(en)The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.

1.ApplicationNumber: US-201815877470-A
1.PublishNumber: US-2018180391-A1
2.Date Publish: 20180628
3.Inventor: HOLLAND, LYNETTE ANNE MAKINS
BONNET, CHRISTELLE MARIE SANDRINE
PASTOR, FABIENNE
VELAZQUEZ MENDOZA, JOSE MARIA
STONEHOUSE, JONATHAN RICHARD
STAITE, WILLIAM EOGHAN
STANTON, DAVID THOMAS
TODINI, ORESTE
SCHOFIELD, STEPHEN ROBERT
NYAKANA, SARAH KYAKYO KANYUNYUZI
FERNANDEZ PRIETO, SUSANA
SMETS, JOHAN
SCHEIBEL, JEFFREY JOHN
Guimet, Isabelle

4.Inventor Harmonized: HOLLAND LYNETTE ANNE MAKINS(GB)
BONNET CHRISTELLE MARIE SANDRINE(FR)
PASTOR FABIENNE(FR)
VELAZQUEZ MENDOZA JOSE MARIA(GB)
STONEHOUSE JONATHAN RICHARD(GB)
STAITE WILLIAM EOGHAN(GB)
STANTON DAVID THOMAS(US)
TODINI ORESTE(BE)
SCHOFIELD STEPHEN ROBERT(GB)
NYAKANA SARAH KYAKYO KANYUNYUZI(GB)
FERNANDEZ PRIETO SUSANA(ES)
SMETS JOHAN(BE)
SCHEIBEL JEFFREY JOHN(US)
GUIMET ISABELLE(BE)

5.Country: US
6.Claims:
(en)The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.

7.Description:
(en)FIELD OF THE INVENTION
The present invention relates to the field of perfumery. In particular, it provides compositions comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator for improving or enhancing the fidelity and/or longevity of the fragrance profile. The invention also relates to methods of making and using said compositions.
BACKGROUND OF THE INVENTION
Conventional perfuming compositions have a fragrance profile characterized by the classical fragrance pyramid three-tiered structure, which contains a higher amount of the base notes, a medium amount of the heart notes, and a lower amount of the top notes (see FIG. 1 a ). The conventional pyramid structure is used because higher levels of the base notes are relied upon to provide the intensity of the overall fragrance profile over time and replace the heart notes when those are declining. Simply increasing the levels of heart and top notes does not provide the required longevity because of their fast evaporation.
Perfumers typically classify fragrance materials as a base, heart or top note according to their specific characters. For instance, the fragrance material “Hedione®” (or also known as “methyl dihydrojasmonate”) is commonly classified as a heart note based on its perceived floral character. However, due to the somewhat subjective nature of characters, there has been no universal convention for objectively classifying fragrance materials. As a result of the subjective classification approach, fragrance formulation has been inconsistent. For example, two compositions having the exact same classification of fragrance materials constructed according to the classical fragrance pyramid structure could have two different, possibly very different, fragrance profiles.
With the classical fragrance pyramid structure, “base notes” make up from greater than 30 wt %, typically greater than 40 wt % or typically greater than 50 wt %, relative to the total weight of the perfume formulation. Base notes are characterized by providing animalic, woody, sweet, amber or musky characters, and not being very volatile. The “heart or middle notes”, make up from about 0.1 wt % to about 60 wt % relative to the total weight of the perfume formulation and have an intermediate volatility. Heart notes are associated with desirable characters such as floral characters (e.g., jasmin, rose), fruity, marine, aromatic or spicy characters. The “top or head notes” provide citrusy, green, light, or fresh characters, and make up from about 0.1 wt % to about 40 wt % relative to the total weight of the perfume formulation. Top notes tend to evaporate quickly due to their high volatility.
There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain “fragrance profile fidelity” over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the classical fragrance pyramid construction, the possible types of fragrance profiles have been somewhat limited. The consequence of using base notes at high levels is that many fragrance dry-downs appear repetitive, boring, non-memorable and un-interesting to consumers. However, if base notes are reduced or excluded then the fragrance intensity weakens over time and does not last for a sufficient duration. Lastly, it is generally accepted that some consumers desire prolonged intensity of select characters, particularly the floral, spicy or aromatic characters derived from the heart notes. Unfortunately, the consequence of using high levels of base notes is that they may impart particularly undesirable characters, such as for example, musky, woody, ambery, warm and sweet, which overpower and dominate the more desirable fragrance characters over time, particular over long periods of time. Thus, the unique challenge remains of selectively extending the more desirable characters attributable from the heart and/or top notes, particularly the heart notes, and even more particularly extending these desirable characters over long periods of time.
Previous attempts to overcome these problems have been through the use of various “fixatives” or “modulators” to retard the evaporation of the more volatile fragrance ingredients present in fragrance compositions. For instance, U.S. Pat. No. 6,737,396B2 (Firmenich) describes a perfume composition formed by mixing 2-30%, relative to the weight of the composition, of a fixative, (1-ethoxyethoxy)cyclododecane, to fix or exalt the musky or aromatic-type notes. U.S. Pat. No. 6,440,400B1 (Takasago Perfumery) describes a composition using trimethylcyclohexane derivatives as perfuming-holding agents and melanin-formation inhibitors. U.S. Pat. No. 4,313,855 (Dragoco) describes the use in cosmetic compositions of 1-(2,6,6-trimethylcyclohexyl)-hexane-3-ol as an odourless fixative for increasing the perfume's intensity. U.S. Pat. No. 6,147,049 (Givaudan) discloses a perfume fixative derived from tera-hydronaphthalenese for use in a wide range of fragrance compositions. WO85/04803 (Diagnostica) describes the use of hyaluronic acid/hyaluronate as fixatives (via molecular encapsulation) in fragrance products to improve persistent of the fragrance. JP Patent No. 61-083114 (Kanebo) describes ether derivatives as aroma-preserving agent for fine perfume composition. JP Patent No. 61-063612 (Kanebo) discloses diethylene glycol ether derivatives as fragrance adjusting agent showing effects as a fixative and a solubilizer. JP Patent No. 62-084010 (Shiseido) describes hydroquinone glycoside as perfume fixatives applicable for all kinds of perfume and blended perfume. U.S. Pat. No. 7,196,052 (Takasago Int. Corp.) describes fragrance compositions containing glycerol ether derivatives as fixatives or fragrance note-improving agent. EP Patent Publication No. 616800A2 (Givaudan) discloses odourant compositions containing panethenol ethyl ether having improved prolonged diffusion of the perfume materials from the skin, without notably modifying the olfactive note of the product. U.S. Pat. No. 4,110,626 (Shiseido) describes the use of aliphatic dibasic acid diester as “perfume controlling agent” for improved fixing effect on fragrance component. PCT Publication No. WO2014/155019 (LVMH) describes aliphatic ether derivatives to increase the stability of alcoholic fragrance composition and more particularly to preserve the original olfactive notes.
These attempts have advocated the use of such fixatives or modulators indiscriminately without regard to the fragrance profile. Further, these attempts do not teach how to objectively classify the fragrance materials as low, moderate or high volatile fragrance materials. Further, the use of fixatives or modulators in these attempts often shows effects on single fragrance material, which are often not observed in a fragrance composition of a mixture of fragrance materials where a number of such fragrance materials are competing with each other to interact with said fixatives or modulators. They do not teach how to formulate with fixatives or modulators in fragrance mixtures, which is not trivial. As a result, these attempts, while disclosing compositions that retain the perfume by way of fixatives or modulators, neither teach the fragrance diamond construction in compositions nor the particular type or levels of fragrance materials to include for delivering the benefits of improved fidelity to the perceived fragrance profile over time, or improved longevity of the fragrance profile, preferably the characters attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance materials.
On the other hand, other attempts propose a selective approach aimed at the selection of specific fixatives or modulators and defined amounts of fragrance materials. For instance, U.S. Pat. No. 7,538,081 (Takasago Perfumery) approaches the problem of fixing a perfume and/or extending the perfume release from a fragrance composition. More particularly, said document describes the use of L-menthoxy ether derivatives as fixatives in fragrance compositions comprising at least one note selected from: floral, citrus, fruity, green, mint, herb and marine. U.S. Patent Publication No. 2011/0104089A1 (Symrise) describes certain compositions containing neopentyl glycol diisononanoate as a fixative for top note perfume oils by increasing their adhereance to skin and hair. U.S. Patent Publication No. 2011/0091404 (Symrise) discloses the use of N-hexadecyl n-nonanoate and N-octadecyl n-nonanoate as fixatives of fragrance substances, particularly the readily volatile top notes, by lowering their vapor pressure to allow for a time-delayed release of the perfume oil components from a composition.
However, these attempts tend not to describe how to formulate with fixatives or modulators in complex mixtures of fragrance materials. For those references that do describe mixtures of fragrance materials, they have different fragrance design criteria and are directed to specific preferred fixatives or modulators.
SUMMARY OF THE INVENTION
The inventors have discovered new rules for objectively classifying fragrance materials according to their vapor pressures into low, moderate and high volatile fragrance materials for formulating into fragrance mixtures, preferably complex mixtures having a diamond construction.
In a first aspect, the present invention is directed to a composition comprising a diamond construction fragrance formulation (see FIG. 1 b ) and at least one substantially non-odorous fragrance modulator for delivering enhanced intensity of the perceived fragrance profile over time, preferably the components attributable from the moderate and high volatile fragrance materials. In particular, the present invention is directed to a composition comprising: (i) a fragrance component present in an amount of from about 0.04 wt % to about 30 wt %, relative to the total weight of the composition; (ii) at least one substantially non-odorous fragrance modulator present in the amount of from about 0.1 wt % to about 20 wt %, relative to the total weight of the composition; (iii) a volatile solvent present in an amount of from about 50 wt % to about 80 wt %, relative to the total weight of the composition; and (iv) optionally water. The fragrance component comprises: (a) at least one low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C. present in an amount of from about 10 wt % to about 30 wt %, relative to the total weight of the fragrance component; (b) at least one moderate volatile fragrance material having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C. present in an amount of from about 40 wt % to about 80 wt %, relative to the total weight of the fragrance component; and (c) at least one high volatile fragrance material having a vapor pressure greater than 0.1 Torr (0.0133 kPa) at 25° C. present in an amount of from about 1 wt % to about 30 wt %, relative to the total weight of the fragrance component.
In another aspect, the present invention is directed to a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair with the composition of the present invention.
Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositions having improved longevity of the perceived fragrance profile, preferably the characters attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance material. It is yet a further advantage to provide compositions having stable quality of end product (e.g., fragrance profile, visual appearance) substantially comparable to the classical fragrance pyramid three-tiered structure, preferably even after three months storage at 40° C. It is yet a further advantage to be able to create new to the world fragrance profiles wherein one, or several, well-recognized moderate volatile fragrance material characters, are maintained over time, preferably for long periods of time (e.g., greater than 4, 6, or even 8 hours).
These and other features of the present invention will become apparent to one skilled in the art upon review of the following detailed description when taken in conjunction with the appended claims.



BRIEF DESCRIPTION OF THE DRAWINGS
While the specification concludes with claims particularly pointing out and distinctly claiming the invention, it is believed that the invention will be better understood from the following description of the accompanying figures wherein:
FIG. 1 a is a diagram of the classical fragrance pyramid structure of the prior art.
FIG. 1 b is a diagram of a fragrance diamond construction according to an embodiment of the present invention.
FIG. 2 provides the panel test results of perceived fragrance profile, particularly improved fragrance profile longevity of Composition A9 comprising Indocolore fragrance material and Expert Gel® 56 substantially non-odorous fragrance modulator as compared to Composition B9, a control absent of a substantially non-odorous fragrance modulator (Expert Gel® 56), and as a function of time elapsed since application of the composition.
FIG. 3 provides the panel test results of perceived fragrance profile, particularly improved fragrance profile longevity of Composition C9 comprising Dimethyl Benzyl Carbinol fragrance material and Kolliphor® EL substantially non-odorous fragrance modulator as compared to Composition D9, a control absent of a substantially non-odorous fragrance modulator (Kolliphor® EL), and as a function of time elapsed since application of the composition.
FIG. 4 provides the panel test results of perceived fragrance profile, particularly improved fragrance profile longevity of Composition E9 comprising Eugenol fragrance material and Kolliphor® EL substantially non-odorous fragrance modulator as compared to Composition F9, a control absent of a substantially non-odorous fragrance modulator (Kolliphor® EL), and as a function of time elapsed since application of the composition.
FIG. 5 provides the panel test results of perceived fragrance profile, particularly improved fragrance profile longevity of Composition G9 comprising Phenethyl alcohol (PEA) fragrance material and Kolliphor® EL substantially non-odorous fragrance modulator as compared to Composition H9, a control absent of a substantially non-odorous fragrance modulator (Kolliphor® EL), and as a function of time elapsed since application of the composition.
FIG. 6 provides the panel test results of the fragrance profile longevity, particularly intensity of the character attributable to the volatile fragrance materials, of Composition A4 comprising Diamond Floral Magnifica Fragrance Example 4b, and PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) substantially non-odorous fragrance modulator as compared to Composition C4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 7 provides the panel test results of the fragrance profile longevity, particularly intensity of the character attributable to the volatile fragrance materials, of Composition A4 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) substantially non-odorous fragrance modulator as compared to Composition C4, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 8 provides the panel test results of the fragrance profile longevity, particularly intensity of the character attributable to the volatile fragrance materials, of Composition A2 comprising Diamond Floral Magnifica Fragrance Example 4b, and Diisobutyl Adipate substantially non-odorous fragrance modulator as compared to Composition C2, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 9 provides the panel test results of the fragrance profile longevity, particularly intensity of the character attributable to the volatile fragrance materials, of Composition A2 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and Diisobutyl Adipate substantially non-odorous fragrance modulator as compared to Composition C2, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 10 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition A4 comprising Diamond Floral Magnifica Fragrance Example 4b, and PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) substantially non-odorous fragrance modulator as compared to Composition C4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 11 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition A4 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) substantially non-odorous fragrance modulator as compared to Composition C4, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 12 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition D4 comprising Diamond Floral Magnifica Fragrance Example 4b, and Caprylyl/Capryl Glucoside (i.e., Plantacare® 810 UP) substantially non-odorous fragrance modulator as compared to Composition F4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 13 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition G4 comprising Diamond Floral Magnifica Fragrance Example 4b, and Undecyl Glucoside (i.e., Simulsol® SL 11W) substantially non-odorous fragrance modulator as compared to Composition 14, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 14 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition J4 comprising Diamond Floral Magnifica Fragrance Example 4b, and Isocetyl Alcohol (i.e., Ceraphyl® ICA) substantially non-odorous fragrance modulator as compared to Composition L4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 15 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition A2 comprising Diamond Floral Magnifica Fragrance Example 4b, and Diisobutyl Adipate substantially non-odorous fragrance modulator as compared to Composition C2, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 16 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition A2 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and Diisobutyl Adipate substantially non-odorous fragrance modulator as compared to Composition C2, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 17 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition J2 comprising Diamond Floral Magnifica Fragrance Example 4b, and PPG-11 Stearyl Ether substantially non-odorous fragrance modulator as compared to Composition L2, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 18 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition J2 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-11 Stearyl Ether substantially non-odorous fragrance modulator as compared to Composition L2, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.
FIG. 19 provides the evaporation profile results for a representative component (i.e., indole) of test composition (MOD1) comprising a volatile fragrance mixture and PPG-3 Myristyl Ether (i.e., Tegosoft® APM) substantially non-odorous fragrance modulator as compared to a control composition (REF), and as a function of time elapsed since application of the composition.
FIG. 20 provides the evaporation profile results for a representative component (i.e., indole) of test composition (MOD2) comprising a volatile fragrance mixture and Neopentyl Glycol Diethylhexanoate (i.e., Scherecemol™ NGDO) substantially non-odorous fragrance modulator as compared to a control composition (REF), and as a function of time elapsed since application of the composition.
FIG. 21 provides the evaporation profile results for a representative component (i.e., indole) of test composition (MOD3) comprising a volatile fragrance material mixture and Kolliphor® EL substantially non-odorous fragrance modulator as compared to a control composition (REF), and as a function of time elapsed since application of the composition.
FIGS. 22( a )( i ) and 22( a ) ( ii ) provide the headspace chromatography of the fragrance profile of Composition L2, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.
FIGS. 22( b )( i ) and 22( b ) ( ii ) provide the headspace chromatography of the fragrance profile of Composition J2 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-11 Stearyl Ether substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.
FIGS. 23( a )( i ) and 23( a ) ( ii ) provide the headspace chromatography of the fragrance profile of Composition C4, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.
FIGS. 23( b )( i ) and 23( b ) ( ii ) provide the headspace chromatography of the fragrance profile of Composition A4 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-20 Methyl Glucose Ether (i.e., GLUCAM™ P-20) substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.
FIGS. 24( a )( i ) and 24( a ) ( ii ) provide the headspace chromatography of the fragrance profile of Composition L4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.
FIGS. 24( b )( i ) and 24( b ) ( ii ) provide the headspace chromatography of the fragrance profile of Composition J4 comprising Diamond Floral Magnifica Fragrance Example 4b, and Isocetyl Alcohol (i.e., Ceraphyl® ICA) substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.
FIGS. 25( a )( i ) and 25( a ) ( ii ) provides the headspace chromatography of the fragrance profile of Composition 14, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.
FIGS. 25( b )( i ) and 25( b ) ( ii ) provide the headspace chromatography of the fragrance profile of Composition G4 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and Undecyl Glucoside (i.e., Simulsol® SL 11W) substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.



DETAILED DESCRIPTION OF THE INVENTION
Definitions
As used herein, articles such as “a” and “an” when used in a claim, are understood to mean one or more of what is claimed or described.
As used herein, the terms “include”, “includes” and “including” are meant to be non-limiting.
As used herein, the term “body splash” means a body care formulation that is applied to the body. Typically, the body splash is applied to the body after bathing and provides a subtle hint of scent to the body. Body splashes are commonly used by consumers who prefer less strong fragrance compositions. A body splash may comprise an ethanol-free composition according to the present invention which comprises from 0.2-8 wt %, relative to the total weight of the composition, of a fragrance component. The body splash may further comprise alkyl polyglucosides as non-ionic surfactants.
As used herein, the term “body spray” means a formulation comprising fragrance materials intended to be applied to the body to prevent or mask body odor caused by the bacterial breakdown of perspiration on the body (e.g., armpits, feet, and other areas of the body). The body spray may also provide a fragrance expression to the consumers. Typically, body spray compositions are applied as an aerosol spray in an effective amount on the skin of a consumer.
As used herein, the term “composition” includes a fine fragrance composition intended for application to a body surface, such as for example, skin or hair, i.e., to impart a pleasant odor thereto, or cover a malodour thereof. They are generally in the form of perfume concentrates, perfumes, eau de parfums, eau de toilettes, aftershaves, or colognes. The fine fragrance compositions may be an ethanol-based composition. The term “composition” may also include a cosmetic composition, which comprises a fragrance material for the purposes of delivering a pleasant smell to drive consumer acceptance of the cosmetic composition. The term “composition” may also include body splashes or body sprays. The term “composition” may also include cleaning compositions, such as fabric care composition or home care compositions, including air care compositions (e.g., air freshners), for use on clothing or other substrates such as hard surfaces (e.g., dishes, floors, countertops). Additional non-limiting examples of “composition” may also include facial or body powder, deodorant, foundation, body/facial oil, mousse, creams (e.g., cold creams), waxes, sunscreens and blocks, bath and shower gels, lip balms, self-tanning compositions, masks and patches.
As used herein, the term “consumer” means both the user of the composition and the observer nearby or around the user.
As used herein, the term “diamond construction” means a fragrance formulation as shown in FIG. 1 b . In particular, the diamond construction relates to the relative weight % of the fragrance materials classified according to their vapor pressure category (i.e., low, moderate or high). A diamond constructed fragrance has a substantially greater amount of the perfume raw materials of a moderate volatility as comparied to the low and high volatile fragrance materials.
As used herein, the term “fragrance material” and “fragrance materials” relates to a perfume raw material (“PRM”), or a mixture of perfume raw materials (“PRMs”), that are used to impart an overall pleasant odour or fragrance profile to a composition. “Fragrance materials” can encompass any suitable perfume raw materials for fragrance uses, including materials such as, for example, alcohols, aldehydes, ketones, esters, ethers, acetates, nitriles, terpene hydrocarbons, nitrogenous or sulfurous heterocyclic compounds and essential oils. However, naturally occurring plant and animal oils and exudates comprising complex mixtures of various chemical components are also know for use as “fragrance materials”. The individual perfume raw materials which comprise a known natural oil can be found by reference to Journals commonly used by those skilled in the art such as “Perfume and Flavourist” or “Journal of Essential Oil Research”, or listed in reference texts such as the book by S. Arctander, Perfume and Flavor Chemicals, 1969, Montclair, N.J., USA and more recently re-publisehd by Allured Publishing Corporation Illinois (1994). Additionally, some perfume raw materials are supplied by the fragrance houses (Firmenich, International Flavors & Fragrances, Givaudan, Symrise) as mixtures in the form of proprietary speciality accords. Non-limiting examples of the fragrance materials useful herein include pro-fragrances such as acetal pro-fragrances, ketal pro-fragrances, ester pro-fragrances, hydrolyzable inorganic-organic pro-fragrances, and mixtures thereof. The fragrance materials may be released from the pro-fragrances in a number of ways. For example, the fragrance may be released as a result of simple hydrolysis, or by a shift in an equilibrium reaction, or by a pH-change, or by enzymatic release.
As used herein, the term “fragrance profile” means the description of how the fragrance is perceived by the human nose at any moment in time. The fragrance profile may change over time. It is a result of the combination of the low, moderate and high volatile fragrance materials, if present, of a fragrance. A fragrance profile is composed of 2 characteristics: ‘intensity’ and ‘character’. The ‘intensity’ relates to the perceived strength whilst ‘character’ refers to the odour impression or quality of the perfume, i.e., fruity, floral, woody, etc.
As used herein, the terms “modulator”, and “fragrance modulator” are used interchangeably to designate an agent having the capacity to affect the fragrance profile, such as for example, by impacting the fragrance materials' evaporation rate. The modulator may mediate its effect by lowering the vapor pressure of the fragrance materials and increasing their adherence to the substrate (skin and/or hair) thus ensuring a longer-lasting impression of the fragrance. By incorporating the modulator, it is desired that the fragrance profile, preferably the fragrance components of the diamond construction attributable to the moderate and high volatile fragrance materials of the composition can be perceived by a consumer, over a longer period of time, as compared to the same perception in the absence of the fragrance diamond construction and the modulator. Suitable examples of the modulator are provided herein below. However, as discovered by the inventors, simply adding modulators to a traditionally constructed fragrance composition (i.e., classical fragrance pyramid construction) will not ensure an improved or enhanced fidelity and/or longevity of the fragrance profile over time. Instead, it is only when the modulators are added in the presence of the fragrance diamond construction can the improved or enhanced fidelity and/or longevity of the fragrance profile, preferably attributable to the moderate and high volatile fragrance materials, be perceived as compared to control composition absent the fragrance diamond construction and modulators.
As used herein, the term “substantially non-odorous” means an agent that does not impart an odour of its own when added into a composition of the present invention. For example, a “substantially non-odorous fragrance modulator” does not impart a new odour that alters the character of the fragrance profile of the composition to which it is added. The term “substantially non-odorous” also encompasses an agent that may impart a minimal or slight odour of its own when added into a composition of the present invention. However, the odour imparted by the “substantially non-odorous fragrance modulator” is generally undetectable or tends to not substantively alter the character of the fragrance profile of the composition to which it is added initially or preferably over time. Furthermore, the term “substantially non-odorous” also includes materials that are perceivable only by a minority of people or those materials deemed “anosmic” to the majority of people. Furthermore, the term “substantially non-odorous” also includes materials that may, from particular suppliers, contain an odour due to impurities, such as when the materials contain the impurities at not more than about 5 wt %, preferably not more than 1 wt %, often even not more than 1 part per million (ppm). These impurities maybe removed by purification techniques known in the art as required to make them suitable for use in fragrance compositions of the present invention.
As used herein, the term “vapor pressure” means the partial pressure in air at a defined temperature (e.g., 25° C.) and standard atmospheric pressure (760 mmHg) for a given chemical species. It defines a chemical species' desire to be in the gas phase rather than the liquid or solid state. The higher the vapor pressure the greater the proportion of the material that will, at equilibrium, be found in a closed headspace. It is also related to the rate of evaporation of a fragrance material which is defined in an open environment where material is leaving the system. The vapor pressure is determined according to the reference program Advanced Chemistry Development (ACD/Labs) Software Version 14.02, or preferably the latest version update).
It is understood that the test methods that are disclosed in the Test Methods Section of the present application must be used to determine the respective values of the parameters of Applicants' inventions as described and claimed herein.
In all embodiments of the present invention, all percentages are by weight of the total composition, as evident by the context, unless specifically stated otherwise. All ratios are weight ratios, unless specifically stated otherwise, and all measurements are made at 25° C., unless otherwise designated.
Compositions
The inventors have surprisingly discovered a revolutionary new way of objectively classifying fragrance materials and then formulating those fragrance materials into complex fragrance mixtures having improved fragrance profile fidelity and longevity. Essentially, the solution is to formulate the fragrance materials into a diamond construction in the presence of a substantially non-odorous fragrance modulator to provide for improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters derived from the more volatile fragrance materials (i.e., moderate and high vapor pressure range of the perfumer's palette). In fact, the inventors have discovered that in the complete absence of the low volatile fragrance materials or at very low levels of the low volatilie fragrance materials (less than 10 wt % relative to the total weight of the fragrance component) there is insufficient character complexity and roundness of the fragrance profile for consumer acceptance of the composition. Therefore the level of low volatile fragrance materials needs to be carefully chosen between 10 wt % and 30 wt %, relative to the total weight of the fragrance component, to balance consumer acceptance and the desired improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters attributable to the moderate and/or high volatile fragrance materials.
Unlike previous proposed classification of fragrance materials according to their characteristic characters, which tends to be subjective, the inventors have established new rules to objectively classifying fragrance materials into low, moderate or high volatile fragrance materials according to their volatility using their vapor pressures defined at a suitable temperature. For example, methyl dihydrojasmonate which has been typically classified as a heart note under the traditional approach is now classified as a low volatile fragrance material because it has a vapor pressure of 0.00071000 Torr (0.000095 kPa) at 25° C. This new classification better reflects methyl dihydrojasmonate's technical properties of slow evaporation and long lasting.
Also unlike previous proposed uses of modulators to enhance fragrance profile, the inventors have established that the improved aforementioned advantages are not tied to a particular modulator of specific nature/structure but can be reapplied broadly. In fact, what the inventors have established is a systematic approach for providing longer lasting fragrance profiles that is totally unexpected and advantageous contribution to the perfumery technology.
Specifically, in one aspect, the present invention provides for a composition comprising a fragrance component present in an amount of from about 0.04 wt % to 30 wt %, preferably 1 wt % to about 30 wt %, more preferably less than about 25 wt %, yet more preferably less than about 20 wt %, yet even more preferably less than about 15 wt %, yet even more preferably less than about 10 wt % or most preferably less than about 8 wt %, relative to the total weight of the composition. Alternatively, the fragrance component is present in an amount of from about 0.04 wt %, 0.3 wt %, 1 wt %, 8 wt % or 10 wt %, to about 15 wt %, 20 wt %, 25 wt % or 30 wt %, relative to the total weight of the composition.
(i) Low Volatile Fragrance Materials
The fragrance component comprises at least one low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C. Preferably the composition according to the present invention comprises at least 3 low volatile fragrance materials, or at least 5 low volatile fragrance materials, or at least 7 low volatile fragrance materials. It is preferred that the composition of the present invention comprises low, preferably very low levels of the low volatile fragrance materials, lower than would traditionally be present in a fragrance pyramid three-tiered structure. As such, compositions of the present invention can comprise low levels of the low volatile fragrance material present in an amount of from about 10 wt % to about 30 wt %, preferably less than about 30 wt %, or preferably less than about 29 wt %, or preferably less than about 28 wt %, or preferably less than about 27 wt %, or preferably less than about 26 wt %, or preferably less than about 25 wt %, relative to the total weight of the fragrance component. Alternatively, the low volatile fragrance material is present in an amount of from about 10 wt %, 12 wt %, 15 wt %, 20 wt %, 25 wt % or 30 wt %, relative to the total weight of the fragrance component. If there is more than one low volatile fragrance materials, then the ranges provided hereinabove cover the total of all of the low volatile fragrance materials. Preferable examples of low volatile fragrances materials are provided in Table 1 below.
(ii) Moderate Volatile Fragrance Materials
The fragrance component comprises at least one moderate volatile fragrance material having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C. Preferably the composition according to the present invention comprises at least 3 moderate volatile fragrance materials, or at least 5 moderate volatile fragrance materials, or at least 7 moderate volatile fragrance materials. It is preferred that the composition of the present invention comprises high, preferably higher levels of the moderate volatile fragrance materials than would traditionally be present in a fragrance pyramid three-tiered structure. As such, compositions of the present invention can comprise high levels of the moderate volatile fragrance materials present in an amount of from about 40 wt % to about 80 wt %, preferably at least about 45 wt %, or preferably at least about 50 wt %, or preferably at least about 55 wt %, or preferably at least about 60 wt %, or preferably at least about 65 wt %, relative to the total weight of the fragrance component. Alternatively, the moderate volatile fragrance material is present in an amount less than about 75 wt %, or preferably less than 72 wt %, or preferably less than 70 wt %, relative to the total weight of the fragrance component. If there is more than one moderate volatile fragrance materials, then the ranges provided hereinabove cover the total of all of the moderate volatile fragrance materials. Preferable examples of moderate volatile fragrances materials are provided in Table 2 below.
(iii) High Volatile Fragrance Materials
The fragrance component comprises at least one high volatile fragrance material having a vapor pressure greater than 0.1 Torr (0.0133 kPa) at 25° C. Preferably the composition according to the present invention comprises at least 3 high volatile fragrance materials, or at least 5 high volatile fragrance materials, or at least 7 high volatile fragrance materials. It is preferred that the composition of the present invention comprises high volatile fragrance materials present in an amount of from about 1 wt % to about 30 wt %, preferably less than about 25 wt %, or preferably less than about 22 wt %, or preferably less than about 20 wt %, relative to the total weight of the fragrance component. Alternatively, the low volatile fragrance material is present in an amount of from about 6 wt %, 8 wt %, 10 wt %, 12 wt %, 14 wt % or 16 wt % relative to the total weight of the fragrance component. If there is more than one high volatile fragrance materials, then the ranges provided hereinabove cover the total of all of the high volatile fragrance materials. Preferable examples of high volatile fragrances materials are provided in Table 3 below.
(iv) Fragrance Modulators
The composition further comprises at least one substantially non-odorous fragrance modulator as described herein below. Preferable examples of the substantially non-odorous fragrance modulators are provided in Table 4 below.
Preferably, the substantially non-odorous fragrance modulator is present in an amount of from about 0.1 wt % to about 20 wt %, preferably from about 0.5 wt % to about 18 wt % or more preferably from about 2.5 wt % to about 15 wt % or combinations thereof, relative to the total weight of the composition. Alternatively, the substantially non-odorous fragrance modulator is present in an amount of from about 0.1 wt %, 0.5 wt % or 2.5 wt % to about 15 wt %, 18 wt % or 20 wt %, relative to the total weight of the composition. If there is more than one substantially non-odorous fragrance modulators, then the ranges provided hereinabove cover the total of all of the substantially non-odorous fragrance modulators.
The substantially non-odorous fragrance modulator of the present invention may be a liquid at temperatures lower than 100° C., preferably at ambient temperature. The substantially non-odorous fragrance modulators may be fully miscible with the fragrance materials to form a single phase liquid. However, if the fragrance materials are not entirely miscible, or are immiscible, then co-solvents (e.g., dipropylene glycol (DPG), triethyl citrate, or others as well known to those skilled in the art) can be added to aid in the solubility of the fragrance materials.
Preferably, the composition according to the present invention, wherein the substantially non-odorous fragrance modulator does not comprise: (i) isocetyl alcohol, PPG-3 myristyl ether, neopentyl glycol diethylhexanoate or their mixtures; and (ii) n-hexadecyl n-nonanoate, n-octadecyl n-nonanoate or their mixtures.
Preferably, the composition according to the present invention, wherein the substantially non-odorous fragrance modulator and fragrance component are present in a weight ratio from about 3:1 to about 1:3.
The inventors have surprisingly discovered that by formulating the fragrance component into a diamond construction in a composition, the effect of the substantially non-odorous fragrance modulator on the fragrance profile, particularly the characters of the fragrance profile which is attributable to the moderate and high volatile fragrance materials, preferably the moderate volatile fragrace materials, can be improved. By “improved” it is meant that the fragrance profile of the composition, particular the components contributed by the moderate and high volatile fragrance materials, can be perceived by the consumer at later time points such as, for example, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 10 hours, and possibly all the way up to 24 hrs after application as compared to controls, i.e., compositions containing the classical fragrance pyramid three-tiered structure and the substantially non-odorous fragrance modulator or compositions containing the classical fragrance pyramid three-tiered structure and no substantially non-odorous fragrance modulator.
Alternatively, by “improved” it can mean that the perception, by the consumer, of the fidelity of the fragrance profile contributed by the moderate and high volatile fragrance materials is markedly increased or enhanced as compared to the controls. “Increased” or “enhanced” means that the consumer perceives the fragrance profile, preferably the characters attributable to the moderate and/or high volatile fragrance materials, of a composition as not changing from its initial impression or the changes are minimal from when the composition was first applied to when it dissipates. In other words, the fidelity of the perceived fragrance profile of the composition is maintained over time.
Typically, it has been very difficult to formulate fragrance profile, particularly a floral or spicy character of the moderate volatile fragrance materials, which can last for very long periods, especially throughout the life of the composition after its application, without giving way to the stronger characters of the low volatile fragrance materials. The present invention of the diamond construction of fragrance materials with the substantially non-odorous fragrance modulators allows perfumers to increase the olfactive perception of the moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, to create new characters and address a re-occurring consumer issue that particular fragrance profiles, particularly those having floral or aromatic and spicy characters, do not last long enough.
Such a solution as presented herein provides enhanced or improved fidelity and/or longevity of the fragrance profile, particularly amongst those composition formulated from volatile fragrance materials having moderate to high vapor pressure ranges (greater than or equal to 0.001 Torr (0.000133 kPa) at 25° C.), without having to rely on the presence or significant amounts of the low volatile fragrance materials, which has a tendency to overpower and alter the overall fragrance profile, particularly over time. As a result, the present invention provides the perfumer options to formulate compositions having new fragrance profiles not possible before.
Volatile Solvents
The present invention provides the solution to the problem of extending the longevity of the fragrance profile of compositions, particularly fine fragrance and cosmetic compositions, preferably fine fragrance compositions, which commonly contain high levels of a volatile solvent. Preferably, the composition according to the present invention, further comprising a volatile solvent present in the amount of from about 50 wt % to about 80 wt %, or preferably from about 55 wt % to about 75 wt %, relative to the total weight of the composition, and wherein the solvent is a branch or unbranched C 1 to C 10 alkyl, akenyl or alkynyl group having at least one alcohol moiety, preferably ethanol, or isopropanol, or other alcohols (e.g., methanol, propanol, isopropanol, butanol, and mixtures thereof) commonly found in commercial fine fragrance products.
Accordingly, ethanol may be present in any of the compositions of the present invention, and more specifically, it will form from about 10 wt % to about 80 wt %, or even from about 25 wt % to about 75 wt % of the composition, or combinations thereof, relative to the total weight of the composition. Alternatively, ethanol may be present in an amount of from about 10 wt % or 25 wt % to about 75 wt % or 80 wt %, relative to the total weight of the composition. The ethanol useful in the present invention may be any acceptable quality of ethanol, compatible and safe for the specific intended use of the composition such as, for example, topical applications of fine fragrance or cosmetic compositions.
Water
In yet another aspect, water may be present in any of the compositions of the present invention, and more specifically, it shall not exceed about 40 wt %, preferably about 20 wt % or less, or more preferably about 10 wt % or less, relative to the total weight of the composition. Alternatively, water may be present in an amount of from about 10 wt % or about 20 wt % to about 40 wt %, relative to the total weight of the composition. When the composition is a cosmetic composition the level of water should not be so high that the product becomes cloudy thus negatively impacting the product aesthetics. It is understood that the amount of water present in the composition may be from the water present in the volatile solvent (e.g., ethanol) used in the composition, as the case may be.
Non-Volatile Solvents
The composition may comprise a non-volatile solvent or a mixture of non-volatile solvents. Non-limiting examples of non-volatile solvents include benzyl benzoate, diethyl phthalate, isopropyl myristate, propylene glycol, dipropylene glycol, triethyl citrate, and mixtures thereof. These solvents often are introduced to the product via the perfume oil as many perfume raw materials may be purchased as a dilution in one of these solvents. Where non-volatile solvents are present, introduced either with the perfume materials or separately, then for the purposes of calculating the proportion of fragrance component having a vapor pressure of less than 0.001 Torr (0.000133 kPa) at 25° C. the total fragrance components does not include non-volatile solvents. Where non-volatile solvents are present, introduced either with the perfume materials or separately, then for the purposes of calculating the total level of fragrance component this does not include non-volatile solvents. In addition if present with cyclic oligosacchrides, the non-volatile solvent may be included at a weight ratio of the non-volatile solvent to the cyclic oligosaccharide of less than 1:1, less than 1:2, less than 1:10, or less than 1:100.
Entrapment Materials
In yet another aspect, compositions of the present invention may comprise an entrapment material at a level such that the weight ratio of the entrapment material to the fragrance materials is in the range of from about 1:20 to about 20:1. Preferably, the composition may comprise an entrapment material present in the amount of from about 0.001 wt % to about 40 wt %, from about 0.1 wt % to about 25 wt %, from about 0.3 wt % to about 20 wt %, from about 0.5 wt % to about 10 wt %, or from about 0.75 wt % to about 5 wt %, relative to the total weight of the composition. The compositions disclosed herein may comprise from 0.001 wt % to 40%, from 0.1 wt % to 25 wt %, from 0.3 wt % to 20 wt %, from 0.5 wt % to 10 wt % or from 0.75 wt % to 5 wt %, relative to the total weight of the composition, of a cyclic oligosaccharide.
Suitable entrapment materials for use herein are selected from polymers; capsules, microcapsules and nanocapsules; liposomes, absorbents; cyclic oligosaccharides and mixtures thereof. Preferred are absorbents and cyclic oligosaccharides and mixtures thereof. Highly preferred are cyclic oligosaccharides (see PCT Publication Nos. WO2000/67721 (Procter & Gamble); and WO2000/67720 (Procter & Gamble); and U.S. Pat. No. 6,893,647 (Procter & Gamble)).
As used herein, the term “cyclic oligosaccharide” means a cyclic structure comprising six or more saccharide units. Preferred for use herein are cyclic oligosaccharides having six, seven or eight saccharide units and mixtures thereof, more preferably six or seven saccharide units and even more preferably seven saccharide units. It is common in the art to abbreviate six, seven and eight membered cyclic oligosaccharides to a, 1 and y respectively.
The cyclic oligosaccharide of the compositions used for the present invention may comprise any suitable saccharide or mixtures of saccharides. Examples of suitable saccharides include, but are not limited to, glucose, fructose, mannose, galactose, maltose and mixtures thereof. However, preferred for use herein are cyclic oligosaccharides of glucose. The preferred cyclic oligosaccharides for use herein are α-cyclodextrins or β-cyclodextrins, or mixtures thereof, and the most preferred cyclic oligosaccharides for use herein are β-cyclodextrins.
The cyclic oligosaccharide, or mixture of cyclic oligosaccharides, for use herein may be substituted by any suitable substituent or mixture of substituents. Herein the use of the term “mixture of substituents” means that two or more different suitable substituents can be substituted onto one cyclic oligosaccharide. The derivatives of cyclodextrins consist mainly of molecules wherein some of the OH groups have been substituted. Suitable substituents include, but are not limited to, alkyl groups; hydroxyalkyl groups; dihydroxyalkyl groups; (hydroxyalkyl)alkylenyl bridging groups such as cyclodextrin glycerol ethers; aryl groups; maltosyl groups; allyl groups; benzyl groups; alkanoyl groups; cationic cyclodextrins such as those containing 2-hydroxy-3-(dimethylamino) propyl ether; quaternary ammonium groups; anionic cyclodextrins such as carboxyalkyl groups, sulphobutylether groups, sulphate groups, and succinylates; amphoteric cyclodextrins; and mixtures thereof.
The substituents may be saturated or unsaturated, straight or branched chain. Preferred substituents include saturated and straight chain alkyl groups, hydroxyalkyl groups and mixtures thereof. Preferred alkyl and hydroxyalkyl substituents are selected from C 1 -C 8 alkyl or hydroxyalkyl groups or mixtures thereof, more preferred alkyl and hydroxyalkyl substituents are selected from C 1 -C 6 alkyl or hydroxyalkyl groups or mixtures thereof, even more preferred alkyl and hydroxyalkyl substituents are selected from C 1 -C 4 alkyl or hydroxyalkyl groups and mixtures thereof. Especially preferred alkyl and hydroxyalkyl substituents are propyl, ethyl and methyl, more especially hydroxypropyl and methyl and even more preferably methyl.
Preferred cyclic oligosaccharides for use in the present invention are unsubstituted, or are substituted by only saturated straight chain alkyl, or hydroxyalkyl substituents. Therefore, preferred examples of cyclic oligosaccharides for use herein are α-cyclodextrin, β-cyclodextrin, methyl-α-cyclodextrin, methyl-β-cyclodextrin, hydroxypropyl-α-cyclodextrin and hydroxypropyl-β-cyclodextrin. Most preferred examples of cyclic oligosaccharides for use herein are methyl-α-cyclodextrin and methyl-β-cyclodextrin. These are available from Wacker-Chemie GmbH Hanns-Seidel-Platz 4, Munchen, DE under the tradename Alpha W6 M and Beta W7 M respectively. Especially preferred is methyl-β-cyclodextrin.
The cyclic oligosaccharides of the compositions used for the present invention are preferably soluble in water, ethanol, or both water and ethanol. As used herein “soluble” means at least about 0.1 g of solute dissolves in 100 mL of solvent, at 25° C. and 1 standard atmospheric pressure (760 mmHg). Preferably the cyclic oligosaccharides for use herein have a solubility of at least about 1 g/100 mL, at 25° C. and 1 atm of pressure. Preferred is that cyclic oligosaccharides are only present at levels up to their solubility limits in a given composition at room temperature. A person skilled in the art will recognise that the levels of cyclic oligosaccharides used in the present invention will also be dependent on the components of the composition and their levels, for example the solvents used or the exact fragrance oils, or combination of fragrance oils, present in the composition. Therefore, although the limits stated for the entrapment material are preferred, they are not exhaustive.
Propellants
The compositions described herein may include a propellant. Some examples of propellants include compressed air, nitrogen, inert gases, carbon dioxide, and mixtures thereof. Propellants may also include gaseous hydrocarbons like propane, n-butane, isobutene, cyclopropane, and mixtures thereof. Halogenated hydrocarbons like 1,1-difluoroethane may also be used as propellants. Some non-limiting examples of propellants include 1,1,1,2,2-pentafluoroethane, 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, trans-1,3,3,3-tetrafluoroprop-1-ene, dimethyl ether, dichlorodifluoromethane (propellant 12), 1,1-dichloro-1,1,2,2-tetrafluoroethane (propellant 114), 1-chloro-1,1-difluoro-2,2-trifluoroethane (propellant 115), 1-chloro-1,1-difluoroethylene (propellant 142B), 1,1-difluoroethane (propellant 152A), monochlorodifluoromethane, and mixtures thereof. Some other propellants suitable for use include, but are not limited to, A-46 (a mixture of isobutane, butane and propane), A-31 (isobutane), A-17 (n-butane), A-108 (propane), AP70 (a mixture of propane, isobutane and n-butane), AP40 (a mixture of propane, isobutene and n-butane), AP30 (a mixture of propane, isobutane and n-butane), and 152A (1,1 diflouroethane). The propellant may have a concentration from about 15%, 25%, 30%, 32%, 34%, 35%, 36%, 38%, 40%, or 42% to about 70%, 65%, 60%, 54%, 52%, 50%, 48%, 46%, 44%, or 42% by weight of the total fill of materials stored within the container.
Antiperspirant Active
The compositions described herein may be free of, substantially free of, or may include an antiperspirant active (i.e., any substance, mixture, or other material having antiperspirant activity). Examples of antiperspirant actives include astringent metallic salts, like the inorganic and organic salts of aluminum, zirconium and zinc, as well as mixtures thereof. Such antiperspirant actives include, for example, the aluminum and zirconium salts, such as aluminum halides, aluminum hydroxyhalides, zirconyl oxyhalides, zirconyl hydroxyhalides, and mixtures thereof.
Other Ingredients
In yet another aspect, the composition consists essentially of the recited ingredients but may contain small amounts (not more than about 10 wt %, preferably no more than 5 wt %, or preferably no more than 2 wt % thereof, relative to the total weight of the composition) of other ingredients that do not impact on the fragrance profile, particularly the evaporation rate and release of the fragrance materials. For example, a fine fragrance composition may comprise stabilizing or anti-oxidant agents, UV filters or quenchers, or colouring agents, commonly used in perfumery. There are a number of other examples of additional ingredients that are suitable for inclusion in the present compositions, particularly in compositions for cosmetic use. These include, but are not limited to, alcohol denaturants such as denatonium benzoate; UV stabilisers such as benzophenone-2; antioxidants such as tocopheryl acetate; preservatives such as phenoxyethanol, benzyl alcohol, methyl paraben, and propyl paraben; dyes; pH adjusting agents such as lactic acid, citric acid, sodium citrate, succinic acid, phosphoric acid, sodium hydroxide, and sodium carbonate; deodorants and anti-microbials such as famesol and zinc phenolsulphonate; humectants such as glycerine; oils; skin conditioning agents such as allantoin; cooling agents such as trimethyl isopropyl butanamide and menthol; silicones; solvents such as hexylene glycol; hair-hold polymers such as those described in PCT Publication No. WO94/08557 (Procter & Gamble); salts in general, such as potassium acetate and sodium chloride and mixtures thereof.
In yet another aspect, the composition of the present invention, depending on its intended use, is a mixture of fragrance materials possibly together with other ingredients such as, for example, perfume carriers. By the term “perfume carrier”, it is meant to include materials which are practically neutral from a perfumery point of view, i.e., which does not significantly alter the organoleptic properties of perfuming components. The perfume carrier may be a compatible liquid or solid fillers, diluents, and the like. The term “compatible”, as used herein, means that the components of the compositions of this invention are capable of being combined with the primary actives of the present invention, and with each other, in a manner such that there is no interaction which would substantially reduce the efficacy of the composition under ordinary use situations. The type of carrier utilized in the present invention depends on the type of product desired and may comprise, but are not limited to, solutions, aerosols, emulsions (including oil-in-water or water-in-oil), gels, and liposomes. Preferably, the carrier is a liquid and will be a solvent such as, for example, dipropyleneglycol, diethyl phthalate, isopropyl myristate, benzyl benzoate, 2-(2-ethoxyethoxy)-1-ethanol, or ethyl citrate (triethyl citrate).
In yet another aspect, the compositions for use in the present invention may take any form suitable for use, more preferably for perfumery or cosmetic use. These include, but are not limited to, vapor sprays, aerosols, emulsions, lotions, liquids, creams, gels, sticks, ointments, pastes, mousses, powders, granular products, substrates, cosmetics (e.g., semi-solid or liquid makeup, including foundations) and the like. Preferably the compositions for use in the present invention take the form of a vapor spray. Compositions of the present invention can be further added as an ingredient to other compositions, preferably fine fragrance or cosmetic compositions, in which they are compatible. As such they can be used within solid composition or applied substrates etc.
Preferably, the compositions of the present invention comprise:
(i) a fragrance component present in an amount of from about 0.04 wt % to about 30 wt %, relative to the total weight of the composition, and wherein the fragrance component comprises:
(a) at least one low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C.; (b) at least one moderate volatile fragrance material having a vapor pressure from greater than or equal to 0.001 Torr to 0.1 Torr (0.000133 kPa to 0.0133 kPa) at 25° C.; and (c) at least one high volatile fragrance material having a vapor pressure greater than 0.1 Torr (0.0133 kPa) at 25° C.;
wherein the weight ratio of (a) versus the combination of (b) and (c) are present in the range of from about 1:2.33 to about 1:9;

(ii) at least one substantially non-odorous fragrance modulator present in the amount of from about 0.1 wt % to about 20 wt %, relative to the total weight of the composition; (iii) a volatile solvent present in an amount of from about 50 wt % to about 80 wt %, relative to the total weight of the composition; and (iv) optionally water.

Preferably, the present invention relates to a fine fragrance composition, preferably in the form of a perfume concentrate, a perfume, a parfum, an eau de toilette, an eau de parfum, or a cologne.
Preferably, the present invention relates to a composition, wherein the composition is in the form of a body splash or a body spray.
Therefore, it goes without saying that the compositions of the present invention encompasses any composition comprising any of the ingredients cited herein, in any embodiment wherein each such ingredient is independently present in any appropriate amount as defined herein. Many such compositions, than what is specifically set out herein, can be encompassed.
Article of Manufacture
The composition may be included in an article of manufacture comprising a spray dispenser. The spray dispenser may comprise a vessel for containing the composition to be dispensed. The spray dispenser may comprise an aerosolized composition (i.e., a composition comprising a propellant) within the vessel as well. Other non-limiting examples of spray dispensers include non-aerosol dispensers (e.g., vapor sprays), manually activated dispensers, pump-spray dispensers, or any other suitable spray dispenser available in the art.
Methods of Using the Compositions
The composition of the present invention according to any embodiments described herein is a useful perfuming composition, which can be advantageously used as consumer products intended to perfume any suitable substrate. As used herein, the term “substrate” means any surface to which the composition of the present invention may be applied to without causing any undue adverse effect. For example, this can include a wide range of surfaces including human or animal skin or hair, paper (fragranced paper), air in a room (air freshener or aromatherapy composition), fabric, furnishings, dishes, hard surfaces and related materials. Preferred substrates include body surfaces such as, for example, hair and skin, most preferably skin.
The composition of the present invention may be used in a conventional manner for fragrancing a substrate. An effective amount of the composition, typically from about 1 μL to about 10,000 μL, preferably from about 10 μL to about 1,000 μL, more preferably from about 25 μL to about 500 μL, or most preferably from about 50 μL to about 100 μL, or combinations thereof, is applied to the suitable substrate. Alternatively, an effective amount of the composition of the present invention is from about 1 μL, 10 μL, 25 μL or 50 μL to about 100 μL, 500 μL, 1,000 μL or 10,000 μL. The composition may be applied by hand or applied utilizing a delivery apparatus such as, for example, vaporizer or atomizer. Preferably, the composition is allowed to dry after its application to the substrate. The scope of the present invention should be considered to cover one or more distinct applications of the composition or the continuous release of a composition via a vaporizer or other type of atomizer.
The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein.
Non-limiting examples of floral character is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, a patchouli-type note and the like.
Non-limiting examples of of aromatic (or haerbaceous) and spicy character include: cinnamon, cloves, coriander, ginger, saffron, peppers of various kinds (e.g.: black pepper, pink pepper), caraway, cardamom, anise, tea, coffee, cumin, nutmeg, coumarin, basil, rosemary, thyme, mint, tarragon, marjoram, fennel, sage, juniper and the like.
Preferably, the fragrance profile or character of the composition of the present invention is detectable by a consumer at later time points such as, for example, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 10 hours, and possibly all the way up to 24 hours after application of the composition to a substrate as compared to controls (i.e., classical fragrance pyramid three-tiered structure).
The present invention also relates to compositions of the present invention that may be used as consumer products or articles selected from the group consisting of a fabric care product, an air care product, or a home care product. Therefore, according to this embodiment, the present invention provides a method of modifying or enhancing the odour properties of a substrate, preferably fabric, furnishings, dishes, hard surfaces and related materials, comprising contacting or treating the substrate with a composition of the present invention.
In another aspect, the present invention is also directed to a method of producing a consumer product comprising bringing into contact or mixing into the product an organoleptically active quantity of a composition of the present invention.
Fragrance Materials
In order that the compositions can be developed with the appropriate fragrance profile for the present invention, the “fragrance materials” have been classified as low, moderate or high volatile fragrance materials according to their volatility by their vapor pressure. This method of classifying fragrance materials by their vapor pressure avoids the problem of different classifications for the same fragrance material according to the traditional approach that relies on their subjective characteristic character. For the purpose of clarity, when the fragrance materials refer to a single individual compound, its vapor pressure should be determined according to the reference program cited above. In the case that the fragrance materials are a natural oil, extract or absolute, which comprises a mixture of several compounds, the vapor pressure of the complete oil should be treated a mixture of the individual perfume raw material components using the reference program cited above. The individual components and their level, in any given natural oil or extract, can be determined by direct injection of the oil into a GC-MS column for analysis as known by one skilled in the art. In the scenario that the fragrance materials are a proprietary specialty accord, so called ‘bases’, the vapor pressure, using the reference program cited above, should preferably be obtained from the supplier. However, it is understood by one skilled in the art that they can physically analyze the composition of a full fragrance oil available commercially to identity the fragrance raw materials and their levels using standard GC-MS techniques. This would be irrespective of whether they had been added to the fragrance oil as individual chemicals, as components of naturals or from proprietary bases. Although proprietary bases and naturals are included in our examples, when analyzing a commercially available fragrance via GC-MS one could simply identify the components of the base or natural oil as part of the overall fragrance mixture and their levels, without being able to identify which proprietary base or natural oil the fragrance had come from.
The nature and type of fragrance materials in the compositions according to the present invention can be selected by the skilled person, on the basis of its general knowledge together with the teachings contained herein, with reference to the intended use or application of the composition and the desired fragrance profile effect. Examples of suitable fragrance materials are disclosed in U.S. Pat. No. 4,145,184, U.S. Pat. No. 4,209,417, U.S. Pat. No. 4,515,705, and U.S. Pat. No. 4,152,272.
(i) Low Volatile Fragrance Materials
Preferable examples of fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C. are provided in Table 1 Low Volatile Fragrance Materials. Preferably, the low volatile fragrance material is selected from at least 1 material, or at least 2 materials, or at least 3 materials, or at least 5 materials, or at least 7 low volatile fragrance materials as disclosed in Table 1.





TABLE 1



Low Volatile Fragrance Materials








CAS


Vapor Pressure

No.
Number
IUPAC Name
Common Name**
(Torr at 25° C.)*









1.
1211-29-6
Cyclopentaneacetic acid, 3-oxo-2-
Methyl jasmonate
0.00096500



(2Z)-2-penten-1-yl-, methyl ester,



(1R,2R)-

2.
28219-
2-Buten-1-ol, 2-methyl-4-(2,2,3-
Hindinol
0.00096100


60-5
trimethyl-3-cyclopenten-1-yl)-

3.
93-08-3
Ethanone, 1-(2-naphthalenyl)-
Methyl beta-naphthyl
0.00095700




ketone

4.
67633-
3-Decanone, 1-hydroxy-
Methyl Lavender
0.00095100


95-8

Ketone

5.
198404-
Cyclopropanemethanol, 1-methyl-
Javanol ®
0.00090200


98-7
2-[(1,2,2-trimethylbicyclo[3.1.0]



hex-3-yl)methyl]-

6.
121-32-4
Benzaldehyde, 3-ethoxy-4-
Ethyl vanillin
0.00088400



hydroxy-

7.
72403-
3-Cyclohexene-1-methanol, 4-(4-
Myraldylacetate
0.00087900


67-9
methyl-3-penten-1-yl)-, 1-acetate

8.
28940-
2H-1,5-Benzodioxepin-3(4H)-one,
Oxalone ®
0.00083100


11-6
7-methyl-

9.
139504-
2-Butanol, 1-[[2-(1,1-
Amber core
0.00080300


68-0
dimethylethyl)cyclohexyl]oxy]-

10.
502847-
Spiro[5.5]undec-8-en-1-one, 2,2,7,
Spiro[5.5]undec-8-en-
0.00073100


01-0
9-tetramethyl-
1-one, 2,2,7,9-




tetramethyl-

11.
2570-03-8
Cyclopentaneacetic acid, 3-oxo-2-
trans-Hedione
0.00071000



pentyl-, methyl ester, (1R,2R)-rel-

12.
24851-
Cyclopentaneacetic acid, 3-oxo-2-
Methyl
0.00071000


98-7
pentyl-, methyl ester
dihydrojasmonate or




alternatives 1

13.
101-86-0
Octanal, 2-(phenylmethylene)-
Hexyl cinnamic
0.00069700




aldehyde

14.
365411-
Indeno[4,5-d]-1,3-dioxin, 4,4a,5,6,
Nebulone
0.00069200


50-3
7,8,9,9b-octahydro-7,7,8,9,9-



pentamethyl-

15.
37172-
Cyclopentanecarboxylic acid, 2-
Dihydro Iso Jasmonate
0.00067500


53-5
hexyl-3-oxo-, methyl ester

16.
65113-
3-Cyclopentene-1-butanol, α,β,2,2,
Sandalore ®
0.00062500


99-7
3-pentamethyl-

17.
68133-
Cyclopentanone, 2-(3,7-dimethyl-
Apritone
0.00062000


79-9
2,6-octadien-1-yl)-

18.
7212-44-4
1,6,10-Dodecatrien-3-ol, 3,7,11-
Nerolidol
0.00061600



trimethyl-

19.
53243-
2-Pentenenitrile, 3-methyl-5-
Citronitril
0.00061500


59-7
phenyl-, (2Z)-

20.
134123-
Benzenepropanenitrile, 4-ethyl-α,
Fleuranil
0.00057600


93-6
α-dimethyl-

21.
77-53-2
1H-3a,7-Methanoazulen-6-ol,
Cedrol Crude
0.00056900



octahydro-3,6,8,8-tetramethyl-,



(3R,3aS,6R,7R,8aS)-

22.
68155-
Ethanone, 1-(1,2,3,5,6,7,8,8a-
Iso Gamma Super
0.00056500


66-8
octahydro-2,3,8,8-tetramethyl-2-



naphthalenyl)-

23.
54464-
Ethanone, 1-(1,2,3,4,5,6,7,8-
Iso-E Super ®
0.00053800


57-2
octahydro-2,3,8,8-tetramethyl-2-



naphthalenyl)-

24.
774-55-0
Ethanone, 1-(5,6,7,8-tetrahydro-2-
Florantone
0.00053000



naphthalenyl)-

25.
141-92-4
2-Octanol, 8,8-dimethoxy-2,6-
Hydroxycitronellal
0.00052000



dimethyl-
Dimethyl Acetal

26.
20665-
Propanoic acid, 2-methyl-, 4-
Vanillin isobutyrate
0.00051200


85-4
formyl-2-methoxyphenyl ester

27.
79-78-7
1,6-Heptadien-3-one, 1-(2,6,6-
Hexalon
0.00049800



trimethyl-2-cyclohexen-1-yl)-

28.
6259-76-3
Benzoic acid, 2-hydroxy-, hexyl
Hexyl Salicylate
0.00049100



ester

29.
93-99-2
Benzoic acid, phenyl ester
Phenyl Benzoate
0.00047900

30.
153859-
Cyclohexanepropanol, 2,2,6-
Norlimbanol
0.00046900


23-5
trimethyl-α-propyl-, (1R,6S)-

31.
70788-
Cyclohexanepropanol, 2,2,6-
Timberol
0.00046900


30-6
trimethyl-α-propyl-

32.
68555-
Benzoic acid, 2-hydroxy-, 3-
Prenyl Salicylate
0.00045700


58-8
methyl-2-buten-1-yl ester

33.
950919-
2H-1,5-Benzodioxepin-3(4H)-one,
Cascalone
0.00045500


28-5
7-(1-methylethyl)-

34.
30168-
Butanal, 4-(octahydro-4,7-
Dupical
0.00044100


23-1
methano-5H-inden-5-ylidene)-

35.
1222-05-5
Cyclopenta[g]-2-benzopyran, 1,3,
Galaxolide ®
0.00041400



4,6,7,8-hexahydro-4,6,6,7,8,8-



hexamethyl-

36.
4602-84-0
2,6,10-Dodecatrien-1-ol, 3,7,11-
Farnesol
0.00037000



trimethyl-

37.
95962-
Cyclopentanone, 2-[2-(4-methyl-
Nectaryl
0.00036700


14-4
3-cyclohexen-1-yl)propyl]-

38.
4674-50-4
2(3H)-Naphthalenone, 4,4a,5,6,7,
Nootkatone
0.00035800



8-hexahydro-4,4a-dimethyl-6-(1-



methylethenyl)-, (4R,4aS,6R)-

39.
3487-99-8
2-Propenoic acid, 3-phenyl-,
Amyl Cinnamate
0.00035200



pentyl ester

40.
10522-
2-hydroxy-2-phenylethyl acetate
Styrolyl Acetate
0.00033900


41-5

41.
118-71-8
4H-Pyran-4-one, 3-hydroxy-2-
Maltol
0.00033700



methyl-

42.
128119-
1-Propanol, 2-methyl-3-[(1,7,7-
Bornafix
0.00033400


70-0
trimethylbicyclo[2.2.1]hept-2-yl)



oxy]-

43.
103614-
1-Naphthalenol, 1,2,3,4,4a,5,8,8a-
Octalynol
0.00033200


86-4
octahydro-2,2,6,8-tetramethyl-

44.
7785-33-3
2-Butenoic acid, 2-methyl-, (2E)-
Geranyl Tiglate
0.00033200



3,7-dimethyl-2,6-octadien-1-yl



ester, (2E)-

45.
117933-
1,3-Dioxane, 2-(2,4-dimethyl-3-
Karanal
0.00033100


89-8
cyclohexen-1-yl)-5-methyl-5-(1-



methylpropyl)-

46.
629-92-5
Nonadecane
Nonadecane
0.00032500

47.
67801-
4-Penten-2-ol, 3-methyl-5-(2,2,3-
Ebanol
0.00028100


20-1
trimethyl-3-cyclopenten-1-yl)-

48.
65416-
Propanoic acid, 2-methyl-, 2-
Maltol Isobutyrate
0.00028000


14-0
methyl-4-oxo-4H-pyran-3-yl ester

49.
28219-
2-Buten-1-ol, 2-ethyl-4-(2,2,3-
Laevo Trisandol
0.00028000


61-6
trimethyl-3-cyclopenten-1-yl)-

50.
5986-55-0
1,6-Methanonaphthalen-1(2H)-ol,
Healingwood
0.00027800



octahydro-4,8a,9,9-tetramethyl-,



(1R,4S,4aS,6R,8aS)-

51.
195251-
2H-1,5-Benzodioxepin-3(4H)-one,
Transluzone
0.00026500


91-3
7-(1,1-dimethylethyl)-

52.
3100-36-5
8-Cyclohexadecen-1-one
Cyclohexadecenone
0.00025300

53.
65405-
Benzoic acid, 2-hydroxy-, (3Z)-3-
cis-3-Hexenyl
0.00024600


77-8
hexen-1-yl ester
salicylate

54.
4940-11-8
4H-Pyran-4-one, 2-ethyl-3-
Ethyl Maltol
0.00022800



hydroxy-

55.
541-91-3
Cyclopentadecanone, 3-methyl-
Muskone
0.00017600

56.
118-58-1
Benzoic acid, 2-hydroxy-,
Benzyl salicylate
0.00017500



phenylmethyl ester

57.
81783-
6,8-Nonadien-3-one, 2,4,4,7-
Labienoxime
0.00017300


01-9
tetramethyl-, oxime

58.
25485-
Benzoic acid, 2-hydroxy-,
Cyclohexyl Salicylate
0.00017300


88-5
cyclohexyl ester

59.
91-87-2
Benzene, [2-(dimethoxymethyl)-1-
Amyl Cinnamic
0.00016300



hepten-1-yl]-
Aldehyde Dimethyl




Acetal

60.
104864-
3-Cyclopentene-1-butanol, β,2,2,
Firsantol
0.00016000


90-6
3-tetramethyl-δ-methylene-

61.
224031-
4-Penten-1-one, 1-spiro[4.5]dec-7-
Spirogalbanone
0.00015300


70-3
en-7-yl-

62.
134-28-1
5-Azulenemethanol,
Guaiyl Acetate
0.00013400



1,2,3,4,5,6,7,8-octahydro-α,α,3,8-



tetramethyl-, 5-acetate,



(3S,5R,8S)-

63.
236391-
Acetic acid, 2-(1-oxopropoxy)-, 1-
Romandolide ®
0.00012400


76-7
(3,3-dimethylcyclohexyl)ethyl



ester

64.
115-71-9
2-Penten-1-ol, 5-[(1R,3R,6S)-2,3-
cis-alpha-Santalol
0.00011800



dimethyltricyclo[2.2.1.02,6]hept-



3-yl]-2-methyl-, (2Z)-

65.
107898-
4-Penten-2-ol, 3,3-dimethyl-5-(2,
Polysantol ®
0.00011700


54-4
2,3-trimethyl-3-cyclopenten-1-yl)-

66.
69486-
5,8-Methano-2H-1-benzopyran-2-
Florex ®
0.00011000


14-2
one, 6-ethylideneoctahydro-

67.
84697-
Heptanal, 2-[(4-methylphenyl)
Acalea
0.00010100


09-6
methylene]-

68.
14595-
4-Cyclopentadecen-1-one, (4Z)-
Exaltenone
0.00009640


54-1

69.
32388-
Ethanone, 1-[(3R,3aR,7R,8aS)-2,3,
Vertofix ®
0.00008490


55-9
4,7,8,8a-hexahydro-3,6,8,8-



tetramethyl-1H-3a,7-



methanoazulen-5-yl]-

70.
131812-
1,3-Dioxolane, 2,4-dimethyl-2-(5,
Okoumal ®
0.00007600


67-4
6,7,8-tetrahydro-5,5,8,8-



tetramethyl-2-naphthalenyl)-

71.
106-02-5
Oxacyclohexadecan-2-one
Exaltolide ®
0.00006430

72.
141773-
1-Propanol, 2-[1-(3,3-
Helvetolide ®
0.00005790


73-1
dimethylcyclohexyl)ethoxy]-2-



methyl-, 1-propanoate

73.
63314-
5-Cyclopentadecen-1-one, 3-
Delta Muscenone
0.00005650


79-4
methyl-

74.
77-42-9
2-Penten-1-ol, 2-methyl-5-
cis-beta-Santalol
0.00004810



[(1S,2R,4R)-2-methyl-3-



methylenebicyclo[2.2.1]hept-2-



yl]-, (2Z)-

75.
362467-
2H-1,5-Benzodioxepin-3(4H)-one,
Azurone
0.00004770


67-2
7-(3-methylbutyl)-

76.
28371-
Ethanone, 1-(2,6,10-trimethyl-2,5,
Trimofix O
0.00004580


99-5
9-cyclododecatrien-1-yl)-

77.
16223-
1H-3a,6-Methanoazulene-3-
Khusimol
0.00004400


63-5
methanol, octahydro-7,7-dimethyl-



8-methylene-, (3S,3aR,6R,8aS)-

78.
10461-
Benzeneacetonitrile, α-
Peonile
0.00004290


98-0
cyclohexylidene-

79.
90-17-5
Benzenemethanol, α-
Rosacetol
0.00004240



(trichloromethyl)-, 1-acetate

80.
50607-
Benzoic acid, 2-[(2-
Mevantraal
0.00004070


64-2
methylpentylidene)amino]-,



methyl ester

81.
29895-
5-Hydroxy-2-benzyl-1,3-dioxane
Acetal CD
0.00004050


73-6

82.
94-47-3
Benzoic acid, 2-phenylethyl ester
Phenyl Ethyl Benzoate
0.00003480

83.
3100-36-5
Cyclohexadec-8-en-1-one
Globanone ®
0.00003310

84.
37609-
5-Cyclohexadecen-1-One
Ambretone
0.00003310


25-9

85.
66072-
Cyclohexanol, 4-(1,7,7-
Iso Bornyl
0.00003010


32-0
trimethylbicyclo[2.2.1]hept-2-yl)-
Cyclohexanol

86.
31906-
3-Cyclohexene-1-carboxaldehyde,
Lyral ®
0.00002940


04-4
4-(4-hydroxy-4-methylpentyl)-

87.
21145-
Ethanone, 1-(5,6,7,8-tetrahydro-
Musk Plus
0.00002860


77-7
3,5,5,6,8,8-hexamethyl-2-



naphthalenyl)-

88.
21145-
Ethanone, 1-(5,6,7,8-tetrahydro-3,
Fixolide
0.00002860


77-7
5,5,6,8,8-hexamethyl-2-



naphthalenyl)-

89.
22442-
2-Cyclopentadecen-1-one, 3-
Muscenone
0.00002770


01-9
methyl-

90.
109-29-5
Oxacycloheptadecan-2-one
Silvanone Ci
0.00002600

91.
101-94-0
Benzeneacetic acid, 4-
Para Cresyl Phenyl
0.00002330



methylphenyl ester
Acetate

92.
102-20-5
Benzeneacetic acid, 2-phenylethyl
Phenyl Ethyl Phenyl
0.00002300



ester
Acetate

93.
118562-
Cyclododecaneethanol, β-methyl-
Hydroxyambran
0.00001800


73-5

94.
103-41-3
2-Propenoic acid, 3-phenyl-,
Benzyl Cinnamate
0.00001050



phenylmethyl ester

95.
4707-47-5
Benzoic acid, 2,4-dihydroxy-3,6-
Veramoss
0.00001050



dimethyl-, methyl ester

96.
183551-
Naphtho[2,1-b]furan-6(7H)-one,
Myrrhone
0.00000977


83-9
8,9-dihydro-1,5,8-trimethyl-, (8R)-

97.
102-17-0
Benzeneacetic acid, (4-
Para Anisyl Phenyl
0.00000813



methoxyphenyl)methyl ester
Acetate

98.
120-11-6
Benzene, 2-methoxy-1-
Benzyl Iso Eugenol
0.00000676



(phenylmethoxy)-4-(1-propen-1-



yl)-

99.
102-22-7
Benzeneacetic acid, (2E)-3,7-
Geranyl Phenylacetate
0.00000645



dimethyl-2,6-octadien-1-yl ester

100.
111879-
Oxacyclohexadec-12-en-2-one,
Habanolide 100%
0.00000431


80-2
(12E)-

101.
87-22-9
Benzoic acid, 2-hydroxy-, 2-
Phenyl Ethyl
0.00000299



phenylethyl ester
Salicylate

102.
78-37-5
2-Propenoic acid, 3-phenyl-, 1-
Linalyl Cinnamate
0.00000174



ethenyl-1,5-dimethyl-4-hexen-1-yl



ester

103.
28645-
Oxacycloheptadec-10-en-2-one
Ambrettolide
0.00000139


51-4

104.
123-69-3
Oxacycloheptadec-8-en-2-one,
Ambrettolide
0.00000136



(8Z)-

105.
3391-83-1
1,7-Dioxacycloheptadecan-8-one
Musk RI
0.00000057

106.
68527-
7-Octen-2-ol, 8-(1H-indol-1-yl)-
Indolene
0.000000445


79-7
2,6-dimethyl-

107.
89-43-0
Methyl 2-[(7-hydroxy-3,7-
Aurantinol
0.0000000100



dimethyloctylidene)amino]benzoate

108.
54982-
1,4-Dioxacyclohexadecane-5,16-
Zenolide
0.00000000834


83-1
dione

109.
105-95-3
1,4-Dioxacycloheptadecane-5,17-
Ethylene Brassylate
0.00000000313



dione

110.
3681-73-0
Hexadecanoic acid, (2E)-3,7-
Hexarose
0.00000000300



dimethyl-2,6-octadien-1-yl ester

111.
4159-29-9
Phenol, 4-[3-(benzoyloxy)-1-
Coniferyl benzoate
0.00000000170



propen-1-yl]-2-methoxy-

112.
144761-
Benzoic acid, 2-[(1-hydroxy-3-
Trifone DIPG
0.00000000093


91-1
phenylbutyl)amino]-, methyl ester



1 Non-limiting examples of alternative qualities from various suppliers can be purchased under the following tradenames: Kharismal ® Super (IFF), Kharismal ® (IFF), Hedione ® (Firmenich), Hedione ® HC (Firmenich), Paradisone (Firmenich), Cepionate (Zenon), Super cepionate (Zenon), Claigeon ® (Zenon).

*Vapor Pressures are acquired as described in the Test Methods Section.

**Origin: The low volatile fragrance materials may be obtained from one or more of the following companies: Firmenich (Geneva, Switzerland), Symrise AG (Holzminden, Germany), Givaudan (Argenteuil, France), IFF (Hazlet, New Jersey), Bedoukian (Danbury, Connecticut), Sigma Aldrich (St. Louis, Missouri), Millennium Speciality Chemicals (Olympia Fields, Illinois), Polarone International (Jersey City, New Jersey), and Aroma & Flavor Specialities (Danbury, Connecticut).















































































































































































































































































Exemplary low volatile fragrance materials selected from the group of Table 1 Low Volatile Fragrance Materials are preferred. However, it is understood by one skilled in the art that other low volatile fragrance materials, not recited in Table 1, would also fall within the scope of the present invention, so long as they have a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C.
Preferably, the compositions of the present invention, wherein: (i)(a) the low volatile fragrance material is selected from the group of Table 1 Low Volatile Fragrance Materials 1, 4-6, 8, 12-16, 18, 22-25, 27-28, 31, 34-37, 41, 45, 47, 52-55, 57, 60, 61, 63, 65, 68, 69-74, 75, 78, 80, 83-84, 89, 94, 99, 102, 104, 106-108, and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 1-5, and mixtures thereof.
Preferably, the compositions of the present invention, wherein: (i)(a) the low volatile fragrance material is selected from the group consisting of Table 1 Low Volatile Fragrance Materials 1-6, 8-9, 12-14, 16, 18-19, 23, 25-28, 31, 34-35, 37, 41-42, 45, 47-49, 53-55, 57-60, 63, 65, 69, 71-73, 75, 78-79, 81, 84-85, 95, 100, 103, 105, 107, 109 and mixtures thereof, and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 6-8, and mixtures thereof.
Preferably, the compositions of the present invention, the low volatile fragrance material is selected from the group (as described herein above), and wherein this group of low volatile fragrance material has at least about 20 wt %, at least about 30 wt %, at least about 40 wt %, at least about 50 wt %, at least about 60 wt %, or at least about 70 wt %, relative to the total weight of the low volatile fragrance material.
(ii) Moderate Volatile Fragrance Materials
Preferable examples of moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C. are provided in Table 2 Moderate Volatile Fragrance Materials. Preferably, the moderate volatile fragrance material is selected from at least 1 material, or at least 2 materials, or at least 3 materials, or at least 5 materials, or at least 7 moderate volatile fragrance materials as disclosed in Table 2.





TABLE 2



Moderate Volatile Fragrance Materials








CAS


Vapor Pressure

No.
Number
IUPAC Name
Common Name**
(Torr at 25° C.)*









1.
24168-70-5
Pyrazine, 2-methoxy-3-(1-
Methoxyisobutylpyrazine
0.09950000



methylpropyl)-

2.
89-79-2
Cyclohexanol, 5-methyl-2-
Iso-Pulegol
0.09930000



(1-methylethenyl)-, (1R,



2S,5R)-

3.
112-12-9
2-Undecanone
Methyl Nonyl Ketone
0.09780000

4.
103-05-9
Benzenepropanol, α,α-
Phenyl Ethyl Dimethyl
0.09770000



dimethyl-
Carbinol

5.
125-12-2
Bicyclo[2.2.1]heptan-2-ol,
Iso Bornyl Acetate
0.09590000



1,7,7-trimethyl-, 2-acetate,



(1R,2R,4R)-rel-

6.
78-70-6
1,6-Octadien-3-ol, 3,7-
Linalool
0.09050000



dimethyl-

7.
101-97-3
Benzeneacetic acid, ethyl
Ethyl Phenyl Acetate
0.08970000



ester

8.
100-86-7
Benzeneethanol, α,α-
Dimethyl Benzyl Carbinol
0.08880000



dimethyl-

9.
188570-78-7
Cyclopropanecarboxylic
Montaverdi
0.08640000



acid, (3Z)-3-hexen-1-yl



ester

10.
67634-25-7
3-Cyclohexene-1-
Floralate
0.08500000



methanol, 3,5-dimethyl-,



1-acetate

11.
112-44-7
Undecanal
Undecyl Aldehyde
0.08320000

12.
32669-00-4
Ethanone, 1-(3-
Tanaisone ®
0.08150000



cycloocten-1-yl)-

13.
98-53-3
Cyclohexanone, 4-(1,1-
Patchi
0.07780000



dimethylethyl)-

14.
35854-86-5
6-Nonen-1-ol, (6Z)-
cis-6-None-1-ol
0.07770000

15.
5331-14-6
Benzene, (2-butoxyethyl)-
Butyl phenethyl ether
0.07760000

16.
80-57-9
Bicyclo[3.1.1]hept-3-en-2-
Verbenone
0.07730000



one, 4,6,6-trimethyl-

17.
22471-55-2
Cyclohexanecarboxylic
Thesaron
0.07670000



acid, 2,2,6-trimethyl-,



ethyl ester, (1R,6S)-rel-

18.
60-12-8
Benzeneethanol
Phenethyl alcohol
0.07410000

19.
106-26-3
2,6-Octadienal, 3,7-
Neral
0.07120000



dimethyl-, (2Z)-

20.
5392-40-5
2,6-Octadienal, 3,7-
Citral
0.07120000



dimethyl-

21.
89-48-5
Cyclohexanol, 5-methyl-2-
Menthyl Acetate
0.07070000



(1-methylethyl)-, 1-



acetate, (1R,2S,5R)-rel-

22.
119-36-8
Benzoic acid, 2-hydroxy-,
Methyl salicylate
0.07000000



methyl ester

23.
4180-23-8
Benzene, 1-methoxy-4-
Anethol
0.06870000



(1E)-1-propen-1-yl-

24.
7549-37-3
2,6-Octadiene, 1,1-
Citral Dimethyl Acetal
0.06780000



dimethoxy-3,7-dimethyl-

25.
25225-08-5
Cyclohexanemethanol, α,
Aphermate
0.06780000



3,3-trimethyl-, 1-formate

26.
3913-81-3
2-Decenal, (2E)-
2-Decene-1-al
0.06740000

27.
15373-31-6
3-Cyclopentene-1-
Cantryl ®
0.06700000



acetonitrile, 2,2,3-



trimethyl-

28.
6485-40-1
2-Cyclohexen-1-one, 2-
Laevo carvone
0.06560000



methyl-5-(1-



methylethenyl)-, (5R)-

29.
16587-71-6
Cyclohexanone, 4-(1,1-
Orivone
0.06490000



dimethylpropyl)-

30.
62406-73-9
6,10-
Opalal CI
0.06290000



Dioxaspiro[4.5]decane,



8,8-dimethyl-7-(1-



methylethyl)-

31.
3720-16-9
2-Cyclohexen-1-one, 3-
Livescone
0.06270000



methyl-5-propyl-

32.
13816-33-6
Benzonitrile, 4-(1-
Cumin Nitrile
0.06230000



methylethyl)-

33.
67019-89-0
2,6-Nonadienenitrile
Violet Nitrile
0.06200000

34.
53398-85-9
Butanoic acid, 2-methyl-,
cis-3-Hexenyl Alpha
0.06130000



(3Z)-3-hexen-1-yl ester
Methyl Butyrate

35.
208041-98-9
n/a
Jasmonitrile
0.05920000

36.
16510-27-3
Benzene, 1-
Toscanol
0.05870000



(cyclopropylmethyl)-4-



methoxy-

37.
111-80-8
2-Nonynoic acid, methyl
Methyl Octine Carbonate
0.05680000



ester

38.
103-45-7
Acetic acid, 2-phenylethyl
Phenyl Ethyl Acetate
0.05640000



ester

39.
2550-26-7
2-Butanone, 4-phenyl-
Benzyl Acetone
0.05570000

40.
13491-79-7
Cyclohexanol, 2-(1,1-
Verdol
0.05430000



dimethylethyl)-

41.
7786-44-9
2,6-Nonadien-1-ol
2,6-Nonadien-1-ol
0.05370000

42.
103-28-6
Propanoic acid, 2-methyl-,
Benzyl Iso Butyrate
0.05130000



phenylmethyl ester

43.
104-62-1
Formic acid, 2-phenylethyl
Phenyl Ethyl Formate
0.05050000



ester

44.
28462-85-3
Bicyclo[2.2.1]heptan-2-ol,
Humus Ether
0.04870000



1,2,3,3-tetramethyl-, (1R,



2R,4S)-rel-

45.
122-03-2
Benzaldehyde, 4-(1-
Cuminic Aldehyde
0.04820000



methylethyl)-

46.
358331-95-0
2,5-Octadien-4-one, 5,6,7-
Pomarose
0.04810000



trimethyl-, (2E)-

47.
562-74-3
3-Cyclohexen-1-ol, 4-
Terpinenol-4
0.04780000



methyl-1-(1-methylethyl)-

48.
68527-77-5
3-Cyclohexene-1-
Isocyclogeraniol
0.04640000



methanol, 2,4,6-trimethyl-

49.
35852-46-1
Pentanoic acid, (3Z)-3-
Cis-3-Hexenyl Valerate
0.04580000



hexen-1-yl ester

50.
2756-56-1
Bicyclo[2.2.1]heptan-2-ol,
Iso Bornyl Propionate
0.04540000



1,7,7-trimethyl-, 2-



propanoate, (1R,2R,4R)-



rel-

51.
14374-92-6
Benzene, 1-methyl-4-(1-
Verdoracine
0.04460000



methylethyl)-2-(1-propen-



1-yl)-

52.
6784-13-0
3-Cyclohexene-1-
Limonenal
0.04380000



propanal, β,4-dimethyl-

53.
8000-41-7
2-(4-methyl-1-cyclohex-3-
Alpha Terpineol
0.04320000



enyl)propan-2-ol

54.
41884-28-0
1-Hexanol, 5-methyl-2-(1-
Tetrahydro Lavandulol
0.04230000



methylethyl)-, (2R)-

55.
22457-23-4
3-Heptanone, 5-methyl-,
Stemone ®
0.04140000



oxime

56.
104-50-7
2(3H)-Furanone, 5-
Gamma Octalactone
0.04080000



butyldihydro-

57.
143-08-8
1-Nonanol
Nonyl Alcohol
0.04070000

58.
3613-30-7
Octanal, 7-methoxy-3,7-
Methoxycitronellal
0.04020000



dimethyl-

59.
67634-00-8
Acetic acid, 2-(3-
Allyl Amyl Glycolate
0.04000000



methylbutoxy)-, 2-propen-



1-yl ester

60.
464-45-9
Bicyclo[2.2.1]heptan-2-ol,
1-Borneol
0.03980000



1,7,7-trimethyl-, (1S,2R,



4S)-

61.
124-76-5
Bicyclo[2.2.1]heptan-2-ol,
1.7.7-Trimethyl-Bicyclo-
0.03980000



1,7,7-trimethyl-, (1R,2R,
1.2.2-Heptanol-2



4R)-rel-

62.
67874-72-0
Cyclohexanol, 2-(1,1-
Coniferan
0.03980000



dimethylpropyl)-, 1-



acetate

63.
80-26-2
3-Cyclohexene-1-
Terpinyl Acetate
0.03920000



methanol, α,α,4-trimethyl-,



1-acetate

64.
498-81-7
Cyclohexanemethanol, α,
Dihydro Terpineol
0.03920000



α,4-trimethyl-

65.
112-45-8
10-Undecenal
Undecylenic aldehyde
0.03900000

66.
35044-57-6
2,4-Cyclohexadiene-1-
Ethyl Safranate
0.03880000



carboxylic acid, 2,6,6-



trimethyl-, ethyl ester

67.
106-21-8
1-Octanol, 3,7-dimethyl-
Dimethyl Octanol
0.03860000

68.
84560-00-9
Cyclopentanol, 2-pentyl-
Cyclopentol
0.03790000

69.
82461-14-1
Furan, tetrahydro-2,4-
Rhubafuran ®
0.03780000



dimethyl-4-phenyl-

70.
56011-02-0
Benzene, [2-(3-
Phenyl Ethyl Isoamyl
0.03690000



methylbutoxy)ethyl]-
Ether

71.
103-37-7
Butanoic acid,
Benzyl Butyrate
0.03660000



phenylmethyl ester

72.
6378-65-0
Hexyl hexanoate
Hexyl hexanoate
0.03490000

73.
118-61-6
Benzoic acid, 2-hydroxy-,
Ethyl salicylate
0.03480000



ethyl ester

74.
98-52-2
Cyclohexanol, 4-(1,1-
Patchon
0.03480000



dimethylethyl)-

75.
115-99-1
1,6-Octadien-3-ol, 3,7-
Linalyl Formate
0.03440000



dimethyl-, 3-formate

76.
112-54-9
Dodecanal
Lauric Aldehyde
0.03440000

77.
53046-97-2
3,6-Nonadien-1-ol, (3Z,
3,6 Nonadien-1-ol
0.03360000



6Z)-

78.
76649-25-7
3,6-Nonadien-1-ol
3,6-Nonadien-1-ol
0.03360000

79.
141-25-3
3,7-Dimethyloct-6-en-1-ol
Rhodinol
0.03290000

80.
1975-78-6
Decanenitrile
Decanonitrile
0.03250000

81.
2216-51-5
Cyclohexanol, 5-methyl-2-
L-Menthol
0.03230000



(1-methylethyl)-, (1R,2S,



5R)-

82.
3658-77-3
4-hydroxy-2,5-
Pineapple Ketone
0.03200000



dimethylfuran-3-one

83.
103-93-5
Propanoic acid, 2-methyl-,
Para Cresyl iso-Butyrate
0.03120000



4-methylphenyl ester

84.
24717-86-0
Propanoic acid, 2-methyl-,
Abierate
0.03110000



(1R,2S,4R)-1,7,7-



trimethylbicyclo[2.2.1]



hept-2-yl ester, rel-

85.
67845-46-9
Acetaldehyde, 2-(4-
Aldehyde XI
0.03090000



methylphenoxy)-

86.
67883-79-8
2-Butenoic acid, 2-methyl-,
Cis-3-Hexenyl Tiglate
0.03060000



(3Z)-3-hexen-1-yl ester,



(2E)-

87.
33885-51-7
Bicyclo[3.1.1]hept-2-ene-
Pino Acetaldehyde
0.03040000



2-propanal, 6,6-dimethyl-

88.
105-85-1
6-Octen-1-ol, 3,7-
Citronellyl Formate
0.03000000



dimethyl-, 1-formate

89.
70214-77-6
2-Nonanol, 6,8-dimethyl-
Nonadyl
0.03010000

90.
215231-33-7
Cyclohexanol, 1-methyl-3-
Rossitol
0.02990000



(2-methylpropyl)-

91.
120-72-9
1H-Indole
Indole
0.02980000

92.
2463-77-6
2-Undecenal
2-Undecene-1-al
0.02970000

93.
675-09-2
2H-Pyran-2-one, 4,6-
Levistamel
0.02940000



dimethyl-

94.
98-55-5
3-Cyclohexene-1-
Alpha-Terpineol
0.02830000



methanol, α,α,4-trimethyl-

95.
81786-73-4
3-Hepten-2-one, 3,4,5,6,6-
Koavone
0.02750000



pentamethyl-, (3Z)-

96.
122-97-4
Benzenepropanol
Phenyl Propyl Alcohol
0.02710000

97.
39212-23-2
2(3H)-Furanone, 5-
Methyl Octalactone
0.02700000



butyldihydro-4-methyl-

98.
53767-93-4
7-Octen-2-ol, 2,6-
Dihydro Terpinyl Acetate
0.02690000



dimethyl-, 2-acetate

99.
35044-59-8
1,3-Cyclohexadiene-1-
Ethyl Safranate
0.02660000



carboxylic acid, 2,6,6-



trimethyl-, ethyl ester

100.
104-55-2
2-Propenal, 3-phenyl-
Cinnamic Aldehyde
0.02650000

101.
144-39-8
1,6-Octadien-3-ol, 3,7-
Linalyl Propionate
0.02630000



dimethyl-, 3-propanoate

102.
61931-80-4
1,6-Nonadien-3-ol, 3,7-
3,7-Dimethyl-1,6-
0.02630000



dimethyl-, 3-acetate
nonadien-3-yl acetate

103.
102-13-6
Benzeneacetic acid, 2-
Iso Butyl Phenylacetate
0.02630000



methylpropyl ester

104.
65443-14-3
Cyclopentanone, 2,2,5-
Veloutone
0.02610000



trimethyl-5-pentyl-

105.
141-12-8
2,6-Octadien-1-ol, 3,7-
Neryl Acetate
0.02560000



dimethyl-, 1-acetate, (2Z)-

106.
105-87-3
2,6-Octadien-1-ol, 3,7-
Geranyl acetate
0.02560000



dimethyl-, 1-acetate, (2E)-

107.
68141-17-3
Undecane, 1,1-dimethoxy-
Methyl Nonyl
0.02550000



2-methyl-
Acetaldehyde Dimethyl




Acetal

108.
2206-94-2
Benzenemethanol, α-
Indocolore
0.02550000



methylene-, 1-acetate

109.
10528-67-3
Cyclohexanepropanol, α-
Cyclohexylmagnol
0.02550000



methyl-

110.
123-11-5
Benzaldehyde, 4-methoxy-
Anisic Aldehyde
0.02490000

111.
57576-09-7
Cyclohexanol, 5-methyl-2-
Iso Pulegol Acetate
0.02480000



(1-methylethenyl)-, 1-



acetate, (1R,2S,5R)-

112.
51566-62-2
6-Octenenitrile, 3,7-
Citronellyl Nitrile
0.02470000



dimethyl-

113.
60335-71-9
2H-Pyran, 3,6-dihydro-4-
Rosyrane Super
0.02470000



methyl-2-phenyl-

114.
30385-25-2
6-Octen-2-ol, 2,6-
Dihydromyrcenol
0.02440000



dimethyl-

115.
101-84-8
Benzene, 1,1′-oxybis-
Diphenyl Oxide
0.02230000

116.
136-60-7
Benzoic acid, butyl ester
Butyl Benzoate
0.02170000

117.
93939-86-7
5,8-Methano-2H-1-
Rhuboflor
0.02120000



benzopyran, 6-



ethylideneoctahydro-

118.
83926-73-2
Cyclohexanepropanol, α,α-
Coranol
0.02100000



dimethyl-

119.
125109-85-5
Benzenepropanal, β-
Florhydral
0.02070000



methyl-3-(1-methylethyl)-

120.
104-21-2
Benzenemethanol, 4-
Anisyl Acetate
0.02050000



methoxy-, 1-acetate

121.
1365-19-1
2-Furanmethanol, 5-
Linalool Oxide
0.02050000



ethenyltetrahydro-α,α,5-



trimethyl-

122.
137-03-1
Cyclopentanone, 2-heptyl-
Frutalone
0.02040000

123.
2563-07-7
Phenol, 2-ethoxy-4-
Ultravanil
0.02030000



methyl-

124.
1128-08-1
2-Cyclopenten-1-one, 3-
Dihydrojasmone
0.02020000



methyl-2-pentyl-

125.
7493-57-4
Benzene, [2-(1-
Acetaldehyde
0.01990000



propoxyethoxy)ethyl]-

126.
141-25-3
7-Octen-1-ol, 3,7-
Rhodinol
0.01970000



dimethyl-

127.
216970-
Bicyclo[4.3.1]decane, 3-
3-Methoxy-7,7-dimethyl-
0.01960000


21-7
methoxy-7,7-dimethyl-10-
10-methylenebicyclo[4.3.1]decane



methylene-

128.
319002-92-1
Propanoic acid, 2-(1,1-
Sclareolate ®
0.01960000



dimethylpropoxy)-, propyl



ester, (2S)-

129.
85-91-6
Benzoic acid, 2-
Dimethyl anthranilate
0.01930000



(methylamino)-, methyl



ester

130.
13828-37-0
Cyclohexanemethanol, 4-
Mayol
0.01920000



(1-methylethyl)-, cis-

131.
26330-65-4
(E)-6-ethyl-3-methyloct-6-
Super Muguet
0.01850000



en-1-ol

132.
7540-51-4
6-Octen-1-ol, 3,7-
L-Citronellol
0.01830000



dimethyl-, (3S)-

133.
106-22-9
6-Octen-1-ol, 3,7-
Citronellol
0.01830000



dimethyl-

134.
543-39-5
7-Octen-2-ol, 2-methyl-6-
Myrcenol
0.01820000



methylene-

135.
7775-00-0
Benzenepropanal, 4-(1-
Cyclemax
0.01820000



methylethyl)-

136.
18479-54-4
4,6-Octadien-3-ol, 3,7-
Muguol
0.01800000



dimethyl-

137.
29214-60-6
Octanoic acid, 2-acetyl-,
Gelsone
0.01790000



ethyl ester

138.
1209-61-6
5-Oxatricyclo[8.2.0.04,6]
Tobacarol
0.01730000



dodecane, 4,9,12,12-



tetramethyl-

139.
57934-97-1
2-Cyclohexene-1-
Givescone
0.01710000



carboxylic acid, 2-ethyl-6,



6-dimethyl-, ethyl ester

140.
14901-07-6
3-Buten-2-one, 4-(2,6,6-
Beta-Ionone
0.01690000



trimethyl-1-cyclohexen-1-



yl)-, (3E)-

141.
64001-15-6
4,7-Methano-1H-inden-5-
Dihydro Cyclacet
0.01630000



ol, octahydro-, 5-acetate

142.
95-41-0
2-Cyclopenten-1-one, 2-
Iso Jasmone T
0.01600000



hexyl-

143.
134-20-3
Benzoic acid, 2-amino-,
Methyl Anthranilate
0.01580000



methyl ester

144.
100-06-1
Ethanone, 1-(4-
Para Methoxy
0.01550000



methoxyphenyl)-
Acetophenone

145.
105-86-2
2,6-Octadien-1-ol, 3,7-
Geranyl Formate
0.01540000



dimethyl-, 1-formate, (2E)-

146.
154171-77-4
Spiro[1,3-dioxolane-2,
Ysamber K ®
0.01470000



8′(5′H)-[2H-2,4a]



methanonaphthalene],



hexahydro-1′,1′,5′,5′-



tetramethyl-, (2′S,4′aS,



8′aS)-(9CI)

147.
154171-76-3
Spiro[1,3-dioxolane-
Ysamber
0.01470000



2,8′(5′H)-[2H-



2,4a]methanonaphthalene],



hexahydro-1′,1′,5′,5′-



tetramethyl-

148.
127-41-3
3-Buten-2-one, 4-(2,6,6-
Alpha-Ionone
0.01440000



trimethyl-2-cyclohexen-1-



yl)-, (3E)-

149.
151-05-3
Benzeneethanol, α,α-
Dimethyl Benzyl Carbinyl
0.01390000



dimethyl-, 1-acetate
Acetate

150.
2500-83-6
4,7-Methano-1H-inden-5-
Flor Acetate
0.01370000



ol, 3a,4,5,6,7,7a-



hexahydro-, 5-acetate

151.
150-84-5
6-Octen-1-ol, 3,7-
Citronellyl acetate
0.01370000



dimethyl-, 1-acetate

152.
30310-41-9
2H-Pyran, tetrahydro-2-
Pelargene
0.01350000



methyl-4-methylene-6-



phenyl-

153.
68845-00-1
Bicyclo[3.3.1]nonane, 2-
Boisiris
0.01350000



ethoxy-2,6,6-trimethyl-9-



methylene-

154.
106-24-1
2,6-Octadien-1-ol, 3,7-
Geraniol
0.01330000



dimethyl-, (2E)-

155.
106-25-2
2,6-Octadien-1-ol, 3,7-
Nerol
0.01330000



dimethyl-, (2Z)-

156.
75975-83-6
Bicyclo[7.2.0]undec-4-
Vetyvenal
0.01280000



ene, 4,11,11-trimethyl-8-



methylene-, (1R,4E,9S)-

157.
19870-74-7
1H-3a,7-Methanoazulene,
Cedryl methyl ether
0.01280000



octahydro-6-methoxy-3,6,



8,8-tetramethyl-, (3R,3aS,



6S,7R,8aS)-

158.
87-44-5
Bicyclo[7.2.0]undec-4-
Caryophyllene Extra
0.01280000



ene, 4,11,11-trimethyl-8-



methylene-, (1R,4E,9S)-

159.
54440-17-4
1H-Inden-1-one, 2,3-
Safraleine
0.01260000



dihydro-2,3,3-trimethyl-

160.
110-98-5
2-Propanol, 1,1′-oxybis-
Dipropylene Glycol
0.01250000

161.
41890-92-0
2-Octanol, 7-methoxy-3,7-
Osyrol ®
0.01250000



dimethyl-

162.
71077-31-1
4,9-Decadienal, 4,8-
Floral Super
0.01230000



dimethyl-

163.
65-85-0
Benzoic Acid
Benzoic Acid
0.01220000

164.
61444-38-0
3-Hexenoic acid, (3Z)-3-
cis-3-hexenyl-cis-3-
0.01220000



hexen-1-yl ester, (3Z)-
hexenoate

165.
116044-44-1
Bicyclo[2.2.1]hept-5-ene-
Herbanate
0.01210000



2-carboxylic acid, 3-(1-



methylethyl)-, ethyl ester,



(1R,2S,3S,4S)-rel-

166.
104-54-1
2-Propen-1-ol, 3-phenyl-
Cinnamic Alcohol
0.01170000

167.
78-35-3
Propanoic acid, 2-methyl-,
Linalyl Isobutyrate
0.01170000



1-ethenyl-1,5-dimethyl-4-



hexen-1-yl ester

168.
23495-12-7
Ethanol, 2-phenoxy-, 1-
Phenoxy Ethyl Propionate
0.01130000



propanoate

169.
103-26-4
2-Propenoic acid, 3-
Methyl Cinnamate
0.01120000



phenyl-, methyl ester

170.
67634-14-4
Benzenepropanal, 2-ethyl-
Florazon (ortho-isomer)
0.01110000



α,α-dimethyl-

171.
5454-19-3
Propanoic acid, decyl ester
N-Decyl Propionate
0.01100000

172.
93-16-3
Benzene, 1,2-dimethoxy-
Methyl Iso Eugenol
0.01100000



4-(1-propen-1-yl)-

173.
81782-77-6
3-Decen-5-ol, 4-methyl-
4-Methyl-3-decen-5-ol
0.01070000

174.
67845-30-1
Bicyclo[2.2.2]oct-5-ene-2-
Maceal
0.01060000



carboxaldehyde, 6-methyl-



8-(1-methylethyl)-

175.
97-53-0
Phenol, 2-methoxy-4-(2-
Eugenol
0.01040000



propen-1-yl)-

176.
120-57-0
1,3-Benzodioxole-5-
Heliotropin
0.01040000



carboxaldehyde

177.
93-04-9
Naphthalene, 2-methoxy-
Beta Naphthyl Methyl
0.01040000




Ether Extra 99

178.
4826-62-4
2-Dodecenal
2 Dodecene-1-al
0.01020000

179.
20407-84-5
2-Dodecenal, (2E)-
Aldehyde Mandarin
0.01020000

180.
5462-06-6
Benzenepropanal, 4-
Canthoxal
0.01020000



methoxy-α-methyl-

181.
94-60-0
1,4-Cyclohexanedicarboxylic
Dimethyl 1,4-
0.01020000



acid, 1,4-dimethyl ester
cyclohexanedicarboxylate

182.
57378-68-4
2-Buten-1-one, 1-(2,6,6-
delta-Damascone
0.01020000



trimethyl-3-cyclohexen-1-



yl)-

183.
17283-81-7
2-Butanone, 4-(2,6,6-
Dihydro Beta Ionone
0.01020000



trimethyl-1-cyclohexen-1-



yl)-

184.
1885-38-7
2-Propenenitrile, 3-phenyl-,
Cinnamalva
0.01010000



(2E)-

185.
103-48-0
Propanoic acid, 2-methyl-,
Phenyl Ethyl Iso Butyrate
0.00994000



2-phenylethyl ester

186.
488-10-8
2-Cyclopenten-1-one, 3-
Cis Jasmone
0.00982000



methyl-2-(2Z)-2-penten-1-



yl-

187.
7492-67-3
Acetaldehyde, 2-[(3,7-
Citronellyloxyacetaldehyde
0.00967000



dimethyl-6-octen-1-yl)



oxy]-

188.
68683-20-5
1-Cyclohexene-1-ethanol,
Iso Bergamate
0.00965000



4-(1-methylethyl)-, 1-



formate

189.
3025-30-7
2,4-Decadienoic acid,
Ethyl 2,4-Decadienoate
0.00954000



ethyl ester, (2E,4Z)-

190.
103-54-8
2-Propen-1-ol, 3-phenyl-,
Cinnamyl Acetate
0.00940000



1-acetate

191.
18127-01-0
Benzenepropanal, 4-(1,1-
Bourgeonal
0.00934000



dimethylethyl)-

192.
3738-00-9
Naphtho[2,1-b]furan,
Ambrox ® or Cetalox ® or
0.00934000



dodecahydro-3a,6,6,9a-
Synambran



tetramethyl-

193.
51519-65-4
1,4-Methanonaphthalen-
Tamisone
0.00932000



5(1H)-one, 4,4a,6,7,8,8a-



hexahydro-

194.
148-05-1
Dodecanoic acid, 12-
Dodecalactone
0.00931000



hydroxy-, λ-lactone (6CI,



7CI); 1,12-

195.
6790-58-5
(3aR,5aS,9aS,9bR)-
Ambronat ® or Ambroxan ®
0.00930000



3a,6,6,9a-tetramethyl-



2,4,5,5a,7,8,9,9b-



octahydro-1H-



benzo[e][1]benzofuran

196.
86-26-0
1,1′-Biphenyl, 2-methoxy-
Methyl Diphenyl Ether
0.00928000

197.
68738-94-3
2-
Cyclomyral ®
0.00920000



Naphthalenecarboxaldehyde,



octahydro-8,8-



dimethyl

198.
2705-87-5
Cyclohexanepropanoic
Allyl Cyclohexane
0.00925000



acid, 2-propen-1-yl ester
Propionate

199.
7011-83-8
2(3H)-Furanone, 5-
Lactojasmone ®
0.00885000



hexyldihydro-5-methyl-

200.
61792-11-8
2,6-Nonadienenitrile, 3,7-
Lemonile ®
0.00884000



dimethyl-

201.
692-86-4
10-Undecenoic acid, ethyl
Ethyl Undecylenate
0.00882000



ester

202.
103-95-7
Benzenepropanal, α-
Cymal
0.00881000



methyl-4-(1-methylethyl)-

203.
13019-22-2
9-Decen-1-ol
Rosalva
0.00879000

204.
94201-19-1
1-Oxaspiro[4.5]decan-2-
Methyl Laitone 10% TEC
0.00872000



one, 8-methyl-

205.
104-61-0
2(3H)-Furanone, dihydro-
γ-Nonalactone
0.00858000



5-pentyl-

206.
706-14-9
2(3H)-Furanone, 5-
γ-Decalactone
0.00852000



hexyldihydro-

207.
24720-09-0
2-Buten-1-one, 1-(2,6,6-
α-Damascone
0.00830000



trimethyl-2-cyclohexen-1-



yl)-, (2E)-

208.
39872-57-6
2-Buten-1-one, 1-(2,4,4-
Isodamascone
0.00830000



trimethyl-2-cyclohexen-1-



yl)-, (2E)-

209.
705-86-2
2H-Pyran-2-one,
Decalactone
0.00825000



tetrahydro-6-pentyl-

210.
67634-15-5
Benzenepropanal, 4-ethyl-
Floralozone
0.00808000



α,α-dimethyl-

211.
40527-42-2
1,3-Benzodioxole, 5-
Heliotropin Diethyl Acetal
0.00796000



(diethoxymethyl)-

212.
56973-85-4
4-Penten-1-one, 1-(5,5-
Neobutenone α
0.00763000



dimethyl-1-cyclohexen-1-



yl)-

213.
128-51-8
Bicyclo[3.1.1]hept-2-ene-
Nopyl Acetate
0.00751000



2-ethanol, 6,6-dimethyl-,



2-acetate

214.
103-36-6
2-Propenoic acid, 3-
Ethyl Cinnamate
0.00729000



phenyl-, ethyl ester

215.
5182-36-5
1,3-Dioxane, 2,4,6-
Floropal ®
0.00709000



trimethyl-4-phenyl-

216.
42604-12-6
Cyclododecane,
Boisambrene
0.00686000



(methoxymethoxy)-

217.
33885-52-8
Bicyclo[3.1.1]hept-2-ene-
Pinyl Iso Butyrate Alpha
0.00685000



2-propanal, α,α,6,6-



tetramethyl-

218.
92015-65-1
2(3H)-Benzofuranone,
Natactone
0.00680000



hexahydro-3,6-dimethyl-

219.
63767-86-2
Cyclohexanemethanol, α-
Mugetanol
0.00678000



methyl-4-(1-methylethyl)-

220.
3288-99-1
Benzeneacetonitrile, 4-(1,
Marenil CI
0.00665000



1-dimethylethyl)-

221.
35044-68-9
2-Buten-1-one, 1-(2,6,6-
beta-Damascone
0.00655000



trimethyl-1-cyclohexen-1-



yl)-

222.
41724-19-0
1,4-Methanonaphthalen-
Plicatone
0.00652000



6(2H)-one, octahydro-7-



methyl-

223.
75147-23-8
Bicyclo[3.2.1]octan-8-one,
Buccoxime ®
0.00647000



1,5-dimethyl-, oxime

224.
25634-93-9
2-Methyl-5-phenylpentan-
Rosaphen ® 600064
0.00637000



1-ol

225.
55066-48-3
3-Methyl-5-
Phenyl Hexanol
0.00637000



phenylpentanol

226.
495-62-5
Cyclohexene, 4-(1,5-
Bisabolene
0.00630000



dimethyl-4-hexen-1-



ylidene)-1-methyl-

227.
2785-87-7
Phenol, 2-methoxy-4-
Dihydro Eugenol
0.00624000



propyl-

228.
87-19-4
Benzoic acid, 2-hydroxy-,
Iso Butyl Salicylate
0.00613000



2-methylpropyl ester

229.
4430-31-3
2H-1-Benzopyran-2-one,
Octahydro Coumarin
0.00586000



octahydro-

230.
38462-22-5
Cyclohexanone, 2-(1-
Ringonol 50 TEC
0.00585000



mercapto-1-methylethyl)-



5-methyl-

231.
77-83-8
2-Oxiranecarboxylic acid,
Ethyl Methyl
0.00571000



3-methyl-3-phenyl-, ethyl
Phenyl Glycidate



ester

232.
37677-14-8
3-Cyclohexene-1-
Iso Hexenyl Cyclohexenyl
0.00565000



carboxaldehyde, 4-(4-
Carboxaldehyde



methyl-3-penten-1-yl)-

233.
103-60-6
Propanoic acid, 2-methyl-,
Phenoxy Ethyl iso-
0.00562000



2-phenoxyethyl ester
Butyrate

234.
18096-62-3
Indeno[1,2-d]-1,3-dioxin,
Indoflor ®
0.00557000



4,4a,5,9b-tetrahydro-

235.
63500-71-0
2H-Pyran-4-ol, tetrahydro-
Florosa Q/Florol
0.00557000



4-methyl-2-(2-



methylpropyl)-

236.
65405-84-7
Cyclohexanebutanal, α,2,
Cetonal ®
0.00533000



6,6-tetramethyl-

237.
171102-41-3
4,7-Methano-1H-inden-6-
Flor Acetate
0.00530000



ol, 3a,4,5,6,7,7a-



hexahydro-8,8-dimethyl-,



6-acetate

238.
10339-55-6
1,6-Nonadien-3-ol, 3,7-
Ethyl linalool
0.00520000



dimethyl-

239.
23267-57-4
3-Buten-2-one, 4-(2,2,6-
Ionone Epoxide Beta
0.00520000



trimethyl-7-



oxabicyclo[4.1.0]hept-1-



yl)-

240.
97-54-1
Phenol, 2-methoxy-4-(1-
Isoeugenol
0.00519000



propen-1-yl)-

241.
67663-01-8
2(3H)-Furanone, 5-
Peacholide
0.00512000



hexyldihydro-4-methyl-

242.
33885-52-8
Bicyclo[3.1.1]hept-2-ene-
Pinyl Iso Butyrate Alpha
0.00512000



2-propanal, α,α,6,6-



tetramethyl-

243.
23696-85-7
2-Buten-1-one, 1-(2,6,6-
Damascenone
0.00503000



trimethyl-1,3-



cyclohexadien-1-yl)-

244.
80-71-7
2-Cyclopenten-1-one, 2-
Maple Lactone
0.00484000



hydroxy-3-methyl-

245.
67662-96-8
Propanoic acid, 2,2-
Pivarose Q
0.00484000



dimethyl-, 2-phenylethyl



ester

246.
2437-25-4
Dodecanenitrile
Clonal
0.00480000

247.
141-14-0
6-Octen-1-ol, 3,7-
Citronellyl Propionate
0.00469000



dimethyl-, 1-propanoate

248.
54992-90-4
3-Buten-2-one, 4-(2,2,3,6-
Myrrhone
0.00460000



tetramethylcyclohexyl)-

249.
55066-49-4
Benzenepentanal, β-
Mefranal
0.00455000



methyl-

250.
7493-74-5
Acetic acid, 2-phenoxy-,
Allyl Phenoxy Acetate
0.00454000



2-propen-1-yl ester

251.
80-54-6
Benzenepropanal, 4-(1,1-
Lilial ®
0.00444000



dimethylethyl)-α-methyl-

252.
86803-90-9
4,7-Methano-1H-indene-2-
Scentenal ®
0.00439000



carboxaldehyde,



octahydro-5-methoxy-

253.
68991-97-9
2-Naphthalenecarboxaldehyde,
Melafleur
0.00436000



1,2,3,4,5,6,7,8-



octahydro-8,8-dimethyl-

254.
18871-14-2
Pentitol, 1,5-anhydro-2,4-
Jasmal
0.00434000



dideoxy-2-pentyl-, 3-



acetate

255.
58567-11-6
Cyclododecane,
Boisambren Forte
0.00433000



(ethoxymethoxy)-

256.
94400-98-3
Naphth[2,3-b]oxirene,
Molaxone
0.00425000



1a,2,3,4,5,6,7,7a-



octahydro-1a,3,3,4,6,6-



hexamethyl-,



(1aR,4S,7aS)-rel-

257.
79-69-6
3-Buten-2-one, 4-(2,5,6,6-
alpha-Irone
0.00419000



tetramethyl-2-cyclohexen-



1-yl)-

258.
65442-31-1
Quinoline, 6-(1-
Iso Butyl Quinoline
0.00408000



methylpropyl)-

259.
87731-18-8
Carbonic acid, 4-
Violiff
0.00401000



cycloocten-1-yl methyl



ester

260.
173445-65-3
1H-Indene-5-propanal, 2,
Hivernal (A-isomer)
0.00392000



3-dihydro-3,3-dimethyl-

261.
23911-56-0
Ethanone, 1-(3-methyl-2-
Nerolione
0.00383000



benzofuranyl)-

262.
52474-60-9
3-Cyclohexene-1-
Precyclemone B
0.00381000



carboxaldehyde, 1-methyl-



3-(4-methyl-3-penten-1-yl)-

263.
139539-66-5
6-Oxabicyclo[3.2.1]
Cassifix
0.00381000



octane, 5-methyl-1-(2,2,3-



trimethyl-3-cyclopenten-1-



yl)-

264.
80858-47-5
Benzene, [2-
Phenafleur
0.00380000



(cyclohexyloxy)ethyl]-

265.
32764-98-0
2H-Pyran-2-one,
Jasmolactone
0.00355000



tetrahydro-6-(3-penten-1-



yl)-

266.
78417-28-4
2,4,7-Decatrienoic acid,
Ethyl 2,4,7-decatrienoate
0.00353000



ethyl ester

267.
140-26-1
Butanoic acid, 3-methyl-,
Beta Phenyl Ethyl
0.00347000



2-phenylethyl ester
Isovalerate

268.
105-90-8
2,6-Octadien-1-ol, 3,7-
Geranyl Propionate
0.003360000



dimethyl-, 1-propanoate,



(2E)-

269.
41816-03-9
Spiro[1,4-
Rhubofix ®
0.00332000



methanonaphthalene-



2(1H),2′-oxirane], 3,4,4a,



5,8,8a-hexahydro-3′,7-



dimethyl-

270.
7070-15-7
Ethanol, 2-[[(1R,2R,4R)-1,
Arbanol
0.00326000



7,7-trimethylbicyclo[2.2.1]



hept-2-yl]oxy]-, rel-

271.
93-29-8
Phenol, 2-methoxy-4-(1-
Iso Eugenol Acetate
0.00324000



propen-1-yl)-, 1-acetate

272.
476332-65-7
2H-Indeno[4,5-b]furan,
Amber Xtreme Compound 1
0.00323000



decahydro-2,2,6,6,7,8,8-



heptamethyl-

273.
68901-15-5
Acetic acid, 2-
Cyclogalbanate
0.00323000



(cyclohexyloxy)-, 2-



propen-1-yl ester

274.
107-75-5
Octanal, 7-hydroxy-3,7-
Hydroxycitronellal
0.00318000



dimethyl-

275.
68611-23-4
Naphtho[2,1-b]furan, 9b-
Grisalva
0.00305000



ethyldodecahydro-3a,7,7-



trimethyl-

276.
313973-37-4
1,6-Heptadien-3-one, 2-
Pharaone
0.00298000



cyclohexyl-

277.
137-00-8
5-Thiazoleethanol, 4-
Sulfurol
0.00297000



methyl-

278.
7779-30-8
1-Penten-3-one, 1-(2,6,6-
Methyl Ionone
0.00286000



trimethyl-2-cyclohexen-1-



yl)-

279.
127-51-5
3-Buten-2-one, 3-methyl-
Isoraldeine Pure
0.00282000



4-(2,6,6-trimethyl-2-



cyclohexen-1-yl)-

280.
72903-27-6
1,4-Cyclohexanedicarboxylic
Fructalate ™
0.00274000



acid, 1,4-diethyl ester

281.
7388-22-9
3-Buten-2-one, 4-(2,2-
Ionone Gamma Methyl
0.00272000



dimethyl-6-



methylenecyclohexyl)-3-



methyl-

282.
104-67-6
2(3H)-Furanone, 5-
gamma-Undecalactone
0.00271000



heptyldihydro-
(racemic)

283.
1205-17-0
1,3-Benzodioxole-5-
Helional
0.00270000



propanal, α-methyl-

284.
33704-61-9
4H-Inden-4-one, 1,2,3,5,6,
Cashmeran
0.00269000



7-hexahydro-1,1,2,3,3-



pentamethyl-

285.
36306-87-3
Cyclohexanone, 4-(1-
Kephalis
0.00269000



ethoxyethenyl)-3,3,5,5-



tetramethyl-

286.
97384-48-0
Benzenepropanenitrile, α-
Citrowanil ® B
0.00265000



ethenyl-α-methyl-

287.
141-13-9
9-Undecenal, 2,6,10-
Adoxal
0.00257000



trimethyl-

288.
2110-18-1
Pyridine, 2-(3-
Corps Racine VS
0.00257000



phenylpropyl)-

289.
27606-09-3
Indeno[1,2-d]-1,3-dioxin,
Magnolan
0.00251000



4,4a,5,9b-tetrahydro-2,4-



dimethyl-

290.
67634-20-2
Propanoic acid, 2-methyl-,
Cyclabute
0.00244000



3a,4,5,6,7,7a-hexahydro-4,



7-methano-1H-inden-5-yl



ester

291.
65405-72-3
1-Naphthalenol, 1,2,3,4,
Oxyoctaline Formate
0.00236000



4a,7,8,8a-octahydro-2,4a,



5,8a-tetramethyl-, 1-



formate

292.
122-40-7
Heptanal, 2-
Amyl Cinnamic Aldehyde
0.00233000



(phenylmethylene)-

293.
103694-68-4
Benzenepropanol, β,β,3-
Majantol ®
0.00224000



trimethyl-

294.
13215-88-8
2-Cyclohexen-1-one, 4-(2-
Tabanone Coeur
0.00223000



buten-1-ylidene)-3,5,5-



trimethyl-

295.
25152-85-6
3-Hexen-1-ol, 1-benzoate,
Cis-3-Hexenyl Benzoate
0.00203000



(3Z)-

296.
406488-30-0
2-Ethyl-N-methyl-N-(m-
Paradisamide
0.00200000



tolyl)butanamide

297.
121-33-5
Benzaldehyde, 4-hydroxy-
Vanillin
0.00194000



3-methoxy-

298.
77-54-3
1H-3a,7-Methanoazulen-
Cedac
0.00192000



6-ol, octahydro-3,6,8,8-



tetramethyl-, 6-acetate,



(3R,3aS,6R,7R,8aS)-

299.
76842-49-4
4,7-Methano-1H-inden-6-
Frutene
0.00184000



ol, 3a,4,5,6,7,7a-



hexahydro-8,8-dimethyl-,



6-propanoate

300.
121-39-1
2-Oxiranecarboxylic acid,
Ethyl Phenyl Glycidate
0.00184000



3-phenyl-, ethyl ester

301.
211299-54-6
4H-4a,9-
Ambrocenide ®
0.00182000



Methanoazuleno[5,6-d]-1,



3-dioxole, octahydro-2,2,



5,8,8,9a-hexamethyl-,



(4aR,5R,7aS,9R)-

302.
285977-85-7
(2,5-Dimethyl-1,3-
Lilyflore
0.00180000



dihydroinden-2-



yl)methanol

303.
10094-34-5
Butanoic acid, 1,1-
Dimethyl Benzyl Carbinyl
0.00168000



dimethyl-2-phenylethyl
Butyrate



ester

304.
40785-62-4
Cyclododeca[c]furan, 1,3,
Muscogene
0.00163000



3a,4,5,6,7,8,9,10,11,13a-



dodecahydro-

305.
75490-39-0
Benzenebutanenitrile, α,α,
Khusinil
0.00162000



γ-trimethyl-

306.
55418-52-5
2-Butanone, 4-(1,3-
Dulcinyl
0.00161000



benzodioxol-5-yl)-

307.
3943-74-6
Benzoic acid, 4-hydroxy-
Carnaline
0.00157000



3-methoxy-, methyl ester

308.
72089-08-8
3-Cyclopentene-1-butanol,
Brahmanol ®
0.00154000



β,2,2,3-tetramethyl-



2-Methyl-4-(2,2,3-



trimethyl-3-cyclopenten-1-



yl)butanol

309.
3155-71-3
2-Butenal, 2-methyl-4-(2,
Boronal
0.00147000



6,6-trimethyl-1-



cyclohexen-1-yl)-

310.
2050-08-0
Benzoic acid, 2-hydroxy-,
Amyl Salicylate
0.00144000



pentyl ester

311.
41199-20-6
2-Naphthalenol,
Ambrinol
0.00140000



decahydro-2,5,5-trimethyl-

312.
12262-03-2
ndecanoic acid, 3-
Iso Amyl Undecylenate
0.00140000



methylbutyl ester

313.
107-74-4
1,7-Octanediol, 3,7-
Hydroxyol
0.00139000



dimethyl-

314.
91-64-5
2H-1-Benzopyran-2-one
Coumarin
0.00130000

315.
68901-32-6
1,3-Dioxolane, 2-[6-
Glycolierral
0.00121000



methyl-8-(1-methylethyl)



bicyclo[2.2.2]oct-5-en-2-



yl]-

316.
68039-44-1
Propanoic acid, 2,2-
Pivacyclene
0.00119000



dimethyl-, 3a,4,5,6,7,7a-



hexahydro-4,7-methano-



1H-inden-6-yl ester

317.
106-29-6
Butanoic acid, (2E)-3,7-
Geranyl Butyrate
0.00116000



dimethyl-2,6-octadien-1-yl



ester

318.
5471-51-2
2-Butanone, 4-(4-
Raspberry ketone
0.00106000



hydroxyphenyl)-

319.
109-42-2
10-Undecenoic acid, butyl
Butyl Undecylenate
0.00104000



ester



*Vapor Pressures are acquired as described in the Test Methods Section.

**Origin: Same as for Table 1 hereinabove.

























































































































































































































































































































































































































































































































































































































































































































































































Exemplary moderate volatile fragrance materials selected from the group of Table 2 Moderate Volatile Fragrance Materials are preferred. However, it is understood by one skilled in the art that other moderate volatile fragrance materials, not recited in Table 2, would also fall within the scope of the present invention, so long as they have a vapor pressure of 0.1 to 0.001 Torr at 25° C.
Preferably, the compositions of the present invention, wherein: (i)(b) the moderate volatile fragrance material is selected from the group of Table 2 Moderate Volatile Fragrance Materials 1-9, 11-12, 14-15, 17-18, 20-25, 27-35, 37-38, 39-43, 45-46, 48-53, 55-61, 63, 65, 67-71, 73-77, 79, 81-84, 86-91, 93-122, 124-125, 130-131, 133-135, 137, 139-145, 147-149, 151, 153-155, 157, 161-162, 164-169, 171-191, 193, 195-198, 200-203, 205-215, 218-219, 221, 223-241, 243, 245-250, 252-255, 257-262, 264-265, 267-268, 272, 273-276, 279-300, 302-304, 306, 308-310, 312-319, and mixtures thereof, and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 1-5, and mixtures thereof.
Preferably, the compositions of the present invention, wherein: (i)(a) the moderate volatile fragrance material is selected from the group consisting of Table 2 Moderate Volatile Fragrance Materials 1, 3, 4, 6, 7, 9, 11-12, 14, 15, 17-18, 20-25, 30-31, 34-35, 37-38, 41-42, 45-46, 49, 51-53, 55, 57-59, 65-70, 73, 75-77, 79-80, 82, 86-89, 91-94, 98, 101-107, 111-113, 115-122, 124-125, 130-133, 135, 137, 139-143, 145, 147-149, 151, 153-155, 157-159, 161-162, 164-168, 171-180, 182-183, 187-191, 193, 195-198, 200-203, 205-213, 218-219, 221-222, 224-229, 231-241, 243, 245-250, 252, 253, 254-255, 257-263, 264-265, 267-269, 271, 273-276, 279-300, 302-304, 306, 308-310, 312, 314-319, and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 6-8, and mixtures thereof.
Preferably, the compositions of the present invention, the low volatile fragrance material is selected from the group (as described herein above), and wherein this group of low volatile fragrance material has at least about 20 wt %, at least about 30 wt %, at least about 40 wt %, at least about 50 wt %, at least about 60 wt %, or at least about 70 wt %, relative to the total weight of the low volatile fragrance material.
(iii) High Volatile Fragrance Materials
Preferable examples of high volatile fragrance materials having a vapor pressure greater than 0.1 (0.0133 kPa) Torr at 25° C. are provided in Table 3 High Volatile Fragrance Materials. Preferably, the high volatile fragrance material is selected from at least 1 material, or at least 2 materials, or at least 3 materials, or at least 5 materials, or at least 7 high volatile fragrance materials as disclosed in Table 3.








Exemplary high volatile fragrance materials selected from the group of Table 3 High Volatile Fragrance Materials are preferred. However, it is understood by one skilled in the art that other high volatile fragrance materials, not recited in Table 3, would also fall within the scope of the present invention, so long as they have a vapor pressure of greater than 0.1 Torr (0.0133 kPa) at 25° C.
Preferably, the compositions of the present invention, wherein: (i)(c) the high volatile fragrance material is selected from the group of Table 3 High Volatile Fragrance Materials 1, 2, 6, 8, 9, 12, 14, 19, 36, 39, 46, 47, 56, 57, 58, 60, 62, 74, 78, 93, 94, 96, 100, 106, 111, 117, 119, 120, 128, 129, 131-135 and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 1-5, and mixtures thereof.
Preferably, the compositions of the present invention, wherein: (i)(c) the high volatile fragrance material is selected from the group consisting of Table 3 high Volatile Fragrance Materials 1, 2, 6, 8, 9, 12, 14, 19, 36, 39, 46, 47, 56, 57, 58, 60, 62, 74, 78, 93, 94, 96, 100, 106, 111, 117, 119, 120, 128, 129, 131-135, and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 6-8, and mixtures thereof.
Preferably, the compositions of the present invention, the high volatile fragrance material is selected from the group (as described herein above), and wherein this group of high volatile fragrance material has at least about 20 wt %, at least about 30 wt %, at least about 40 wt %, at least about 50 wt %, at least about 60 wt %, or at least about 70 wt %, relative to the total weight of the high volatile fragrance material.
Fragrance Modulators
In one aspect, compositions of the present invention comprise at least one substantially non-odorous modulator selected from the group consisting of:
(a) Methyl Glucoside Polyol; Ethyl Glucoside Polyol; Propyl Glucoside Polyol; and their mixtures; (b) Isocetyl Alcohol; (c) PPG-3 Myristyl Ether; Neopentyl Glycol Diethylhexanoate; and their mixtures; (d) Sucrose Laurate, Sucrose Dilaurate, Sucrose Myristate, Sucrose Palmitate, Sucrose Stearate, Sucrose Distearate, Sucrose Tristearate, and mixtures thereof; (e) Trimethylcyclohexane derivatives having the formula (I):














wherein:
n is 0, 1 or 2; A is C═O or CH—OH; R 1a is hydrogen or methyl; R 2a is a C 2 -C 10 hydrocarbon group; and ------ is a saturated or unsaturated carbon-carbon bond;



(f) L-menthoxy ether derivatives having the formula (II):

















wherein:
m is 0, 1 or 2; B is hydrogen or OH; and C is hydrogen or methyl;



(g) Tetra-hydronaphthalene derivatives having the formula (III):

















wherein:
R 1b is hydrogen or methyl; and R 2b is alkyl;



(h) Hyaluronic acid disaccharide sodium salt, sodium hyaluronate and their mixtures;
(i) Ether derivatives having the formula (IV) or formula (V):




C 5 H l O m —(OR 1c ) n (IV)
wherein:
C 5 H l O m is a pentose residue, wherein l is an integer from 6 to 9, and m is an integer from 1 to 4; n is an integer from 1 to 4; and R 1c is C 4 -C 20 hydrocarbon group; and


C 6 H x O y —(OR 1d ) z (V)
wherein:
C 6 H x O y is a hexose residue, wherein x is an integer from 7 to 11, and y is an integer from 1 to 5; z is an integer from 1 to 5; and R 1d is C 4 -C 20 hydrocarbon group; and
(j) Diethylene Glycol Ether derivatives having the formula (VI) or formula (VII):

C 5 H c O d —(OCH 2 CH 2 —O—CH 2 CH 2 —O—R 1e ) e (VI)
wherein:
C 5 H c O d is a pentose residue, wherein c is an integer from 6 to 8, and d is an integer from 1 to 3; e is an integer from 2 to 4; and R 1e is C 1 -C 6 alkyl group; and


C 6 H f O g —(OCH 2 CH 2 —O—CH 2 CH—O—R 1f ) h (VII)
wherein:
C 6 H f O g is a hexose residue, wherein f is an integer from 7 to 10, and g is an integer from 1 to 4; h is an integer from 2 to 5; and R 1f is C 1 -C 6 alkyl group;
(k) Hydroquinone Glycoside derivatives having the formula (VIII):














wherein:
R 1g is selected from the group consisting of: (i) pentose residue, hexose residue, aminosaccharide residue, uronic acid residue and their mixtures; (ii) methylated versions of group (i); and (iii) mixtures of groups (i) and (ii); and



(l) Propylene Glycol Propyl Ether; Dicetyl Ether; Polyglycerin-4 Ethers; Isoceteth-5; Isoceteth-7, Isoceteth-10; Isoceteth-12; Isoceteth-15; Isoceteth-20; Isoceteth-25; Isoceteth-30; Disodium Lauroamphodipropionate; Hexaethylene glycol monododecyl ether; and their mixtures;
(m) Neopentyl Glycol Diisononanoate; Cetearyl Ethylhexanoate; and their mixtures;
(n) Glyceryl Ether derivatives having the formula (IX):

















wherein:
R 1h is C 4 -C 12 aliphatic hydrocarbon group;



(o) Panthenol Ethyl Ether, DL-Panthenol and their mixtures;
(p) Aliphatic Dibasic Acid Diester derivatives having the formula (X):




R 1i OCO R2i COOR 3i (X)
wherein:
R 1i is C 4 -C 5 alkyl; R 2i is C 4 alkylene; and R 3i is C 4 -C 5 alkyl; and (q) Aliphatic Ether derivatives having the formula (XI):


R 4i —O—(CH(CH 3 )—CH 2 O) a —(CH 2 —CH 2 O) b —H (XI)
wherein:
a and b are integers such that the sum of a and b is from 1 to 4; and R 4i is an aliphatic chain comprising from 8 to 18 carbons;
(r) N-hexadecyl n-nonanoate, Noctadecyl n-nonanoate and their mixtures; (s) Tricyclodecane Amide derivatives selected from the group consisting of:
(i) the compounds of formula (XII):

















wherein:
X is selected from:



































t is 1 to 8;
Y is hydrogen,



























or a halogen; and
each R 1j is independently selected from a hydrogen, or C 1 -C 4 alkyl;




(ii) the compounds of formula (XIII):





















wherein:
each R 2j is independently selected from a hydrogen, methyl, ethyl or C 3 -C 18 alkyl, cycloalkyl or cycloheteroalkyl, with the proviso that both R 2e groups are not hydrogen; and



(iii) mixtures of the compounds of formulae (XII) and (XIII); and


(t) mixtures thereof.




Preferably, the substantially non-odorous fragrance modulator is selected from the group of materials disclosed in Table 4(a).





TABLE 4(a)



Substantially Non-Odorous Fragrance Modulators










CAS


No.
Group
Chemical Name
Number
Supplier









1.
(a)
PPG-10 Methyl Glucose Ether
61849-72-7
Lubrizol

2.

PPG-20 Methyl Glucose Ether 1
61849-72-7

3.

Ethoxylated Methyl Glucose Ether 2
68239-42-9

4.

Caprylyl/Capryl Glucoside 3
68515-73-1
BASF

5.

Undecyl Glucoside 3a
—
SEPPIC





(France)

6.
(b)
Isocetyl Alcohol 4
36653-82-4
Ashland





Speciality





Ingredients

7.
(c)
PPG-3 Myristyl Ether 5
—
Evonik

8.

Neopentyl Glycol Diethylhexanoate 6
28510-23-8
Lubrizol

9.
(d)
Sucrose Laurate
25339-99-5
Alfa Chemicals





Ltd. (UK)

10.

Sucrose dilaurate
25915-57-5
Alfa Chemicals





Ltd. (UK)

11.

Sucrose Myristate
27216-47-3
Mitsubishi





Chemicals

12.

Sucrose Palmitate
26446-38-8
Alfa Chemicals

13.

Sucrose Stearate
25168-73-4
Ltd. (UK)

14.

Sucrose Distearate
27195-16-0
Mitsubishi





Chemicals (JP)

15.

Sucrose Tristearate
27923063-3
Mitsubishi





Chemicals (JP)

16.
(e)
(E)-1-(2,2,6-trimethylcyclohexyl)oct-1-en-3-
—
Takasago



one 8

(Japan)

17.
(f)
2-(1-menthoxy)ethane-1-ol 9
—
Takasago

18.

1-(1-menthoxy)propane-2-ol 9
—
(Japan)

19.

3-(1-menthoxy)propane-1-ol 9
—

20.

3-(1-menthoxy)propane-1,2-diol 9
—

21.

2-methyl-3-(1-menthoxy)propane-1,2-diol 9
—

22.

4-(1-menthoxy) butane-1-ol 9
—

23.
(g)
1,1,4,4-tetramethyl-6-acetyl-7-formyl-1,2,3,4-
—
Givaudan



tetrahydronaphthalene 10

(Switzerland)

24.

1,1,2,4,4-pentamethyl-6-acetyl-7-formyl-
—



1,2,3,4-tetrahydronaphthalene 10

25.
(h)
Hyaluronic acid disaccharide sodium salt 11
9004-61-9
Sigma Aldrich

26.

Sodium Hyaluronate 11
9067-32-7
(UK)

27.
(i)
Mono-o-(linalyl)-glucopyranose 12
—
Kanebo (Japan)

28.

Di-o-(linalyl)-glucopyranose 12
—

29.

Tri-o-(linalyl)-glucopyranose 12
—

30.

Tetra-o-(linalyl)-glucopyranose 12
—

31.

Penta-o-(linalyl)-glucopyranose 12
—

32.

Mono-o-(cis-3-hexenyl)-glactopyranose 12
—

33.

Di-o-(cis-3-hexenyl)-glactopyranose 12
—

34.

Tri-o-(cis-3-hexenyl)-glactopyranose 12
—

35.

Tetra-o-(cis-3-hexenyl)-glactopyranose 12
—

36.

Penta-o-(cis-3-hexenyl)-glactopyranose 12
—

37.
(j)
Bis-O-(3,6-dioxadecanyl)-glucopyranose 13
—

38.

Tris-O-(3,6-dioxadecanyl)-glucopyranose 13
—

39.

Tetrakis-O-(3,6-dioxadecanyl)-glucopyranose 13
—

40.

Pentakis-O-(3,6-dioxadecanyl)-glucopyranose 13
—

41.

Bis-O-(3,6-dioxaoctanyl)-galactopyranose 13
—

42.

Tris-O-(3,6-dioxaoctanyl)-galactopyranose 13
—

43.

Tetrakis-O-(3,6-dioxaoctanyl)-galactopyranose 13
—

44.

Pentakis-O-(3,6-dioxaoctanyl)-galactopyranose 13
—

45.

Bis-O-(3,6-dioxaheptanyl)-xylopyranose 13
—

46.

Tris-O-(3,6-dioxaheptanyl)-xylopyranose 13
—

47.

Tetrakis-O-(3,6-dioxaheptanyl)-xylopyranose 13
—

48.

Bis-O-(3,6-dioxadodecanyl)-glucopyranose 13
—

49.

Tris-O-(3,6-dioxadodecanyl)-glucopyranose 13
—

50.

Tetrakis-O-(3,6-dioxadodecanyl)-glucopyranose 13
—

51.

Pentakis-O-(3,6-dioxadodecanyl)-
—



glucopyranose 13

52.
(k)
Hydroquinone beta-D-glycoside 14
497-76-7
Shiseido

53.
(l)
Propylene Glycol Propyl Ether
1569-01-3
Sigma Aldrich

54.

Dicetyl Ether
4113-12-6
(UK)

55.

Polyglycerin-4 Ethers
25618-55-7
Solvay





Chemicals

56.

Isoceteth-5
69364-63-2
Nihon

57.

Isoceteth-7
69364-63-2
Emulsion

58.

Isoceteth-10
69364-63-2
Company Ltd.

59.

Isoceteth-12
69364-63-2

60.

Isoceteth-15
69364-63-2

61.

Isoceteth-20
69364-63-2

62.

Isoceteth-25
69364-63-2

63.

Isoceteth-30
69364-63-2

64.

Disodium Lauroamphodipropionate
68929-04-4
Rhodia

65.

Hexaethylene glycol monododecyl ether 14b
3055-96-7
Sigma Aldrich





(UK)

66.
(m)
Neopentyl Glycol Diisononanoate 15
27841-07-2
Symrise

67.

Cetearyl Ethylhexnoate 16
90411-68-0
(Germany)

68.
(n)
2-ethylhexyloxypropanediol 17
70455-33-9
Takasago (JP)

69.
(o)
Panthenol Ethyl Ether 18
667-83-4
DSM





Nutritional





Products, Inc.





(USA)

70.

DL-Panthenol
16485-10-2
Roche Inc.





(USA)

71.
(p)
Diisobutyl Adipate 19
141-04-8
Sigma Aldrich

72.

Diisoamyl Adipate 19
6624-70-0
(UK)

73.
(q)
PPG-11 Stearyl Ether 19a
25231-21-4
Kao (JP)

74.
(r)
N-hexadecyl n-nonanoate 19b
72934-15-7
Symrise



(i.e., cetyl nonanoate)

(Germany)

75.

Noctadecyl n-nonanoate 19b
107647-



(i.e., stearyl nonanoate)
13-2

76.
(s)
methanone, (morphonyl)tricyclo[3.3.1.1 3,7 ]dec-
—
Unilever (UK)



1-yl- 20

77.

methanone, (piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-
—



1-yl- 20

78.

methanone, (pyrrolidinyl)tricyclo[3.3.1.1 3,7 ]dec-
—



1-yl 20

79.

methanone, (azetidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-
—



yl- 20

80.

methanone,
—



(hexahydroazepinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

81.

methanone, (4-cyano-
—



piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

82.

methanone, (4-amido-
—



piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

83.

methanone, (Tricyclo[3.3.1.1 3,7 ]decanyl)-N-
—



tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

84.

methanone,
—



(decahydroisoquinolinyl)tricyclo[3.3.1.1 3,7 ]dec-



1-yl- 20

85.

methanone,
—



(decahydroisoquinolinyl)tricyclo[3.3.1.1 3,7 ]dec-



1-yl- 20

86.

methanone,
—



(decahydroquinolinyl)tricyclo[3.3.1.1 3,7 ]dec-1-



yl- 20

87.

methanone, (3,3-dimethyl-1-
—



piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

88.

methanone, (2-methyl-1-
—



piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

89.

methanone, (4-methyl-1-
—



piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

90.

methanone, (3-methyl-1-
—



piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

91.

methanone, (3,5-dimethyl-1-
—



piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

92.

methanone, (4-methyl-4-ethy-
—



piperidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

93.

methanone, (3,3-diethyl-1-
—



pyrrolidinyl)tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

94.

methanone, (N,N-diisopropyl)
—



tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

95.

methanone, (3,3-dimethylbutylaminyl)
—



tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

96.

methanone, (2,2-dimethylpropylaminyl)
—



tricyclo[3.3.1.1 3,7 ]dec-1-yl- 20

97.

methanone, (1,1-dimethyl-3,3-
—



dimethylbutylaminyl) tricyclo[3.3.1.1 3,7 ]dec-1-



yl- 20

98.

methanone, (1,3-dimethyl-butylaminyl)
—



tricycle[3.3.1.1 3,7 ]dec-1-yl- 20

99.
(t)
Bis-methoxy PEG-13
936645-
PolymerExpert



PEG-438/PPG-110 SMDI Copolymer 21
35-1
S.A. (Pessac,





France)

100.
(u)
propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-
61791-12-6
Sigma Aldrich



methoxyphenyl}acetate 22

(US)

101.
(v)
3-((2-ethylhexyl)oxy)propane-1,2-diol 23
70445-33-9
—

102.

3-((2-propylheptyl)oxy)propane-1,2-diol 23
—
—

103.

1-amino-3-((2-ethylhexyl)oxy)propan-2-ol 23
99509-00-9
—



1 available as GLUCAM ™ P-20.

2 available as Glucam ™ E-20.

3 available as Plantacare ® 810 UP.

3a available as Simulsol ® SL 11W.

4 available as CERAPHYL ® ICA.

5 available as Tegosoft ® APM.

6 available as Schercemol ™ NGDO.

7 disclosed in U.S. Pat. No. 6,737,396B2 (Firmenich), column 1, lines 43-47.

8 diclosed as compound 1′i in U.S. Pat. No. 6,440,400B1 (Takasago Int. Corp.), col. 5.

8a diclosed in U.S. Pat. No. 4,313,855 (Dragoco Gerberding & Co. GmbH), col. 1, lines 12-13.

9 disclosed in U.S. Pat. No. 7,538,081B2 (Takasago Int. Corp.), column 7, lines 50-53.

10 disclosed in U.S. Pat. No. 6,147,049 (Givaudan Roure), col. 5, line 24, to col. 6, line 17.

11 disclosed in PCT Publication No. WO85/04803 (Diagnostic), pg. 2, line 1 to pg. 4, line 2.

12 disclosed in JP Patent No. 61-083114 (Kanebo).

13 disclosed in JP Patent No. 61-063612 (Kanebo).

14 disclosed in JP Patent No. 62-084010 (Shiseido).

14b available as: Laureth-6.

15 disclosed in U.S. Patent Publication No. 2011/0104089A1 (Symrise), para. [0001].

16 available as PCL-Liquid ® 100.

17 disclosed in U.S. Pat. No. 7,196,052 (Takasago Int. Corp.), col. 4, lines 34-35.

18 disclosed in EP Patent Publication No. 616800A2 (Givaudan), pg. 2, lines 12-25.

19 disclosed in U.S. Pat. No. 4,110,626 (Shiseido), column 3, lines 54-56.

19a disclosed in PCT Publication No. WO2014/155019 (LVMH).

19b disclosed in U.S. Pat. No. 9,050,261 (Symrise).

20 disclosed as compounds C1-C22 in WO2014/139952 (Unilever).

21 available as Expert Gel ® EG56.

22 available as Kolliphor ® EL.

23 disclosed in U.S. Pat. No. 9,050,261 (Symrise).











































































































































































































Preferably, the substantially non-odorous fragrance modulator is selected from the group of materials disclosed in Table 4(b).





TABLE 4(b)



Substantially Non-Odorous Fragrance Modulators










CAS


No.
Chemical or INCI Name
Trade Name
Number
Supplier









1.
C12-14 Sec-Pareth-3
Tergitol ® 15-S-7
68131-40-8
Sigma Aldrich





(UK)

2.
Poly(ethylene glycol-ran-
PPG-7-Buteth-10
9038-95-3
Sigma Aldrich


propylene glycol) monobutyl


(UK)


ether




3.
PPG-4-Ceteth-10
Nikkol PBC-33
37311-01-6
Chemical





Navi

4.
Deceth-4
Ethal DA-4
5703-94-6
Ethox





Chemicals,





Inc.

5.
PPG-5-Ceteth-20
AEC PPG-5-Ceteth-20
9087-53-0
A & E





Connock





(Perfumery &





Cosmetics)





Ltd.

6.
C14-15 Pareth-7
Neodol 45-7 alcohol
68951-67-7
Shell



ethoxylate

Chemical





Company

7.
Linear alcohol (C12-15) Pareth-
Bio-soft N25-7
68131-39-5
Stephan


3ethoxylate, POE-7


Company

8.
Linear alcohol (C12-13) Pareth-
Bio-soft N23-6.5
66455-14-9
(USA)


3ethoxylated, POE-6.5)




9.
Polyethylene glycol 1100
Cremophor ® A 25
68439-49-6
Sigma Aldrich


mono(hexadecyl/octadecyl)


(UK)


ether




10.
Linear alcohol (C9-11)
Bio-soft N91-8
68439-46-3
Stephan


ethoxylated POE-8 Pareth-3


Company





(USA)

11.
Coceth-10 or
Genapol ® C-100
61791-13-7
Sigma Aldrich


Polyoxyethylene (10) dodecyl


(UK)


ether




12.
Alcohols, C12-14, ethoxylated
Rhodasurf ® LA 30
68439-50-9
Solvay





Solutions





Italia S.p.A.

13.
Poly(ethylene glycol) methyl
Poly(ethylene glycol)
9004-74-4
Sigma Aldrich


ether
methyl ether

(UK)

14.
C10-16 Pareth-1
Neodol ® PC 110
68002-97-1
Shell





Chemical





Company

15.
PPG-11 Stearyl Ether
Arlamol ™ PS11E
25231-21-4
Croda (UK)

16.
Steareth-100
Brij ® S100
9005-00-9
Sigma Aldrich





(UK)

17.
Polyethylene glycol hexadecyl
Brij ® C-58
9004-95-9
Sigma Aldrich


ether


(UK)

18.
Pluronic ® F-127
Pluronic ® F-127
9003-11-6
Sigma Aldrich





(UK)

19.
Linear Alcohol (C11)
Bio-soft N1-5
34398-01-1
Stepan


Ethoxylate, POE-5


Canada Inc.

20.
Laureth-10
Intrasol FA 12/18/10
6540-99-4
Evonik





Industries AG

21.
Decaethylene glycol
Polyoxyethylene (10)
9002-92-0
Sigma Aldrich


mono-dodecyl ether
lauryl ether

(UK)

22.
Ethylene glycol monomethyl
2-Methoxyethanol
109-86-4
Sigma Aldrich


ether


(UK)

23.
Myreth-4
Homulgator 920 G
27306-79-2
Grau





Aromatics





GmbH &





Company KG

24.
Oleth-16
Pegnol O-16A
25190-05-0
Toho


Alkoxylated Alcohols


Chemical





Industry Co.,





Ltd.

25.
Isosteareth-5
Emalex 1805
52292-17-8
Nihon





Emulsion





Company,





Ltd.

26.
PPG-10 Cetyl Ether
Arlamol ™ PC10
9035-85-2
Croda (UK)

27.
Polyoxy(ethylene glycol) (18)
Poly(ethylene glycol)
24938-91-8
Sigma-


tridecyl ether
(18) tridecyl ether

Aldrich (UK)

28.
Poly(oxy-1,2-ethanediyl), a-
ALFONIC ® 10-8
26183-52-8
Sasol


decyl-w-hydroxy-
Ethoxylate

Chemicals





(USA) LLC

29.
Laureth-1
Mackam ™ 2LSF
4536-30-5
Rhodia (DE)

30.
PEG-5 Hydrogenated Tallow
Ethox HTAM-5
61791-26-2
Ethox


Amine


Chemicals,





Inc.

31.
PEG-15 Oleamine
Nikkol TAMNO-15
26635-93-8
Nikko





Chemicals





Co., Ltd.

32.
Polyoxyethylene (20) oleyl ether
Brij ® O20-SS
9004-98-2
Sigma Aldrich





(UK)

33.
Cetoleth-10
Brij ® CO10
8065-81-4
Croda, Inc.

34.
Talloweth-7
Emulmin 70
61791-28-4
Sanyo





Chemical





Industries Ltd.

35.
Isobutoxypropanol
Isobutoxypropanol
34150-35-1
MolPort


Alcohols




36.
Isobutoxypropanol
Isobutoxypropanol
23436-19-3
AKos


Alcohols


Consulting &





Solutions

37.
Diethylene Glycol
Twincide EDG
111-46-6
Roda

38.
Methoxyethanol
Hisolve MC
109-86-4
Toho





Chemical





Industry Co.,





Ltd.

39.
Ethoxyethanol
2-Ethoxyethanol
110-80-5
Sigma-


Alcohols


Aldrich (UK)

40.
Methoxyisopropanol
Dowanol ™ PM
107-98-2
The Dow


Alcohols


Chemical





Company

41.
Methoxyethanol
Hisolve MC
32718-54-0
Toho





Chemical





Industry Co.,





Ltd.

42.
Methylal
Dimethoxymethane
109-87-5
Sigma-


Ethers


Aldrich (UK)

43.
3-Methoxybutanol
Methoxybutanol
2517-43-3
Hans





Schwarzkopf





GmbH/Co.





KG

44.
Butoxyethanol
Butyl OXITOL
111-76-2
Shell





Chemical





Company

45.
Propylene Glycol n-Butyl Ether
Dowanol ™ PnB
5131-66-8/29387-86-8
The Dow





Chemical





Company

46.
Propylene Glycol Butyl Ether
Propylene Glycol Butyl
15821-83-7
Sigma Aldrich



Ether

(UK)

47.
2-(2-butoxyethoxy)ethanol
Diethylene glycol butyl
112-34-5
Sigma Aldrich



ether

(UK)

48.
Deceth-4 Phosphate
Crodafos ™ D4A
52019-36-0
Croda, Inc.

49.
2-(Hexadecyloxy)ethanol
Ethylene glycol
2136-71-2
Sigma-



monohexadecyl ether

Aldrich (UK)

50.
Poly(propylene glycol)
Poly(propylene glycol)
9003-13-8
Sigma-


monobutyl ether
monobutyl ether

Aldrich (UK)

51.
Propylene Glycol Propyl Ether
Dowanol ™ PnP
30136-13-1
The Dow





Chemical





Company

52.
Propylene Glycol n-Butyl Ether
Dowanol ™ PnB
29387-86-8/5131-66-8
The Dow





Chemical





Company

53.
Dipropylene glycol monomethyl
Di(propylene glycol)
34590-94-8
Sigma Aldrich


ether
methyl ether, mixture of

(UK)



isomers



54.
Dipropylene Glycol Dimethyl
Proglyde ™ DMM
111109-77-4
The Dow


Ether


Chemical





Company

55.
PPG-2 Methyl Ether
Dowanol ™ DPM
13429-07-7
The Dow





Chemical





Company

56.
Methoxydiglycol
OriStar DEGME
111-77-3
Orient Stars


Ethers


LLC

57.
Diethylene glycol ethyl ether
Di(ethylene glycol) ethyl
111-90-0
Sigma Aldrich



ether

(UK)

58.
Dimethoxydiglycol
Dimethyldiglycol
111-96-6
H&V


Ethers


Chemicals

59.
PPG-3 Methyl Ether
Dowanol ™ TPM
37286-64-9
The Dow





Chemical





Company

60.
Methyl Morpholine Oxide
224286 ALDRICH
7529-22-8
Sigma-


Amine Oxides
4-Methylmorpholine N-

Aldrich (UK)



oxide



61.
Oleth-3
Brij ® O3
5274-66-8
Croda Europe,





Ltd.

62.
Tri(propylene glycol) n-butyl
Dowanol ™ TPnB
55934-93-5
Sigma-


ether


Aldrich (UK)

63.
Tripropylene Glycol
Tripropylene Glycol
24800-44-0
Sigma-





Aldrich (UK)

64.
PPG-3 Methyl Ether
Dowanol ™ TPM
25498-49-1
The Dow


Alkoxylated Alcohols


Chemical





Company

65.
Triethylene glycol
Triglycol
112-27-6
Sigma Aldrich





(UK)

66.
PEG-3 Methyl Ether
Hymol ™
112-35-6
Toho





Chemical





Industry Co.,





Ltd.

67.
Laureth-3
AEC Laureth-3
3055-94-5
A&E





Connock





(Perfumery &





Cosmetics)





Ltd.

68.
Ethylhexylglycerin
AG-G-75008
70445-33-9
Angene





Chemical

69.
Tetra(ethylene glycol)
Tetraethylene glycol
112-60-7
Sigma Aldrich





(UK)

70.
Steareth-3
Isoxal 5
4439-32-1
Vevy Europe





SpA

71.
Ceteth-3
Emalex 103
4484-59-7
Nihon





Emulsion





Company,





Ltd.

72.
Myreth-3
Isoxal 5
26826-30-2
Vevy Europe





SpA

73.
Trideceth-3
Alfonic ® TDA-3
—
Sasol North



Ethoxylate

America, Inc.

74.
Ceteth-2
Brij ® C2
5274-61-3
Croda Europe,





Ltd.

75.
Oleth-2
Brij ® O2
5274-65-7
Croda, Inc.

76.
Steareth-2
Brij ® S2
16057-43-5
Croda, Inc.

77.
Cetoleth-10
Brij ® CO10
8065-81-4
Croda, Inc.

78.
Trimethyl Pentanol
Trimethyl Pentanol
68959-25-1
Angene


Hydroxyethyl Ether
Hydroxyethyl Ether

Chemical


Alcohols




79.
Steareth-10 Allyl Ether
Salcare ® SC80
109292-17-3
BASF

80.
TEA-Lauryl Ether
material ID- AG-J-99109
1733-93-3
Angene





Chemical

81.
Polyglyceryl-2 Oleyl Ether
Chimexane NB
71032-90-1
Chimex

82.
Batyl Alcohol
B402 ALDRICH
544-62-7
Sigma-





Aldrich (UK)

83.
Octaethylene Glycol
15879 ALDRICH
5117-19-1
Sigma-





Aldrich (UK)

84.
Triglycerol diisostearate
Cithrol ™
66082-42-6
Croda (UK)

85.
Diglycerin
Diglycerin 801
59113-36-9
Sakamoto





Yakuhin





Kogyo Co.,





Ltd.

86.
Polyglycerin #310
Polyglycerin #310
25618-55-7
Sakamoto





Yakuhin





Kogyo Co.,





Ltd.

87.
Distearyl Ether
Cosmacol ® SE
6297-03-6
Sasol





Germany





GmbH

88.
Caprylyl Glyceryl Ether
Caprylyl Glyceryl Ether
10438-94-5
AKos





Consulting &





Solutions

89.
Chimyl Alcohol
Chimyl Alcohol
506-03-6
Nikko





Chemicals





Co., Ltd.

90.
Dipentaerythrityl
Liponate ® DPC-6
68130-24-5
Lipo


Hexacaprylate/Hexacaprate


Chemicals,





Inc.

91.
Morpholine
394467 ALDRICH
110-91-8
Sigma-





Aldrich (UK)

92.
Dimethyl Oxazolidine
OXABAN ™ -A
51200-87-4
The Dow





Chemical





Company

93.
Ethyl Hydroxymethyl Oleyl
4-Oxazolemethanol
68140-98-7
Angene


Oxazoline


Chemical

94.
Methyl Hydroxymethyl Oleyl
Adeka Nol GE-RF
14408-42-5
Adeka


Oxazoline


Corporation

95.
Pramoxine HCl
OriStar PMHCL
637-58-1
Orient Stars





LLC

96.
Allantoin Ascorbate
Allantoin Ascorbate
57448-83-6
ABI Chem

97.
Stearamidopropyl Morpholine
Mackalene ™ 326
55852-14-7
Rhodia Inc.


Lactate




98.
Dioxolane
Elcotal DX
646-06-0
Lambiotte &





CIE S.A.

99.
Glycerol Formal
Glycerol Formal
5464-28-8
Sigma Aldrich





(UK)

100.
Stearamidopropyl Morpholine
Mackine 321
55852-13-6
Rhodia Inc.

101.
2,4,6-
Poly(melamine-co-
68002-20-0
Sigma-


Tris[bis(methoxymethyl)amino]-
formaldehyde)

Aldrich (UK)


1,3,5-triazine
methylated



102.
Poloxamine 1307
Pluracare ® 1307
11111-34-5
BASF

103.
Nonoxynol-8
Igepal ® CO-610
27177-05-5
Rhodia Inc.

104.
Nonoxynol-10
Igepal ® CO-710
27177-08-8
Rhodia Inc.

105.
Octoxynol-10
Nikkol OP-10
2315-66-4
Nikko





Chemicals





Co., Ltd.

106.
Nonoxynol-9
Igepal ® CO-630
68987-90-6
Rhodia Inc.

107.
Nonoxynol-9 Iodine
Nonoxynol-9 iodine
94349-40-3
Angene





Chemical

108.
Octylphenoxy
Igepal ® CA-630
68987-90-6
Rhodia Inc.


poly(ethyleneoxy)ethanol,





branched




109.
Sodium Octoxynol-2 Ethane
Triton ™ X-200
55837-16-6
The Dow


Sulfonate


Chemical





Company

110.
Benzylhemiformal
Preventol D2
14548-60-8
Lanxess





Corporation

111.
Nonoxynol-2
Igepal ® CO-210
27176-93-8
Rhodia Inc.

112.
Octoxynol-3
Igepal ® CA-420
2315-62-0
The Dow





Chemical





Company

113.
Nonoxynol-3
Marlophen NP 3
27176-95-0
Sasol





Germany





GmbH

114.
Alkoxylated Alcohols
Alkasurf NP-4
7311-27-5
Rhodia Inc.

115.
Nonoxynol-3
Triethylene Glycol
51437-95-7
Santa Cruz



Mono(p-nonylphenyl)

Biotechnology



Ether



116.
Nonoxynol-7
Lowenol 2689
27177-03-3
Jos. H.





Lowenstein &





Sons, Inc.

117.
Nonoxynol-6
Igepal ® CO-530
27177-01-1
Rhodia Inc.

118.
Nonoxynol-5
Igepal ® CO-520
20636-48-0
Rhodia Inc.

119.
Nonoxynol-5
Igepal ® CO-520
26264-02-8
Rhodia Inc.

120.
Nonoxynol-4
Alkasurf NP-4
27176-97-2
Rhodia Inc.

121.
Polyglyceryl-10 Trioleate
Nikkol Decaglyn 3-OV
102051-00-3
Nikko





Chemicals





Co., Ltd.

122.
Polyglyceryl-10 Dioleate
Nikkol Decaglyn 2-O
33940-99-7
Nikko





Chemicals





Co., Ltd.

123.
Polyglyceryl-10 Tetraoleate
Caprol 10G40
34424-98-1
Abitec





Corporation

124.
Polyglyceryl-10 Stearate
Nikkol Decaglyn 1-SV
79777-30-3
Nikko



EX

Chemicals





Co., Ltd.

125.
Polyglyceryl-10 Oleate
S-Face O-1001 P
79665-93-3
Sakamoto





Yakuhin





Kogyo Co.,





Ltd.

126.
Polyglyceryl-10 Myristate
Nikkol Decaglyn 1-MV
87390-32-7
Nikko



EX

Chemicals





Co., Ltd.

127.
Dermofeel ® G 10 L
Dermofeel ® G 10 L
34406-66-1
Dr.





Straetmans

128.
Polyglyceryl-6 Laurate
NIKKOL Hexaglyn 1-L
51033-38-6
Chemical





Navi

129.
Polyglyceryl-6 Isostearate
S-Face IS-601 P
126928-07-2
Sakamoto





Yakuhin





Kogyo Co.,





Ltd.

130.
Choleth-10
Emalex CS-10
27321-96-6
Nihon





Emulsion





Company,





Ltd.

131.
Steareth-10 Allyl
Salcare ® SC80
109292-17-3
BASF


Ether/Acrylates Copolymer




132.
Polyvinyl Stearyl Ether
Giovarez ® 1800
9003-96-7
Phoenix





Chemical, Inc.

133.
Dicetyl Ether
Cosmacol Ether 16
—
Sasol





Germany





GmbH

134.
PPG-23-Steareth-34
Unisafe 34S-23
9038-43-1
Pola Chemical





Industries,





Inc.

135.
Stearoxypropyl Dimethylamine
Farmin DM E-80
17517-01-0
Kao Corp.

136.
Distearyl Ether
Cosmacol SE
6297-03-6
Sasol





Germany





GmbH

137.
Polyquaternium-10
AEC Polyquaternium-10
55353-19-0
A & E





Connock





(Perfumery &





Cosmetics)





Ltd.

138.
Octyl ether
Dioctyl ether
629-82-3
Sigma Adlrich





(UK)

139.
Ethyl Ether
Diethyl Ether
60-29-7
EMD





Chemicals

140.
Methyl Hexyl Ether
methyl hexyl ether
4747-07-3
TCI


Ethers


AMERICA

141.
Ceteth-12
Emalex 112
94159-75-8
Nihon





Emulsion





Company,





Ltd.

142.
Ceteth-10 or cetyl alcohol POE-
Jeecol CA-10
14529-40-9
Jeen


10


International

143.
Steareth-10
Jeecol SA-10
13149-86-5
Jeen





International

144.
Nonaethylene glycol
Nonaethylene glycol
3055-99-0
Sigma Aldrich


monododecyl ether
monododecyl ether

(UK)

145.
Oleth-10
Brij ® O10
71976-00-6
Croda, Inc.

146.
Oleth-10
Brij ® O10
24871-34-9
Croda, Inc.

147.
PEG-12
Carbowax ™ PEG 600
6790-09-6
The Dow





Chemical





Company

148.
PEG-9
Sabopeg 400
3386-18-3
Sabo s.p.a.

149.
PEG-10
DECAETHYLENE
5579-66-8
MolPort



GLYCOL



150.
PEG-6
Carbowax ™ PEG 300
2615-15-8
The Dow





Chemical





Company

151.
Glycerol propoxylate
Glycerol propoxylate
25791-96-2
Sigma Aldrich





(UK)

152.
Glycerol ethoxylate
Glycerol ethoxylate
31694-55-0
Sigma Aldrich





(UK)

153.
Laureth-8
AEC Laureth-8
3055-98-9
A & E





Connock





(Perfumery &





Cosmetics)





Ltd.

154.
Oleth-8
Emalex 508
27040-03-5
Nihon





Emulsion





Company,





Ltd.

155.
Laureth-7
Alfonic 1216CO-7
3055-97-8
Sasol North



Ethoxylate

America, Inc.

156.
Steareth-7
Polyoxyethylene (7)
66146-84-7
Sigma Aldrich



stearyl ether



157.
Deceth-6
Alfonic 1012-6.0
5168-89-8
Sasol North



Ethoxylate

America, Inc.

158.
Steareth-6
Emalex 606
2420-29-3
Nihon





Emulsion





Company,





Ltd.

159.
Hexaethylene glycol
Hexaethylene glycol
3055-96-7
Sigma-


monododecyl ether
monododecyl ether

Aldrich (UK)

160.
Hexaethylene glycol
Hexaethylene glycol
5168-91-2
Sigma-


monohexadecyl ether
monohexadecyl ether

Aldrich (UK)

161.
Beheneth-5
Nikkol BB-5
136207-49-3
Nikko





Chemicals





Co., Ltd.

162.
Myreth-5
Isoxal 12
92669-01-7
Vevy Europe





SpA

163.
Steareth-5
Jeecol SA-5
71093-13-5
Jeen





International





Corporation

164.
Ceteth-5
Emalex 105
4478-97-1
Nihon





Emulsion





Company,





Ltd.

165.
Oleth-5
Brij ® O5
5353-27-5
Croda, Inc.

166.
Laureth-5
Safol ® 23E5 Ethoxylate
3055-95-6
Sasol North





America, Inc.

167.
Steareth-4
Jeecol SA-4
59970-10-4
Jeen





International





Corporation

168.
Laureth-4
Brij ® L4
5274-68-0
Croda, Inc.

169.
Myreth-4
Homulgator 920 G
39034-24-7
Grau





Aromatics





GmbH &





Company KG

170.
Ceteth-4
Procol CA-4
5274-63-5
Protameen





Chemicals

171.
Oleth-4
Chemal OA-4
5353-26-4
Chemax, Inc.

172.
Oleth-4
Chemal OA-4
103622-85-1
Chemax, Inc.

173.
Polyimide-1
Aquaflex ™ XL-30
497926-97-3
Chemwill

174.
Polymethoxy Bicyclic
Caswell No. 494CA
56709-13-8
Angene


Oxazolidine


Chemical

175.
Hydroxymethyl
Zoldine ™ ZT
6542-37-6
Angus


Dioxoazabicyclooctane


Chemical





Company

176.
Dihydro-7a-ethyloxazolo[3,4-
5-Ethyl-1-aza-3,7-
7747-35-5
Sigma Aldrich


c]oxazole
dioxabicyclo[3.3.0]octane

(UK)

177.
Dibenzylidene Sorbitol
Disorbene ®
32647-67-9
Roquette





America, Inc.

178.
Dimethyldibenzylidene Sorbitol
Millad ® 3988
135861-56-2
Milliken





Chemicals

179.
Laureth-2
Alfonic 1216CO-2
3055-93-4
Sasol North



Ethoxylate

America, Inc.

180.
2-(2-Butoxyethoxy)ethyl (6-
Piperonyl Butoxide
51-03-6
Sigma-


propylpiperonyl) ether


Aldrich (UK)

181.
Menthone Glycerin Acetal
Frescolat ® MGA
63187-91-7
Symrise

182.
Propylene Glycol Caprylate
Mackaderm PGC
68332-79-6
Rhodia Inc.

183.
Diethoxynonadiene
SBB016951
67674-36-6
Ambinter

184.
Menthoxypropanediol
Coolact ® 10
87061-04-9
Takasago


Alcohols


International





Corporation

185.
2-Diphenylmethoxy-N,N-
Diphenhydramine HCl
147-24-0
Sigma-


dimethylethylamine


Aldrich (UK)


hydrochloride




186.
3-((2-ethylhexyl)oxy)propane-
—
70445-33-9
—


1,2-diol




187.
3-((2-propylheptyl)oxy)propane-
—
—
—


1,2-diol




188.
1-amino-3-((2-
—
99509-00-9
—


ethylhexyl)oxy)propan-2-ol




189.
1-(1-Methyl-2-propoxyethoxy)-
Di(propylene glycol)
29911-27-1
Sigma Aldrich


2-propanol
propyl ether

(UK)



















































































































































































































































































































































































































































































The compounds, as described above in Tables 4(a) and 4(b), act as a substantially non-odorous fragrance modulator of the perceived fidelity and/or longevity of the fragrance profile of the composition of the present invention. For example, the substantially non-odorous fragrance modulators, with a fragrance component having a diamond construction, act to prolong the duration during which the fragrance profile, preferably the characters attributable from the moderate and high volatile fragrance materials, can be perceived as compared to a control composition in the absence of the modulators or having the classical fragrance pyramid three-tiered structure. As another example, the substantially non-odorous fragrance modulators, with a fragrance component having a diamond construction, can improve the fidelity of the fragrance profile, preferably the characters attributable from the moderate and high volatile fragrance materials, such that it remains significantly the same from initial impression to the end as compared to a control composition in the absence of the modulators or having the classical fragrance pyramid three-tiered structure. While not wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulators associate to the fragrance materials and retard evaporation.
Test Methods
The following assays set forth must be used in order that the invention described and claimed herein may be more fully understood.
Test Method 1: Determining Vapor Pressure
In order to determine the vapor pressure for the fragrance materials, go to the website https:/scifinder.cas.org/scifinder/view/scifinder/scifinderExplore.jsf and follow these steps to acquire the vapor pressure.
1. Input the CAS registry number for the particular fragrance material.
2. Select the vapor pressure from the search results.
3. Record the vapor pressure (given in Torr at 25° C.).
SciFinder uses Advanced Chemistry Development (ACD/Labs) Software Version 11.02. (© 1994-2013). If the CAS number for the particular fragrance material is unknown or does not exist, you can utilize the ACD/Labs reference program to directly determine the vapor pressure. Vapor Pressure is expressed in 1 Torr, which is equal to 0.133 kilopascal (kPa).
Test Method 2: Olfactory Tests
In order to show the effect of the substantially non-odorous fragrance modulators and fragrance component having a diamond construction on the perception of fragrance profile in a composition of the present invention, test compositions are made, as described in the Example section, and given to panelists to evaluate.
At the testing facility, 50 μL samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32° C. to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry. Typically, around 6-10 panellists are used to evaluate a given product and its control.
(a) Fragrance Intensity:
The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below.





TABLE 4



Odour Intensity Scale




Score
Fragrance Intensity



0
None

1
Very Weak

2
Weak

3
Moderate

4
Strong

5
Very Strong


























(b) Fragrance Character:
The panelists are asked to assess the fragrance character in one of 2 ways:
i) a score on a scale of 0 to 3 for the dominance of particular characters that are relevant to that particular fragrance, e.g.: fresh, green, watery, floral, rose, muguet, fruity, apple, berry, citrus, creamy, woody, balsamic, amber, musk just to name a few, according to the odour grading scale set out in Table 5(i) herein below; ii) a score on a scale of 1 to 5 for changes in the perceived fragrance profile change for the test compositions versus the controls according to the odour grading scale set out in Table 5(ii) herein below.






TABLE 5(i)



Character Dominance Odour Grading Scale




Score
Fragrance Character Dominance



0
Not noticeable

1
Slight presence of the character

2
Moderate presence of the character

3
Dominance of the character





























TABLE 5(ii)



Character Difference Odour Grading Scale




Score
Fragrance Profile Change



1
Frargrance profile is unchanged, i.e., no difference between the


sample vs. the control.

2
Slight fragrance profile change when compared directly with the


control.

3
Moderate fragrance profile but similar character to the control.

4
Large difference in fragrance profile from the control.

5
Total difference in the fragrance profile from the control.



























The results of the panelists are averaged and then analysed using Analysis of Variance methods. The model treats the subject as a random effect and looks at the impact of product, time and the interaction between product and time. From the analysis the least square means for the product and time interaction are obtained. These means (as well as their confidence intervals) are then plotted to enable comparisons between products at each time point. It should be noted that the confidence levels plotted are intended as a guide, and not as a statistical comparison, as they do not take into account that multiple testing has been performed. As well as a graphical assessment, statistical comparisons between the two products at each of the time points are performed with a Sidak correction for multiple comparisons. The p-values for the product differences are obtained, with p-values <0.05 indicating a statistical difference between the two products at 5% significance (or 95% confidence).
Test Method 3: Analytical Evaporation Tests
The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance modulator on the evaporation rate of one or more fragrance materials (e.g., 10 PRMs) formulated in a composition. The evaporation response of the fragrance materials to the modulator, as a function of time, is measured through the use of gas chromatography (“GC”).
1. A test composition may comprise a substantially non-odorous fragrance modulator (any one of the modulators as disclosed in Tables 4(a) and 4(b)) with either: (i) a fragrance material (any one of the moderate volatile fragrance materials as disclosed in Table 2 and high volatile fragrance materials as disclosed in Table 3), or (ii) a blend of fragrance materials from Tables 2 and 3 (as disclosed as Fragrance Example 6 in Table 11). The test compositions also contain high purity ethanol, such as Hayman 100% EP/BP grade, and deionized water. Samples test compositions are provided in Tables 19(a)-19(b). All of the ingredients are admixed until evenly distributed in the test compositions. 2. A control composition to the test composition described in 1 above, without the substantially non-odorous fragrance modulator is made in a similar manner to Step 1, except that the missing substantially non-odorous modulator is replaced by deionized water. Sample control compositions are provided in Tables 19(a)-19(b). 3. An internal standard is needed to correct for variations of the amount of composition dispensed in the evaporation test as well as loss during the GC analysis. The internal standard has a vapor pressure of less than 0.001 Torr (0.000133 kPa) at 25° C. and is soluble in the composition and fragrance material. A suitable non-limiting example of an internal standard is triethyl citrate. The internal standard and fragrance material are admixed until evenly distributed at a level of 90 to 95 parts by weight of fragrance material and the required amount of internal standard to reach 100 parts. This mixture is then use to prepare the sample compositions in Step 1 and 2. Alternatively, the internal standard and test or control composition are admixed until evenly distributed at a level of 99 to 99.75 parts by weight of composition and the required amount of internal standard to reach 100 parts. This resultant solution is used in subsequent steps. 4. A hotplate is set to a temperature of 32° C. An aluminum container, such as TA Instruments T-Zero™ pan, is placed on the hotplate. 20 μL of the test or control composition is introduced in the aluminum container using a micropipette. Alternatively, the aluminum container may be filled with the test or control composition to its full capacity. The time at which this takes place is determined to be time zero (i.e., T=0). Multiple aluminum containers are prepared and left at the set temperature for pre-determined periods of time, such as for example 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs, 8 hrs and up to 12 hrs. 5. The aluminum container is removed from the hotplate at the end of the pre-determined time period and transferred by being inserted into a 4 mL glass vial already containing at least 2 mL of highly volatile solvent, such as high purity ethanol or hexane. 6. The glass vial is mixed using a Heidolph multi REAX shaker, or equivalent, for 5 to 10 mins to extract the fragrance materials into the solvent phase. 1.5 mL of the resultant solution is transferred to a 2 mL GC vial. 7. The GC vial is analysed on an Agilent GC system 6890 equipped with an autosampler, or equivalent. A GC column such as a DB-5MS, Rxi-5 SilMS model or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 μm is used. The GC parameters are set to the values indicated as follows:






TABLE 5(iii)



GC Parameters









Injector temperature:
270°
C.




Initial gas velocity:
25 to 40 cm/sec (for Helium as the carrier gas)





Initial oven temperature:
50°
C.

Temperature ramp:
8°
C./min

Final oven temperature:
310°
C.

































Gas chromatography with flame ionization detection (“FID”) or with mass spectrometry (“MS”) can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material and internal standard being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and quantification of the analytes of interest.
8. The peak area of the fragrance material and internal standard are recorded. The peak area ratio of the fragrance material and the internal standard is calculated at each time point for each sample composition. The % of non-evaporated fragrance material remaining from T=0 is calculated at each time point for each sample composition. The % fragrance material remaining in each composition is plotted to give an evaporation profile over time. This is done for both the test and control compositions. Significance is determined by comparison of the evaporation profile for the same fragrance material or same fragrance mixture in the test and control compositions.




Test Method 4: Analytical Headspace Tests
The following test is carried out to demonstrate the character retention over time of a fragrance composition of the present invention vs. a control. It is necessary for the test and control samples to be run at approximately the same time to ensure that ambient conditions are the same. The test measures the presence of one or more fragrance materials in the headspace formed in a sealed vial by the test composition, after set evaporation times. The fragrance profile in the headspace is measured at specific time points through the use of headspace (“HS”) gas chromatography (“GC”).
1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich “Stuart™ melting point tube” product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 μL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T=initial (i.e., T=10 mins). 5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed. 6. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 μm, 1 cm length) is required. A GC column such as a DB-5MS, ZB-5MSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 μm is used. 7. The SPME HS parameters are set to the values indicated as follows:






TABLE 5(iv)



SPME Parameters











Incubation chamber temperature:
40°
C.


Incubation time:
20
mins


Agitation of sample
250
RPM


Extraction time
5
mins


Desorption time
2
mins



























8. The GC parameters are set to the values indicated as follows:









TABLE 5(v)



GC Parameters









Injector temperature:
270°
C.




Initial gas velocity:
20 to 40 cm/sec (for Helium as the carrier gas)

Initial oven temperature:
45° C. with 2 mins Hold Time





Temperature ramp 1:
30°
C./min

Temperature 1:
80°
C.

Temperature ramp 2:
8°
C./min

Final temperature:
300°
C.



































Gas chromatography with flame ionization detection (“FID”) or with mass spectrometry (“MS”) can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and identification of the analytes of interest.
9. A qualitative assessment of the chromatograms obtained is performed by comparing the peak height of the fragrance materials and overall chromatogram at time T=10 mins to other time points. A dotted line is drawn around an estimated retention time where fragrance materials with a vapour pressure of 0.001 Torr or less (0.000133 kPa or less) elute during the analysis. The difference between the peaks present at each measured time point for the test and control compositions provides evidence of the retention of the character of the fragrance over time.
10. This test set-up is designed to enable the collection of the headspace in a manner that does not saturate the SPME fiber. If the fiber is saturated it does not provide an accurate analysis of the headspace composition. Therefore the quantity of liquid and the evaporation surface area are very different from those in the olfactive evaluation of the same samples. For this reason it is not possible to compare directly the evaporation time frames used in the 2 experiments. It is expected that the evaporation profile is much faster in this headspace experiments compared to the olfactive evaluations.




EXAMPLES
The following examples are provided to further illustrate the present invention and are not to be construed as limitations of the present invention, as many variations of the present invention are possible without departing from its spirit or scope.
Example 1—Fragrance Oils
Fragrance examples 1, 2, 3, 4b and 5b are provided below in Tables 6, 7, 8, 9 and 10, respectively, as non-limiting examples of formulations of fragrance materials intended to form the fragrance component of the compositions of the present invention. The exemplary formulations of the fragrance materials span the range from “simple accords” (less than 10 fragrance materials) to “complex fragrances” (greater than 30 fragrance materials). Typically, full bodied fragrance compositions do not comprise less than about 30 fragrance materials.
Fragrance examples 4a and 5a provided in Table 9 and 10, respectively, below are examples of traditional formulations of fragrance materials that fall outside the scope of the present invention.
Fragrance example 6 provided in Table 11 below as an example of a formulation of volatile fragrance materials.
Fragrance examples 7 and 8 are provided in Tables 12 and 13 below as examples of a formulation of fragrance materials intended to form the fragrance component that fall outside the scope of the present invention.
Fragrance examples 9 to 16 are provided in Tables 14 and 15 below as examples of formulations of fragrance materials containing higher than 30 wt % of the low volatile fragrance materials.
Fragrance examples 17 and 18 are provided in Tables 16 and 17 below as comparative samples of formulations of fragrance materials intended to form the fragrance component.
The following fragrance formulations are made by mixing the listed ingredients in the listed proportions (wt %) at room temperature, wherein the wt % is relative to the total weight of the fragrance component.





TABLE 6



Fragrance Example 1 (Fresh Floral Accord - 10

wt % of Low Volatile Fragrance Materials)








Vapor Pressure
Parts

Ingredients
CAS Number
(Torr at 25° C.)
(wt %)








Benzyl acetate
140-11-4
0.1640
10.8

Linalool
78-70-6
0.0905
9.8

Phenethyl alcohol
60-12-8
0.0741
15.7

Indole
120-72-9
0.0298
1.0

α-Terpineol
98-55-5
0.0283
2.9

Geranyl acetate
105-87-3
0.0256
4.9

Cymal
103-95-7
0.00881
5.9

Hydroxycitronellal
107-75-5
0.00318
22.4

Majantol
103694-68-4
0.00224
16.6

Hexyl cinnamic
101-86-0
0.000697
10.0

aldehyde







Total
100.00













































TABLE 7



Fragrance Example 2 (Fresh Male Accord - 13.51

wt % of Low Volatile Fragrance Materials)








Vapor Pressure
Parts

Ingredients
CAS Number
(Torr at 25° C.)
(wt %)








d-Limonene
5989-27-5
1.540000
10.0

Dihydromyrcenol
18479-58-8
0.166000
10.0

Boisiris
68845-00-1
0.013500
6.5

Canthoxal
5462-06-6
0.010200
8.0

Helional
1205-17-0
0.002700
10.0

Kephalis
36306-87-3
0.002690
20.0

Majantol
103694-68-4
0.002240
15.5

Javanol ®
198404-98-7
0.000902
5.0

Galaxolide ® *
1222-05-5
0.000414
7.5

Isopropyl
110-27-0
—
7.5

Myristate







Total
100.00



* Supplied at 50% in Isopropyl myristate.












































TABLE 8



Fragrance Example 3 (Sweet Dream 18 Fragrance -

11.15 wt % of Low Volatile Fragrance Materials)








Vapor Pressure
Parts

Ingredients
CAS Number
(Torr at 25° C.)
(wt %)








Prenyl acetate
1191-16-8
3.99000000
0.100

Manzanate
39255-32-8
2.91000000
0.200

Hexyl acetate
142-92-7
1.39000000
0.700

cis-3-Hexenyl
3681-71-8
1.22000000
0.200

acetate




Benzaldehyde
100-52-7
0.97400000
0.200

Liffarome
67633-96-9
0.72100000
0.150

Hexyl isobutyrate
2349-07-7
0.41300000
0.055

Dihydromyrcenol
18479-58-8
0.16600000
2.500

Benzyl acetate
140-11-4
0.16400000
0.700

Linalyl acetate
115-95-7
0.11600000
2.500

Verdox
88-41-5
0.10300000
4.000

Phenethyl alcohol
60-12-8
0.07410000
8.000

Rossitol
215231-33-7
0.02990000
1.500

alpha-Terpineol
98-55-5
0.02830000
1.500

Geranyl acetate
105-87-3
0.02560000
1.500

Rhodinol
141-25-3
0.01970000
0.700

Givescone
57934-97-1
0.01710000
0.700

Methyl anthranilate
134-20-3
0.01580000
0.050

Ysamber K
154171-77-4
0.01470000
1.000

alpha-Ionone
127-41-3
0.01440000
3.000

Citronellyl acetate
150-84-5
0.01370000
0.500

cis-3-hexenyl-cis-3-
61444-38-0
0.01220000
0.200

hexenoate




Cinnamic alcohol
104-54-1
0.01170000
0.100

delta-damascone
57378-68-4
0.01020000
0.200

Citronellyloxyacetaldehyde
7492-67-3
0.00967000
0.100

Cymal
103-95-7
0.00881000
0.500

Floralozone
67634-15-5
0.00808000
0.100

Ethylmethylphenylglycidate
77-83-8
0.00571000
0.200

Florosa Q
63500-71-0
0.00557000
3.000

Ethyl linalool
10339-55-6
0.00520000
6.400

Pivarose
67662-96-8
0.00484000
2.500

Hydroxycitronellal
107-75-5
0.00318000
7.500

Methyl Ionone
7779-30-8
0.00286000
4.000

gamma-
104-67-6
0.00271000
0.500

Undecalactone




Kephalis
36306-87-3
0.00269000
5.000

Cashmeran
33704-61-9
0.00269000
1.000

Magnolan
27606-09-3
0.00251000
3.000

Majantol
103694-68-4
0.00224000
6.900

Brahmanol
72089-08-8
0.00154000
3.000

Coumarin
91-64-5
0.00130000
0.500

Glycolierral
68901-32-6
0.00121000
0.100

Raspberry ketone
5471-51-2
0.00106000
0.100

Top Mango base 3
—
—
0.500

Cherry base 3
—
—
0.200

Cassis base 3
—
—
0.300

Bergamot Oil 4
—
—
6.000

Prunella base 3
—
—
0.500

Hexyl cinnamic
101-86-0
0.00069700
1.500

aldehyde




Sandalore
65113-99-7
0.00062500
3.000

Dupical
30168-23-1
0.00044100
0.005

Galaxolide ® 1
1222-05-5
0.00041400
1.500

Ebanol
67801-20-1
0.00028100
2.000

Helvetolide
141773-73-1
0.00005790
2.000

Warm Milk base 5
—
—
0.200

Vanilla Absolute 2, 6
—
—
0.100

Isopropyl Myristate
—
—
1.500

Dipropylene Glycol
—
—
6.040



Total
100.00



1 Supplied at 50% in IPM.

2 Supplied at 50% in DiPG.

3 Proprietary bases that contain a mixture of perfume raw materials, judged to be of high volatility for the purposes of calculating % of low volatility PRMs.

4 Natural oils or extracts that contain a mixture of perfume raw materials, judged to be of high volatility for the purposes of calculating % of low volatility PRMs.

5 Proprietary bases that contain a mixture of perfume raw materials, judged to be of low volatility for the purposes of calculating % of low volatility PRMs.

6 Natural oils or extracts that contain a mixture of perfume raw materials, judged to be of low volatility for the purposes of calculating % of low volatility PRMs.
































































































TABLE 9



Fragrance Examples 4a and 4b (“Traditional Floral Magnifica”

Example 4a - 37 wt % of Low Volatile Fragrance Materials;

55 wt % of Moderate Volatile Fragrance Materials; 7 wt %

of High Volatile Fragrance Materials; and “Diamond Floral

Magnifica” Example 4b - 13 wt % of Low Volatile Fragrance

Materials; 80 wt % of Moderate Volatile Fragrance Materials;

7 wt % of High Volatile Fragrance Materials)





Parts (wt %)









Vapor
Exam-




Pressure
ple 4a
Exam-



(Torr at
(Tradi-
ple 4b

Ingredients
CAS Number
25° C.)
tional)
(Diamond)









Beta Gamma
928-96-1
2.126000
0.20
0.20

Hexenol





Cis 3 Hexenyl
3681-71-8
1.219000
0.30
0.30

Acetate





Benzyl Acetate
140-11-4
0.16400000
3.01
3.01

Liffarome
67633-96-9
0.721000
0.20
0.20

Ligustral Or
68039-49-6
0.578000
0.10
0.10

Triplal





Methyl
67674-46-8
0.214000
0.40
0.40

Pamplemousse





d-Limonene
5989-27-5
1.54000000
3.01
3.01

Phenyl

0.368000
0.0002
0.0002

Acetaldehyde 1









Total High Volatile Fragrance Materials
7.2%
7.2%







Alpha Damascone
24720-09-0
0.008300
0.04
0.06

Ethyl 2 4-
3025-30-7
0.009540
0.20
0.20

Decadienoate





Ambronat
6790-58-5
0.009340
2.00
2.01

cis-3-Hexenyl cis-
61444-38-0
0.012200
0.10
0.10

3-Hexenoate





Citronellol
106-22-9
0.032900
4.01
4.01

Cyclemax
7775-00-0
0.018200
0.40
0.40

Cyclo Galbanate
68901-15-5
0.003230
0.10
0.10

Cymal
103-95-7
0.008810
0.90
1.51

Dimethyl Benzyl
10094-34-5
0.001680
0.50
0.50

Carbinyl Butyrate





Ethyl 2,4-
3025-30-7
0.00954000
0.20
0.20

Decadienoate





Ethyl Linalool
10339-55-6
0.005200
7.23
12.04

Florol
63500-71-0
0.005570
6.43
10.71

Gamma
706-14-9
0.008520
0.20
0.20

Decalactone





Geraniol
106-24-1
0.013300
3.01
5.02

Geranyl Acetate
105-87-3
0.009760
2.01
2.01

Helional
1205-17-0
0.002700
2.41
4.01

Heliotropin
120-57-0
0.010400
0.20
0.20

Hivernal
173445-65-3
0.00392000
0.20
0.20

Hydroxy-
107-75-5
0.003180
2.41
4.01

citronellal





Ionone Beta
14901-07-6
0.003080
0.24
0.40

Ionone Gamma
127-51-5
0.002820
1.81
3.01

Methyl





Jasmal
18871-14-2
0.004340
5.02
5.02

Jasmolactone
32764-98-0
0.003550
0.20
0.20

Linalyl
144-39-8
0.026300
1.20
1.20

Propionate





Magnolan 690304
27606-09-3
0.002510
3.01
5.02

Majantol
103694-68-4
0.002240
2.41
4.01

Para Hydroxy
5471-51-2
0.001060
0.20
0.20

Phenyl Butanone





Phenyl Ethyl
60-12-8
0.074100
3.01
5.02

Alcohol





Phenyl Hexanol
55066-48-3
0.006370
3.61
6.02

Undecavertol
81782-77-6
0.010700
2.01
2.01

Vanillin
121-33-5
0.001940
0.10
0.10





Total Moderate Volatile Fragrance Materials
55.4%
79.7%







Ambretone
37609-25-9
0.00003310
1.00
1.00

Ambrettolide
28645-51-4
0.00000139
1.00
1.00

Cis 3-Hexenyl
65405-77-8
0.000246
1.51
0.50

Salicylate





Benzyl salicylate
118-58-1
0.00017500
10.79
1.51

Delta Muscenone
63314-79-4
0.00005650
1.00
1.00

Hedione HC
24851-98-7
0.000710
10.54
3.51

Iso-E Super ®
54464-57-2
0.00053800
10.54
3.51

Polysantol ®
107898-54-4
0.00011700
0.50
0.50





Total Low Volatile Fragrance Materials
36.9%
12.5%

Total
100
100



1 delivered as 1% in DPG.


























































































































TABLE 10



Fragrance Examples 5a and 5b (“Traditional Muguesia Magnifica” Example 5a-37

wt % of Low Volatile Fragrance Materials; 54 wt % of Moderate Volatile Fragrance Materials; 9

wt % of High Volatile Fragrance Materials; and “Diamond Muguesia Magnifica” Example 5b-

13 wt % of Low Volatile Fragrance Materials; 76 wt % of Moderate Volatile Fragrance Materials;

11 wt % of High Volatile Fragrance Materials)









Parts (wt %)









Vapor Pressure
Example 5a
Example 5b

Ingredients
CAS Number
(Torr at 25° C.)
(Traditional)
(Diamond)









Benzyl Acetate
140-11-4
0.304000
5.86
7.32

Benzyl Alcohol
100-51-6
0.158000
0.10
0.10

Beta Gamma
928-96-1
2.126000
0.40
0.40

Hexenol





Cis 3 Hexenyl
3681-71-8
1.219000
0.20
0.20

Acetate





Linalyl Acetate
115-95-7
0.077400
1.00
1.00

Methyl Phenyl
93-92-5
0.203000
0.32
0.40

Carbinyl Acetate





d-Limonene
5989-27-5
1.54000000
1.00
1.00

Phenyl
101-48-4
0.000538
0.20
0.10

Acetaldehyde





Dimethyl Acetal









Total High Volatile Fragrance Materials
9.1%
10.5%







Cis Jasmone
488-10-8
0.020100
0.50
0.50

Cinnamic Alcohol
104-54-1
0.005720
0.20
0.20

Cinnamic
104-55-2
0.02650000
0.06
0.06

Aldehyde





Citronellol
106-22-9
0.032900
4.01
5.01

Citronellyl
150-84-5
0.013700
3.21
4.01

Acetate





Citronellyl
7492-67-3
0.009670
0.10
0.10

Oxyacetaldehyde





Cyclemax
7775-00-0
0.018200
0.32
0.40

Cyclo Galbanate
68901-15-5
0.003230
0.20
0.20

Cymal
103-95-7
0.008810
1.61
2.01

Ethyl Linalool
10339-55-6
0.005200
8.03
10.03

Florhydral
125109-85-5
0.020700
0.16
0.20

Geraniol
106-24-1
0.013300
4.01
5.02

Geranyl Acetate
105-87-3
0.009760
3.21
4.01

Helional
1205-17-0
0.002700
4.01
5.02

Hydroxycitronellal
107-75-5
0.003180
3.21
4.01

Indol
120-72-9
0.029800
0.10
0.10

Jasmal
18871-14-2
0.004340
3.21
4.01

Majantol
103694-68-4
0.002240
3.21
4.01

Phenyl Ethyl
103-45-7
0.056400
0.40
0.40

Acetate





Phenyl Ethyl
60-12-8
0.074100
14.45
18.06

Alcohol





Florosa Q
63500-71-0
0.005570
0
9.03





Total Moderate Volatility Fragrance Materials
54.2%
76.4%







Ambrettolide
28645-51-4
0.000001
1.00
1.00

Cis-3-Hexenyl
65405-77-8
0.000246
1.00
0.50

Salicylate





Benzyl Salicylate
118-58-1
0.00017500
16.61
2.51

Hedione ® Hc
24851-98-7
0.000710
8.03
4.01

Iso-E Super ®
54464-57-2
0.000538
10.03
5.02





Total Low Volatile Fragrance Materials
36.7%
13.0%

Total
100
100





































































































TABLE 11



Fragrance Example 6 (10 Volatile Fragrance Materials)








Vapor Pressure
Parts

Ingredients
CAS Number
(Torr at 25° C.)
(wt %)








Tetra-Hydro
78-69-3
0.115
9.85

Linalool




Terpinyl acetate
80-26-2
0.0392
12.21

Dimethyl Benzyl
151-05-3
0.0139
11.96

Carbinyl Acetate




Dimethyl Benzyl
100-86-7
0.0888
9.35

Carbinol




Phenyl Ethyl
60-12-8
0.074100
7.60

alcohol




Laevo Carvone
6485-40-1
0.0656
9.35

Indole
120-72-9
0.0298
7.29

Ethyl Safranate
35044-59-8
0.0266
12.09

Indocolore
2206-94-2
0.0255
10.09

Eugenol
97-53-0
0.0104
10.21




Total
100.00















































TABLE 12



Fragrance Example 7 (Fresh Floral GF 6-7 Accord-40.14 wt % of

Low Volatile Fragrance Materials)








Vapor Pressure
Parts

Ingredients
CAS Number
(Torr at 25° C.)
(wt %)








Ligustral or
68039-49-6
0.578000
0.15

Triplal




Benzyl acetate
140-11-4
0.164000
0.31

Verdox
88-41-5
0.103000
5.38

Phenethyl alcohol
60-12-8
0.074100
1.54

Indole
120-72-9
0.029800
0.02

Heliotropin
120-57-0
0.010400
1.23

gamma-
706-14-9
0.008520
0.38

Decalactone




Florol
63500-71-0
0.005570
15.38

Ethyl linalool
10339-55-6
0.005200
26.15

Isoeugenol
97-54-1
0.005190
0.08

alpha-Irone
79-69-6
0.004190
1.54

Vanillin
121-33-5
0.001940
6.15

Dimethyl benzyl
10094-34-5
0.001680
1.54

carbinyl butyrate




Methyl beta-
93-08-3
0.000957
0.77

naphthyl ketone




Methyl
24851-98-7
0.000710
30.60

dihydrojasmonate




Benzyl salicylate
118-58-1
0.000175
7.69

Polysantol
107898-54-4
0.000117
0.77

Lrg 201
4707-47-5
0.000029
0.31




Total
100.00

























































TABLE 13



Fragrance Example 8 (Traditional Floral Accord-54.00 wt %

of Low Volatile Fragrance Materials)








Vapor Pressure
Parts

Ingredients
CAS Number
(Torr at 25° C.)
(wt %)








Benzyl acetate
140-11-4
0.1640
5.5

Linalool
78-70-6
0.0905
5.0

Phenethyl alcohol
60-12-8
0.0741
8.0

Indole
120-72-9
0.0298
0.5

α-Terpineol
98-55-5
0.0283
1.5

Geranyl acetate
105-87-3
0.0256
2.5

Cymal
103-95-7
0.00881
3.0

Hydroxycitronellal
107-75-5
0.00318
11.5

Majantol
103694-68-4
0.00224
8.5

Hexyl cinnamic
101-86-0
0.000697
4.0

aldehyde




iso gamma super
68155-66-8
0.000565
12.50

Sandalore
65113-99-7
0.000625
18.75

Habanolide
111879-80-2
0.00000431
18.75




Total
100.00
















































TABLE 14



Fragrance Examples 9, 10, 11 and 12

(Traditional Flora Magnifica-Greater than

30 wt % of Low Volatile Fragrance Materials)








Fragrance
Fragrance
Fragrance
Fragrance


Example
Example
Example
Example


9
10
11
12

Ingredients
Weight %
Weight %
Weight %
Weight %









Traditional Flora
86.96
83.33
74.07
68.97

Magnifica 1





Ethylene Brassylate
4.35
4.167
3.704
6.90

Methyl Dihydro
4.35
8.33
14.82
13.79

Jasmonate





Iso E super
4.35
4.167
7.407
10.35

Total
100
100
100
100.00

Wt % Low Volatile
44.33
46.66
52.60
55.87

Fragrance Materials





Wt % Moderate
49.57
47.50
42.22
39.31

Volatile





Fragrance Materials





Wt % High Volatile
6.09
5.83
5.18
4.83

Fragrance Materials







1 Fragrance Example 4a.














































TABLE 15



Fragrance Examples 13, 14, 15 and 16 (Traditional

Muguesia Magnifica-Greater than 30 wt %

of Low Volatile Fragrance Materials)








Fragrance
Fragrance
Fragrance
Fragrance


Example
Example
Example
Example


13
14
15
16

Ingredients
Weight %
Weight %
Weight %
Weight %









Traditional
86.96
83.33
74.07
68.97

Muguesia





Magnifica 1





Ethylene
4.35
4.17
3.70
6.90

Brassylate





Methyl Dihydro
4.35
8.33
14.82
13.79

Jasmonate





Iso E super
4.35
4.17
7.41
10.35

Total
100.00
100.00
100.00
100.00

Wt % Low
45.23
47.50
53.34
49.08

Volatile Fragrance





Materials





Wt % Moderate
46.96
45.00
40.00
37.24

Volatile





Fragrance





Materials





Wt % High
7.83
7.50
6.67
6.21

Volatile Fragrance





Materials



1 Fragrance Example 5a














































Fragrance example 17 (as disclosed in Table 16) is composed of 30.28 wt % of high volatile fragrance materials, 38.21 wt % of moderate volatile fragrance materials and 31.48 wt % of low volatile fragrance materials, wherein the wt % is relative to the total weight of the fragrance component.





TABLE 16



Fragrance Example 17 (Comparative Fragrance 1-31.48 wt % of Low Volatile

Fragance Materials)








Vapor
Amount








CAS
Pressure
Parts by
Parts

Ingredients
Number
(Torr at 25° C.)
Weight
(wt %)









Limonene
5989-27-5
1.541
2576
30.04

Cis-3-Hexenol
928-96-1
1.039
21
0.24

Zestover 6
78-70-6
0.578
1
0.01

Linalol
78-70-6
0.0905
553
6.45

Aphermate 4 (10% DIPG) 7
25225-08-5
0.0678
7
0.08

Cyclosal
535-86-4
0.0311
35
0.41

Coranol
83926-73-2
0.0210
371
4.33

Sclareolate ®* 1
319002-92-1
0.0196
630
7.35

3-Methoxy-7,7-dimethyl-l 0-
216970-21-7
0.0196
371
4.33

methylene-bicyclo[4.3.1]decane





Cedramber 2
19870-74-8
0.0128
1050
12.24

Ambrox ®*
3738-00-9
0.00934
1
0.01

Decal
706-14-9
0.00852
21
0.24

Damascone Alpha* (10% DIPG) 7
24720-09-0
0.00830
9.1
0.11

(Methoxymethoxy)Cyclododecane
42604-12-6
0.00686
182
2.12

Lilial ®
80-54-6
0.00444
26
0.30

γ-Undecalactone*
104-67-6
0.00271
21
0.24

Calone ® 3
28940-11-6
0.000831
50
0.58

Paradisone 5 ®*
24851-98-7
0.000710
1000
11.66

Galaxolide ® (70% MIP Extra) 7
1222-05-5
0.000414
700
8.16

Exaltenone
14595-54-1
0.0000964
950
11.08





Total
8575.10
100 wt %



* origin: Firmenich SA (Geneva, Switzerland).

1 Propyl (S)-2-(1,1-dimethylpropxy)propanoate.

2 8-Methoxy-2,6,6,8-tetramethyl-tricyclo[5.3.1.0(1,5)]undecane.

3 7-Methyl-2H,4H-1,5-benzodioxepin-3-one.

4 1-(3,3-dimethyl-1-cyclohexyl)ethyl formate; origin: International Flavors & Fragrances.

5 Methyl dihydrojasmonate.

6 Linalool.

7 Fragrance materials added as dilutions in a non-volatile solvent. For the purposes of calculating the fragrance oil composition actual fragrance materials levels added are used.




























































Fragrance example 18 (as disclosed in Table 17) is composed of 26.71 wt % of high volatile fragrance materials, 63.88 wt % of moderate volatile fragrance materials and 9.37 wt % of low volatile fragrance materials, wherein the wt % is relative to the total weight of the fragrance component.





TABLE 17



Fragrance Example 18 (Comparative Fragrance 2-9.37 wt % of Low Volatile

Fragance Materials)








Vapor
Amount








CAS
Pressure
Parts by
Parts

Ingredients
Number
(Torr at 25° C.)
Weight
(wt %)









D-Limonene
5989-27-5
1.540
50.00
5.21

cis-3-Hexenol (10% in DPG) 4
928-96-1
1.040
0.5
0.05

Acetophenone (10% in DPG) 4
98-86-2
0.299
1.00
0.10

Methylphenyl Acetate
101-41-7
0.176
10.00
1.04

Dihydromyrcenol
18479-58-8
0.166
50.00
5.21

Benzyl acetate
140-11-4
0.164
60.00
6.25

Tetra-Hydro Linalool
n/a
0.115
50.00
5.21

n-Undecanal
n/a
0.102
5.00
0.52

Linalool
78-70-6
0.0905
40.00
4.17

Phenylethyl Alcohol
60-12-8
0.0741
245.00
25.53

Allyl amyl glycolate (10% in
67634-00-8
0.04000
2.00
0.21

DPG) 4





Indole (10% in DPG) 4
120-72-9
0.02980
1.00
0.10

Alpha-Terpineol
98-55-5
0.02830
30.00
3.13

Diphenyl Oxide
101-84-8
0.02230
5.00
0.52

L-Citronellol
7540-51-4
0.01830
80.00
8.34

Beta-Ionone
14901-07-6
0.01690
5.00
0.52

Alpha-Ionone
127-41-3
0.01440
15.00
1.56

Dimethyl benzyl carbinyl acetate
151-05-3
0.01390
30.00
3.13

Geraniol
106-24-1
0.01330
40.00
4.17

Nerol
n/a
0.01330
20.00
2.08

Lilial ® 1
80-54-6
0.00444
60.00
6.25

Gamma-Undecalactone
104-67-6
0.00271
15.00
1.56

Amyl salicylate
2050-08-0
0.00144
25.00
2.61

Galaxolide ®
1222-05-5
0.000414
20.00
2.08

cis-3-Hexenyl salicylate
65405-77-8
0.000246
20.00
2.08

Ethylene Brassylate
105-95-3
0.00000000313
30.00
3.13

Styrolyl Acetate 5
n/a
n/a
20.00
2.08

Decenol trans-9 3
n/a
n/a
15.00
1.56

Geranium oil 2
n/a
n/a
15.00
1.56





Total
959.5
100 wt %



1 Benzenepropanal, 4-(1,1-dimethylethyl)-α-methyl-.

2 Natural oil that is judged to be volatile for the purposes of calculating levels of the volatile fragrance materials.

3 Proprietary oil that is judged to be volatile for the purposes of calculating levels of the volatile fragrance materials.

4 Fragrance materials added as dilutions in a non-volatilee solvent. For the purposes of calculating the fragrance oil composition actual fragrance materials levels added are used.

5 Unknown oil that is judged to be of low volatility for the purposes of calculating levels of the volatile fragrance materials.


































































Example 2—Compositions Comprising Fragrance Oils and Substantially Non-Odorous Fragrance Modulators
Compositions A1, D1, G1, J1 and M1 are examples of fragrance compositions according to the present invention, made with any one of fragrance examples 1-3, 4b, 5b and 18, respectively. Compositions B, E, H, K and N are examples of fragrance compositions containing any one of the following fragrance examples 4a, 5a, and 7-17, and which are outside the scope of the present invention. In parallel, control compositions C1, F1, I1, L1 and O1 are prepared by replacing the different substantially non-odorous fragrance modulators by the same amount of deionized water. All of the compositions are prepared by admixture of the components described in Table 18(a), in the proportions indicated.





TABLE 18(a)



Fragrance Compositions





Fragrance Composition (wt %) 1


















Ingredients
A1
B1
C1
D1
E1
F1
G1
H1
I1
J1
K1
L1
M1
N1
O1



Fragrance
5-10
—
—
0.01-2
—
—
3-10
—
—
5-10
—
—
0.1-5
—
—

A1 2

Fragrance
—
5-10
—
—
0.01-2
—
—
3-10
—
—
5-10
—
—
0.1-5
—

B 3

Fragrance
—
—
5-10
—
—
0.01-2
—
—
3-10
—
—
5-10
—
—
0.1-5

A1 or B




Ethanol
60-99.99

Butylated
0-0.07

Hydroxy

Toluene


















Modulator
2-20
2-20
—
—
—
—
—
—
—
—
—
—
—
—
—

A 4

Modulator
—
—
—
0.1
0.1
—
—
—
—
—
—
—
—
—
—

B 5

Modulator
—
—
—
—
—
—
0.1-5
0.1-5
—
—
—
—
—
—
—

C 6

Modulator
—
—
—
—
—
—
—
—
—
2-10
2-10
—
—
—
—

D 7

Modulator
—
—
—
—
—
—
—
—
—
—
—
—
0.1-3
0.1-3
—

E 8




Deionized
to 100.00

water



1 Wt % is relative to the total weight of the composition.

2 Can be any one of fragrance examples 1-3, 4b, 5b, and 18.

3 Can be any one of fragrance examples 4a, 5a, and 7-17.

4 Can be any one of the substantially non-odorous fragrance modulators examples: sucrose laurate; sucrose dilaurate, sucrose myristate, sucrose palmitate, sucrose sterate; sucrose distearate; or sucrose tristearate.

5 Substantially non-odorous fragrance modulator is (E)-1-(2,2,6-trimethylcyclohexyl)oct-1-en-3-one.

6 Can be any one of the substantially non-odorous fragrance modulators examples: 2-(1-menthoxy) ethane-1-ol; 1-(1-menthoxy) propane-2-ol; 3-(1-menthoxy) propane-1-ol; 3-(1-menthoxy) propane-1,2-diol; 2-methyl-3-(1-menthoxy)propane-1,2-diol; or 4-(1-menthoxy) butane-1-ol.

7 Substantially non-odorous fragrance modulator is Hydroquinone beta-D-glycoside.

8 Substantially non-odorous fragrance modulator is Hyaluronic acid disaccharide sodium salt or Sodium Hyaluronate (20-50 kDa).





























































Compositions A2, D2, G2, J2 and M2 are examples of fine fragrance compositions according to the present invention, made with any of the fragrance examples 1 to 3, 4b, 5b, and 18 respectively. Compositions B2, E2, H2, K2 and N2 are examples of fragrance compositions containing traditional or higher levels of low volatile fragrance materials, made with any of the fragrance examples 4a, 5a, and 7-17, respectively. In parallel, control compositions C2, F2, I2, L2 and O2 are prepared by replacing the different substantially non-odorous fragrance modulators by the same amount of deionized water. All of the compositions are prepared by admixture of the components described in Table 18(b), in the proportions indicated.





TABLE 18(b)



Fragrance Compositions





Fragrance Composition (wt %) 1


















Ingredients
A2
B2
C2
D2
E2
F2
G2
H2
I2
J2
K2
L2
M2
N2
O2



Fragrance
5-10
—
—
5-15
—
—
2.5-10
—
—
5-20
—
—
0.1-20
—
—

A1 2

Fragrance
—
5-10
—
—
5-15
—
—
2.5-10
—
—
5-20
—
—
0.1-20
—

B 3

Fragrance
—
—
5-10
—
—
5-15
—
—
2.5-10
—
—
5-20
—
—
0.1-20

A1 or B




Ethanol
60-99.9

Butylated
0-0.07

Hydroxy

Toluene


















Modulator
5-20
5-20
0
—
—
—
—
—
—
—
—
—
—
—
—

A 4

Modulator
—
—
—
0.5-5
0.5-5
0
—
—
—
—
—
—
—
—
—

B 5

Modulator
—
—
—
—
—
—
0.1-3.0
0.1-3.0
0
—
—
—
—
—
—

C 6

Modulator
—
—
—
—
—
—
—
—
—
2.5-15
2.5-15
0
—
—
—

D 7

Modulator
—
—
—
—
—
—
—
—
—
—
—
—
0.1-20
0.1-20
0

E 8




Deionized
to 100.00

water



1 Wt % is relative to the total weight of the composition.

2 Can be any one of fragrance examples 1-3, 4b, 5b, and 18.

3 Can be any one of fragrance examples 4a, 5a, and 7-17.

4 Can be any one of the substantially non-odorous fragrance modulators examples: Propylene Glycol Propyl Ether, Hexaethylene glycol monododecyl ether, Panthenol Ethyl Ether, DL-Panthenol, Diisobutyl Adipate, or Diisoamyl Adipate.

5 Neopentyl Glycol Diisononanoate.

6 2-ethylhexyloxypropanediol.

7 PPG-11 Stearyl Ether.

8 Can be any one of the substantially non-odorous fragrance modulators examples: Dicetyl Ether; Polyglycerin-4 Ethers; Isoceteth-5; Isoceteth-7, Isoceteth-10; Iscoeteth-12; Isoceteth-15; Isoceteth-20; Isoceteth-25; Isoceteth-30; Disodium Lauroamphodipropionate; Hexaethylene glycol monododecyl ether; or Cetearyl Ethylhexnoate.





























































Composition A3 is an example of a fragrance composition according to the present invention, made with any of the fragrance examples 1-3, 4b, 5b and 18, respectively. Composition B3 is an example of a fragrance composition containing traditional or higher levels of low volatile fragrance materials, made with any of the fragrance examples 4a, 5a, and 7-17, respectively. In parallel, a control composition C3 is prepared by replacing the different substantially non-odorous fragrance fixative by the same amount of deionized water. All of the compositions are prepared by admixture of the components described in Table 18(c) in the proportions indicated.





TABLE 18(c)



Fragrance Composition







Fragrance Composition



(wt %) 1








Ingredients
A3
B3
C3





Fragrance A1 2
2-15
—
—


Fragrance B 3
—
2-15
—


Fragrance A1 or B
—
—
2-15






Ethanol
60-99.99


Butylated Hydroxy
0-0.07


Toluene









Modulator A 4
0.1-20
0.1-20
—






Deionized water
to 100.00





1 Wt % is relative to the total weight of the composition.


2 Can be any one of fragrance examples 1-3, 4b, 5b, and 18.


3 Can be any one of fragrance examples 4a, 5a, and 7-17.


4 Can be any one of the substantially non-odorous fragrance modulator as disclosed in Table 4(b).












































Compositions A4, D4, G4, and J4 are examples of fragrance compositions according to the present invention, made with any one of fragrance examples 1-3, 4b, 5b, and 18, respectively. Compositions B4, E4, H4, and K4 are examples of fragrance compositions containing any one of the following fragrance examples 4a, 5a, and 7-17, and which are outside the scope of the present invention. In parallel, control compositions C4, F4, I4, and L4 are prepared by replacing the different substantially non-odorous fragrance modulators by the same amount of deionized water or ethanol. All of the compositions are prepared by admixture of the components described in Table 18(d), in the proportions indicated.





TABLE 18(d)



Fragrance Compositions





Fragrance Composition (wt %) 1















Ingredients
A4
B4
C4
D4
E4
F4
G4
H4
I4
J4
K4
L4



Fragrance
7
—
—
7
—
—
7
—
—
7
—
—

A1 2

Fragrance B 3
—
7
—
—
7
—
—
7
—
—
7
—

Fragrance
—
—
7
—
—
7
—
—
7
—
—
7

A1 or B




Ethanol
75

Butylated
0-0.07

Hydroxy

Toluene















PPG-20
15
15
0
—
—
—
—
—
—
—
—
—

Methyl

Glucose

Ether 4

Caprylyl/Capryl
—
—
—
15
15
0
—
—
—
—
—
—

Glucoside 5

Undecyl
—
—
—
—
—
—
15
15
0
—
—
—

Glucoside 6

Isocetyl
—
—
—
—
—
—
—
—
—
15
15
0

Aclohol 7




Deionized
to 100.00

water



1 Wt % is relative to the total weight of the composition.

2 Can be any one of fragrance examples 1-3, 4b, 5b, and 18.

3 Can be any one of fragrance examples 4a, 5a, and 7-17.

4 Available as GLUCAM ™ P-20.

5 Available as Plantacare ® 810 UP.

6 Available as Simulsol ® SL 11W.

7 Available as Ceraphyl ® ICA.



























































Compositions A5 is an example of a fragrance composition according to the present invention, made with any one of fragrance examples 1-3, 4b, 5b, and 18, respectively. Compositions C5 is an example of a fragrance composition containing traditional or higher levels of low volatile fragrance materials, made with any one of the following fragrance examples 4a, 5a, and 7-17, respectively. In parallel, control compositions C5 is prepared by replacing the different substantially non-odorous fragrance modulator by the same amount of deionized water. All of the compositions are prepared by admixture of the components described in Table 18(e), in the proportions indicated.





TABLE 18(e)



Fragrance Composition







Fragrance Composition



(wt %) 1








Ingredients
A5
B5
C5





Fragrance A1 2
2-15
—
—


Fragrance B 3
—
2-15
—


Fragrance A1 or B
—
—
2-15






Ethanol
60-99.99


Butylated Hydroxy
0-0.07








Toluene





Modulator A 4
0.1-20
0.1-20
—






Deionized water
to 100.00





1 Wt % is relative to the total weight of the composition.


2 Can be any one of fragrance examples 1-3, 4b, 5b, and 18.


3 Can be any one of fragrance examples 4a, 5a, and 7-17.


4 Can be any one of the substantially non-odorous fragrance modulators nos. 1, 3, 7, 8, 99, 100, and 101-103 as disclosed in Table 4(a).












































Tables 19(a) provides test compositions (MOD1 to MOD3) comprising the volatile fragrance formulation of fragrance example 6 (as disclosed in Table 11) with a substantially non-odorous fragrance modulator (as disclosed in Tables 4(a) and 4(b)) that are particularly suited to analytical measurements. All of the compositions are prepared by admixture of the components described in Table 19(a) in the proportions indicated.





TABLE 19(a)



Fragrance Example (Compositions Comprising 10

Volatile Fragrance Materials)






Test composition
Reference composition


(wt % 1 )
(wt % 1 )

Ingredients
MOD 1 to 3
REF







Fragrance A 2
7.0
7.0

Triethyl citrate
0.25 to 1.0
0.25 to 1.0

Ethanol
75.0
75.0

Modulator 3
15.0
0.0

Water
qsp
qsp

Total
100.0
100.0



1 Wt % is relative to the total weight of the composition.

2 Fragrance Example 6 (as disclosed in Table 11).

3 Can be any one of the substantially non-odorous fragrance modulator nos. 7, 8 and 100 as disclosed in Table 4(a).

































Tables 19(b) provides test compositions comprising the volatile fragrance formulation of fragrance example 6 (as disclosed in Table 11) with a substantially non-odorous fragrance modulator (as disclosed in Tables 4(a) and 4(b)) that are particularly suited to analytical measurements. All of the compositions are prepared by admixture of the components described in Table 19(b) in the proportions indicated.





TABLE 19(b)



Compositions comprising fragrance with 10 Volatile Fragrance Materials






Test composition
Reference composition

Ingredients
(wt % 1 )
(wt % 1 )







Fragrance A 2
7.0
7.0

Triethyl citrate
0.25 to 1.0
0.25 to 1.0

Ethanol
75.0
75.0

Modulator 3
1-15.0
0.0

Water
qsp
qsp

Total
100.0
100.0



1 Wt % is relative to the total weight of the composition.

2 Fragrance Example 6 (as disclosed in Table 11).

3 Can be any one of the substantially non-odorous fragrance modulator nos. 1-6, 9-99, and 101-103 as disclosed in Table 4(a) and substantially non-odorous fragrance modulator nos. 1-189 as disclosed in Table 4(b).































Example 3—Single Fragrance Material Compositions Containing Substantially Non-Odorous Fragrance Modulators
Compositions A6, C6, E6, and G6-L6 are examples of compositions according to the present invention, made with single fragrance materials and the substantially non-odorous fragrance modulators, respectively. In parallel, control Compositions B6, D6, F6 and M6 are prepared without a substantially non-odorous fragrance modulator as a control. All the compositions are prepared by admixture of the components in Table 20, in the proportions indicated.





TABLE 20



Single Fragrance Material Compositions





Single PRM Composition (wt %) 1
















Ingredients
A6
B6
C6
D6
E6
F6
G6
H6
I6
J6
K6
L6
M6



Dimethyl
1
1
—
—
—
—
—
—
—
—
—
—
—

Benzyl

Carbinol

Ethyl Safranate
—

1
1
—
—
—
—
—
—
—
—
—

Phenylethyl
—
—
—
—
1
1
—
—
—
—
—
—
—

alcohol

Eugenol
—
—
—
—
—
—
—
—
—
—
—
1
1

Fragrance C 6
—
—
—
—
—
—
0.5-1
0.5-1
0.5-1
0.5-1
0.5-1
—
—

Sucrose
3.8
0
3.0
0
4.6
0
—
—
—
—
—
—
—

Myristate

Modulator A2 2
—
—
—
—
—
—
1-5
—
—
—
—
—
—

Modulator B 3
—
—
—
—
—
—
—
0.1
—
—
—
—
—

Modulator C 4
—
—
—
—
—
—
—
—
0.1-5
—
—
—
—

Modulator D 5
—
—
—
—
—
—
—
—
—
1-4
—
1.6
0

Modulator E 7










0.1-3
—
—




Ethanol
to 100



1 Wt % is relative to the total weight of the composition.

2 Can be any one of the substantially non-odorous modulators examples: sucrose laurate, sucrose dilaurate, sucrose palmitate, sucrose stearate, sucrose distearate, or sucrose tristearate.

3 Can be any one of the substantially non-odorous modulators examples: (E)-1-(2,2,6-trimethylcyclohexyl)oct-1-en-3-one.

4 Can be any one of the substantially non-odorous modulators examples: 2-(1-menthoxy) ethane-1-ol; 1-(1-menthoxy) propane-2-ol; 3-(1-menthoxy) propane-1-ol; 3-(1-menthoxy) propane-1,2-diol; 2-methyl-3-(1-menthoxy)propane-1,2-diol; or 4-(1-menthoxy) butane-1-ol.

5 Substantially non-odorous fragrance modulator is Hydroquinone beta-D-glycoside (available as Arbutin from Sigma-Aldrich).

6 Can be any one of the single fragrance materials: Dimethyl Benzyl Carbinol; Ethyl Safranate, Phenyl ethyl alcohol or Eugenol.

7 Substantially non-odorous fragrance modulator is Hyaluronic acid disaccharide sodium salt or Sodium Hyaluronate (20-50 kDa).
















































Compositions A7, C7 and E7-I7 are examples of compositions according to the present invention, made with single fragrance materials and the substantially non-odorous fragrance modulators, respectively. In parallel, control Compositions B7, D7 and J7 are prepared without a substantially non-odorous fragrance modulator as a control. All the compositions are prepared by admixture of the components in Table 21, in the proportions indicated.





TABLE 21



Single Fragrance Material Compositions





Single PRM Composition (wt %) 1













Ingredients
A7
B7
C7
D7
E7
F7
G7
H7
I7
J7



Dimethyl
—
—
1.0
1.0
—
—
—
—
—
—

Benzyl

Carbinyl

Acetate

Eugenol
1.0
1.0
—
—
—
—
—
—
—
—

Fragrance C 6
—
—
—
—
0.1-1
0.1-1
0.1-1
0.1-1
0.1-1
0.1-1

Propylene
0.8
0.0
—
—
—
—
—
—
—
—

Glycol Propyl

Ether

Diisobutyl
—
—
1.4
0.0
—
—
—
—
—
—

adipate

Modulator A2 2
—
—
—
—
0.1-5
—
—
—
—
0

Modulator B 3
—
—
—
—
—
0.1-5
—
—
—
0

Modulator C 4
—
—
—
—
—
—
0.1-5
—
—
0

Modulator D 5
—
—
—
—
—
—
—
0.1-5
—
0

Modulator E 7
—
—
—
—
—
—
—
—
0.1-5
0




Ethanol
to 100



1 Wt % is relative to the total weight of the composition.

2 Can be any one of the substantially non-odorous modulators examples: Hexaethylene glycol monododecyl ether, Panthenol Ethyl Ether, DL-Panthenol, or Diisoamyl Adipate.

3 Neopentyl Glycol Diisononanoate.

4 2-ethylhexyloxypropanediol.

5 PPG-11 Stearyl Ether.

6 Can be any one of the single fragrance materials examples: Dimethyl Benzyl Carbinyl Acetate or Eugenol.

7 Can be any one of the substantially non-odorous modulators examples: Dicetyl Ether; Polyglycerin-4 Ethers; Isoceteth-5; Isoceteth-7, Isoceteth-10; Isoceteth-12; Isoceteth-15; Isoceteth-20; Isoceteth-25; Isoceteth-30; Disodium Lauroamphodipropionate; Hexaethylene glycol monododecyl ether or Cetearyl Ethylhexnoate.

















































Compositions A8, C8, E8, G8, I8, K8, M8, Q8, S8, U8, W8, Y8, AA8, and CC8 are examples of compositions according to the present invention, made with single fragrance materials and the substantially non-odorous fragrance fixatives, respectively. In parallel, control Compositions B8, D8, F8, H8, J8, L8, N8, P8, R8, T8, V8, X8, Z8, BB8, and DD8 are prepared without a substantially non-odorous fragrance fixative as a control. All of the compositions are prepared by admixture of the components in Tables 22(a) and 22(b), in the proportions indicated





TABLE 22(a)



Single Fragrance Material Compositions





Single Fragrance Material Composition (wt % 1 )



















Ingredients
A8
B8
C8
D8
E8
F8
G8
H8
I8
J8
K8
L8
M8
N8
O8
P8



Dimethyl Benzyl
1
1
—
—
—
—
—
—
1
1
—
—
—
—
—
—

Carbinol

Eugenol
—

1
1
—
—
—
—
—
—
1
1
—
—
—
—

Phenylethyl
—
—
—
—
1
1
—
—
—
—
—
—
1
1
—
—

Alchol

Fragrance A 2
—
—
—
—
—
—
1
1
—
—
—
—
—
—
1
1

Piperonyl
2.2
0
2.0
0
2.2
0
0.5-5
0
—
—
—
—
—
—
—
—

butoxide

Poly(PG)monobutyl
—
—
—
—
—
—
—
—
2.2
0
2.0
0
1.8
0
0.5-5
0

ether




Ethanol
to 100



1 Wt % is relative to the total weight of the composition.

2 Can be any one of the single fragrance materials of Table 2 or 3.











































TABLE 22(b)



Single Fragrance Material Compositions





Single Fragrance Material Composition (wt % 1 )

















Ingredients
Q8
R8
S8
T8
U8
V8
W8
X8
Y8
Z8
AA8
BB8
CC8
DD8



Indole
1
1
—
—
—
—
—
—
1
1
—
—
—
—

Eugenol
—
—
1
1
—
—
—
—
—
—
1
1
—
—

Dimethyl
—
—
—
—
1
1
—
—
—
—
—
—
1
1

Benzyl

Carbinol

Phenylethyl
—
—
—
—
—
—
1
1
—
—
—
—
—
—

Alchol

Triglycol
1.3
—
0.9
—
1.0
—
1.2
—
—
—
—
—
—
—




Ethanol
To 100



1 Wt % is relative to the total weight of the composition.



































Compositions A9, C9, E9, G9 and 19 are examples of compositions according to the present invention, made with single fragrance materials and the substantially non-odorous fragrance modulators, respectively. In parallel, control Compositions B9, D9, F9, H9 and J9 are prepared without a substantially non-odorous fragrance modulator as a control. All the compositions are prepared by admixture of the components in Table 22(c), in the proportions indicated.





TABLE 22(c)



Single Fragrance Material Compositions





Single Fragrance Material Composition (wt %) 1













Ingredients
A9
B9
C9
D9
E9
F9
G9
H9
I9
J9



Indocolore
1.0
1.0
—
—
—
—
—
—
—
—

Dimethyl Benzyl
—
—
1.0
1.0
—
—
—
—
—
—

Carbinol

Eugenol
—
—
—
—
1.0
1.0
—
—
—
—

Phenylethyl
—
—
—
—
—
—
1.0
1.0
—
—

alcohol

Fragrance C 2
—
—
—
—
—
—
—
—
1.0
1.0

Expert Gel ®
5.0
0.0
—
—
—
—
—
—
—
—

EG56 3

Kolliphor ® EL 4
—
—
16.6
0.0
15.2
0.0
13.0
0.0
—
—

Glycerol
—
—
—
—
—
—
—
—
0.1-20
0.0

Alkxoylates 5




Ethanol
to 100



1 Wt % is relative to the total weight of the composition.

2 Can be any one of the single fragrance materials examples: Indocolore, Dimethyl Benzyl Carbinol, Eugenol or Phenethyl alcohol.

3 Chemical name is Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer and listed as a substantially non-odorous modulator no. 99 as disclosed in Table 4(a).

4 Chemical name is propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate and listed as a substantially non-odorous modulator no. 100 as disclosed in Table 4(a).

5 Can be any one of the substantially non-odorous modulators examples: 3-((2-ethylhexyl)oxy)propane-1,2-diol (modulator no. 101 as disclosed in Table 4(a)); 3-((2-propylheptyl)oxy)propane-1,2-diol (modulator no. 102 as disclosed in Table 4(a)); or 1-amino-3-((2-ethylhexyl)oxy)propan-2-ol (modulator no. 103 as disclosed in Table 4(a)).











































Composition A10 is an example of a composition according to the present invention, made with single fragrance material and the substantially non-odorous fragrance modulator, respectively. In parallel, control Composition B10 is prepared without a substantially non-odorous fragrance modulator. All the compositions are prepared by admixture of the components in Table 22(d), in the proportions indicated.





TABLE 22(d)



Single Fragrance Material Compositions





Single Fragrance Material Composition (wt %) 1





Ingredients
A10
B10



Fragrance A 2
1-7
1-7

Modulator 3
1-15.0
0.0




Ethanol
to 100



1 Wt % is relative to the total weight of the composition.

2 Can be any one of the fragrance materials disclosed in Tables 2 and 3.

3 Can be any one of the substantially non-odorous fragrance modulator not already disclosed in Tables 20, 21, and 22(a)-22(c) above.































Example 4—Exemplary Product Compositions
Compositions I, II, III and IV are examples of body spray compositions according to the present invention. They are prepared by admixture of the components described in Table 23, in the proportions indicated.





TABLE 23



Body Spray Compositions






CAS
Compositions (wt % 1 )








Ingredients
Number
I
II
III
IV










Denatured Ethanol
64-17-5
39.70
59.45
39.70
39.70

Water
7732-18-5
—
0.75
—
—

Dipropylene Glycol
25265-71-8
15.00
—
15.00
15.00

Isopropyl Myristate
110-27-0
1.00
—
1.00
1.00

Zinc Phenosulphonate
127-82-2
0.50
—
0.50
0.50

Cavasol ® W7
128446-36-
—
1.00
—
—

methylated
6





Beta-cyclodextrin






Fragrance 2
—
1.20
1.20
1.20
1.20

Fragrance Modulator 3
—
2.60
2.60
2.60
2.60

Propane
74-98-6
4.86
—
4.86
4.86

Isobutane
72-28-5
27.14
—
27.14
27.14

1,1-Difluoroethane
75-37-6
8.00
35.00
8.00
8.00

(HFC-152a)












Total
100.00
100.00
100.00
100.00



1 Wt % relative to the total weight of the composition.

2 Can be any one of Fragrances Examples 1, 2, 3, 4b, 5b or 18.

3 Can be any one of the substantially non-odorous fragrance modulators disclosed in Tables 4(a) and 4(b).














































Composition V, VI and VII are examples of body lotion compositions according to the present invention. They are prepared by admixture of the components as described in Table 24, in the proportions indicated.





TABLE 24



Body Lotion Composition







Compositions (wt % 1 )







Ingredients
CAS Number
V
VI
VII



Water
7732-18-5
qsp 100%
qsp 100%
qsp 100%

Trilon ® B
64-02-8
0.05
0.05
0.05

Carbopol ® ETD 2050
9003-01-4
0.2
0.2
0.2

Pemulen ™ TR1
9063-87-0
0.2
0.2
0.2

Nexbase ® 2008
68037-01-4
8
8
8

Silicone V100
63148-62-9
6
6
6

Fragrance Modulator 3
—
3
3
3

Tris Amino ™ Ultra Pur
102-71-6
0.4
0.4
0.4

Fragrance 2
—
3
3
3

Preservatives
—
qs
qs
qs






Total
100.00
100.00
100.00



1 Wt % relative to the total weight of the composition.

2 Can be any one of the Fragrances Examples 1, 2, 3, 4b, 5b or 18.

3 Can be any one of the substantially non-odorous fragrance modulators disclosed in Tables 4(a) and 4(b).







































Example 5—Olfactive Test Results
Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below.
(a) Effects of the Substantially Non-Odorous Fragrance Modulators on Single Fragrance Material Compositions
FIG. 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer (i.e., Expert Gel® 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance modulator (Expert Gel® 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all these time points.
FIG. 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor® EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance modulator (Kolliphor® EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001), 3 hours (p=0.0265) and 6 hours (p=0.0388) at 95% significance level (i.e., p<0.05) at all these time points.
FIG. 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor® EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance modulator (Kolliphor® EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to suppress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p=0.0025), 1 hour (p<0.0001), 3 hours (p<0.0001) and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all time points.
FIG. 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor® EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator (Kolliphor® EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001) at 95% significance level (i.e., p<0.05) and at 3 hours (p=0.0876) at 90% significance level (i.e., p<0.1).
(b) Effects of the Substantially Non-Odorous Fragrance Modulators on the Fragrance Profile Longevity of Compositions Having Diamond Construction of Fragrance Component Vs. Compositions Having Traditional Levels of Fragrance Component (Greater than 30 wt % Relative to the Total Weight of the Fragrance Component) and No Substantially Non-Odorous Fragrance Modulator
Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile longevity, particularly intensity of the characters attributable to the volatile fragrance materials are maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator.
FIG. 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam™ P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.
FIG. 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam™ P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.
FIG. 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.
FIG. 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.
Panelists are also asked to score the Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 for the intensity of the fragrance profile. The results show the effect of the substantially non-odorous fragrance modulator and excessive levels of low volatile fragrance materials for any one of Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 on fragrance profile longevity and fidelity. Two outcomes are observed: (i) either the fragrance profile longevity is unaffected by the addition of the substantially non-odorous fragrance modulator or (ii) the fragrance profile appears to be suppressed with a loss of strength (data not shown).
Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application.
(c) Effects of the Substantially Non-Odorous Fragrance Modulators on the Fragrance Profile Fidelity of Compositions Having Diamond Fragrance Materials (Between 10 Wt % to 30 wt % Relative to the Total Weight of the Fragrance Component) Vs. Compositions Having Traditional Levels of Low Volatile Fragrance Materials (Greater than 30 wt % Relative to the Total Weight of the Fragrance Component) and No Substantially Non-Odorous Fragrance Modulator
Panelists are are also asked to score the composition for the fragrance profile fidelity. In particular, the panelists are asked to score the dominance of the floral character attributable to the volatile fragrance materials on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond fragrance materials for the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on the floral character dominance versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile fidelity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly floral character attributable to the volatile fragrance materials, are maintained by the substantially non-odorous fragrance modulator over time for up to 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator.
FIG. 10 provides the fragrance fidelity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition C4 comprising the Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 to Composition B4 comprising Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).
FIG. 11 provides the fragrance fidelity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition C4 comprising the Traditional Muguesia Magnifica Fragrance Example 5a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 to Composition B4 comprising Traditional Muguesia Magnifica Fragrance Example 5a does not result in improved fidelity of the floral character (data not shown).
FIG. 12 provides the fragrance fidelity profile of Composition D4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator Caprylyl/Capryl Glucoside (i.e., Plantacare® 810 UP) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Plantacare® 810 UP maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition F4 comprising the Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Plantacare® 810 UP to Composition E4 comprising Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).
FIG. 13 provides the fragrance fidelity profile of Composition G4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator Undecyl Glucoside (i.e., Simulsol® SL 11W) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Simulsol® SL 11W maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition 14 comprising the Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Simulsol® SL 11W to Composition H4 comprising Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).
FIG. 14 provides the fragrance fidelity profile of Composition J4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator Isocetyl Aclohol (i.e., Ceraphyl® ICA) and the Diamond Floral Mangifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Ceraphyl® ICA maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition L4 comprising the Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Ceraphyl® ICA to Composition K4 comprising the Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).
FIG. 15 provides the fragrance fidelity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition C2 comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate to Composition B2 comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).
FIG. 16 provides the fragrance fidelity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition C2 comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate to Composition B2 comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a does not result in improved fidelity of the floral character (data not shown).
FIG. 17 provides the fragrance fidelity profile of Composition J2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator PPG-11 Stearyl Ether and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator PPG-11 Stearyl Ether maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition L2 comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator PPG-11 Stearyl Ether to Composition K2 comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).
FIG. 18 provides the fragrance fidelity profile of Composition J2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator PPG-11 Stearyl Ether and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator PPG-11 Stearyl Ether maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition L2 comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator PPG-11 Stearyl Ether to Composition K2 comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a does not result in improved fidelity of the floral character (data not shown).
Panelists are also asked to score the Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 for the dominance of the floral character. The results show the effect of the substantially non-odorous fragrance modulator and excessive levels of low volatile fragrance materials for any one of Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 on fidelity of the floral character attributable to the volatile fragrance materials. It is observed that the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator does not result in improved fidelity of the floral character as seen in any one of Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 (data not shown).
Panelists are further asked to score the compositions on a scale of 1 to 5, wherein 1 represents the fragrance profile remains unchanged and 5 represents a total change in the fragrance profile versus a control. The results of the panel test are averaged and plotted together with the confidence intervals. The results show the effect of the substantially non-odorous fragrance modulator and diamond fragrance materials for Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2. The presence of the substantially non-odorous fragrance modulator and diamond fragrance materials result in noticeable fidelity in fragrance characters. Particularly, noticeable fidelity in the floral aromas attributable to the volatile fragrance materials (data not shown).
Example 6—Analytical Evaporation Test Results
Using the analytical evaporation Test Method 3, it is possible to measure the amount of each component of a perfume mixture that remains as the fragrance mixture evaporates. Test compositions (MOD1 to MOD3) comprising a mixture of 10 volatile perfume materials, as disclosed in Table 11 (Fragrance Example 6), and a substantially non-odorous fragrance modulators, as disclosed in Tables 4(a) and 4(b), are introduced in the aluminum containers at the set temperature for pre-determined periods of time in accordance with the protocol described in Test Method 3. Indole is one of the components of the 10 PRMs mixture of Table 11. Control compositions containing the full 10 PRMs mixture as disclosed in Table 11 without the substantially non-odorous fragrance modulator are run alongside the test compositions. The average profile for the control composition is plotted against the individual profile for the indole component from the test composition containing the 10 PRMs mixture of Table 11 with the substantially non-odorous fragrance modulators. The error associated with the method is determined by running replicate evaporation experiments on the control composition. An average evaporation profile of the control composition as well as the 95% confidence interval at each time point are calculated from the replicates.
It is useful to consider the difference (Δ) in the % of remaining fragrance material between each of the test composition (MOD) and their respective control composition (REF) at each experimental time points (e.g., 30 mins, 60 mins and 180 mins) to determine the effect of the substantially non-odorous fragrance modulator on the volatile PRMs in a mixture. The difference (Δ) in the % of remaining of a given fragrance material is calculated as follows:
Δ=% remaining of given fragrance material in test composition (MOD)−% remaining of same fragrance material in control composition (REF)

The difference (Δ) can then be plotted (data not shown) for each of the perfume materials in the mixture at each of the time points. For ease of reference, the applicant has summarize the effect of the substantially non-odorous fragrance modulator on only one volatile fragrance component (e.g., indole) of the mixture, to serve as a representative of all of the volatile fragrance materials.
(a) Effect of PPG-3 Myristyl Ether on Compositions Having Volatile Fragrance Materials
FIG. 19 shows the effect of the substantially non-odorous fragrance modulator PPG-3 Myristyl Ether (i.e., available as Tegosoft® APM/Modulator 7 from Table 4(a)) on the evaporation profile for a representative component (i.e., indole) of the test composition (MOD1). With reference to FIG. 19 , PPG-3 Myristyl Ether has a difference (Δ) of 12% after 30 mins, 22% after 60 mins, and 60% after 3 hours. Addition of the PPG-3 Myristyl Ether in the test composition (MOD1) maintains the concentration of the volatile fragrance material indole from 0 hour up to 3 hours whilst the control composition (REF), in the absence of PPG-3 Myristyl Ether, drops in fragrance concentration over the 3 hours. Thus, PPG-3 Myristyl Ether acts to maintain the continued evaporation of the volatile fragrance material over time. Similar results are observed for the other volatile fragrance materials in the mixture (data not shown).
(b) Effect of Neopentvl Glycol Diethylhexanoate on Compositions Having Volatile Fragrance Materials
FIG. 20 shows the effect of the substantially non-odorous fragrance modulator Neopentyl Glycol Diethylhexanoate (i.e., available as Schercemol™ NGDO/Modulator 8 from Table 4(a)) on the evaporation profile for a representative component (i.e., indole) of the test composition (MOD2). With reference to FIG. 20 , Neopentyl Glycol Diethylhexanoate has a difference (Δ) of 11% after 30 mins, 21% after 60 mins, and 53% after 3 hours. Addition of the Neopentyl Glycol Diethylhexanoate in the test composition (MOD2) maintains the concentration of the volatile fragrance material indole from 0 hour up to 3 hours whilst the control composition (REF), in the absence of Neopentyl Glycol Diethylhexanoate, drops in fragrance concentration over the 3 hours. Thus, Neopentyl Glycol Diethylhexanoate acts to maintain the continued evaporation of the volatile fragrance material over time. Similar results are observed for the other volatile fragrance materials in the mixture (data not shown).
(c) Effect of Kolliphor® EL on Compositions Having Volatile Fragrance Materials
FIG. 21 shows the effect of the substantially non-odorous fragrance modulator Kolliphor® EL (disclosed as modulator 99 from Table 4(a)) on the evaporation profile for a representative component (i.e., indole) of the test composition (MOD3). With reference to FIG. 21 , indole has a difference (Δ) of 15% after 30 mins, 28% after 60 mins, and 80% after 3 hours. Addition of the Kolliphor® EL in the test composition (MOD3) maintains the concentration of the volatile fragrance material indole from 0 hour up to 3 hours whilst the control composition (REF), in the absence of Kolliphor® EL, drops in fragrance concentration over the 3 hours. Thus, Kolliphor® EL acts to maintain the continued evaporation of the volatile fragrance material over time. Similar results are observed for the other volatile fragrance materials in the mixture (data not shown).
Example 7—Analytical Headspace Test Results
Using the analytical headspace Test Method 4, it is possible to demonstrate the character retention over time of a perfume mixture of a fragrance composition of the present invention vs. a control. Compositions disclosed in Tables 18(a)-18(e) are added to sealed vials in accordance with the procotol described in the Method Section, and the fragrance profile in the headspace are measured at specific time points through the use of headspace gas chromatography.
(a) Effects of the Substantially Non-Odorous Fragrance Modulators on Character Retention of Compositions Having Diamond Constructions Vs. Compositions Having Traditional Levels of Fragrance Materials
The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly of floral characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator.
FIG. 22( a )( i ) provides the headspace chromatogram for control Composition L2 after 10 mins of evaporation, wherein Composition L2 comprises 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a and no modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxycitronellal; and (2) low volatile fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example: Hedione® HC and Iso-E Super®. As the fragrance evaporates, the height of the peaks reduces significantly, particularly the peaks due to the high and moderate volatile fragrance materials. After 60 mins of evaporation, as shown in FIG. 22( a ) ( ii ), only one substantial moderate volatile fragrance material peak remains, for example Helional. In contrast, the low volatile fragrance materials remain with substantial peaks for many perfume materials, for example Hedione® HC and Iso-E Super®. These chromatograms illustrate the loss of fragrance materials during evaporation, particularly the loss of the moderate volatile fragrance materials. Olfactively this is perceived as a loss in intensity and perception of these particular fragrance materials, particularly those that provide the floral characters.
FIG. 22( b )( i ) provides the headspace chromatogram for inventive Composition J2 after 10 mins of evaporation, wherein Composition J2 comprises 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b and 15 wt % PPG-11 Stearyl Ether substantially non-odorous fragrance modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxy citronellal; and (2) low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example Hedione® HC and Iso-E Super®. As the fragrance evaporates the height of the peaks reduces but not as much as compared to the control Composition L2, particularly the peaks due to the moderately volatile fragrance materials are maintained. After 60 mins of evaporation, as shown in FIG. 22( b ) ( ii ), most of the moderate volatile fragrance materials peaks remain. This includes Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxy citronellal. The low volatile fragrance materials, Hedione® HC and Iso-E Super®, remain in the headspace but are not dominant when compared to Composition L2. These chromatograms illustrate the prolonged presence of the volatile fragrance materials in Composition J2 and the dominance of the headspace after 60 mins by the moderate volatile fragrance materials at the expense of the low volatile fragrance materials. Consumers will experience this as a fragrance with a prolonged intensity, particularly of the characters attributable to the volatile fragrance materials, most particularly of the floral characters.
FIG. 23( a )( i ) provides the headspace chromatogram for control Composition C4 after 10 mins of evaporation, wherein Composition C4 comprises the Traditional Muguesia Magnifica Fragrance Example 5a and no modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Phenethyl alcohol, Cymal or Jasmal, and hydroxy citronellal and (2) low volatile fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example: Hedione® HC and Iso-E Super®. As the fragrance evaporates, the height of the peaks reduces significantly, particularly the peaks due to the moderate volatile fragrance materials. After 60 mins of evaporation, as shown in FIG. 23( a ) ( ii ), only two small moderate volatile fragrance material peaks remain, Helional and Cyclogalbante or Majantol. In contrast, the low volatile fragrance materials remain with many peaks for many perfume materials, for example Hedione® HC and Iso-E Super®. These chromatograms illustrate the loss of fragrance materials during evaporation, particularly the loss of the moderate volatile fragrance materials. Olfactively this is perceived as a loss in intensity and perception of these particular fragrance materials, particularly those that provide the floral characters.
FIG. 23( b )( i ) provides the headspace chromatogram for inventive Composition A4 after 10 mins of evaporation, wherein Composition A4 comprises the Diamond Muguesia Magnifica Fragrance Example 5b and PPG-20 Methyl Glucose Ether (i.e., GLUCAM™ P-20) substantially non-odorous fragrance modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Phenethyl alcohol, Cymal or Jasmal, and hydroxycitronellal; and (2) low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example Hedione® HC and Iso-E Super®. As the fragrance evaporates the height of the peaks reduces but not as much as compared to the control Composition C4, particularly the peaks due to the moderate volatile fragrance materials are maintained. After 60 mins of evaporation, as shown in FIG. 23( b ) ( ii ), most of the moderate volatile fragrance materials peaks remain. This includes Cyclogalbanate or Majantol®, Phenethyl alcohol, Cymal or Jasmal, and hydroxycitronellal. The low volatile fragrance materials, Hedione® HC and Iso-E Super®, remain in the headspace but are not dominant when compared to Composition C4. These chromatograms illustrate the prolonged presence of the volatile fragrance materials in Composition A4 and the dominance of the headspace after 60 mins by the moderate volatile fragrance materials at the expense of the low volatile fragrance materials. Olfactively this is perceived as a fragrance with a prolonged intensity, particularly of the characters attributable to the moderate volatile fragrance materials, most particularly of the floral characters.
FIG. 24( a )( i ) provides the headspace chromatogram for control Composition L4 after 10 mins of evaporation, wherein Composition L4 comprises the Traditional Floral Magnifica Fragrance Example 4a and no modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Pyranol (Florol), Cyclogalbanate or Majantol®, Cymal or Jasmal, and hydroxycitronellal and (2) low volatile fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example: Hedione® HC and Iso-E Super®. As the fragrance evaporates, the height of the peaks reduces significantly, particularly the peaks due to the moderate volatile fragrance materials. After 60 mins of evaporation, as shown in FIG. 24( a ) ( ii ), only a few small moderate volatile fragrance material peaks remain, Cymal or Jasmal and Helional. In contrast, the low volatile fragrance materials remain with many peaks for many perfume materials, for example Hedione® HC and Iso-E Super®. These chromatograms illustrate the loss of fragrance materials during evaporation, particularly the loss of the moderate volatile fragrance materials. Olfactively this is perceived as a loss in intensity and perception of these particular fragrance materials, particularly those that provide the floral characters.
FIG. 24( b )( i ) provides the headspace chromatogram for inventive Composition J4 after 10 mins of evaporation, wherein Composition J4 comprises the Diamond Floral Magnifica Fragrance Example 4b and Isocetyl Alcohol (i.e., Ceraphyl® ICA) substantially non-odorous fragrance modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Pyranol (Florol), Cyclogalbanate or Majantol®, Cymal or Jasmal, and hydroxy citronellal; and (2) low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example Hedione® HC and Iso-E Super®. As the fragrance evaporates the height of the peaks reduces but not as much as compared to the control Composition C4, particularly the peaks due to the moderate volatile fragrance materials are maintained. After 60 mins of evaporation, as shown in FIG. 24( b ) ( ii ), most of the moderate volatile fragrance materials peaks remain. This includes Pyranol (Florlol), Cyclogalbanate or Majantol®, Cymal or Jasmal, and hydroxy citronellal. The low volatile fragrance materials, Hedione® HC and Iso-E Super®, remain in the headspace but are not dominant when compared to Composition C4. These chromatograms illustrate the prolonged presence of the volatile fragrance materials in Composition A4 and the dominance of the headspace after 60 mins by the moderate volatile fragrance materials at the expense of the low volatile fragrance materials. Olfactively this is perceived as a fragrance with a prolonged intensity, particularly of the characters attributable to the moderate volatile fragrance materials, most particularly of the floral characters.
FIG. 25( a )( i ) provides the headspace chromatogram for control Composition 14 after 10 mins of evaporation, wherein Composition 14 comprises the Traditional Muguesia Magnifica Fragrance Example 5a and no modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal, and hydroxy citronellal and (2) low volatile fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example: Hedione® HC and Iso-E Super®. As the fragrance evaporates, the height of the peaks reduces significantly, particularly the peaks due to the high and moderate volatile fragrance materials. After 60 mins of evaporation, as shown in FIG. 25( a ) ( ii ), only one substantial moderate volatile fragrance material peak remains, Helional. In contrast, the low volatile fragrance materials remain with substantial peaks for many perfume materials, for example Hedione® HC and Iso-E Super®. These chromatograms illustrate the loss of fragrance materials during evaporation, particularly the loss of the moderate volatile fragrance materials. Olfactively this is perceived as a loss in intensity and perception of these particular fragrance materials, particularly those that provide the floral characters.
FIG. 25( b )( i ) provides the headspace chromatogram for inventive Composition G4 after 10 mins of evaporation, wherein Composition G4 comprises the Diamond Muguesia Magnifica Fragrance Example 5b and Undecyl Glucoside (i.e., Simulsol® SL 11W) substantially non-odorous fragrance modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxy citronellal; and (2) low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example Hedione® HC and Iso-E Super®. As the fragrance evaporates the height of the peaks reduces but not as much as compared to the control Composition 14, particularly the peaks due to the moderately volatile fragrance materials are maintained. After 60 mins of evaporation, as shown in FIG. 25( b ) ( ii ), most of the moderate volatile fragrance materials peaks remain. This includes Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxycitronellal. The low volatile fragrance materials, Hedione® HC and Iso-E Super®, remain in the headspace but are not dominant when compared to Composition 14. These chromatograms illustrate the prolonged presence of the volatile fragrance materials in Composition G4 and the dominance of the headspace after 60 mins by the moderate volatile fragrance materials at the expense of the low volatile fragrance materials. Olfactively this is perceived as a fragrance with a prolonged intensity, particularly of the characters attributable to the moderate volatile fragrance materials, most particularly of the floral characters.
It should be understood that every maximum numerical limitation given throughout this specification includes every lower numerical limitation, as if such lower numerical limitations were expressly written herein. Every minimum numerical limitation given throughout this specification will include every higher numerical limitation, as if such higher numerical limitations were expressly written herein. Every numerical range given throughout this specification will include every narrower numerical range that falls within such broader numerical range, as if such narrower numerical.
The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as “40 mm” is intended to mean “about 40 mm.”
Every document cited herein, including any cross referenced or related patent or application and any patent application or patent to which this application claims priority or benefit thereof, is hereby incorporated herein by reference in its entirety unless expressly excluded or otherwise limited. The citation of any document is not an admission that it is prior art with respect to any invention disclosed or claimed herein or that it alone, or in any combination with any other reference or references, teaches, suggests or discloses any such invention. Further, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition assigned to that term in this document shall govern.
While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.