagcctca gacttcatca 121980



aggctaaggg ttctcaatgg aagagagagt agggagtgta gggcatcaag gcttatgttc 122040



caggaaggaa ttctgacacc agctccctgg cagaaacaga atccggtcca atcccatact 122100



tctacacatg gggaaactga ggcccacaga ggagaggaag cctccctaac aaagttgtac 122160



tatcctggga acagaccatc ttgggaagca tgagttagtt tctttttctt ttcttttttt 122220



tttttttttt gagacagagt ctttctctgt tgcccaggct ggagtgcagt ggtactcgtg 122280



gctcactgca agctccgcct cccaggttca tgccattctc ctgcctcagc cttcccagta 122340



gctgggacta caggcgcccg ccaccacgcc tggctaattt tttgtatttt tagtagagac 122400



ggggtttcac catgttagcc aggatggtct cgatctcctg accttatgat ccgcccgcct 122460



cggcctccca aagtgctggg attacaggcc tgagccacct gcgccccacc cagcatgagt 122520



tactttcatg tggcagggtg cacaggaact gtgcccatga gcagggtgac tgaacagctc 122580



ccagaaacgg catgcaagtg ctcatagtgt ttccatcttg ctgaatatat tgcaatttgt 122640



aatactgttg cagaacaaag agagcgtaac ttccacttca actttcatag cttgcttccc 122700



atacttctgg tcccttcatc atttccaaca gtggtgaacg ttgatcccac tctgggaagt 122760



tgacaaggga caaccgccct cccagagcca atatccatcc cacccaccat tagtaggtat 122820



tgcccccagg ttcacacagg gagttagctg agaccgtcag ttcccaaccc agacttcttc 122880



ttcctgtttc ctctgctgga aatcggcact ggaaccccag aggctaaatc agggcaataa 122940



gagacaggag aggagaggtg gccagggatg gggcatagct tggctggcag tagtcagctg 123000



ccctatttgc agaactgggg tgggggaagt tatttggggg acatcatggg gcacctgtgc 123060



acacctaagc aggtcttgga ggagggtaga tgtgggtagc aaacagggtg gtgaccccag 123120



gacctctgga aggggtgaca agcccagctg ccatggtcca gctccaggcc ccaacctgag 123180



ccagccagcc aggagatatg gagagccttg gctctaatca gatggatctg ggttcaaatc 123240



tcccttctgt cacctaaaag ctgtcaggca cactgggcaa tttcctgggc ctgtctgagg 123300



ctggctcttc tgtataacag gattatttag caaatactta gcaagtactt tttcctcttc 123360



tctctaggag aattatgtgc agaactggtt gggggcgcgg taggggtcag ttgtgccagg 123420



tacagaagca actatggcta gatgctaggg tgagaaaaag tgtttccctg gggagacagc 123480



tattaatcaa attatcacac aaacccatgt taagagtgct aaagggggta agaacagtat 123540



ccactcatag gccgctgtgt ggtgaggtta aagccgcaga tgcctctggg cacacacaga 123600



aaccttcaag aagtgcatct gtttctatcc cagcccttca atggcatctc gtggagctga 123660



taaattggag aatatatttg tccagcactt ttagattttt cttttttttg agacggagtt 123720



ttgctctcgt tgcccaggct ggagagcaat ggcgcaatct cggctcaccg caacctccgc 123780



ctcccaggtt caaacgattc tcctgcctca gcctcccgag tagctgggat tacaggcatg 123840



agccaccacg cccagctaat tttttgttgt tgtttgtatt tttagtagag acggtgtttc 123900



tccatgttgg tcaggctggt cgcgaactcc cgatctcagg tgatccgccc gcctcagctt 123960



cccaaagtgc tgggattaca ggcgtgagcc accttgcctg gccactttta gattttaata 124020



gcatgttgca cacacatatt aactcgttcg gtcttccaat aaccctagga ggtaggtgaa 124080



atttcctcaa tttcttgatg aggagactga cgcccagaga ggctaagtga cttcctcaaa 124140



gtctccagca tggagattca ggattcaagc ctctgcggtc ctctgggcta tccactcccc 124200



gcaaccgtgg aaaggaaggg ctgggaaaca ctaagcctcg ggacgggaga agattgggaa 124260



accagtcccc gaccgcgccc gtcgtctaag cccgggtttc ctgcctctct ccgggcccgt 124320



gggccgggct gtgctccggg aagcccgtca tccgctcgtg accgaccctc cccggcccgc 124380



tgccaggagg gggcgcggcg ctggcggngg ccaaggccgg agggctcctc ggggaacccg 124440



gcccggggct gcgcgtcttt ccctgctgcc cacgctcccg cttccggagg ggtctggacc 124500



tgccttctcc ggcctggagc cagaggccgc cnggcaggca gcccgcgcca ggaactcggc 124560



cccctgccct gctccccggg cgcgncccgc gggcggccaa cccggatcgg acgcggaccc 124620



ccgggccagg gtgccacgac acccctgaac cgggcaccgg gactatcggg cccctccccc 124680



gccttctcga gttcccggaa cggtggcacc cactcccctt ccatcccccg gcggaggcca 124740



cggacgcgca gcgcgaggtg ggccaggcgc ccaaatcact ttaccgtgcg cctcctgcta 124800



gagagtcgcc cagcccaagg cagtggggcg cggaggcgga ggacggggaa actgaaatac 124860



aaagggattg agtggaaagc aatagagggg ggtgctggga ggggaaccag ctaggctcaa 124920



agctccaaag tggatcgccg ggttaatgtg gggtnntcct gcnnncntcg ccacccactc 124980



ccaatgcggc tgcttagccg actgcatagg cggcttctct gctttacact agggggtctg 125040



aattccccag cccagtcccc caggtagctt agacccggcc tctgaaaaca gaagatccct 125100



ccttccaaca ctcctcgccg gcaaggcaga gatgggtctt tcagggagca ggacgttggg 125160



ccgcaggttt cggtaaagca cctcactcgg agccacagcc tccatgtcta taaaatgagg 125220



aaaatggacc gggcgcagtg gctcacgcct gtaatcccag cactttggga ggccaaggcg 125280



ggcagatcac gaggtcagga gatcgagatc atcctggcta tcacagtgaa acgtcgtctc 125340



tactaaaaat acaaaaaaat ttgccgggcg tggtggcggg cgcctgtagt cccagctact 125400



cgggaggcgg aggcaggaga atggtgtgaa cccgggaggc ggagcttgca gtgagccgag 125460



atcgcaccac tgcactctag ccttggcgac agagcgagac tccatctcaa aaaaaaaaaa 125520



aaaaaaaaaa agataattaa tgaagcaaac gtcttttaaa tgttagagcc ccgggctcct 125580



gcagccattc cctggccacg tggcatgcat tgcgagttaa ttgtgtaagt gtgtggtctt 125640



cttcccacct cctctccacc caccacctcc attcattaaa gtgaaggtag agctgcctcc 125700



cacccgtctg ctcaagagat aaccattcag ccccttttat ttgttcagga ctttaccgtt 125760



tgtaagccct tcctaaattt ttttttcaag acgtagtctt gctctgtcgc ccaggctgga 125820



gtgcaatggc gtgatctccg ctcactgtag cctccgcctc ctgggttcaa gcgattctcc 125880



tgcctcagcc tcccaagtag ttgggattac aggggcgtgc caccgcgccc agctaatttt 125940



ttgtattttt agtagagacg ggggtttcgc catgttggcc aggctggtct cgagctcctg 126000



acctcgtgat ccgcccgcct tggcctccca aagtgctggg atgagccacc gcgcctggcc 126060



cctacatact tttcatttga acagtatgtg tgtgtcaaat cgcctgaatt taattcttgt 126120



ctcccacacc ccctggctga ataaacttgg gcaatttgct taacttctct gtgttcgttt 126180



tctggtccat aaagtgatac taatactaga accacttggt tgggctattg aggaataaga 126240



ggctaatata tgtcaggtac agcacctggc acagagtgtg tcccctgacc ctgttggcag 126300



ttatgactga gccccgctga atctaacatg cagcctgctt cagagggctc cagatggctt 126360



tccagacttg gccctctggg gcagattctg attccgtagg taggtctggg gcaggcctga 126420



gatccttcag gtctgaacag ctccctggtg ctactgatgc tgctggcacc caggcactcc 126480



tttgagtggt gaggtcttag agcagcggac ttgactgtgc accagacgca tctggagggt 126540



ttgtaaaaat agattgctga gtgccatccc cagagtttct gacttagtag gtctggaatg 126600



aggctaggat ttgcatttgt aacaagctct caggtaatgc tgatgctgct gatctgggga 126660



ccatagtttg aggctttgtt ttagagcatc tcacccctca agcttatggc caccagtaat 126720



gtcatgctgg ggggtgggct ggggagtaga ggtcattaaa cagccaagag tagcttctta 126780



tgctttggga ataaaagaaa gtttggggtg gggggagggt gggaggcagg tacctgagat 126840



tggaaaccaa aaataaaaaa tcttcccaat tctaatatgg gtaagacacc agaaggaata 126900



aaaaggacag tgtagctttt ttctcagcat cctgtaaaaa taagggagac tggtaaagac 126960



tgcctagttg ctcaagggca aaagaaaggg aatggagtct ccctcagccc atgtcttcct 127020



gtttggggtc ctctctcccc agacaaccag gagaacagag ggaagccgga gggcagcagc 127080



aaagcccgca aggagaggac ggccttcacc aaggagcagc tgcgagagct ggaggcagag 127140



tttgcccatc ataactacct gactcggctc cgcagatatg agattgcggt aaacctggac 127200



ctctctgagc gccaggtgcg cccccggtgg gcccctcctc ttctttgctc tctcatctcc 127260



ctcccttccc tcctttccca ccacccctcc ctggaccttc tcctttttct tcctccagcc 127320



agtccagcgg ttttcaactg tggccacacc tgagaatagc ctggggagtt ttgggttttt 127380



ttgttttttg ttttttgaga cggagtctcg ttctgtcgcc caggctggag tgcagtggcg 127440



cgatcttact gtaacctcca cctcctgggt tcaagcaatt ctcctgcctt agcctcccaa 127500



gtagctgggc tactggcgtg cgccaccacg cccggctaat ttttgttttt ttttttagta 127560



gaggcggggt ttcaccatgt tggccaggat ggtctcaaac tcctgacctc aggtgatccg 127620



cccgcctcgg cctcccaaag tgctgggatt acaggcgtga gccactgcgc ccggcccctg 127680



gggagatttt aatagtgctg atgtctgggc tccaccccta gggatgattt taattggcct 127740



aggatgggat acaggcctca gaatttttca aaggccccct aggtgattct cacatgcagc 127800



taggttggga cctacggtct ggctattccc aaatttgagt atatgttgga atcccccaag 127860



gcacttgttc aaaatgtgga ttctggaggt ccggagagag attttaccat aatgagtggg 127920



cctgagaatc tgtatttcta gtacattctc caggtgatct ggatatgcag ctggttcctg 127980



ggcacacttt gagaaaaact tccctggccc ttcgttttgg actttccctt cagccacccc 128040



acacccccac acccatgctc tgatacggaa taatagtaat aataaccgta atatttgata 128100



gcagatttca gttgacagag cactctgcca gagggctgga tattgaatca gaagacttag 128160



attcaaatcc tgcctctatc acttttccta gccctgggac ctctgggtct ccatctgtaa 128220



aatgggatca taatcctgca ggtaatactc aagctcagat gagaaaatgt gcttaccaga 128280



gctatctaaa ccaaaaagtg ctctataaat gtgcctaagg ataaggctga tgacctctgc 128340



tcccagaccc ttggggaatg gaggtagggg gcagggggac ctggcacagg cagggcaggg 128400



catgtgaagg gggtggggcc aatgcagagt gcttttagaa catgttcccc cgtctggggc 128460



tttatccgaa gccacaagac agacctctgg gcagattggt atgtcctctc ttcggtccta 128520



gttcctgggg cctttgaggg agtagggagt ggtaagtgat ggtttcaagc tggggtccct 128580



ggagttacac cctggctagc ctaagcattg acatggggag gaggtcacac cggccctgga 128640



gtgaccaggc tcctttgctt cctcccccag gtcaaagtgt ggttccagaa ccgaaggatg 128700



aagtggaagc gtgtgaaggg aggtcagccc atctccccca atgggcagga ccctgaggat 128760



ggggactcca cagcctctcc aagttcagag tgagattctg catggaggaa aaatgactaa 128820



ggactgagcc ccctacccaa ctacccccac cccaatccca ccttcaccct cttccttccc 128880



cagccagggc agcctctcca catctttccc tgactcttgg atatgaaact gcccagcatt 128940



cctgggagtc ttaggatttt ctaggaagtt ctgtccagcc tcttagcagc ctcttcccta 129000



gggcctttgc tcccacactc tcatggaatc agacagagat cctaccgggc cggatgaatc 129060



tggaaacagc ttcagagata ctgcttctca gcgtctcttg gctgccaccc atgcctcctc 129120



ctaccgctgt tctcctaggt cagccaggcc tcctcctggt ctggacacca cctggcctgg 129180



tgggagagga gctttggaac cagctggcga ctcggaaagt aaatgcttca aaaggaagga 129240



aatgacagag acacacgccc ttgcccacct tcctctgtag gctgcacatc tgaggctttg 129300



gggcccctta gttgtcccga aaccccaaga aaaatcagaa tgaggagagt caaggacagc 129360



aactcagctg ctgcaagcca gaaacacatc cctgtctcca aatttgttgg ctaagtggag 129420



acacttctga gaactgacta gagaagacag aaaaatagcc cgatgtaggt ttcggtgtcc 129480



ccatataggc ccgtccacac aggcttgact gggtggacaa gaatgaaccc atgacagcac 129540



ctgctgcttc aaaatcaaaa tcaatttagg gatacagcag gggctgttgg gctgtgctcc 129600



agagaaaagg agcagctact ccttttaaat ccacgatttc tggattgaaa acctgtccag 129660



atgctgagtt gttgggctga acaactagga gctgaaaaca acgtagaggc tggaaagtgt 129720



cccctgcatt ctggagggga ggggagataa taaggagggc tgctgggtga gggcctggag 129780



atgtggaacc ctggagtgga aggttctcca gtgacagtgt cctgtgactg caaaagggga 129840



caagaaaatc cctcttcctc catgggatgg atttaagctc ttgctgtgtg ttctacaaat 129900



gctgttattg tgggaggaaa tgctaggttt ttgtgtgtgg actgcccaga cctcagccag 129960



gtcttctgga gatgacattt gaggactgat ggccaaagag catgggggac tgaagccctg 130020



gctgcctcag cgctctgtct cccaacacca gctggtgttg cagagggagg tcaacgtgag 130080



tttggatctc ttgtacgcag atgtaatcat tcacatgtaa aaataacccc acctccccac 130140



cccaaaaagg gcaagagctg tggaaaatga ttgccaaatg agatggctgg ttagagcatg 130200



attttttcta aagcatactt catatatttt cttaagatta catcaagcta attgtgcgag 130260



ctcaattcac tttgtaagaa aactctcgga gaaataaaat caataaaaag caaagttccc 130320





<210> SEQ ID NO 2

<211> LENGTH: 18

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 2



ctttccacag gctcgtct 18





<210> SEQ ID NO 3

<211> LENGTH: 19

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 3



ctctcaaccg gaaatgtct 19





<210> SEQ ID NO 4

<211> LENGTH: 458

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 184

<223> OTHER INFORMATION: n = C or G



<400> SEQUENCE: 4



ctttccacag gctcgtctgt gtccctgcca ctctgagtta tccagaaacc accacctaca 60



aatgagggga ctcatctaga agacctctaa ggtccccttt tggctctgag gggtctctaa 120



taatccccac ttggaattca gcaccgcaag gaaattatgg gtatgtgagc cataatatga 180



tggncagcag gtggcgctgc cttccaccca tggtgatgga tggtttggaa agggaatgtt 240



ggtgcctttt gtgccacaag ttaagatgct actgttttaa aggaaaaaaa aaaaaaaaag 300



tactgatctt caatatgaag acatgagctt ttctcgcagg aaattttctt tttcacagaa 360



ctggtgtcag gaatcactga agggctaacc gtgatagtcc ttgcaagtaa gtcaaggttt 420



tatcctgatt ggaaatagaa gacatttccg gttgagag 458





<210> SEQ ID NO 5

<211> LENGTH: 24

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 5



gctcaaggaa cccaggcatc agaa 24





<210> SEQ ID NO 6

<211> LENGTH: 24

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 6



caagccagac agaagccccc tcag 24





<210> SEQ ID NO 7

<211> LENGTH: 297

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 143

<223> OTHER INFORMATION: n = C or T



<400> SEQUENCE: 7



gctcaaggaa cccaggcatc agaactgctc tctcccaagt ccattgcaag aaggcagtcg 60



tctggtcatg agagggttaa cagtccacat tccagagcaa gggaaaagga ggctggaggg 120



tcatagacaa ggggaggtgg tgnggagggc cagcttctca caacactacc ggctctgctg 180



ggagagatag atcaccccca acaatggcca cagctgtttt catctgccct gaaggaaact 240



gacttaggaa gcaggtatca gagagggccc ttcctgaggg ggcttctgtc tggcttg 297





<210> SEQ ID NO 8

<211> LENGTH: 18

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 8



agatcacccc caacaatg 18





<210> SEQ ID NO 9

<211> LENGTH: 18

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 9



aaggaaggcc agaggaat 18





<210> SEQ ID NO 10

<211> LENGTH: 356

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens



<400> SEQUENCE: 10



agatcacccc caacaatggc cacagctgtt ttcatctgcc ctgaaggaaa ctgacttagg 60



aagcaggtat cagagagggc ccttcctgag ggggcttctg tctggcttgt aaaactgtca 120



gagcagctgc attcatgtgt cggatgatgg atgatggaaa ggaggacagt cggctgcaga 180



tggacacagc gacttgcaag ttgaggcagg tggcaaagga cttgcagagg ctctgcaggt 240



ggggcatgct gattcattgc ccagttaaaa taccagagga tctgggcagc ctcttcacag 300



gagctgcttg tcctcaaaca atctgtcttc aatgaaagat tcctctggcc ttcctt 356





<210> SEQ ID NO 11

<211> LENGTH: 24

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 11



aggtggggct ataagcatcc atcc 24





<210> SEQ ID NO 12

<211> LENGTH: 24

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 12



gtcctttgcc acctgcctca actt 24





<210> SEQ ID NO 13

<211> LENGTH: 438

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 172

<223> OTHER INFORMATION: n = C or T



<400> SEQUENCE: 13



aggtggggct ataagcatcc atcctacctg ctcaaggaac ccaggcatca gaactgctct 60



ctcccaagtc cattgcaaga aggcagtcgt ctggtcatga gagggttaac agtccacatt 120



ccagagcaag ggaaaaggag gctggagggt catagacaag gggaggtggt gnggagggcc 180



agcttctcac aacactaccg gctctgctgg gagagataga tcacccccaa caatggccac 240



agctgttttc atctgccctg aaggaaactg acttaggaag caggtatcag agagggccct 300



tcctgagggg gcttctgtct ggcttgtaaa actgtcagag cagctgcatt catgtgtcgg 360



atgatggatg atggaaagga ggacagtcgg ctgcagatgg acacagcgac ttgcaagttg 420



aggcaggtgg caaaggac 438





<210> SEQ ID NO 14

<211> LENGTH: 17

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 14



cctaaggtgg gatggtc 17





<210> SEQ ID NO 15

<211> LENGTH: 18

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 15



ctcagggatg gaagatgt 18





<210> SEQ ID NO 16

<211> LENGTH: 310

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 98

<223> OTHER INFORMATION: n = C or G



<400> SEQUENCE: 16



cctaaggtgg gatggtcaac tggaaagctt taaattaagt ccagcctacc ttgggggaac 60



ccacccccac aaagaaagct gaggtccctc ctgatgantt gtcagtttaa ctaccaataa 120



cccacttgaa ttaatcatca tcatcaagtc tttgataggt gtgagtgggt atcagtggcc 180



ggtcccttcc tggggctcca gcccccgagg aggcctcagt gagcccctgc agaaaatcca 240



tgcatcatga gtgtctcagg gcccagaata tgagagcagg taggaaacag agacatcttc 300



catccctgag 310





<210> SEQ ID NO 17

<211> LENGTH: 18

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 17



cccctgcaga aaatccat 18





<210> SEQ ID NO 18

<211> LENGTH: 21

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 18



gaaaccccgt ctctatcaaa a 21





<210> SEQ ID NO 19

<211> LENGTH: 336

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 202

<223> OTHER INFORMATION: n = A or G



<400> SEQUENCE: 19



cccctgcaga aaatccatgc atcatgagtg tctcagggcc cagaatatga gagcaggtag 60



gaaacagaga catcttccat ccctgagagg cagtgcggtc cagtgggtgg ggacacgggc 120



tctgggtcag gtttgtgttg tttgtttgtt tgttttgaga cagagtctcg ctctattgcc 180



caggctggag tgcagtgtca cnatctcggc ttactgcaac ttctgccttc ccggattcaa 240



gtgattctcc tgcctcagcc tccagagtag ctgggattac aggtgcgtgc caccacgcct 300



ggctaatttt tgtatttttg atagagacgg ggtttc 336





<210> SEQ ID NO 20

<211> LENGTH: 21

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Foward primer



<400> SEQUENCE: 20



taaggtggga tggtcaactg g 21





<210> SEQ ID NO 21

<211> LENGTH: 21

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 21



caggagaatc acttgaatcc g 21





<210> SEQ ID NO 22

<211> LENGTH: 473

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 96

<223> OTHER INFORMATION: n = C or G

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 423

<223> OTHER INFORMATION: n = A or G



<400> SEQUENCE: 22



taaggtggga tggtcaactg gaaagcttta aattaagtcc agcctacctt gggggaaccc 60



acccccacaa agaaagctga ggtccctcct gatganttgt cagtttaact accaataacc 120



cacttgaatt aatcatcatc atcaagtctt tgataggtgt gagtgggtat cagtggccgg 180



tcccttcctg gggctccagc ccccgaggag gcctcagtga gcccctgcag aaaatccatg 240



catcatgagt gtctcagggc ccagaatatg agagcaggta ggaaacagag acatcttcca 300



tccctgagag gcagtgcggt ccagtgggtg gggacacggg ctctgggtca ggtttgtgtt 360



gtttgtttgt ttgttttgag acagagtctc gctctattgc ccaggctgga gtgcagtgtc 420



acnatctcgg cttactgcaa cttctgcctt cccggattca agtgattctc ctg 473





<210> SEQ ID NO 23

<211> LENGTH: 24

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 23



ccctacctta ctgtccgcct ctca 24





<210> SEQ ID NO 24

<211> LENGTH: 24

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 24



gtgctacctc tcgggaaaac ataa 24





<210> SEQ ID NO 25

<211> LENGTH: 169

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 90

<223> OTHER INFORMATION: n = T or C



<400> SEQUENCE: 25



ccctacctta ctgtccgcct ctcagagtcc ttcctgccag ggctgcctgg gaactggccc 60



accctaggcc ctgaaatagc atgatttgcn gagccagctt ttatactaaa tgggaactat 120



tggcaccttt ggcttcttgt catctttatg ttttcccgag aggtagcac 169





<210> SEQ ID NO 26

<211> LENGTH: 17

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 26



gagcaaccgg cgtatcc 17





<210> SEQ ID NO 27

<211> LENGTH: 21

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 27



ggggtttctt tctggctctc a 21





<210> SEQ ID NO 28

<211> LENGTH: 324

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 108

<223> OTHER INFORMATION: n = A or G



<400> SEQUENCE: 28



gagcaaccgg cgtatccatt tcagagaggg gctgagcctc actcctgctt cttgccaact 60



tctttacaag ggcactgcag gcaaagcttc agggagaggg gacaaatntg agtctaggaa 120



agaactattg tcatttccag catcagctgt ggcggctacc tcttgtattg gcctcacccc 180



tgaccttcct gtcctaacca aagaacgaga ggaactgcca ctgcttaacc ctttgttggg 240



ctgtgctaat gaaattgaag ggaacatggt gagcatgcga ggactgtgag agccagaaag 300



aaaccccgag caaccggcgt atcc 324





<210> SEQ ID NO 29

<211> LENGTH: 18

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Forward primer



<400> SEQUENCE: 29



ccagcaatgt tgaggaat 18





<210> SEQ ID NO 30

<211> LENGTH: 18

<212> TYPE: DNA

<213> ORGANISM: Artificial Sequence

<220> FEATURE:

<223> OTHER INFORMATION: Reverse primer



<400> SEQUENCE: 30



cgcaggaagg tgtggaga 18





<210> SEQ ID NO 31

<211> LENGTH: 418

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 232

<223> OTHER INFORMATION: n = A or G



<400> SEQUENCE: 31



ccagcaatgt tgaggaatgc agggtgtagg ggagcagaaa ggccactctg gtgtggcctg 60



acttgggacc atctgtccac tcagacagag ctcagcaaac ggtcaaggag ctgagaatcg 120



gctcagtccc tccctctccc tctcactctc ttcttccctc tttcccctcc ccactctctc 180



agcccctcac ctagctagct gcccctccct tacctcgcag gaccccctgg gntggaactg 240



cttgctgagc agttctgatg aaggcaggac cctttcctct ctgtggactc agtccacagt 300



gtctgtagac actggccctc cagaggacca gtgtgtgagg gggtgttgcc agcctctgtt 360



tctcctgagc cctcctccca agtgcaagta tgagaactcc tctccacacc ttcctgcg 418





<210> SEQ ID NO 32

<211> LENGTH: 353

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens



<400> SEQUENCE: 32



agatcacccc caacaatggc cacagctgtt ttcatctgcc ctgaaggaaa ctgacttagg 60



aagcaggtat cagagagggc ccttcctgag ggggcttctg tctggcttgt aaaactgtca 120



gagcagctgc attcatgtgt cggatgatgg atgatggaaa ggacagtcgg ctgcagatgg 180



acacagcgac ttgcaagttg aggcaggtgg caaaggactt gcagaggctc tgcaggtggg 240



gcatgctgat tcattgccca gttaaaatac cagaggatct gggcagcctc ttcacaggag 300



ctgcttgtcc tcaaacaatc tgtcttcaat gaaagattcc tctggccttc ctt 353





<210> SEQ ID NO 33

<211> LENGTH: 435

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens

<220> FEATURE:

<221> NAME/KEY: misc_feature

<222> LOCATION: 172

<223> OTHER INFORMATION: n = C or T



<400> SEQUENCE: 33



aggtggggct ataagcatcc atcctacctg ctcaaggaac ccaggcatca gaactgctct 60



ctcccaagtc cattgcaaga aggcagtcgt ctggtcatga gagggttaac agtccacatt 120



ccagagcaag ggaaaaggag gctggagggt catagacaag gggaggtggt gnggagggcc 180



agcttctcac aacactaccg gctctgctgg gagagataga tcacccccaa caatggccac 240



agctgttttc atctgccctg aaggaaactg acttaggaag caggtatcag agagggccct 300



tcctgagggg gcttctgtct ggcttgtaaa actgtcagag cagctgcatt catgtgtcgg 360



atgatggatg atggaaagga cagtcggctg cagatggaca cagcgacttg caagttgagg 420



caggtggcaa aggac 435





<210> SEQ ID NO 34

<211> LENGTH: 94752

<212> TYPE: DNA

<213> ORGANISM: Homo sapiens



<400> SEQUENCE: 34



ggatcagggg ttagagcctt ggcatggaga cgcctgaaag gcacccaagg caattagtgg 60



tgtcccttct ccacccccta cataccttca ggccctttgc acttgctgct ccccctccca 120



gtgcacacac ccccagatcc ttgtgtggct ccctctccca ccacattttg gtcttagctc 180



aaatgccacc tcctcagaaa tgcctggcct ggccgccttc agggctgtct atatgctcac 240



cagctttatt tttctttcga gaactttcca ttcccggaca ttgtactaaa tgtttatttg 300



ttatccgtcc attatccatc tccttgccag cactccctgt gagctccatg aggctccaag 360



attacaacca catgcccaga gctagggtgg tgcctggctc acagctggca tccagtcagt 420



agcaatggaa tgaatgaatg atcaccctct cttcctctcc atccccaccc tctccttttt 480



cacttcctct cccgccccat ctcccctgcc tccgccttaa atctgctggc atgaccagcc 540



ctcaggaagt tgtcaggcag gggaggtgtg tgctctgcac ccctctcctt ccatctctct 600



ttcccacctc ccttatgggt acctatctct cctacctgca gctgctcgct gccagctctg 660



gccctcttgg tgggcagaag cttaggcacc ccagacaatt gtagggaaat tgggcattgg 720



agggcagccg taagaaagga ttcagtacct gccaaggaat gatgaattta gtctctcacc 780



catgaacagg catgcacttt cagggctcag gttcggtctc taaagcagaa cgtcattcag 840



ggcacccttc agtacccatg acccagtgtc tcgcctttcc tgcaggagtc ggtgctgcca 900



ctatggtgac tcagcccctc tcttctcctc attcattacc tgggttcttc ctgcagtgat 960



tgacagtatc ctttttcttt tgagatgaag tcttgctctg ttgccagggc tggagggcag 1020



tggcacaatc ttggctcact gcaacctctg cctcctgggt tcaagccatt ctcctgtctc 1080



agcctcccga gtacctggga ttacaggtgc atgccaccat gccttgctaa tttttgtatt 1140



tttagtaaag atggggtttt gccatgctgg ccaggccagt ctctaactcg tgacctcagg 1200



tgatccaccc gccttgacgt cccaaagtac tgggattaca ggtgtgagcc accacgccca 1260



gcaagttgca gctcttaata gcatgggcac catataattt actgcccaga ttgggtcatt 1320



ttttagagta gaagtgggag ctgttaataa ttacgcttgg cctacaggtg taaacgagac 1380



caccctgggc aaaccaggca catggtcgca ttgactaaga ggaatattcc cctgcctcct 1440



gcatctccag ccacaaaagg agcctcagct gttggtcaaa gctgcccaat agctgagccc 1500



ttgcctgccc ttggacaagg gagaagacag agggcaggtt ccaagaatgg ggtggggatg 1560



tggcaggaag gacggtgcag gccccagagc tataatcaat gatctgggag ccgggttgtg 1620



gagcacaggg ctgtgtcaag gagcaggtgg gaggtgggcg ggtgtgggac atggcaccag 1680



cttttggtgt ctgtgactct gaacttggct tactcgcagg tggcttctgc aggctctcca 1740



ccctcccagc tgcgtaagtc ctgcctgatt caaggaaaac agggaatttt ggggtcctgt 1800



ggctcctcca acgttctttt cctttacctc cttgtgtaaa tgtggcctga tttgtacttg 1860



gagcataagt agacccctac agagcgtgtg tgtgtgtctg tgtgtgtgtg tgagagagag 1920



agagagtgag agagagagag agagagagag agaaagggac ctatttcctt ctatccctct 1980



gtctgtctta ctctcagact attaatacaa gccctgagtc tggctgtacc cccagaacat 2040



gtgccccgcc ccctacaaca aaatgctgcc cctcccagct aggtctgttg tttgttcctt 2100



ttctgattgg cgccaggctt atagacccca tgtaggtaga atataacttt ccataaataa 2160



cctctaaccc gacctacaat ttagccttca ggtttttttc cccctcgtgg taatgggatt 2220



gcagcctggg ctgatccatc ctgtatcttc aggtcccaga aagcagaccc taggtttgga 2280



cattgcttgg aattcctggt acccccatgt tgccttgcac atggcaagga ctcggtacat 2340



gttgaggaat ggtggattct cttctaccca tgagcagcca tgcacttgca gtctttgctt 2400



gggctatgcc ttctgcctag aagccccctt ctccacctgg aaaatctcta agcaacaccc 2460



actttgtgaa gctttcccta accactatcc ctcatcccct ccacagagca aattactcct 2520



atcttggatt cccataacac ttggtacaaa acagtgtgac ctggttattg cccatgtgcc 2580



caccaggttc taagcagctc aagtgagggg tagggcaagg aactgagccc aagtatggct 2640



gtgggcaaaa catttaaccc cttggtgctt cagtctcctc agattcaaac accaacctgg 2700



ggctgggtgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcaggcaga 2760



tcacttgagg tcaagagttc gagactagcc tggccaacat ggtgaaaccc cgtctctatc 2820



aaaaatacaa aaattagcca ggcgtggtgg cacgcacctg taatcccagc tactctggag 2880



gctgaggcag gagaatcact tgaatccggg aaggcagaag ttgcagtaag ccgagattgt 2940



gacactgcac tccagcctgg gcaatagagc gagactctgt ctcaaaacaa acaaacaaac 3000



aacacaaacc tgacccagag cccgtgtccc cacccactgg accgcactgc ctctcaggga 3060



tggaagatgt ctctgtttcc tacctgctct catattctgg gccctgagac actcatgatg 3120



catggatttt ctgcaggggc tcactgaggc ctcctcgggg gctggagccc caggaaggga 3180



ccggccactg atacccactc acacctatca aagacttgat gatgatgatt aattcaagtg 3240



ggttattggt agttaaactg acaagtcatc aggagggacc tcagctttct ttgtgggggt 3300



gggttccccc aaggtaggct ggacttaatt taaagctttc cagttgacca tcccacctta 3360



gggcaactga agagtaactt tagggttact cttcatctga agatgctaac tcagctagca 3420



tccagcacta ttaagacacc ttggggaggc gagactttga gagaagtgca ggaggctggc 3480



ccacttttga agatcctaca tttctaccca ggaggcatca aatccacact tcgaagaaga 3540



tgaagtttcc tgtgagctgg tcctgaattg tacttggctt tgtgttgtct atgccagtac 3600



taagcaggac ttggccaggc tggtcctcca tgaatgactg tcaaatggaa aacagaatta 3660



ggaaccaaag tagtggtgta gacaaaaggg gctggaacct cagaggagag agggatcatg 3720



ggagattgga acatctctgg aaggttaggg gaagagatga caagtaatgt gaatcctaaa 3780



gaaagaggat tagttattgg gggtgctaag tgtggatggc aaactaagga agcagggatc 3840



tgcatgacca tttggagtca gtaggaagct tggtggagtg ggaggtggga gtcaagcaga 3900



gaaggcctcc catgtcagat agggaaactg cacttgatcc tgggcaaggg ggagctatgg 3960



aaggcttttg agcaggggag tgatacaatg agaacagcat tttggaagcc agcatggagg 4020



ggaggctgct aaaaggatac aaggctgagg ttattaccat gccctgggtg aagaaatgcg 4080



gtctgggttt ggaaaggaag ggataaacat gacttttcaa aggaagacat aattgccaca 4140



agggccacca gagagcagtc aaaggtgtgt ccaaggttgg agctctagtg accaagagaa 4200



gggtgtcaac tttgacagaa atgacgtcat gtgtggttga caaaatgaga ccacatcctt 4260



tcggtcatga ttcattgtct ttattaacaa tgtctctgga ctctggaaga acagactgtt 4320



aattcataaa gcaatattaa cattgtcatt ctctacaaga aaaacttttg cataaataac 4380



ttaagtgaga aaataaatat gtaacttaac tctttaaaaa ccactacttt cattcttgtg 4440



gacaagtccc acgtggaaga attgccaaaa aaacgaccag tcctgcaggc tttcatatgt 4500



catgtgcttc tgtttaaaac tttttttttt taacaattaa aaactacaca gaaagtaaga 4560



ggttgtctgg aaatgatttt caaaaagatt tttgggtggc agctattatg ctctgcagtt 4620



tctcagcata tgtacagcac ttgtagtttt tcccccaata atattctttt agtgtaagat 4680



atgccatcac atgtaagagc agtaagaagc tgttttctag gcagaaatgt gtccgtgagt 4740



ggtgggcaga aggcggtgtc tcaaaaggga tgtgctggtc tgtgagtttg tgatggctgc 4800



tccctcgggc ctgcaaggcc agtgtccttg aacctttcac ttctcttcgg aaggtgactt 4860



taaaacatgg ctatgggtcg ggggagggat gctgctcttt gggaagttgg ggcggatgtg 4920



atttctatcc ctcccaccac cctcggaccc tctccttttc taccccaatg gatgatgtta 4980



tttctttgag atggaggggt ggaggtagcc aaacatccgg ggaagccagg ctgggaagca 5040



gcatagcttc ttccaggagt ttgtcagccg taaatatgtc agccataaat agactcttta 5100



cttttttttt tctgtttgtt tttcatcttt ggctgtcaga agagagcatc acaactctga 5160



attctggaag tgaccttggc actgaatcaa tgcaactgca ttcattctct ctctttctct 5220



ctctctctct cacctctgcc cattcaaaag gcactggagt ccttggaatc atatgccaat 5280



agtctcctcg agatcctatt cccacctcca ccctcatttt acaaagtgga aattgaggtc 5340



ccgaaggaga attgtgtagt tcaaggttac acagcaagtt agtggcagag ccaggactag 5400



aaaccacatc tacagttgcc cccagtcttg tgctctgggc acgcctcagg ctttctgatg 5460



ggcagcgagg tgcaaggggg aatcttatcc aactttctta accagtccct ggactttccc 5520



actcccacac cgctccctta aaaccccagg gcggtgaaaa tgcttccatt tctgcctcct 5580



ctgaagtggg accagcaaag gtaggcggcc ccagaggcgg ggctgcgtgg ctcagtgtct 5640



gtgactctca attccctccc ctgccccgtg ggacccctca gctggcgggc tgaggggggc 5700



cttgccggcg cccgggattc ctcagggcct ggaaggtctc agccccctgc cctgggttgc 5760



aggcatttac aatgaaatat aaacaatcaa accacgcgca gaggacagaa atgtggggcg 5820



cgggttcagg gccggggcgc ccgccggtgg ggaggggcgc gggcgggctc tagtaggcgt 5880



tctccagctc ggcctggttg gctttggcgc tccgggcgcg gggccgcggc ttccggccct 5940



tctgcggccg agcggcctcg gtcccgaagt ccttgagctc cgactggttg tggaagcggg 6000



tgaggcgctt gcacttgcac gaggccacca ggcgcacctt gcgcgcgcgc ggcgcctcac 6060



caccgggaca cagcagctgc acgcgctgcg cgcggtagcg gtcggggatg cagcggaagt 6120



cgggcccact aggtcgccac cacttgccgc ggccgatggc gttgggcagc aggcgcgccg 6180



ggccgcactg gccggagcac accagctcgg tgaccggctt ggcgctgcgg cacggcccat 6240



cggtcacgta gcgggtgaag tgcagctcgc ggcagctgta ctcggacacg tctgtggaga 6300



gaggcgcgcg tgagggtggc cgcccgcctg gccacccctg ccctggaccg gcccgtctct 6360



ctccacccca gccctgcttt tgccaagcct gtctccagag gcttttgccc ctgaacatct 6420



attgcaggaa ggtcccagat gctctagagc tggtggaaag ctctcctgcg caccctgtcc 6480



cctcggagcc aaatgactgc tggggttcaa acaccagggc tccatcgctc actgcaggtg 6540



tcatcttggg caagttcctt aacctctctc ttcttcctgt ctgcaaaatg ggccgcccca 6600



agcattgcga gttaatccat tacacacgca atgcagaaaa taccatttgg cacatatagc 6660



tgaaagcgtc ggctgttatg tattattatt atcatttctc ttctggggtc ttcttatgat 6720



ttaagccaca cttgtgccgc agggtccctg gcctgggcag ggtaagtact cagcacacct 6780



tctgcctggc tctggcttct cccaaattcc ttttccagcc acttgggagg ggtggacagg 6840



ggatggagaa aggagtagag gttaattgaa ggtaataaat cagggcagct gctgtggagg 6900



cgagggactg aaggggaggt gatcaggaca ggaattcatt agacttgaaa ggaatcaaag 6960



gcagtgtgtc caaccccctc attatcaatg agaatactga ggcccagcca gagaaaagaa 7020



cttgcccaaa aggctgggct gcatctccgg actccacttc cctggggtcc cagcaccttt 7080



tggctccggc aagagtggag gctctgcgtt cgagcatcca tgggaggctg ggctggggga 7140



tggagctgag ggctgctttt tactgtcgtt actttcctac cataggggcc ctgagctctg 7200



acccaaaacc tacaggttca gctgccacaa acattgacct ggctctctgc tgggcacatt 7260



tcttgttctg tgttatctga atgggcgcct catggtgata ctccctgggc aggcagagat 7320



tgggctccga ggcctggcct gatcccctgc acacaccttg accatgtctc ctatggtgga 7380



cttagatggg tgggagcttt ttaaatagct ggtcgtcgtg tgagtaccag tccaccccca 7440



aaggtttcat ggggatagtt ccaatgtgac aagaaagaat gaaaaatagt cttaagacca 7500



aaccagagag gggacagaga aggccacccc ccacccccac tctgaagagc aagcacagca 7560



ggggagatgt ggccactgcc atcgtctggg gctgctttct ggtctgtggg ctggtttgca 7620



tcctcacctc tgcagggctg gaatgtgtgt gtggtcaggg gggcatttgc ccagggaagg 7680



gggcattttg cggcttttcg agaatagcgc ccctaggcca ggcacttcct ctgcagatca 7740



tgactttgtt ttgagcatgt ggcttcctca ggggctgtgg cctctcgtgg gagtccagca 7800



aggtggacat tttgtgtttg ggttccttac agcccttcag gcagtcgctg gagcccagct 7860



gaccttgcct agaaggggag ctgtgggggg aggcgccctt gtcctccatt ttgaagacgg 7920



agggtcctgg ctggcctccc atgcagttgc cctttttagc accccatagt cccaacaggt 7980



tgtgaggcgg ggagggctgg ggtccaggag cctgggcagt ggacttctct gccacctgga 8040



taatggccag aggacaggga agctcttagt ctgaagtgtc atttcagacg cccccatggc 8100



ctcaggattc ctgccaatta tagagccaga tgcacactgt cacctgggct tctctgtgca 8160



ggcctgacca ggaacccagg gttcctcttc cttctccctc ccctggaatg aggcaaggtt 8220



gggactgggg tggctgctga ggacagatgt ccctactcct gcacagagga tgctgctctc 8280



ccctccaggg cctggactca gctgcaccca tgtcaggggc taaaactgtg ccgaaaactc 8340



ccattccttc aagtgccagc tccctgggca ggccatgggc aatgcacact gcaggggtgc 8400



ctctctggcc ttcctcccca ctgctttgtg gagatctgtc ccccacaccc ccccacacac 8460



cagggctatc ttgcagttgg atcaaaccag gttcacacct cagctcttct cactaccaag 8520



ttactgagtg cctggaacct gtttcttccc cttcgagctg ggggttcacc tcctggggat 8580



tccatgatgt gggtctgtgt ggtggggaca gccaccacca gcatagagtg tccggtgccc 8640



cacaggtgct gttctgtgga tgggaggctc ccttaccttg ttcccttccc agtggtacca 8700



gcagctggac gtggctccta tattcccagg aggagattct ttgaaacctt ttcttttctg 8760



agcccctgag cctgttctga tgccctgatg ccataccctc accaccccag cgtcctccct 8820



gccctgggct ctcaccagcg tctgttgcct catgcctctg cacctgaatt tgaaggctgc 8880



accagcgagc cattcttccc ccacctccag gcaagactgt tcctcgacca gtgctggcag 8940



aggccagcaa tcttcactgg gtctacccca gtcttccaag cctcccaaag agaagtttct 9000



aaaacctccc caggatcttt tactaagaat tctctcctcc accccatacc tttggtctca 9060



aaggggtggt ggggaggccg ccctccgttc tccgcccggt tcatggtctt gttgttctcc 9120



agctccggtg gaggctcggg gtactctccg agctcgggga tgatttccgt ggcatcattc 9180



ttgaacgcct gccacccctg gccctccact acacggaagg ctgtgtgtac cagcaggcag 9240



acgagacaca gggccagtgg gagctgcatg gtaccagcca gaggagggca cgccaccttc 9300



cagtagcaca ggctctggtc tccagccgag acacggtcgc ctttttaaag cccctctctg 9360



cttcatgcca gccaatgagg acaggctggg gcagggctgg tcccatgttt ccctcagccc 9420



cggagggagg gaaaggggtg tgctcagagc aaaccctccc caaagacttc tcctctagct 9480



cagcaaactt ccaaattgct gctggcactc ccaggtgacc cagagagagg gggcgtgtga 9540



ggcaaggccc aagcctgctc tccggcacct cccacgtgct ggcggctgtg gttttcagat 9600



atcaaaatga gctccggctt ttaattgtct gtctccctgg gccctcgggc attctcaaaa 9660



caaactgtgg acccgctcaa caaagaaaat gtgcagttct gagtgcttcg cggggctgag 9720



cccggcctat tccatttctc aggccaagtt catttgtcac cccaccaaca aatggcccaa 9780



ggtgtttctg tttgaccccc atagacccag ccagaggcaa aaagatgctt ttaaagaaat 9840



cccattggtc ccaactccac aagtctcagc attcattgtc ctaaccaaga aagcctctct 9900



tggtattctc tggaaggcaa gagagagaac tagagggtca gagcaagggt gcccgcttgg 9960



gagagagggc aggattctgg ttacaaatcg aggatgcgct ggtcactcag gctcctgtga 10020



tggacagcac agaggaaatc ccagctcatg ctcctcaggg atcctgtgca ctgtgacagg 10080



cacttctgag ccagggcact cactgtggct cgcagggtga tgtgctgaag acagtcattt 10140



ccccaaccag tctgtgtgtg tgagaagaca acaccaaatt cctttcctta gcaaaagcca 10200



cagccagcgt ttttagtgct gacattttat tttcttgtct tccagctggt tacatttttc 10260



aaaaacagtt ttgagtcctg tatggaaagc ttcattggtg cacaccacag gatgtgttcc 10320



atgaagccat cccaggacca actggtcaca aagaagctaa gagaaaatgc tgccttggcc 10380



ctgcatataa tgagccacac agggccgggg cggggggcgg gggcgcaggt agaggcgtgg 10440



gggagaagga ttcacacctg aggtgcaaga agagaaagga aggccagagg aatctttcat 10500



tgaagacaga ttgtttgagg acaagcagct cctgtgaaga ggctgcccag atcctctggt 10560



attttaactg ggcaatgaat cagcatgccc cacctgcaga gcctctgcaa gtcctttgcc 10620



acctgcctca acttgcaagt cgctgtgtcc atctgcagcc gactgtcctt tccatcatcc 10680



atcatccgac acatgaatgc agctgctctg acagttttac aagccagaca gaagccccct 10740



caggaagggc cctctctgat acctgcttcc taagtcagtt tccttcaggg cagatgaaaa 10800



cagctgtggc cattgttggg ggtgatctat ctctcccagc agagccggta gtgttgtgag 10860



aagctggccc tccgcaccac ctccccttgt ctatgaccct ccagcctcct tttcccttgc 10920



tctggaatgt ggactgttaa ccctctcatg accagacgac tgccttcttg caatggactt 10980



gggagagagc agttctgatg cctgggttcc ttgagcaggt aggatggatg cttatagccc 11040



cacctgctgt tgggagcggc tggaccgtct gcattaaaca gaggcagtgg gattcatccc 11100



tggaacgcgt ctgccacctg ctggagacaa aaggaggggt gactgcagga tggcaagtct 11160



caggactgga cgtgatttcc tttcctttcc tttccttatt tggaagtgaa gtaatattaa 11220



aaggaaaaag aagaatccag tggacttgaa cctctaaatg atccacaccc ctctgaatgg 11280



ctcagcgaga acctgctgtg acatcttctg ctgtttcatt taatgttaag tcattgacag 11340



ctgtttattt ttactcagtc cacaaacttg tcattgttca cagtattccc tggaattaaa 11400



cccccagggt tttagctgat tcctattgtg agtagtttag gttatttcca attttttttc 11460



ctatttccag cagggttgct atgaacatcc ttgtacggct gaaatttttt tttttttctt 11520



tttttggcag attctctctg tggcccaggc tgcagtgcag tggcacaatc ttggctcact 11580



gcaacctcca cctcctgggt tcaagcaatt ctcctgcctc agcctcccga gtagctggga 11640



ttacaggaat gcaccaccac gcccggccaa ttttgtattt ttagtagaga cgggggtttc 11700



tccatgttac tcaggctggt ctcgaacttc tgacctcggg tgatctgcct aactcggcct 11760



cccaaggtgc tggggattag aggcatgagc cacaatgccc ggcctcagag taatttttta 11820



aattaaaatt ttaaaatgtg gatataatta taaatttaaa tatacttata agaaataaaa 11880



gcctgggcaa catggtgagg cctagtctct acaaaaaatt taaaaattag ctgggcatgg 11940



ggtcgcacgc ctgtggtctt agctacttgg gaggctgagg tgggaggttc acttgaggtt 12000



gaggtcgagg ctgcagtgag ccatacttgg gccactgcac tccagcctgg ttgacagagt 12060



gagaccccgt ctcaaaaaat aaaaataaaa aaaagaaaat gcagactccg tgtatccttt 12120



atccagtttc ccacaacaat aacaccttgc gaaactatag gacaatatca caactaggat 12180



attgatattg acacaattta ccaatcttac ccacatctcc cgtggcttaa cctctactgt 12240



gtgcgtgcac acgcattcac gtgtgtgtat acttagttct atgcaatctt gtcacgggta 12300



aatttgggga tccaccacag tcaagataaa gcacagctct gtgaccacaa gtctttctcc 12360



tgttgcccac ctccttccct ccttttccct ccctcccaca actaacccct ggcaactact 12420



catctaatct ccatttctgt catttttttt ttcacttcaa aattgttaca taaatgcgac 12480



caggtgcggt ggctcactca tgtaatccca gcactttggg aagccaaggc aggcagatca 12540



cttgaggtca ggagttcgag accagcctgg ccaacatggc gaaaccctgt ctctactaaa 12600



aatacaaaaa ttagctgggc atggtggcac gcacctgtaa tcccagctac ttgggaagct 12660



aaggcaagag aatcgcttga actcaggagg cggaagttgc agtgagctga gatcgcgcca 12720



ctgtgctcca gcctgggtga cagagtgaga ctgtctcaaa aaaaaaaaaa aaaggttata 12780



taaatggaat caattagtat gtagcctttg gggatttttt tttcactcag cattatttcc 12840



attatccaag ttgtacatat cagtaacatg ttcctttttc ttttcttttt tttttttttt 12900



ggctgagtag tattccacaa agtttaaaaa aacaaaacaa aactttagag ttatttctgg 12960



aagtgaatgc tgtgtctgag ggagtgtgaa gagtttggtg gtctgatgag ggtattgcag 13020



ggctgttttc cagaaaactc agcccagtcc ccgccctcac ctgcaaaata gaggctccca 13080



taggtggtac tttgatgagg ctgccgtaac taagtaccac aaattgggtg gcataaacaa 13140



cagaagtcgt ctcacagagc tggaggttag gagtgcaagt tcaagacatt ggcagagttg 13200



gttccttcga ggacagtgag gaaggccttt tacctgcctt ctgctggctg ctgacaagct 13260



gtggcattca ctggcttgca gaagtgtcac ccccaatccc tgccttcatc ttcacatggt 13320



gttctctctg tgttcgaatt ttcccttttt tctaaggagg tcaggcatat tagattaggc 13380



ccagcctaat gacctcatct taacgagtta catctgtaat agccctattt ccaaataagg 13440



tcacattctc aggtactgtg acttaggact tcaatatatg catttgggag gaatgcagtt 13500



caacccataa ataagactgt caacactggg tttgggatgt tgattttttt tttttttttt 13560



gagacagagt ctcgctctgt cacccaggcg ggagtgcagt ggtgtgatct tggctcatat 13620



aacctccacc tcctgggttc aagcagttct cctgcctcag cctcccgagt agctaggact 13680



acagactccc gccaccacac ccagctaatt tttgcatttt tttttgtttg ttttgtagag 13740



atggggtttc gccatgtcgg ccaggctggt cttgaactcc tgacatcagg tgttcccaca 13800



atcccataaa gtgctgggat tgcaggcggg agccaccgca cccagccgat ttttttaaac 13860



attgaattta acagttgaaa cttaatttcc agaaaagctg cttttccatg tgattattta 13920



ccagcttttg tttctgtcga gttgcttctt ctgatgttca ctcgccaaac gtttaataaa 13980



gcaaggggga cacgcactcc ctctccagga gctcgcatac catggaagaa ataatttccg 14040



catccaaaca actccactac cagatggaag gtgatcaatg ccactgaaaa aaaggttcag 14100



atgctttttt ctaaaaaaaa ctttattttt tttctggagc acttttaggt tcacagcaaa 14160



actgagtgga tggtacagag atttctcatt tatgtcctgt gcccacacat gtacagctgc 14220



ccccgttatc aacatcccgc caccagagtg gtgcatttgc tatgattgat gagcctacat 14280



gacacatcat tatcacctga agtccatggt ttacatcaca gcactagtgt tgtacatcct 14340



atggctttgg acaaatgtat aatgacatac atctaccatt atagtatcat acagatgggc 14400



agtattttca ttgtccaaaa aaactatctg ctctgcctat tcatccctcc ccgactttcc 14460



ccaacccctg gcaaccactg atctttttac tgtaccttta tttttgcctt ttccaggatg 14520



tcatatagag ttggaatata cccatacata gtcttttcag attggcttct ttcagttagt 14580



aatattcatt tggggttcct ccatgtcttt tcatggcatg aacagcttat tttttttttt 14640



agcactgagt aatactccat cgtcttgatg tatcacggtt tatctagtca cctactgtca 14700



tctactgaag gacatcttgg ttgctttcaa gctctggcaa ttattaatag aggtggtata 14760



aacattttgt acaggttttt tgttttgttt tgtcttaaga cggagtctta ctctgtctcc 14820



caggctgggg tgcagtgccg tgatctcagc tcactgcaac ctccgcctcc tgggttcaag 14880



tgattctcct ggctcagcct cccgagtagg tgggattaca ggtgagcacc accacacctg 14940



gctaattttt gtatttttag tagagaaggg gtttccccat gttggccagt atggtctcaa 15000



actcctaacc tcaagtgatc tgcccacctc agcctcccaa agtgctggga ttacaggcat 15060



gagccaccat gcccagctgt gtgcaggttt ttatacgaac gttaagtttt caaatcattt 15120



gaataaatac caaggagcat gactgctgga ttgtgcaata aaagtatgtg tagttttgca 15180



agaaactaaa ctgcaaactg tcctccaaag tggctgtacc attttgcatt ccccactgaa 15240



acaaagagtt cctgttgttc cacatcctca ccagatgcat tttttcaaaa ggacaatttt 15300



cttatgggcc ttcaaaggag agaacaatct ctttcccctg gggaggatct gggatcctta 15360



tggtaagatg tggcatttgg accagacttt gaatgacagg ccaaatttgg aaagtatatt 15420



atgctccttt gactccttgg gatcatagaa tctttgatct ggaaggactc tcaaaggtca 15480



tccggtttca ttctctactt ggttctggag gaggccccta tctctaatta atggaaactg 15540



aggattctcc ttattggctg cattttaaaa cagattttgc tcccacttgt aggtggtaaa 15600



aaggaaatat ctggattagg agggcaaact tctgctttta ggcagtaccc tgcattgagg 15660



gatgtccaaa tcaccttgtc tttatttaca catccataca caatggaatg ctatgtagct 15720



gttaagatga agggggtaga gcaataaaaa caataaccat aatataagct aagcaaaaca 15780



aacaacaaag cagagatatc tctgtatata cacacgtatg cacatatgtg tgcttatata 15840



tgcttgacat tttcctttaa ggatatgatg cttatgggga gagagattga aggagcaagt 15900



gactcacttt tccgtataag ccttttgcat tgtttaagtg tattactatg tacatatagt 15960



attattttta atgaaaaatt ttttaaaaat tatacttaaa aacttttacc tgttttatat 16020



tttagtgctc tgccttaaga ttttgtgtag aaccataaag attacattgt cagagtcttg 16080



acaaatagga agcgagtcca attgcttcat gtgatagagg gaatgggaac ctcgagaggc 16140



tttctctgcc cagacttctg tctgggagga aaaggcacct actttctcta aggtttttta 16200



ttcaaaggaa catagcacca atagtggaat ttaaggcatc tgggggaagg ggatatgttt 16260



agggactgtt catttgcagg atcactcaaa tctcaaaatg tcacccagtc atcacgtgag 16320



gctaccttga gatgaacacc ctagtcccct gctttcttag aagcacaaac cttacctcct 16380



tcattcagga ccattatggc cattctacct aagaatattc ctaccagaac atttctggta 16440



ctggaaaggt gttcatcaat atctactgca taaacagtgc catcatggaa cctataacta 16500



gctcagaacg gctatgtttt agatgattat ttttaaaaag ttagaaatcg caaatataaa 16560



agctaagccc aaacaaaaaa agctaagcat aaaaacgtaa aagaatacca actgtgataa 16620



gaaggacaaa aaaacaatac ctttgtaatg taagacattt attttggcta aagttctggt 16680



gttttaacac tgatttgtga tacaacggac attaaacttc cttttaaaaa gaaaaaaaca 16740



atttggtagc tctccctttt ctgtccagaa aaattcactc tttcataatc aaattaccct 16800



aaaatttggt ggcgttaaga ggcaacaaaa gttaagcttc caacgaatct gttctctcaa 16860



ccggaaatgt cttctatttc caatcaggat aaaaccttga cttacttgca aggactatca 16920



cggttagccc ttcagtgatt cctgacacca gttctgtgaa aaagaaaatt tcctgcgaga 16980



aaagctcatg tcttcatatt gaagatcagt actttttttt ttttttttcc tttaaaacag 17040



tagcatctta acttgtggca caaaaggcac caacattccc tttccaaacc atccatcacc 17100



atgggtggaa ggcagcgcca cctgctggcc atcatattat ggctcacata cccataattt 17160



ccttgcggtg ctgaattcca agtggggatt attagagacc cctcagagcc aaaaggggac 17220



cttagaggtc ttctagatga gtcccctcat ttgtaggtgg tggtttctgg ataactcaga 17280



gtggcaggga cacagacgag cctgtggaaa ggtatactgc tttaagattg agaagaaaac 17340



catttggcgc tctaattttg cctggatggt gctctgtcag tcaaagaaag ggaacaggtc 17400



tggggagggg gtaagggcac cctgagttcc tgttccatca cttcccaggc agtagaaggc 17460



tgtccaggaa cagctcccat ccgcagctgg gcatgtgttg gctcttacac aagagacttt 17520



aattttactt gaagaactaa gagctaaatc ttgttaagta aatacggggt ttcaggggtg 17580



aaggactatc aagaaatccc aagttatcag cataaaagta gtcccaaagt aaaggcagta 17640



attctcccaa tggccttttc tccctcatgc ccccacagag actttcgaga ggtcctagtt 17700



agccagccac accaacctgc tgtgttcgcg taagtagctg tgcctgtccc atggggtgac 17760



cactgcctgg tcatgggagg ggagccccag ccccagctcc ctagcctttt ccaggagcag 17820



agcagaaagc tctactttgg ggtgctacat cccacctgga gaaagagctg cacattctag 17880



cctatgaggg acccaccctt ttcacttgct tctccggggc tggattgagg gtaagtgcag 17940



tacacctgga gatcccaggg agcccccttc ttgagaaaga gtatcgtatg aaagaatcca 18000



gcttcaggga gcagcaaacc caaaatcttg cccagctcca ccttatggag ctggacaacc 18060



ctgggggcca ggcccttaat cattctgaac ctcagttcct tttttttaaa aaaggtcaca 18120



atacaagaac aagctctact aactttacag ggttactgtg aggctcaagt tagattaagt 18180



tggaaggcta cctagaagct gtgcagtgag gtacccagtt tagaggatgg ccatttcact 18240



taggtgggtt tatctggaca cctttttcac tatctggaga agaagacaca tactggttgt 18300



tcagggctgc tgtggtcaca gagaaaagcg gacagcaaat gaccaggctg ggcagggctg 18360



cttctgtgtg atcagagacc ttcacagccg ggagtgaggc cttacgccac acctgcctct 18420



ccgtgtccca gccaggagct cctggccaac tctgaaaaag gcacattccc taccttggca 18480



tattaacact gcctgaattt aaatgtaaaa ctgagttgta aatagtcaac aaaagtccct 18540



gatatttctt ttgttttagg taagactcct tcacaaggcc ttgcgagtga tcctaccata 18600



aattcagtct tctgggagcg tgacacaccc accagaacaa tgccctatat atatttggtg 18660



ctcaaaaagt gtttaatttc ttaaactttt atcagacacc tatgtgcaag gtgctggggg 18720



catggctgag gaccttctct ttgcccagag tgaccctgaa gataaatagc atcacaatca 18780



ctttccataa taacaataac gtaaaatcct aacaagactg tatttaaaac aaaactctta 18840



tattctggca aatgtgcata cacatgtgag ggctggtgca ttccaatatc atccttagaa 18900



agtcttttga aaggtttatc gtgtttgggt ttttttgctc taccaccaat aaaggatcca 18960



tttggacact ccgccatgtc tcatgtctgc ctggctgagt cacttcaggg atcccgtgct 19020



ggcaccagag agctgtaaga gccacctgca atgggcaggg tgtgtgcctg ggacctttca 19080



cttccctgct tgtcttctgg ccgcgtttct gagaggcacg ccccccacac acatccatgc 19140



acacacgctg taattggcca acttcctcct tctgttcttg gaatagcaac cgagacaaaa 19200



agcagttagc acgagtggct tgggcttgcc aacactacaa ttcaggacaa aacccttgta 19260



attctccaaa tggtggggtt tttaaatagg ttggacttca actccctgtt ttctaaaaaa 19320



gaaaaaaaaa aaagcatgcc caaggcatca ctcttctcaa aaacgaagtg actgagataa 19380



gatcgaaggg aaatattcca gagcagcaga ttctgaactc aaggcttcca aagattcaca 19440



ttttgaaaac tctatggatt taggagggtt ctccaggttt gcccacaagg cctctttgtg 19500



tagggaccat tcatcctaag gaaatcattc aaatgcagcc ttgctgtggg aatctccatc 19560



cactaataac tgacggacac ccccacccca gcttcggacc tcaagacgtg agagggctgc 19620



ctatgcacag ggtgtggaag gctgtgggga cagtgcgggg cacagacgtg gtggggagag 19680



tggcctgcat ttgcatagtt cctttactag ggctcaaggt gttgaggtcc acactcaaga 19740



gaggattcgg gagttgggga agggaggtca tgagggacct ctgtgagcat cttaggcctt 19800



acacttccac acacctcctg ccgtgggcca tcgggaagca tgcaggccac aggccttccc 19860



cctctgagcc cccatctcag ggaaaagaca tcataagtta cagaaacagg acaactgggg 19920



agcaaggacg ccccccttgg caagcttctt tatgtgctcc ccagggtggg gaaagtggcc 19980



caggactgtg ttgggacaca cttgtagaca agtgccttgt gatgctggga gcagggtaca 20040



gtgtgtttcc taaacatggc agctcgggac acctttgccc acggcctccc ccacggacct 20100



ctcgagcaga ggcggtgggg gtgccctagg gtttcaactt cccctccttg gctagtctgt 20160



cattgagctg gcagagctgg gccaggaagc catcgttggg gccgatctca cggttctgcc 20220



tcacgatgct cagggcagac ttgacgtcca tcttctgccg catcatgagg taggcgataa 20280



ctagcgttgg ggagcggcta taaccttccc ggcagtggac gagcacccgg cctgtaagaa 20340



acaggggaga cgtggtgagc tgggggcgtc ccatcacacc atggcgttgg tcaagactct 20400



tccgtgaagt gccacttaaa agcacaatgt cacgccactg tgtgcctgtc agaatggcta 20460



aaatgaaaag gatggaaaac ccaaagtgct ggtgaagata tggggcaact ggaactcttc 20520



tgcgtggctg ggggaggtga ggcgtgaatt ggcacaacca ctttggaaag ctgtgcggca 20580



cggcggtatc tcctcaagct gaacacgtgc atcccctctg gcccagcaat cccactccca 20640



ggcccaggtc caatagagat acgcattcac attcacgaac atgggccaga atgttcacag 20700



gcaacactgc acatcatggc ccacagttag aaacccccaa aggcccatcc acagtagaaa 20760



ggacaaatac aaagaatgac cagactgcca cttagcagaa gcaacacgga ggcagcacac 20820



acatatgagg tggatgagcc cacagagtag gaaagcgggc aaaaccatct gtgctgtcag 20880



aagcctgcaa ggggctgggc acagtggctc acgcctgtaa tcccagcact ttgggaggcc 20940



aaggcaactg gatcacaagg tcaggagttc gagaccagac tggccaacat agtgaaatcc 21000



cgtctttact aaagatacaa aaaaatagct gggtgtggtg gcgcgagcct ataatcccag 21060



ctactcagga ggctgaggcc agagaattgc ttgaacccag gaggcagagg ttgcggtgag 21120



gtgagattgt gctgagattg tgctccagcc tgggtgacag agcgagactc tgtctcaaaa 21180



aaaaaaagaa gcccgcgtgg cagaggccct gggagctggg gatgggggtg gtggagcata 21240



gagactgggg gtgctttcca gggtgctggt agtgttttgt ttcttttttt ttgagatgga 21300



gtttccttct tgttgcccag gctggagtgc agtggcgcga tctcggctca cttcagcctc 21360



cgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg gactacaggc 21420



gcatgccacc atgcccagct aatttttttg tatcttttag tagagatggg gttattttaa 21480



tatagtgtgt gtgtgcgtgt atatatatgt gtgtgtgtgt gtgtgtgtgt gtatgtgtgt 21540



gtatatatat atatataaat agacaccatc tctcaatatc cacagggcag attggctcca 21600



ggacctcctg ccgataccca aatccacaga tgctcaagtc cctgattata aaatgacatc 21660



atatatgcaa ataacctctg cacagcacat cctcccctat actttaaatc atctccagat 21720



gacttatgat acccaagaca atgtaaacat ttattagatt atatcatcta gagaataatg 21780



acaagaaaaa aaatctgtac atgttcagta cagacataac atctttttat gttgttttta 21840



atatttttca gactgaggtt agttgaatcc acagatgtgg aacccacgga tatggaggac 21900



cgactgtata ttctattggt tctgtttttt ctagagaatc ctgaccaata cactggttat 21960



taactcatga tccacctaac ctcaaggtgc ctcagttttc ttatctggcc aatagtaccc 22020



attgcacaag gtggttagat taaaggagag gacacatgaa tcctctaggt tagcacctgg 22080



catccatgtg cactcaataa atgttaccca atactgggca tcctctggta gcacctagta 22140



caccctcaac tacagcagcc ctggtcctgt gtcattgcca gacatgcgca gattgacttt 22200



tctctcccag aggacgaatt ctttaagagc aagaaatggc cggacacggt ggctcacacc 22260



tataatccca acactttggg aggtcgaggt gggcggatcc cctgaagtca ggagttcgag 22320



accatcctgg ccaacatggc gaaaccccgt ttctactaaa aatacaaaaa attagctggg 22380



catggtggca catgcctgta atcccagcta ctcagaaagc tgaggcagga gaatcacttg 22440



aacctgggag gtggagggtg cagtgagctg agattgagcc actgtactcc agcctgggtg 22500



acaagagcga gactccgtct caaaaaaaaa aaaaaaaaaa ggcaagaaat gtggggcatt 22560



gatttttgga tgcgttacaa tctctagcat acactatgtg ctcaataaat atttgctgac 22620



tagctgagtg aattattacc tactaacacc tctataaggc cattgtttgg caaggaatct 22680



gctagcccag agtccaacag agtctcttct gctcctatca ccctaccccc aaaacaccac 22740



tctattttcc caatgccttc caaatcagga agcaggagtc ctccactttc ttgcccattc 22800



accctccggc ctgtatgccc gaaatattca gagtggggct tcccctgccc caccctagga 22860



atgagaccct ctgcagagca gccaccttac catctagaac atactctgca tgcccagtgc 22920



acacagagcc tactgggaaa ggggccagtt caacctccca ttcctctagg ctcagcccag 22980



atgccacctc ctccatgaag ctgttttccc agctagaagt gactgctccc tcttgagtac 23040



cctcagccat cccacccagc tctcagtgat gggtccctgg gccccacaca ctgttggagg 23100



ccagcatgtt tctgttgact cacttcgcca ctcattctta gaagcattta tacttggcat 23160



tagagcccat ggaattcttc atcacttgct cattcatcat ttgcagtgta cctactatgt 23220



gcctgatgct acatcaggtg ctaaggagac agacaaggaa caaagtagac ccagcctgag 23280



ggcaggcttc atggaagaga ggacaccatg ccaaggacaa ggtggagttt gccagaggaa 23340



ggggtaggga gaggcagaga gaacttttca gactaaagac ccagcacacc tggactgaga 23400



caggtcaaaa aaagggcgtg ttcctagttg tttggaaaga ggaaacaaag tcagagagct 23460



tgaaattccc tgaatgaata accaattgct attatacgag aacaacaaaa tccttcccct 23520



tcgcccagcc tatgtttaca cagggtgagg aactcagtac agctggagtg gaggaggtga 23580



gcagggttgg ggggtgacag tgaccaggaa ggaccatgag gggcctgtca gcaaagtctg 23640



cagatactcc acagtaaagc ttctctctga gccctgagcg ttcactgtcc agtggtctag 23700



aaaattctgt ttactggaaa tcattcagac agtgagcctg ctgggcccaa gagtcatcag 23760



tgtagtacag ccaaggctgt tcacacctca tgggggtccc ctccgctggg agggtttggg 23820



gtggggagag acgaagaggt aaagggagga gctgagagaa acagctaaaa gcagaaaggg 23880



agaaagggca agtggcccag cctgctcagc tgatgtctgc tttgtggcct tctagggttt 23940



cttgctggaa tgccttggtg actgccagcg ccttggtagt tctccttcag tcttatctta 24000



tatttggggg ctgcaggaag tgtttcgtaa gtggctggaa gatttggcca ggggggctgt 24060



ggtttgctga ctgccaacct aagctgaccg cagctacccc ttttctcctt gccaggcaat 24120



cacgtgaatc tctagccaat gagatgtgag gggtatttct gggaaatgtt ttacttgttc 24180



ttaaagagag agactgggca tggtggcacg tgcttgtagt cccagctact caggaggctg 24240



aggtgagagg actgcttgag cccaggagtt ggagaccagt ctagacaaca tagcaagacc 24300



ctgtctcttt aaaaaagaga gagagagtgg ccaggcgcgg tggctcatgc ctgtaatccc 24360



agcactttgg gaggcagagg gaggcggatc acctgaggtc aggagttgga gaccagcctg 24420



accaacatgg tgaaacccca tctctactaa aaatacaaaa ttagccaggc gtgggggcgc 24480



atgcctgtaa tcccagctac ttgggaggct gaggcgggag gctgaggcag gagaatcgct 24540



tgaacctggg aggtggaggt tgcggtgagc caagatcgcg ccattgctct tcagcctggg 24600



caacaagagt gaaactccat ctaaaaaaaa aaaaaaaaaa aaaaaaggag agagagaaga 24660



ggaaaaaaaa gagtgggaag agatggctgc agggcctcat ctgctgtact ttgtcctgct 24720



tggatgtggt gactggatcc catcttggga ccatgacggg agcacccaac actgaggtgg 24780



cagaagagag aaagggaaag ggcctggtcc agaggccacc atggagctgc tgaatcaagc 24840



agccccttaa tcaaccagcc cccatgctcc ttcacctcag gacttcttgc catgcacatt 24900



aacacattaa cacatcttcc tcatcgttac agctgtttga atgggggacg tgtaagcaac 24960



tggaaaccaa cctccagcca aagtgcagtc aaacgcgagg accctggggc tgccatggtg 25020



tgaatgagtt gcacatcctg tgacacacgg ggccacttga cagccagcca ggtgagcaga 25080



gagagaccta cagctctgtc gttcacccca gaagatggga aacaagggag tttctaagaa 25140



gagacctgtt gtgggcctgt tttccagagg gacagtccag tcagagctgc ctcccatctt 25200



ttcctggtgg gaggtccctt accattcttt tgagccaaag cctggtcaat gaagtcggca 25260



gccctttcaa agtaagcgct gaggttgaac tcctgtgtgt cgttggcctt gatgcccagg 25320



tatgtgatgc cggagtcctt gtagaagttg gcattggtgt tgacgtgcat gaaggacctg 25380



ccctcagccg cgttcagcac atgggtgatg cctagtttct gcagcttggg gatgtcctga 25440



gccacagacc tggacaggag acagtggtgg ggatgattaa ccaaccaaat ggcagcccca 25500



gggggaggaa gatggagaag gatttaagcc tcttagcaaa gcaaggaaac cctccatgct 25560



ctggcccctg ccagcttctc ctgcctcatc ttatgacctc ttccctcact ctggccatat 25620



cgaattgcca gcagcttccc caaatagact ggtggtttca tagccatgct gtcccctctg 25680



tctggaatgc tctttcccac cttctctgga gaaatgcgcc ctctcatctt tcacaccctc 25740



cgcagtgttt gtctcccctc cattccattt ggccccatgc tccctaagct gtggtggggg 25800



tgtacatagc caactggtta cagatgggct ctggaaccag actaactggg tctgcatcct 25860



gcccaggtac tagccaggca accttaagca agccatttaa cctttctgtg cctcagtttc 25920



cctctctgta aaatggggat aacagtgcct tctccttgag gttgttatga gtattaaatg 25980



ggctattcca ttgacagagc tggacacggt agtgagcact atgattctaa tgcttgattg 26040



tgcttctgtg tttagacatc cagactgtga gctccttgag agaggaacca tgtctgcttt 26100



aagtctgttt ccccaccatc tgctatagta cctgctacat agtaggtgct gaataaataa 26160



gcggtgaatg agtgcaaaag aataaatttg tcacgtacca ggcagccccc tccctgcccc 26220



cagagggatc ctacctgcca cattccactg gctacgtttc caaagctctt ttgggtgatt 26280



tagtacttgg ggagtaagtg gccccaacag aactatggga ggttacaaaa taatttatct 26340



aaggtcgggt gcagtggctc acacctgtaa tcccagcact ctgggaagcc gaggcaggtg 26400



gatcacctgt caggagttcg ggaccagcct ggccaacatg gtgaaacccc gtctctacta 26460



aaaatacaaa agtgagccgg gtgtggtggt acatgcctgt aatcccagct actctgggat 26520



tacagaggct gagacaggag aatcacttga acccgggagg tggaggttgc agtgtgctga 26580



gattgtgcta ttgcactcta gcctgggtga cagagtgaga ctccgtctcg aaaaataaaa 26640



taaaataaaa taaaaataat aattggtctg aatggtgaaa aggccccttt atttcatctc 26700



acaaaacatc ccagtccaaa tagcagttta tactttataa aatgccacct cctgtgtgat 26760



cttgcttgcc cactgcgagc agccctgtga ggaacaagga tggcaatatc cctgcttaac 26820



agagcttgaa ctcaggccca acaggatgag cagagggatg ggcacaggcc ccgtgtgctg 26880



ctggtggcag atctgggaga agacctcctt tctcccgaca tccagccctg ctctatcttc 26940



cacctcactc tgcccctcat gcccacatct gctgcaaaac ccccaaggcc tggcacatgt 27000



ggctcacaca ggctctggct ctgccttgtg aggacgtggc tgcggccctg attttgttaa 27060



gggaatggag cccaaatcct cttggtgctt ggtgctcact gatcctccct gttgaggaac 27120



ccccacaccc ctggccaagt caaggtcaga ggtgcttaga gggcaaggga tgtattttct 27180



acagtggcca tcagcaattg ccactctggc tacaccagac gtgtacaacc ttggtttcca 27240



cttgggaagt gatgacagct gaatggccaa cctgcccaag caagcgggat tcctgaggct 27300



aacaaggcct gcttgctgct tggtgcaaga ggaagggtgt ctctagagct ttccaattcc 27360



tgaagccttt ggctgacact gtgggactct gtttattcct gcttaggaca ccgcgcaaga 27420



ctgtgaagca gtggctgata gaaaaaaaca ctttgaagag tcactcccat tcatctccct 27480



tctctaatac tttttttttt tgagatggag tttcgctctt gttgcccagt tggagtgcaa 27540



cggtacgatc ttggctcact gtaacctcca cctcccgtgt tcaaacgatt ctcctgcctc 27600



agcctccgga gtagctggga tcacaggcgc caggcaccat gcccagctaa tttttgtatt 27660



tttagtagag acagggtttc accatgttgg tcaggctggt ctcgaactgc tgacctcagg 27720



tgacccaccc gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc atcgtgccag 27780



gcctctaata ctattaataa ttcaacattc aaaaaattta caattatcat tattactatc 27840



tctactatga atgaacattg tacagtgcct gacataaagc aggtgctcag actggtgaat 27900



gaatgatgga atggatgaga actgtcccca tgaggctggg gcctgatgga ccccttctag 27960



ttccatgatg acccccattt ccgtggcagt ccttggcagg ctaaacagca ggtcatagcg 28020



gaggtcagga aatacataca tgaacaagac attgaccctg tccttgtagt ccctcacaca 28080



ctctgagcca ccatttcctc ctctgtaaaa tgggaggagg gttagttttg agttttcaac 28140



atgccatcct tgggctgagc catgaagctt aggattttgg taactgggtc ctcagagtat 28200



cgtgaaaatc caacttgagg ctttccaagg ctgtacaggc atgctaatat attctttctt 28260



gaggctccta tttcacatct cagaatgtta acactggttc tttcctgctg attagacatt 28320



cttactagaa aaaaaattta aaatttaaat taaaaaaaat ctcttactgt ccgggtgcgg 28380



tggctcacgc ctgtaatccc agcacttttg gaggccgagg tgggcggatc atgaggtcag 28440



gagtttgaga ccagcctggc caagagacca gcctggccaa tatggtgaaa ccccgtctct 28500



actaaaaata caaaaagtag ccaggcgtgg tggcgggcgc ctgtaatccc agctactcgg 28560



gaggctgagg caggagaatt gcttgaaccc aggaggcaga ggttgcagtg agccgagatc 28620



tcgccattgc actccagcct gggtgacaga gcctgggggt gaaaggtcaa gagccttttc 28680



taggtggtgg ctcaggtcct taggggggtt atcactggac cgttctagaa tctcctgtaa 28740



atcaaatcac atctggaagg tgggggcctg gaaatcccgg cccagctccc cggactcgct 28800



catttggggt gtttaggttc cctgatccgg gactgccggg ccgggaaaat tccatgcccg 28860



aattgtgacg tcggcccgtt gccatggcgg cgaaggcaga cattccgcgg tgacctcact 28920



gcagaaccag gcagctgtca catgacgcgc gggcaggaga ccggccgggc gaccgagggt 28980



cacctgttaa gtgaacatgg tagccccgac cccgcccaag gccaagcccc aagcgggtgg 29040



cggctgggac ccgggcaggc gccacccggg ctccgtgcac cccgccacgg ggaagggccg 29100



cgcccggcca ggcagggttc cagttccttg gccccacgcg cgggggtagg cgtcgactcc 29160



aggcccctcc caagcccccg ctgtggctcc cggaggggcc atcgcgcccg ggctccccca 29220



acccaagact cgcgacaccc cgaccccagc ctcgggtggg cggggcgtcc cgagagggac 29280



ggcggggccg ggctcgcgaa agggactcac gcgttgccca cgtagatccg cggggtgacc 29340



tcgttgcagg gctggctcgg gaggctgtag cagccgctgc cgtccgagag caggtcgttg 29400



agatcctgca ccgagagctc gaacgagccc gacatggcgg cggcggggcc ctgcacgccc 29460



ggcaggagca agcgaggcgg agagcggcgg atcagctggg cgggggctcg cgccgggagc 29520



cgccccgtcc cgcccctggg gcgggcccgc cgggctccgg gagctgcgga gcgcgggcgc 29580



cgtgacgcgg gggccccgcg cgccactcct gggcgcgtcc cggggggaag acgccaccgc 29640



cctggagtct caggggtcct cgccccatcc cggtccaggc cgtttgtgta tctttgtaaa 29700



ctggcaagcg cggtaacttc cttccctgaa ttaaatgcag ggcccaataa acatttcgtg 29760



gcggaggtac acctaggggt cgcttcagtc tttcatgatt acagggaccg ccgggttcgg 29820



ctcgtgagcg gctccctgca gtggaggcac cacccgggcg cttgacagaa tccccgcccc 29880



agcccagccc tgctggatca gagtggacat tttacggacc ccaggaggtc cctacggtca 29940



aagtctgaga agccctactc tggggcgcat ctgctttcaa cattcattga gagtcatcgt 30000



cgtgcttaaa agcagtcagg tttggaattc tgaggaatta cttaacctga gcctgtttgc 30060



agggaaaaaa aaaaaaagcg ggatagtaat ggtacctaat tctagggttg ctggaagggt 30120



taaatgtgac attcaaagaa ggcacccagc actgcatggc gagcactcaa taggtgttag 30180



tccttcatca acaaatgcgt tgagcaccca gtgggtgcta taccctgtgc tggggtggag 30240



ataaatcaga ctcctgcagc ccttcctgga gcagatgcca gcccaccata agccactcag 30300



catttcctga actcccacta agtacaaaag atagtctctg tactggagga aagctgccct 30360



cccctactgc catgaaaaac tggcagtttc cttcctgcaa aagggcaaat ttggccttga 30420



attcaggaac cccacatcct gagcccagcc ctgccaccaa cttggttctt gagtaacgtt 30480



gctgctgctg tggtcttcag tttcctcatt tgcaaaagga attggatccg attatcatta 30540



gggtcaactt tctcctcctc caaaacttgt ggtcttgcac cttcagggga gctattgcag 30600



tggagactac ttagctgata gcccaagatg tgtaaccaag gctggaattt ctgtatccct 30660



caccccaccc cgtgcctgcc cacccctccc ggtgcaccac ttctttcctt ctggtgttgg 30720



ctggcagcat ctgcattcta agcagcgggg aaagctttcg agttccttga ccttcatctt 30780



gacttgagcc gaggttagca ttaaaaacac aagcccagag gcagccagcc atgctctgct 30840



gctcctactc ccttcccggg acctgtccct gatgtcataa ctgggtaact atgacagctt 30900



gtcatgggga cagctaggca cctcacagag gagtctgggt acctcatttc tgaagtgaga 30960



ctaggaagag aagatgaaca attccctgga ttatctggcc taccctgtta tcgtctctaa 31020



tcacaggcaa agcacaacct tcagaaagaa actggacttt ggccactacg tatctcacaa 31080



gaatagaata caaataggta tgtgggcagt ttgggctgga cactgctatt agggattttg 31140



gaatggtacc ccataaagag atcaacagga aaccagacca ggtcacagct ttgggatgat 31200



atggccttat ctgctgagtt tggggaagag ggcattagca ccaataacaa aatgtatctt 31260



ccaccaggga gttcactgga tggaaatact cctttaaact ccttaaagcc gaagtacgtt 31320



agaaagggga taagacttca gaagccaata gacaggctaa taatattgga aaaagattgg 31380



aagagaagct ctttcattgg attagaagga catttatctc tgtaaatttt attttcacta 31440



ttcttttgtt tctgctcaaa actctccaga gatgttcatt tgataaatca aaccaaactt 31500



cttgagtcgc attaaggtcc taattcgaaa ttgttcatta gtcaaggaca ttgtctagtg 31560



ctggttttct gaggccgcta ctggaattcc tgtgatgtaa cattgttccc ttttatcccc 31620



cttctctagc gaagcctact gttgatacca aacctccagt ggcgcacaca aatcacattt 31680



taaaattgag caaactacag gtatttgttc ttgctgcttg cagatgtgca gatgtatttt 31740



attgacttcc agtctgtttc ctaaagaggt tcaatttccc agagccttct aaatacccat 31800



ctactcaaag atttgttaat actcctcctc cccacgcgtc acccccagtc gtttttttcc 31860



cccctgatac ggagtctcgc tctgttgcct aggctggagt gcacaatctc ggctcactgc 31920



aacctccgcc tcccagattc aagcaattct cccgcctcag cctccagagt agctgggatt 31980



acaggcatgt ggcaccatgc ccagctaatt tttcatattt ttagtagaga caggggttca 32040



ccatgttggc caggatggtc ttagtctcat tacctcccgc ctgcctcggc ctcccaaagt 32100



gctgggatta caggcgtgag ccaccgtgcc cggccgccca gtcttttaag ttctgcttcc 32160



agtctccact gtggccctca atgcacccct ttcccacgat ctcagaggag gggaacacta 32220



agtcattgtg tgttggggca gtgcactgat ggtgtcacca tggtgaggtg tggtttctta 32280



ccagggtgaa caaaagaaaa tcaacaaaat cgagtatgaa aacaagcaac tgtgtcagaa 32340



aatcgcaaat gcccatcgcg gccctgccaa ggtggattgc tggaatgaat atttttccaa 32400



gaggtaatgt tctttgtctt catttcagtt ttgaaaagtc aaaattgact ttcctcttgg 32460



gttttagtgt gaggttttcc caagtcagag aagtacttaa gggaagttat cttgagggag 32520



aaccaaacag accatgttac acagaatgaa aactttaaaa atggggacct ttctctagca 32580



ttaaagagct tttatttcat cgaagagact tttcagagtc ctattcagtg tgtcacaaga 32640



atgcactgcg cacttttata aaatggtggc catgtgtctt agtccattat agggcgctat 32700



agcaaattgc tataaactgg tggcttataa acaacaaaaa tttctcatag ttctagaggc 32760



aaggaagtcc aaagatcaag gtgccagtaa attcggcatc tgaggagggc ctgcttcata 32820



gacaaccatc ttttcactgt aacctcacgg ggcagaagga gaaagaggct tctttcataa 32880



ggacactaat tccattaggg tgacctaatc agctctcaaa ggcccacccc ctaataccat 32940



caccttcatg gttaggattt gaacataaga attttggggg acacaggcat ctgttccata 33000



gcaccatggc tggggctatg atgtgacatt cttaaaatca gttccagaaa tctttcctga 33060



gcaactacta tgtgctaggt accaggaata ataaagatga aatgagatgt atatttcctt 33120



acctcaaaga actcaaggtc ttgtagggga gatatttatg gaaataatga caatgcagtg 33180



tgattaggga tacaaaagaa gctcatgcaa gagaaagaat ttgctggggg cgaggagatg 33240



gtcaagatgc cattctatat cctggtatat tctggtataa gttgaaagct gagaggagtg 33300



aggtgaccca aaacttgtcg ccagccgttt gtgatttatt cacagggaga ccttccccca 33360



accagaagtt ctcaatcctg gttttacatt ataatccttg gggaatttta agaaaatgcc 33420



agtgtgcacg gttcacctca gatcaatgaa gtagaatctt ctcatgggca acagggttga 33480



ggaccactga tataaacctg cgaatgcggt gcatgtttcc cggagtgcag tgcagaccaa 33540



caggctgtcc caggggcctg tgggctcagc aggacagttt actccctgca cttagacagt 33600



ctggcattta tgatctcatg acttcatctc ccccactcgt caagatgagc atttccttct 33660



tcacccattt cggggttttg tgtttttcag cttaaacaga gaaacaagga accgcgagct 33720



agtgagaatc accatggaaa accagggcat tctgaagagg cttgttgatc gcaaacccca 33780



ctatgaccgc agggcatctg agatagactg gcaggcacgt gggcactcat gttatactcc 33840



cagacacaca cagagtttgt cggtgttcag cctagagaga gtctcagaaa aatccctgaa 33900



cagctagagt cagatcacat gaaatgtaac aatcgttaaa agaaaaacca tccaaagcaa 33960



acaaagctaa caggcacaaa ccatcaaaca aacagctaaa acagcttggt agcaaagcca 34020



ttatgtgtca gtttcataac ataacaatta tgtgtcagtt tcagaaaaat aatctagtag 34080



cgtcttccct caccccttaa ttcattaaga aaggctgaat gtacagggat gaagggtata 34140



agattcagtc agtatgcggt tggtttgctt catttaggaa tgacccttaa aaaggccagg 34200



ggaggggaaa ccatctgtgg tgttttaaaa aacctccact taccgacttt ggtctttaaa 34260



tcttttctaa gtcatccctg ggatttagaa cttcagtaat agcaccaatg ccctggcatt 34320



gacataaacc aatttttttc cttcaagaat tcaaggcgct atatcagaaa taccacgaga 34380



tatcttctct cccaaaatga ataggtatgt ctctcttact atcaaacact gtgaccacag 34440



ctgataccaa agccctgaga accccataaa tggcgaatga ggggcccagt taaggagacg 34500



gattttgctc ttctcatata atattgacta gtcttccatt cgggaaactt ggggctctct 34560



gactttattt cttctctcca tacaagaagg aaatgacatt gtcttttgtc atcatctttg 34620



aggctttgtg ggagtctgag gggaagtgat ttgttccaat aagacataaa ctggaagacc 34680



tgtggcttta aaattgtgcc aaagttacat tccaggtctc tgtcagtatt caaaagtacc 34740



agcatgttgt cattttgtat tatttaacat tattagtgat gactaagtgg tttcccccac 34800



ccaagggaga aagataaatg gacacttagg cgttccaaag aatagttctg tataattgat 34860



gtgtctcctt ctctcttctc cactgaatac aaggttactc accatggaaa agatacaaga 34920



gaaggcccta ggatttcttg gctgctcagg atctcaagac actcccgact ggctgaatgc 34980



tccatcttca gatgcttcaa taaagcttgg aacataaaat gcgtaagtta catttagggg 35040



acccaaaggc tttatgttct cattccaaaa tggggcaggc agaaggaaag atgcaatgag 35100



catttttatt tggggctatg aaaagaagtt ttaacgagag agagagagag aaatctgaga 35160



gaactcttta aaacatacac catcatcacc atcccgtgga agaagaaaag ctggggtgag 35220



atcatccagc cacaagtaca gcactgtcaa aatggaaaac gaaatcacat gacaacatca 35280



aggttcagaa aacacaagga acaaatgcca ttagttcctc tgtgaataca cacgatcgga 35340



aaagaatgcc tcattgaagt ttccatggac tctgttcatt tatagggagc agcagcagtg 35400



aaaatgtctc aaaacatacg gtgagacaat gttgcaggcc tgctatgatt ggtcatgcta 35460



gttttcagcc caactatatt agtcagcatt tgccaaagag acagactcaa taggagagag 35520



agagagagag agagagtgag agagatagat agagagtgag agagagagag aaagagagag 35580



agagaggaga ggatttattt ggggaattgg ctcacaagat catggaagct aaagaagtcc 35640



caccacaggc catctgcaag ctggagaccc tggtggagca gggcagacaa cccccaaagt 35700



ggggcttagc ctgcgagtgt tcttggcttc acccaggaaa gaatttaagg gtgagccagt 35760



ggtagggtag aagaagacag ttttattgaa gcagcagtgt tacagctcca tgactgctcc 35820



tgcagtacag ggctacccca aaggcagaga gttttgcagt catagttata cgtactttta 35880



attacatgta gattaagggg cggtttgtgc agaaattcta gggaaggagt agtaattttt 35940



tttttttttt ttgagatgaa atctcactct gtcgcccagg ctggagtgca gatggcgcga 36000



tctcagctca ctgcaacctc cgcctcctgg gttcaagcga ttctcctgcc tcagcctccc 36060



aagtagctga gactacaggc actcgccacc acgcccagct aatttttgta tttttagtag 36120



agacgaggtt tcaccatctt ggccaggctg gtcttgaact cctgacctcg tgatccgccc 36180



gcctcggcct ctcaaagtgc tgggattaca ggcgtgagcc accatgtccg gcctatagga 36240



aagggtagta atttttgggt ccttgggtca ttgccctgga aaggggtggt aactcctagg 36300



tgttgctacg gtaatggtaa actgacatgg cacactagtg ggagtgtctt atggaaagct 36360



gcttccaccc ctttcctgtt ttagctagtc ctcaattgga tcctgtgtcc aagccccgcc 36420



tctggagtca aggcctgcct cccacctcac tgggatgctg gtagcatggc ttggtccaag 36480



cccaaaaacc tcagaaccaa gaagaaggtg gtgtaactct cagttcgagg ccaaaggctg 36540



agaacccact aggggggaca agggtgctgg tgtgagtctt ggagtacaaa ggccaaggag 36600



cctagagttg ttgtcccagg acaggagagg aagagtgtat tccagttcca gcagatagat 36660



tgacatattc gcctcttgtc tgtttttgtt ctttctgaat ccacagcaag ttggatgatg 36720



cctctccaca ttgagagtgg atcttcccac atagttcact cagacttaca tgctaatctc 36780



ccctggaaac actcacagac acacccaaaa ataatgcttt accaggtttc tattcagtca 36840



agttggcacc ttaaattaac catcgcactg actttttaaa ctttctattt tgaaataatg 36900



aaaattcaca ggtagttgca cataaaggaa cagggaggcc tcctgcaccc tttacccagt 36960



ctccaccaat gttagcatct tgcgtaactg gagtacaata tcaaaaccag gaaactgaca 37020



ttggcatgat gcatggaacc tatgcaggtt tcatcagtta tacatgcact catttttgta 37080



catatatgta tagctctatg cggtttttgc cacatgtata gctttgtgta accacattcg 37140



agatacttaa aaccactatt atcaaaagac actcttattg ccaccctttt agccacagtc 37200



acctcagacc ctcaagccta actcttggca atcacaatct gttttccacc tctctgttag 37260



ttcatggtat tacgtaaatg gcgtcatgca atgtatgttc atccttttga gattggcttt 37320



tttcactcag gataatttcc ttgatgttca tccaagttgt gtgtgccttt ttattgctga 37380



gtagtattcc atggtatgga catgctacaa tatatttaac catacatcca tcaaaggaca 37440



ttggggtagt ttctagtttt tcaaacatta ttattattat tattattatt attttgagat 37500



ggagtctcat tctgttgccc aggctggagt gcagtggcac gatcttggct cactgcaacc 37560



tccacctctg gggttcaagc gattctcctg cctcagcctc ctgagtagct gggattacaa 37620



gcatgcatca ccaggcccgg ctaattttta tatttttagt agagacaggg tttcaccatg 37680



ttgacccggc tggtctcaaa ttcctgacct caggtgatcc acctgcctcg gcctcccaaa 37740



gtgctgggat tacagacatg agccaccaca cctggcctga ttttttaaat agcaaatttt 37800



gaaagttatt tacatattat aggaataagt cctttgcctg ctatgcgcct tgcatgtatt 37860



tttctcccag tctataattt gtcttttcat cctcagggtc tttgacagag taaaatattt 37920



ttatttggat gacatccaat atatcaatga tgaaactgtt ctatatcttg actctatcaa 37980



tgtcaatatc cttgttgtga tactgtacca tatagttttg cactatgcta ccactggggg 38040



aatctggtaa ggagtttaca ggatctctct gtattatttc ctacatgcat gtgaatatac 38100



aattatctca aaataaaaag cttaaaaaaa acaacatgcc taaatacaaa ttcattatta 38160



actggttcca gttaatctca gtttgaggaa caaccattct tctagacacc caggttaaaa 38220



acctgaggtc atcttttact tcattccttc tctttcctcc tatccccctc cctacatatc 38280



tttttttggt tttttgtttg tttgtttgtt taaagacaga gtcactctct tgcccaggct 38340



atggtctatg gaggtgatct taaagctaca agtcttatgt ctcaatctct gtatgagcta 38400



ctgccatatt tcaggcactt gtgatttgca acttgcatta ctaatgcaaa aatacgccca 38460



tatcactttc tagcttaatg gcttccgtga tttgccattc ttgcataatg ggctggagct 38520



ttatatagag catacaaggc ttttcatgat ccagcccatg aactgctcag gttatattag 38580



ttatagtttc aaatgtttgg agattttcca gttatctttc tgttattaat ttttaatttg 38640



atcccattat gtccagagaa tatactctat catttcaatt cttttaaatt tgttaaggtt 38700



tttttaaatc aaggtgaata ttttatggac atttgaaaag aatgtgtatt gcactgttat 38760



tgggcaaagt gttctataaa tatgttaggt cccgttggtt gatggtgttc agttcttcta 38820



catcctgatg attttctctc tagtagttct atcagttgct aagggtgggg tgttgaaatc 38880



cccaactcta attgtggatt tgtctatttc tctttttaac tctgtttttg cttcatatat 38940



tttgaagctc tggtgtttgg cacatacaca ttaaagattg ctatatattt ttggtggatt 39000



gatttattga tttttttttt ttttttgaga cagggtctca ctctgtcacc caggctggag 39060



tgcagcacac tgctgagtgt gatctcagtt cactgcaact tccatctcct aggctcaagc 39120



aatcctccca cctcagtctc ccaagtggct gggactatag gcacgcacca ctgtgcccag 39180



ctgatttttg tatttttttt agtagagatg gggtttcatc atattgccca ggctggtctc 39240



gaattcctgg gctcaagcga tccgcccacg ttggcctccc aaagtactga gattacagaa 39300



gtgagatctc tttattatta tataatgtcc ctctttgtcc ctagtaattt tctttctctg 39360



aacttacttt atctgatatt aacatactca gtactgcttt cttaaaatta gtgtttgcat 39420



gatgtattac cttttatcct ttcactttca gcctacctgt ctcattatgt ttgaaggaac 39480



atatacttgc agacagcaga tacagacagt ctctgactta caatggtttg acttaaatga 39540



tttttttttt ttttttgaga cggagtctcg ctctgtcgcc caggctggag tgcagtggcg 39600



caatctcggc tcactgcaag ctccgcctcc cgggttcacg ccattctcct gcctcagcct 39660



cccgagtagc tgggactata ggcgcccgcc accatgccca gctaattttt tgtagtttta 39720



gtagagacgg ggtttcacta tgttagccag gatggtctct atctcctgac ctcgtgatct 39780



gcccacctcg gcctcccaaa gtgctgggat tagaggcgtg agtcaccgcg cccggcatga 39840



tttttttttt tttaacctta tgatggttca aaagcaatat acattcagta gaaatcatac 39900



tttaagtacc catacaacca tttctattgt tcactttcag taccgtattc aacagataac 39960



atgacatatt caatacttta tcataaaata ggctttatgt taggtaattt tgcccaacta 40020



taggctaatg taagtgttct gagcacattt aagttaggcc tggctaagct ataatgtttg 40080



acaggttaga tgtattaaat gtatttttga ctttgaatgt ttttcaactt accatggatt 40140



tattgggaac ataacctcat cataagtcaa gaagcatctg tacgtctgtt tttatgtatt 40200



gtgttgtttc tttctttccc tccctccttg ttcccttccc ttctctcctc ctcctcttcc 40260



ccctcccatt ccctcctctc ccctcccctc cccttccctt cccttccttc taccttcttt 40320



ccctttctta ggtcccagcc tccttctgtt aatttatttc tgtatggaga gcttccttta 40380



gccattcttt aagggtaggt ctcaacaaac tgtttctctt catctgagaa tgtcttcatt 40440



tttcccttta ttcctgaagg ccaatttcac ctgataacag gattcaaggt tgacggtttt 40500



gttttcagca cttgataagt gttggaccac ttctagatgg cccccatcat ttcttttaca 40560



ggtagtgcaa aaatacagtt tgaattagca ttccttcctg gttgtttctc cctgactgtt 40620



ttaaagattt cttttttctt aatctccagt ttttagaagg ttaattatga tgtgtcagta 40680



tggctttgga ctgttttctc tatttggagc tcaatcaact tcttgaatct gtaggtgttt 40740



gtcttccacc ggatttggga agttttcagc cattatttct ccgaatacgt tttagtctca 40800



cactttctcc tctcctgcaa agactctgat gatacaaatg tcagtagctc tatcacagga 40860



tccttagggt gtcacttcac cagccagaaa cctctgtggc tagtggcatc ttctgcctga 40920



gtattgcttg tgcccgctgg gcttgttctg cccactcagc ccagcaggct gcgctcagct 40980



cacactacag gcccagatcc cacacttgcc aggggtgagc caggcatgga gtggcaaggc 41040



gtgtgtgggc aagtgagcgc agggtctggc cactatgcac agccaggcat gctggctgct 41100



gtggtggggt ggggagctca ggtgctggca caggtgccag ctccatgcaa ggctgtggct 41160



ggaccagatg tactgcacac ggcttccact gcaggcatcc acgcctggat gaggggaacg 41220



cagtggcacc cggaagcttg gagacgccag aaatcgcaga gcccgaaaga gggtgtcaca 41280



gccctagctc agggagctgc agctcttctc tccttgtcac ccacaacatg gagagtgggg 41340



gtggcggcag gggggtgttt cagccctatt tgtgttacgg ctcttttagc cctgccattt 41400



gaagaggagg aaaaaatgat tctataccgt cttgttctga aaccataagc ctgatgttta 41460



aaggaagtag tggttggtgg ctgtattcaa agggcaggaa aaatggagta agaaactgat 41520



cagtggctgg gcactgtggc ccatacctgt aatcccagca ctttgggagg ccaaggcagg 41580



tggattgctt gaggtcagga gttcaagacc agcctgacca acatggtgaa accccgtctg 41640



tactaaaaat aaaaaaaatt agccaggcat ggtggtgggt gcctgtagtc ctagctactc 41700



aggaggctga ggcaggagaa tcgcttgaac ctgggaggca gaggttgcag tcagacgaaa 41760



tcatgccatt gcactctagc ctgggcgaca gacactccgt ctcaaaaaaa tagaaagaaa 41820



gaaagaaaga aatcgatcaa tattaactcc accaaataga gaaatgctgc tcattggttc 41880



ttaactatct gattaaaaat gggctttgtg catatgctga actctgcagt tattaaagaa 41940



atcatgaagt gttattgttt ggatgcatag tcctgtgatt ggtagcataa atgatgtgat 42000



actgggtaag tggatacaaa atttgattgg ccacatgttt taaagcatgt atttgaacat 42060



acaattggct aatatatctg agcactgcct gtaaatgaca gatggttcta actttcttga 42120



acccatcttc cacagggagt gaagtggata gcagggaagg ttacaaatca gtggattgag 42180



aatggcaaac aggaataact cactactgat tctgcccagc tgctactgaa cactgtcctg 42240



aaagagccaa agacattact aattgatcac agcactctcc tgttgagttt agttgatcac 42300



aataagagtg ctgtgatcac aataagagag tgctgtgatc aattagtaat gtcttccacc 42360



ggttcaggaa tgggcgttgg ctgcacatat gccacctatt taacacttcc gacctagaaa 42420



attcctctag agagcacatc ctctctggct gtagatacag gcagccaact tatctgtttg 42480



aagacccaag gattaaaaaa ggtccatctt gaggggtttg taataaggag atttattagt 42540



gttgggccca gagtaatgga tggagttttt ccaacatttt gcccaggggc tcagaacata 42600



tggactgcta gttgagatgg ggcttggaat tacatttaca cacattccac caataaatat 42660



ttgaacacag gtgcattttt taacaatagt tttctgcatg aactgcaaaa atgccttcca 42720



aatgacctct gtctctgggg tcctaccctt cctactccca taaatctggt agccaacaaa 42780



cagctgtaga cacagcttgt cttggggatt aggggctgcc ttgacaggaa ataaagcaag 42840



gatcactttt tttttttttt tgagacaggg tctcactttg ttgctcaggc tggagtgcag 42900



tggtgcaatc agagatcact gcagcctcca tctacctggg ctcaagcaat tctcccacct 42960



cagcttcccg agtagctggg accacagggg cacaccacca tgaccagcta attttttttt 43020



ttatacttta agttctaggg tacatgtgca caacgtggag gtttgttaca aaggtataca 43080



tgtgtcatgt tggtgtgctg cacccgttaa ctcgtcattt acattaggta tatctcctaa 43140



tgctatccct cctccctccc cccaccccac gacaggccct ggtgtgtgat gttccccacc 43200



ctgtgtccaa gtgttctcat tgttcaattc ccacctatga gtgagaacat gcagtgtttg 43260



gttttctgtc cttgcgatag tttgctcaga atgatggttt ccagcttcat ccatttccct 43320



acaaaggata tgaactcatc cttttttacg gctgcatagt attccatggt gtaaatgtgt 43380



cacattttct taatccagtc tatcattgat ggacatttgg gttgttccaa gtctttgcta 43440



ctgtgaatag tgccgcaata aacatatgtg tgcatgtgtc tttataccag catgatttat 43500



aatcctttgg gtacatgccc agtgatggga tggctgggta aaatggtatt tctagttcta 43560



gatccttgag gaatcgccac actgtcttcc acaatggtgg aactagttta cagtcccacc 43620



aacagtgtaa aagtgttcct atttctccac atcctctcca gcacctgttg ttttctgact 43680



ttttaatgat cgccattcta actggtgtga gatggtatct catagtggtt ttgatgtgca 43740



tttctctgat ggccagtgat ggtgagcatt ttttcatgtg tctgttggct gcataaatgt 43800



cttcttctga gaagtgtctg tttatatcct ttgcccactt tttgatgggg ctgtttgatt 43860



tttgcttgta aatttaagtt ctttgtagat tttggatatt agcccattgt cagatgagta 43920



gattgcaaaa attttctccc attctgtagg ttgcctgttc actctgacgg tagtttcttt 43980



tgctgtgcag aagctcttta gtttaattag atcccatttg tcaattttgg cttttgttgc 44040



cattgctttt ggtgttttag tcatgaagtc ctcgcccgtg cctatggcct gaatggtatt 44100



gcctaggttt tcttctgggg tttttatcgt tttaagtcta acatttaagt ctttaatcca 44160



tcttcaatta atttttgtgt aagatataag gaagggatcc agtttcagct ttctacatat 44220



ggctagccag ttttcccagc accatttatt aaatagggaa tcatttcccc atttcttgtt 44280



tttgtcaggt ttctcaaaga tcagatggtt ttaggtgtgt gatattattt ccgggggctc 44340



tattctgttc cattggtcta tatctctgtt ttggtaccag taccattttg ttttggttac 44400



tgtaggcttg tagtatagtt tgaagtcagg tagcatgatg cctccagttt tgttcttttg 44460



gcttaggatt gtcttggcaa tgcgggctct tttttggttc catatgaact ttaaagtagt 44520



tttttccaat tctgtgaaga aagtcattgg tagcttgatg gggatggcat tgaatctata 44580



aattaccttg ggcagtatgg ccattttcac aatattgatt cttcctatcc atgagcatgg 44640



aatgttcttc catttgtttg tgtcctcttt tatttcgttg agcagtggtt tgtagttctc 44700



cttgaagagg tccttcacat cccttgtaag ttggattcct aggtatttta ttctctttga 44760



agcaattgtg aatgggagtt cactcatgat ttggctcttt gtttgtctgt tattggtgta 44820



taggaatgct tgcgattttt gcacattgat tttgtatcct gagactttgc tgaagttgct 44880



tatcagctta aggagatttt gggctgagat gatggggttt tctacatata caatcatgtt 44940



atctgcaaac agggacaatt tgacttcgtc ttttcctaat tgaataccct ctatttcttt 45000



ctcttgcctg actgccctgg ccagaacttc caacactacg ttgaatagga atagtgagag 45060



agagcatccc tgtcttgtgc cagttttcaa agggaatgct tccagttttt gcccattcag 45120



tatgatactg gctgtgggtt tatcatatat agctcttatt attttgagat acgtcccatc 45180



aatacctagt ttattgagag tttttagcat gaagggctgt tgaattttgt cgaaggcctt 45240



ttctgcatct attgagataa tcatgtggtt tttgtctttg gttctgttta tatgatggat 45300



tacgtttatt gatttgcata ggttgaacca gccttgcatc ccagagatga agccaacttg 45360



atcatgatag gtaagctttt tgatgtgctg ctggatttgg tttgccggta ttttattgag 45420



gatttttgca tcaatgttca tcagggatat tggtctaaaa ttctcttttt ttgtcgtgtc 45480



tctgtcaggc tttgatatca ggatgttggc ctcataaaat gaattaggga ggattctctc 45540



tttttctatt gattggaata gtttcagaag gaacggtacc agctcctctt tgtacctctg 45600



gtagaattcg gctgtgaatc tgtctggtcc tggacttttt ttggttggta ggctattaat 45660



tattgcctca atttcagaac ttgttattgg tctattcagg gattcaactt cttcctgttt 45720



tagtcttggg agggtgtatg tgtccaggaa tttatccatt tcttctaggt cttctagttt 45780



atttgcatag aggtgtttat agtattctct gatggtagtt tgtatttctg tgggatcagt 45840



ggtgatatcc cctttatcat tttttattgc gtctatttga ttcttctctc ttttcttcat 45900



tagtcttgct agcggtctat caattttgtt gatcttttca aaaaaccagc tcctggattc 45960



attgattttt tgaagggttt tttgtgtctc tatctccttc aattctgctc tgatcttagt 46020



tatctcttgc cttctgctag cttttgaatg tgtttgctct tgcttctcta gttcttttaa 46080



ttgtgatgtt agggtgtcaa ttttagatct ttcctgcttt ctcttgtggg catttagtgc 46140



tataaatttc cctctacaca ctgctttaaa tgtgtcccag agattctggt atgttgtgtc 46200



tttgttctca ttggtttcaa agaacatctt tatttctgcc ttcatttcgt tatgtaccca 46260



gtagtcattc aggatcaggt tgttcagttt ccatgtagtt gagcagtttt gagagagttt 46320



cttaatcctg agttctagtt tgattgcact gtggtctgag agacagtttg ttataatttc 46380



tgttctttta catttgctga ggagtgcttt acttccaact atgtggtcaa ttttggaata 46440



ggtgtgatgt gctgctgaga agaatgtata ttctgttgat ttagggtgca gagttctgta 46500



gatgtctatt aggtccgctt ggtgcagagc tgagttcaat tcctggatat ccttgttaac 46560



ttttttgtct cattgatctg tctaatgttg acagtggggg gttaaagtct cccattatta 46620



ttgtgtggga gtctaagtct ctttgtaggt ctctaaggac ttgctttatg aatctgggtg 46680



ctcctgtact gggagcatat atatttagga tagttagctc ttcttgttga tcactttacc 46740



attacgtaat ggcctttttt gtctcttttg atctttgttg gtttaaagtc tattttatca 46800



gagactagaa ttgcaacccc cgcttttttt ttgttttcca tttgcttggt agatcttcct 46860



ccatcccttt attttgagcc tatgtgtgtc tctgcacgtg agatgggtct cctgaataca 46920



gcacactgat gggttttgac tctatccaat ttgccagtct gtgtctttta attggagcat 46980



ttagcccatt tacttttaag gttaatattg ttatgtgtga atttgatcct gtcatcatga 47040



tgttagctgg ttattttgct cgttagttga tgcagtttct tcctagcatt gatggtcttt 47100



acaatttggc atgtttttgc agtggctggt accagttgtt cctttccagg tttagtgctt 47160



ccttcaggag ctcttgtaag gcaggcctgg tgatgacaaa atctcttagc atttgtttgt 47220



ctgtaaagga ttttatttct ccttcactta tgaagtttag tttggctgga tatgaaattc 47280



tgggttgaaa attctttcct ttaagaatgt tgaatattgg ctcccactct cttctggctt 47340



gtagagtttc tgccaagaga tccgctgtta gtctgatggg cttccctttg tgggtaaccc 47400



aacctttctc tctggctgcc cttaacattt tctccttcat ttcaactttg gtgaatctga 47460



taattatgtg tcttggggtt gctcttctcg aggagtatct ttgtggcatt ctctgtattt 47520



cctgaatttg aatgttggcc tgccttgctc gattggggaa gttctcccgc ataatatcct 47580



gaagagtgtt ttccaacttg gttccattct ccccatcact ttcgggtaca ccaatcagac 47640



gtaggtttgg tcttttcaca tagtcccata tttcttggag gctttgttca tttcttttta 47700



ctcttttttc tctaaacttc ttttctcgct tcatttcctt catttgatct tcaatcactg 47760



ataccctttc tcccacttga tcaaatcagc tactgaagct tgtgcatgcg tcatgtagtt 47820



ctcatgccat ggttttcagc tccatcaggt catttaagga cttctctaca ctgtttattc 47880



tagttaccca ttcgtctaat cttttttcaa ggtttttagc tgctttgcga tgggtttgaa 47940



catcctcctt tagctcggag aagtctgtta ttaccgatca tctgaagcct tcttctctca 48000



actcatcgaa gtcattctct gtccagcttt gttccattgc tggcgaggag ctgcattcct 48060



ttggaggaga agaggcgctc tgatttttag aattttcagc ttttctgctc tggtttctcc 48120



ccatctttgt ggttttatct acctttggtc tttgatgatg gtgacgtaca ggtggggttt 48180



tggtgtggat gtcctttctg tttcttagtt ttccttctaa cagtcaggac cctcagctgc 48240



aggtctgttg gagtttgctg gaggtccact ccagaccctg tttgcctggg tatcaccagc 48300



ggaggctgca gaacagcaaa tattgcagaa cagcaaatga tgccatctga tccttcttct 48360



ggaagctttg tctcagaggg gcacccagct gtatgaggtg tcagtcggcc cctactggga 48420



ggtgtctccc agttaggcta ctcgggggtc agggacccac ttgaggaggc agtctgtccg 48480



ttctcagatc tcaaactcca tgctgggaga agcactactc tcttcaaagc tgtcagacag 48540



ggacgtttaa gtctgcagaa gtttctgctg ccttttgttc agctatgccc tgcccctgga 48600



ggtggagtct acagaggcag gcaggcctcc ttgagctgca gtgggctcca cccagttcca 48660



gcttccaggc tgctttgttt acctactcaa gcctcagcaa ttgtggacgc ccctccccca 48720



gcctcgctgc tgccttgcag ttctatctca gactgctgtg ctagcagtga gcgaggctca 48780



atgggcatgg gaccctctga gccaggcacg ggatataaac tcctggtgtg ccgtttgcta 48840



aggctgttgg aaaagtgcag tattagggtg ggagtgtccc gattttccag gtaccgtctg 48900



tcacggcttc cctttgctag gaaagggaat tccctgacct cttgcacttc cagggtgagg 48960



tgacgccctg ccctgctcca tgggctgcag ccactgtctg acaagcccca gtgagatgaa 49020



cctggtagct cagctggaaa tgcagaaatc acccatcttc tgcatcgctc atgctggcag 49080



ctgcagactg gagctattcc tatttggcca tcttggaacc taccccccca actaattttt 49140



aaatttttat tttattgttt ttatttattt aagacacagt cttgctctgt tgcccaggct 49200



ggagtgcagt ggcatgatct tggttcactg caacctctgc ctcccaggtt caagcaattc 49260



ttgtgcctca gcctctcgag tagctgggat tataggcgtg tgccaccatg cctggctaat 49320



ttttgtattt ttagtagaga cagggtttca ccatattggc cagactggtc tcaaactcct 49380



ggcctcaagt gatctgccta cttcagcctc ccaaagtgct gggattacaa gcgtgagcca 49440



atgctgctgg ctctaatttt atgtttaata gagacaaggt cttgctatgt tgcccaggct 49500



ggtcttgaac tcctgagccc aagtgatcct cctgcctcgg cctcccaaag tgctgggatt 49560



acaggcgtga gtcaccacac ttggctaagg atcacttttt aatactctgc ttcataatac 49620



atgtaaagag aattaccatc atttaatctg acaattgtgt aaaaatatta tgtaagcagc 49680



agaaaatgcc tgtggagtgg tataaaatgc agaaagaaca tcattgggtg cccaaccact 49740



gtgttcccac actggaggga aaaccaccta catggggctt tgagacttga ttaggatgtc 49800



caccatgatg cctcctgagg ggatcttcaa aagtaatttt taacgtatgt gggtttgttt 49860



tgcttttgcc tgtgagcaga cttcagatcc cagctctcct gcataacaac tttttttttg 49920



agacagagtc tcatttgtca cccaggctgg agtgcagtgg cacggtctcg gctcactgca 49980



acctctgcct cccaggttta agtgattctc ctgcctcagc ctcccaagta gctgggatta 50040



caggcacccg ccaccatgcc cagctaattt tttttttttt tttttttttt tttttagtag 50100



agacggggtt tcaccatttt ggccaggctg gtctcaaact cctgacctca agtgatccac 50160



tgcctcagcc tcccaaagtg ctaggattac aggcattatc ctgcataaca actttgcatg 50220



tgctggtcac acttcagggg cagctgccct ccctggcctg gctctctgta gatcagctca 50280



agaccaattt cacttgataa gaatccaata ctctctaagt gtaaagaagt ccccatcttt 50340



ttactagaaa gttctgaaga atgtgatcct gttacgtgga cctaccagtt catgagctag 50400



agcgttgcaa aggtatcctt gtgtagaagg taaaatggaa atttctaaat gggtggcaaa 50460



ccttctccct ggtgcttcac cttcaacttg gcctcctttt cctttcatga gtaaaagaag 50520



ttgaaaatgt acacgtgtat gtagcctctt ttcagtctta gaagttatgg tcacacttca 50580



tattataaat tctagctgta aacacattca tcatttataa gtgaattata ttagtgagta 50640



gcctcgatta tgggaccaca aaagaatgag gcagtatagt atagtggtta acgatcatct 50700



ctggtatttg ggcgatttag gctcaaatac catagctctg cattttttaa tttttaaaat 50760



tttttgaggc agggtctcac tctgtcaccc aggctggagt gcagtggtgt aatcatggct 50820



cactgcagcc tcaacctcct cgttcatccc acctcagcct cctgagtagc tgggactaca 50880



agaacacacc accatgcccg gctagttttt gtattttttg tagaaatggg gttttgacac 50940



attgcccaga ctggtctcga actcctgaac tcaagcaatc cacccacctt ggcctcccaa 51000



agtgctagga ttataggcat gcactacagt gcctggcctg caattttttt tttaaatctg 51060



tgcaagcttg ggcacattat ttaaactgtc taagctttat tttttttctc gtttgtacaa 51120



tgagatgata agaatcctac cttattggct tggtgtattt atcagggtaa tgtatgtaaa 51180



ggccttagca tagcatccag cacagaataa agactgttgc tggctattaa taataaaaaa 51240



aaattctctg agcacctaag atatatcatg aatcctgggt gataatcatt tttgctcaga 51300



gacaacccat taggcccaca ctctgggtct acatactttt attcttgaca gaaatggttt 51360



acagtgacgt agccatagtt ttgacaggga gagtcatctg gtttcccaag atctagcaca 51420



atgggaaccc ctatgatctc atggcaggga ctggctagga ccaaggcaac tgtcagtaac 51480



aaaagggaca atggatggaa tagaacaaat caaacaaagc atgggctcga tgttaggaat 51540



ctgagggtat ttagaaaggg gaaaggcaac cttacattcc tcgagtccct gaaggcacca 51600



ctgcagtaca ggatagtaca gtaattcatg ttgatggtga agtgtgcctc agccttccag 51660



agaaaattta cgtatattca ctattttaaa ataggcagag aacccgtttt ctattaccag 51720



gcaagcactt caaaaaaaag gttaagatca acgttttagt gcttgaagac aggggaactt 51780



cagttacatg taaaatcccc ttggataaaa caagttagct tccaaaaaaa ctactaagcg 51840



tcactatgtt taaaaagctt aaacattctg cgaatcagta ctgtataaat taaccactac 51900



cacccacaaa agacagtggc tacttaactt tggtacaaag aatcagggtc agcttgcctg 51960



tgatacttta ataaatgaaa tgtgttgttt tctgatatgc ccctttcaaa tcatgatcca 52020



aagaggtgca gtgaaaaaca acagacaaaa accaacaaca aacaagactt cccacttata 52080



ctcttctcga tgatggaatt tgtggagaat tctctccctc tctgcgcttg agattccttg 52140



atggtaaaat gagggagtct ggactagatg atcttcaagg tcccgtccag cttggatgtt 52200



ctgggataaa gttacctgac ccaactaaca ggtacccagt gagtgtcctt gctcagcttc 52260



tctaagacca ctttgagctg gctgtaggca ccctggagat cctccttcac cagcacggcg 52320



tctaccaggt gcccgtaatg ccggtctatg aaggcggcag aagcggccat ctcttgctgc 52380



tgctcatcct gcaaggaaag gggtggtaaa aggagcaact gggttgttct cctataacaa 52440



acctataacc tttgtcttga gcaatgttcc aacctttaac ttttaagtga tgagtggatg 52500



actaggtccc actgataacc aactgtgtac acaagaacag agcataggga caacatcatg 52560



tcaaacttca aagaaagtta atgggcagta gacacaatca ctgttcagtc attcactcac 52620



agaatacctc ctgaggacct atgaactcaa agccacgata ggaagtgcat tggggatgct 52680



gattctataa ctgtgtatat atgctaatat cacacttcct gcctcagaag tacttccaaa 52740



gaagtagtag tattgtgccg catgacattc agtacacagg ttaaataatt ataagaaaga 52800



actataaata ataactatat aaaaacagag caaacatttc tgcaatcaac tggtggaaga 52860



aggagaagaa atcattctaa tgccctcctg aagactccta aattcacagt gcagaactca 52920



attcacttcc tcacaccaga gccaaacact agcacagcaa agtggagtta tttaagaaag 52980



cactggacaa ttctaatcaa attccccatt tccttagggc agctgatctc tttaatcaga 53040



ttgcttttct gacacttaac attaaggtat aggcaacaac tccatcttac acaatgtggg 53100



cactgtttgc atcttcattc aaaagaacct ctaataagta ttatttcaag tgagtagttg 53160



tctgacaatt agcctggttt tggaaaacag gaaagtggca ggcccattct aagtaaaatt 53220



acaaaataaa atttgtcgct ggcattcact cactgccctt tttagttctc tgttgctgtc 53280



tcccctctgc ttctaggggc tcagtgtttt catgctgcca cagggaaagg gtgagttctg 53340



ttctctccca aagagaccta cattccaaat attcccccct cttctctgtc accagtcaaa 53400



acccaattcc tacattagtg agagcatctg aaatttcagg attcgagtcc tcaagatcca 53460



ggaaaagggt ttggcatgct acttcaaaga tagtagaaat gtaagagaag gctgagataa 53520



tttcttctcc ttttctcctc caggagggaa aaaattcgat taaattggga gacacttctc 53580



aattctatat tctatataga atattcttgc agggctactt tcatactcag aagccctatc 53640



ccgtaactgc ccccggatct tcaaccccac cttccccact ccctgacaca cacccatcct 53700



atagacctgt ctgctgcttc cagtttcccc tcctccaggc acccacacgg ttcatcctgg 53760



aagcatttgg ctatttgaga aattacagaa ggaaaatttt tgccacaaag aaccacaatc 53820



tacctaataa atatctgcat ctggaaagaa cttaagtaaa tctctaatgg agtaaaaacg 53880



tgtgacattt gcttagcagt cataaatccc ctgaactcct ttcctggcct gtaacgatgg 53940



aactcgccca cctgtgtctt cagcaagagt cacagtcccg aagatcacat aggaaagatt 54000



cccctgtgct gtccgtcacc cccaggttgg atcagctttg ccgggtcaga agccagaagc 54060



cccattaact tgtggtcagc aaggaaacag aggatgtttt gggtccccta ccaggaactc 54120



aggtgccaga caatggacag atatttaaag ttacacaaaa cccatgcctt tgtgaggaat 54180



ttctccaaat gtcatctggg gtctgccaac atacatcaaa accacatgaa aggctgtgtg 54240



ttaaaaatgg agtgcctggg ccccactcca aaccccctag gtcggaatct ctgggagtag 54300



aaccggggac tctgtgttga acagcctcac tgtgaccctg ctgcctactc acagctgcag 54360



tgtggtggag catgaacggg ccagctgcat ttcatcatca gcccacctgc ttggaatgca 54420



gcattctggt gggcaataaa ggagatggga tagatgacaa aaccggccag gctggaagga 54480



cactgggaat agaatgcagc tgcttctctt gaaataacaa ccatgggcca gggagggttc 54540



tgaatcctag aaagctggca ctgcctgtgg acctgatgat ttggccttga gtcctaggaa 54600



gctgcctctt attctcccag tgacttcttg actctttgaa aaatgagcca tttccccctg 54660



cttattcaat cctgaaatat ttgcaaaaca aaacaaagcc aatatagtaa aacaaatggg 54720



cagattgatc ctaaaattca tatggaaatg taaaggaccc agaatagcca aaacaagctt 54780



gaaaaacctg acttcaaaac ttactacaaa gctagtaatc aaagtaagac agtgtggtgc 54840



tggcctaaga atagacatgt agaccaatgg aatgggactg agactccaga aagaaaccct 54900



tacttttctt gccaattgat tctagacaag ggtgttaaaa taattaaatg agaaaatagt 54960



cttttcaacc agtgatgctg gggtaactgg ctatccacat gcaaagaatg aagttggacc 55020



cctacttcag acaatccaca gaaaataaca caaaatagat gacagatcca aatgtaactg 55080



ctacaactat aaatatctta aaagaaaaca aaggagtaaa tctttatggc cttggattcg 55140



acaatgattt cttagatatg acaccaaaaa tataaatgac aaaagaaaaa atagatacat 55200



tggactttat cacattttaa aatgttatgc ctcaaaggat gctatcaaga aagtaaggac 55260



caggcgtggt gcctcccagc actttgggag gccgaggcag gtggatcacc caggtcagga 55320



gttcgagacc agcctggcca acgtggtaaa accccatctc tactaaaaat acgaaggaaa 55380



ttagccgagc atgatggcat gcgcctgtaa tcccagctac ttggaggttg aggcaggaga 55440



atcactcgaa cctgggagct ggaggttgca gtgagccaac accgcaccat tgcgctccag 55500



cctgggcaac aagaacgaaa ctctgtctca aaaaaaaaga aagtgaaaag acaactcaga 55560



atgggaaaaa atatttgcaa atcatgcatc tgacaaggga cttgtatcca aatagataaa 55620



gaattcttac aactcaataa caaaaaatgg acatttaaaa atggacaaag tatttgaaca 55680



gacatttctc caagaaagat ataaaaatgg ccaataaaca catgaaaaga tgctcaactt 55740



cactgatgat tagagaaatg caaattaaaa ccacaatgag ataccacttc acacctacta 55800



gtagtgctat gattaaaaag acagacaata acaagggctg gtgaggatgt ggagaaatgg 55860



gaactcttga acactgctgc tgggaatgta aaatggtaca gctgccatgg tagagttaaa 55920



catagaacta ccctatgacc cagcaattcc ataccaaggt atacacccaa gagaaatgaa 55980



aacatatgtt cacacaaaaa cttgtatatg aacattcata acatgattca taatagctga 56040



aaaggtagaa acaatctaaa tgtccattaa tcgataaatg ggtaaacaaa atgtggtact 56100



ctatacaatg gaatgttatt cagccataaa aaaagaatga agtattgata catgaatgaa 56160



ctttaaaaac attatattaa gtgaaaaaag ccagatacaa aaggtcttac attgcatgaa 56220



tccatttata tgaaatgttt agaatagaca aatttatagt gacagtagat tagcagttgc 56280



ctgtggctag gaaggggctg gaggaaaaca gataatggga aattctaatg ggctcaaggt 56340



ttctttttga agtgatgaaa atactcttaa attgactgtg gtagttgcaa caactctgtg 56400



aatacatcat tgaattgtat gctttaaatg tgtgaattgt acagtatgta aattttatct 56460



cagtaaagct gttaactccc cctccaaaaa acacacagaa aacaaaacaa aatttagtca 56520



tgagcccact attcagggag aattgccttt agcgttttag tgtattttgt gtgtaacaca 56580



aaattagaat cctgattttt tattttgatt tattttttct tgtatttagc tatgtcatca 56640



aatattcctc caacacatgg cttttattta tttatttaat taatttattt ttttgagaca 56700



gagtcttgct ctgtcgccca ggctgaagta cagtggtgca atctcagctc actgaaaact 56760



ctgcctccca ggttcaagtg attttcctgc ctcagcctcc cgagtagctg ggattacaga 56820



tgcctgccac cacgcccagc taatttttgt atttttagta gagacggggt ttcaccatgt 56880



tggccaggct gatctcgaac tcctgacctc tgatgatcca cccacctcag cctcccaaag 56940



tgctgggatt acaggcgtga gccaccactc ccggccccaa catatggctt ttaactggct 57000



ataatacttc aatacatcct gtaagtgtca cataatggag tatattgaac tgagtcctga 57060



cagtgaacat tatttaggtt gtctctgatt tttttgttat atgatgggca tactgtatgt 57120



ttcttttttt tgtttttgag atggagtttt gctcttgctg cccaggctat agtgcgatgg 57180



cgcaatctcg gctcattgca acctctgcct ccaagttcaa gcaattctcc tgcctcagcc 57240



tcccaaatag ctgggattac aggcgcgtgc caccacaccc agctaatttt ttgtatttag 57300



tagagatggg gtttcaccat gttggtcagg ttggtcttga actcctgacc tcaggtgatc 57360



cacccgcctt ggccctccaa agtgttggga ttacaggtgt gagccactgc acccagccaa 57420



tattgtatgt ttctaaatga ttctagactt aagttgatat tcccctattc cccttagagt 57480



ttcttgtgtc tttttttttt tagatggagt cttgctctgt cacccaggct agagtgcagt 57540



ggcgtgattt tggctcactg caggctctgc ctcctgggtt caagtgtttc tcctgtctca 57600



gcctcccgag tagctgggat tacaggcatg caccaccaca cctggctaat ttttgtattt 57660



ttagtatgag acggggtttc accatgttgg cctggctggt ctcgaattcc tgacgtcagg 57720



tgatctgcct gcctcagcct cccaaagtgc tgggattata ggcgtgagcc accatgccag 57780



cctccccctt agagtttcta aaggagaaaa tttttctttt ttctacattt tttttttttt 57840



gagacagagt ctcactgtgt catgcaggct ggaatgcagt ggcatggtca tggctcactg 57900



cagccttgac ctattaggct caagtgatcc tcccactccc acctcagtct cccgagtagc 57960



taggactata ggtttgtgcc accacacctg gctaattttt gtaatttttt tgtagagatg 58020



gggtttcacc aagttgccca ggctggtctt gaattcctgg gctcaagcaa tctgcccgcc 58080



tcagcctccc aaagtgctga gacacaggtg tgagccaccg tacctggcca aggagagaat 58140



ttctaatgtt ccttgtatgt atgccattct aaataattta ctgagaccag atacggtggc 58200



tcacacctgt aatcccaaca ctttgggaag ctgaggcagg aggatcattt gaggccagga 58260



gtttgagacc ggcctggcca acacagagac accctgtctc tataaaaaaa ttttttttaa 58320



ttggctgggc attgatggta catgcctgta gtctcagcta cctaggaagc tgaggaagga 58380



agactgcttg agcccaggag ttcaaggctg cagtgagcca tgattgtacc actgcactcc 58440



agtctgggca atacagcaag atcctgtccc caaaaaaata aaaggctggg cacagtggct 58500



tacacctgta atcccagcac tttgggaggc caaggtggga gaatcacttg agcccaggag 58560



ttcaagacca gcctggacaa catagtgagt ccctgtcttt aaaaaaataa taataaaata 58620



aaaagtgtat caacgtggac agttaaaact gagaattagt atgaactagg attgcatcaa 58680



aatcttgact cagcgggagc ttcctgacca aggggaagga tccgagaagg cctccttcag 58740



atgaaaccag ctatatagga cagcaagtaa agtctattct gggactgagt tgcttctgac 58800



tgcccccacc acccacaaca acttccaact cattctgcta actgaccctg ttaagaacca 58860



aaaaagatga gtcaccaagc ccacacctcc tggaagaact ctgtcaaata tttaggtttt 58920



gggtgagggt ctcgccatcc tgacatagac tgggctgaac aaagaatcta tgacagtgaa 58980



acagaagttc atttaggaca catcagacga tctcatccac tagttttaga aatcccttca 59040



ttcactgatg attcaaactg gtttgatagc agtgataatg accttgttag ttggggtttc 59100



aatttaaaat acttggattt ggcctaggag tatagtttga tgagtacagt ctgtcacact 59160



cagatgaggt ccctgacagg tgtcacattt tgcgggaggg cgcttatgtg agggagtgga 59220



ggggcgtgag cccaggcaaa gccacctgcc tggtttggga ggcacttcca gctgttcacc 59280



ttgagccttc tggccatgta atcatcttct cttaagtttt tcaataggca aaatggaaag 59340



acaatcacat gtagaaggtg tgtcccgcat ccctcttcag ctgcaagcac ccttatgcag 59400



ctagaagcgt tcctgtaaca gcctccctta ggccttcaga aaagaaacaa tcaactttaa 59460



acttacaaat ggggctgctg tgtcctcaca agctggggac ataggtggcg tttttctttt 59520



ttcctgaatt gcaggcttta caaatataat atagggttta aattctgagg tcctcagttg 59580



tttcagtgcc tgagaaagaa agttcaggaa tattatatac ttttgaagtg ttttgttgtg 59640



aaatagactt ttgaaagctc aataatcgtg tgcttcaata ccataacctc aacagcaaag 59700



gtcctggtta catgggtccc atgacaatgg acttcaactg ggcagaccaa ctgctccttt 59760



tctcatcctt cactttgacg ttgaactcag cggggccctg aagtcacact cactgccaac 59820



agaaggttcc taagcctcag ctcagagaca gttgctgtct ctcttagctc tgactcctcc 59880



ggctataatt aaccttctca ggctcctctc caccttccat ttctgatggg tgaggaagca 59940



ggagtcagtg tgtatctatt tagtcaaatg tcatcaatcg gactacatta ttacaaactt 60000



tgtgctatta catctcctct tggtattcaa agaagaaaag gtttgcaaag caaatgagat 60060



tactgaacag atcatttaaa actgtagact gtagaaactg cactcttggg ccaggtgcgg 60120



tggctcacac ctgtaatccc agcactttgg gaggccgagc cgggtggatc acgaggtcag 60180



gagatcaaga ccatcctggc taacatggtg aaaccccgtc tctactaaaa atacaaaaaa 60240



ttagccaggc gtggtggcgg gcacctgtag tcccagctac tcgggaggct gaggcaagag 60300



aatggcgtga acccgggagg cggagcttgc ggtgaaccaa gatcgcacca ctgcactcca 60360



gcctgggtga cagagcaaga atctgtctca aaaaaaaaga aaaagaaatt gtactcttga 60420



ttaatgcatt ttatctagaa gtaagggctc cacttggaaa cactagtatt aaactgctat 60480



atgcattatc tgcacccttg atcaataaag tgatcaataa aatcactttt caaagaaaat 60540



tttgaaactc agacttttaa ttttgatcac taactccctg taagtccaaa tgagtgtttt 60600



cctttatagg cataacgtgc tttttggaat atatttcaag caaacttctt taaaataaag 60660



cctacagttt atagcataaa atcagagatc tgtttctata gaggggaaaa aaaatcccca 60720



gattgagttc aaagcttgga agtttttcta aaagacaagg ttaaaaagat ggttaagccc 60780



ctgctgagtc cacagcatgc tgggtgtgca ggagtggaaa tgtttttgaa gcacttccca 60840



gggccgtgtc tccctccctc tttttcccct ttaaactgct ctcctcactg cctccctgag 60900



tggttctcta agccactgac tccacctgcc ctggttgggg agggggaggc ctggcaccga 60960



gagctcagcc ccagtttcac ctgggtactg acatctaatt ctctggcaca ttgcaatggc 61020



cagtcagcgc caccaactat tgcatgatct gttccacgca ggagttacta gcctgggtct 61080



gtgggccacc agagtgtcca caagctccct acaattaatg cagcatttgt ggatagaggg 61140



gcatgttttg gggtacaagg ctttcatttg attctcaaag gaagacccaa agaaattgaa 61200



cagccagtgt tctagactaa aaattcctta gactgaggtt aagtgttgtg taaaatgtac 61260



aatcccctag ttataaattc cgttaaccag aaatggccag caggcccagc aactcacttc 61320



tggctccaca tccaccaaac aaactttgtt tttggccata acagcctgaa tggcctccag 61380



gctggttcca tacagatttt ccttatattc accatgttcc aggaacctaa aacaccacca 61440



aaggggaaaa ggcctttagt tcctcagctt tcctaaatta gcaaagcaaa ggggacctcc 61500



caacatgact tctctcccgc ttcccccatc ctttccggga gtcctcccag gagctctagt 61560



ggaatacaga tacaaaaaca cacaactgcc tggagggcca actggcccat caagcaacgt 61620



acttgttgtg atgtaagtcg gcctcaaatg cttgcttaga cacaaagtga tattccactc 61680



cttccttctc atggctcttt cggggcctgg tggtatcttt taaagaaaga aggaaagctg 61740



ggcaaagaga tgtcacatca cagcacgcag ggacagcagc aggcttaggc actcatttgg 61800



gagttcactg ctgctgtgtc taaaccaggc acttccacct cattgcatgt ccctgtatca 61860



ggcactgtgc ctttccaggc aggcgtatca ctgattcaca caacaactct ttgatgtagg 61920



caaaaggagg cttttccttt tgcagctgag aaaactgagg cacggagagg ttcagcactg 61980



tgcacagtga cccacaacca gtagagagca cagccagaat cggtctctct gccaaatgcc 62040



cagcttatac ccttaaccac tctgctaact gactccctga tgctgtgttt tttttttgtt 62100



tgttttgttt tgttttttgt tttgagacgg agttttgctc gttccccagg ctacagcgca 62160



atggcatgat ttcggctcac tgcaacctct gccttctcgg ttcaagcgat tctcctgcct 62220



cagcctcccg agtagctgga attacaggca tgtaccacca cacccggcta attttgtatt 62280



tttagtagag atggggtttc tccatgttgg tcaggctggt ctcgaactcc cgacctcagg 62340



tgatccaccc gcctcagcct cccaaagtgc tgggattaca gacatgagcc accgcgccca 62400



gcatatgctg tggcttttaa agaatcactt aagggacccc tagtcctaac ttttaattct 62460



tcattgtttt ttattttttg agagcaaagg agccacacat acacttgacc ctgatgtatg 62520



cttttaattc tttagtcaat tagttctcat ctccagaaaa aggagacagg aagacagacc 62580



gtccctatat agatcggatg tgtttcagca aggctggctc tcaaacaaaa atgttgaaac 62640



acatggtgtt ttctcattga tttccataac agaattggga tgcacacttc tgaggaaaat 62700



caggtcttct gcagaacaag ggcacacaca aagccacaca cacagtattt tccaaaagat 62760



aaaatgggat cttgaggcac tgtgtcttct ggcccatggg aaccacccag ggtatgccct 62820



gtgttctttc tgtggcatct tagtccaacc tccggtagag gtgctagggt cacttttcca 62880



accatgtcat ccccctgctt aaaaacttgt atttatctat gggttacatt ctaaacaccc 62940



tagctgagta tctgagacct gcgtgatctg cccaacctct cagctccatt ttccagcaca 63000



ccatccacac taatctcccc ggtccccaac actgctccgt ccctttgcac atgttgtttc 63060



ctctgtaaag agaactattc ctttctcttc tgcctggaaa actcctattt actcttcaga 63120



acccagcata aaagtcactg cctctgggaa ggcttccctg actcccccag tttctaaaac 63180



aaaggaggaa agtctcctat ctgtggagtg cctagaagca ggtgggcctg accatccagg 63240



tacctcttct ccagggggtg gatccaaggg gttctgaacg atcagtgtgt gagcaacctc 63300



tgcatgtcct gtttcagtcc acctgaaact tggaaggccg tggctccctg aagccctcca 63360



ggtccatcac aggtgtgctg ccaggatggc ctccccaggg ccaccacctc ccccacatcc 63420



ctgccacttc agattgggct gtggaagaca gctctgacaa cccacagact agacgctggg 63480



cccaggggcc cagggagagc ggtgtgatca aagcaaggct tcatggttgc tctgccccag 63540



aacactctga ggaggcccca ttagggcccc cacagcaccc ctctcagtag ccaccaggca 63600



ttcacactgc atccctctga ggccaggggg actgagagtg agtcccagaa agaaaagggg 63660



cagccaaggg cacgaagtgg gaggcggcag gtgagaggcc attgtgcatc ctcgttaaga 63720



acatgactgg ggcaggctgc ctgggtatga atcctggctc caccacttac caactgtgtg 63780



acattggaca agttacttaa cctctctgac cctcactgtc ttcctctgcc acacaagatg 63840



ataacaatct ctcttctcag gggtactggg agggctgacg cagggcacta cacataaaag 63900



ctcttggtgc attacctggc accttcattc tcctcctcct catcctcctt atcacattca 63960



gaaccaggat cctctgccca ctggagcttg acatcccagg gtgcccctgg cagcagtaag 64020



ccccaggaat tggcagggga ggcatcaccc aggaatgtac ccagctaccc tgacaaactg 64080



gaatctggct ataagggagt gccgagaaat accactcaca gggctctgtg gcttctctga 64140



cctgccctct catccaagca gagggcagcg gccacaggag tcaaaattca ctgtgatgag 64200



gaggaatgcc ccctactgtg ggggccccgt ggtgtcaggt tgaggctgcc actttgccta 64260



caatgtgctc tggactcatc tcccacccca ggcaggaacc aagcaagtgg tcctccaact 64320



tctgcctcag agggtctcag aggaccactg ggagtggatt tcttcccatc atgcctttgt 64380



cccacaattt gccaatagca ggcagtgcct ggtgatcctt taaacccaaa gtaaggattt 64440



ggatggatct ggggagttaa gtctccatgg aatatttgtg tgtgtgcaga caaacacaca 64500



ctcccacatg ggccctctta cgtggaacag cgacgccaaa gtgctgtggg ttctcagcca 64560



ccaccttttg cttcagctcg tgcagtcggg ctcccagaga ccctgggaaa caagaagaag 64620



gctgaccagg gtccctgctg agctccctcc ccacctgctc cagggaggaa accagatcac 64680



ttcctggaaa cccaggatgg cacctaccga tcagaaccac caggcggggc cgctctccgg 64740



gctggtgttg gtacctggcc acctcttcgt aagtcagcag ctccggagac tcagctccgg 64800



aggacatctt tccttcctgc gagccaccca gtctctccct acagcccagc cggaagctcc 64860



tccgaagacc agcttgggag gaggggcaga gggacaccat ggcatttgtc ccagttgtcc 64920



caggatctcc cagtagagac ttttcccacc tggccagacc tggagatggg actgagtccc 64980



actgacttct cccaacctcc tcctgctact ggaagaggtt gttcaggaaa tacaataata 65040



agatgaaagg gtgacccctg cattcacaaa ctagggctta aggtcactgt tttacttggc 65100



atgtgactga ccttggacaa gtcccttcat ctctctgagc ctcaatttcc ttacctgtga 65160



aatgaagata tgaatctaca actactatgt gtggtcctag attagatcct ggaccaaggg 65220



aaaatgtcat aaaggacatg atggggacaa ttgttaacat ttaaataaca gcatataaca 65280



gatttggata cattttaaat tctcagaatt tgatcactgc cctgagaaag tccttggcct 65340



taggaaatac atgctgagag atttagggtt aaagggacac gatgtctaca actaagtctc 65400



atatgactca ggaaaaaaaa attcagagat gtgggaaagg aaattgagca aacatggcaa 65460



aggagcaact ggtgaatctg ggtgtggagt atatgagagt tctttgtata attcttacac 65520



cttttcagta agtttgaaat tacttcagga caaaagttaa ggggctgggt gcagtggctc 65580



atgcctgtat cccagcactt tggtaggcca aggcaggcag atcacttgat ctcaggagtt 65640



caagaccagc tgggcaacat ggtgaaaccc tgtctctaca aaaaatacaa aaattagcca 65700



ggtatagtgg catgcacctg tagtcccagc tactagggag gctgagaggg aagaatcgct 65760



tgagcctggg aggctgaggc tgcagcgatt tgtgatcaca ccactgcact ccagtgtggg 65820



taacagagca agaccatatc tcaaaaaata agtttaaaaa aagtttaaaa actttttaga 65880



aaggaggatt gcttgaagcc aggagcttga aaccagctgg gcaacatagc gagaccccat 65940



ctctacaaaa aaaatttttt taatcagctg ggcatggtgt cagatgcctg cagtcccagc 66000



tactcaggag gctgaggtgg gaggattgtt tgagcctagg acattgaggc tgctgcaagc 66060



tgcaatgtca cacactactg cactccagcg tgagagacag ggcaaaaccc tgtctctaaa 66120



aaataaccaa aaaacaaaaa aaactttttg cctatctcta agacctttga aaaaactgac 66180



caaaacaagt gaaaaggggc tctggagagc cgcaaacacc cctcactgcg tggtagtggt 66240



gttaatattg aataaactcc aattgcaatg atggtgataa tagaattggt attaatgtag 66300



gggtgtgtgt gcctttcccg ccagggcagt gtgccccaca gctgggtaaa agctgggtgg 66360



gggcccaatg cctgggcagg ctcagctcct gcttgggttg agagaactga ggagagatgg 66420



gggtcccata ggctccactg ctccagaagg actcctgggg ctcagatcac cctgctttga 66480



cctctcccta actctggggc cttgggtggg gcaggtcgtg catgtgggtg tcagggggag 66540



ctacttaccc acatagtgcc ctttgaggta gccctcacag tcacaggtct ctgggaagca 66600



aacagaggga gggaagccag tgagtcccac cagacacatc cggcccaggg cacccagccc 66660



ctggatggcc aggcaggaag agccccctgg gatggtgtct cgtggggagc tcaggggaaa 66720



tcccatgtcc tggacacccc aagaaagcaa ggtcctctgt tttgctcagt tctccatgct 66780



taggccccta acagcctttc caggccctga gggggattct aggccagcag gcctccccag 66840



tccctgagtg tgagcagtgt gaatagggag ggattcactc cagcctgccc tgccctccca 66900



ccccttgtct cctatccagc cccatcacag cgtagccgag tcctggaaag gctgggccgc 66960



acgtgtcagg agggcaggga ggtgccccta aggccttgaa ccctgtcccc accagctttg 67020



cctgcctcaa ggaacagccc agtccagctg gcagagcagg aagaggtgcg cagacagtgg 67080



gaggggcaca gctgcccaga tagggaaaga acacgagccc ctcaggcccc agacgttcca 67140



cggaaaaggg gccacgcctg tggacagcgg atagatactg ggcctacctt tgtcacaagg 67200



ctgatcatct gcggtttgca caaaagacag atggaacagc attagtggag ggaagcgggg 67260



accctgcggc tgagggcagc cacggcccga gtgcctgagg agcccgccat ctggcctctt 67320



tccctttcct ccaacgaacc tgtgatctga gctgtggtac gttattaaac cccaagacct 67380



gctctaatta gtcttcttgt atgtgtctca ttagcaccag agaaagccag ctcatcagtg 67440



gcacagcagc ctcaaggcca ctgcccttct aacctgacag caagtctgga aaagtggcca 67500



ttgtcagggg cccagggagc agcttactct aggatcctgc ggtgggaata ggacccactc 67560



tctcttttct ggggttggag tctggccctg gaaaacgcag atgcctgagg atggagcggg 67620



gtggagcaga gctgcaggcc atctgtgttc tggtcacctg gcacctgctc aggccgctca 67680



ctcggttaca agtctgccct ctagtaccag agagaccatg ctctggaaaa gcttcctctc 67740



tgcacggggc cctaccctgg ggctctgatc acaggccttc agaaaatgtg accccaactc 67800



tgctcactta accttgtgac cctacatatt cccagcttag aaaagatagc tgactctacc 67860



gacttcacag ggttccaaga agtaggtgga catgttttct aaagtgtaaa gtgctacacg 67920



gtgtagagtt gccagataaa atgcaggaca cccacttaaa cttgaatttc aaataaacaa 67980



caagtaactt cttagtataa gtatgcctca aatattgcac aggacatact tatactataa 68040



taaaaactac ataaaaacat acttatacta gaaaccaatc tgtcatctat ctgaaattca 68100



agcttcaact gggcatcctt tatttgtatt tgcccagtct ggcaatctgg cagccctacc 68160



agaggcacca ggtcacacat ggccttctcc attcccttcc aacgccagtg cttcttccat 68220



tttcaaggtc agagagccct tgggaatcta acgaaagctg tggatcctca cacgcacatg 68280



cacacgcgtg tgaacacaca cacatctgca cattttggga aagctgttaa catacccccc 68340



agcatcatct atggactcca aatatacaag ctcctctcca gggactagct gccccccacc 68400



tcctacttcc caccccctcc ttcctctgga gtccatgagc tcagacaaga cccctgatgc 68460



cccctccagc ccactgccta cttcttccca gcctgaatcc tccctcgccc taaccccggg 68520



ccctccctgg agtgccatcc ctgacaatct actcacaggg gggcttcctg aggctctggg 68580



ggctcggcag ggtgcccgcg gctctccggt agcttagtcg tctgcaggga cacaagggga 68640



tgggcgggcc cgtgagctgg gccagataac cacttgaaag gaaccttctg gaaaacttgg 68700



gaagccaagg cctggatccc acaggtgggc acacactgga cactctgagg gcctcctgct 68760



tagcactaag ttccaacgaa gggaacactt tcacagggct cactggctca ccaggaggaa 68820



gaaactgagt ctcttgctcc agaaatagct catccagctc aagatggcca cacaggatcc 68880



agcccggtgt acaatcctca gctggtcatt actctcctat ggccaatttc taaggagagg 68940



cagccccttc tctactcccc agcctcccca tctctgaggg agctgagaaa tagcagaatg 69000



actcccagga gaggccgagg acagaagtga ccctaattta acaccctccc ctcagcggaa 69060



ggctcagccc gggcagactg tccaatgtgg ccatgagtgg agaggtgggg ctctcagagg 69120



tcactagatt tccacattta aatgcagctg aagggccggg cgtggtggct cacacctgta 69180



atcccagtac tttaggaggc cgaggcggga ggatcacttg aggtcaggag ttcgagacca 69240



gcctggccaa cacggtgaaa ccccgtctct actaaaaaat acaaaaagta gctgggcatg 69300



gtggtgcacg tctgtaatcc cagctactcg ggaggctgag gcaggagaat ccaggagaat 69360



cacttgaacc cgggaggtgg aggttgcagt gagctgagat agcaccacta cactccagcc 69420



tgggcaagag tgaaaccatg tctcaaaaaa aaaaaaaaaa tgcagctgaa gagctgtccc 69480



ccacatcctc tggtaagatg ttgccaagac ctgtgaaccc taaaatggag atgggtctgg 69540



ggttcccgag gagacagagc ttcgttctca gacttcggca tctcagaatc gcctggaaca 69600



tttgttagaa tgtgagtttc tgggcaggac ccatggatct gcatttctaa caagtcccca 69660



ggtgacgctg aagcccccag ccagggggcc acaccttgag ggccactgaa atgggtgaac 69720



cccaaggtcc tgtccttacc acagtccaca caccaaaaga tgtgagggct acaacccaca 69780



gtggaagtca caactgccac cctctgaccc aagactgacc ttcctggaag tctaaagaaa 69840



taatttgaaa catgaggaac agtctatgtg caaagtaagt aagtactgca gccttataaa 69900



agtgaagaat tgggaacaac ctaatcgaag tgcagccaca ggaaagcagt gaaatcactt 69960



agctagttcc tctgagaagc cttccctgca ttcctggatg agggcgcagc ctcctaatat 70020



gaactcacac agcaccatgt cctcctccct tgcacccatc acgtttatat aaactgtgtg 70080



tttgaagagc gtctggcttt tccactgaac tataagctcc tccagggcag aaaccctgga 70140



ttcacagcag cccgcaagat gccagcacaa ggccagctca attcatccta aatacctgcc 70200



gcctaggaat gaatggcaca gctcctgatg agttagtata cagccactaa aatcacacta 70260



caaaaacgat gctataatat ggaaaatact cacgccaaaa atgtttaaaa aaaaaaaaag 70320



caagacccca aattctgtat gcaacactca cataaaaagc acagtaagga aacaaactat 70380



gcagtttaga taagggtgag acgtggggaa tttcctttca tagtcctcct cttcagtttt 70440



tttctgtttt tttgttttgt tttgttttgt tttttgagtc agggtctcac tcttactcag 70500



gctggagtgc agtggtgtga taacagctca ctgaagcctt gacctttttg ggctcaactg 70560



atcctcccac cccagcctcc cgagtagctg ggactacagg tgtgtgcaac catgcccagc 70620



taatttttta ttttttgtag agacaaggtc ttactatgtt gcctaggctg gtcttgaact 70680



cctgggccca agggaacctt ctgcctcggc ttcccaaagt gctgggatta caggcgtgag 70740



tcatcaccat gcccagcctc tcttctgtat ttttatattt tgtttatcag cattctctga 70800



gcatgcatta taaaatatac attaacttag gctggatcca gtggctcatg cctgtaatcc 70860



tagcactttg ggaggtcaag gcaggtggat cacttgaggc caggagtttg agaccagcct 70920



ggccaaaccc tgtctctact aaaaatacaa aaattagcca ggcatggtgg tgcacgcctg 70980



taatctcagc tactcaggag gctgaggcgg gagaattgct tgaacccggg aggtggaggt 71040



tgcagtgagc taagattcgc cactgcactc cagcctgggt gacagaggga gactctgtct 71100



caaaaaaaaa aaaaatacac acacacacac acacacacac acacacacac attaacttaa 71160



taacataaat ttccatagat tcctttaaat ctcaaataac catcatcact agttatggga 71220



aaagaccaaa cacaagtgca actggtactt accttggggg aacaatgctc agcaggcccc 71280



tctggctgtg agggcagaga cttgggggtc tgccatgtac ctgtgcctct gccactctgg 71340



aaccagccct tcacaacata ccccagaccc acctctcctg gaaccccttg gaggggatga 71400



ggccggctcg aaggttggtg tccccgactc gcttggcctg ccaccacgtg gggtcgtcct 71460



ggctcaccac ctccaggacc tgcctgcgct ggaagggcag gcccgcctcc tggcaaggga 71520



tggcccggtc ctcccgaggg ttgtagtgga agagggcgcg catgaacacc tgcacaagga 71580



gggctctggt gaggcggccc ttccccaagt gagcacagac aggtcattgt cacatcaaag 71640



gccacatgac aacgaccatc cacacttagg aggaccaagt ggcctttcaa atagaaagct 71700



acttggaaat acactgcacg tatgttctta actgttcttc aaccatttgg gatactatag 71760



tcaggaagtc catcaagaat cagaaaatta ataagcccca tgactgaatg tctctttcct 71820



acctaaatat ttccttattt acttgaccag ctgtcctcat aacagcctct tagcatacac 71880



acagcaacaa ctaatcctgg gaacaaaaag taaaggcaag cacaatttct aactcaagtg 71940



ttatttttga tacgccaact gcgctgacgg aaggcagcag ccatctgtta tataagtaat 72000



ctagatgttt gggtaagaac acaaatatca acaaaactac tgttactgac tcctcaccat 72060



cacttttcag tgggtaattg acacccacag ctcttacggc tcaatcctgc ctcgtctgcc 72120



atagactcgg ccaagcccta attcccccct ctgctctaga gtcaccctct ctggagaaga 72180



tggtgtgagg acacagcatt tttcacactt ccttgttctc ttcgataatt tagtggcatg 72240



gattaacttt atttatttct attttcagac cattagggcc caatcacttc agtggcaaac 72300



aggaaaaaaa aagcaatcag gggtcttcct cagacagata caaactctat tcctttgtat 72360



gccaaccaga aaagattcca ctggacaaca gtaagaactt tctggcatat gttgtgggga 72420



cagatgccct taaccagcca cagatgttac cagggtccta agcactcaga agaatgtaat 72480



cttaagtggc cagcccaaat caagcatctg gatcaagaag aaatattcaa gaaggacagg 72540



ctgggggaca ggctactcat tttgtccttt aggaaaacca agttctcttc ctcaaagagg 72600



tttcctcaag tcagaaccct caaagttgca tgtgcggacc acattcgctt gtcctaggaa 72660



gaatcacttt ccaccaggta agaggaaata ttatgccctg ggatttaacc aaagagcaca 72720



aataagaaac agctatataa agattatttc ttcacttgct gtaaaaaact gtcattgaag 72780



acgtagtcca ttacaaatcc acattcttca aagtatcgac tgacatctcc tctgtgctag 72840



atgctgtaat gtttcttctt tcatgcatta agtactgaga ggcaggtatg ggaatgtctt 72900



gaaaaactgg catgcttcct tccattctct gctcaacagt atgtaattca ttatgctctc 72960



ctttttgcct tggctgccag gaaactctac tatgaaatca aagtgatgcc ctcctctcta 73020



tctcatcaac caccatctca cagttcaggt cttaacgtct cacctgggct tttacaagag 73080



ccttctacca ggcctccctg cctccaacct ctacccactc caccctcctc cccgtggctg 73140



cctcacggag ctttctaaaa cacaaatata actgcaccac tcccatccta aaaaaaaaaa 73200



aaaaagagct tattagaacc tatgggatta tctcttgggc tgtgggatgc cctcccatat 73260



gccccagggc tggaccattc agtgcagcct gggctgactt ccagctgcca gcacctgcat 73320



ctctttgcct aaggacttac tttctctggc cactggaacc tactcatctc tagtccagca 73380



ggcagaagtt gctaggaatt aatcccccgg gtgcagcctg gcaggagttg gtatatagat 73440



cgcccagctc ccagggcccc tgggtgggat gatggaggcg tgtgttctac aggggaagaa 73500



gtagttcccc aagttcccag caggactaag ctccagctgc ccatagtggt aacctgcttg 73560



ataacacacc cttagtcaga ttggctgtct tccctttccc agtcctgtac tggtatttcc 73620



tggggccact tcccaaataa accatttgca ttcaatcctt gtctcagggt cagcttctaa 73680



gaggccccac actaagcaag gattatgcca aaacccttaa caaggcattc gaggccattc 73740



agaacatagg cttaacccac ctccccagca aaacccacca ccatcctccc ctcaaagccc 73800



caccacatag cccttaacgt gctcctctcc agagtgccag ggagcctctg tatgggcaga 73860



ccccaccaag gtcctactcg tctttacctt cttcaggcct cagttccaac acccccattc 73920



tgtgacaccc tctagggtga ctgtaactct ttgtacagaa tcttggcaaa gcacttatca 73980



catagcaatg aaagacttgc tgcccttctg caccaggaag ccttgcagct accaagagtc 74040



cctgtctcca gcatctggca gagtgcctgg cacagagtag gtgaccaaat aaggcaggct 74100



cagcaacaat taaacaaatg gcagttgctt aattggttca gaattcagca cacttggtac 74160



cttctcctcc tcttcatggc cctgagtttc tatttcaatt aaaataacct tgtcttttat 74220



tagtaagcca cgtcaaatcc tgtttagaaa gaggcaggat acaaacaaat gcatcacttt 74280



gtgacggaat taaagtcctc cactgggcac agattactag gatcagatct atgatctgtt 74340



cgcaaatgac tgttacaaga gactggactg gatccagccc ccagccagcg agctgcatct 74400



ctcaagctga gagagggcac cgcggaccca cctccccata ccttgctctc ctttaagcga 74460



tcttcctcct gggtggctgg gatgattttt agggtgatgg atccctggga ctgggcctga 74520



aacgaaagag aacagaagct tctcgcctac caggtctaac cctccaagag ttcaactcct 74580



acttctcagg cctaaaaact gatgttcaga aagtcagact tgcagcctcc cctgaggccc 74640



actcttctag gatggtgccc tggttgaatg aactaaaaca aaactcagta accaagtaac 74700



tgtacatttt tgtatttttt agtattttta ttatttttaa gccagttcaa atttagcagt 74760



ggcgggttgg taactgtatt ttcaaaagtc aaagggacgg aagactttcc atgagaaccc 74820



aaggacacta cgtgttgaat tccaattctc catccctcct gaccgctacg gccccagagg 74880



gctcccttcc ttgcttttct cctgggtcat ctgaacaacc catttcggtt tcctttgcct 74940



ctttcctgcc tgatttgggg ctggtctctg attaatactt ccctctttgc ttccatctcc 75000



ccagtctcag gccatgccca gctttctagg agctcccttc accctcatct acagagaccc 75060



tgtagcccaa tgccaggggc ccaacaaagg aagaatgcag tcggaccagg acagcagggc 75120



ccaaaagatc acctcctggc ctctccacta cccagaaagc ccagaccctt gctctggagc 75180



acaagaaggt tggcacccaa agccacaaaa aagcaagctt gggcaaaagg actgaagggc 75240



ctgcctgcaa tccgcatcct ctacagagag ggctttattt tgttgttgtt tttttgtttt 75300



ttgagatgga gttttgctct cattgcccag gctggagtgc agtggcacga tctcgactcc 75360



ctgcaacctc cacctcctgg gttcaagcaa ttctcctgcc tcagcctccc aagcagctgg 75420



gattacaggg gcccacaacc acactcagct aattttttgt atttttagta gagacggggt 75480



ttcaccatgt tgcccaggct ggtctcgacc tgacctcagg tgacccacct gcctcggcct 75540



tccaaagtgc tgggattaca ggtgtgaact actgagccca gcccagagag ggctttaaac 75600



agtgggcctc ctcttttcag atctcatcct gtttctgccc ccaaaaccat cagaagttag 75660



cagagtgtca ggtcagggga ggaatcctga ggataaaggg gaccaagcta tgattggggc 75720



ttttcacaat ttcagttttg acttcaactc cccagaatgg accatggagg ttttcagcca 75780



agcattttat accttaaaat ccccttacac ttctgaaggg ctttaccctt ttccagatgt 75840



tagcatgcca atgataacca cacattggtt gagaaagaaa ctctatccca acgttaaagg 75900



aaaggaaatg gaaactcaga tgatctgatg gcttgtccaa ggttgcacag ctggaaggag 75960



gcagagccag gattcacacc caggacccag gacccaggag gggccttgtg aaagggaacc 76020



aggggaagga aggaaggctg tgctgaggag aaggtctaag agaggcagat ggaagggaag 76080



ttcccctcct cctgctgcca ccccataccc cgggcacact gttaggggca caccataagg 76140



ccactttgcc tgccacctcc tcaggacaac agcaaggcta agccagaatc tgtcctggct 76200



ccaggaagtg ccttgctctg ggtgtctgaa gacccagcac atccctagca ggcttgtagc 76260



acggaccaga atctggctga tctcgtcggg ccgcttgtgc aggactgcga tcccgttcac 76320



ttctcggagc tcatctccaa cgtggaccag gcctaggaga cacagggact gaccatcagc 76380



acaggaggag gacctgagca cccctcgctc agagctccaa gcaccacagg ggccggcctg 76440



agaagcccac tgcagggcca actcgaggtt taaagttgat gggtgggact ggggcgaact 76500



aagccctgct aagtgctggg cacctcactc ggcatgcagg gctcaaatca cccagtaaaa 76560



tctccaattt acaagttggc acctgagacc caggaagatt aagcagcttg cctaaggcca 76620



cattgctgag aaataatgaa gccagtattc aaacacagtt attatgatgt agaaagcctg 76680



tgttcttttt gctataatct ctgcttcttt aaaattatca ttaactctta gaatggcatt 76740



cttaagtctt aacaaggaaa gacaaaggca ccaatgaaga catcattaag agtgtaaaca 76800



cactatgagc ctctgcctga atgactaatg tctctgcata ttagggccct atatgctact 76860



caaagtgggc actggcccgg ctgcatcagc atcacctgga ggcaggttaa aagtgcagaa 76920



tcttcggcct agctcagacc tgctgaatca gtctgcattt taacaagatg ctcagggaat 76980



tcgtggactc gttaatgttt gcaaagtgct ggtctaggat tctctgcaac gatgaccccc 77040



cagactttgg gggtaacatc gccctatacc aggaggtttg tctcccagct tagtagctct 77100



tccacacacc ggtgattctc aacctttcta cccaaacgaa tctggggcac aaacactctc 77160



tttgtaatag tagcttgaca agacctggga tggtggggaa gggtgtcaac cctgtcccac 77220



agttagtaat cccgcaagcc catgctatat tcttaactgt cacagtcctt ggactaaacc 77280



aacgcatgag ctttttctca atcaccccaa agtactccat gactatttat atatatatat 77340



attttttttt tttttctttt ttttttgaga cggtctcact gcgtcgccca ctctagagtg 77400



tagtggtgta atcacggctc actgcaacct caaactcctg ggctcaaaca atcttcctgc 77460



ctgggcctcc cgaacagcta ggactacagg tgtgggccac ccgtgcatgg cctatatttt 77520



ctttttcttt ttttcttttt tttgagacgg aatttcactc ttgttgccca ggcgggagcg 77580



caatggcgcg atctcggctc actgcaacct ccacctccca gattcaagcg attctcttgc 77640



ctcagccttc ccaagtagct gtgattatag gcatgtgcca ccaagcctgg ctaattttgt 77700



atttttagta gagatggggt ttctctgtgt gggtcaggct ggtctcgaac tcccgacctc 77760



aggtgatccg cccacctcgg cctcccaaaa tgctgggatt acaggcgtga gccactgtgc 77820



ctggcttttt tttttttttc tttttttttt ttttttgaga cagagtctca ctctgttgcc 77880



cagactggag tgcagcagca tgatcttggc tcactgcaac ctccgcctcc caggtttgtg 77940



tgtttagtag aaatggggtt tcgccatgtt ggctaggctg gtctggaact cctggcttca 78000



agtgatccgc ctgcctcggc ctcttaaagt gctgggatta caggtgtgca ccaccatgcc 78060



cagctggcct atattttcta ttaaaatttc tactgacttg ggaaggagat gagaattcca 78120



gccacaaccc cagaaagcaa agcaaatccc aaacaggtga cctgatagga gggaggtaag 78180



gggacctatt agcaaaggtg gagggctctg gaacaatggc catgatcggg gctgggccag 78240



ctttgcactg ccgccactca ccgctcctgt ctgctgcgcc tcctcgcatg atcctggcca 78300



ccacaacagc ccctgagtgc tcgtcccgcc ggatggtggc accctgaacc cgagacagaa 78360



gagacaggtt cttaagcagc agctccaaac ctcagacccc tactctctgg acccaacaca 78420



gcctccccag tccctccctc tgacagtcca gagagatcag tggggacctt cccaatgctg 78480



aagacaaaac aaaaccaaca tcccccatta atatagccct gcactgtaca gtttacaagg 78540



cacaataatg ctgcaacatt ttagatgagg gactggggct cagagaagtt aaatatcctc 78600



aaggtcaccc agctggtaaa ggggaaagct ttttgtgatg ccaaatccag taagttctcc 78660



atcacatctc tctcatatca cagttcctac cacttgcaaa gacatttaat aatgaggatg 78720



acacgtgcca gctaattctc accctgcctc tacccaatca cagggttacc gggccttctg 78780



ctgctgctga gggaaaccaa ttatgcaccc cagccagggc ttcgggacca ggacttggcc 78840



catgaagcac agcagagatg acacttagga tgagaaaggc actaacgagc cctcgatttc 78900



ctgcaccaca caggccggac tgcagcagga cggcagaaag cttaagagct aagctctagg 78960



gctggacagc cttgggtgtg aacacagttc tgccgtttac aaaaagcatg tggacttaac 79020



aaggaaatct cttatcctct ccaagcctgt ttcctgtgag atgtgggaca gcatttaact 79080



cacagtgttg ttgcaaggat tccactcaag gcacttagta cacagtaagc actcaacata 79140



tgttaaccac ttattagtgg ctgtaactgc aaacacattt gcacacttat tgttaacatc 79200



atctgtgcca tctatttgaa gtacgtaaga taattattgc tagaaagaga ggccatcagc 79260



taagaacctc aggacttcta gccccccaga actgagaact ttccagcatc gctatccatc 79320



atttattcag ctctgaaccg ccagcaccca atacagagcc tggataggag ggctcacaat 79380



gtgtttgcta aatcaatgga tggccactcc attttacaag tgaggaaaca gaggcagagg 79440



agagatcctc gtctgtttgc agaagaggct cgtcggaggt catttgggga aagttggaaa 79500



tagagaatgc cagctgtggg atcctctgga gccaatctca attctctggg cttccaccac 79560



ttctgagcat ctcataaaca acgctgtccc tttgctcggt aaatcaatgc tgaaccagga 79620



ccaaagtgat agcagtctgt ctgctgggga gaggaatgcc ctgtgcttcc tcaacattca 79680



gagcaggcat tgtcacacgt tttctataag gggccacatg taaatatttg aggccagcca 79740



cacagtctct gtcacaacga ctcaactctg ccatcgcact ataaaggcag ccacagccaa 79800



tctgtaagtg aatgggcctg gttgtgctcc aaaaaagctt tattttaaaa aataagctgt 79860



gggctggttt tggcccttgg gctgtagttt gtccatttct ggcttaaagc atgatcaggg 79920



tcaccctgta caattgtgca ggttattaac tacacaaagg gtgttggcca cagttgagag 79980



gggctgtatc cacctagaga aaggggtgcc ctgcacacag aggcaccaca gggatgagca 80040



gcagcgcagg caaagctgcc gtcactcact ctgaagactt cggggaggat cttgtccagt 80100



gttctgggtg ggggtgagag gcaggggaag agtgggttag agaggggcag gcagcagcac 80160



ctaccagggg ttccttgttc ttcaccaagc ggacgatctt caccgattcc tcatcaaaat 80220



cctcatcgat attgtcaggc agaggcggga gaacggggtc aaaattcttc tgggcaaccg 80280



tgtcatgtac catgagcaca gcctgccggg aaagccagag aaaaggaagg ctggcccgcc 80340



gctcacaggg tcagcaggcc gcagctggcc ggtggtatgg agggtggcag acgccatgcc 80400



agagagacaa ctgcccagac actagtgctg aggatcgctc cctcagtctc cactcctcag 80460



cctcattagg agagctccct ccgcccccat cccaggagac ccagaggcat ggctgggcag 80520



gggctctgtg tgactaccct caggtgcggg gtggacagca gctggagcag ctccctctca 80580



tcactgtgca cggaggcggc ctgcaactcc tccatcacct gcagagaatg agacaggcgc 80640



cactgatggc tagaggtgcc cctgccccat atctgctggg tccttcctct ttggaagggc 80700



ccacccagct gcagccccca ggggcacacc agaccctcaa ccacccgacg acgatgatcc 80760



tgggaacatc acaccagggg tcaggagcag ctctatgggg ccatcctcca aggagccacc 80820



gttttaagcc ctacgtgctt tctgctttat gtggatcttc tcactgaacc ctcgcaacca 80880



acttgatgca gagggtcttg ttactttgcc attttacaga tgagaatcct gagactcaaa 80940



gagattaaac attttgcccg aagtcacaga gctcatatac agcacagcta ggatttgaac 81000



ctgggcttat ctggctctca gatgctattt tatgaatgag gaaatgggag ctcagagagg 81060



ttgagtggcc tacttaacat cacagagctg gtgggacagg cagcgctgag cctgggagcc 81120



aggcaatcta atgtgcccct aatcacattc cacagtggag aagggcccag ggctctgcac 81180



ccacaagctg cactcatccc tccccaggcc atctcctggg gttaggtgag tttattcagg 81240



aactgatctt agtaatcaac cagaatgggt tttccccaac cacgcaacat agacgactag 81300



gtccacaaga aattaagaag cgttccttta aaaaatgaga agcctgagcc agtatgcggg 81360



gacacactgt aggtcccttg acttcaggaa agcacagaca taatgtctta ttgacctatt 81420



caaatcacca gtcctcaggg cagtttggga actgctgagc caatccaatg ctctcattta 81480



cagcagagga agcagacttg ctaaagaaca cacagtaagt gggcagctcc atgtcacagt 81540



gtctcccagc ccagtccaag gctcacgggt tcctccctac ctttcgggga acccagagag 81600



aggaagagaa ggaggaggac aagggaagaa aacacctctt cacctttggg ctcctgattc 81660



ccggtgtccc cacactaagc aagcgaggca agatgaagga gccctacagg gtggggagtg 81720



gggcagacac tgtaaggaga aacctggggc ttacgtcctc agcgagggcc acagcgctgt 81780



gcagaactgg ggttggactt tgcctttcat aatagcgaag cttctcatga atctgcaaag 81840



acagagtatt tcagatgcac cctggacacc acacatccca cccacggctg tggggacatt 81900



tggggcagca gactgggcca ctgacagggc accataagag aaagtcctgt gtagtgggca 81960



agtgaaggcc ttcctggggc agggagatga ctaggatgac ctcagacggc cacagacagc 82020



tagaaagacc tctagacacc cttccacgca ggatgacgtg ggacttcacc ttcattaagt 82080



aactgaggct tttttcactg aaaacatccc tcaggaagcc catctcctcc ttgtggttgg 82140



agtcaggtct gagctgggag gtcagcaggg ccagggtttc atgcaaacct ggggagaggt 82200



gagaaaaaca aaggatagca aacgcagtgg gtgctccctg cccccgagga gcccgagtgg 82260



ggcctcaaac agcacttcag tcctgccgtg aggacattct ctccccaggc tctcactgcc 82320



agggcctgga ggctgccagg caggctcttg tcttcaggac tgtggcaggt ccagccgggg 82380



ggaggtactt accagagtcc tccgatagca ctggcatgct ggcgttgtca cctcccgacc 82440



tctccctgca gattctggga gaagggggtg gaggtgggta ttgaagctcc atcaagcata 82500



tttattgaac aaactgacta cacatctact gtgttctctg agaccaggct gtggacagag 82560



aggatgggaa caaataactc tgcttacttt tttcagagag gaaggaaata aagctaagat 82620



gtgctgagtg tcctcgatgt gccaagcatt gtgtggggtg atttctatga taaacttttt 82680



gtctgcacaa agtcctgaga aatgactgcg aatgttccca ttttattgat gaagaaacag 82740



cggcgtggaa gctttcagta agctgtgggt caaaatccat attcaagcag gctcttccag 82800



gctggccttg gaggtgccaa gtgaccctgc ctgacagtgt cagctgtcct ccgcagcgcg 82860



ccccctccac tgcaaccttc taagagccct ggctcaagtc tcctgctggg acacaccttc 82920



cacaactacc tggctgggcc tacaagcccc ctgtccccga ccccccaaga cccaacccaa 82980



agggagcctc cagactggag tgcagagagg agggggggaa atgggagtcg ggcttccact 83040



atgcaggagg ggggacccct atctcatgag gccctccaaa ggtgctctgc agcacgtgga 83100



cctcaaaaag tcctccttag gaagaggaga aggagagtca tgactgattc attccgcaaa 83160



catggagcca gcccgcagcg ccgagccccg gtgccactaa gaggcgtaag agcggccccg 83220



ggccctccag cctccgcccc gccccgcccc gccacgccac gccggactca ccctcgggct 83280



gctccccgca ggaggccgag caccgactcc cgctcgctct ccgaaggaac ctgtgggaga 83340



acaaggagcg cactgggcgc aggagcagcg accccggggg acctcggagg gcggtcccgg 83400



aggacgcgga gcagcaggga gcggggggcg cgcggcgggg cgggcgcggg aagagggagg 83460



cgggggccga ggggcggggt tgagactccc gcggtgggct cggtgggccg cgaggctgtc 83520



cgggagcacg ggaggagggt ctcggcccgg cctcccgccc ctcccgccgc ggcgcccagc 83580



tccctcgtcc gttcccctcg cggcctccta cctcgtcgcg ccgggatgtg tgctccgcga 83640



acgggagccg cgcgagtgcc cagagcctgg gccgccgctg gctccgcctt cccggacccc 83700



tccctgcggc tgccgcgccg ggcgggggtg gcggagcctg aggaggcgcg gcgcggggag 83760



gaggcgcggc gcggggagga ggcgggggag gagcggaggc cgccctccgc gtctggcacc 83820



gccgcaccct ccgggccggg ctccgctagc cggcgtcgta cccgctcccg ctctcccgct 83880



ccctgagtcc cctgcctgtg tccccccgca ccctggcaca cagccagact tcccttccgc 83940



ccgcgcaacc caccctccgc gagtggaggg gtggacacct gctcaacaga gaattcgatt 84000



ttgcaaacat ttattgagcg ccctccaggt gccaggcgct gtgccagggg ccggggcttc 84060



aaagacgacc aaggcacaga tcctgggttt gaagatctcc agaggtgggg cggggggccg 84120



gtcggatgcg agggcaactc gctgtaacaa tgcaacgcgc tgggaaagat ttatcggtgc 84180



acgctgccct ggggacgcgg agcaggggag gagaagtcag gctggagagg agggggactc 84240



cattctgccc ggctgcaggg gagtgaggct acatagcaga ggcgagcagc atccaggggc 84300



tttactggaa aaagagctct gaaatggcca tgacgataac tgacttatat tgtgctgtct 84360



ccatgcccag gtactcctca gatcacttcc cttcacagta gttcctgata tcaagaccat 84420



tcttattttg gttctgcaat tgaggaaact gaggttcctg gtgaaagaat gtgtataggg 84480



gagagcatag gaactgctgg gtgagtgagc aggtggttgt gggtattaaa aggtgaggag 84540



tgggtgagtg agtgggcccc cttccctcaa tcccagcagc aaagaacggc acagcacatg 84600



tcaggagagg tggacccaga ggttaagtct ggaagtaaat ctagccctgc acagtaacca 84660



gggaaaatgg gttggcaggc cccacaggct gtagtgcatg gggaggctgt gagaggcagc 84720



aaatgtcatg atgatgtttc ccctcattcc tcaaaaatta tcctcattcc tcaagaaata 84780



tctacactat tgctcctcaa aatgtaacgt gcctgagact cactaggggg ttgtgtaatg 84840



ctggagtggt gccagattct gaatttctga caagctccca ggtgatgtga cgccactggt 84900



ctgcagacca cactttttga gtggagagag actgcatgag acacattctt agctgcaatg 84960



tttactgttg gaaaaataat gagaaccatc tgatccatct gatatgggtc aaatgatttt 85020



ggacaagaac accaggaagt ggtgttggaa caagtagata tttatgtgcc tgaagggacc 85080



caatccctac ctcacaccat attcaaaacg caatttaaga gagatcattg gcctaaacat 85140



aaagcaaatc gataaagcta ctagaataaa acaggagggt atcttttaaa tcttggggta 85200



tgcaaagatt tcctagaaag gatacaaaaa agccaggcat ggtggcatga gcctgtatcc 85260



cacatactca ggaggctgag gcaggcaaat tgcttgagcc caagagttca aggctgcagt 85320



gaactatgat cagtccactg cgcttcagct tgggtgacaa agagacaccg tttctaaaaa 85380



aagaaaaaat ttttaaaaaa agcatggacc ctgaaaacaa ttgataaatg gacctcatca 85440



aaatttaaaa ctcctgctca tcaaaaaaca ctattggcca ggtgcagtgg ctcatgcctg 85500



taatcccagc actttgggaa gccaaggtgg gtggatcatc tgaggtcagg atattgagac 85560



catcctggct aacacagtga aaccccatct ctactaaaaa tacaaaaaat tagccaggca 85620



tggtggcaca cacctgtgtc cgttccagct actcaggagg ctgaggcagg agaattgctt 85680



gaacccggga ggcagaggtt gcagtgagcc aagatcaggc cactgcactc cagcctgggt 85740



gacagagtga gactccatct caaaaaaaaa aaaaaaaaag accgggcgca gtggctcacg 85800



tctgtaatcc tagcactttg ggaggtcaag gcgggcagat cacgaggtca ggagatggag 85860



accattctgg ctaacatggt taaaccccgt ctctactaaa aataccaaaa attagccggg 85920



tgtggtggcg gaggttgcag ggagtggaga tcgcgccact gcactccagc ctgggccaca 85980



gggtgaggct ccgtctcaaa acaaaacaaa acaaaacaaa acaaaacaaa acaaaacaaa 86040



acactattaa gaaaatagga ccagggacca ggtgcagtgg cccacacctg taatcccttc 86100



aagcacttta agagttcaag gcgggtgaat ggcttgagcc caggagttcg agaccagcct 86160



gggcaacacg gcaaaaccca gtcggtatct actaaaatta caaaaactag ccaggcatgt 86220



tggcttgtgc cagtagtccc agctgctcag gagactgagg caggaggatc acttgagcct 86280



gggaagcaga ggttacagtg agccatgatt gtgacactgc actccaggct gggtgacaga 86340



gtaagaccct gtctcaaaaa aaaaaaaaga aaagaaaaga aaaaagaaag aaaaggaaag 86400



gaaaagaaaa gaggcaagcc acagactggg agactaggaa gaaatatatc tgacaaagag 86460



attgtattca gaataaagaa ctcctgtaac tcaataaaaa gacaaaccac ccaatcaaaa 86520



aacaggcaaa agatatgaac atgcacttca caaaagaaga tatacaaata accaataagc 86580



atatgagaaa gcactcatcc aacatcattt gtcatcaggg aaatgcaaat taaaacctgt 86640



catagtcagt tcctgctgct ataacaaaat accacagtaa tttataagaa gtaatagtaa 86700



tttattgctt acagttctag aggccggaaa gtccaagatc aaggggccag ctggttcagt 86760



gtctggtgag ggcctgttcc tcactgatgg cactggatag gtatcctcac atggtggaag 86820



agaaagacag gcataggcca ggcgcggtgg ctcacgcctg taatcccagc accttgggag 86880



gctgaggcag gtggatcaca aggtcaagag atcaagacca tcctggccag catggcaaaa 86940



ccccgtctct actaaaaata caaaaaaata gccaggcgtg gtggcaggca cctgtagtcc 87000



cagctacttg ggaggctgag gcaggagaat ggcgtgaacc cggaaggcag agcttgcagt 87060



gagctgagat cgcgccactg cactccagcc tgggcgacag agcgagactc catctcaaaa 87120



aaaaaaaaag aaagaaagaa agacgggcat aaagggatga acgctgtgtc ctcatgtggc 87180



agtaggggcc aaagggacta gggtgctccc ttcaagttct cttataaggg cattaatccc 87240



attcaagtgt ccatcaagaa gtgaatggat aaatattcat tcacttgtgg tatatccata 87300



caatggcata tttactcacc aataaaaaga aacaaattac aagaaagaaa tgatgaaaaa 87360



atttaagatg gcagagtata caattgatat taaaaattta tgactttccg gccaggcacg 87420



gtggctcacg cctgtaatcc cagcactttg ggaggccgag gcgggcagat cacaaggtca 87480



ggagatcgag accatcctgg ccaacatagt gaaactccgt ctctactaaa aatacaaaaa 87540



ttagctgggc ttggtggcac gtgcctgtaa tcccagctac tcaggaggct gaggcaggag 87600



aatagcttga accagggagt cagaggttgc agtgagccga gatcgcacca ctgcactcca 87660



gcctggtgac agagcgagac tctgtcttaa aaacaaacaa acaaacaaaa aaaacattat 87720



gactttcctg tggacaaaaa taattattaa gtataatgaa agaaaaaatc caaactaaga 87780



tatcaagaaa gattaaatac caatttataa acttaatagg aaaaatgaaa gacctattga 87840



tatttgggag aaaaaaactt taaaattcta gtgaaggaca taaaagataa aatgtacctc 87900



aaatggctag ggaaagaaca gttcaatagt gcaattatat taattcattc tgaaataatc 87960



tttataccca atgcaattcc aattaaaata taagaagtat ttttcacaga gaatttatta 88020



aatgctacca caattcatca ggaaaaataa acattggtga ataataggaa agttctggga 88080



aaaaaagagt tatgggacca agggaggtgg gatttaaaaa tatgaaaaca atttttaaag 88140



tttagtactg aggctatagt cccaggactc tgggaggccg aagcaggtag atcacttgag 88200



cccaggagtt caagaacagc ctgggcaaca tggcaaaacc ccatctctac aaaaaatgca 88260



aaaattatct gggtgtagtg gtgctcacct gtagtcccag atgctcagga ggctgaagca 88320



gaattgcctg aacccaggag ttcgaggctg cagtgagcca tgaccacacc actgcactca 88380



agtctgggtg acacagcaag accctgtctc aaaaaaaatg aattaataaa gtttagtact 88440



aaagaggcaa tcaacagcta gacaaataga acagaattga aagaacagaa atagtcctca 88500



tgtatactgt cttttaatat ttgagaaagg tgacatttaa gtggaaggag aggaattttt 88560



tttttttttt aatgtgggga caggccaggt gcagtggctc acacctgtaa tcgcagcagt 88620



ttgggaggct gaggcgggag gatctcttga gcccaggaat tcaagaccag cttgggcaac 88680



atagcaagac ctgtctctac taaaaataaa aaaattaaaa aaaattgatg catgtgcaag 88740



tagacccagc tactcaggag gctgaggtgg gaggattgct tgagctcagc agatagaggt 88800



tgcagtgagc cgtgatcatg ccactgcact ccagctcggg catcagagca agaccctgtc 88860



tcaaaataaa ataaggtatg gcgacaatta caatagctac tctttatggg aaaaaaaaag 88920



agagaggaaa aaaggctggg cgcagtggtt catgcctgta atcccagcac ttcggtaggt 88980



ggaggcgggc agatcacctg ccctcctctg caagattata aaaataaatt tactgagaaa 89040



atattttgat gtgagaagtg aggtagggat acagctttct ttcgcttttg ttttgagacg 89100



gggtcttgct ctgcggccag gcgggagtgc agtggcgaga tctcgtctca ctgcaagctc 89160



cgcctcccgg gttcaagtga ttctcctgcc tcagcctcct gagtagctag gattacaggc 89220



acccgccacc acacccagct aatgttgttg ttgttgttgt tgttgttgtt gttgttgttt 89280



gagacggagt ctcgctctgt cacccaggct ggagtgcagt ggtgcgatct cggctcactg 89340



caagctccgc ctcccgggtt cacgccattc tcctgcctca gcctcccgag tagctgggac 89400



tacaggtgcc tgccaccacg ccaggctaat tttttgtatt tttagtagag acgggatttc 89460



accgtgttag ccaggatggt ctcgatctct tgacctcgtg atccgcccgc tttggcctcc 89520



caaagtgctg ggattacaag catgagccac cgcgcccggc tgcagtgagg gaaacatttc 89580



taagtaaatt ccaaatccaa atctataaag gaaaaggtgg atatgtgtga tttaaaaaag 89640



ggtaaacatt tttataggta aaaatattat ttgcaacata tgatatcata tgcaatatga 89700



taaagttaaa ttcctcaatt taaaagagtt tacataaatg agaaaagatg aaaaaatttt 89760



aaacggtcaa agaaaatagt ctaatacaaa aaatacatag ccaataaaca cagaaaactg 89820



atgctagatc tcctgtttaa aaaaaaaaaa aaaggaaaaa aaatccaaaa gatgcacaac 89880



ctcactcata atcgaagaat tcttagccaa aataggaggc aatgtccctt gttaagacaa 89940



aaatgtttaa gtctgttgac atccagtgct atcaaggatg tggggaaaag acacatttac 90000



acatttggaa ggaatattat ttggtgcaaa ctttctggga cacgatctgg taatatttgt 90060



taaaatatta tatgtacatg tcctttagtc cagaggatat ttgggcaagc agaatggaag 90120



aaaagagaag cagagagaga tgtttaggtg gatgagagct tggagcagga gtgctgggag 90180



aggctgcatc ataggacagg gcaggtgcag ccagggcgga gttggcccag atggccggaa 90240



gctcagggca ggagtcgcct cacccagcca gggctcggtc aaggtgctcg tttagagcag 90300



ctgcacaggg aacaggaaga tgagctcaat gccagaggaa tgaatgactt tgggtccatc 90360



tggacaggga gaagagactt taccaagcat gctctggaaa aaaagagaat gccaacgatc 90420



cttgaagagg tgacagagag aatctgcttc aggctacagg tgtgcattgt cattgcattt 90480



ggcattcagc ccagacacca tagggaacca gaaataattc caagaggagc aatgggctag 90540



tgcccaggca tgcagcaaga gggcaagtca gaagcgggtg gagaaagggc aggctcagct 90600



ccatttactt ctcaatgaga agggaaatta ctgtactggg gttttggggt ttttttgttt 90660



tgttttgttt tttgagattt ctgataactt ttcctattgt ttgtggcttt tgttacctat 90720



ttctcttatt tttatttttg ttttattttt ttgagacaga gtattgctct gtcacccagg 90780



ctggaatgca atggcacgat ctcagctcat tacaacctcc gcctcccggg ttcaagcgat 90840



cctccagcct cagcctccca agttgctggg actacaggca tgcgccacca ttcccagcca 90900



gtcctagaat tcttatgttg tgcttttttc aaatctgctg tcactttttg ttctttccag 90960



ttccctgcca aaaatgtcaa gcttgacttt tacctccttg agcacagtaa gaatagttgt 91020



gttaaggctg atcctgctat ttacagtata tggagtcccc acgggtctgt tttgttgttt 91080



ctgcatattc ttgcttattg agtcttctca tagatttggt tatctttgat tatatattag 91140



atggtatttg aaaaaactac ttgtaaaaat gatcagctta ggctgatgct attttcctcc 91200



agaaaggatt tttcactaat atctttaagg tacccgaggg tagggatggg gaaggtgctg 91260



ccagacaaga gccactttta attcaagttc aaagcttgaa gtttcctggg acacctaaat 91320



gacagaaagc tgggtggaag tccatggtgg cctggtttgt acagcctttt ggggtcccag 91380



cctaatgtga ccaaaaatat gccagattcc attccctgcc cccagagggc cctagactcc 91440



tagttcatcc tcttcgctgc tgctttggaa tcagtaaatg cccacaggga aaacaagcac 91500



atacactgag cttatctttc tggcttcctg tctacttgca tgcagactta tgcctgggaa 91560



cccccatgct ctttttagct tttcactgct tttttttttt ttttaagaca gtctcgctct 91620



gtcacccagg ctggagtgca gtgacatgct cacggctgac tgcagcctcg acccctcagg 91680



ctcaagtgat cctcccacct cagcctcccc agtatacttt cttttttctt aataaacttt 91740



atattttgga ataattttag atttacagaa aagttgcaaa gatagtacag agagttcctg 91800



aacacccttt cccctgtttt ctctaatgtt agcatcttac ataatcatga tacatttgtc 91860



aaaactaaga catgaacatt ggaatgttat tattaaggaa attccagact ttattaatct 91920



ttcactagtt tttccactaa tatcctttct ctgttctggg atccagtcca agataacaca 91980



ttgcagttag ccttcaaagt ttctgagaag atttgaaatt tacctatcag taaacgtggg 92040



catttactga ttgagctcct gaggcattac cagtctccca ttactgccct cctccatcat 92100



tttccctgtc attccccgaa gtaattggtt aacataaaaa atttgaaagg ggccgggtgc 92160



ggtggctcac acctgtaatc ccagcacttt gggagaccga agcaggcaga tcatttgagg 92220



tcaggagttt gagaccagct tggccaacat ggtgaaaccc tgtctctact aaaaatacca 92280



gaaaatgagc tgggcatggt ggcacgtgcc tgtaattcca gctactcagg aggctgaggc 92340



acgagaatcg cttggaccca ggaggtggag gttgcagtga gccgagatcg cgcctgctgt 92400



ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa ttgaaaggga gttttcagat ttgtttgatg 92460



gagaaagttg aaaaatcgag tttgcaacca gctagggtag ggaagctgcg aggagactag 92520



aggatgaatg tatgacggaa aacaaaaagc atggtggtgg tctacactgt gctacagcaa 92580



ctagcaaact gcaagatctc cgtggctaaa cacagaaaag tctatctctt gctcattcca 92640



agtccgccgc acgcttggtg gctgtccagg gcagctgtct tccaagtggt agctcaggaa 92700



tccaaatctt cctgtcttgt ggctcatttg tctttgccgg ggacacgtct tccccactcc 92760



tgatgtttcc ttccatgagc agagaacccc actggcacaa aactcttagt ctctctccac 92820



gcctctctct acgcctctcc acacctctct ctacgcctct ccatgcctct ccacgcctct 92880



ctccacgcct ctccacgcct ctctccacgc ctctccacgc ctctctctac gcctctccac 92940



gcctctccac gcctctctcc acgcctctcc acgcctctcc acgcctctcc ccgcctctct 93000



ccacgcctct ccacgcctct ctctacgcct ctccacccct ctctccacgc ctctccacgc 93060



ctctctccac gcctctccac gcctctctcc acgcctctcc acgcctctct ccacgcctct 93120



ccacgcctct ccacgcctct ctccacgcct ctccacgcct ctctccacgc ctctccccgc 93180



ctctctccac gcctctccac gcctctctcc acgcctctcc acgcctctct ccacgcctct 93240



ctccacgcct ctccacgcct ctctccacgc ctctccacgc ctctctccac gcctctccac 93300



gcctctctcc acgcctctcc acgcctctct ccacgcctct ccacgcctct ctctacacct 93360



ctccacgcct ttctccatgc ctctgctgat ttgattgatg aatgttgaag gaggaacaag 93420



gcgtgtgtaa cccggctctc ttcttccttt tctctggtga gctggcccac ctgcaaaaag 93480



tgtgtgttct aaactgatac accacacctc accctgagta ttacgaggat ggcccagctc 93540



cactgaggaa agaaggacgc agttttacct gattctgggg ttcagcatta ggttctgccc 93600



actgtcctgt ttccaaaacc gtgttactat gcctgcatca agcttatcca cccgcggccc 93660



acgggctgca tgcagccagg atggctttaa atgaagcccc aaacaaactc gtaagctttc 93720



ttaaaacatt atgagattat ttttttaact catcagctat cactggtgtt actgtatttt 93780



atgtgtggtc caagacaatt cttcttcttg gcccagggaa gccaaaagat ggaacaccct 93840



gacctacata aacaataaac ataacttaca caaaagtgca cttatttgtt ccacagttat 93900



tcatcatcta agacagcagt tctcaaccca gggtattttt gcctctcagt gggatgtttg 93960



acaatgcctg gaggcttttt tttttttttt ttttttgaga cagagtcttg ctctgtcacc 94020



caggctggag tgcagtggcg tgatctcagc tgactgcaag ctccacctcc cgggttcacg 94080



ccattctcct gcctcagcct cccgagtagc tgggactaca ggtgcccgcc accatgccca 94140



gctaattttt ttgtatttta tttttttaga gacggggttt caccgtgtta gccaggatgg 94200



tctcgatctc ctgaccttgt gatccgccca ccccggcctc ccaaagtgct gggattacag 94260



gcgtgagcca ctgcgcccgg cctttttttt tttttttttt tttttgagac aaggtctcac 94320



tcccatcacc caggctggcg tgcagtgatg ggatctcgac tcactacagc ctcgacctcc 94380



catgctcagg tgattctgtc acctcagcct gtgtgtagct gggaccacag gtgcacactg 94440



ccatgcttgg ctaattttct gtattttttg cagagacggg gttttgtcat gttgcccagg 94500



ctggtctcaa actcctgggc tcaagtgatc cactcacctt ggcctcccaa agtgctggga 94560



ttataagcat gagccacctc acccagcctg gagacatttt tgattatcac aactgggaag 94620



ggactactgg catctagggg gtacagctgg agatgctgct aaacatccta taattcacag 94680



gacagtctcc cacaacaaag aattatctaa cttaaaatgt caacagtact gaggttgggg 94740



aaaccttgat cc 94752