(en)An effervescent composition is provided which contains a phase-stable oil-in-water emulsion comprising a discontinuous oil phase homogenously distributed within continuous water phase, wherein the discontinuous oil phase comprises a UV-absorbing compound; and from about 20% to about 30% by weight of the composition of a combination of at least two propellants selected from the group consisting of dimethyl ether, a hydrocarbon, or mixtures thereof, and 1, 1-difluoroethane, where the composition includes from about 8% to about 15% by weight of each propellant in the propellant combination, and where the composition provides a phase-stable, effervescent foam when discharged from a pressurized aerosol container.

1.ApplicationNumber: US-201615265237-A
1.PublishNumber: US-2017119642-A1
2.Date Publish: 20170504
3.Inventor: ABEL, Jr. Luis Carlos
DUFORT MARISA
LOPES LUCAS
MIOLLO BRUNA HELENA
RIBEIRO MAYCON
ZAHR ALISAR

4.Inventor Harmonized: ABEL JR LUIS CARLOS(BR)
DUFORT MARISA(US)
LOPES LUCAS(BR)
MIOLLO BRUNA HELENA(BR)
RIBEIRO MAYCON(BR)
ZAHR ALISAR(US)

5.Country: US
6.Claims:
(en)An effervescent composition is provided which contains a phase-stable oil-in-water emulsion comprising a discontinuous oil phase homogenously distributed within continuous water phase, wherein the discontinuous oil phase comprises a UV-absorbing compound; and from about 20% to about 30% by weight of the composition of a combination of at least two propellants selected from the group consisting of dimethyl ether, a hydrocarbon, or mixtures thereof, and 1, 1-difluoroethane, where the composition includes from about 8% to about 15% by weight of each propellant in the propellant combination, and where the composition provides a phase-stable, effervescent foam when discharged from a pressurized aerosol container.

7.Description:
(en)This application claims the benefit of U.S. provisional application 62/248,622 filed on Oct. 30, 2015, the complete contents of which is hereby incorporation herein by reference for all purposes.


The present invention relates to topically-acceptable, sunscreen compositions containing an oil-in-water emulsion comprising a UV-absorbing compound, and a combination of propellants substantially homogeneously distributed there through, which compositions provide a phase-stable, effervescent foam when dispensed from a pressurized aerosol container.
BACKGROUND OF THE INVENTION
The prolonged exposure to UV radiation, such as from the sun, can lead to the formation of light dermatoses and erythemas, as well as increase the risk of skin cancers, such as melanoma, and accelerate skin aging, such as loss of skin elasticity and wrinkling.
Numerous sunscreen compositions are commercially available with varying ability to shield the body from ultraviolet light. Unfortunately, many commercial sunscreens are not effervescent nor having the desirable phase stability to be applied on uneven surfaces or hard to reach areas. Accordingly, sunscreen formulations that are phase-stable, flowable and capable of forming a high volume of vigorous bubbling and effervescence with relatively low energy input are desired by the consumer.
SUMMARY OF THE INVENTION
The present invention provides compositions that include a phase-stable oil-in-water emulsion comprising a discontinuous oil phase homogenously distributed within a continuous water phase, wherein said discontinuous oil phase comprises a UV-absorbing compound; and from about 20% to about 30% by weight of the composition of a combination of at least two propellants. The propellant combination comprises at least two propellants selected from the group consisting of dimethyl ether, a hydrocarbon, or mixtures thereof, and 1, 1-difluoroethane. The compositions comprise from about 8% to about 15% by weight of each propellant included in the propellant combination. The compositions provide a phase-stable, effervescent foam when discharged from a pressurized aerosol container.


DETAILED DESCRIPTION OF THE INVENTION
It is believed that one skilled in the art can, based upon the description herein, utilize the present invention to its fullest extent. The following specific embodiments are to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention belongs. As used herein, unless otherwise indicated, all alkyl, alkenyl, and alkoxy groups may be straight or branched chain groups. As used herein, unless otherwise indicated, the term “molecular weight” refers to weight average molecular weight, (Mw).
Unless defined otherwise, all concentrations refer to concentrations by weight. Also, unless defined otherwise, the term “essentially free of,” with respect to a class of ingredients, refers to the particular ingredient(s) being present in a concentration less than is necessary for the particularly ingredient to be effective to provide the benefit or property for which it otherwise would be used, for example, 0.75% or less by weight, such as about 0.5% or less by weight.
By “effervescent foam”, it is meant a foam dispensed from a pressurized aerosol container, where the foam structure formed exhibits a decrease at least 50% of the height of the foam structure dispensed from the container at one minute after dispensing of the foam from the container. By “phase-stable, effervescent foam”, it is meant an effervescent foam which does not exhibit a noticeable layer of liquid on the surface of the effervescent foam structure, or oily droplets, or lumps in the effervescent foam structure after three months, as determined by the test method described herein.
Propellants
Compositions of the invention include a combination of at least two propellants. In certain embodiments of the invention, the propellant combination includes liquefied and/or dissolved gases immiscible with the carrier of the composition. The liquefied and/or dissolved gases can be retained essentially completely in the liquid phase of the effervescent composition with a slow boiling occurring at temperatures which are significantly higher than the boiling points of the liquefied and/or dissolved gases at the prevailing environmental pressure. Liquefied gases, such as hydrocarbons and 1, 1-difluoroethane, and dissolved gases, such as dimethyl ether, are typically used as propellants for various types of aerosol products contained in aerosol containers. When the pressure is released by means of a valve on the aerosol container, the contents of the pressurized container are discharged and any liquefied and/or dissolved gas propellants discharged from the container vaporize essentially instantaneously as the liquefied and/or dissolved gases enter the much lower pressure zone (i.e., atmospheric pressure) outside of the container.
In certain embodiments of the invention, the liquefied gas propellants are combined with dissolved gas propellants, which also tend to vaporize instantaneously upon release from the pressurized container. The mixture of the liquefied gas propellants and the dissolved gas propellants create high volume of vigorous and relatively long lasting bubbling and effervescence in the composition as discharged. The effervescent compositions are unique in that the effervescent foam formed by the compositions are flowable and easily spreadable when applied and rubbed onto the skin and impart a pleasant cooling sensation.
According to certain embodiments of the invention, the propellant combination is substantially homogeneously distributed through the effervescent composition. Examples of liquefied gas propellants include hydrocarbons, including, but not limited to, pentane, butane, isobutane and propane, and mixtures thereof, and 1, 1-difluoroethane. Examples of mixtures of hydrocarbon propellants include a mixture of 80% butane and 20% propane, based on total weight of the propellant mixture. Examples of dissolved gas propellants are ethers which include, but are not limited to, dimethyl ether. It was surprisingly discovered that, in order to provide phase-stable compositions that provide an effervescent foam when discharged from a pressurized container into atmospheric pressure, the total concentration of the combination of the propellants must be from about 20% to about 30% by weight of the effervescent composition, and the concentration of the selected propellants contained in the propellant combination, including the 80/20 weight percent mixture of butane and propane, must be from about 8% to about 15%. When either condition is not met, the resultant composition either is not phase-stable, or does not provide an effervescent foam when discharged from a pressurized container into atmospheric pressure.
UV-Absorbing Compound
Compositions of the present invention include an ultraviolet radiation-absorbing compound, (i.e., “UV-absorbing compound”). By “UV-absorbing compound,” it is meant a compound comprising one or more UV-absorbing moieties, as discussed herein below, and that absorbs radiation in some portion of the ultraviolet spectrum (290 nm-400 nm), such as one having an extinction coefficient of at least about 1000 mol −1 cm −1 , for example greater than 10,000, or 100,000, or 1,000,000 mol −1 cm −1 , for at least one wavelength within the above-defined ultraviolet spectrum.
In certain embodiments of the invention, the UV-absorbing compound may have low water solubility. For example, in certain embodiments, the UV-absorbing compound may have a water solubility that is about 3% or less by weight, such as about 1% or less by weight. By “water solubility” it is meant the maximum weight percentage of UV-absorbing compound (relative to polymer plus water) that can be placed into 100 grams deionized water and agitated so that a clear solution is obtained and remains visually homogeneous and transparent at ambient temperature for 24 hours.
The UV-absorbing compound includes one or more UV-absorbing moieties. In one particular embodiment, the first ultraviolet-absorbing moiety is a UV-A absorbing moiety. By “UV-A absorbing moiety,” it is meant a moiety that confers appreciable absorbance in the UV-A portion (320 nm to 400 nm) of the ultraviolet spectrum to the UV-absorbing compound. For example, when a compound that includes the UV-absorbing polymer is cast into a film, it is possible to generate a molar extinction coefficient measured for at least one wavelength in this wavelength range of at least about 1000 mol −1 cm −1 , such as at least about 2000 mol −1 cm −1 , such as at least about 4000 mol −1 cm −1 . In one embodiment, the molar extinction coefficient among at least 40% of the wavelengths in this portion of the spectrum is at least about 1000 mol −1 cm −1 .
Examples of moieties that are UV-A absorbing include tertrahydroxybenzophenones; dicarboxydihydroxybenzophenones and alkane ester or acid halide derivatives thereof; dihydroxy-, dicarboxy-, and hydroxycarboxydibenzoylmethanes and alkane ester or acid halide derivatives thereof; dihydroxy-, dicarboxy-, and hydroxycarboxystilbenes and alkane ester or acid halide derivatives thereof; bis(hydroxystyrenyl) benzenes; bis(carboxystyrenyl)benzenes and alkane ester or acid halide derivatives thereof; dihydroxy-, dicarboxy, and hydroxycarboxycarotenes and alkane ester or acid halide derivatives thereof; 2 cyano-3,3-diphenyl acrylic acid, 2-ethyl hexyl ester; and any suitably functionalized species capable of absorbing ultraviolet light in the 320-400 nm range.
In one embodiment, the UV-absorbing moiety is a UV-absorbing triazole and/or a UV-absorbing benzoylmethane. In a particularly notable embodiment, the UV-absorbing moiety is a UV-absorbing triazole.
By “UV-absorbing triazole” it is meant a UV-absorbing moiety containing a five-member heterocyclic ring with two carbon and three nitrogen atoms. UV-absorbing triazoles include, for example, compounds of the formula (II) or (III):









wherein R 14 is an optional C 1 -C 18 alkyl or hydrogen; R 15 and R 22 , independently, are optionally C 1 -C 18 alkyl that may be substituted with a phenyl group, and R 21 is an optional C1-C 8 alkyl. For (II), either of the R 14 , R 15 , or R 21 group may be oriented so as to be directly bonded to the (ester) linking group that connects the UV-absorbing dibenzoylmethane to the C—C backbone. For (III), either of the R 15 or R 22 group may be oriented so as to be directly bonded to the (ester) linking group that connects the UV-absorbing triazole to the C—C backbone.
UV-absorbing dibenzoylmethanes include those that may be represented by formula (IV):









wherein R 19 and R 20 , independently, are optional C1-C 8 alkyl or C 1 -C 8 alkoxy, m 9 is 0 to 3, and m 10 is 1 to 3. Either of the R 19 and R 20 group may be oriented so as to be directly bonded to the (ester) linking group that connects the UV-absorbing dibenzoylmethane to the C—C backbone.
Examples and the synthesis of such non-polymeric dibenzoylmethane moieties are disclosed in U.S. Pat. No. 4,489,057 and include, but are not limited to, 4-(1,1-dimethylethyl)-4′-methoxydibenzoylmethane (avobenzone and sold as PARSOL 1789, Roche Vitamins and Fine Chemicals, Nutley, N.J., USA).
In another embodiment, the ultraviolet-absorbing moiety is a UV-B absorbing moiety. By “UV-B absorbing moiety,” it is meant a moiety that confers appreciable absorbance in the UV-B portion (290 nm to 320 nm) of the ultraviolet spectrum. In one embodiment, the criteria for consideration as a UV-B absorbing moiety is similar to those described above for an UV-A absorbing moiety, except that the wavelength range is 290 nm to 320 nm.
Examples of suitable UV-B absorbing moieties include 4-aminobenzoic acid and alkane esters thereof; anthranilic acid and alkane esters thereof; salicylic acid and alkane esters thereof; hydroxycinnamic acid alkane esters thereof; dihydroxy-, dicarboxy-, and hydroxycarboxybenzophenones and alkane ester or acid halide derivatives thereof; dihydroxy-, dicarboxy-, and hydroxycarboxychalcones and alkane ester or acid halide derivatives thereof; dihydroxy-, dicarboxy-, and hydroxycarboxycoumarins and alkane ester or acid halide derivatives thereof; and other suitably functionalized species capable of absorbing ultraviolet light in the 290-320 nm range.
In certain embodiment of the invention, “UV-absorbing compound” may be an “organic” UV-absorber. Examples of such compounds, sometimes referred to as “monomeric, organic UV-absorbers” include, but are not limited to, methoxycinnamate derivatives such as octyl methoxycinnamate and isoamyl methoxycinnamate; camphor derivatives such as 4-methyl benzylidene camphor, camphor benzalkonium methosulfate, and terephthalylidene dicamphor sulfonic acid; salicylate derivatives such as octyl salicylate, trolamine salicylate, and homosalate; sulfonic acid derivatives such as phenylbenzimidazole sulfonic acid; benzone derivatives such as dioxybenzone, sulisobenzone, and oxybenzone; benzoic acid derivatives such as aminobenzoic acid and octyldimethyl para-amino benzoic acid; octocrylene and other β,β-diphenylacrylates; dioctyl butamido triazone; octyl triazone; butyl methoxydibenzoyl methane; drometrizole trisiloxane; menthyl anthranilate; and bis-ethylhexyloxyphenol methoxyphenyl triazine.
In yet another embodiment of the invention, UV-absorbing compounds may include UV-absorbing particles typically used at least in part to scatter ultraviolet radiation. Examples include inorganic oxides, including titanium dioxide, zinc oxide, iron oxides, silicone oxides, or other metal (e.g., transition metal, such as crystalline transition metal) oxides. Such ultraviolet screening particles are typically solid particles having a diameter from about 0.1 micron to about 10 microns.
It is further desirable that the UV-absorbing compound have an absorbance in the UV spectrum that is sufficiently high so as to make it suitable for use as a sunscreen for the human body. In one embodiment, the compound, when dissolved in a suitable solvent (e.g., DMSO, ethyl acetate, tetrahydrofuran, or the like) and spread or cast into a thin film, has a molar extinction coefficient measured for at least one wavelength within the UV spectrum, such as in the UV-A spectrum, of at least about 1000 mol −1 cm −1 , such as at least about 2000 mol −1 cm −1 , such as at least about 4000 mol −1 cm −1 , or even 10,000 or 100,000 or 1,000,000 mol −1 cm −1 .
A suitable in-vivo test method is the “Colipa Method,” known to those skilled in the art. In this method, the minimum dose of solar-simulated ultraviolet radiation (UVR) required to induce a minimally perceptible erythema on human skin is determined for untreated skin and for the skin treated with the composition (erythema readings taken 24 hours after irradiation). The ratio of the dose of UV radiation needed to induce minimally perceptible erythema for the composition-protected skin (MEDp), divided by the dose required for a minimally perceptible erythema for unprotected skin (MEDu) results in the SPF value of the composition.
An irradiation apparatus used for SPF determinations is, for example, a Multiport Solar Simulator Model 601 (Solar Light Co., Philadelphia, Pa., USA) which consists of a 300 W Xenon lamp filtered with a UG11 1 mm thick filter and a WG320 1 mm filter (Schott Co., Philadelphia, Pa., USA) to allow exposure to UV between 240 and 800 nanometers.
Topical Composition
The effervescent compositions of the present invention may be used for a variety of cosmetic uses, especially for protection of the skin from UV radiation. The composition may be employed for various end-uses, such as recreation or daily-use sunscreens, moisturizers, cosmetics/make-up, cleansers/toners, anti-aging products, or combinations thereof. The compositions of the present invention may be prepared using methodology that is well known by an artisan of ordinary skill in the field of cosmetics formulation.
The compositions include a phase-stable oil-in-water emulsion containing a continuous water phase and a discontinuous oil phase dispersed within the continuous water phase. As used herein, “phase-stable oil-in-water emulsion” means that the water and oil phases of the oil-in-water emulsion do not noticeably separate into two phases. Phase stability of the composition containing the oil-in-water emulsion and propellant combination is determined using a glass chamber, as described herein below. In certain embodiments, the UV-absorbing compound is dissolved, as opposed to being dispersed or suspended, within the oil phase. The oil phase may be such that it is present in discrete droplets or units having an average diameter of about one micron to about 1000 microns, such as from about 1 micron to about 100 microns.
According to the present invention, the water phase may contain from about 0.75% to about 6% by weight of superhydrophilic amphiphilic copolymers and from about 1.0% to about 5% by weight of the non-UV-absorbing light-scattering particles (in suspension form), based on total weight of the composition.
The percentage by weight of water phase included in the compositions may range from about 45% to about 90%, such as from about 55% to about 80%, such as from about 60% to about 80%. The percentage by weight of water in the water phase may be about 90% or more, such as about 95% or more. In certain embodiments the percentage by weight of oil phase in the composition is from about 10% to about 55%, such as from about 20% to about 45%, such as from about 20% to about 40%
According to certain embodiments of the present invention, the oil phase consists essentially of a UV absorbing compound and the oil phase is substantially free of oil soluble polymers. By “substantially free of an oil soluble polymer”, it is meant that the oil phase does not contain an oil soluble polymer at levels that will detrimentally affect the quality of foam generated by the foaming composition, or prevent the foaming composition from forming such foam when applied; for example, about 3% by weight or less, or about 1% by weight or less, or about 0.75% by weight or less. By “Oil soluble polymer” it is meant any polymeric material that is soluble in the oil phase of the composition. Examples of oil soluble polymers include, but are not limited to, a polyamide, e.g. Sylvaclear WF1500V (Polyamide-4), available from Arizona Chemical, an emollient, e.g. siliconyl carnauba wax, commercially available from Koster Keunen Inc., or oil, e.g., a film-forming polymer such as GANEX V216, commercially available from Ashland Specialty Ingredients of Wayne, N.J., and a non-ionic emulsifer such as Myrj-S100, available from Croda Inc. Silicone-based film forming polymers also may be used. In certain embodiment, the oil phase consists essentially of the UV absorbing compound. In certain embodiments, the oil phase contains about 80% or more by weight of the UV absorbing compound, such as greater than 90% by weight of the UV absorbing compound, such as greater than 95% by weight of the UV absorbing compound, such as greater than 97% by weight of the UV absorbing compound, such as greater than 99% by weight of the UV absorbing compound.
In contrast, water soluble or water dispersible polymers may be added to the compositions. The water dispersible polymers are comprised of a water-insoluble polymer that is typically micronized and dispersed into a water carrier, possibly with the use of a surface active dispersing aid. The water dispersible polymeric film formers are capable of forming a film and improving water resistance of the compositions. Examples of water soluble polymers include Polyaldo™ 10-1-L (Polyglyceryl-10 Laurate), available from Lonza. Examples of water dispersible polymeric film formers include water dispersible polyurethanes, such as Baycusan® C1000 (Polyurethane-34), available from Bayer, Dow Corning® 2501 (Bis-PEG-18 Methyl Ether Dimethyl Silane), available from Dow Corning, and Eastman AQ™ 38 S (Polyester-5), available from Eastman Chemical.
In one embodiment, a composition suitable for topical/cosmetic use for application to the human body (e.g., keratinaceous surfaces such as the skin or hair), especially the skin, is provided. The composition includes one or more UV-absorbing compound described herein. In certain embodiments the concentration by weight of UV-absorbing compound in the composition is about 10% to about 50% by weight, such as from about 15% to about 40% by weight, such as from about 15% to about 35% by weight, such as from about 20% to about 30% by weight.
In certain embodiments the composition may include one or more compounds suitable for enhancing photostability. Photostabilizers include, for example, diester or polyesters of a naphthalene dicarboxylic acid.
Carrier
The composition may be combined with a “cosmetically-acceptable topical carrier,” i.e., a carrier for topical use that is capable of having the other ingredients dispersed or dissolved therein, and possessing acceptable properties rendering it safe to use topically. As such, the composition may further include any of various functional ingredients known in the field of cosmetic chemistry, for example, emollients, as well as other ingredients commonly used in personal care compositions such as humectants, e.g., glycerin, thickeners, opacifiers, fragrances, dyes, solvents for the UV-absorbing compound, among other functional ingredients. In order to provide pleasant aesthetics, in certain embodiments of the invention, the composition is substantially free of volatile solvents, and, in particular C 1 -C 4 alcohols such as ethanol and isopropanol.
Furthermore, the composition may be essentially free of ingredients that would render the composition unsuitable for topical use. As such, the composition may be essentially free of solvents such as volatile solvents, and, in particular, free of volatile organic solvents such as ketones, xylene, toluene, and the like. Further the composition may be essentially free of, or free of, propellant gas, such as hydrocarbon gases, including dimethyl ether.
Oil-in-Water Emulsifier
Compositions of the present invention include one or more oil-in-water (O/W) emulsifiers selected from a group consisting of anionic emulsifiers and non-ionic emulsifiers. By “emulsifier,” it is meant any of a variety of molecules that are suitable for emulsifying discrete oil-phase droplets in a continuous water phase. By “low molecular weight emulsifiers,” it is meant emulsifiers having a molecular weight of about 2000 daltons or less, such as about 1000 daltons or less. The O/W emulsifier may be capable of lowering the surface tension of pure deionized water to 45 dynes per centimeter when added to pure deionized water at a concentration of O/W emulsifier of 0.5% or less by weight at room temperature. The O/W emulsifier may have a hydrophile-lipophile balance (HLB) that is about 8 or more, such as about 10 or more. Alternatively, the O/W emulsifier may be HLB independent. Such O/W emulsifiers contain thickeners. Examples include but not limited to Steareth-100; Steareth-2; mannan; xanthan gum.
Furthermore, the compositions of the present invention are essentially free of, or free of, monomeric surfactant. By “monomeric surfactants” it is meant any surface active agent that is monomeric. The monomeric surfactants may be anionic, nonionic, amphoteric or cationic.
In certain embodiments, the composition may include less than 10% by weight, or less than 2% by weight, of an emollient used for the prevention or relief of dryness and for the protection of the skin, as well as solubilizing the UV-absorbing compound. Suitable emollients include mineral oils, petrolatum, vegetable oils (e.g. triglycerides such as caprylic/capric triglyceride), waxes and other mixtures of fatty esters, including but not limited to esters of glycerol (e.g, isopropyl palmitate, isopropylmyristate), and silicone oils such as dimethicone. In certain embodiments, mixtures of triglycerides (e.g. caprylic/capric triclycerides) and esters of glycols (e.g. isopropyl myristate) may be used to solubilize the UV-absorbing compounds. In other embodiments of the invention, the compositions are essentially free of, or free of, emollients.
In certain embodiments, the composition includes a pigment suitable for providing color or hiding power. The pigment may be one suitable for use in a color cosmetic product, including compositions for application to the hair, nails and/or skin, especially the face. Color cosmetic compositions include, but are not limited to, foundations, concealers, primers, blush, mascara, eyeshadow, eyeliner, lipstick, nail polish and tinted moisturizers. The pigment suitable for providing color or hiding power may be composed of iron oxides, including red and yellow iron oxides, titanium dioxide, ultramarine and chromium or chromium hydroxide colors, and mixtures thereof. The pigment may be a lake pigment, e.g., an organic dye such as azo, indigoid, triphenylmethane, anthraquinone, and xanthine dyes that are designated as D&C and FD&C blues, browns, greens, oranges, reds, yellows, etc., precipitated onto inert binders such as insoluble salts. Examples of lake pigments include Red #6, Red #7, Yellow #5 and Blue #1. The pigment may be an interference pigment. Examples of interference pigments include those containing mica substrates, bismuth oxycloride substrates, and silica substrates, for instance mica/bismuth oxychloride/iron oxide pigments commercially available as CHROMALITE pigments (BASF), titanium dioxide and/or iron oxides coated onto mica such as commercially available FLAMENCO pigments (BASF), mica/titanium dioxide/iron oxide pigments including commercially available KTZ pigments (Kobo products), CELLINI pearl pigments (BASF), and borosilicate-containing pigments such as REFLECKS pigments (BASF).
The compositions of the present invention may further comprise one or more other cosmetically active agent(s). A “cosmetically active agent” is a compound that has a cosmetic or therapeutic effect on the skin, e.g., agents to treat wrinkles, acne, or to lighten the skin. The cosmetically active agent will typically be present in the composition of the invention in an amount of from about 0.001% to about 20% by weight of the composition, e.g., about 0.01% to about 10% by weight, such as about 0.1% to about 5% by weight of the composition.
The compositions of the present invention can be used by topically administering the effervescent foam to a mammal, e.g., by the direct laying on, wiping or spreading of the effervescent foam on the skin or hair of a human.
EXAMPLES
The following examples illustrate the preparation and efficacy of compositions of the present invention.
Example I Measurement of Effervescence and Phase Stability
The following example illustrates the effervescence and phase stability of certain compositions of the present invention. Inventive Examples E1 through E9 as shown in Tables 1 and 2 were made by the following process:
The compositions of the present invention were prepared using mixing and blending methodology that is well known by an artisan of ordinary skill. In one embodiment of the invention, an oil phase is prepared by mixing at least the UV-absorbing compound with optional oil soluble or oil-miscible ingredients. The water phase is prepared by mixing water and optional water-soluble or water-miscible ingredients together. The oil phase and the water phase are then mixed in a manner sufficient to disperse the oil phase substantially homogeneously in the water phase, such that the water phase is continuous and the oil phase discontinuous.
Comparative Examples C1 and C7 as shown in Table 3 were prepared by the process as described above.
Phase Stability/Effervescent Test:
Phase stability and effervescence of the effervescent foam was determined as described below.
Multiple samples of each composition to be bested were prepared by filling glass containers with each mixture of the oil-in-water emulsion comprising a UV-absorbing compound and selected propellants, at selected concentrations, to be tested. The samples in the glass containers were placed under pressure of 5-6 bars and 7-8 bars, depending on test conditions described herein below, and maintained at room temperature for 24 hours. Twenty four hours after filling, the glass containers containing each sample were then placed in a water bath at 25±1° C., for 45 minutes. The samples were then removed from the water bath and a foam was discharged from each pressurized container to form a foam structure having a substantially circular base and a height from the base to the top of the foam structure of about 0.5 cm. Each foam structure was then visually observed to determine any noticeable phase separation. Noticeable phase separation is indicated by formation of a liquid layer on the surface of the foam structure, or the formation of oil droplets or visible lumps in the foam structure.
The height from the base of the foam structure to the surface of the foam structure also was measured, both at the time the foam structure was discharged from the pressurized container, and again one minute after the foam structure was discharged from the pressurized container. A decrease in the height of the foam body over time is an indication that bubbles formed in the foam body upon discharge are rapidly rupturing as the propellant is released from the foam body, indicating an effervescent foam. No change, or negligible change, in the height of the foam body is an indication that bubbles formed in the foam are not rupturing as fast as the effervescent foam, which is an indication that the foam is not effervescent.
Half of the samples under 5-6 bars pressure were placed in an environmental chamber set at 5° C., while the other half of samples under 5-6 bars pressure were placed in an environmental chamber set at 25° C. Samples under 7-8 bars pressure were placed in an environmental chamber set at 45° C. The samples were maintained at the respective temperature for three months. After three months, samples were removed from the environment chambers and maintained at room temperature for 24 hours. The samples were then placed in a water bath at 25±1° C., for 45 minutes. The samples were then removed from the water bath and a foam was discharged from each pressurized container to form a foam structure as described above. Each foam structure was then visually observed to determine any noticeable phase separation and the height of the foam structure both upon discharge of the foam structure from the container and one minute after discharge of the foam structure was measured.
For comparative examples C1-C7, there was no noticeable decrease in the height of the foam body after one minute. For Inventive Examples E1-E9, there was a decrease of at least 50% of the height of the foam body, and in some instances as much as an 80% decrease in the height of the foam body, e.g., the height of the foam structure decreased from 0.5 cm to 0.1 cm after one minute.





TABLE 1



Formulation of the Inventive Examples





Examples









E1
E2
E3

Trade name
Ingredient (INICI Name)
%
%
%









Dimethyl Ether
Dimethyl Ether
10.00
15.00
0

Butane/Propane (80/20)
Butane/Propane
10.00
10.00
10

Isobutane
Isobutane
0
0
0

152A
1,1-difluoroethane
0
0
10

Concentrate
Formula Lotion
80.00
75.00
80

Purified Water
Water
56.400
56.400
56.400

Versaflex V-150-PW-
Steareth-100; Steareth-2; Xanthan
1.500
1.500
1.500

MW
Gum; Mannan

Disodium EDTA
Disodium EDTA
0.200
0.200
0.200

Elestab CPN
Chlorphenesin
0.000
0.000
0.000

Tristat P25/
Phenoxyethanol
0.500
0.500
0.500

Phenoxyethnaol P25

Symsave H
Hydroxyacetophenone
0.500
0.500
0.500

Hydrolite 5
Pentylene Glycol
1.000
1.000
1.000

Structure XL
Hydroxypropyl Startch Phosphate
0.750
0.750
0.750

Neo Heliopan 303
Octocrylene
8.000
8.000
8.000

Finsolv TN
C 12-15 Alkyl Benzoate
5.000
5.000
5.000

Neo Heliopan OS
Ethylhexyl Salicylate
4.500
4.500
4.500

Neo Heliopan 357 (US
Avobenzone
2.700
2.700
2.700

Sunscreen Active)

Sunspheres Powder
Styrene/Acrylates Copolymer
2.500
2.500
2.500

Neo Heliopan HMS
Homosalate
9.000
9.000
9.000

Neo Heliopan BB
Benzophenone-3
4.500
4.500
4.500

X-22 8247-D
Dimethicone; Acrylates/Dimethicone
1.200
1.200
1.200


Copolymer

Vitamin E Acetate
Tocopheryl Acetate
0.100
0.100
0.100

SymCalriol 344028
Decylene Glycol
0.150
0.150
0.150

Abil Wax 9801
Cetyl Dimethicone
0.500
0.500
0.500

Fragrance
Fragrance
0.050
0.050
0.050

Silisphere 6M
Silica
1.000
1.000
1.000






TOTAL
100
100
100

Effervescence Performance
Yes
Yes
Yes

Phase Stability
Yes
Yes
Yes
































































As shown in Table 1, Inventive examples E1, E2 and E3 exhibit superior effervescence performance and phase stability.





TABLE 2



Formulation of the Inventive Examples





Examples












E4
E5
E6
E7
E8
E9

Trade name
Ingredient (INICI Name)
%
%
%
%
%
%












Dimethyl Ether
Dimethyl Ether
8.000
12.00
10.00
15.00
10.00
15.00

Butane/Propane (80/20)
Butane/Propane
12.000
8.00
10.00
15.00

Isobutane
Isobutane




10.00
10.00

Pemulen TR1
Acrylates/C 10-30 Alkyl
0.160
0.160
0.160
0.140
0.160
0.15


Acrylate Crosspolymer

EDTA DISSODIUM
EDTA DISSODIUM
0.160
0.160
0.160
0.140
0.160
0.15

Chlorphenesin
ELESTAB CPN
0.200
0.200
0.200
0.175
0.200
0.1875

SODIUM
SODIUM HYDROXYDE
0.024
0.024
0.024
0.021
0.024
0.0225

HYDROXYDE (50%)

Sunspheres Powder
Styrene/Acrylates
2.000
2.000
2.000
1.750
2.000
1.875


Copolymer

Neo Heliopan 303
Octocrylene
7.200
7.200
7.200
6.300
7.200
6.75

Finsolv TN
C 12-15 Alkyl Benzoate
4.000
4.000
4.000
3.500
4.000
3.75

NEO HELIOPAN OS
ETHYLHEXYL
3.600
3.600
3.600
3.150
3.600
3.375


SALICYLATE

Parsol 1789
Butyl
3.200
3.200
3.200
2.800
3.200
3


Methoxydibenzoylmethane

Tinosorb S
Bis-Ethylhexyloxyphenol
2.000
2.000
2.000
1.750
2.000
1.875


Methoxyphenyl Triazine

ISOPROPYL
PRISORINE 2021/
1.600
1.600
1.600
1.400
1.600
1.5

ISOSTEARATE
CRODAMOL IPIS -LQ-


(MV)

Butylene Glycol
Butylene Glycol
1.600
1.600
1.600
1.400
1.600
1.5

AMPHISOL K
Cetyl Phosphate Potassium
1.600
1.600
1.600
1.400
1.600
1.5

ARLACEL 987
Cera Alba; Hydrogenated
1.280
1.280
1.280
1.120
1.280
1.2


Castor Oil; Sorbitan


Isostearate; Stearic Acid

Antaron WP-660
Triacontanyl PVP
1.200
1.200
1.200
1.050
1.200
1.125

Phenoxyethanol
Phenoxyethanol
0.560
0.560
0.560
0.490
0.560
0.525

TRIBEHENIN
SYNCROWAX HR-C
0.400
0.400
0.400
0.350
0.400
0.375

SILSOFT-034
CAPRYLYL
0.160
0.160
0.160
0.140
0.160
0.15


METHYCONE

Vitamin E Acetate
Tocopheryl Acetate
0.080
0.080
0.080
0.070
0.080
0.075

Tinogard TT
Pentaerythrityl
0.040
0.040
0.040
0.035
0.040
0.0375


Tetra-di-t-butyl


Hydroxyhydrocinnamate

Frecolat ML
Menthyl Lactate
0.008
0.008
0.008
0.007
0.008
0.0075

Fragrance Zen 486213
Parfum
0.280
0.280
0.280
0.245
0.280
0.2625

Benzyl alcohol
Benzyl Alcohol
0.640
0.640
0.640
0.560
0.640
0.6

SEPITONIC M3
Magnesium Aspartate/
0.008
0.008
0.008
0.007
0.008
0.0075


Zinc Gluconate/Copper


Gluconate

Dow Corning CF-4444
Dimethicone/Trisiloxane
2.400
2.400
2.400
2.100
2.400
2.25

Fluid

Extrapone ® Green
Water; Camellia Sinensis
0.008
0.008
0.008
0.007
0.008
0.0075

Tea/Propolis 400140
Leaf Extract; Propolis


Extract; Propylene Glycol

DRY FLO PURE
Aluminum Starch
0.400
0.400
0.400
0.350
0.400
0.375


Octenylsuccinate

Purified Water
Aqua
45.192
45.192
45.192
39.543
45.192
42.3675









TOTAL
100
100
100
100
100
100

Effervescence Performance
Yes
Yes
Yes
Yes
Yes
Yes

Phase Stability
Yes
Yes
Yes
Yes
Yes
Yes




















































































As shown in Table 2, Inventive examples E4 to E9 exhibit superior effervescence performance and phase stability.





TABLE 3



Formulation of the Comparative Examples





Comparative













C1
C2
C3
C4
C5
C6
C7

Trade name
Ingredient (INCI Name)
%
%
%
%
%
%
%













Dimethyl Ether
Dimethyl Ether
10.00



30.00

10.00

Butane/Propane
Butane/Propane





30.00
20.00

(80/20)

Isobutane
Isobutane

10.00
30.00
8.00

Pemulen TR1
Acrylates/C 10-30 Alkyl
0.180
0.180
0.140
0.184
0.140
0.140
0.140


Acrylate Crosspolymer

EDTA
EDTA DISSODIUM
0.180
0.180
0.140
0.184
0.140
0.140
0.140

DISSODIUM

Chlorphenesin
ELESTAB CPN
0.225
0.225
0.175
0.230
0.175
0.175
0.175

SODIUM
SODIUM HYDROXYDE
0.027
0.027
0.021
0.028
0.021
0.021
0.021

HYDROXYDE (50%)

Sunspheres Powder
Styrene/Acrylates
2.250
2.250
1.750
2.300
1.750
1.750
1.750


Copolymer

Neo Heliopan 303
Octocrylene
8.100
8.100
6.300
8.280
6.300
6.300
6.300

Finsolv TN
C 12-15 Alkyl Benzoate
4.500
4.500
3.500
4.600
3.500
3.500
3.500

NEO HELIOPAN
ETHYLHEXYL
4.050
4.050
3.150
4.140
3.150
3.150
3.150

OS
SALICYLATE

Parsol 1789
Butyl
3.600
3.600
2.800
3.680
2.800
2.800
2.800


Methoxydibenzoylmethane

Tinosorb S
Bis-Ethylhexyloxyphenol
2.250
2.250
1.750
2.300
1.750
1.750
1.750


Methoxyphenyl Triazine

ISOPROPYL
PRISORINE 2021/
1.800
1.800
1.400
1.840
1.400
1.400
1.400

ISOSTEARATE
CRODAMOL IPIS -LQ-


(MV)

Butylene Glycol
Butylene Glycol
1.800
1.800
1.400
1.840
1.400
1.400
1.400

AMPHISOL K
Cetyl Phosphate Potassium
1.800
1.800
1.400
1.840
1.400
1.400
1.400

ARLACEL 987
Cera Alba; Hydrogenated
1.440
1.440
1.120
1.472
1.120
1.120
1.120


Castor Oil; Sorbitan


Isostearate; Stearic Acid

Antaron WP-660
Triacontanyl PVP
1.350
1.350
1.050
1.380
1.050
1.050
1.050

Phenoxyethanol
Phenoxyethanol
0.630
0.630
0.490
0.644
0.490
0.490
0.490

TRIBEHENIN
SYNCROWAX HR-C
0.450
0.450
0.350
0.460
0.350
0.350
0.350

SILSOFT-034
CAPRYLYL
0.180
0.180
0.140
0.184
0.140
0.140
0.140


METHYCONE

Vitamin E
Tocopheryl Acetate
0.090
0.090
0.070
0.092
0.070
0.070
0.070

Acetate

Tinogard TT
Pentaerythrityl
0.045
0.045
0.035
0.046
0.035
0.035
0.035


Tetra-di-t-butyl


Hydroxyhydrocinnamate

Frecolat ML
Menthyl Lactate
0.009
0.009
0.007
0.009
0.007
0.007
0.007

Fragrance Zen
Parfum
0.315
0.315
0.245
0.322
0.245
0.245
0.245

486213

Benzyl alcohol
Benzyl Alcohol
0.720
0.720
0.560
0.736
0.560
0.560
0.560

SEPITONIC
Magnesium Aspartate/
0.009
0.009
0.007
0.009
0.007
0.007
0.007

M3
Zinc Gluconate/


Copper Gluconate

Dow Corning
Dimethicone/
2.700
2.700
2.100
2.760
2.100
2.100
2.100

CF-4444 Fluid
Trisiloxane

Extrapone ®
Water; Camelli a
0.009
0.009
0.007
0.009
0.007
0.007
0.007

Green
Sinensis Leaf Extract;

Tea/Propolis
Propolis Extract;

400140
Propylene Glycol

DRY FLO
Aluminum Starch
0.450
0.450
0.350
0.460
0.350
0.350
0.350

PURE
Octenylsuccinate

Purified Water
Aqua
50.841
50.841
39.543
51.971
39.543
39.543
39.53

DI water
Water











TOTAL
100
100
100
100
100
100
100

Effervescence Performance
No
No
No
No
Yes
Yes
Yes

Phase Stability
Yes
Yes
Yes
Yes
No
No
No


























































































As shown in Table 3, Comparative examples (C1 to C7) exhibit either poor effervescence performance or phase stability.





TABLE 4



Formulation of the Comparative Examples





Comparative









C8
C9
C10

Trade name
Ingredient (INCI Name)
%
%
%









Dimethyl Ether
Dimethyl Ether
0
0
0

Butane/Propane (80/20)
Butane/Propane
0
0
0

Isobutane
Isobutane
10.00
30.00
8.00

Concentrate
Formula Lotion
90.00
70.00
92.00

Purified Water
Water
54.800
54.800
54.800

Versaflex V-150-PW-
Steareth-100; Steareth-2;
1.000
1.000
1.000

MW
Xanthan Gum; Mannan

Disodium EDTA
Disodium EDTA
0.200
0.200
0.200

Elestab CPN
Chlorphenesin
0.250
0.250
0.250

Tristat P25/
Phenoxyethanol
0.700
0.700
0.700

Phenoxyethnaol P25

Symsave H
Hydroxyacetophenone
0.000
0.000
0.000

Hydrolite 5
Pentylene Glycol
0.000
0.000
0.000

Structure XL
Hydroxypropyl Startch
0.750
0.750
0.750


Phosphate

Neo Heliopan 303
Octocrylene
8.000
8.000
8.000

Finsolv TN
C 12 - 15 Alkyl Benzoate
5.000
5.000
5.000

Neo Heliopan OS
Ethylhexyl Salicylate
4.500
4.500
4.500

Neo Heliopan 357 (US
Avobenzone
2.700
2.700
2.700

Sunscreen Active)

Sunspheres Powder
Styrene/Acrylates Copolymer
5.500
5.500
5.500

Neo Heliopan HMS
Homosalate
9.000
9.000
9.000

Neo Heliopan BB
Benzophenone-3
4.500
4.500
4.500

X-22 8247-D
Dimethicone; Acrylates/
1.200
1.200
1.200


Dimethicone Copolymer

Vitamin E Acetate
Tocopheryl Acetate
0.100
0.100
0.100

SymCalriol 344028
Decylene Glycol
0.150
0.150
0.150

Xiameter PMX-1184
Dimethicone; Trisiloxane
0.500
0.500
0.500

Silicone Fluid

Intense Heat
Fragrance
0.150
0.150
0.150

Silisphere 6M
Silica
1.000
1.000
1.000






TOTAL
100
100
100

Effervescence Performance
No
No
No

Phase Stability
Yes
Yes
Yes

































































As shown in Table 4, Comparative examples C8 to C10 exhibit poor effervescence performance.