(en)The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

1.ApplicationNumber: US-64264706-A
1.PublishNumber: US-2007124086-A1
2.Date Publish: 20070531
3.Inventor: MENDRICK DONNA L.
PORTER MARK W.
JOHNSON KORY R.
CASTLE ARTHUR
HIGGS BRANDON
ELASHOFF MICHAEL

4.Inventor Harmonized: MENDRICK DONNA L(US)
PORTER MARK W(US)
JOHNSON KORY R(US)
CASTLE ARTHUR(US)
HIGGS BRANDON(US)
ELASHOFF MICHAEL(US)

5.Country: US
6.Claims:
(en)The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

7.Description:
(en)RELATED APPLICATIONS
This application is a continuation of U.S. application Ser. No. 10/301,856, filed Nov. 22, 2002 which is a continuation-in-part of U.S. application Ser. No. 10/152,319, filed May 22, 2002, which claims priority under 35 U.S.C. §119(e) to U.S. Provisional Applications 60/292,335, filed May 22, 2001; 60/297,523, filed Jun. 13, 2001; 60/298,925, filed Jun. 19, 2001; 60/303,810, filed Jul. 10, 2001; 60/303,807, filed Jul. 10, 2001; 60/303,808, filed Jul. 10, 2001; 60/315,047, filed Aug. 28, 2001; 60/324,928, filed Sep. 27, 2001; 60/330,867, filed Nov. 1, 2001; 60/330,462, Oct. 22, 2001; 60/331,805, filed Nov. 21, 2001; 60/336,144, filed Dec. 6, 2001; 60/340,873, filed Dec. 19, 2001; 60/357,843, filed Feb. 21, 2002; 60/357,842, filed Feb. 21, 2002; 60/357,844, filed Feb. 21, 2002; 60/364,134 filed Mar. 15, 2002; 60/370,206, filed Apr. 8, 2002; 60/370,247, filed Apr. 8, 2002; 60/370,144, filed Apr. 8, 2002; 60/371,679, filed Apr. 12, 2002; and 60/372,794, filed Apr. 17, 2002, all of which are herein incorporated by reference in their entirety.


SEQUENCE LISTING SUBMISSION ON COMPACT DISC
The Sequence Listing submitted concurrently herewith on compact disc under 37 C.F.R. §§1.821(c) and 1.821(e) is herein incorporated by reference in its entirety. The compact disc copy of the Sequence Listing in this application, is identical to the computer readable copy of the Sequence Listing filed in U.S. patent application Ser. No. 10/301,856, filed Nov. 22, 2002. The electronic copy of the Sequence Listing was created on Dec. 21, 2006.
BACKGROUND OF THE INVENTION
The need for methods of assessing the toxic impact of a compound, pharmaceutical agent or environmental pollutant on a cell or living organism has led to the development of procedures which utilize living organisms as biological monitors. The simplest and most convenient of these systems utilize unicellular microorganisms such as yeast and bacteria, since they are the most easily maintained and manipulated. In addition, unicellular screening systems often use easily detectable changes in phenotype to monitor the effect of test compounds on the cell. Unicellular organisms, however, are inadequate models for estimating the potential effects of many compounds on complex multicellular animals, as they do not have the ability to carry out biotransformations.
The biotransformation of chemical compounds by multicellular organisms is a significant factor in determining the overall toxicity of agents to which they are exposed. Accordingly, multicellular screening systems may be preferred or required to detect the toxic effects of compounds. The use of multicellular organisms as toxicology screening tools has been significantly hampered, however, by the lack of convenient screening mechanisms or endpoints, such as those available in yeast or bacterial systems. Additionally, previous attempts to produce toxicology prediction systems have failed to provide the necessary modeling data and statistical information to accurately predict toxic responses (e.g., WO 00/12760, WO 00/47761, WO 00/63435, WO 01/32928, and WO 01/38579).
SUMMARY OF THE INVENTION
The present invention is based on the elucidation of the global changes in gene expression in renal tissues or cells exposed to known toxins, in particular renal toxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure.
In various aspects, the invention includes methods of predicting at least one toxic effect of a compound, predicting the progression of a toxic effect of a compound, and predicting the renal toxicity of a compound. The invention also includes methods of identifying agents that modulate the onset or progression of a toxic response. Also provided are methods of predicting the cellular pathways that a compound modulates in a cell. The invention also includes methods of identifying agents that modulate protein activities.
In a further aspect, the invention includes probes comprising sequences that specifically hybridize to genes in Tables 1-5. In some instances, the genes are rat genes. Also included are solid supports comprising at least two of the previously mentioned probes. The invention also includes a computer system that has a database containing information identifying the expression level in a tissue or cell sample exposed to a renal toxin of a set of genes comprising at least two genes in Tables 1-5.


DETAILED DESCRIPTION
Many biological functions are accomplished by altering the expression of various genes through transcriptional (e.g. through control of initiation, provision of RNA precursors, RNA processing, etc.) and/or translational control. For example, fundamental biological processes such as cell cycle, cell differentiation and cell death, are often characterized by the variations in the expression levels of groups of genes.
Changes in gene expression are also associated with the effects of various chemicals, drugs, toxins, pharmaceutical agents and pollutants on an organism or cell. For example, the lack of sufficient expression of functional tumor suppressor genes and/or the over expression of oncogene/protooncogenes after exposure to an agent could lead to tumorgenesis or hyperplastic growth of cells (Marshall (1991), Cell 64:313-326; Weinberg (1991), Science 254:1138-1146). Thus, changes in the expression levels of particular genes (e.g. oncogenes or tumor suppressors) may serve as signposts for the presence and progression of toxicity or other cellular responses to exposure to a particular compound.
Monitoring changes in gene expression may also provide certain advantages during drug screening and development. Often drugs are screened for the ability to interact with a major target without regard to other effects the drugs have on cells. These cellular effects may cause toxicity in the whole animal, which prevents the development and clinical use of the potential drug.
The present inventors have examined tissue from animals exposed to known renal toxins which induce detrimental kidney effects, to identify global changes in gene expression induced by these compounds. These global changes in gene expression, which can be detected by the production of expression profiles (an expression level of one or more genes), provide useful toxicity markers that can be used to monitor toxicity and/or toxicity progression by a test compound. Some of these markers may also be used to monitor or detect various disease or physiological states, disease progression, drug efficacy, and drug metabolism.
Identification of Toxicity Markers
To evaluate and identify gene expression changes that are predictive of toxicity, studies using selected compounds with well characterized toxicity have been conducted by the present inventors to catalogue altered gene expression. In the present study, indomethacin, diflunisal, colchicine, chloroform, diclofenac, menadione, sodium chromate, sodium oxalate, thioacetamide, and vancomycin were selected as known renal toxins.
Cephaloridine is an amphoteric, semi-synthetic, broad-spectrum cephalosporin derived from cephalosporin C. Cephalosporins are 3-lactam-containing antibiotics which prevent bacterial growth by inhibiting polymerization of the peptidoglycan bacterial cell wall. The linear glycan chains (composed of N-acetylglucosime and N-acetylmuramic acid) are cross-linked to each other by the coupling of short chains of several amino acids, the coupling resulting from the action of a transpeptidase. It is believed that cephalosporins act by blocking the activity of the transpeptidase ( Goodman & Gilman's The Pharmalogical Basis of Therapeutics 9 th ed ., J. G. Hardman et al. Eds., McGraw Hill, New York, 1996, pp. 1074-1075, 1089-1095).
Cephaloridine is administered intramuscularly and is used to treat infections of the respiratory tract, gastrointestinal tract and urinary tract, as well as infections of soft tissue, bones and joints. Noted adverse effects include hypersensitivity reactions (such as anaphylactic shock, urticaria and bronchospasm), gastrointestinal disturbances, candidiasis, and cardiovascular and blood toxicity, in particular, toxicity to the hematopoietic system (cells responsible for the formation of red and white blood cells and platelets).
Although cephaloridine may be nephrotoxic at high dosages, it is not as harmful to the kidneys as are the aminoglycosides and polymixins. High dosages of cephaloridine may cause acute renal tubular necrosis ( Cecil Textbook of Medicine 20 th ed., part XII , p. 586, J. C. Bennett and F. Plum Eds., W. B. Saunders Co., Philadelphia, 1996) or drug-induced interstitial nephritis, which is accompanied by elevated IgE levels, fever, arthralgia and maculopapular rash. Renal biopsy demonstrates edema and interstitial inflammatory lesions, mainly with lymphocytes, monocytes, eosinophils and plasma cells. Vasculitis of small vessels may develop, leading to necrotising glomerulonephritis (G. Koren, “The nephrotoxic potential of drugs and chemicals. Pharmacological basis and clinical relevance.,” Med Toxicol Adverse Drug Exp 4(1):59-72, 1989).
Cephaloridine has also been shown to reduce mitochondrial respiration and uptake of anionic succinate and carrier-mediated anionic substrate transport (Tune et al. (1990), J Pharmacol Exp Ther 252:65-69). In a study of oxidative stress and damage to kidney tissue, cephaloridine depleted reduced glutathione (GSH) and produced oxidized glutathione (GSSG) in the renal cortex. This drug also inhibited glutathione reductase and produced malondialdehyde and conjugated dienes (Tune et al. (1989), Biochem Pharmacol 38:795-802). Because cephaloridine is actively transported into the proximal renal tubule, but slowly transported across the lumenal membrane into the tubular fluid, high concentrations can accumulate and cause necrosis. Necrosis can be prevented by administering inhibitors of organic anion transport, although such treatment may be counterproductive, as cephaloridine is passed in and out of the kidney by the renal organic anion transport system (Tune et al. (1980), J Pharmacol Exp Ther 215:186-190).
Cisplatin (Pt (NH 3 ) 2 (Cl) 2 ), a broad-spectrum anti-tumor agent, is commonly used to treat tumors of the testicles, ovaries, bladder, skin, head and neck, and lungs (PDR 47 th ed., pp. 754-757, Medical Economics Co., Inc., Montvale, N.J., 1993 ; Goodman & Gilman's The Pharmalogical Basis of Therapeutics 9 th ed ., pp. 1269-1271, J. G. Hardman et al. Eds., McGraw Hill, New York, 1996). Cisplatin diffuses into cells and functions mainly by alkylating the N 7 of guanine, a highly reactive site, causing interstrand and intrastrand crosslinks in the DNA that are lethal to cells. The drug is not sensitive to the cell cycle, although its effects are most pronounced in S phase.
Because the drug is cleared from the body mainly by the kidneys, the most frequent adverse effect of cisplatin usage is nephrotoxicity, the severity of which increases with increasing dosage and treatment terms. Other adverse effects include renal tubule damage, myelosuppression (reduced numbers of circulating platelets, leukocytes and erythrocytes), nausea and vomiting, ototoxicity, serum electrolyte disturbances (decreased concentrations of magnesium, calcium, sodium, potassium and phosphate, probably resulting from renal tubule damage), increased serum concentrations of urea and creatinine, and peripheral neuropathies.
In one study on rats (Nonclercq et al. (1989), Exp Mol Pathol 51:123-140) administration of cisplatin or carboplatin induced renal injury, carboplatin causing less damage than cisplatin. The most prominent injury was to the straight portion of proximal renal tubule.
In another rat study (Goldstein et al. (1981), Toxicol Appl Pharmacol 60:163-175) animals injected with cisplatin displayed decreased food intake as drug dosage increased. On day 2, the high-dose groups (10-15 mg/kg) exhibited a six or seven-fold elevation in BUN. On day 4, BUN elevation was noted in the 5 mg/kg group. An increase in urine volume was observed beginning on days 3-4, along with decreased urine osmolality in the low-dose groups (2.5 or 5 mg/kg). Another experiment on rats (Agarwal et al. (1995), Kidney Int 48:1298-1307) showed that cisplatin treatment produced elevations in serum creatinine levels, which began on day 3 and progressed for the duration of the study.
PAN (C 22 H 29 N 7 O 5 ), an antibiotic produced by Streptomyces alboniger , inhibits protein synthesis and is commonly used experimentally on rats to mimic human minimal change disease. One study showed that PAN-injected rats demonstrated an increase in levels of serum non-esterified fatty acids, while the serum albumin concentration was negatively affected (Sasaki et al. (1999), Adv Exp Med Biol 467:341-346).
In another rat study, an adenosine deaminase inhibitor prevented PAN nephrotoxicity, indicating that PAN toxicity is linked to adenosine metabolism (Nosaka et al. (1997), Free Radic Biol Med 22:597-605). Another group showed that PAN, when administered to rats, led to proteinuria, a condition associated with abnormal amounts of protein in the urine, and renal damage, e.g. blebbing of glomerular epithelial cells, focal separation of cells from the glomerular basement membrane, and fusion of podocytes (Olson et al. (1981), Lab Invest 44:271-279). In another study on rats, administration of PAN induced glomerular epithelial cell apoptosis in a dose- and time-dependent manner (Sanwal et al. (2001), Exp Mol Pathol 70:54-64).
One study with PAN-injected rats (Koukouritaki et al. (1998), J Investig Med 46: 284-289) examined the changes in the expression of the proteins paxillin, focal adhesion kinase, and Rho, all of which regulate cell adhesion to the extracellular matrix. Paxillin levels increased steadily, peaked at day 9 after PAN injection, and then remained elevated even after proteinuria resolved. There was no observed change in expression of either focal adhesion kinase or Rho.
BEA, (C 2 H 6 BrN.HBr), is commonly used experimentally on rats to induce papillary necrosis and renal cortex damage, which is similar to human analgesic nephropathy. BEA-induced papillary necrosis in rats eventually leads to the onset of focal glomerular sclerosis and nephrotic proteinuria (Garber et al. (1999), Am J Kidney Dis 33: 1033-1039). Even at low doses (50 mg/kg), BEA can induce an apex limited renal papillary necrosis (Bach et al. (1983), Toxicol Appl Pharmacol 69:333-344). In male Wistar rats, BEA administered at 100 mg/kg was shown to cause renal papillary necrosis within 24 hours (Bach et al. (1991), Food Chem Toxicol 29:211-219). Additionally, Bach et al. showed that there was an increase in urinary triglycerides, and lipid deposits were seen by Oil Red O lipid staining in the cells of the collecting ducts and hyperplastic urothelia adjacent to the necrosed region.
It has also been shown that succinate and citrate concentrations are significantly lower in the urine of BEA-treated rats (Holmes et al. (1995), Arch Toxicol 70:89-95). Moreover, BEA treatment induced glutaric and adipic aciduria, which is symptomatic of an enzyme deficiency in the acyl CoA dehydrogenases. The same study examined urinary taurine levels in desert mice, and in BEA-treated desert mice there was an increase in the urinary taurine level which is indicative of liver toxicity.
Another study on BEA-treated rats showed that there was an increase in the concentrations of creatine in the renal papilla and glutaric acid in the liver, renal cortex, and renal medulla as soon as 6 hours post-treatment (Garrod et al. (2001), Magn Reson Med 45: 781-790).
Discovered and purified in the early 1960's, gentamicin is a broad-spectrum aminoglycoside antibiotic that is cidal to aerobic gram-negative bacteria and commonly used to treat infections, e.g., those of the urinary tract, lungs and meninges. As is typical for an aminoglycoside, the compound is made of two amino sugar rings linked to a central aminocyclitol ring by glycosidic bonds. Aminoglycosides are absorbed poorly with oral administration, but are excreted rapidly by the kidneys. As a result, kidney toxicity is the main adverse effect, although ototoxicity and neuromuscular blockade can also occur. Gentamicin acts by interfering with bacterial protein synthesis. This compound is more potent than most other antibacterial inhibitors of protein synthesis, which are merely bacteriostatic, and its effects on the body are, likewise, more severe ( Goodman & Gilman's The Pharmalogical Basis of Therapeutics 9 th ed ., pp. 1103-1115, J. G. Hardman et al. Eds., McGraw Hill, New York, 1996).
Aminoglycosides work rapidly, and the rate of bacterial killing is concentration-dependent. Residual bactericidal activity remains after serum concentration has fallen below the minimum inhibitory concentration (MIC), with a duration that is also dosage/concentration-dependent. The residual activity allows for once-a-day administration in some patients. These drugs diffuse into bacterial cells through porin channels in the outer membrane and are then transported across the cytoplasmic membrane via a membrane potential that is negative on the inside (Goodman & Gilman, supra).
Kidney damage, which can develop into renal failure, is due to the attack of gentamicin on the proximal convoluted tubule, particularly in the S1 and S2 segments. The necrosis, however, is often patchy and focal (Shanley et al. (1990), Ren Fail 12:83-87). A rat study by Shanley et al. showed that superficial nephrons are more susceptible to necrosis than juxtamedullary nephrons, although the initial segment of the superficial nephrons is remarkably resistant to necrosis.
Reported enzymatic changes upon gentamicin treatment are increased activities of N-acetyl-beta-D-glucosaminidase and alkaline phosphatase and decreased activities of sphingomyelinase, cathepsin B, Na + /K + -ATPase, lactate dehydrogenase and NADPH cytochrome C reductase, along with decreased protein synthesis and alpha-methylglucose transport (Monteil et al. (1993), Ren Fail 15:475-483). An increase in gamma-glutamyl transpeptidase activity in urine has also been reported (Kocaoglu et al. (1994), Arch Immunol Ther Exp ( Warsz ) 42:125-127), and the quantification of this enzyme in urine is a useful marker for monitoring gentamicin toxicity.
One source of renal pathology resulting from gentamicin treatment is the generation of reactive oxygen metabolites. Gentamicin has been shown, both in vitro and in vivo, to be capable of enhancing the production of reactive oxygen species. Iron, a necessary co-factor that catalyzes free-radical formation, is supplied by cytochrome P450 (Baliga et al. (1999), Drug Metab Rev 31:971-997).
A gene delivery experiment in rats, in which the human kallikrein gene was cloned into an adenovirus vector and the construct then co-administered with a gentamicin preparation, showed that kallikrein can protect against gentamicin-induced nephrotoxicity. Significantly increased renal blood flow, glomerular filtration rates and urine flow were observed, along with decreased renal tubular damage, cellular necrosis and lumenal protein casts. Kallikrein gene delivery also caused a decrease in blood urea nitrogen levels and increases in urinary kinin and nitrite/nitrate levels. This study provides evidence that the tissue kallikrein-kinin system may be a key pathway that is perturbed during the induction of nephrotoxicity by gentamicin (Murakami et al. (1998), Kidney Int 53:1305-1313).
Ifosfamide, an alkylating agent, is commonly used in chemotherapy to treat testicular, cervical, and lung cancer. Ifosfamide is slowly activated in the liver by hydroxylation, forming the triazene derivative 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed., p. 1235, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). Cytochrome P450 activates DTIC via an N-demethylation reaction yielding an alkylating moiety, diazomethane. The active metabolites are then able to cross-link DNA causing growth arrest and cell death. Though ifosfamide is therapeutically useful, it is also associated with nephrotoxicity, urotoxicity, and central neurotoxicity.
Mesna, another therapeutic, is often administered concomitantly to prevent kidney and bladder problems from arising (Brock and Pohl (1986), IARC Sci Publ 78:269-279). However, there are documented cases in which tubular toxicity occurred and elevated urinary levels of alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase were found in patients even though mesna was administered alongside ifosfamide (Goren et al. (1987), Cancer Treat Rep 71:127-130).
One study examined 42 patients that had been administered ifosfamide to treat advanced soft-tissue sarcoma (Stuart-Harris et al. (1983), Cancer Chemother Pharmacol 11:69-72). The ifosfamide dosage varied from 5.0 g/m 2 to 8.0 g/m 2 , and all of the patients were given mesna to counteract the negative effects of ifosfamide. Even so, nausea and vomiting were common to all of the patients. Out of the 42 patients, seven developed nephrotoxicity, and two of the cases progressed to fatal renal failure.
In another clinical study, renal tubular function was monitored in 18 neuroblastoma patients (Caron et al. (1992), Med Pediatr Oncol 20:42-47). Tubular toxicity occurred in at least 12 of the patients, and seven of those patients eventually developed Debre-de Toni-Fanconi syndrome, although in 3 cases the syndrome was reversible.
Fanconi syndrome is a disorder marked by dysfunction of the proximal tubules of the kidney. It is associated with aminoaciduria, renal glycosuria, and hyperphosphaturia. Ifosfamide is often used experimentally on rats to induce Fanconi syndrome. In one study, rats that were administered 80 mg/kg of ifosfamide had significantly lower body weight and hematocrit than control rats (Springate and Van Liew (1995), J Appl Toxicol 15:399-402). Additionally, the rats had low-grade glucosuria, proteinuria, and phosphaturia. In a mouse study, ifosfamide induced elevated serum creatinine and urea levels and decreased the clearance rate of creatinine (Badary (1999), J Ethnopharmacol 67:135-142).
Cyclophosphamide, a nitrogen mustard and alkylating agent, is highly toxic to dividing cells and is commonly used in chemotherapy to treat malignant lymphomas, such as non-Hodgkin's lymphomas and Burkitt's lymphoma, multiple myeloma, leukemias, neuroblastomas, ovarian adenocarcinomas and retinoblastomas, as well as breast and lung cancer ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., pp. 1234, 1237-1239, J. G. Hardman et al., eds., McGraw Hill, New York, 1996; Physicians Desk Reference, 47 th ed., pp. 744-745, Medical Economics Co., Inc., Montvale, N.J., 1993). Additionally, cyclophosphamide is used as an immunosuppressive agent in bone marrow transplantation and following organ transplantation. Although cyclophosphamide is therapeutically useful against certain types of cancer, it is also associated with cardiotoxicity, nephrotoxicity (including renal tubular necrosis), hemorrhagic cystitis, myelosuppression, hepatotoxicity, impairment of male and female reproductive systems, interstitial pneumonitis and central nervous system toxicity.
Once in the liver, cyclophosphamide is hydroxylated by the cytochrome P450 mixed function oxidase system, producing the active metabolites phosphoramide mustard and acrolein, which cross-link DNA and cause growth arrest and cell death. These metabolites, however, are highly toxic and cause adverse effects in the other organs into which they are transported, such as the kidneys. Acrolein is removed from the kidneys by secretion into the urine, resulting in cystitis (inflammation of the bladder), often hemorrhagic cystitis.
In the kidney, cyclophosphamide induces necrosis of the renal distal tubule. Cyclophosphamide, which is structurally similar to the anti-cancer drug ifosfamide, does not induce damage to the renal proximal tubule nor does it induce Debre-de Toni-Fanconi syndrome (Rossi et al. (1997), Nephrol Dial Transplant 12:1091-1092).
One clinical trial of patients being treated with cyclophosphamide showed that renal damage from the drug leads to a reduced biotransformation rate and low renal clearance of the drug, resulting in a build-up of toxic alkylating metabolic products (Wagner et al. (1980), Arzneimittelforschung 30:1588-1592).
In a study of patients suffering from malignant lymphomas and mammary carcinomas, a direct relationship was found between the dose of cyclophosphamide used in treatment and the concentration of alkylating metabolites in the patients' urine. The upper limit of the dose was determined by the nature and degree of the toxic side effects, rather than by the rate at which the drug could be metabolized (Saul et al. (1979), J Cancer Res Clin Oncol 94:277-286). It is the acrolein itself that is toxic, not the alkylating activity of cyclophosphamide (Brock et al. (1979), Arzneimittelforschung 29:659-661). A study on rats also showed that acrolein from the kidneys can produce hemorrhagic cystitis and that the acrolein concentration is directly related to the frequency and severity of the cystitis (Chijiwa et al. (1983), Cancer Res 43:5205-5209).
Carboplatin, a platinum coordination complex, is commonly used in chemotherapy as an anti-tumor agent. As a chemotherapeutic agent, carboplatin acts similarly to cisplatin. Carboplatin enters the cell by diffusion where it is activated by hydrolysis ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., p. 1270-1271, J. G. Hardman et al. Eds., McGraw Hill, New York 1996). Once activated, the platinum complexes are able to react with DNA causing cross-linking to occur. One of the differences between carboplatin and cisplatin is that carboplatin is better tolerated clinically. Some of the side-effects associated with cisplatin, such as nausea, neurotoxicity, and nephrotoxicity, are seen at a lesser degree in patients administered carboplatin. Some other side-effects are hypomagnesaemia and hypokalaemia (Kintzel (2001), Drug Saf 24:19-38).
In one study on male Wistar rats, carboplatin was administered at a dosage of 65 mg/kg (Wolfgang et al. (1994), Fundam Appl Toxicol 22:73-79). After treatment with carboplatin, CGT excretion was increased approximately two-fold.
Another study compared cisplatin and carboplatin when given in combination with vindesine and mitomycin C (Jelic et al. (2001) Lung Cancer 34:1-13). The study showed that carboplatin administered with vindesine and mitomycin C was advantageous in terms of overall survival, although the regimen was more hematologically toxic than when cisplatin was given.
AY-25329, is a phenothiazine that has been shown to be mildly hepatotoxic and to induce nephrosis. Its structure is shown below.


Phenothiazines are a class of psychoactive drugs. They have been used to treat schizophrenia, paranoia, mania, hyperactivity in children, some forms of senility, and anxiety (http://www.encyclopedia.com/articlesnew/36591.html). Some side effects associated with prolonged use of the drugs are reduced blood pressure, Parkinsonism, reduction of motor activity, and visual impairment.
Chlorpromazine (Thorazine or Largactil) is an aliphatic phenothiazine and is widely used for treating schizophrenia and manic depression. Prolactin secretion is increased while taking chlorpromazine, and galactorrhea and gynecomastia have both been associated with the drug (http://www.mentalhealth.com/drug/p30-c01.html). Trifluoperazine is another prescribed phenothiazine. It is used to treat anxiety, to prevent nausea and vomiting, and to manage psychotic disorders (http://www.mentalhealth.com/drug/p30-s04.html). Negative side-effects that have been associated with the drug are liver damage, bone marrow depression, and Parkinsonism.
Acyclovir (9-[(2-hydroxyethyl)methyl]guanine, Zovirax®), an anti-viral guanosine analogue, is used to treat herpes simplex virus (HSV), varicella zoster virus (VZV) and Epstein-Barr virus (EBV) infections. It is transported into cells by the nucleoside transporter that imports guanine, and acyclovir is phosphorylated by virally encoded thymidine kinase (TK). Other kinases convert acyclovir to its activated di- and triphosphate forms, which prevent the polymerization of viral DNA. Acyclovir triphosphate competes with dGTP for the viral polymerase, and acyclovir is preferentially incorporated, but as a monophosphate. As a result, chain elongation ceases ( Fields Virology 3 d ed ., Fields et al., eds., pp. 436-440, Lippincott-Raven Publishers, Philadelphia, 1996; Cecil Textbook of Medicine 20 th ed ., part XII, p. 1742, J. C. Bennett and F. Plum Eds., W. B. Saunders Co., Philadelphia, 1996).
The pharmacokinetics of acyclovir show that it has a useful half-life of about three hours and that most of it is excreted in the urine largely unchanged (Brigden et al. (1985), Scand J Infect Dis Suppl 47:33-39). Not surprisingly, the most frequent adverse effect of acyclovir treatment is damage to various parts of the kidney, particularly the renal tubules. Crystalluria, or the precipitation of crystals (in this case, crystals of acyclovir), in the lumina of the renal tubules can occur (Fogazzi (1996), Nephrol Dial Transplant 11:379-387). If the drug crystallizes in the renal collecting tubules, obstructive nephropathy and tubular necrosis can result (Richardson (2000), Vet Hum Toxicol 42:370-371). Tissues from biopsies of affected patients showed dilation of the proximal and distal renal tubules, with loss of the brush border, flattening of the lining cells and focal nuclear loss (Becker et al. (1993), Am J Kidney Dis 22:611-615).
Citrinin, a mycotoxin produced by the fungus Penicillium citrinum , is a natural contaminant of foods and feeds (Bondy and Armstrong (1998) Cell Biol. Toxicol. 14:323-332). It is known that mycotoxins can have negative effects on the immune system, however citrinin-treated animals have been shown to stimulate responses against antigens (Sharma (1993) J. Dairy Sci. 76:892-897). Citrinin is a known nephrotoxin, and in birds such as chickens, ducklings, and turkeys, it causes diarrhea, increased food consumption and reduced weight gain due to kidney degeneration (Mehdi et al. (1981) Food Cosmet. Toxicol. 19:723-733; Mehdi et al. (1984) Vet. Pathol. 21:216-223). In the turkey and duckling study, both species exhibited nephrosis with the occurrence of hepatic and lymphoid lesions (Mehdi et al., 1984).
In one study, citrinin was administered to rabbits as a single oral dose of either 120 or 67 mg/kg (Hanika et al. (1986) Vet. Pathol. 23:245-253). Rabbits treated with citrinin exhibited renal alterations such as condensed and distorted mitochondria, distended intercellular spaces of the medullary and straight cortical distal tubules, and disorganization of interdigitating processes. In another rabbit study, citrinin-administered rabbits displayed azotaemia and metabolic acidosis (Hanika et al. (1984) Food Chem. Toxicol. 22:999-1008). Renal failure was indicated by decreased creatinine clearance and increased blood urea nitrogen and serum-creatinine levels.
In the past, mercury was an important component of pharmaceuticals, particularly of antiseptics, antibacterials, skin ointments, diuretics and laxatives. Although, mercury has been largely replaced by more effective, more specific and safer compounds, making drug-induced mercury poisoning rare, it is still widely used in industry. Poisoning from occupational exposure and environmental pollution, such as mercury release into public water supplies, remains a concern as wildlife, domestic animals and humans are affected.
Because of their lipid solubility and ability to cross the blood-brain barrier, the most dangerous form of mercury is the organomercurials, the most common of which is methylmercury, a fungicide used for disinfecting crop seeds. In a number of countries, incidents involving large-scale illness and death from mercury poisoning have been reported when mercury-contaminated seeds were planted and the crops harvested and consumed. A second source of organic mercury poisoning results from industrial chemicals containing inorganic mercury, such as mercury catalysts, which form methylmercury as a reaction product. If this waste product is released into reservoirs, lakes, rivers or bays, the surrounding population can become sick or die, particularly those who eat local fish.
The inorganic salt mercuric chloride, HgCl 2 , as well as other mercuric salts, are more irritating and more toxic than the mercurous forms. Mercuric chloride is used today in industry, for the manufacture of bleach, electronics, plastics, fungicides and dental amalgams. The main source of human exposure is industrial dumping into rivers (Goodman & Gilman's: The Pharmacological Basis of Therapeutics (9th ed.), pp. 1654-1659, McGraw-Hill, New York, 1996).
When inorganic mercury salts are ingested, about 10% of the mercuric ions are absorbed by the gastrointenstinal tract, and a considerable portion of the Hg 2+ can remain bound to the mucosal surfaces. The highest concentration of Hg 2+ is found in the kidneys, as it is retained there longer than in other tissues. Consequently, the kidneys are the organ most adversely affected by inorganic mercury poisoning. The proximal tubules are the major site of damage, where tubular necrosis results. The mercury affects primarily the S2 and S3 portions of the proximal tubules, but, at high levels of mercury exposure, the S1 and distal portions of the tubules are also damaged. These regions of the nephrons are affected because they contain enzymes (such as gamma-glutamyltranspeptidase) and transport proteins (such as the basolateral organic anion transport system) involved in mercury uptake (Diamond et al. (1998), Toxicol Pathol 26:92-103).
Urinary markers of mercury toxicity which can be detected in NMR spectra include elevated levels of lactate, acetate and taurine and decreased levels of hippurate (Holmes et al. (2000), Chem Res Toxicol 13:471-478). Known changes in gene expression in kidneys exposed to Hg 2+ include up-regulation of the heat-shock protein hsp72 and of the glucose-regulated protein grp94. The degree of tissue necrosis and level of expression of these proteins is proportional to both the dose of mercury (Hg 2+ ) and the length of the exposure time to mercury (Hg 2+ ), with hsp72 accumulating in the renal cortex and grp94 accumulating in the renal medulla (Goering et al. (2000), Toxicol Sci 53:447-457).
Indomethacin is a non-steroidal antiinflammatory, antipyretic and analgesic drug commonly used to treat diseases such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and gout. This drug acts as a potent inhibitor of prostaglandin synthesis; it inhibits the cyclooxygenase enzyme necessary for the conversion of arachidonic acid to prostaglandins ( PDR 47 th ed ., Medical Economics Co., Inc., Montvale, N.J., 1993; Goodman & Gilman's The Pharmalogical Basis of Therapeutics 9 th ed ., J. G. Hardman et al., Eds., McGraw Hill, New York, 1996, pp. 1074-1075, 1089-1095 ; Cecil Textbook of Medicine, 20th ed., part XII, pp. 772-773, 805-808, J. C. Bennett and F. Plum Eds., W. B. Saunders Co., Philadelphia, 1996).
The most frequent adverse effects of indomethacin treatment are gastrointestinal disturbances, e.g., bleeding, ulcers and perforations, although renal toxicity can also result, particularly after long-term administration. In rats, hemorrhage and necrosis have been observed in the renal papillae and fornix, as well as damage to the thick ascending limbs (mTALs), and interstitial nephritis with hematuria, proteinuria and nephrotic syndrome have been reported in humans. Patients suffering from renal dysfunction risk developing a reduction in renal blood flow and urinary outflow, because renal prostaglandins play an important role in renal perfusion and glomerular filtration (Heyman et al. (1997), Kidney Int 51: 653-663).
Diflunisal, a non-steroidal anti-inflammatory drug (NSAID), is a difluorophenyl derivative of salicylic acid ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., p. 631, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). It is most frequently used in the treatment of osteoarthritis and musculoskeletal strains. NSAIDs have analgesic, antipyretic and anti-inflammatory actions, however hepatotoxicity is known to be an adverse side effect of NSAID treatment (Masubuchi et al. (1998) J. Pharmacol. Exp. Ther. 287:208-213). Diflunisal has been shown to be less toxic than other NSAIDs, nevertheless over long periods of dosage it can lead to deleterious effects on platelet or kidney function (Bergamo et al. (1989) Am. J. Nephrol. 9:460-463). Other side effects that have been associated with diflunisal treatment are diarrhea, dizziness, drowsiness, gas or heartburn, headache, nausea, vomiting, and insomnia (http://arthritisinsight.com/medical/meds/dolobid.html).
Masubuchi et al. compared the hepatotoxicity of 18 acidic NSAIDs. In the study, diflunisal (administered at a concentration of 500 μM) was shown to increase LDH leakage in rat hepatocytes, a marker for cell injury, when compared to the control sample. In addition, treatment with diflunisal led to decreased intracellular ATP concentrations.
One study compared the effects of diflunisal and ibuprofen when given to patients over a two week period (Muncie and Nasrallah (1989) Clin. Ther. 11:539-544). In both the ibuprofen and the diflunisal group, two patients complained of abdominal cramping. The study indicated that even during short-term usage some gastrointestinal effects may occur. The toxic dose used in this study was chosen as one that did not induce significant gastric ulceration in rats. The group of rats given the high dosage of diflunisal had increased concentrations of creatinine which is consistent with renal injury, although dehydration may also cause increases in creatinine concentration.
Cidofovir (Vistide®) is an antiviral cytosine analog used in the treatment of viral infections such as herpesvirus, adenovirus, papillomavirus, poxvirus and hepadnavirus ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., p. 1216, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). It is also useful for the treatment of cytomegalovirus (CMV) infection, which is a type of herpesvirus.
Some mild side effects seen in patients receiving cidofovir are nausea, vomiting, and fever. The most serious reported side effect of the drug is kidney toxicity (http://tthivclinic.com/cido.html). In response to the threat of nephrotoxicity, it is necessary for patients receiving cidofovir to have their kidneys checked before treatment, and the patients must be monitored during treatment for early symptoms of kidney problems. In addition, cidofovir is given with fluids to help reduce the risk of kidney toxicity (http://www.aidsinfonyc.org/network/simple/cido.html). Probenecid, a drug that helps protect the kidneys, is normally administered concomitantly (Lalezari and Kuppermann (1997) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 14:S27-31).
One study compared the safety and efficacy of cidofovir in the treatment of CMV (Lalezari et al. (1998) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 17:339-344). Approximately 40% of the patients exhibited dose-dependent asymptomatic proteinuria and 25% of the patients had elevated serum creatinine levels.
Pamidronate (Aredia®) is a bisphosphonate drug that is clinically used to inhibit bone resorption and make bones more stable. It is used to treat hypercalcemia (too much calcium in the blood) that occurs with some types of cancer. Typically administered by intravenous injection, pamidronate is frequently used in patients with breast cancer or multiple myeloma whose disease has spread to the bones. Some side effects related to pamidronate treatment are abdominal cramps, chills, confusion, fever, muscle spasms, nausea, muscle stiffness, and swelling at the injection site (http://www.nursing.uiowa.edu/sites/PedsPain/Adjuvants/PAMIDRnt.html). Patients with kidney problems may be prohibited from using pamidronate as it is excreted through the kidneys.
In one study, rats and mice were given varying doses of labeled pamidronate (Cal and Daley-Yates (1990) Toxicology 65:179-197). Pamidronate treatment led to significant weight loss and a decrease in creatinine clearance. Morphological studies showed a loss of brush border membranes and the presence of focal proximal tubular necrosis.
Another study compared the tolerability of different treatments for hypercalcemia of malignancy by reviewing articles published between 1979 and 1998 (Zojer et al. (1999) Drug Saf 21:389-406). The authors found that elevated serum creatinine level, nausea, and fever were reported following treatment with bisphosphonates such as pamidronate.
Markowitz et al. (2001, J. Am. Soc. Nephrol. 12:1164-1172) tried to determine whether there was a correlation between pamidronate treatment and collapsing focal segmental glomerulosclerosis (FSGS). The authors examined the histories of seven patients who had developed collapsing FSGS, and they found that the only drug treatment in common was the administration of pamidronate. When given at the recommended dose of 90 mg per month, renal toxicity was rare. However, when pamidronate was given at higher doses nephrotoxicity occurred.
Lithium, an alkali metal, is the main pharmacological treatment for bipolar disorders. It is typically given as a salt, such as lithium carbonate or lithium citrate. Some common side effects of lithium treatment are an increase in urination, increase in drinking, dry mouth, weight gain, fine tremor, and fatigue. Some more serious side effects related to lithium treatment are blurred vision, mental confusion, seizures, vomiting, diarrhea, muscle weakness, drowsiness, and coarse tremor ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., p. 448, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996).
Since lithium is often used on a maintenance basis for a lifelong period, numerous studies have been performed to try and elucidate the effects of lithium on the kidney. One group administered lithium in daily doses within the human therapeutic range to male Wistar rats (Kling et al. (1984) Lab Invest 50:526-535). Rats that were given lithium developed marked polyuria within three weeks of the initial dosing. The rats displayed elevated free water clearance and vasopressin-resistant diabetes insipidus. The cortical collecting tubules displayed morphological changes, e.g. dilation of the tubules, bulging cells lining the tubules, enlarged nuclei, following lithium treatment.
Another study examined a human population that had been given lithium for the treatment of bipolar disorder (Markowitz et al. (2000) J. Am. Soc. Nephrol. 11:1439-1448). The patients had a mean age of 42.5 years and had been undergoing lithium treatment from 2 to 25 years (mean of 13.6 years). Approximately one fourth of the patients had nephrotic proteinuria, almost 90% of them had nephrogenic diabetes insipidus (NDI), and renal biopsies revealed a chronic tubulointerstitial nephropathy in all of the patients. Following cessation of lithium treatment, seven of the patients proceeded to end-stage renal disease.
Even though nephrotoxicity is a known side effect of lithium treatment, some studies have indicated that in actuality it is not all that common (Johnson (1998) Neuropsychopharmacology 19:200-205). One study showed that the NDI-like effect in lithium treatment was easily overcome by increasing the levels of arginine vasopressin (AVP) (Carney et al. (1996) Kidney Int 50:377-383). Other studies have suggested that patients with psychiatric disorders display certain defects in renal function without undergoing lithium treatment (Gitlin (1999) Drug Saf 20:231-243).
Hydralazine, an antihypertensive drug, causes relaxation of arteriolar smooth muscle. Such vasodilation is linked to vigorous stimulation of the sympathetic nervous system, which in turn leads to increased heart rate and contractility, increased plasma renin activity, and fluid retention ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., p. 794, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). The increased renin activity leads to an increase in angiotensin II, which in turn causes stimulation of aldosterone and sodium reabsorption.
Hydralazine is used for the treatment of high blood pressure (hypertension) and for the treatment of pregnant women suffering from high blood pressure (pre-eclampsia or eclampsia). Some common side effects associated with hydralazine use are diarrhea, rapid heartbeat, headache, decreased appetite, and nausea. Hydralazine is often used concomitantly with drugs that inhibit sympathetic activity to combat the mild pulmonary hypertension that can be associated with hydralazine usage.
In one hydralazine study, rats were fed hydralazine and mineral metabolism was monitored (Peters et al. (1988) Toxicol Lett 41:193-202). Manganese and zinc concentrations were not effected by hydralazine treatment, however tissue iron concentrations were decreased and kidney copper concentrations were increased compared to control groups.
Another study compared the effects of hydrazine, pheneizine, and hydralazine treatment on rats (Runge-Morris et al. (1996) Drug Metab Dispos 24:734-737). Hydralazine caused an increase in renal GST-alpha subunit expression, although unlike hydrazine and pheneizine it did not alter renal cytochrome P4502E1 expression.
Colchicine, an alkoloid of Colchicum autumale , is an antiinflammatory agent used in the treatment of gouty arthritis ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., p. 647, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996).
An antimitotic agent, colchicine binds to tubulin which leads to depolymerization and disappearance of the fibrillar microtubules in granulocytes and other motile cells. In doing so, the migration of granulocytes into the inflamed area is inhibited. Through a series of events, the inflammatory response is blocked.
Some common, mild side effects associated with colchicine treatment are loss of appetite and hair loss. More severe side effects that warrant cessation of treatment are nausea, vomiting, diarrhea, and abdominal pain. Colchicine overdose can induce multiorgan failure with a high incidence of mortality. In this setting, renal failure is multifactorial and related to prolonged hypotension, hypoxemia, sepsis, and rhabdomyolysis. In rats, less dramatic doses have been shown to inhibit the secretion of many endogenous proteins such as insulin and parathyroid hormone.
One study investigated the effects of colchicine on microtubule polymerization status and post-translational modifications of tubulin in rat seminiferous tubules (Correa and Miller (2001) Biol Reprod 64:1644-1652). Colchicine caused extensive microtubule depolymerization, and total tubulin levels decreased twofold after colchicine treatment. The authors also found that colchicine treatment led to a decrease in tyrosination of the microtubule pool of tubulin which was associated with depolymerization of microtubules.
Sulfadiazine, a sulfonamide, is an antimicrobial agent. It is commonly used concomitantly with pyrimethamine to treat toxoplasmosis, an infection of the brain, in patient suffering from AIDS. These drugs are able to cross the blood-brain barrier and are used at relatively high doses. In addition, sulfadiazine has been shown to be effective at preventing certain types of meningococcal diseases and in treating urinary tract infections.
Sulfonamides in general are structural analogs of para-aminobenzoic acid (PABA). Because they are competitive antagonists of PABA, sulfonamides are effective against bacteria that are required to utilize PABA for the synthesis of folic acid ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., p. 1058-1060, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996).
The main side effects associated with sulfadiazine treatment are fever and skin rashes. Decreases in white blood cells, red blood cells, and platelets, nausea, vomiting, and diarrhea are some other side effects that may result from sulfadiazine treatment. The most troublesome problem with this drug for HIV/AIDS patients is kidney toxicity. These patients tend to use these drugs for extended periods of time, which puts a constant strain on the kidneys. In addition, kidney stones tend to form in the bladder and ureter thereby blocking the flow of urine. Kidney damage may result, and if left untreated kidney failure may occur. Therefore, patients being treated with sulfadiazine are instructed to increase their fluid intake in order to prevent crystal formation in the kidneys.
One case study examined four HIV-positive patients who had been given sulfadiazine to treat toxoplasmosis (Crespo et al. (2000) Clin Nephrol 54:68-72). All four of the patients, one of whom was a previously healthy person, developed oliguria, abdominal pain, renal failure, and displayed multiple radiolucent renal calculi in echography. Following extensive hydration and alcalinization, the renal function of the patients returned to normal.
Adriamycin, known generically as doxorubicin, is an anthracycline antibiotic produced by the fungus Streptomyces peucetius . It is an anti-tumor drug used in the treatment of breast, ovarian, bladder, and lung cancers as well as non-Hodgkin's lymphoma, Hodgkin's disease and sarcoma ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th ed ., p. 1264-1265, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996).
Adriamycin has tetracycline ring structures with the sugar daunosamine attached by glycosidic linkage. It is able to intercalate with DNA, it affects DNA and RNA synthesis, and it can interact with cell membranes and alter their functions. Typically the drug is cell-cycle specific for the S phase of cell division. By binding to the cancer cells' DNA and blocking topoisomerase II, cancer cells are unable to divide and grow.
Some common side effects associated with adriamycin treatment are fatigue, a drop in white blood cell, red blood cell, or platelet count, hair loss, skin discoloration, and watery eyes (www.cancerhelp.org.uk/help/default.asp?page=4025). More serious side effects include myocardial toxicity, ulceration and necrosis of the colon, and development of a second cancer.
Because of its utility in fighting cancer, numerous studies have been performed in attempts to further understand the mechanisms and effects of adriamycin. In one study, investigators injected mice with a single dose of adriamycin (Chen et al. (1998) Nephron 78:440-452). The mice exhibited signs of combined glomerular albuminuria and immunoglublinuria, progressively elevated levels of nitrite/nitrate in the urine, abnormal renal function, and other symptoms indicative of focal segmental glomerulosclerosis.
In another study, rats were given adriamycin and the effects on angiotensin converting enzyme (ACE) were monitored (Venkatesan et al. (1993) Toxicology 85:137-148). The rats developed glomerular and tubular injury, and serum ACE levels were significantly elevated 20, 25, and 30 days post-treatment. A different study followed rabbits for up to one year that were treated with either adriamycin, nephrectomy, or combinations thereof (Gadeholt-Gothlin et al. (1995) Urol Res 23:169-173). The rabbits that were treated with adriamycin exhibited signs of nephrotoxicity at relatively low doses.
Menadione (vitamin K 3 ) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver. The primary known function of vitamin K is to assist in normal blood clotting, but it may also play a role in bone calcificaton. Menadione is a quinone compound that induces oxidative stress. It has been used as an anticancer agent and radiosensitizer and can produce toxicity in the kidney, lung, heart, and liver. In the kidney, signs of toxicity are dose-dependent, ranging from minor degranulation of tubular cells at lower doses to tubular dilatation, formation of protein casts in the renal tubules, calcium mineralization, vacuolization in the proximal and distal renal tubules, granular degeneration in the cortex and necrosis and apoptosis (Chiou et al., Toxicology (1997) 124(3):193-202).
Monocrotaline, an alkaloid obtained from Crotalaria spectabilis , a warm-climate garden plant, induces multi-organ toxicity affecting the kidney, heart, liver and lung. This compound is used to induce mesangiolysis in the kidney, to mimic the effects of Habu venom poisoning and hemolytic-uremic syndrome. Renal lesions in rats first appeared in the glomerular capillaries (endothelial cell detachment and adhesion of platelets to the basal lamina), followed by severe edema in the mesangium. Mesangiolysis subsequently occurred, accompanied by dilatation or obliteration of capillaries and necrosis and hemorrhage in the mesangium (Kurozumi et al., Exp Mol Pathol (1983) 39(3):377-386).
Vancomycin is a polycyclic glycoprotein antibiotic that is used to treat severe systemic infections by beta-lactam-resistant bacteria, in particular, resistant staphylococci. This drug may be given to patients who are allergic to penicillin. Vancomycin can induce renal failure and interstitial nephritis ( Physicians Desk Reference 56 th Ed ., pp. 1970-1971, Medical Economics Co., Montvale, N.J., 2002).
Sodium chromate, a model compound used to induce liver toxicity, also produces toxic effects in the kidney. Necrosis of the S1 segment of the proximal tubule has been reported, as well as acute renal failure, characterized by increased levels of kininogens in the renal cortex and medulla and in urine and decreased rates of glomerular filtration (Bompart et al., Nephron ( 1993) 65(4):612-618; Beckwith-Hall et al., Chem Res Toxicol ( 1998) 11(4):260-272).
In the kidney, sodium oxalate forms crystals in the urinary tract, resulting in tubular obstruction, and produces calcific kidney stones in humans and in rats. The stones are located on renal papillary surfaces and consist of an organic matrix and crystals of calcium oxalate and/or calcium phosphate. The matrix is intimately associated with the crystals and contains substances that both promote and inhibit calcification: osteopontin, Tamm-Horsfall protein, bikunin and prothrombin fragment 1. Rats with these stones show decreased urine levels of magnesium and citrate, and the same is believed to occur in humans. Males of both species tend to develop calcium oxalate kidney stones, whereas females tend to form calcium phosphate stones (Khan, World J Urol (1997) 15(4):236-243).
Hexachloro-1,2-butadiene (HCBD) is a solvent that forms toxic conjugates and metabolites with glutathione, cysteine and N-acetyl cysteine. These then cause damage to the S1, S2 and S3 (pars recta) segments of the proximal tubules in the outer medulla of the kidney. Mitochondrial swelling has been observed in the S1 and S2 segments, although most of the pathological changes occur in the S2 and S3 segments (loss of brush boarder and cellular necrosis in S2, necrosis in S3). In rats, HCBD is about four times more toxic to females than to males (Ishmael et al., Toxicol Pathol (1986) 14(2):258-262; Ishmael et al., J Pathol (1982) 138(2):99-113).
Chloroform (CHCl 3 ) is widely used in the manufacture of drugs, cosmetics, plastics and cleaning agents and is a contaminant by-product in chlorinated drinking water. Chloroform was also an early anesthetic used in humans, and, therefore, much is known regarding its toxicity. Exposure can induce liver and kidney damage and cardiac arrthymias.
Toxic levels of exposure in rodents are carcinogenic due to the chronic cycle of cell injury and repair that is induced, rather than because of direct genotoxic action. The injury to the liver and kidney are thought to occur by two different mechanisms related to its metabolism in the target organ. Studies have shown that the extent of liver and kidney damage and necrosis relates multiple factors including sex, strain, route of exposure and the vehicle used. In the kidney, biotransformation of chloroform by cytochrome P450 produces reactive intermediates, which damage mainly the renal proximal tubules. Typical signs of nephrotoxicity include proteinuria, glucosuria and increased BUN levels ( Casarett & Doull's Toxicology: The Basic Science of Poisons 6 th Ed . Klaasen, ed., Chap. 14, pp. 503-508, McGraw-Hill, New York, 2001; Smith et al., Toxicol Appl Pharmacol 70:467-479, 1983).
Diclofenac, a non-steroidal anti-inflammatory drug, is commonly administered to patients suffering from rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Following oral administration, diclofenac is rapidly absorbed and then metabolized in the liver by cytochrome P450 isozyme of the CYC2C subfamily ( Goodman & Gilman's The Pharmacological Basis of Therapeutics 9 th Ed ., Hardman et al., eds., p. 637, McGraw Hill, New York, 1996). In addition, diclofenac is used topically to treat pain due to corneal damage (Jayamanne et al., Eye 11(Pt. 1):79-83, 1997; Domic et al., Am J. Ophthalmol 125(5):719-721, 1998).
Metabolism of diclofenac in kidney tissue produces reactive oxygen species that can cause severe oxidative stress and genomic DNA fragmentation. Examination of diverse types of kidney cells for nuclei with apoptotic characteristics showed that such nuclei are found in the linings of the renal proximal and distal tubules. Additional toxic effects include elevated levels of BUN, malondialdehyde (MDA), SOD, and activated Ca 2+ —Mg 2+ -endonuclease (Hickey et al., Free Radic Biol Med ( 2001) 31(2):139-152).
Thioacetamide's only significant commercial use is as a replacement for hydrogen sulfide in qualitative analyses (IARC, Vol. 7, 1974). It has also been used as an organic solvent in the leather, textile and paper industries, as an accelerator in the vulcanization of buna rubber, and as a stabilizer of motor fuel. The primary routes of human exposure are inhalation and skin contact with products in which thioacetamide was used as a solvent (9th Report on Carcinogens, U.S. Dept. of Health and Human Services, Public Health Service, National Toxicology Program, http://ehp.niehs.nih.gov/roc/toc9.html).
In exposed rats, thioacetamide was shown to accumulate in the liver and kidney, resulting in elevated levels of serum total bilirubin, aspartate aminotransferase, alanine aminotransferase, BUN, creatinine and TNF∀. Impaired clearance of the toxin and increased secretion of TNF∀ are related to the progression of toxic effects in the liver and kidney (Nakatani et al., Liver ( 2001) 21(1):64-70). Additional histological changes in kidney tissue include glomerular tuft collapse and interstitial hemorrhage (Caballero et al., Gut (2001) 48(1):34-40).
Toxicity Prediction and Modeling
The genes and gene expression information, gene expression profiles, as well as the portfolios and subsets of the genes provided in Tables 1-5, may be used to predict at least one toxic effect, including the nephrotoxicity of a test or unknown compound. As used, herein, at least one toxic effect includes, but is not limited to, a detrimental change in the physiological status of a cell or organism. The response may be, but is not required to be, associated with a particular pathology, such as tissue necrosis. Accordingly, the toxic effect includes effects at the molecular and cellular level. Nephrotoxicity is an effect as used herein and includes but is not limited to the pathologies of nephritis, tubular toxicity, kidney necrosis, glomerular and tubular injury, and focal segmental glomerulosclerosis. As used herein, a gene expression profile comprises any quantitative representation of the expression of at least one mRNA species in a cell sample or population and includes profiles made by various methods such as differential display, PCR, microarray and other hybridization analysis, etc.
In general, assays to predict the toxicity or nephrotoxicity of a test agent (or compound or multi-component composition) comprise the steps of exposing a cell population to the test compound, assaying or measuring the level of relative or absolute gene expression of one or more of the genes in Tables 1-5 and comparing the identified expression level(s) to the expression levels disclosed in the Tables and database(s) disclosed herein. Assays may include the measurement of the expression levels of about 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 50, 75, 100 or more genes from Tables 1-5.
In the methods of the invention, the gene expression level for a gene or genes induced by the test agent, compound or compositions may be comparable to the levels found in the Tables or databases disclosed herein if the expression level varies within a factor of about 2, about 1.5 or about 1.0 fold. In some cases, the expression levels are comparable if the agent induces a change in the expression of a gene in the same direction (e.g., up or down) as a reference toxin.
The cell population that is exposed to the test agent, compound or composition may be exposed in vitro or in vivo. For instance, cultured or freshly isolated renal cells, in particular rat renal cells, may be exposed to the agent under standard laboratory and cell culture conditions. In another assay format, in vivo exposure may be accomplished by administration of the agent to a living animal, for instance a laboratory rat.
Procedures for designing and conducting toxicity tests in in vitro and in vivo systems are well known, and are described in many texts on the subject, such as Loomis et al., Loomis's Essentials of Toxicology, 4th Ed., Academic Press, New York, 1996; Echobichon, The Basics of Toxicity Testing, CRC Press, Boca Raton, 1992; Frazier, editor, In Vitro Toxicity Testing, Marcel Dekker, New York, 1992; and the like.
In in vitro toxicity testing, two groups of test organisms are usually employed: One group serves as a control and the other group receives the test compound in a single dose (for acute toxicity tests) or a regimen of doses (for prolonged or chronic toxicity tests). Because, in some cases, the extraction of tissue as called for in the methods of the invention requires sacrificing the test animal, both the control group and the group receiving compound must be large enough to permit removal of animals for sampling tissues, if it is desired to observe the dynamics of gene expression through the duration of an experiment.
In setting up a toxicity study, extensive guidance is provided in the literature for selecting the appropriate test organism for the compound being tested, route of administration. dose ranges, and the like. Water or physiological saline (0.9% NaCl in water) is the solute of choice for the test compound since these solvents permit administration by a variety of routes. When this is not possible because of solubility limitations, vegetable oils such as corn oil or organic solvents such as propylene glycol may be used.
Regardless of the route of administration, the volume required to administer a given dose is limited by the size of the animal that is used. It is desirable to keep the volume of each dose uniform within and between groups of animals. When rats or mice are used, the volume administered by the oral route generally should not exceed about 0.005 ml per gram of animal. Even when aqueous or physiological saline solutions are used for parenteral injection the volumes that are tolerated are limited, although such solutions are ordinarily thought of as being innocuous. The intravenous LD 50 of distilled water in the mouse is approximately 0.044 ml per gram and that of isotonic saline is 0.068 ml per gram of mouse. In some instances, the route of administration to the test animal should be the same as, or as similar as possible to, the route of administration of the compound to man for therapeutic purposes.
When a compound is to be administered by inhalation, special techniques for generating test atmospheres are necessary. The methods usually involve aerosolization or nebulization of fluids containing the compound. If the agent to be tested is a fluid that has an appreciable vapor pressure, it may be administered by passing air through the solution under controlled temperature conditions. Under these conditions, dose is estimated from the volume of air inhaled per unit time, the temperature of the solution, and the vapor pressure of the agent involved. Gases are metered from reservoirs. When particles of a solution are to be administered, unless the particle size is less than about 2 μm the particles will not reach the terminal alveolar sacs in the lungs. A variety of apparatuses and chambers are available to perform studies for detecting effects of irritant or other toxic endpoints when they are administered by inhalation. The preferred method of administering an agent to animals is via the oral route, either by intubation or by incorporating the agent in the feed.
When the agent is exposed to cells in vitro or in cell culture, the cell population to be exposed to the agent may be divided into two or more subpopulations, for instance, by dividing the population into two or more identical aliquots. In some preferred embodiments of the methods of the invention, the cells to be exposed to the agent are derived from kidney tissue. For instance, cultured or freshly isolated rat renal cells may be used.
The methods of the invention may be used generally to predict at least one toxic response, and, as described in the Examples, may be used to predict the likelihood that a compound or test agent will induce various specific kidney pathologies, such as nephritis, kidney necrosis, glomerular and tubular injury, focal segmental glomerulosclerosis, or other pathologies associated with at least one of the toxins herein described. The methods of the invention may also be used to determine the similarity of a toxic response to one or more individual compounds. In addition, the methods of the invention may be used to predict or elucidate the potential cellular pathways influenced, induced or modulated by the compound or test agent due to the similarity of the expression profile compared to the profile induced by a known toxin (see Tables 5-5L).
Diagnostic Uses for the Toxicity Markers
As described above, the genes and gene expression information or portfolios of the genes with their expression information as provided in Tables 1-5 may be used as diagnostic markers for the prediction or identification of the physiological state of tissue or cell sample that has been exposed to a compound or to identify or predict the toxic effects of a compound or agent. For instance, a tissue sample such as a sample of peripheral blood cells or some other easily obtainable tissue sample may be assayed by any of the methods described above, and the expression levels from a gene or genes from Tables 1-5 may be compared to the expression levels found in tissues or cells exposed to the toxins described herein. These methods may result in the diagnosis of a physiological state in the cell or may be used to identify the potential toxicity of a compound, for instance a new or unknown compound or agent. The comparison of expression data, as well as available sequence or other information may be done by researcher or diagnostician or may be done with the aid of a computer and databases as described below.
In another format, the levels of a gene(s) of Tables 1-5, its encoded protein(s), or any metabolite produced by the encoded protein may be monitored or detected in a sample, such as a bodily tissue or fluid sample to identify or diagnose a physiological state of an organism. Such samples may include any tissue or fluid sample, including urine, blood and easily obtainable cells such as peripheral lymphocytes.
Use of the Markers for Monitoring Toxicity Progression
As described above, the genes and gene expression information provided in Tables 1-5 may also be used as markers for the monitoring of toxicity progression, such as that found after initial exposure to a drug, drug candidate, toxin, pollutant, etc. For instance, a tissue or cell sample may be assayed by any of the methods described above, and the expression levels from a gene or genes from Tables 1-5 may be compared to the expression levels found in tissue or cells exposed to the renal toxins described herein. The comparison of the expression data, as well as available sequence or other information may be done by a researcher or diagnostician or may be done with the aid of a computer and databases.
Use of the Toxicity Markers for Drug Screening
According to the present invention, the genes identified in Tables 1-5 may be used as markers or drug targets to evaluate the effects of a candidate drug, chemical compound or other agent on a cell or tissue sample. The genes may also be used as drug targets to screen for agents that modulate their expression and/or activity. In various formats, a candidate drug or agent can be screened for the ability to stimulate the transcription or expression of a given marker or markers or to down-regulate or counteract the transcription or expression of a marker or markers. According to the present invention, one can also compare the specificity of a drug's effects by looking at the number of markers which the drug induces and comparing them. More specific drugs will have less transcriptional targets. Similar sets of markers identified for two drugs may indicate a similarity of effects.
Assays to monitor the expression of a marker or markers as defined in Tables 1-5 may utilize any available means of monitoring for changes in the expression level of the nucleic acids of the invention. As used herein, an agent is said to modulate the expression of a nucleic acid of the invention if it is capable of up- or down-regulating expression of the nucleic acid in a cell.
In one assay format, gene chips containing probes to one, two or more genes from Tables 1-5 may be used to directly monitor or detect changes in gene expression in the treated or exposed cell. Cell lines, tissues or other samples are first exposed to a test agent and in some instances, a known toxin, and the detected expression levels of one or more, or preferably 2 or more of the genes of Tables 1-5 are compared to the expression levels of those same genes exposed to a known toxin alone. Compounds that modulate the expression patterns of the known toxin(s) would be expected to modulate potential toxic physiological effects in vivo. The genes in Tables 1-5 are particularly appropriate markers in these assays as they are differentially expressed in cells upon exposure to a known renal toxin. Tables 1 and 2 disclose those genes that are differentially expressed upon exposure to the named toxins and their corresponding GenBank Accession numbers. Table 3 discloses the human homologues and the corresponding GenBank Accession numbers of the differentially expressed genes of Tables 1 and 2.
In another format, cell lines that contain reporter gene fusions between the open reading frame and/or the transcriptional regulatory regions of a gene in Tables 1-5 and any assayable fusion partner may be prepared. Numerous assayable fusion partners are known and readily available including the firefly luciferase gene and the gene encoding chloramphenicol acetyltransferase (Alam et al. (1990), Anal Biochem 188:245-254). Cell lines containing the reporter gene fusions are then exposed to the agent to be tested under appropriate conditions and time. Differential expression of the reporter gene between samples exposed to the agent and control samples identifies agents which modulate the expression of the nucleic acid.
Additional assay formats may be used to monitor the ability of the agent to modulate the expression of a gene identified in Tables 1-5. For instance, as described above, mRNA expression may be monitored directly by hybridization of probes to the nucleic acids of the invention. Cell lines are exposed to the agent to be tested under appropriate conditions and time, and total RNA or mRNA is isolated by standard procedures such those disclosed in Sambrook et al. (Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989).
In another assay format, cells or cell lines are first identified which express the gene products of the invention physiologically. Cells and/or cell lines so identified would be expected to comprise the necessary cellular machinery such that the fidelity of modulation of the transcriptional apparatus is maintained with regard to exogenous contact of agent with appropriate surface transduction mechanisms and/or the cytosolic cascades. Further, such cells or cell lines may be transduced or transfected with an expression vehicle (e.g., a plasmid or viral vector) construct comprising an operable non-translated 5′-promoter containing end of the structural gene encoding the gene products of Tables 1-5 fused to one or more antigenic fragments or other detectable markers, which are peculiar to the instant gene products, wherein said fragments are under the transcriptional control of said promoter and are expressed as polypeptides whose molecular weight can be distinguished from the naturally occurring polypeptides or may further comprise an immunologically distinct or other detectable tag. Such a process is well known in the art (see Sambrook et al., supra).
Cells or cell lines transduced or transfected as outlined above are then contacted with agents under appropriate conditions; for example, the agent comprises a pharmaceutically acceptable excipient and is contacted with cells comprised in an aqueous physiological buffer such as phosphate buffered saline (PBS) at physiological pH, Eagles balanced salt solution (BSS) at physiological pH, PBS or BSS comprising serum or conditioned media comprising PBS or BSS and/or serum incubated at 37° C. Said conditions may be modulated as deemed necessary by one of skill in the art. Subsequent to contacting the cells with the agent, said cells are disrupted and the polypeptides of the lysate are fractionated such that a polypeptide fraction is pooled and contacted with an antibody to be further processed by immunological assay (e.g., ELISA, immunoprecipitation or Western blot). The pool of proteins isolated from the agent-contacted sample is then compared with the control samples (no exposure and exposure to a known toxin) where only the excipient is contacted with the cells and an increase or decrease in the immunologically generated signal from the agent-contacted sample compared to the control is used to distinguish the effectiveness and/or toxic effects of the agent.
Another embodiment of the present invention provides methods for identifying agents that modulate at least one activity of a protein(s) encoded by the genes in Tables 1-5. Such methods or assays may utilize any means of monitoring or detecting the desired activity.
In one format, the relative amounts of a protein (Tables 1-5) between a cell population that has been exposed to the agent to be tested compared to an un-exposed control cell population and a cell population exposed to a known toxin may be assayed. In this format, probes such as specific antibodies are used to monitor the differential expression of the protein in the different cell populations. Cell lines or populations are exposed to the agent to be tested under appropriate conditions and time. Cellular lysates may be prepared from the exposed cell line or population and a control, unexposed cell line or population. The cellular lysates are then analyzed with the probe, such as a specific antibody.
Agents that are assayed in the above methods can be randomly selected or rationally selected or designed. As used herein, an agent is said to be randomly selected when the agent is chosen randomly without considering the specific sequences involved in the association of a protein of the invention alone or with its associated substrates, binding partners, etc. An example of randomly selected agents is the use a chemical library or a peptide combinatorial library, or a growth broth of an organism.
As used herein, an agent is said to be rationally selected or designed when the agent is chosen on a nonrandom basis which takes into account the sequence of the target site and/or its conformation in connection with the agent's action. Agents can be rationally selected or rationally designed by utilizing the peptide sequences that make up these sites. For example, a rationally selected peptide agent can be a peptide whose amino acid sequence is identical to or a derivative of any functional consensus site.
The agents of the present invention can be, as examples, peptides, small molecules, vitamin derivatives, as well as carbohydrates. Dominant negative proteins, DNAs encoding these proteins, antibodies to these proteins, peptide fragments of these proteins or mimics of these proteins may be introduced into cells to affect function. “Mimic” used herein refers to the modification of a region or several regions of a peptide molecule to provide a structure chemically different from the parent peptide but topographically and functionally similar to the parent peptide (see G. A. Grant in: Molecular Biology and Biotechnology, Meyers, ed., pp. 659-664, VCH Publishers, New York, 1995). A skilled artisan can readily recognize that there is no limit as to the structural nature of the agents of the present invention.
Nucleic Acid Assay Formats
The genes identified as being differentially expressed upon exposure to a known renal toxin (Tables 1-5) may be used in a variety of nucleic acid detection assays to detect or quantify the expression level of a gene or multiple genes in a given sample. The genes described in Tables 1-5 may also be used in combination with one or more additional genes whose differential expression is associate with toxicity in a cell or tissue. In preferred embodiments, the genes in Tables 1-5 may be combined with one or more of the genes described in prior and related application Ser. Nos. 10/152,319, filed May 22, 2002; 60/292,335, filed May 22, 2001; 60/297,523, filed Jun. 13, 2001; 60/298,925, filed Jun. 19, 2001; 60/303,810, filed Jul. 10, 2001; 60/303,807, filed Jul. 10, 2001; 60/303,808, filed Jul. 10, 2001; 60/315,047, filed Aug. 28, 2001; 60/324,928, filed Sep. 27, 2001; 60/330,867, filed Nov. 1, 2001; 60/330,462, filed Oct. 22, 2001; 60/331,805, filed Nov. 21, 2001; 60/336,144, filed Dec. 6, 2001; 60/340,873, filed Dec. 19, 2001; 60/357,843, filed Feb. 21, 2002; 60/357,842, filed Feb. 21, 2002; 60/357,844, filed Feb. 21, 2002; 60/364,134; 60/370,206 filed Mar. 15, 2002, filed Apr. 8, 2002; 60/370,247, filed Apr. 8, 2002; 60/370,144, filed Apr. 8, 2002; 60/371,679, filed Apr. 12, 2002; and 60/372,794, filed Apr. 17, 2002, all of which are incorporated by reference on page 1 of this application.
Any assay format to detect gene expression may be used. For example, traditional Northern blotting, dot or slot blot, nuclease protection, primer directed amplification, RT-PCR, semi- or quantitative PCR, branched-chain DNA and differential display methods may be used for detecting gene expression levels. Those methods are useful for some embodiments of the invention. In cases where smaller numbers of genes are detected, amplification based assays may be most efficient. Methods and assays of the invention, however, may be most efficiently designed with hybridization-based methods for detecting the expression of a large number of genes.
Any hybridization assay format may be used, including solution-based and solid support-based assay formats. Solid supports containing oligonucleotide probes for differentially expressed genes of the invention can be filters, polyvinyl chloride dishes, particles, beads, microparticles or silicon or glass based chips, etc. Such chips, wafers and hybridization methods are widely available, for example, those disclosed by Beattie (WO 95/11755).
Any solid surface to which oligonucleotides can be bound, either directly or indirectly, either covalently or non-covalently, can be used. A preferred solid support is a high density array or DNA chip. These contain a particular oligonucleotide probe in a predetermined location on the array. Each predetermined location may contain more than one molecule of the probe, but each molecule within the predetermined location has an identical sequence. Such predetermined locations are termed features. There may be, for example, from 2, 10, 100, 1000 to 10,000, 100,000 or 400,000 or more of such features on a single solid support. The solid support, or the area within which the probes are attached may be on the order of about a square centimeter. Probes corresponding to the genes of Tables 1-5 or from the related applications described above may be attached to single or multiple solid support structures, e.g., the probes may be attached to a single chip or to multiple chips to comprise a chip set.
Oligonucleotide probe arrays for expression monitoring can be made and used according to any techniques known in the art (see for example, Lockhart et al. (1996), Nat Biotechnol 14:1675-1680; McGall et al. (1996), Proc Nat Acad Sci USA 93: 13555-13460). Such probe arrays may contain at least two or more oligonucleotides that are complementary to or hybridize to two or more of the genes described in Tables 1-5. For instance, such arrays may contain oligonucleotides that are complementary to or hybridize to at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 50, 70, 100 or more of the genes described herein. Preferred arrays contain all or nearly all of the genes listed in Tables 1-5, or individually, the gene sets of Tables 5-5L. In a preferred embodiment, arrays are constructed that contain oligonucleotides to detect all or nearly all of the genes in any one of or all of Tables 1-5 on a single solid support substrate, such as a chip.
The sequences of the expression marker genes of Tables 1-5 are in the public databases. Table 1 provides the GenBank Accession Number or NCBI RefSeq ID for each of the sequences (see www.ncbi.nlm.nih.gov/), as well as the title for the cluster of which gene is part. Table 2 lists the metabolic pathways in which each listed gene functions, while Table 3 provides the gene names and cluster titles for the human homologues of the genes described in Tables 1 and 2. The sequences of the genes in GenBank and/or RefSeq are expressly herein incorporated by reference in their entirety as of the filing date of this application, as are related sequences, for instance, sequences from the same gene of different lengths, variant sequences, polymorphic sequences, genomic sequences of the genes and related sequences from different species, including the human counterparts, where appropriate. These sequences may be used in the methods of the invention or may be used to produce the probes and arrays of the invention. In some embodiments, the genes in Tables 1-5 that correspond to the genes or fragments previously associated with a toxic response may be excluded from the Tables. Table 4 provides the key to the model codes used in Tables 3 and 5-5L, where each model represents a toxin treatment or a set of pathological effects (disease state) resulting from a toxin treatment. In Tables 5A-5L, the genes that are differentially expressed, i.e., up- or down-regulated, in response to a toxin treatment or in a particular disease state are listed. The expression levels of these genes in samples in which a toxic response was found and in samples in which a toxic response was not found are also indicated. The general table (Table 5) is a summation of the data in Tables 5A-5L.
As described above, in addition to the sequences of the GenBank Accession Numbers or NCBI RefSeq ID's disclosed in the Tables 1-5, sequences such as naturally occurring variants or polymorphic sequences may be used in the methods and compositions of the invention. For instance, expression levels of various allelic or homologous forms of a gene disclosed in Tables 1-5 may be assayed, including homologs from species other than rat. Any and all nucleotide variations that do not alter the functional activity of a gene listed in the Tables 1-5, including all naturally occurring allelic variants of the genes herein disclosed, may be used in the methods and to make the compositions (e.g., arrays) of the invention.
Probes based on the sequences of the genes described above may be prepared by any commonly available method. Oligonucleotide probes for screening or assaying a tissue or cell sample are preferably of sufficient length to specifically hybridize only to appropriate, complementary genes or transcripts. Typically the oligonucleotide probes will be at least about 10, 12, 14, 16, 18, 20 or 25 nucleotides in length. In some cases, longer probes of at least 30, 40, or 50 nucleotides will be desirable.
As used herein, oligonucleotide sequences that are complementary to one or more of the genes described in Tables 1-5 refer to oligonucleotides that are capable of hybridizing under stringent conditions to at least part of the nucleotide sequences of said genes. Such hybridizable oligonucleotides will typically exhibit at least about 75% sequence identity at the nucleotide level to said genes, preferably about 80% or 85% sequence identity or more preferably about 90% or 95% or more sequence identity to said genes.
“Bind(s) substantially” refers to complementary hybridization between a probe nucleic acid and a target nucleic acid and embraces minor mismatches that can be accommodated by reducing the stringency of the hybridization media to achieve the desired detection of the target polynucleotide sequence.
The terms “background” or “background signal intensity” refer to hybridization signals resulting from non-specific binding, or other interactions, between the labeled target nucleic acids and components of the oligonucleotide array (e.g., the oligonucleotide probes, control probes, the array substrate, etc.). Background signals may also be produced by intrinsic fluorescence of the array components themselves. A single background signal can be calculated for the entire array, or a different background signal may be calculated for each target nucleic acid. In a preferred embodiment, background is calculated as the average hybridization signal intensity for the lowest 5% to 10% of the probes in the array, or, where a different background signal is calculated for each target gene, for the lowest 5% to 10% of the probes for each gene. Of course, one of skill in the art will appreciate that where the probes to a particular gene hybridize well and thus appear to be specifically binding to a target sequence, they should not be used in a background signal calculation. Alternatively, background may be calculated as the average hybridization signal intensity produced by hybridization to probes that are not complementary to any sequence found in the sample (e.g. probes directed to nucleic acids of the opposite sense or to genes not found in the sample such as bacterial genes where the sample is mammalian nucleic acids). Background can also be calculated as the average signal intensity produced by regions of the array that lack any probes at all.
The phrase “hybridizing specifically to” or “specifically hybridizes” refers to the binding, duplexing, or hybridizing of a molecule substantially to or only to a particular nucleotide sequence or sequences under stringent conditions when that sequence is present in a complex mixture (e.g., total cellular) DNA or RNA.
Assays and methods of the invention may utilize available formats to simultaneously screen at least about 100, preferably about 1000, more preferably about 10,000 and most preferably about 1,000,000 different nucleic acid hybridizations.
As used herein a “probe” is defined as a nucleic acid, capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation. As used herein, a probe may include natural (i.e., A, G, U, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in probes may be joined by a linkage other than a phosphodiester bond, so long as it does not interfere with hybridization. Thus, probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages.
The term “perfect match probe” refers to a probe that has a sequence that is perfectly complementary to a particular target sequence. The test probe is typically perfectly complementary to a portion (subsequence) of the target sequence. The perfect match (PM) probe can be a “test probe”, a “normalization control” probe, an expression level control probe and the like. A perfect match control or perfect match probe is, however, distinguished from a “mismatch control” or “mismatch probe.”
The terms “mismatch control” or “mismatch probe” refer to a probe whose sequence is deliberately selected not to be perfectly complementary to a particular target sequence. For each mismatch (MM) control in a high-density array there typically exists a corresponding perfect match (PM) probe that is perfectly complementary to the same particular target sequence. The mismatch may comprise one or more bases.
While the mismatch(es) may be located anywhere in the mismatch probe, terminal mismatches are less desirable as a terminal mismatch is less likely to prevent hybridization of the target sequence. In a particularly preferred embodiment, the mismatch is located at or near the center of the probe such that the mismatch is most likely to destabilize the duplex with the target sequence under the test hybridization conditions.
The term “stringent conditions” refers to conditions under which a probe will hybridize to its target subsequence, but with only insubstantial hybridization to other sequences or to other sequences such that the difference may be identified. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. Generally, stringent conditions are selected to be about 5° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH.
Typically, stringent conditions will be those in which the salt concentration is at least about 0.01 to 1.0 M Na + ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes (e.g., 10 to 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide.
The “percentage of sequence identity” or “sequence identity” is determined by comparing two optimally aligned sequences or subsequences over a comparison window or span, wherein the portion of the polynucleotide sequence in the comparison window may optionally comprise additions or deletions (i.e., gaps) as compared to the reference sequence (which does not comprise additions or deletions) for optimal alignment of the two sequences. The percentage is calculated by determining the number of positions at which the identical submit (e.g. nucleic acid base or amino acid residue) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison and multiplying the result by 100 to yield the percentage of sequence identity. Percentage sequence identity when calculated using the programs GAP or BESTFIT (see below) is calculated using default gap weights.
Probe Design
One of skill in the art will appreciate that an enormous number of array designs are suitable for the practice of this invention. The high density array will typically include a number of test probes that specifically hybridize to the sequences of interest. Probes may be produced from any region of the genes identified in the Tables and the attached representative sequence listing. In instances where the gene reference in the Tables is an EST, probes may be designed from that sequence or from other regions of the corresponding full-length transcript that may be available in any of the sequence databases, such as those herein described. See WO 99/32660 for methods of producing probes for a given gene or genes. In addition, any available software may be used to produce specific probe sequences, including, for instance, software available from Molecular Biology Insights, Olympus Optical Co. and Biosoft International. In a preferred embodiment, the array will also include one or more control probes.
High density array chips of the invention include “test probes.” Test probes may be oligonucleotides that range from about 5 to about 500, or about 7 to about 50 nucleotides, more preferably from about 10 to about 40 nucleotides and most preferably from about 15 to about 35 nucleotides in length. In other particularly preferred embodiments, the probes are 20 or 25 nucleotides in length. In another preferred embodiment, test probes are double or single strand DNA sequences such as cDNA fragments. DNA sequences are isolated or cloned from natural sources or amplified from natural sources using native nucleic acid as templates. These probes have sequences complementary to particular subsequences of the genes whose expression they are designed to detect. Thus, the test probes are capable of specifically hybridizing to the target nucleic acid they are to detect.
In addition to test probes that bind the target nucleic acid(s) of interest, the high density array can contain a number of control probes. The control probes may fall into three categories referred to herein as 1) normalization controls; 2) expression level controls; and 3) mismatch controls.
Normalization controls are oligonucleotide or other nucleic acid probes that are complementary to labeled reference oligonucleotides or other nucleic acid sequences that are added to the nucleic acid sample to be screened. The signals obtained from the normalization controls after hybridization provide a control for variations in hybridization conditions, label intensity, “reading” efficiency and other factors that may cause the signal of a perfect hybridization to vary between arrays. In a preferred embodiment, signals (e.g., fluorescence intensity) read from all other probes in the array are divided by the signal (e.g., fluorescence intensity) from the control probes thereby normalizing the measurements.
Virtually any probe may serve as a normalization control. However, it is recognized that hybridization efficiency varies with base composition and probe length. Preferred normalization probes are selected to reflect the average length of the other probes present in the array, however, they can be selected to cover a range of lengths. The normalization control(s) can also be selected to reflect the (average) base composition of the other probes in the array, however in a preferred embodiment, only one or a few probes are used and they are selected such that they hybridize well (i.e., no secondary structure) and do not match any target-specific probes.
Expression level controls are probes that hybridize specifically with constitutively expressed genes in the biological sample. Virtually any constitutively expressed gene provides a suitable target for expression level controls. Typically expression level control probes have sequences complementary to subsequences of constitutively expressed “housekeeping genes” including, but not limited to the actin gene, the transferrin receptor gene, the GAPDH gene, and the like.
Mismatch controls may also be provided for the probes to the target genes, for expression level controls or for normalization controls. Mismatch controls are oligonucleotide probes or other nucleic acid probes identical to their corresponding test or control probes except for the presence of one or more mismatched bases. A mismatched base is a base selected so that it is not complementary to the corresponding base in the target sequence to which the probe would otherwise specifically hybridize. One or more mismatches are selected such that under appropriate hybridization conditions (e.g., stringent conditions) the test or control probe would be expected to hybridize with its target sequence, but the mismatch probe would not hybridize (or would hybridize to a significantly lesser extent). Preferred mismatch probes contain a central mismatch. Thus, for example, where a probe is a 20 mer, a corresponding mismatch probe will have the identical sequence except for a single base mismatch (e.g., substituting a G, a C or a T for an A) at any of positions 6 through 14 (the central mismatch).
Mismatch probes thus provide a control for non-specific binding or cross hybridization to a nucleic acid in the sample other than the target to which the probe is directed. For example, if the target is present the perfect match probes should be consistently brighter than the mismatch probes. In addition, if all central mismatches are present, the mismatch probes can be used to detect a mutation, for instance, a mutation of a gene in the accompanying Tables 1-5. The difference in intensity between the perfect match and the mismatch probe provides a good measure of the concentration of the hybridized material.
Nucleic Acid Samples
Cell or tissue samples may be exposed to the test agent in vitro or in vivo. When cultured cells or tissues are used, appropriate mammalian cell extracts, such as liver extracts, may also be added with the test agent to evaluate agents that may require biotransformation to exhibit toxicity. In a preferred format, primary isolates or cultured cell lines of animal or human renal cells may be used.
The genes which are assayed according to the present invention are typically in the form of mRNA or reverse transcribed mRNA. The genes may or may not be cloned. The genes may or may not be amplified. The cloning and/or amplification do not appear to bias the representation of genes within a population. In some assays, it may be preferable, however, to use polyA+RNA as a source, as it can be used with less processing steps.
As is apparent to one of ordinary skill in the art, nucleic acid samples used in the methods and assays of the invention may be prepared by any available method or process. Methods of isolating total mRNA are well known to those of skill in the art. For example, methods of isolation and purification of nucleic acids are described in detail in Chapter 3 of Laboratory Techniques in Biochemistry and Molecular Biology, Vol. 24, Hybridization With Nucleic Acid Probes: Theory and Nucleic Acid Probes, P. Tijssen, Ed., Elsevier Press, New York, 1993. Such samples include RNA samples, but also include cDNA synthesized from a mRNA sample isolated from a cell or tissue of interest. Such samples also include DNA amplified from the cDNA, and RNA transcribed from the amplified DNA. One of skill in the art would appreciate that it is desirable to inhibit or destroy RNase present in homogenates before homogenates are used.
Biological samples may be of any biological tissue or fluid or cells from any organism as well as cells raised in vitro, such as cell lines and tissue culture cells. Frequently the sample will be a tissue or cell sample that has been exposed to a compound, agent, drug, pharmaceutical composition, potential environmental pollutant or other composition. In some formats, the sample will be a “clinical sample” which is a sample derived from a patient. Typical clinical samples include, but are not limited to, sputum, blood, blood-cells (e.g., white cells), tissue or fine needle biopsy samples, urine, peritoneal fluid, and pleural fluid, or cells therefrom. Biological samples may also include sections of tissues, such as frozen sections or formalin fixed sections taken for histological purposes.
Forming High Density Arrays
Methods of forming high density arrays of oligonucleotides with a minimal number of synthetic steps are known. The oligonucleotide analogue array can be synthesized on a single or on multiple solid substrates by a variety of methods, including, but not limited to, light-directed chemical coupling, and mechanically directed coupling (see Pirrung, U.S. Pat. No. 5,143,854).
In brief, the light-directed combinatorial synthesis of oligonucleotide arrays on a glass surface proceeds using automated phosphoramidite chemistry and chip masking techniques. In one specific implementation, a glass surface is derivatized with a silane reagent containing a functional group, e.g., a hydroxyl or amine group blocked by a photolabile protecting group. Photolysis through a photolithographic mask is used selectively to expose functional groups which are then ready to react with incoming 5′ photoprotected nucleoside phosphoramidites. The phosphoramidites react only with those sites which are illuminated (and thus exposed by removal of the photolabile blocking group). Thus, the phosphoramidites only add to those areas selectively exposed from the preceding step. These steps are repeated until the desired array of sequences have been synthesized on the solid surface. Combinatorial synthesis of different oligonucleotide analogues at different locations on the array is determined by the pattern of illumination during synthesis and the order of addition of coupling reagents.
In addition to the foregoing, additional methods which can be used to generate an array of oligonucleotides on a single substrate are described in PCT Publication Nos. WO 93/09668 and WO 01/23614. High density nucleic acid arrays can also be fabricated by depositing pre-made or natural nucleic acids in predetermined positions. Synthesized or natural nucleic acids are deposited on specific locations of a substrate by light directed targeting and oligonucleotide directed targeting. Another embodiment uses a dispenser that moves from region to region to deposit nucleic acids in specific spots.
Hybridization
Nucleic acid hybridization simply involves contacting a probe and target nucleic acid under conditions where the probe and its complementary target can form stable hybrid duplexes through complementary base pairing. See WO 99/32660. The nucleic acids that do not form hybrid duplexes are then washed away leaving the hybridized nucleic acids to be detected, typically through detection of an attached detectable label. It is generally recognized that nucleic acids are denatured by increasing the temperature or decreasing the salt concentration of the buffer containing the nucleic acids. Under low stringency conditions (e.g., low temperature and/or high salt) hybrid duplexes (e.g., DNA:DNA, RNA:RNA, or RNA:DNA) will form even where the annealed sequences are not perfectly complementary. Thus, specificity of hybridization is reduced at lower stringency. Conversely, at higher stringency (e.g., higher temperature or lower salt) successful hybridization tolerates fewer mismatches. One of skill in the art will appreciate that hybridization conditions may be selected to provide any degree of stringency.
In a preferred embodiment, hybridization is performed at low stringency, in this case in 6×SSPET at 37° C. (0.005% Triton X-100), to ensure hybridization and then subsequent washes are performed at higher stringency (e.g., 1×SSPET at 37° C.) to eliminate mismatched hybrid duplexes. Successive washes may be performed at increasingly higher stringency (e.g., down to as low as 0.25×SSPET at 37° C. to 50° C.) until a desired level of hybridization specificity is obtained. Stringency can also be increased by addition of agents such as formamide. Hybridization specificity may be evaluated by comparison of hybridization to the test probes with hybridization to the various controls that can be present (e.g., expression level control, normalization control, mismatch controls, etc.).
In general, there is a tradeoff between hybridization specificity (stringency) and signal intensity. Thus, in a preferred embodiment, the wash is performed at the highest stringency that produces consistent results and that provides a signal intensity greater than approximately 10% of the background intensity. Thus, in a preferred embodiment, the hybridized array may be washed at successively higher stringency solutions and read between each wash. Analysis of the data sets thus produced will reveal a wash stringency above which the hybridization pattern is not appreciably altered and which provides adequate signal for the particular oligonucleotide probes of interest.
Signal Detection
The hybridized nucleic acids are typically detected by detecting one or more labels attached to the sample nucleic acids. The labels may be incorporated by any of a number of means well known to those of skill in the art. See WO 99/32660.
Databases
The present invention includes relational databases containing sequence information, for instance, for the genes of Tables 1-5, as well as gene expression information from tissue or cells exposed to various standard toxins, such as those herein described (see Tables 5-5L). Databases may also contain information associated with a given sequence or tissue sample such as descriptive information about the gene associated with the sequence information (see Tables 1 and 2), or descriptive information concerning the clinical status of the tissue sample, or the animal from which the sample was derived. The database may be designed to include different parts, for instance a sequence database and a gene expression database. Methods for the configuration and construction of such databases and computer-readable media to which such databases are saved are widely available, for instance, see U.S. Pat. No. 5,953,727, which is herein incorporated by reference in its entirety.
The databases of the invention may be linked to an outside or external database such as GenBank (www.ncbi.nlm.nih.gov/entrez.index.html); KEGG (www.genome.ad.jp/kegg); SPAD (www.grt.kyushu-u.acjp/spad/index.html); HUGO (www.gene.ucl.ac.uk/hugo); Swiss-Prot (www.expasy.ch.sprot); Prosite (www.expasy.ch/tools/scnpsitl.html); OMIM (www.ncbi.nlm.nih.gov/omim); and GDB (www.gdb.org). In a preferred embodiment, as described in Tables 1-5, the external database is GenBank and the associated databases maintained by the National Center for Biotechnology Information (NCBI) (www.ncbi.nlm.nih.gov).
Any appropriate computer platform, user interface, etc. may be used to perform the necessary comparisons between sequence information, gene expression information and any other information in the database or information provided as an input. For example, a large number of computer workstations are available from a variety of manufacturers, such has those available from Silicon Graphics. Client/server environments, database servers and networks are also widely available and appropriate platforms for the databases of the invention.
The databases of the invention may be used to produce, among other things, electronic Northerns that allow the user to determine the cell type or tissue in which a given gene is expressed and to allow determination of the abundance or expression level of a given gene in a particular tissue or cell.
The databases of the invention may also be used to present information identifying the expression level in a tissue or cell of a set of genes comprising one or more of the genes in Tables 1-5, comprising the step of comparing the expression level of at least one gene in Tables 1-5 in a cell or tissue exposed to a test agent to the level of expression of the gene in the database. Such methods may be used to predict the toxic potential of a given compound by comparing the level of expression of a gene or genes in Tables 1-5 from a tissue or cell sample exposed to the test agent to the expression levels found in a control tissue or cell samples exposed to a standard toxin or renal toxin such as those herein described. Such methods may also be used in the drug or agent screening assays as described herein.
Kits
The invention further includes kits combining, in different combinations, high-density oligonucleotide arrays, reagents for use with the arrays, protein reagents encoded by the genes of the Tables, signal detection and array-processing instruments, gene expression databases and analysis and database management software described above. The kits may be used, for example, to predict or model the toxic response of a test compound, to monitor the progression of renal disease states, to identify genes that show promise as new drug targets and to screen known and newly designed drugs as discussed above.
The databases packaged with the kits are a compilation of expression patterns from human or laboratory animal genes and gene fragments (corresponding to the genes of Tables 1-5). In particular, the database software and packaged information that may contain the databases saved to a computer-readable medium include the expression results of Tables 1-5 that can be used to predict toxicity of a test agent by comparing the expression levels of the genes of Tables 1-5 induced by the test agent to the expression levels presented in Tables 5-5L. In another format, database and software information may be provided in a remote electronic format, such as a website, the address of which may be packaged in the kit.
The kits may used in the pharmaceutical industry, where the need for early drug testing is strong due to the high costs associated with drug development, but where bioinformatics, in particular gene expression informatics, is still lacking. These kits will reduce the costs, time and risks associated with traditional new drug screening using cell cultures and laboratory animals. The results of large-scale drug screening of pre-grouped patient populations, pharmacogenomics testing, can also be applied to select drugs with greater efficacy and fewer side-effects. The kits may also be used by smaller biotechnology companies and research institutes who do not have the facilities for performing such large-scale testing themselves.
Databases and software designed for use with microarrays is discussed in Balaban et al., U.S. Pat. No. 6,229,911, a computer-implemented method for managing information, stored as indexed Tables 1-5, collected from small or large numbers of microarrays, and U.S. Pat. No. 6,185,561, a computer-based method with data mining capability for collecting gene expression level data, adding additional attributes and reformatting the data to produce answers to various queries. Chee et al., U.S. Pat. No. 5,974,164, disclose a software-based method for identifying mutations in a nucleic acid sequence based on differences in probe fluorescence intensities between wild type and mutant sequences that hybridize to reference sequences.
Without further description, it is believed that one of ordinary skill in the art can, using the preceding description and the following illustrative examples, make and utilize the compounds of the present invention and practice the claimed methods. The following working examples therefore, specifically point out the preferred embodiments of the present invention, and are not to be construed as limiting in any way the remainder of the disclosure.
EXAMPLES
Example 1
Identification of Toxicity Markers
The renal toxins indomethacin, diflunisal, colchicine, chloroform, diclofenac, menadione, sodium chromate, sodium oxalate, thioacetamide, and vancomycin were administered to male Sprague-Dawley rats at various timepoints using administration diluents, protocols and dosing regimes as previously described in the art and previously described in the priority applications discussed above. In experiments using toxins A-G, as labeled in Table 4, blood and tissue samples were collected at the following time-points: chloroform (A), thioacetamide (F) and vancomycin (G)—after 6, 24 and 48 hours of exposure; diclofenac (B) and menadione (C)—after 3, 6 and 24 hours of exposure; and sodium chromate (D) and sodium oxalate (E)—after 6, 24 and 72 hours of exposure. For these compounds, no significant changes in the levels of gene expression were found with varying exposure time, i.e., short and long time-points showed the same pattern of differential gene expression. The low and high dose level for each compound are provided in the chart below.
Low Method of Renal Toxin Dose (mg/kg) High Dose (mg/kg) Administration indomethacin 1 10 oral gavage diflunisal 2 400 oral gavage colchicine 0.15 1.5 intraperitoneal chloroform 11.95 239 oral gavage diclofenac 1 200 intraperitoneal menadione 15 150 intravenous sodium chromate 3 30 intraperitoneal sodium oxalate 10 100 intraperitoneal thioacetamide 30 300 intraperitoneal vancomycin 50 500 intravenous

After administration, the dosed animals were observed and tissues were collected as described below:
Observation of Animals
1. Clinical cage side observations—twice daily mortality and moribundity check. Skin and fur, eyes and mucous membrane, respiratory system, circulatory system, autonomic and central nervous system, somatomotor pattern, and behavior pattern were checked. Potential signs of toxicity, including tremors, convulsions, salivation, diarrhea, lethargy, coma or other atypical behavior or appearance, were recorded as they occurred and included a time of onset, degree, and duration.
2. Physical Examinations—Prior to randomization, prior to initial treatment, and prior to sacrifice.
3. Body Weights—Prior to randomization, prior to initial treatment, and prior to sacrifice.
Clinical Pathology
1. Frequency—Prior to necropsy.
2. Number of animals—All surviving animals.
3. Bleeding Procedure—Blood was obtained by puncture of the orbital sinus while under 70% CO 2 /30% O 2 anesthesia.
4. Collection of Blood Samples—Approximately 0.5 mL of blood was collected into EDTA tubes for evaluation of hematology parameters. Approximately 1 mL of blood was collected into serum separator tubes for clinical chemistry analysis. Approximately 200 uL of plasma was obtained and frozen at ˜−80° C. for test compound/metabolite estimation. An additional ˜2 mL of blood was collected into a 15 mL conical polypropylene vial to which ˜3 mL of Trizol was immediately added. The contents were immediately mixed with a vortex and by repeated inversion. The tubes were frozen in liquid nitrogen and stored at ˜−80° C.
Termination Procedures
Terminal Sacrifice
Approximately 3, 6, 24, 48, 72, 120, 144, 168, 336, and/or 360 hours after the initial dose, rats were weighed, physically examined, sacrificed by decapitation, and exsanguinated. The animals were necropsied within approximately five minutes of sacrifice. Separate sterile, disposable instruments were used for each animal, with the exception of bone cutters, which were used to open the skull cap. The bone cutters were dipped in disinfectant solution between animals.
Necropsies were conducted on each animal following procedures approved by board-certified pathologists.
Animals not surviving until terminal sacrifice were discarded without necropsy (following euthanasia by carbon dioxide asphyxiation, if moribund). The approximate time of death for moribund or found dead animals was recorded.
Postmortem Procedures
Fresh and sterile disposable instruments were used to collect tissues. Gloves were worn at all times when handling tissues or vials. All tissues were collected and frozen within approximately 5 minutes of the animal's death. The liver sections and kidneys were frozen within approximately 3-5 minutes of the animal's death. The time of euthanasia, an interim time point at freezing of liver sections and kidneys, and time at completion of necropsy were recorded. Tissues were stored at approximately −80° C. or preserved in 10% neutral buffered formalin.
Tissue Collection and Processing
Liver
1. Right medial lobe—snap frozen in liquid nitrogen and stored at ˜−80° C. 2. Left medial lobe—Preserved in 10% neutral-buffered formalin (NBF) and evaluated for gross and microscopic pathology. 3. Left lateral lobe—snap frozen in liquid nitrogen and stored at ˜−80° C.

Heart—A sagittal cross-section containing portions of the two atria and of the two ventricles was preserved in 10% NBF. The remaining heart was frozen in liquid nitrogen and stored at ˜−80° C.
Kidneys (both)
1. Left—Hemi-dissected; half was preserved in 10% NBF and the remaining half was frozen in liquid nitrogen and stored at ˜−80° C. 2. Right—Hemi-dissected; half was preserved in 10% NBF and the remaining half was frozen in liquid nitrogen and stored at ˜−80° C.

Testes (both)—A sagittal cross-section of each testis was preserved in 10% NBF. The remaining testes were frozen together in liquid nitrogen and stored at ˜−80° C.
Brain (whole)—A cross-section of the cerebral hemispheres and of the diencephalon was preserved in 10% NBF, and the rest of the brain was frozen in liquid nitrogen and stored at ˜−80° C.
Microarray sample preparation was conducted with minor modifications, following the protocols set forth in the Affymetrix GeneChip Expression Analysis Manual. Frozen tissue was ground to a powder using a Spex Certiprep 6800 Freezer Mill. Total RNA was extracted with Trizol (GibcoBRL) utilizing the manufacturer's protocol. The total RNA yield for each sample was 200-500 μg per 300 mg tissue weight. mRNA was isolated using the Oligotex mRNA Midi kit (Qiagen) followed by ethanol precipitation. Double stranded cDNA was generated from mRNA using the SuperScript Choice system (GibcoBRL). First strand cDNA synthesis was primed with a T7-(dT24) oligonucleotide. The cDNA was phenol-chloroform extracted and ethanol precipitated to a final concentration of 1 μg/ml. From 2 μg of cDNA, cRNA was synthesized using Ambion's T7 MegaScript in vitro Transcription Kit.
To biotin label the cRNA, nucleotides Bio-11-CTP and Bio-16-UTP (Enzo Diagnostics) were added to the reaction. Following a 37° C. incubation for six hours, impurities were removed from the labeled cRNA following the RNeasy Mini kit protocol (Qiagen). cRNA was fragmented (fragmentation buffer consisting of 200 mM Tris-acetate, pH 8.1, 500 mM KOAc, 150 mM MgOAc) for thirty-five minutes at 94° C. Following the Affymetrix protocol, 55 μg of fragmented cRNA was hybridized on the Affymetrix rat array set for twenty-four hours at 60 rpm in a 45° C. hybridization oven. The chips were washed and stained with Streptavidin Phycoerythrin (SAPE) (Molecular Probes) in Affymetrix fluidics stations. To amplify staining, SAPE solution was added twice with an anti-streptavidin biotinylated antibody (Vector Laboratories) staining step in between. Hybridization to the probe arrays was detected by fluorometric scanning (Hewlett Packard Gene Array Scanner). Data was analyzed using Affymetrix GeneChip® version 2.0 and Expression Data Mining (EDMT) software (version 1.0), GeneExpress2000, and S-Plus.
Tables 1 and 2 disclose those genes that are differentially expressed upon exposure to the named toxins and their corresponding GenBank Accession and Sequence Identification numbers, the identities of the metabolic pathways in which the genes function, the gene names if known, and the unigene cluster titles. The model code represents the various toxicity state that each gene is able to discriminate as well as the individual toxin type associated with each gene. The codes are defined in Table 4. The GLGC ID is the internal Gene Logic identification number.
Table 3 discloses those genes that are the human homologues of those genes in Tables 1 and 2 that are differentially expressed upon exposure to the named toxins. The corresponding GenBank Accession and Sequence Identification numbers, the gene names if known, and the unigene cluster titles of the human homologues are listed.
Table 4 defines the comparison codes used in Tables 1, 2, 3, and 5.
Tables 5-5L disclose the summary statistics for each of the comparisons performed. Each of these tables contains a set of predictive genes and creates a model for predicting the renal toxicity of an unknown, i.e., untested compound. Each gene is identified by its Gene Logic identification number and can be cross-referenced to a gene name and representative SEQ ID NO. in Tables 1 and 2. For each comparison of gene expression levels between samples in the toxicity group (samples affected by exposure to a specific toxin) and samples in the non-toxicity group (samples not affected by exposure to that same specific toxin), the tox mean (for toxicity group samples) is the mean signal intensity, as normalized for the various chip parameters that are being assayed. The non-tox mean represents the mean signal intensity, as normalized for the various chip parameters that are being assayed, in samples from animals other than those treated with the high dose of the specific toxin. These animals were treated with a low dose of the specific toxin, or with vehicle alone, or with a different toxin. Samples in the toxicity groups were obtained from animals sacrificed at the timepoint(s) indicated in the Table 5 headings, while samples in the non-toxicity groups were obtained from animals sacrificed at all time points in the experiments. For individual genes, an increase in the tox mean compared to the non-tox mean indicates up-regulation upon exposure to a toxin. Conversely, a decrease in the tox mean compared to the non-tox mean indicates down-regulation.
The mean values are derived from Average Difference (AveDiff) values for a particular gene, averaged across the corresponding samples. Each individual Average Difference value is calculated by integrating the intensity information from multiple probe pairs that are tiled for a particular fragment. The normalization multiplies each expression intensity for a given experiment (chip) by a global scaling factor. The intent of this normalization is to make comparisons of individual genes between chips possible. The scaling factor is calculated as follows:
1. From all the unnormalized expression values in the experiment, delete the largest 2% and smallest 2% of the values. That is, if the experiment yields 10,000 expression values, order the values and delete the smallest 200 and the largest 200.
2. Compute the trimmed mean, which is equal to the mean of the remaining values.
3. Compute the scale factor SF=100/(trimmed mean).
The value of 100 used here is the standard target value used. Some AveDiff values may be negative due to the general noise involved in nucleic acid hybridization experiments. Although many conclusions can be made corresponding to a negative value on the GeneChip platform, it is difficult to assess the meaning behind the negative value for individual fragments. Our observations show that, although negative values are observed at times within the predictive gene set, these values reflect a real biological phenomenon that is highly reproducible across all the samples from which the measurement was taken. For this reason, those genes that exhibit a negative value are included in the predictive set. It should be noted that other platforms of gene expression measurement may be able to resolve the negative numbers for the corresponding genes. The predictive ability of each of those genes should extend across platforms, however. Each mean value is accompanied by the standard deviation for the mean. The linear discriminant analysis score (discriminant score), as disclosed in the tables, measures the ability of each gene to predict whether or not a sample is toxic. The discriminant score is calculated by the following steps:
Calculation of a Discriminant Score


1. Let X i represent the AveDiff values for a given gene across the non-tox samples, i=1 . . . n.
2. Let Y i represent the AveDiff values for a given gene across the tox samples, i=1 . . . t. The calculations proceed as follows:
3. Calculate mean and standard deviation for X i 's and Y i 's, and denote these by m X , m Y , s X , s Y .
4. For all X i 's and Y i 's, evaluate the function f(z)=((1/s Y )*exp(−0.5*((z−m Y )/s Y ) 2 ))/(((1/s Y )*exp(−0.5*((z−m Y )/s Y ) 2 ))+((1/s X )*exp(−0.5*((z−m X )/s X ) 2 ))).
5. The number of correct predictions, say P, is then the number of Y i 's such that f(Y i )>0.5 plus the number of X i 's such that f(X i )<0.5.
6. The discriminant score is then P/(n+t).


Linear discriminant analysis uses both the individual measurements of each gene and the calculated measurements of all combinations of genes to classify samples. For each gene a weight is derived from the mean and standard deviation of the toxic and nontox groups. Every gene is multiplied by a weight and the sum of these values results in a collective discriminate score. This discriminant score is then compared against collective centroids of the tox and nontox groups. These centroids are the average of all tox and nontox samples respectively. Therefore, each gene contributes to the overall prediction. This contribution is dependent on weights that are large positive or negative numbers if the relative distances between the tox and nontox samples for that gene are large and small numbers if the relative distances are small. The discriminant score for each unknown sample and centroid values can be used to calculate a probability between zero and one as to the group in which the unknown sample belongs.
Example 2
General Toxicity Modeling
Samples were selected for grouping into tox-responding and non-tox-responding groups by examining each study individually with Principal Components Analysis (PCA) to determine which treatments had an observable response. Only groups where confidence of their tox-responding and non-tox-responding status was established were included in building a general tox model (Table 5).
Linear discriminant models were generated to describe toxic and non-toxic samples. The top discriminant genes and/or EST's were used to determine toxicity by calculating each gene's contribution with homo and heteroscedastic treatment of variance and inclusion or exclusion of mutual information between genes. Prediction of samples within the database exceeded 80% true positives with a false positive rate of less than 5%. It was determined that combinations of genes and/or EST's generally provided a better predictive ability than individual genes and that the more genes and/or EST used the better predictive ability. Although the preferred embodiment includes fifty or more genes, many pairings or greater combinations of genes and/or EST can work better than individual genes. All combinations of two or more genes from the selected list (Table 5) could be used to predict toxicity. These combinations could be selected by pairing in an agglomerate, divisive, or random approach. Further, as yet undetermined genes and/or EST's could be combined with individual or combination of genes and/or EST's described here to increase predictive ability. However, the genes and/or EST's described here would contribute most of the predictive ability of any such undetermined combinations.
Other variations on the above method can provide adequate predictive ability. These include selective inclusion of components via agglomerate, divisive, or random approaches or extraction of loading and combining them in agglomerate, divisive, or random approaches. Also the use of composite variables in logistic regression to determine classification of samples can also be accomplished with linear discriminate analysis, neural or Bayesian networks, or other forms of regression and classification based on categorical or continual dependent and independent variables.
Example 3
Modeling Methods
The above modeling methods provide broad approaches of combining the expression of genes to predict sample toxicity. One could also provide no weight in a simple voting method or determine weights in a supervised or unsupervised method using agglomerate, divisive, or random approaches. All or selected combinations of genes may be combined in ordered, agglomerate, or divisive, supervised or unsupervised clustering algorithms with unknown samples for classification. Any form of correlation matrix may also be used to classify unknown samples. The spread of the group distribution and discriminate score alone provide enough information to enable a skilled person to generate all of the above types of models with accuracy that can exceed discriminate ability of individual genes. Some examples of methods that could be used individually or in combination after transformation of data types include but are not limited to: Discriminant Analysis, Multiple Discriminant Analysis, logistic regression, multiple regression analysis, linear regression analysis, conjoint analysis, canonical correlation, hierarchical cluster analysis, k-means cluster analysis, self-organizing maps, multidimensional scaling, structural equation modeling, support vector machine determined boundaries, factor analysis, neural networks, bayesian classifications, and resampling methods.
Example 4
Grouping of Individual Compound and Pathology Classes
Samples were grouped into individual pathology classes based on known toxicological responses and observed clinical chemical and pathology measurements or into early and late phases of observable toxicity within a compound (Tables 5A-5L). The top 10, 25, 50, 100 genes based on individual discriminate scores were used in a model to ensure that combination of genes provided a better prediction than individual genes. As described above, all combinations of two or more genes from this list could potentially provide better prediction than individual genes when selected in any order or by ordered, agglomerate, divisive, or random approaches. In addition, combining these genes with other genes could provide better predictive ability, but most of this predictive ability would come from the genes listed herein.
Samples may be considered toxic if they score positive in any pathological or individual compound class represented here or in any modeling method mentioned under general toxicology models based on combination of individual time and dose grouping of individual toxic compounds obtainable from the data. The pathological groupings and early and late phase models are preferred examples of all obtainable combinations of sample time and dose points. Most logical groupings with one or more genes and one or more sample dose and time points should produce better predictions of general toxicity, pathological specific toxicity, or similarity to known toxicant than individual genes.
Although the present invention has been described in detail with reference to examples above, it is understood that various modifications can be made without departing from the spirit of the invention. Accordingly, the invention is limited only by the following claims. All cited patents, patent applications and publications referred to in this application are herein incorporated by reference in their entirety.
TABLE 1 ANNOTATIONS Atty. Docket No. GENE-077/26US Doc. No. 44941 GLGC GenBank Acc Identifier Seq ID or RefSeq ID Model Code Known Gene Name Sequence Cluster Title 23758 285 AA956414 C, G ESTs, Weakly similar to ACDS_RAT Acyl- CoA dehydrogenase, short-chain specific, mitochondrial precursor (SCAD) (Butyryl- CoA dehydrogenase) [ R. norvegicus ] 16625 324 AA998062 D HHs: Alg5, S. cerevisiae , ESTs, Highly similar to T51776 dolichyl- homolog of phosphate beta-glucosyltransferase (EC 2.4.1.117) [imported] - human [ H. sapiens ] 24648 1046 NM_030985 GENERAL Rattus norvegicus Angiotensin II receptor, type 1 (AT1A) Angiotensin II receptor, type 1 (AT1A) (Agtr1a), mRNA. Length = 1450 21462 77 AA851261 GENERAL, J ESTs, Highly similar to A61382 phosphorylation regulatory protein HP-10 - human [ H. sapiens ] 5867 85 AA858953 GENERAL ESTs, Moderately similar to SYN_HUMAN Asparaginyl-tRNA synthetase, cytoplasmic (Asparagine - tRNA ligase) (AsnRS) [ H. sapiens ] 21632 359 AI009167 GENERAL, ESTs, Highly similar to BAG2_HUMAN H, I BAG-family molecular chaperone regulator-2 [ H. sapiens ] 23957 291 AA957123 GENERAL ESTs, Weakly similar to NADE_HUMAN p75NTR-associated cell death executor (Nerve growth factor receptor associated protein 1) (Ovarian granulosa cell 13.0 kDa protein HGR74) [ H. sapiens ] 12716 372 AI010178 GENERAL ESTs, Moderately similar to CA00_HUMAN Protein CGI-100 precursor [ H. sapiens ] 3121 353 AI008160 GENERAL, ESTs, Moderately similar to T44603 G, K hypothetical protein CGI-83 [imported] - human [ H. sapiens ] 8944 466 AI070597 F ESTs, Highly similar to YC97_HUMAN Hypothetical protein CGI-97 [ H. sapiens ] 4360 785 H31813 GENERAL, ESTs, Moderately similar to T14781 G, I hypothetical protein DKFZp586B1621.1 - human (fragment) [ H. sapiens ] 3834 629 AI177902 G ESTs, Highly similar to T14743 hypothetical protein DKFZp586F1524.1 - human (fragment) [ H. sapiens ] 4373 153 AA892310 F ESTs, Highly similar to T08783 hypothetical protein DKFZp586O0120.1 - human (fragment) [ H. sapiens ] 5990 290 AA956907 GENERAL ESTs, Highly similar to IF3A_MOUSE EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 10 (EIF-3 THETA) (EIF3 P167) (EIF3 P180) (EIF3 P185) (P162 PROTEIN) (CENTROSOMIN) [ M. musculus ] 17921 607 AI176422 F ESTs, Highly similar to S41115 probable flavoprotein-ubiquinone oxidoreductase (EC 1.6.5.—) - human [ H. sapiens ] 3439 185 AA893000 B ESTs, Moderately similar to T00335 hypothetical protein KIAA0564 - human (fragment) [ H. sapiens ] 13607 640 AI179403 H ESTs, Weakly similar to U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (U5 snRNP-specific 200 kDa protein) (U5-200 KD) [ H. sapiens ] 20810 1235 X14181 G ESTs, Highly similar to R5RT18 ribosomal protein L18a, cytosolic [validated] - rat [ R. norvegicus ] 17734 1114 NM_031970 GENERAL, Rattus norvegicus Heat ESTs, Moderately similar to hypothetical C, I shock 27 kDa protein protein MGC10974 [ Homo sapiens ] (Hsp27), mRNA. Length = 787 [ H. sapiens ], heat shock 27 kD protein 1 17735 1114 NM_031970 C, K Rattus norvegicus Heat ESTs, Moderately similar to hypothetical shock 27 kDa protein protein MGC10974 [ Homo sapiens ] (Hsp27), mRNA. Length = 787 [ H. sapiens ], heat shock 27 kD protein 1 17736 1114 NM_031970 H, K Rattus norvegicus Heat ESTs, Moderately similar to hypothetical shock 27 kDa protein protein MGC10974 [ Homo sapiens ] (Hsp27), mRNA. Length = 787 [ H. sapiens ], heat shock 27 kD protein 1 7414 557 AI137586 K ESTs, Highly similar to IMB3_HUMAN Importin beta-3 subunit (Karyopherin beta 3 subunit) (Ran-binding protein 5) [ H. sapiens ] 15302 9 AA799518 GENERAL ESTs, Highly similar to hypothetical protein FLJ13725; KIAA1930 protein [ Homo sapiens ] [ H. sapiens ] 15303 9 AA799518 F ESTs, Highly similar to hypothetical protein FLJ13725; KIAA1930 protein [ Homo sapiens ] [ H. sapiens ] 19412 66 AA849222 D ESTs, Weakly similar to T46904 hypothetical protein DKFZp761D081.1 - human [ H. sapiens ] 13563 718 AI233773 E MAWD binding protein MAWD binding protein 5952 298 AA963102 E amino acid transporter amino acid transporter system A2 system A2 5481 647 AI180170 GENERAL ESTs, Highly similar to S50853 translation releasing factor eRF-1 [validated] - human [ H. sapiens ] 23987 1238 X51615 B ESTs, Highly similar to 1604368A gap junction protein Cx26 [ Rattus norvegicus ] [ R. norvegicus ] 7451 420 AI029450 L ESTs, Moderately similar to SYEP_HUMAN Bifunctional aminoacyl- tRNA synthetase [includes: Glutamyl- tRNA synthetase (Glutamate - tRNA ligase); Prolyl-tRNA synthetase (Proline - tRNA ligase)] [ H. sapiens ] 16756 38 AA818089 GENERAL, HHs: glycyl-tRNA synthetase ESTs, Highly similar to SYG_HUMAN A, I Glycyl-tRNA synthetase ( Glycine - tRNA ligase) (GlyRS) [ H. sapiens ] 13285 586 AI171361 A ESTs, Moderately similar to A Chain A, Musashi1 Rbd2, Nmr [ M. musculus ] 8820 1186 NM_080399 B, H, L Rattus norvegicus Smhs1 Smhs1 protein protein (Smhs1), mRNA. Length = 1107 23282 1232 U90725 A lipoprotein-binding protein lipoprotein-binding protein 3083 459 AI060150 E ESTs, Moderately similar to HIRA- interacting protein 3 [ Homo sapiens ] [ H. sapiens ] 3816 716 AI233729 H ESTs, Moderately similar to PSD5_HUMAN 26S proteasome non- ATPase regulatory subunit 5 (26S proteasome subunit S5B) (26S protease subunit S5 basic) [ H. sapiens ] 8739 469 AI070859 D ESTs, Weakly similar to T48686 hypothetical protein DKFZp761D1823.1 - human [ H. sapiens ] 24197 462 AI070314 B, L ESTs, Moderately similar to ARVC_HUMAN Armadillo repeat protein deleted in velo-cardio-facial syndrome [ H. sapiens ] 7540 450 AI045882 GENERAL, vitamin A-deficient testicular vitamin A-deficient testicular protein 5 B, L protein 5 22592 410 AI013740 GENERAL, ESTs, Moderately similar to S32567 A4 G, K protein - human [ H. sapiens ] 11164 735 AI235739 GENERAL, I ESTs, Moderately similar to A56716 aromatic ester hydrolase (EC 3.1.1.—) - human [ H. sapiens ] 22984 220 AA924560 E ESTs, Highly similar to T12449 hypothetical protein DKFZp564E1616.1 - human (fragments) [ H. sapiens ] 6518 391 AI012114 GENERAL ESTs, Moderately similar to TRM1_HUMAN Probable N(2),N(2)- dimethylguanosine tRNA methyltransferase (tRNA(guanine-26,N(2) N(2)) methyltransferase) (tRNA 2,2- dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) [ H. sapiens ] 8665 483 AI071965 C ESTs, Moderately similar to T17342 hypothetical protein DKFZp586K1924.1 - human (fragment) [ H. sapiens ], R. norvegicus hsp70.2 mRNA for heat shock protein 70 8664 1261 Z75029 C, D ESTs, Moderately similar to T17342 hypothetical protein DKFZp586K1924.1 - human (fragment) [ H. sapiens ], R. norvegicus hsp70.2 mRNA for heat shock protein 70 22569 646 AI179979 GENERAL, I ESTs, Moderately similar to hypothetical protein FLJ21634 [ Homo sapiens ] [ H. sapiens ] 18128 134 AA891800 I ESTs, Weakly similar to IPYR_HUMAN Inorganic pyrophosphatase (Pyrophosphate phospho-hydrolase) (PPase) [ H. sapiens ] 15339 113 AA875171 D ESTs, Weakly similar to T45062 hypothetical protein c316G12.3 [imported] - human [ H. sapiens ] 5369 567 AI169058 A ESTs, Weakly similar to JC5889 OS-9 protein precursor - human [ H. sapiens ] 18168 247 AA942995 E ESTs, Highly similar to T50630 hypothetical protein DKFZp762N0610.1 - human (fragment) [ H. sapiens ] 2191 203 AA894086 F ESTs, Highly similar to hypothetical protein MGC17552 [ Homo sapiens ] [ H. sapiens ] 16731 293 AA957244 D ESTs, Moderately similar to JTV1; hypothetical protein PRO0992 [ Homo sapiens ] [ H. sapiens ] 3053 320 AA997726 H ESTs, Highly similar to RRP5_HUMAN RRP5 protein homolog (Fragment) [ H. sapiens ] 10069 452 AI058503 F ESTs, Moderately similar to Y247_HUMAN Hypothetical protein KIAA0247 [ H. sapiens ] 22490 206 AA899289 A ESTs, Moderately similar to KIAA1049 protein [ Homo sapiens ] [ H. sapiens ] 21653 753 AI237535 GENERAL, LPS-induced TNF-alpha LPS-induced TNF-alpha factor C, K factor 21654 1221 U53184 GENERAL, LPS-induced TNF-alpha LPS-induced TNF-alpha factor I, L factor 8317 149 AA892234 GENERAL ESTs, Moderately similar to microsomal glutathione S-transferase 3; microsomal glutathione S-transferase III [ Homo sapiens ] [ H. sapiens ] 17923 178 AA892843 D ESTs, Moderately similar to hypothetical protein FLJ20917 [ Homo sapiens ] [ H. sapiens ] 20866 236 AA926098 J ESTs, Moderately similar to mitochondrial ribosomal protein L53 [ Homo sapiens ] [ H. sapiens ] 21672 132 AA891789 C, D ESTs, Highly similar to MRGX_HUMAN Transcription factor-like protein MRGX (MORF-related gene X protein) [ H. sapiens ] 16881 190 AA893185 J ESTs, Moderately similar to NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 (16 kD, SGDH) [ Homo sapiens ] [ H. sapiens ] 18509 526 AI104528 A ESTs, Weakly similar to NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 (17 kD, B17) [ Homo sapiens ] [ H. sapiens ] 3099 664 AI229680 E HHs: NADH dehydrogenase ESTs, Moderately similar to NADH (ubiquinone) Fe—S protein 3 dehydrogenase (ubiquinone) Fe—S (30 kD) (NADH-coenzyme Q protein 3 (30 kD) (NADH-coenzyme Q reductase) reductase) [ Homo sapiens ] [ H. sapiens ] 23843 296 AA957410 D ESTs, Highly similar to NCK adaptor protein 2 [ Homo sapiens ] [ H. sapiens ] 3874 419 AI029428 GENERAL, I ESTs, Highly similar to S50082 nuclear cap binding protein - human [ H. sapiens ] 3875 727 AI235047 GENERAL, A ESTs, Highly similar to S50082 nuclear cap binding protein - human [ H. sapiens ] 13111 553 AI137224 GENERAL ESTs, Weakly similar to T02435 probable oxysterol-binding protein DJ430N08.1 - human (fragment) [ H. sapiens ] 7270 406 AI013564 D ESTs, Highly similar to PEST-containing nuclear protein [ Homo sapiens ] [ H. sapiens ] 7888 715 AI233583 GENERAL ESTs, Highly similar to SYR_HUMAN ARGINYL-TRNA SYNTHETASE (ARGININE—TRNA LIGASE) (ARGRS) [ H. sapiens ], ESTs, Moderately similar to JC4365 arginine-tRNA ligase (EC 6.1.1.19) - human [ H. sapiens ] 235 978 NM_019347 C Rattus norvegicus solute Urea transporter carrier family 14, member 2 (Slc14a2), mRNA. Length = 3974 17514 232 AA925554 E, G succinate dehydrogenase succinate dehydrogenase complex, complex, subunit A, subunit A, flavoprotein (Fp) flavoprotein (Fp) 12031 201 AA893860 GENERAL, I HHs: threonyl-tRNA ESTs, Moderately similar to synthetase SYTC_HUMAN Threonyl-tRNA synthetase, cytoplasmic (Threonine - tRNA ligase) (ThrRS) [ H. sapiens ] 16469 160 AA892462 A, C ESTs, Moderately similar to UCRY_HUMAN Ubiquinol-cytochrome C reductase complex 6.4 kDa protein (Complex III subunit XI) [ H. sapiens ] 16468 238 AA926137 A ESTs, Moderately similar to UCRY_HUMAN Ubiquinol-cytochrome C reductase complex 6.4 kDa protein (Complex III subunit XI) [ H. sapiens ] 15576 148 AA892132 J ESTs, Moderately similar to uncharacterized hematopoietic stem/progenitor cells protein MDS032 [ Homo sapiens ] [ H. sapiens ] 15409 1182 NM_057197 L Rattus norvegicus 2,4- 2,4-dienoyl CoA reductase 1, dienoyl CoA reductase 1, mitochondrial mitochondrial (Decr1), mRNA. Length = 1109 22602 341 AF044574 GENERAL putative peroxisomal 2,4- putative peroxisomal 2,4-dienoyl-CoA dienoyl-CoA reductase reductase 20493 988 NM_020076 GENERAL Rattus norvegicus 3- 3-hydroxyanthranilate 3,4-dioxygenase hydroxyanthranilate 3,4- dioxygenase (Haao), mRNA. Length = 1254 20494 988 NM_020076 E Rattus norvegicus 3- 3-hydroxyanthranilate 3,4-dioxygenase hydroxyanthranilate 3,4- dioxygenase (Haao), mRNA. Length = 1254 21950 412 AI013861 G 3-hydroxyisobutyrate 3-hydroxyisobutyrate dehydrogenase dehydrogenase 1527 934 NM_017220 B Rattus norvegicus 6-pyruvoyl- 6-pyruvoyl-tetrahydropterin synthase tetrahydropterin synthase (Pts), mRNA. Length = 1176 13485 989 NM_020306 B Rattus norvegicus a a disintegrin and metalloproteinase disintegrin and domain 17 metalloproteinase domain 17 (Adam17), mRNA. Length = 4128 2153 1227 U75404 GENERAL, L A kinase (PRKA) anchor A kinase (PRKA) anchor protein (gravin) protein (gravin) 12 12 17516 950 NM_017321 A, E, L Rattus norvegicus iron- iron-responsive element-binding protein responsive element-binding protein (Ratireb), mRNA. Length = 3564 19991 1169 NM_053961 K Rattus norvegicus mitochondrial aconitase (nuclear aco2 endoplasmic retuclum protein gene) 29 (Erp29), mRNA. Length = 4529 16708 864 NM_012895 GENERAL Rattus norvegicus Adenosin Adenosin kinase kinase (Adk), mRNA. Length = 1086 15032 852 NM_012816 GENERAL, Rattus norvegicus alpha- alpha-methylacyl-CoA racemase A, H, I, K, L methylacyl-CoA racemase (Amacr), mRNA. Length = 1504 18564 865 NM_012899 GENERAL Rattus norvegicus aminolevulinate, delta-, dehydratase aminolevulinate, delta-, dehydratase (Alad), mRNA. Length = 1116 21038 1042 NM_024484 H Rattus norvegicus aminolevulinic acid synthase 1 aminolevulinic acid synthase 1 (Alas1), mRNA. Length = 2052 21039 1042 NM_024484 H Rattus norvegicus aminolevulinic acid synthase 1 aminolevulinic acid synthase 1 (Alas1), mRNA. Length = 2052 2079 966 NM_019220 F Rattus norvegicus amino- amino-terminal enhancer of split terminal enhancer of split (Aes), mRNA. Length = 1356 744 983 NM_019622 GENERAL Rattus norvegicus espin espin (Espn), mRNA. Length = 2786 7196 867 NM_012904 GENERAL, Rattus norvegicus Annexin 1 Annexin 1 (p35) (Lipocortin 1) E, G, K (p35) (Lipocortin 1) (Anxa1), mRNA. Length = 1402 7197 867 NM_012904 GENERAL, Rattus norvegicus Annexin 1 Annexin 1 (p35) (Lipocortin 1) G, K, L (p35) (Lipocortin 1) (Anxa1), mRNA. Length = 1402 21391 1192 NM_130416 GENERAL, K Rattus norvegicus annexin annexin A7 A7 (Anxa7), mRNA. Length = 2912 16649 891 NM_013132 GENERAL, E Rattus norvegicus Annexin V Annexin V (Anx5), mRNA. Length = 1417 16650 891 NM_013132 E Rattus norvegicus Annexin V Annexin V (Anx5), mRNA. Length = 1417 20801 1033 NM_024148 GENERAL, Rattus norvegicus apurinic/apyrimidinic endonuclease 1 H, I, J, L apurinic/apyrimidinic endonuclease 1 (Apex1), mRNA. Length = 1213 20173 959 NM_019136 C Rattus norvegicus Vasopressin receptor V2 Vasopressin receptor V2 (Avpr2), mRNA. Length = 1116 20725 1149 NM_053602 A Rattus norvegicus ATP ATP synthase, H+ transporting, synthase, H+ transporting, mitochondrial F0 complex, subunit F6 mitochondrial F0 complex, subunit F6 (Atp5j), mRNA. Length = 573 18449 1204 U00926 H ATP synthase, H+ ATP synthase, H+ transporting, transporting, mitochondrial mitochondrial F1 complex, delta subunit F1 complex, delta subunit 16907 35 AA817977 C ESTs, Weakly similar to VATC_MOUSE Vacuolar ATP synthase subunit C (V- ATPase C subunit) (Vacuolar proton pump C subunit) [ M. musculus ] 15701 1187 NM_080581 A, I Rattus norvegicus ATP- ATP-binding cassette, sub-family C binding cassette, sub-family (CFTR/MRP), member 3 C (CFTR/MRP), member 3 (Abcc3), mRNA. Length = 5174 9176 490 AI072675 A ESTs, Highly similar to TO1A_MOUSE Torsin A precursor [ M. musculus ] 20582 93 AA859688 A, E, F, K ESTs, Highly similar to AU RNA-binding enoyl-coenzyme A hydratase; AU RNA- binding protein/enoyl-coenzyme A hydratase [ Mus musculus ] [ M. musculus ] 21562 1185 NM_078623 A Rattus norvegicus Enoyl-CoA Enoyl-CoA hydratase, short chain 1, hydratase, short chain 1, mitochondrial mitochondrial (Echs1), mRNA. Length = 1454 5565 1153 NM_053618 GENERAL, C Rattus norvegicus Bardet- Bardet-Biedl syndrome 2 (human) Biedl syndrome 2 (human) (Bbs2), mRNA. Length = 2573 15299 942 NM_017259 GENERAL, Rattus norvegicus B-cell Early induced gene, B-cell translocation I, J translocation gene 2, anti- gene 2 proliferative (Btg2), mRNA. Length = 2519 15300 942 NM_017259 GENERAL Rattus norvegicus B-cell Early induced gene, B-cell translocation translocation gene 2, anti- gene 2 proliferative (Btg2), mRNA. Length = 2519 23679 974 NM_019290 C, L Rattus norvegicus B-cell B-cell translocation gene 3 translocation gene 3 (Btg3), mRNA. Length = 1259 23033 1188 NM_080888 A, C, K Rattus norvegicus BCL2/adenovirus E1B 19 kDa-interacting BCL2/adenovirus E1B 19 kDa- protein 3-like interacting protein 3-like (Bnip3l), mRNA. Length = 3219 15171 690 AI231792 H ESTs, Highly similar to BAG3_MOUSE BAG-family molecular chaperone regulator-3 (BCL-2 binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) [ M. musculus ] 17824 54 AA819362 A ESTs, Highly similar to hypothetical protein MGC7474 [ Mus musculus ] [ M. musculus ] 17823 76 AA851214 D ESTs, Highly similar to hypothetical protein MGC7474 [ Mus musculus ] [ M. musculus ] 1888 1177 NM_057130 B Rattus norvegicus BH3 BH3 interacting (with BCL2 family) interacting (with BCL2 family) domain, apoptosis agonist domain, apoptosis agonist (Bid3), mRNA. Length = 5253 439 854 NM_012827 F Rattus norvegicus Bone Bone morphogenetic protein 4 morphogenetic protein 4 (Bmp4), mRNA. Length = 1758 15035 855 NM_012836 B Rattus norvegicus Carboxypeptidase D precursor Carboxypeptidase D precursor (Cpd), mRNA. Length = 4377 20555 1120 NM_031987 F Rattus norvegicus carnitine carnitine O-octanoyltransferase O-octanoyltransferase (Crot), mRNA. Length = 2681 1977 870 NM_012930 L Rattus norvegicus Carnitine Carnitine palmitoyltransferase 2 palmitoyltransferase 2 (Cpt2), mRNA. Length = 2296 16116 1105 NM_031775 F Rattus norvegicus caspase 6 caspase 6 (Casp6), mRNA. Length = 1446 24672 810 M34097 C Rat natural killer (NK) cell protease 1 (RNKP-1) mRNA, complete cds 1894 949 NM_017320 B, L Rattus norvegicus cathepsin cathepsin S S (Ctss), mRNA. Length = 1330 21239 1029 NM_024125 GENERAL, Rattus norvegicus Liver Liver activating protein (LAP, also NF- H, I activating protein (LAP, also IL6, nuclear factor-IL6, previously NF-IL6, nuclear factor-IL6, designated TCF5) previously designated TCF5) (Cebpb), mRNA. Length = 1408 21683 896 NM_013154 GENERAL, Rattus norvegicus CCAAT/enhancerbinding, protein C, I, L CCAAT/enhancerbinding, (C/EBP) delta protein (C/EBP) delta (Cebpd), mRNA. Length = 1200 21651 975 NM_019296 E Rattus norvegicus Cell Cell division cycle control protein 2 division cycle control protein 2 (Cdc2a), mRNA. Length = 1184 19936 1071 NM_031357 D Rattus norvegicus ceroid- ceroid-lipofuscinosis, neuronal 2 lipofuscinosis, neuronal 2 (Cln2), mRNA. Length = 2485 17154 1161 NM_053835 J Rattus norvegicus clathrin, clathrin, light polypeptide (Lcb) light polypeptide (Lcb) (Cltb), mRNA. Length = 982 20404 1094 NM_031700 L Rattus norvegicus claudin 3 claudin 3 (Cldn3), mRNA. Length = 1192 20405 1094 NM_031700 B Rattus norvegicus claudin 3 claudin 3 (Cldn3), mRNA. Length = 1192 15364 921 NM_017147 J Rattus norvegicus cofilin 1, cofilin 1, non-muscle non-muscle (Cfl1), mRNA. Length = 1039 15851 1219 U42719 GENERAL Complement component 4 Complement component 4 2782 326 AA998565 J ESTs, Moderately similar to CDNC_MOUSE CYCLIN-DEPENDENT KINASE INHIBITOR 1C (CYCLIN- DEPENDENT KINASE INHIBITOR P57) (P57KIP2) [ M. musculus ] 291 822 NM_012522 GENERAL, F Rattus norvegicus Cystathionine beta synthase Cystathionine beta synthase (Cbs), mRNA. Length = 2363 19003 1189 NM_080903 F Rattus norvegicus ring finger ring finger protein 28 protein 28 (Rnf28), mRNA. Length = 1861 15028 1129 NM_052809 F Rattus norvegicus cytosolic cytosolic cysteine dioxygenase 1 cysteine dioxygenase 1 (Cdo1), mRNA. Length = 1458 4234 1068 NM_031330 K Rattus norvegicus heterogeneous nuclear ribonucleoprotein heterogeneous nuclear A/B ribonucleoprotein A/B (Hnrpab), mRNA. Length = 3061 4235 1068 NM_031330 GENERAL, Rattus norvegicus heterogeneous nuclear ribonucleoprotein H, K, L heterogeneous nuclear A/B ribonucleoprotein A/B (Hnrpab), mRNA. Length = 3061 17226 1031 NM_024131 C, E Rattus norvegicus D- D-dopachrome tautomerase dopachrome tautomerase (Ddt), mRNA. Length = 628 17227 1031 NM_024131 E Rattus norvegicus D- D-dopachrome tautomerase dopachrome tautomerase (Ddt), mRNA. Length = 628 4327 1144 NM_053563 GENERAL, Rattus norvegicus nuclear nuclear RNA helicase, DECD variant of G, I RNA helicase, DECD variant DEAD box family of DEAD box family (Ddxl), mRNA. Length = 1511 24459 1183 NM_057209 C Rattus norvegicus myosin myosin light chain kinase 2, skeletal light chain kinase 2, skeletal muscle muscle (Mylk2), mRNA. Length = 2799 4504 1035 NM_024159 D Rattus norvegicus DOC-2 disabled homolog 2, mitogen-responsive p82 isoform (Dab2), mRNA. phosphoprotein ( Drosophila ) Length = 3170 14267 389 AI011738 A ESTs, Highly similar to P044_RAT 0-44 protein [ R. norvegicus ] 18713 987 NM_020075 L Rattus norvegicus eukaryotic eukaryotic initiation factor 5 (eIF-5) initiation factor 5 (eIF-5) (Eif5), mRNA. Length = 3504 18716 987 NM_020075 F Rattus norvegicus eukaryotic eukaryotic initiation factor 5 (eIF-5) initiation factor 5 (eIF-5) (Eif5), mRNA. Length = 3504 21157 271 AA946189 I ESTs, Moderately similar to RGP1_MOUSE Ran-GTPase activating protein 1 [ M. musculus ] 19834 1179 NM_057139 E Rattus norvegicus transporter protein; system N1 Na+ and transporter protein; system H+-coupled glutamine transporter N1 Na+ and H+-coupled glutamine transporter (Hnrpu), mRNA. Length = 3563 23868 825 NM_012551 GENERAL, L Rattus norvegicus Early Early growth response 1 growth response 1 (Egr1), mRNA. Length = 3112 23869 825 NM_012551 L Rattus norvegicus Early Early growth response 1 growth response 1 (Egr1), mRNA. Length = 3112 23872 825 NM_012551 GENERAL Rattus norvegicus Early Early growth response 1 growth response 1 (Egr1), mRNA. Length = 3112 20865 795 L00117 GENERAL Elastase 1 Elastase 1 17268 686 AI231317 F ESTs, Highly similar to endothelial- derived gene [ Mus musculus ] [ M. musculus ] 23194 159 AA892417 GENERAL ephrin A1 ephrin A1 21509 1044 NM_030847 G Rattus norvegicus epithelial epithelial membrane protein 3 membrane protein 3 (Emp3), mRNA. Length = 737 17541 858 NM_012844 GENERAL, Rattus norvegicus Epoxide Epoxide hydrolase 1 (microsomal A, B, H, I hydrolase 1 (microsomal xenobiotic hydrolase) xenobiotic hydrolase) (Ephx1), mRNA. Length = 1242 2465 812 M59814 G, K Eph receptor B2 (ELK- Eph receptor B2 (ELK-related protein related protein tyrosine tyrosine kinase) kinase) 10015 973 NM_019289 GENERAL, Rattus norvegicus Actin- Actin-related protein complex 1b G, K related protein complex 1b (Arpc1b), mRNA. Length = 1430 10016 973 NM_019289 GENERAL, G Rattus norvegicus Actin- Actin-related protein complex 1b related protein complex 1b (Arpc1b), mRNA. Length = 1430 1246 847 NM_012770 GENERAL, J Rattus norvegicus Guanylate Guanylate cyclase, soluble, beta 2 (GTP cyclase, soluble, beta 2 (GTP pyrophosphate —lyase) pyrophosphate - lyase) (Gucy1b2), mRNA. Length = 2335 6405 801 L38615 G Glutathione synthetase gene Glutathione synthetase gene 15850 749 AI236795 K ESTs, ESTs, Highly similar to HS9B_RAT Heat shock protein HSP 90-beta (HSP 84) [ R. norvegicus ] 6758 405 AI013394 B, L heparan sulfate heparan sulfate (glucosamine) 3-O- (glucosamine) 3-O- sulfotransferase 1 sulfotransferase 1 16967 895 NM_013146 E Rattus norvegicus Caldesmon 1 Caldesmon 1 (Cald1), mRNA. Length = 5541 17198 828 NM_012593 G Rattus norvegicus Kallikrein Kallikrein 1, renal/pancreas/salivary 1, renal/pancreas/salivary (Klk1), mRNA. Length = 786 17684 154 AA892345 GENERAL, I dimethylglycine dimethylglycine dehydrogenase dehydrogenase precursor precursor 1535 331 AB000778 F Phoshpolipase D gene 1 Phoshpolipase D gene 1 23115 29 AA801165 A, F Testis-specific histone 2a Testis-specific histone 2a 25702 1244 X58465 G Ribosomal protein S5 Ribosomal protein S5 10109 1244 X58465 G Ribosomal protein S5 Ribosomal protein S5 15185 1062 NM_031140 GENERAL Rattus norvegicus vimentin vimentin (Vim), mRNA. Length = 1796 1509 962 NM_019157 A Rattus norvegicus aquaporin aquaporin 7 7 (Aqp7), mRNA. Length = 1267 17907 708 AI233224 GENERAL Epidermal growth factor Epidermal growth factor receptor, receptor, formerly avian formerly avian erythroblastic leukemia erythroblastic leukemia viral viral (v-erbB) oncogene homolog (Erbb1) (v-erbB) oncogene homolog (Erbb1) 16476 1036 NM_024162 GENERAL, L Rattus norvegicus heart fatty Fatty acid binding protein 3, muscle and acid binding protein (Fabp3), heart mRNA. Length = 666 20711 905 NM_016999 L Rattus norvegicus Cytochrome P450, subfamily IVB, Cytochrome P450, subfamily polypeptide 1 IVB, polypeptide 1 (Cyp4b1), mRNA. Length = 2462 20713 905 NM_016999 J, L Rattus norvegicus Cytochrome P450, subfamily IVB, Cytochrome P450, subfamily polypeptide 1 IVB, polypeptide 1 (Cyp4b1), mRNA. Length = 2462 20714 905 NM_016999 J, L Rattus norvegicus Cytochrome P450, subfamily IVB, Cytochrome P450, subfamily polypeptide 1 IVB, polypeptide 1 (Cyp4b1), mRNA. Length = 2462 20715 905 NM_016999 L Rattus norvegicus Cytochrome P450, subfamily IVB, Cytochrome P450, subfamily polypeptide 1 IVB, polypeptide 1 (Cyp4b1), mRNA. Length = 2462 989 976 NM_019318 D, F Rattus norvegicus v-maf v-maf musculoaponeurotic fibrosarcoma musculoaponeurotic (avian) oncogene homolog (c-maf) fibrosarcoma (avian) oncogene homolog (c-maf) (Maf), mRNA. Length = 1944 1447 944 NM_017281 D Rattus norvegicus proteasome (prosome, macropain) proteasome (prosome, subunit, alpha type 4 macropain) subunit, alpha type 4 (Psma4), mRNA. Length = 1121 1857 1064 NM_031315 L Rattus norvegicus acyl-CoA acyl-CoA thioesterase 1, cytosolic thioesterase 1, cytosolic (Cte1), mRNA. Length = 1591 11849 1052 NM_031065 GENERAL, G Rattus norvegicus ribosomal ribosomal protein L10a protein L10a (Rpl10a), mRNA. Length = 710 17104 924 NM_017160 GENERAL, G Rattus norvegicus ribosomal ribosomal protein S6 protein S6 (Rps6), mRNA. Length = 801 21575 1093 NM_031698 J Rattus norvegicus ribophorin ribophorin II II (Rpn2), mRNA. Length = 2234 17175 1243 X58389 GENERAL R. norvegicus ASI mRNA for mammalian equivalent of bacterial large ribosomal subunit protein L22 24108 679 AI230728 G ESTs, Highly similar to S42114 small nuclear ribonucleoprotein U1A - mouse [ M. musculus ] 15191 608 AI176456 GENERAL, ESTs, Highly similar to SMRT2 F, L metallothionein II - rat [ R. norvegicus ] 21491 1027 NM_022951 B Rattus norvegicus putative putative protein phosphatase 1 nuclear protein phosphatase 1 targeting subunit nuclear targeting subunit (Ppp1r10), mRNA. Length = 4131 6917 1 AA012709 B ESTs, Highly similar to splicing factor 3b, subunit 1, 155 kDa [ Mus musculus ] [ M. musculus ] 16204 1096 NM_031706 GENERAL, G Rattus norvegicus ribosomal ribosomal protein S8 protein S8 (Rps8), mRNA. Length = 696 16205 1096 NM_031706 F Rattus norvegicus ribosomal ribosomal protein S8 protein S8 (Rps8), mRNA. Length = 696 15135 1170 NM_053971 G Rattus norvegicus ribosomal ribosomal protein L6 protein L6 (Rpl6), mRNA. Length = 963 3995 388 AI011678 GENERAL, Ryudocan/syndecan 2 Ryudocan/syndecan 2 I, K 1529 884 NM_013082 GENERAL, Rattus norvegicus Ryudocan/syndecan 2 B, F, I Ryudocan/syndecan 2 (Sdc2), mRNA. Length = 2153 22321 1109 NM_031832 GENERAL, Rattus norvegicus IgE lectin, galactose binding, soluble 3 B, G, L binding protein (Lgals3), mRNA. Length = 948 13633 1041 NM_024403 GENERAL Rattus norvegicus activating activating transcription factor ATF-4 transcription factor ATF-4 (Atf4), mRNA. Length = 1173 13634 1041 NM_024403 GENERAL Rattus norvegicus activating activating transcription factor ATF-4 transcription factor ATF-4 (Atf4), mRNA. Length = 1173 17357 899 NM_013183 GENERAL, Rattus norvegicus Meprin 1 Meprin 1 beta F, G, I, L beta (Mep1b), mRNA. Length = 2290 16929 1056 NM_031108 G Rattus norvegicus mRNA for mRNA for ribosomal protein S9 ribosomal protein S9 (Rps9), mRNA. Length = 688 15653 1236 X14210 G NADH ubiquinone NADH ubiquinone oxidoreductase oxidoreductase subunit B13 subunit B13 19712 994 NM_021745 K Rattus norvegicus farnesoid nuclear receptor subfamily 1, group H, X activated receptor member 4 (LOC60351), mRNA. Length = 2070 24563 1026 NM_022676 G, K Rattus norvegicus protein protein phosphatase 1, regulatory phosphatase 1, regulatory (inhibitor) subunit 1A (inhibitor) subunit 1A (Ppp1r1a), mRNA. Length = 619 24564 1026 NM_022676 G, K Rattus norvegicus protein protein phosphatase 1, regulatory phosphatase 1, regulatory (inhibitor) subunit 1A (inhibitor) subunit 1A (Ppp1r1a), mRNA. Length = 619 24615 1057 NM_031112 D Rattus norvegicus ribosomal ribosomal protein S24 protein S24 (Rps24), mRNA. Length = 466 16676 762 AI639082 E mini chromosome mini chromosome maintenance deficient maintenance deficient 6 ( S. cerevisiae ) 6 ( S. cerevisiae ) 16674 1208 U17565 E mini chromosome mini chromosome maintenance deficient maintenance deficient 6 ( S. cerevisiae ) 6 ( S. cerevisiae ) 16675 1208 U17565 E mini chromosome mini chromosome maintenance deficient maintenance deficient 6 ( S. cerevisiae ) 6 ( S. cerevisiae ) 13151 860 NM_012862 GENERAL Rattus norvegicus Matrix Gla Matrix Gla protein protein (Mgp), mRNA. Length = 521 24472 117 AA875523 L ESTs, Highly similar to MLES_RAT Myosin light chain alkali, smooth-muscle isoform (MLC3SM) [ R. norvegicus ] 4532 958 NM_019134 J Rattus norvegicus Solute Solute carrier family 12, member 1 carrier family 12, member 1 (bumetanide-sensitive sodium- (bumetanide-sensitive [potassium]-chloride cotransporter) sodium-[potassium]-chloride cotransporter) (Slc12a1), mRNA. Length = 4595 1597 1151 NM_053611 L Rattus norvegicus nuclear nuclear proten 1 proten 1 (Nupr1), mRNA. Length = 602 14138 94 AA859700 GENERAL HMm:protoporphyrinogen ESTs, Highly similar to PPOX_MOUSE oxidase PROTOPORPHYRINOGEN OXIDASE (PPO) [ M. musculus ] 5208 747 AI236754 G pregnancy-induced growth pregnancy-induced growth inhibitor inhibitor 18606 1239 X53504 GENERAL ESTs, Highly similar to RL12_RAT 60S RIBOSOMAL PROTEIN L12 [ R. norvegicus ] 6049 3 AA685178 F ESTs, Highly similar to T30827 nascent polypeptide-associated complex alpha chain, non-muscle splice form - mouse [ M. musculus ] 11953 501 AI102505 A cytochrome c oxidase, cytochrome c oxidase, subunit VIIIa subunit VIIIa 3987 943 NM_017280 GENERAL Rattus norvegicus proteasome (prosome, macropain) proteasome (prosome, subunit, alpha type 3 macropain) subunit, alpha type 3 (Psma3), mRNA. Length = 897 20876 910 NM_017050 J Rattus norvegicus Superoxide dismutase 1, soluble Superoxide dismutase 1, soluble (Sod1), mRNA. Length = 650 6059 632 AI178245 GENERAL, J ESTs, Moderately similar to T13963 formin related protein, lymphocyte specific - mouse [ M. musculus ] 17159 787 J00797 GENERAL, alpha-tubulin alpha-tubulin G, K 17161 1002 NM_022298 GENERAL Rattus norvegicus alpha- alpha-tubulin tubulin (Tuba1), mRNA. Length = 1617 13974 103 AA860030 GENERAL, F Rattus norvegicus mRNA for class I beta- tubulin, complete cds 13973 334 AB011679 E Rattus norvegicus mRNA for class I beta- tubulin, complete cds 15050 520 AI103911 I HHs:ubiquinol-cytochrome c ESTs, Highly similar to A32296 ubiquinol- reductase, Rieske iron-sulfur cytochrome-c reductase (EC 1.10.2.2) polypeptide 1 Rieske iron-sulfur protein precursor - rat (fragment) [ R. norvegicus ] 16913 652 AI228236 E ESTs, Highly similar to neuronal protein 15.6 [ Mus musculus ] [ M. musculus ] 1340 1098 NM_031715 B Rattus norvegicus phosphofructokinase, muscle phosphofructokinase, muscle (Pfkm), mRNA. Length = 2757 16684 882 NM_013052 GENERAL Rattus norvegicus Tyrosine 3- Tyrosine 3-monooxygenase/tryptophan 5- monooxygenase/tryptophan monooxygenase activation protein, eta 5-monooxygenase activation polypeptide protein, eta polypeptide (Ywhah), mRNA. Length = 1689 20082 771 AI639488 GENERAL, HMm:transformed mouse ESTs, Highly similar to A42772 mdm2 H, I, J 3T3 cell double minute 2 protein - rat (fragments) [ R. norvegicus ] 45 904 NM_016996 GENERAL, Rattus norvegicus Calcium- Calcium-sensing receptor (hypocalciuric J, L sensing receptor hypercalcemia 1, severe neonatal (hypocalciuric hypercalcemia hyperparathyroidism) 1, severe neonatal hyperparathyroidism) (Casr), mRNA. Length = 4113 19268 1055 NM_031104 D Rattus norvegicus ribosomal ribosomal protein L22 protein L22 (Rpl22), mRNA. Length = 465 25279 877 NM_013011 C Rattus norvegicus Tyrosine 3- Tyrosine 3-monooxygenase/tryptophan 5- monooxygenase/tryptophan monooxygenase activation protein, zeta 5-monooxygenase activation polypeptide protein, zeta polypeptide (Ywhaz), mRNA. Length = 1687 17393 875 NM_012992 GENERAL Rattus norvegicus Nucleoplasmin-related protein (Nuclear Nucleoplasmin-related protein B23 protein (Nuclear protein B23 (Npm1), mRNA. Length = 1232 17394 875 NM_012992 GENERAL, L Rattus norvegicus Nucleoplasmin-related protein (Nuclear Nucleoplasmin-related protein B23 protein (Nuclear protein B23 (Npm1), mRNA. Length = 1232 4198 814 M83143 GENERAL, I Rat beta-galactoside-alpha 2,6- sialyltransferase mRNA 4199 814 M83143 GENERAL Rat beta-galactoside-alpha 2,6- sialyltransferase mRNA 1877 911 NM_017052 A, D, E Rattus norvegicus Sorbitol Sorbitol dehydrogenase dehydrogenase (Sord), mRNA. Length = 1358 21078 902 NM_016986 G Rattus norvegicus Acyl- Acyl-Coenzyme A dehydrogenase, C-4 to Coenzyme A C-12 straight-chain dehydrogenase, C-4 to C-12 straight-chain (Acadm), mRNA. Length = 1866 22626 1040 NM_024400 GENERAL, K Rattus norvegicus a a disintegrin and metalloproteinase with disintegrin and thrombospondin motifs 1 (ADAMTS-1) metalloproteinase with thrombospondin motifs 1 (ADAMTS-1) (Adamts1), mRNA. Length = 4878 19235 441 AI045074 GENERAL ESTs, Highly similar to BGAL_MOUSE Beta-galactosidase precursor (Lactase) (Acid beta-galactosidase) [ M. musculus ] 13954 1168 NM_053955 GENERAL Rattus norvegicus crystallin, crystallin, mu mu (Crym), mRNA. Length = 1227 2242 1138 NM_053433 GENERAL, Rattus norvegicus flavin- flavin-containing monooxygenase 3 H, I, J containing monooxygenase 3 (Fmo3), mRNA. Length = 2037 1546 1231 U85512 GENERAL, G GTP cyclohydrolase I GTP cyclohydrolase I feedback feedback regulatory protein regulatory protein 1409 1124 NM_033349 GENERAL, Rattus norvegicus Hydroxyacyl glutathione hydrolase A, C, E, F Hydroxyacyl glutathione hydrolase (Hagh), mRNA. Length = 783 5206 235 AA925755 E Glutaminase Glutaminase 24211 540 AI111853 G ESTs, Highly similar to H33_HUMAN Histone H3.3 (H3.A) (H3.B) (H3.3Q) [ M. musculus ] 15642 1172 NM_053985 GENERAL, Rattus norvegicus H3 H3 histone, family 3B F, J histone, family 3B (H3f3b), mRNA. Length = 1107 67 1085 NM_031605 B Rattus norvegicus cytochrome P450, 4a10 cytochrome P450, 4a10 (Cyp4a10), mRNA. Length = 1957 1764 1171 NM_053974 C Rattus norvegicus eukaryotic eukaryotic translation initiation factor 4E translation initiation factor 4E (Eif4e), mRNA. Length = 1647 21659 382 AI010584 D Rattus norvegicus interferon-inducible protein variant 10 mRNA, complete cds 21657 1247 X61381 GENERAL Rattus norvegicus interferon-inducible protein variant 10 mRNA, complete cds 1712 892 NM_013138 GENERAL Rattus norvegicus Inositol 1, Inositol 1,4,5-triphosphate receptor 3 4,5-triphosphate receptor 3 (ltpr3), mRNA. Length = 8806 755 890 NM_013126 GENERAL Rattus norvegicus Diacylglycerol kinase 3 (gamma) Diacylglycerol kinase 3 (gamma) (Dgkg), mRNA. Length = 3466 18011 1082 NM_031588 GENERAL, H Rattus norvegicus neuregulin neuregulin 1 1 (Nrg1), mRNA. Length = 3272 1081 1097 NM_031712 GENERAL, D Rattus norvegicus PDZ PDZ domain containing 1 domain containing 1 (Pdzk1), mRNA. Length = 2005 19998 1125 NM_033352 GENERAL Rattus norvegicus ATP- PDZ domain containing 1 binding cassette, sub-family D (ALD), member 2 (Abcd2), mRNA. Length = 5531 13369 1157 NM_053742 D Rattus norvegicus phosphotidylinositol transfer protein, beta phosphotidylinositol transfer protein, beta (Pitpnb), mRNA. Length = 2680 472 780 D26111 G R. norvegicus mRNA for chloride channel (putative) 2313 bp 605 935 NM_017221 C Rattus norvegicus sonic sonic hedgehog homolog, ( Drosophila ) hedgehog homolog, ( Drosophila ) (Shh), mRNA. Length = 1715 16871 863 NM_012887 E Rattus norvegicus Thymopoietin (lamina associated Thymopoietin (lamina polypeptide 2) associated polypeptide 2) (Tmpo), mRNA. Length = 3508 14121 1202 S82383 I R. norvegicus mRNA for tropomyosin isoform 6 6055 831 NM_012619 GENERAL, D Rattus norvegicus Phenylalanine hydroxylase Phenylalanine hydroxylase (Pah), mRNA. Length = 1998 24438 817 M85183 GENERAL, angiotensin/vasopressin angiotensin/vasopressin receptor F, L receptor 8984 1014 NM_022539 D Rattus norvegicus initiation methionine aminopeptidase 2 factor 2 associated 67 kDa protein (Amp2), mRNA. Length = 1944 19252 1145 NM_053576 H Rattus norvegicus thiol- peroxiredoxin 5 specific antioxidant protein (Prdx5), mRNA. Length = 1414 19254 1145 NM_053576 H Rattus norvegicus thiol- peroxiredoxin 5 specific antioxidant protein (Prdx5), mRNA. Length = 1414 17401 881 NM_013043 GENERAL, Rattus norvegicus Transforming growth factor beta B, G Transforming growth factor stimulated clone 22 beta stimulated clone 22 (Tgfb1i4), mRNA. Length = 1666 4449 827 NM_012592 B, G, K Rattus norvegicus Isovaleryl Isovaleryl Coenzyme A dehydrogenase Coenzyme A dehydrogenase (Ivd), mRNA. Length = 2104 4450 827 NM_012592 E Rattus norvegicus Isovaleryl Isovaleryl Coenzyme A dehydrogenase Coenzyme A dehydrogenase (Ivd), mRNA. Length = 2104 4451 827 NM_012592 GENERAL, F Rattus norvegicus Isovaleryl Isovaleryl Coenzyme A dehydrogenase Coenzyme A dehydrogenase (Ivd), mRNA. Length = 2104 645 977 NM_019345 G, K Rattus norvegicus solute solute carrier family 12, member 3 carrier family 12, member 3 (Slc12a3), mRNA. Length = 4361 646 977 NM_019345 G, K Rattus norvegicus solute solute carrier family 12, member 3 carrier family 12, member 3 (Slc12a3), mRNA. Length = 4361 17473 1132 NM_053319 GENERAL, K Rattus norvegicus dynein, dynein, cytoplasmic, light chain 1 cytoplasmic, light chain 1 (Pin), mRNA. Length = 505 1884 783 D50695 I proteasome (prosome, proteasome (prosome, macropain) 26S macropain) 26S subunit, subunit, ATPase, 4 ATPase, 4 2439 970 NM_019277 A, F Rattus norvegicus SEC15 SEC15 homolog ( S. cerevisiae ) homolog ( S. cerevisiae ) (Sec15), mRNA. Length = 3059 14346 1075 NM_031533 B, H Rattus norvegicus Rat UDP-glucuronosyltransferase mRNA, Androsterone UDP- complete cds glucuronosyltransferase (Ugt2b2), mRNA. Length = 1593 14633 1075 NM_031533 H Rattus norvegicus Androsterone UDP- Androsterone UDP- glucuronosyltransferase glucuronosyltransferase (Ugt2b2), mRNA. Length = 1593 14347 1075 NM_031533 H Rattus norvegicus Rat UDP-glucuronosyltransferase mRNA, Androsterone UDP- complete cds glucuronosyltransferase (Ugt2b2), mRNA. Length = 1593 17805 1117 NM_031980 B Rattus norvegicus UDP- UDP-glucuronosyltransferase glucuronosyltransferase (Ugt2b12), mRNA. Length = 1846 1537 1216 U27518 H Rattus norvegicus UDP- glucuronosyltransferase mRNA, complete cds 15926 1150 NM_053607 D Rattus norvegicus long-chain long-chain fatty acid coenzyme A ligase 5 fatty acid coenzyme A ligase 5 (Facl5), mRNA. Length = 2454 18246 1003 NM_022300 B, F Rattus norvegicus brain brain acidic membrane protein acidic membrane protein (Basp1), mRNA. Length = 1024 23625 969 NM_019269 D Rattus norvegicus solute solute carrier family 22 (organic cation carrier family 22 (organic transporter), member 5 cation transporter), member 5 (Slc22a5), mRNA. Length = 3037 6416 1136 NM_053380 GENERAL, K Rattus norvegicus solute solute carrier family 34 (sodium carrier family 34 (sodium phosphate), member 2 phosphate), member 2 (Slc34a2), mRNA. Length = 3950 14978 622 AI177386 F Protein tyrosine Protein tyrosine phosphatase, receptor phosphatase, receptor type, D type, D 1798 261 AA945569 GENERAL, D R. norvegicus alpha-1-macroglobulin mRNA, complete cds 21977 1133 NM_053329 A, B Rattus norvegicus insulin-like insulin-like growth factor binding protein, growth factor binding protein, acid labile subunit acid labile subunit (Igfals), mRNA. Length = 1812 8426 338 AF036335 E, F Rattus norvegicus NonO/p54nrb homolog mRNA, partial cds 22219 972 NM_019286 F Rattus norvegicus Alcohol Alcohol dehydrogenase (class I), alpha dehydrogenase 3 (Adh3), polypeptide mRNA. Length = 1131 1650 34 AA817825 A Peptidylglycine alpha- Peptidylglycine alpha-amidating amidating monooxygenase monooxygenase 1644 121 AA891068 A, F Peptidylglycine alpha- Peptidylglycine alpha-amidating amidating monooxygenase monooxygenase 1649 518 AI103782 F Peptidylglycine alpha- Peptidylglycine alpha-amidating amidating monooxygenase monooxygenase 1651 651 AI228068 A, H Peptidylglycine alpha- Peptidylglycine alpha-amidating amidating monooxygenase monooxygenase 1652 665 AI229728 A Peptidylglycine alpha- Peptidylglycine alpha-amidating amidating monooxygenase monooxygenase 1653 719 AI233806 A Peptidylglycine alpha- Peptidylglycine alpha-amidating amidating monooxygenase monooxygenase 15051 741 AI236332 GENERAL ESTs, Highly similar to S43429 diamine N-acetyltransferase (EC 2.3.1.57) - mouse [ M. musculus ] 3430 897 NM_013156 GENERAL, Rattus norvegicus Cathepsin Cathepsin L G, I L (Ctsl), mRNA. Length = 1386 10378 709 AI233300 A ESTs, Moderately similar to CO5_MOUSE Complement C5 precursor (Hemolytic complement) [Contains: C5A anaphylatoxin] [ M. musculus ] 20832 268 AA946040 A ESTs, Highly similar to COXG_MOUSE Cytochrome c oxidase polypeptide VIb (AED) [ M. musculus ] 20833 524 AI104035 A ESTs, Highly similar to COXG_MOUSE Cytochrome c oxidase polypeptide VIb (AED) [ M. musculus ] 15411 1078 NM_031559 B, L Rattus norvegicus Carnitine Carnitine palmitoyltransferase 1 alpha, palmitoyltransferase 1 alpha, liver isoform liver isoform (Cpt1a), mRNA. Length = 4377 8888 916 NM_017090 B Rattus norvegicus guanylate guanylate cyclase 1, soluble, alpha 3 cyclase 1, soluble, alpha 3 (Gucy1a3), mRNA. Length = 4775 20716 984 NM_019623 G Rattus norvegicus cytochrome P450 4F1 cytochrome P450 4F1 (Cyp4f1), mRNA. Length = 1977 25070 1038 NM_024392 GENERAL Rattus norvegicus peroxisomal multifunctional enzyme type peroxisomal multifunctional II enzyme type II (Hsd17b4), mRNA. Length = 2535 811 1095 NM_031705 GENERAL, I Rattus norvegicus dihydropyrimidinase dihydropyrimidinase (Dpys), mRNA. Length = 2091 812 1095 NM_031705 GENERAL, I Rattus norvegicus dihydropyrimidinase dihydropyrimidinase (Dpys), mRNA. Length = 2091 14083 619 AI177181 C ESTs, Weakly similar to FYV1_MOUSE FYVE finger-containing phosphoinositide kinase (1-phosphatidylinositol-4- phosphate kinase) (PIP5K) (Ptdlns(4)P-5- kinase) (p235) [ M. musculus ] 11421 1190 NM_130405 E Rattus norvegicus src src associated in mitosis, 68 kDa associated in mitosis, 68 kDa (Sam68), mRNA. Length = 2655 2554 873 NM_012967 GENERAL Rattus norvegicus Intercellular adhesion molecule 1 Intercellular adhesion molecule 1 (Icam1), mRNA. Length = 2602 2555 873 NM_012967 GENERAL, Rattus norvegicus Intercellular adhesion molecule 1 C, I Intercellular adhesion molecule 1 (Icam1), mRNA. Length = 2602 16003 1103 NM_031757 C Rattus norvegicus matrix matrix metalloproteinase 24 (membrane- metalloproteinase 24 inserted) (membrane-inserted) (Mmp24), mRNA. Length = 4245 405 1081 NM_031587 GENERAL, Rattus norvegicus peroxisomal membrane protein 2, 22 kDa H, K peroxisomal membrane protein 2, 22 kDa (Pxmp2), mRNA. Length = 852 1475 1115 NM_031971 C Rattus norvegicus Heat ESTs, Highly similar to S10A_RAT S-100 shock protein 70-1 (Hspa1a), protein, alpha chain [ R. norvegicus ], Heat mRNA. Length = 2455 shock protein 70-1 1472 1215 U26356 K ESTs, Highly similar to S10A_RAT S-100 protein, alpha chain [ R. norvegicus ] 9332 694 AI232210 F MIC2 like 1 MIC2 like 1 19031 928 NM_017180 GENERAL, L Rattus norvegicus T-cell T-cell death associated gene death associated gene (Tdag), mRNA. Length = 1353 1511 1137 NM_053424 D Rattus norvegicus solute solute carrier family 4, sodium carrier family 4, sodium bicarbonate cotransporter, member 4 bicarbonate cotransporter, member 4 (Slc4a4), mRNA. Length = 3573 20802 1018 NM_022592 H Rattus norvegicus transketolase transketolase (Tkt), mRNA. Length = 2098 20803 1018 NM_022592 B, H, I Rattus norvegicus transketolase transketolase (Tkt), mRNA. Length = 2098 20804 1018 NM_022592 H Rattus norvegicus transketolase transketolase (Tkt), mRNA. Length = 2098 11843 1143 NM_053555 A Rattus norvegicus vesicle- vesicle-associated membrane protein 5 associated membrane protein 5 (Vamp5), mRNA. Length = 309 4592 979 NM_019356 H Rattus norvegicus eukaryotic eukaryotic translation initiation factor 2, translation initiation factor 2, subunit 1 (alpha) subunit 1 (alpha) (Eif2s1), mRNA. Length = 1377 16948 850 NM_012793 A, C Rattus norvegicus Guanidinoacetate methyltransferase Guanidinoacetate methyltransferase (Gamt), mRNA. Length = 924 18750 940 NM_017257 G Rattus norvegicus protease protease (prosome, macropain) 28 (prosome, macropain) 28 subunit, beta subunit, beta (Psme2), mRNA. Length = 806 18751 940 NM_017257 G Rattus norvegicus protease protease (prosome, macropain) 28 (prosome, macropain) 28 subunit, beta subunit, beta (Psme2), mRNA. Length = 806 12682 1069 NM_031332 D Rattus norvegicus organic organic anion transporter anion transporter (LOC83500), mRNA. Length = 2157 17324 991 NM_021593 GENERAL Rattus norvegicus kynurenine 3-hydroxylase kynurenine 3-hydroxylase (Kmo), mRNA. Length = 1733 5837 893 NM_013143 GENERAL, F Rattus norvegicus Meprin 1 Meprin 1 alpha alpha (Mep1a), mRNA. Length = 2928 5838 893 NM_013143 GENERAL, Rattus norvegicus Meprin 1 Meprin 1 alpha F, G alpha (Mep1a), mRNA. Length = 2928 7690 48 AA818875 GENERAL uroguanylin uroguanylin 1809 274 AA946503 G, K lipocalin 2 lipocalin 2 20740 1197 S69874 D Rattus norvegicus Sprague-Dawley lipid- binding protein mRNA, complete cds 8188 1167 NM_053927 GENERAL Rattus norvegicus erythrocyte protein band 4.1-like 3 erythrocyte membrane protein band 4.1-like 3 (Epb41I3), mRNA. Length = 4543 6782 606 AI176170 B FK506-binding protein 1 FK506-binding protein 1 (12 kD) (12 kD) 15295 887 NM_013102 GENERAL, Rattus norvegicus FK506- FK506-binding protein 1 (12 kD) H, I binding protein 1 (12 kD) (Fkbp1a), mRNA. Length = 554 15296 887 NM_013102 H, I Rattus norvegicus FK506- FK506-binding protein 1 (12 kD) binding protein 1 (12 kD) (Fkbp1a), mRNA. Length = 554 15297 887 NM_013102 K Rattus norvegicus FK506- FK506-binding protein 1 (12 kD) binding protein 1 (12 kD) (Fkbp1a), mRNA. Length = 554 13091 550 AI136977 L ESTs, Highly similar to S14538 transition protein - mouse [ M. musculus ] 13092 689 AI231547 L ESTs, Highly similar to S14538 transition protein - mouse [ M. musculus ] 1143 971 NM_019280 A Rattus norvegicus gap gap junction membrane channel protein junction membrane channel alpha 5 (connexin 40) protein alpha 5 (Gja5), mRNA. Length = 3115 15072 726 AI234969 A GATA-binding protein 4 GATA-binding protein 4 1399 907 NM_017006 GENERAL, Rattus norvegicus Glucose-6- Glucose-6-phosphate dehydrogenase H, I phosphate dehydrogenase (G6pd), mRNA. Length = 2324 14003 948 NM_017305 B, J Rattus norvegicus glutamate- glutamate-cysteine ligase, modifier cysteine ligase, modifier subunit subunit (Gclm), mRNA. Length = 1382 16775 1048 NM_031031 GENERAL, Rattus norvegicus L-arginine: L-arginine: glycine amidinotransferase D, I, L glycine amidinotransferase (Gatm), mRNA. Length = 2260 1551 915 NM_017084 G Rattus norvegicus Glycine Glycine methyltransferase methyltransferase (Gnmt), mRNA. Length = 988 22675 980 NM_019358 G Rattus norvegicus glycoprotein 38 glycoprotein 38 (Gp38), mRNA. Length = 1854 352 1030 NM_024127 H Rattus norvegicus DNA- DNA-damage-inducible transcript 1 damage-inducible transcript 1 (Gadd45a), mRNA. Length = 711 353 1030 NM_024127 GENERAL, Rattus norvegicus DNA- DNA-damage-inducible transcript 1 H, I damage-inducible transcript 1 (Gadd45a), mRNA. Length = 711 354 1030 NM_024127 GENERAL, Rattus norvegicus DNA- DNA-damage-inducible transcript 1 H, I damage-inducible transcript 1 (Gadd45a), mRNA. Length = 711 17524 381 AI010568 GENERAL, Growth hormone receptor Growth hormone receptor A, I 10887 917 NM_017094 GENERAL, I Rattus norvegicus Growth Growth hormone receptor hormone receptor (Ghr), mRNA. Length = 2950 14184 1106 NM_031776 GENERAL Rattus norvegicus guanine guanine deaminase deaminase (Gda), mRNA. Length = 1568 14185 1106 NM_031776 GENERAL Rattus norvegicus guanine guanine deaminase deaminase (Gda), mRNA. Length = 1568 3608 1049 NM_031044 GENERAL, J Rattus norvegicus histamine histamine N-methyltransferase N-methyltransferase (Hnmt), mRNA. Length = 1225 3610 1049 NM_031044 GENERAL, Rattus norvegicus histamine histamine N-methyltransferase G, I, J N-methyltransferase (Hnmt), mRNA. Length = 1225 3609 1203 S82579 F histamine N- histamine N-methyltransferase methyltransferase 1382 332 AB002406 G RuvB-like protein 1 RuvB-like protein 1 15750 1131 NM_053309 H Rattus norvegicus homer, homer, neuronal immediate early gene, 2 neuronal immediate early gene, 2 (Homer2), mRNA. Length = 1994 4944 218 AA924405 GENERAL, ESTs, Weakly similar to NFH_MOUSE H, I, K Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H) [ M. musculus ] 24643 1006 NM_022400 K Rattus norvegicus branched branched chain aminotransferase 2, chain aminotransferase 2, mitochondrial mitochondrial (Bcat2), mRNA. Length = 1548 3941 386 AI011598 GENERAL, J ESTs, Moderately similar to LMA5_MOUSE Laminin alpha-5 chain precursor [ M. musculus ] 20896 1148 NM_053592 A, F Rattus norvegicus dUTPase Deoxyuridinetriphosphatase (dUTPase) (LOC94200), mRNA. Length = 952 457 813 M60666 E, G, K Tropomyosin 1 (alpha) Tropomyosin 1 (alpha) 455 957 NM_019131 E Rattus norvegicus Tropomyosin 1 (alpha) Tropomyosin 1 (alpha) (Tpm1), mRNA. Length = 1004 16681 920 NM_017136 B, L Rattus norvegicus squalene squalene epoxidase epoxidase (Sqle), mRNA. Length = 2199 24900 925 NM_017163 H Rattus norvegicus X X transporter protein 2 transporter protein 2 (Xtrp2), mRNA. Length = 2336 7300 1070 NM_031341 C Rattus norvegicus solute solute carrier family 7 (cationic amino carrier family 7 (cationic acid transporter, y+system), member 7 amino acid transporter, y+system), member 7 (Slc7a7), mRNA. Length = 2077 3615 754 AI237645 J transferrin receptor transferrin receptor 20884 857 NM_012842 G, K Rattus norvegicus Epidermal Epidermal growth factor growth factor (Egf), mRNA. Length = 4801 20885 857 NM_012842 G, K Rattus norvegicus Epidermal Epidermal growth factor growth factor (Egf), mRNA. Length = 4801 23748 566 AI169037 F ESTs, Highly similar to MPU1_MOUSE Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) (SL15) [ M. musculus ] 21211 1023 NM_022607 C Rattus norvegicus MIPP65 MIPP65 protein protein (Mipp65), mRNA. Length = 1468 15599 938 NM_017236 J Rattus norvegicus phosphatidylethanolamine binding protein phosphatidylethanolamine binding protein (Pbp), mRNA. Length = 1075 1247 792 J05181 J Glutamylcysteine gamma Glutamylcysteine gamma synthetase light synthetase light chain chain 15662 1065 NM_031318 G Rattus norvegicus t-complex t-complex testis expressed 1 testis expressed 1 (Tctex1), mRNA. Length = 698 15663 1065 NM_031318 GENERAL Rattus norvegicus t-complex t-complex testis expressed 1 testis expressed 1 (Tctex1), mRNA. Length = 698 20960 1020 NM_022598 D Rattus norvegicus cellular cellular nucleic acid binding protein nucleic acid binding protein (Cnbp), mRNA. Length = 1640 729 819 M95762 D solute carrier family 6 solute carrier family 6 (neurotransmitter (neurotransmitter transporter, transporter, GABA), member 13 GABA), member 13 15175 1091 NM_031682 E Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase hydroxyacyl-Coenzyme A 10 dehydrogenase, type II (Hadh2), mRNA. Length = 917 275 914 NM_017081 GENERAL Rattus norvegicus Hydroxysteroid dehydrogenase, 11 beta Hydroxysteroid type 2 dehydrogenase, 11 beta type 2 (Hsd11b2), mRNA. Length = 1864 2059 565 AI146005 A, H HMm: pseudouridine ESTs, Highly similar to TRUA_MOUSE synthase 1 tRNA pseudouridine synthase A (Pseudouridylate synthase I) (Pseudouridine synthase I) (Uracil hydrolyase) [ M. musculus ] 16982 894 NM_013144 GENERAL, Rattus norvegicus Insulin-like Insulin-like growth factor binding protein 1 B, L growth factor binding protein 1 (Igfbp1), mRNA. Length = 1500 14989 621 AI177366 GENERAL, K Integrin, beta 1 Integrin, beta 1 1729 961 NM_019147 B Rattus norvegicus jagged 1 jagged 1 (Jag1), mRNA. Length = 5575 22352 603 AI175959 GENERAL, H Avian sarcoma virus 17 (v- Avian sarcoma virus 17 (v-jun) oncogene jun) oncogene homolog homolog 5384 120 AA891041 I jun B proto-oncogene jun B proto-oncogene 20161 998 NM_021836 GENERAL, Rattus norvegicus Jun B jun B proto-oncogene C, I proto-oncogene (Junb), mRNA. Length = 1035 16726 1112 NM_031855 GENERAL, Rattus norvegicus Ketohexokinase E, G, H, I Ketohexokinase (Khk), mRNA. Length = 1342 15761 345 AF062741 B Rattus norvegicus pyruvate dehydrogenase phosphatase isoenzyme 2 mRNA, complete cds 24631 1032 NM_024137 F Rattus norvegicus human human immunodeficiency virus type I immunodeficiency virus type enhancer-binding protein 2 I enhancer-binding protein 2 (Hivep2), mRNA. Length = 9731 1850 840 NM_012696 GENERAL Rattus norvegicus T- T-kininogen, see also D11Elh1 and kininogen, see also D11Elh1 D11Mit8 and D11Mit8 (Kng), mRNA. Length = 1417 25379 1156 NM_053713 GENERAL, C Rattus norvegicus Kruppel- Kruppel-like factor 4 (gut) like factor 4 (gut) (Klf4), mRNA. Length = 2393 17807 909 NM_017025 GENERAL, G Rattus norvegicus Lactate Lactate dehydrogenase A dehydrogenase A (Ldha), mRNA. Length = 1609 7124 829 NM_012595 E Rattus norvegicus Lactate Lactate dehydrogenease B dehydrogenease B (Ldhb), mRNA. Length = 1217 410 358 AI008974 GENERAL, E low density lipoprotein low density lipoprotein receptor-related receptor-related protein protein associated protein 1 associated protein 1 409 695 AI232268 GENERAL, I low density lipoprotein low density lipoprotein receptor-related receptor-related protein protein associated protein 1 associated protein 1 408 1169 NM_053961 GENERAL Rattus norvegicus low density lipoprotein receptor-related endoplasmic retuclum protein protein associated protein 1 29 (Erp29), mRNA. Length = 4529 406 1259 Z11995 GENERAL low density lipoprotein low density lipoprotein receptor-related receptor-related protein protein associated protein 1 associated protein 1 407 1259 Z11995 C low density lipoprotein low density lipoprotein receptor-related receptor-related protein protein associated protein 1 associated protein 1 15242 964 NM_019191 D Rattus norvegicus MAD MAD homolog 2 ( Drosophila ) homolog 2 ( Drosophila ) (Madh2), mRNA. Length = 2113 21122 1242 X56228 E Thiosulfate Thiosulfate sulphurtransferase sulphurtransferase (rhodanese) (rhodanese) 21123 1242 X56228 D Thiosulfate Thiosulfate sulphurtransferase sulphurtransferase (rhodanese) (rhodanese) 19152 768 AI639387 GENERAL, D ESTs, Highly similar to RT06_MOUSE Mitochondrial 28S ribosomal protein S6 (MRP-S6) [ M. musculus ] 3925 75 AA851017 A, E ESTs, Highly similar to molybdenum cofactor synthesis 2 [ Mus musculus ] [ M. musculus ] 809 1207 U17035 C small inducible cytokine B small inducible cytokine B subfamily (Cys- subfamily (Cys-X-Cys), X-Cys), member 10 member 10 17223 605 AI176140 D ESTs, Highly similar to testis expressed gene 189 [ Mus musculus ] [ M. musculus ] 1462 733 AI235585 GENERAL, cathepsin D cathepsin D E, G 1463 1241 X54467 GENERAL, cathepsin D cathepsin D G, K 16610 781 D28557 E, L cold shock domain protein A cold shock domain protein A 23810 402 AI012781 E ESTs, Highly similar to EZH2_MOUSE Enhancer of zeste homolog 2 (ENX-1) [ M. musculus ] 19824 995 NM_021750 G, K Rattus norvegicus cysteine- cysteine-sulfinate decarboxylase sulfinate decarboxylase (Csad), mRNA. Length = 2413 6577 1011 NM_022532 F Rattus norvegicus A-raf A-raf (Araf1), mRNA. Length = 2288 22781 111 AA874926 F ESTs, Weakly similar to dual-specificity phosphatase [ Mus musculus ] [ M. musculus ] 22783 205 AA894207 A, F ESTs, Weakly similar to dual-specificity phosphatase [ Mus musculus ] [ M. musculus ] 23093 217 AA924342 G ESTs, Weakly similar to dual-specificity phosphatase [ Mus musculus ] [ M. musculus ] 15790 1135 NM_053341 E Rattus norvegicus regulator regulator of G-protein signaling 19 of G-protein signaling 19 (Rgs19), mRNA. Length = 1607 15791 1135 NM_053341 C Rattus norvegicus regulator regulator of G-protein signaling 19 of G-protein signaling 19 (Rgs19), mRNA. Length = 1607 24484 1128 NM_052806 H Rattus norvegicus Acetylcholine receptor beta 4 Acetylcholine receptor beta 4 (Chrnb4), mRNA. Length = 2461 19184 631 AI178025 GENERAL, ESTs, Highly similar to TGIF_MOUSE 5′- H, I TG-3′ INTERACTING FACTOR (HOMEOBOX PROTEIN TGIF) [ M. musculus ] 35 1162 NM_053840 C Rattus norvegicus gamma- gamma-glutamyl transpeptidase glutamyl transpeptidase (M33821), mRNA. Length = 2141 699 1223 U55765 E serine (or cysteine) serine (or cysteine) proteinase inhibitor, proteinase inhibitor, clade A clade A (alpha-1 antiproteinase, (alpha-1 antiproteinase, antitrypsin), member 10 antitrypsin), member 10 24582 939 NM_017243 D Rattus norvegicus phosphoribosyl pyrophosphate phosphoribosyl synthetase 1 pyrophosphate synthetase 1 (Prps1), mRNA. Length = 1981 23698 821 NM_012489 D Rattus norvegicus Acetyl- Acetyl-CoA acyltransferase, 3-oxo acyl- CoA acyltransferase, 3-oxo CoA thiolase A 1, peroxisomal acyl-CoA thiolase A, peroxisomal (Acaa), mRNA. Length = 1619 23699 821 NM_012489 D, E Rattus norvegicus Acetyl- Acetyl-CoA acyltransferase, 3-oxo acyl- CoA acyltransferase, 3-oxo CoA thiolase A 1, peroxisomal acyl-CoA thiolase A, peroxisomal (Acaa), mRNA. Length = 1619 16884 517 AI103758 E aldehyde dehydrogenase aldehyde dehydrogenase family 9, family 9, subfamily A1 subfamily A1 16885 531 AI105188 K aldehyde dehydrogenase aldehyde dehydrogenase family 9, family 9, subfamily A1 subfamily A1 21695 1191 NM_130411 G Rattus norvegicus coronin, coronin, actin binding protein 1A actin binding protein 1A (Coro1a), mRNA. Length = 1386 19058 342 AF054618 E cortactin isoform B cortactin isoform B 3454 1155 NM_053662 J Rattus norvegicus cyclin L cyclin L (Ccnl), mRNA. Length = 2092 794 1166 NM_053902 GENERAL, I Rattus norvegicus kynureninase (L-kynurenine hydrolase) kynureninase (L-kynurenine hydrolase) (Kynu), mRNA. Length = 1765 1929 1045 NM_030872 A, C, D, E Rattus norvegicus pyruvate pyruvate dehydrogenase kinase 2 subunit dehydrogenase kinase 2 p45 (PDK2) subunit p45 (PDK2) (Pdk2), mRNA. Length = 2207 18502 1118 NM_031984 G, J Rattus norvegicus cerebellar cerebellar Ca-binding protein, spot 35 Ca-binding protein, spot 35 protein protein (Calb1), mRNA. Length = 2280 18503 1118 NM_031984 G Rattus norvegicus cerebellar cerebellar Ca-binding protein, spot 35 Ca-binding protein, spot 35 protein protein (Calb1), mRNA. Length = 2280 5496 1083 NM_031589 GENERAL, Rattus norvegicus glucose-6- glucose-6-phosphatase, transport protein 1 D, E phosphatase, transport protein 1 (G6pt1), mRNA. Length = 1930 5497 1083 NM_031589 GENERAL, Rattus norvegicus glucose-6- glucose-6-phosphatase, transport protein 1 D, E phosphatase, transport protein 1 (G6pt1), mRNA. Length = 1930 14970 1059 NM_031127 GENERAL, Rattus norvegicus sulfite sulfite oxidase B, H, I, K oxidase (Suox), mRNA. Length = 1777 2629 830 NM_012603 K Rattus norvegicus Avian Avian myelocytomatosis viral (v-myc) myelocytomatosis viral (v- oncogene homolog myc) oncogene homolog (Myc), mRNA. Length = 2168 21302 404 AI013297 J HMm: NADH dehydrogenase ESTs, Moderately similar to NADH (ubiquinone) Fe—S protein 4 dehydrogenase (ubiquinone) Fe—S protein 4; NADH dehydrogenase (ubiquinone) Fe—S protein 4 (18 kDa) [ Mus musculus ] [ M. musculus ] 14638 551 AI137049 J nibrin nibrin 1508 1163 NM_053845 G Rattus norvegicus ureidopropionase, beta ureidopropionase, beta (Upb1), mRNA. Length = 1420 1401 1152 NM_053616 J Rattus norvegicus preimplantation protein 2 preimplantation protein 2 (Prei2), mRNA. Length = 2412 14332 775 AJ001044 D tumor-associated calcium tumor-associated calcium signal signal transducer 1 transducer 1 20457 986 NM_020073 GENERAL, Rattus norvegicus parathyroid hormone receptor B, K, L parathyroid hormone receptor (LOC56813), mRNA. Length = 2065 20458 986 NM_020073 GENERAL, Rattus norvegicus parathyroid hormone receptor I, K, L parathyroid hormone receptor (LOC56813), mRNA. Length = 2065 4290 1141 NM_053487 L Rattus norvegicus peroxisomal membrane protein Pmp26p peroxisomal membrane (Peroxin-11) protein Pmp26p (Peroxin-11) (Pex11a), mRNA. Length = 1194 21976 266 AA946011 B phosphatidylinositol-4- phosphatidylinositol-4-phosphate 5- phosphate 5-kinase, type II, kinase, type II, gamma gamma 5295 240 AA926247 GENERAL, L putative potassium channel putative potassium channel TWIK TWIK 19665 993 NM_021688 D, L Rattus norvegicus putative putative potassium channel TWIK potassium channel TWIK (Kcnk1), mRNA. Length = 1582 24566 833 NM_012630 B, F, L Rattus norvegicus Prolactin Prolactin receptor receptor (Prlr), mRNA. Length = 1635 24567 833 NM_012630 F Rattus norvegicus Prolactin Prolactin receptor receptor (Prlr), mRNA. Length = 1635 24568 833 NM_012630 GENERAL, B Rattus norvegicus Prolactin Prolactin receptor receptor (Prlr), mRNA. Length = 1635 11454 1004 NM_022381 GENERAL Rattus norvegicus Proliferating cell nuclear antigen Proliferating cell nuclear antigen (Pcna), mRNA. Length = 1160 11455 1004 NM_022381 GENERAL Rattus norvegicus Proliferating cell nuclear antigen Proliferating cell nuclear antigen (Pcna), mRNA. Length = 1160 19469 146 AA892112 GENERAL, D ESTs, Weakly similar to PROD_MOUSE PROLINE OXIDASE, MITOCHONDRIAL PRECURSOR (PROLINE DEHYDROGENASE) [ M. musculus ] 1422 1066 NM_031324 GENERAL, Rattus norvegicus prolyl prolyl endopeptidase B, G, L endopeptidase (Prep), mRNA. Length = 2743 15470 1116 NM_031978 H Rattus norvegicus 26S 26S proteasome, subunit p112 proteasome, subunit p112 (PSMD1), mRNA. Length = 3089 3254 945 NM_017282 L Rattus norvegicus proteasome (prosome, macropain) proteasome (prosome, subunit, alpha type 5 macropain) subunit, alpha type 5 (Psma5), mRNA. Length = 970 25253 1173 NM_057099 H Rattus norvegicus proteasome (prosome, macropain) proteasome (prosome, subunit, beta type 6 macropain) subunit, beta type 6 (Psmb6), mRNA. Length = 760 24219 1079 NM_031579 GENERAL, L Rattus norvegicus protein protein tyrosine phosphatase 4a1 tyrosine phosphatase 4a1 (Ptp4a1), mRNA. Length = 2638 25198 996 NM_021754 GENERAL, Rattus norvegicus Nopp140 Nopp140 associated protein I, K associated protein (Nap65), mRNA. Length = 1980 20035 996 NM_021754 GENERAL, H Rattus norvegicus Nopp140 Nopp140 associated protein associated protein (Nap65), mRNA. Length = 1980 4661 207 AA899709 GENERAL, receptor activity modifying receptor activity modifying protein 3 B, L protein 3 28 1077 NM_031546 GENERAL, Rattus norvegicus Regucalcin F, G, I, J, L Regucalcin (Rgn), mRNA. Length = 1605 1515 1053 NM_031095 J Rattus norvegicus renin- renin-binding protein binding protein (Renbp), mRNA. Length = 1292 10789 1039 NM_024399 GENERAL Rattus norvegicus aspartoacylase aspartoacylase (Aspa), mRNA. Length = 1552 18452 913 NM_017074 GENERAL Rattus norvegicus CTL target CTL target antigen antigen (Cth), mRNA. Length = 1743 18453 913 NM_017074 G Rattus norvegicus CTL target CTL target antigen antigen (Cth), mRNA. Length = 1743 18001 79 AA858573 GENERAL spp-24 precursor spp-24 precursor 17999 1211 U19485 GENERAL spp-24 precursor spp-24 precursor 18000 1211 U19485 I spp-24 precursor spp-24 precursor 1549 1009 NM_022508 G Rattus norvegicus C1- C1-tetrahydrofolate synthase tetrahydrofolate synthase (LOC64300), mRNA. Length = 3332 15800 1159 NM_053810 A Rattus norvegicus synaptosomal-associated protein, 29 kD synaptosomal-associated protein, 29 kD (Snap29), mRNA. Length = 774 25467 818 M93297 G ornithine aminotransferase ornithine aminotransferase 21253 530 AI105110 F ESTs, Highly similar to S58180 sui1 protein - mouse (fragment) [ M. musculus ] 23884 1099 NM_031731 J Rattus norvegicus alcohol alcohol dehydrogenase family 3, dehydrogenase family 3, subfamily A2 subfamily A2 (Aldh3a2), mRNA. Length = 2977 12921 546 AI112636 GENERAL, HMm: uridine phosphorylase ESTs, Highly similar to A57501 uridine B, L phosphorylase (EC 2.4.2.3) I - mouse [ M. musculus ] 20809 951 NM_017326 D Rattus norvegicus calmodulin Calmodulin 2 (phosphorylase kinase, (RCM3), mRNA. Length = 1112 delta) 25802 1113 NM_031969 G, K Rattus norvegicus Calmodulin 1 (phosphorylase kinase, Calmodulin 1 (phosphorylase delta) kinase, delta) (Calm1), mRNA. Length = 3513 3878 193 AA893230 GENERAL ESTs, Weakly similar to CALM_HUMAN Calmodulin [ R. norvegicus ] 24233 308 AA964756 F ESTs, Weakly similar to CALM_HUMAN Calmodulin [ R. norvegicus ] 16168 194 AA893280 GENERAL, J ESTs, Moderately similar to ADFP_MOUSE ADIPOPHILIN (ADIPOSE DIFFERENTIATION- RELATED PROTEIN) (ADRP) [ M. musculus ] 16169 430 AI030932 J ESTs, Moderately similar to ADFP_MOUSE ADIPOPHILIN (ADIPOSE DIFFERENTIATION- RELATED PROTEIN) (ADRP) [ M. musculus ] 3172 317 AA997406 B ESTs, Highly similar to PSA7_RAT Proteasome subunit alpha type 7 (Proteasome subunit RC6-1) [ R. norvegicus ] 13157 558 AI138020 D ESTs, Weakly similar to S43429 diamine N-acetyltransferase (EC 2.3.1.57) - mouse [ M. musculus ] 7700 534 AI105383 GENERAL, D sphingosine kinase 1 sphingosine kinase 1 1847 834 NM_012634 B Rattus norvegicus Phophoribosylpyrophosphate synthetase, Phophoribosylpyrophosphate subunit II synthetase, subunit II (Prps2), mRNA. Length = 2697 2098 20 AA799995 C ribosomal protein L14 ribosomal protein L14 16227 960 NM_019137 F Rattus norvegicus Zinc-finger Zinc-finger transcription factor NGFI-C transcription factor NGFI-C (early response gene) (early response gene) (Egr4I1), mRNA. Length = 2145 23166 100 AA859954 GENERAL, Vacuole Membrane Protein 1 Vacuole Membrane Protein 1 C, L 18354 1246 X59859 J decorin decorin 18352 1260 Z12298 L decorin decorin 16552 1169 NM_053961 L Rattus norvegicus endoplasmic retuclum protein 29 endoplasmic retuclum protein 29 (Erp29), mRNA. Length = 4529 4280 672 AI230247 F selenoprotein P, plasma, 1 selenoprotein P, plasma, 1 17088 142 AA891998 B, L ESTs, Highly similar to JC4978 oxidative stress protein A170 - mouse [ M. musculus ] 17301 926 NM_017173 E, I Rattus norvegicus serine serine proteinase inhibitor, clade H (heat proteinase inhibitor, clade H shock protein 47), member 1 (heat shock protein 47), member 1 (Serpinh1), mRNA. Length = 2063 1214 1102 NM_031741 GENERAL, K Rattus norvegicus solute solute carrier family 2 (facilitated glucose carrier family 2 (facilitated transporter), member 5 glucose transporter), member 5 (Slc2a5), mRNA. Length = 2169 17468 165 AA892545 D ESTs, Moderately similar to organic cationic transporter-like 2 [ Mus musculus ] [ M. musculus ] 23509 383 AI010962 A ESTs, Highly similar to SNX3_MOUSE Sorting nexin 3 (SDP3 protein) [ M. musculus ] 15393 581 AI170663 J HHs: sterol regulatory ESTs, Weakly similar to A48085 element binding transcription transcription factor ADD1 - rat factor 2 [ R. norvegicus ] 11692 758 AI638982 GENERAL sulfotransferase family, sulfotransferase family, cytosolic, 1C, cytosolic, 1C, member 2 member 2 494 861 NM_012880 J Rattus norvegicus Superoxide dismutase 3 Superoxide dismutase 3 (Sod3), mRNA. Length = 1729 495 861 NM_012880 J Rattus norvegicus Superoxide dismutase 3 Superoxide dismutase 3 (Sod3), mRNA. Length = 1729 24821 1158 NM_053788 J Rattus norvegicus syntaxin 1 syntaxin 1 a a (Stx1a), mRNA. Length = 871 7489 963 NM_019169 GENERAL, Rattus norvegicus synuclein, synuclein, alpha G, I, J, L alpha (Snca), mRNA. Length = 1018 3407 322 AA997953 F TCF3 (E2A) fusion partner TCF3 (E2A) fusion partner (in childhood (in childhood leukemia) leukemia) 24234 1086 NM_031614 GENERAL, Rattus norvegicus thioredoxin reductase 1 A, I thioredoxin reductase 1 (Txnrd1), mRNA. Length = 3360 24235 1086 NM_031614 GENERAL, Rattus norvegicus thioredoxin reductase 1 H, I thioredoxin reductase 1 (Txnrd1), mRNA. Length = 3360 17234 507 AI102741 J Tissue inhibitor of Tissue inhibitor of metalloproteinase 3 metalloproteinase 3 15004 729 AI235224 GENERAL, tissue inhibitor of tissue inhibitor of metalloproteinase 1 G, K metalloproteinase 1 15002 1160 NM_053819 GENERAL, Rattus norvegicus tissue tissue inhibitor of metalloproteinase 1 E, G, K inhibitor of metalloproteinase 1 (Timp1), mRNA. Length = 740 15003 1160 NM_053819 G, K Rattus norvegicus tissue tissue inhibitor of metalloproteinase 1 inhibitor of metalloproteinase 1 (Timp1), mRNA. Length = 740 16039 1107 NM_031811 H Rattus norvegicus transaldolase 1 transaldolase 1 (Taldo1), mRNA. Length = 1057 7505 1013 NM_022534 A Rattus norvegicus transcobalamin II precursor transcobalamin II precursor (Tcn2p), mRNA. Length = 1808 1885 888 NM_013103 GENERAL Rattus norvegicus Transcription factor 2, hepatic; LF-B3; Transcription factor 2, variant hepatic nuclear factor hepatic; LF-B3; variant hepatic nuclear factor (Tcf2), mRNA. Length = 2328 2125 502 AI102519 G ESTs, Highly similar to TYRO protein tyrosine kinase binding protein; killer cell activating receptor associated protein [ Mus musculus ] [ M. musculus ] 15124 1175 NM_057105 B Rattus norvegicus UDP UDP glycosyltransferase 1 family, glycosyltransferase 1 family, polypeptide A6, UDP glycosyltransferase polypeptide A6 (Ugt1a6), 1 family, polypeptide A7, UDP- mRNA. Length = 1593 glucuronosyltransferase 1 family, member 1 15125 1175 NM_057105 B Rattus norvegicus UDP UDP glycosyltransferase 1 family, glycosyltransferase 1 family, polypeptide A6, UDP glycosyltransferase polypeptide A6 (Ugt1a6), 1 family, polypeptide A7 mRNA. Length = 1593 10241 1101 NM_031740 C, K Rattus norvegicus UDP- UDP-Gal: betaGlcNAc beta 1,4- Gal: betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 galactosyltransferase, polypeptide 6 (B4galt6), mRNA. Length = 5729 18597 1067 NM_031325 B, H Rattus norvegicus UDP- UDP-glucose dehydrogeanse glucose dehydrogeanse (Ugdh), mRNA. Length = 2318 20443 982 NM_019379 H Rattus norvegicus vesicle vesicle docking protein, 115 kDa docking protein, 115 kDa (Vdp), mRNA. Length = 3842 12331 1180 NM_057155 GENERAL, H Rattus norvegicus X-prolyl X-prolyl aminopeptidase (aminopeptidase aminopeptidase P) 2, membrane-bound (aminopeptidase P) 2, membrane-bound (Xpnpep2), mRNA. Length = 2828 12332 1180 NM_057155 GENERAL, G Rattus norvegicus X-prolyl X-prolyl aminopeptidase (aminopeptidase aminopeptidase P) 2, membrane-bound (aminopeptidase P) 2, membrane-bound (Xpnpep2), mRNA. Length = 2828 15008 340 AF038591 E cytoplasmic aminopeptidase P cytoplasmic aminopeptidase P 17695 704 AI232784 E ESTs, Weakly similar to S11021 2,4- dienoyl-CoA reductase (NADPH) (EC 1.3.1.34) - rat [ R. norvegicus ] 3279 512 AI103224 F Rattus norvegicus mRNA for carbonyl reductase/NADP-retinol dehydrogenase, complete cds 4462 105 AA866264 GENERAL, ESTs, Weakly similar to PE2R_RAT 20- A, C, I alpha-hydroxysteroid dehydrogenase (20- alpha-HSD) (HSD1) [ R. norvegicus ] 4463 135 AA891831 GENERAL, ESTs, Weakly similar to PE2R_RAT 20- A, I alpha-hydroxysteroid dehydrogenase (20- alpha-HSD) (HSD1) [ R. norvegicus ] 21585 1087 NM_031620 D Rattus norvegicus 3- 3-phosphoglycerate dehydrogenase phosphoglycerate dehydrogenase (Phgdh), mRNA. Length = 1803 21586 1087 NM_031620 D Rattus norvegicus 3- 3-phosphoglycerate dehydrogenase phosphoglycerate dehydrogenase (Phgdh), mRNA. Length = 1803 21587 1087 NM_031620 D Rattus norvegicus 3- 3-phosphoglycerate dehydrogenase phosphoglycerate dehydrogenase (Phgdh), mRNA. Length = 1803 22537 175 AA892799 GENERAL, HMm: glyoxylate ESTs, Weakly similar to 3- A, D reductase/hydroxypyruvate phosphoglycerate dehydrogenase [ Rattus reductase norvegicus ] [ R. norvegicus ] 22538 175 AA892799 GENERAL, D HMm: glyoxylate ESTs, Weakly similar to 3- reductase/hydroxypyruvate phosphoglycerate dehydrogenase [ Rattus reductase norvegicus ] [ R. norvegicus ] 22539 175 AA892799 GENERAL HMm: glyoxylate ESTs, Weakly similar to 3- reductase/hydroxypyruvate phosphoglycerate dehydrogenase [ Rattus reductase norvegicus ] [ R. norvegicus ] 22540 221 AA924630 E HMm: glyoxylate ESTs, Weakly similar to 3- reductase/hydroxypyruvate phosphoglycerate dehydrogenase [ Rattus reductase norvegicus ] [ R. norvegicus ] 347 1205 U01914 D A kinase anchor protein 8 A kinase anchor protein 8 21696 1034 NM_024152 C Rattus norvegicus ADP- ADP-ribosylation factor 6 ribosylation factor 6 (Arf6), mRNA. Length = 995 11968 597 AI172208 F ESTs, Weakly similar to FETA_RAT Alpha-fetoprotein precursor (Alpha- fetoglobulin) (Alpha-1-fetoprotein) [ R. norvegicus ] 4749 1110 NM_031834 L Rattus norvegicus Aryl sulfotransferase cytosolic, 1A, sulfotransferase family 1A, phenol-preferring, member 3, phenol-preferring, member 1 sulfotransferase family 1A, phenol- (Sult1a1), mRNA. Length = 1227 preferring, member 1 22662 725 AI234939 GENERAL ATPase, H+ transporting, ATPase, H+ transporting, lysosomal lysosomal (vacuolar proton (vacuolar proton pump), subunit 1 pump), subunit 1 20841 1084 NM_031604 H Rattus norvegicus ATPase, ATPase, H+ transporting, lysosomal H+ transporting, lysosomal (vacuolar proton pump) noncatalytic (vacuolar proton pump) accessory protein 1 (110/160 kDa) noncatalytic accessory protein 1 (110/160 kDa) (Atp6n1), mRNA. Length = 3876 19 941 NM_017258 GENERAL Rattus norvegicus B-cell B-cell translocation gene 1, anti- translocation gene 1, anti- proliferative proliferative (Btg1), mRNA. Length = 1464 556 851 NM_012803 GENERAL Rattus norvegicus Protein C Protein C (Proc), mRNA. Length = 1543 17836 198 AA893626 D ESTs, Weakly similar to guanine nucleotide-binding protein, beta-1# subunit [ Rattus norvegicus ] [ R. norvegicus ] 17550 387 AI011607 GENERAL, I epsilon-trimethyllysine epsilon-trimethyllysine hydroxylase hydroxylase 17249 137 AA891858 K ESTs, Weakly similar to cadherin 17 [ Rattus norvegicus ] [ R. norvegicus ] 24437 931 NM_017190 A Rattus norvegicus Myelin- Myelin-associated glycoprotein associated glycoprotein (Mag), mRNA. Length = 2474 6635 68 AA849786 GENERAL ESTs, Weakly similar to CLK3_RAT Protein kinase CLK3 (CDC-like kinase 3) [ R. norvegicus ] 15237 773 AI639535 J ESTs, Weakly similar to transporter-like protein [ Rattus norvegicus ] [ R. norvegicus ] 108 797 L14002 J Rattus norvegicus clone 15 polymeric immunoglobulin receptor mRNA, 3′UTR microsatellite repeats 3572 325 AA998516 E HHs: cyclin A2 ESTs, Weakly similar to CGB1_RAT G2/mitotic-specific cyclin B1 [ R. norvegicus ] 22612 262 AA945624 GENERAL, I ESTs, Weakly similar to A34162 NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2) - rat [ R. norvegicus ] 1949 1212 U19614 A Rattus norvegicus lamina associated polypeptide 1C (LAP1C) mRNA, complete cds, Rattus norvegicus lamina- associated polypeptide 1C (LAP1C) mRNA, complete cds 7307 736 AI235935 G, K ESTs, Weakly similar to C1TC_RAT C-1- tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase; Formyltetrahydrofolate synthetase] [ R. norvegicus ] 1824 1210 U17971 K protein tyrosine phosphatase protein tyrosine phosphatase 2E 2E 1727 1088 NM_031642 GENERAL Rattus norvegicus core core promoter element binding protein promoter element binding protein (Copeb), mRNA. Length = 1356 17535 1108 NM_031816 E Rattus norvegicus retinoblastoma binding protein 7 retinoblastoma binding protein 7 (Rbbp7), mRNA. Length = 1947 2912 373 AI010220 GENERAL, ESTs, Weakly similar to CLD7_RAT A, F CLAUDIN-7 [ R. norvegicus ] 22648 636 AI178996 A ESTs, Weakly similar to K2C8_RAT Keratin, type II cytoskeletal 8 (Cytokeratin 8) (Cytokeratin endo A) [ R. norvegicus ] 1460 1199 S76054 GENERAL, ESTs, Highly similar to K2C8_RAT A, C, I, K Keratin, type II cytoskeletal 8 (Cytokeratin 8) (Cytokeratin endo A) [ R. norvegicus ] 16521 379 AI010470 B, J, L Ceruloplasmin (ferroxidase) Ceruloplasmin (ferroxidase) 16520 823 NM_012532 GENERAL, Rattus norvegicus Ceruloplasmin (ferroxidase) B, C, L Ceruloplasmin (ferroxidase) (Cp), mRNA. Length = 3700 14484 628 AI177867 GENERAL ESTs, Weakly similar to intersectin (SH3 domain protein 1A) [ Rattus norvegicus ] [ R. norvegicus ] 10667 742 AI236366 C siah binding protein 1; FBP siah binding protein 1; FBP interacting interacting repressor; repressor; pyrimidine tract binding pyrimidine tract binding splicing factor; Ro ribonucleoprotein- splicing factor; Ro binding protein 1 ribonucleoprotein-binding protein 1 21796 392 AI012221 GENERAL, K ESTs, Weakly similar to intracellular chloride ion channel protein p64H1 [ Rattus norvegicus ] [ R. norvegicus ] 21797 488 AI072439 G, K ESTs, Weakly similar to intracellular chloride ion channel protein p64H1 [ Rattus norvegicus ] [ R. norvegicus ] 12606 1016 NM_022547 E, K Rattus norvegicus 10- 10-formyltetrahydrofolate dehydrogenase formyltetrahydrofolate dehydrogenase (Fthfd), mRNA. Length = 3109 7101 839 NM_012679 GENERAL, E Rattus norvegicus Clusterin Clusterin (Clu), mRNA. Length = 1638 20831 1147 NM_053589 B Rattus norvegicus GTPase GTPase Rab14 Rab14 (Rab14), mRNA. Length = 774 783 859 NM_012859 F Rattus norvegicus Hormone - Hormone - sensitive lipase, testicular sensitive lipase, testicular isoform isoform (Lipe), mRNA. Length = 3704 4589 343 AF062389 GENERAL, D kidney-specific protein (KS) Rattus norvegicus kidney-specific protein (KS) mRNA, complete cds 15137 1050 NM_031051 L Rattus norvegicus macrophage migration inhibitory factor macrophage migration inhibitory factor (Mif), mRNA. Length = 551 15138 1050 NM_031051 C Rattus norvegicus macrophage migration inhibitory factor macrophage migration inhibitory factor (Mif), mRNA. Length = 551 1430 816 M84648 GENERAL Dopa decarboxylase Dopa decarboxylase (aromatic L-amino (aromatic L-amino acid acid decarboxylase) decarboxylase) 1431 824 NM_012545 D Rattus norvegicus Dopa Dopa decarboxylase (aromatic L-amino decarboxylase (aromatic L- acid decarboxylase) amino acid decarboxylase) (Ddc), mRNA. Length = 1954 7892 661 AI229172 K ESTs, Weakly similar to FIBA_RAT Fibrinogen alpha/alpha-E chain precursor [ R. norvegicus ] 24264 876 NM_012999 GENERAL Rattus norvegicus Subtilisin - Subtilisin - like endoprotease like endoprotease (Pace4), mRNA. Length = 4153 21025 88 AA859241 GENERAL, synaptojanin 2 binding synaptojanin 2 binding protein A, C protein 21024 1021 NM_022599 GENERAL Rattus norvegicus synaptojanin 2 binding protein synaptojanin 2 binding protein (Synj2bp), mRNA. Length = 5215 15876 169 AA892582 G ESTs, Highly similar to RL8_HUMAN 60S ribosomal protein L8 [ R. norvegicus ] 343 844 NM_012747 L Rattus norvegicus Signal Signal transducer and activator of transducer and activator of transcription 3 transcription 3 (Stat3), mRNA. Length = 2924 15110 1043 NM_030827 GENERAL, I Rattus norvegicus glycoprotein 330 glycoprotein 330 (Lrp2), mRNA. Length = 15,438 15111 1043 NM_030827 GENERAL, I Rattus norvegicus glycoprotein 330 glycoprotein 330 (Lrp2), mRNA. Length = 15,438 15112 1043 NM_030827 I Rattus norvegicus glycoprotein 330 glycoprotein 330 (Lrp2), mRNA. Length = 15,438 3822 211 AA900863 GENERAL, H ESTs, Weakly similar to HE47_RAT Probable ATP-dependent RNA helicase p47 [ R. norvegicus ] 3823 706 AI233147 GENERAL ESTs, Weakly similar to HE47_RAT Probable ATP-dependent RNA helicase p47 [ R. norvegicus ] 20925 1019 NM_022594 L Rattus norvegicus enoyl Peroxisomal enoyl hydratase-like protein hydratase-like protein, peroxisomal (Ech1), mRNA. Length = 1097 15489 1060 NM_031137 F Rattus norvegicus tripeptidylpeptidase II tripeptidylpeptidase II (Tpp2), mRNA. Length = 4566 14983 637 AI179150 D Rattus norvegicus CDK110 mRNA 574 985 NM_019905 GENERAL, Rattus norvegicus calpactin I calpactin I heavy chain, hydroxyacid E, G, K heavy chain (Anxa2), mRNA. oxidase 3 (medium-chain), unknown Glu- Length = 1395 Pro dipeptide repeat protein 1570 1164 NM_053857 A Rattus norvegicus eukaryotic eukaryotic translation initiation factor 4E translation initiation factor 4E binding protein 1 binding protein 1 (Eif4ebp1), mRNA. Length = 843 14929 1134 NM_053330 GENERAL, Rattus norvegicus ribosomal ribosomal protein L21 G, K protein L21 (Rpl21), mRNA. Length = 554 4392 918 NM_017101 H Rattus norvegicus Peptidylprolyl isomerase A (cyclophilin A) Peptidylprolyl isomerase A (cyclophilin A) (Ppia), mRNA. Length = 743 1844 835 NM_012637 J Rattus norvegicus protein ESTs, protein tyrosine phosphatase, non- tyrosine phosphatase, non- receptor type 1 receptor type 1 (Ptpn1), mRNA. Length = 4127 1501 489 AI072634 GENERAL, Rattus norvegicus cytokeratin-18 mRNA, C, G, K partial cds 15190 503 AI102562 GENERAL Metallothionein 1 A Metallothionein 15189 803 M11794 B Metallothionein 1 A Metallothionein 1581 955 NM_017365 GENERAL, Rattus norvegicus PDZ and PDZ and LIM domain 1 (elfin) A, C LIM domain 1 (elfin) (Pdlim1), mRNA. Length = 1392 1687 645 AI179971 J Hemoglobin, alpha 1 Hemoglobin, alpha 1 1684 885 NM_013096 J Rattus norvegicus Hemoglobin, alpha 1 Hemoglobin, alpha 1 (Hba1), mRNA. Length = 556 1685 885 NM_013096 J Rattus norvegicus Hemoglobin, alpha 1 Hemoglobin, alpha 1 (Hba1), mRNA. Length = 556 1688 885 NM_013096 J Rattus norvegicus Hemoglobin, alpha 1 Hemoglobin, alpha 1 (Hba1), mRNA. Length = 556 1689 885 NM_013096 J Rattus norvegicus Hemoglobin, alpha 1 Hemoglobin, alpha 1 (Hba1), mRNA. Length = 556 25468 1123 NM_033234 J Rattus norvegicus Hemoglobin, beta Hemoglobin, beta (Hbb), mRNA. Length = 620 17829 1123 NM_033234 J Rattus norvegicus Hemoglobin, beta Hemoglobin, beta (Hbb), mRNA. Length = 620 17832 1123 NM_033234 J Rattus norvegicus Hemoglobin, beta Hemoglobin, beta (Hbb), mRNA. Length = 620 17833 1123 NM_033234 F Rattus norvegicus Hemoglobin, beta Hemoglobin, beta (Hbb), mRNA. Length = 620 9504 549 AI136723 F ESTs, Weakly similar to ZF37_RAT Zinc finger protein 37 (Zfp-37) [ R. norvegicus ] 15437 930 NM_017187 E Rattus norvegicus high high mobility group box 2 mobility group box 2 (Hmgb2), mRNA. Length = 1072 22412 1005 NM_022392 C, H Rattus norvegicus growth growth response protein (CL-6) response protein (CL-6) (LOC64194), mRNA. Length = 2410 22413 1005 NM_022392 C, H Rattus norvegicus growth growth response protein (CL-6) response protein (CL-6) (LOC64194), mRNA. Length = 2410 22414 1005 NM_022392 H Rattus norvegicus growth growth response protein (CL-6) response protein (CL-6) (LOC64194), mRNA. Length = 2410 22415 1005 NM_022392 C Rattus norvegicus growth growth response protein (CL-6) response protein (CL-6) (LOC64194), mRNA. Length = 2410 11434 778 D14014 B Cyclin D1 Cyclin D1 24232 1252 X75207 B Cyclin D1 Cyclin D1 19112 764 AI639157 J ribosomal protein L13 ribosomal protein L13 23854 1054 NM_031101 G Rattus norvegicus ribosomal ribosomal protein L13 protein L13 (Rpl13), mRNA. Length = 722 165 561 AI145329 F malate dehydrogenase malate dehydrogenase mitochondrial mitochondrial 1858 1064 NM_031315 B, L Rattus norvegicus acyl-CoA acyl-CoA thioesterase 1, cytosolic, thioesterase 1, cytosolic mitochondrial acyl-CoA thioesterase 1 (Cte1), mRNA. Length = 1591 1478 843 NM_012744 GENERAL Rattus norvegicus Pyruvate Pyruvate carboxylase carboxylase (Pc), mRNA. Length = 3945 1479 843 NM_012744 D Rattus norvegicus Pyruvate Pyruvate carboxylase carboxylase (Pc), mRNA. Length = 3945 4441 1249 X62146 G ESTs, Highly similar to RL11_HUMAN 60S ribosomal protein L11 [ R. norvegicus ] 18612 658 AI228624 G ribosomal protein L29 ribosomal protein L29 18642 500 AI102023 C Rattus norvegicus mRNA for ribosomal protein L35 19040 1058 NM_031114 GENERAL, Rattus norvegicus S-100 S-100 related protein, clone 42C C, G, K related protein, clone 42C (S100A10), mRNA. Length = 573 13647 155 AA892367 G ESTs, Highly similar to RL3_RAT 60S RIBOSOMAL PROTEIN L3 (L4) [ R. norvegicus ] 13646 1250 X62166 GENERAL, ESTs, Highly similar to RL3_RAT 60S A, G RIBOSOMAL PROTEIN L3 (L4) [ R. norvegicus ] 2232 303 AA963990 D ESTs, Weakly similar to S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ] 17661 1025 NM_022674 E Rattus norvegicus H2A H2A histone family, member Z histone family, member Z (H2afz), mRNA. Length = 811 18269 129 AA891769 GENERAL, ESTs, Weakly similar to SC65 D, L synaptonemal complex protein [ Rattus norvegicus ] [ R. norvegicus ] 3125 682 AI231028 K erythrocyte protein band 4.1- erythrocyte protein band 4.1-like 1 like 1 1490 1226 U63839 E nucleoporin p58 nucleoporin p58 17378 1061 NM_031138 D Rattus norvegicus ubiquitin ubiquitin conjugating enzyme conjugating enzyme (LOC81816), mRNA. Length = 1737 2010 1206 U05675 K Rattus norvegicus Sprague-Dawley fibrinogen B beta chain mRNA, complete cds 23445 849 NM_012792 GENERAL Rattus norvegicus Flavin- Flavin-containing monooxygenase 1 containing monooxygenase 1 (Fmo1), mRNA. Length = 2042 9191 485 AI072107 A ESTs, Weakly similar to 2008147B protein RAKc [ Rattus norvegicus ] [ R. norvegicus ] 3512 927 NM_017177 F Rattus norvegicus choline kinase-like choline/ethanolamine kinase (Chetk), mRNA. Length = 1679 23195 223 AA925026 GENERAL ESTs, Weakly similar to MCT7_RAT Mast cell protease 7 precursor (RMCP-7) (Tryptase, skin) [ R. norvegicus ] 12587 668 AI229979 GENERAL ESTs, Weakly similar to MOT2_RAT Monocarboxylate transporter 2 (MCT 2) [ R. norvegicus ] 725 1225 U62316 B solute carrier family 16 solute carrier family 16 (monocarboxylic (monocarboxylic acid acid transporters), member 7 transporters), member 7 1558 1217 U28504 H solute carrier family 17 solute carrier family 17 vesicular vesicular glutamate glutamate transporter), member 1 transporter), member 1 2109 1010 NM_022511 G Rattus norvegicus profilin profilin (Pfn1), mRNA. Length = 689 20449 1074 NM_031530 GENERAL Rattus norvegicus Small Small inducible gene JE inducible gene JE (Scya2), mRNA. Length = 780 954 1121 NM_032061 B Rattus norvegicus contactin contactin associated protein 1 associated protein 1 (Cntnap1), mRNA. Length = 5350 15273 1063 NM_031237 E Rattus norvegicus ubiquitin- ubiquitin-conjugating enzyme E2D 3 conjugating enzyme E2D 3 (homologous to yeast UBC4/5) (homologous to yeast UBC4/5) (Ube2d3), mRNA. Length = 1531 15277 1063 NM_031237 D Rattus norvegicus ubiquitin- ubiquitin-conjugating enzyme E2D 3 conjugating enzyme E2D 3 (homologous to yeast UBC4/5) (homologous to yeast UBC4/5) (Ube2d3), mRNA. Length = 1531 25290 1174 NM_057100 J Rattus norvegicus growth growth arrest specific 6 arrest specific 6 (Gas6), mRNA. Length = 2573 2632 965 NM_019213 A, D Rattus norvegicus jumping jumping translocation breakpoint translocation breakpoint (Jtb), mRNA. Length = 897 23307 1176 NM_057119 D Rattus norvegicus splicing splicing factor, arginine/serine-rich factor, arginine/serine-rich (transformer 2 Drosophila homolog) 10 (transformer 2 Drosophila homolog) 10 (Sfrs10), mRNA. Length = 1978 16006 344 AF062594 GENERAL nucleosome assembly nucleosome assembly protein 1-like 1 protein 1-like 1 16007 344 AF062594 E nucleosome assembly nucleosome assembly protein 1-like 1 protein 1-like 1 7665 429 AI030668 E nucleosome assembly nucleosome assembly protein 1-like 1 protein 1-like 1 1312 1130 NM_053291 J Rattus norvegicus ESTs, Highly similar to A33792 phosphoglycerate kinase 1 phosphoglycerate kinase (EC 2.7.2.3) - (Pgk1), mRNA. Length = 1675 rat [ R. norvegicus ], phosphoglycerate kinase 1 21400 811 M36410 C, F sepiapterin reductase sepiapterin reductase 10464 793 J05510 GENERAL, I Inositol 1,4,5-triphosphate Inositol 1,4,5-triphosphate receptor type 1 receptor type 1 20848 954 NM_017343 GENERAL, Rattus norvegicus myosin Rat mRNA for myosin regulatory light G, K regulatory light chain chain (RLC) (MRLCB), mRNA. Length = 1139 20849 954 NM_017343 GENERAL, Rattus norvegicus myosin Rat mRNA for myosin regulatory light G, K regulatory light chain chain (RLC) (MRLCB), mRNA. Length = 1139 6290 571 AI169232 C kinase D-interacting kinase D-interacting substance of 220 kDa substance of 220 kDa 20682 1028 NM_022952 B Rattus norvegicus clathrin- clathrin-associated protein 17 associated protein 17 (Ap2s1), mRNA. Length = 797 20753 1104 NM_031763 GENERAL, Rattus norvegicus platelet- platelet-activating factor acetylhydrolase C, I activating factor beta subunit (PAF-AH beta) acetylhydrolase beta subunit (PAF-AH beta) (Pafah1b1), mRNA. Length = 1233 17570 626 AI177683 C, E Rattus norvegicus mRNA for hnRNP protein, partial 19110 872 NM_012963 A, J Rattus norvegicus High High mobility group 1 mobility group 1 (Hmg1), mRNA. Length = 1225 19433 57 AA819776 H ESTs, Weakly similar to HS9B_RAT Heat shock protein HSP 90-beta (HSP 84) [ R. norvegicus ] 20795 253 AA944397 H HMm: heat shock protein, 86 kDa 1 ESTs, Moderately similar to HS9B_RAT Heat shock protein HSP 90-beta (HSP 84) [ R. norvegicus ] 16518 612 AI176546 C, K HMm: heat shock protein, 86 kDa 1 ESTs, Moderately similar to HS9B_RAT Heat shock protein HSP 90-beta (HSP 84 [ R. norvegicus ] 11840 1258 Y15068 H, I stress-induced- stress-induced-phosphoprotein 1 phosphoprotein 1 (Hsp70/Hsp90-organizing protein) (Hsp70/Hsp90-organizing protein) 9067 460 AI070087 GENERAL ESTs, Weakly similar to NUCL_RAT Nucleolin (Protein C23) [ R. norvegicus ] 3016 37 AA818069 H polyubiquitin polyubiquitin 3015 779 D16554 A polyubiquitin polyubiquitin 825 270 AA946108 GENERAL, A Rattus norvegicus laminin-5 alpha 3 chain mRNA, complete cds 18070 898 NM_013160 GENERAL Rattus norvegicus Max Max interacting protein 1 interacting protein 1 (Mxi1), mRNA. Length = 922 3467 756 AI237835 GENERAL, I ESTs, Moderately similar to MXI1_RAT MAX interacting protein 1 (MXI1 protein) [ R. norvegicus ] 3465 898 NM_013160 GENERAL, Rattus norvegicus Max ESTs, Moderately similar to MXI1_RAT B, F interacting protein 1 (Mxi1), MAX interacting protein 1 (MXI1 protein) mRNA. Length = 922 [ R. norvegicus ] 1970 900 NM_013194 K Rattus norvegicus Myosin, Myosin, heavy polypeptide 9, non-muscle heavy polypeptide 9, non- muscle (Myh9), mRNA. Length = 6060 1141 1007 NM_022401 GENERAL, Rattus norvegicus plectin plectin C, G (Plec1), mRNA. Length = 15,231 4445 602 AI175466 G ESTs, Weakly similar to RASH_RAT TRANSFORMING PROTEIN P21/H-RAS- 1 (C-H-RAS) [ R. norvegicus ] 18741 107 AA874859 GENERAL ESTs, Weakly similar to S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ] 12016 158 AA892404 C ESTs, Weakly similar to S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ] 5601 700 AI232461 GENERAL, I flavin containing ESTs, Weakly similar to S33758 flavin- monooxygenase 4 containing monooxygenase 1 —rat [ R. norvegicus ] 15535 946 NM_017283 L Rattus norvegicus proteasome (prosome, macropain) proteasome (prosome, subunit, alpha type 6 macropain) subunit, alpha type 6 (Psma6), mRNA. Length = 932 15538 946 NM_017283 L Rattus norvegicus proteasome (prosome, macropain) proteasome (prosome, subunit, alpha type 6 macropain) subunit, alpha type 6 (Psma6), mRNA. Length = 932 17345 144 AA892014 E HLA-B associated transcript HLA-B associated transcript 1A 1A 18678 685 AI231295 L ESTs, Weakly similar to SM4F_RAT Semaphorin 4F precursor (Semaphorin W) (Sema W) [ R. norvegicus ] 17771 42 AA818224 GENERAL Rat mRNA for beta-tubulin T beta15 18361 12 AA799591 GENERAL ESTs, Highly similar to TBB1_RAT TUBULIN BETA CHAIN (T BETA-15) [ R. norvegicus ] 8215 588 AI171692 D ferritin light chain 1 ESTs, Highly similar to S66270 kynurenine—oxoglutarate transaminase (EC 2.6.1.7)/glutamine - phenylpyruvate transaminase (EC 2.6.1.64) mitochondrial precursor [validated] - rat [ R. norvegicus ], ferritin light chain 1 8211 1008 NM_022500 H Rattus norvegicus ferritin ferritin light chain 1 light chain 1 (Ftl1), mRNA. Length = 552 8212 1008 NM_022500 L Rattus norvegicus ferritin ferritin light chain 1 light chain 1 (Ftl1), mRNA. Length = 552 8210 1195 S61960 GENERAL ferritin light chain 1 ferritin light chain 1 1410 1126 NM_052798 H Rattus norvegicus Kidney 1 zinc finger protein 354A (Kid1), mRNA. Length = 2563 8640 1184 NM_057211 D Rattus norvegicus Kruppel- Kruppel-like factor 9 like factor 9 (Klf9), mRNA. Length = 2721 9541 1015 NM_022542 L Rattus norvegicus rhoB gene rhoB gene (Arhb), mRNA. Length = 2183 20126 826 NM_012591 K Rattus norvegicus Interferon Interferon regulatory factor 1, sirtuin 2 regulatory factor 1 (Irf1), (silent mating type information regulation mRNA. Length = 2078 2, homolog) 2 ( S. cerevisiae ) 15069 1111 NM_031840 H Rattus norvegicus Farnesyl diphosphate synthase Farnesyldiphosphate synthase (Fdps), mRNA. Length = 1271 23778 209 AA899854 E topoisomerase (DNA) II topoisomerase (DNA) II alpha alpha 23780 1001 NM_022183 E Rattus norvegicus topoisomerase (DNA) II alpha topoisomerase (DNA) II alpha (Top2a), mRNA. Length = 6052 16718 538 AI111537 H Rat mRNA for RT1.D beta chain, Rattus norvegicus Class II MHC RT1.D(u) beta chain precursor (RT1.D(u)) mRNA, complete cds 19678 992 NM_021653 GENERAL Rattus norvegicus Thyroxine Thyroxine deiodinase, type I deiodinase, type I (Dio1), mRNA. Length = 2106 19679 992 NM_021653 GENERAL, Rattus norvegicus Thyroxine Thyroxine deiodinase, type I A, D, G, I deiodinase, type I (Dio1), mRNA. Length = 2106 1943 912 NM_017061 L Rattus norvegicus Lysyl Lysyl oxidase oxidase (Lox), mRNA. Length = 4557 1946 912 NM_017061 F Rattus norvegicus Lysyl Lysyl oxidase oxidase (Lox), mRNA. Length = 4557 22386 27 AA800844 F ESTs, Moderately similar to LYOX_RAT Protein-lysine 6-oxidase precursor (Lysyl oxidase) [ R. norvegicus ] 8829 845 NM_012749 GENERAL, Rattus norvegicus Nucleolin Nucleolin A, F, K (Ncl), mRNA. Length = 2142 17477 1181 NM_057194 GENERAL, Rattus norvegicus phospholipid scramblase 1 K, L phospholipid scramblase 1 (Plscr1), mRNA. Length = 1569 6321 496 AI101256 GENERAL ESTs, Weakly similar to S09017 heterogeneous ribonuclear particle protein type C - rat (fragment) [ R. norvegicus ] 1453 1165 NM_053887 F, K Rattus norvegicus mitogen mitogen activated protein kinase kinase activated protein kinase kinase 1 kinase kinase 1 (Map3k1), mRNA. Length = 5180 1454 1165 NM_053887 GENERAL, K Rattus norvegicus mitogen mitogen activated protein kinase kinase activated protein kinase kinase 1 kinase kinase 1 (Map3k1), mRNA. Length = 5180 13723 871 NM_012935 K Rattus norvegicus Crystallin, Crystallin, alpha polypeptide 2, ESTs, alpha polypeptide 2 (Cryab), ESTs, Weakly similar to T46637 mRNA. Length = 528 transcription factor 1, neural —rat [ R. norvegicus ] 22596 277 AA955298 GENERAL ESTs, Weakly similar to T46637 transcription factor 1, neural - rat [ R. norvegicus ] 16354 782 D50564 C mercaptopyruvate mercaptopyruvate sulfurtransferase sulfurtransferase 21165 1047 NM_031005 K Rattus norvegicus non- actinin, alpha 1 muscle alpha-actinin 1 (Actn1), mRNA. Length = 2956 21166 1047 NM_031005 K Rattus norvegicus non- actinin, alpha 1 muscle alpha-actinin 1 (Actn1), mRNA. Length = 2956 20983 440 AI044900 K fatty acid Coenzyme A fatty acid Coenzyme A ligase, long chain 2 ligase, long chain 2 15904 414 AI013971 F neurofascin neurofascin 1993 1089 NM_031655 GENERAL, Rattus norvegicus latexin latexin E, G, K (Lxn), mRNA. Length = 1087 20780 1017 NM_022590 GENERAL, D Rattus norvegicus low affinity low affinity Na-dependent glucose Na-dependent glucose transporter (SGLT2) transporter (SGLT2) (Sglt2), mRNA. Length = 2254 6641 1012 NM_022533 GENERAL, Rattus norvegicus plasmolipin A, I plasmolipin (Z49858), mRNA. Length = 1475 5711 442 AI045151 GENERAL ESTs, Weakly similar to solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 [ Rattus norvegicus] [ R. norvegicus ] 19768 1119 NM_031986 GENERAL, Rattus norvegicus syntenin syntenin C, G (Sdcbp), mRNA. Length = 2077 24649 903 NM_016988 C, K Rattus norvegicus Acid Acid phosphatase 2, lysozymal phosphatase 2, lysozymal (Acp2), mRNA. Length = 2009 1698 906 NM_017000 GENERAL, Rattus norvegicus Diaphorase (NADH/NADPH) B, H, I Diaphorase (NADH/NADPH) (Dia4), mRNA. Length = 1396 24431 868 NM_012912 GENERAL, F Rattus norvegicus Activating Activating transcription factor 3 transcription factor 3 (Atf3), mRNA. Length = 1893 3438 182 AA892921 K ESTs, Weakly similar to A55143 calpain (EC 3.4.22.17) light chain - rat (fragment) [ R. norvegicus ] 24496 837 NM_012654 GENERAL, Rattus norvegicus Solute Solute carrier family 9 (sodium/hydrogen I, K carrier family 9 exchanger 3), antiporter 3, Na+/H+ (sodium/hydrogen exchanger (amiloride insensitive) 3), antiporter 3, Na+/H+ (amiloride insensitive) (Slc9a3), mRNA. Length = 5153 16350 777 AJ011811 G claudin 7 claudin 7 16351 777 AJ011811 G claudin 7 claudin 7 21914 1257 Y13336 J defender against cell death 1 defender against cell death 1 7784 848 NM_012789 GENERAL, I Rattus norvegicus Dipeptidyl Dipeptidyl peptidase 4 peptidase 4 (Dpp4), mRNA. Length = 4835 21145 339 AF038571 GENERAL, B Solute carrier family 1 A1 Solute carrier family 1 A1 (brain (brain glutamate transporter) glutamate transporter) 21147 784 D63772 GENERAL, Solute carrier family 1 A1 Solute carrier family 1 A1 (brain F, H, I, J, L (brain glutamate transporter) glutamate transporter) 23961 929 NM_017181 GENERAL, Rattus norvegicus fumarylacetoacetate hydrolase E, G, I fumarylacetoacetate hydrolase (Fah), mRNA. Length = 1386 18990 1072 NM_031509 H Rattus norvegicus Glutathione-S-transferase, alpha type Glutathione-S-transferase, (Yc?) alpha type (Ya) (Gsta1), mRNA. Length = 1178 20817 398 AI012589 GENERAL glutathione S-transferase, pi 2 glutathione S-transferase, pi 2 20818 1233 X02904 GENERAL glutathione S-transferase, pi 2 glutathione S-transferase, pi 2 6630 594 AI172184 F ESTs, Weakly similar to SYPH_RAT SYNAPTOPHYSIN (MAJOR SYNAPTIC VESICLE PROTEIN P38) [ R. norvegicus ] 17908 967 NM_019242 GENERAL Rattus norvegicus interferon- interferon-related developmental related developmental regulator 1 regulator 1 (Ifrd1), mRNA. Length = 1736 17850 508 AI102750 H ESTs, Weakly similar to JQ0866 T- complex protein 1 - rat [ R. norvegicus ] 187 866 NM_012903 F Rattus norvegicus Acid Acid nuclear phosphoprotein 32 (leucine nuclear phosphoprotein 32 rich) (leucine rich) (Anp32), mRNA. Length = 1017 24762 1139 NM_053442 GENERAL, D Rattus norvegicus solute solute carrier family 7 (cationic amino carrier family 8 (cationic acid transporter, y+ system), member 8 amino acid transporter, y+ system), member 7 (Lat4), mRNA. Length = 4117 22434 874 NM_012974 F Rattus norvegicus Laminin Laminin chain beta 2 chain beta 2 (Lamb2), mRNA. Length = 5581 16147 1220 U51898 GENERAL phospholipase A2, group VI phospholipase A2, group VI 13609 161 AA892468 GENERAL, protease, serine, 8 protease, serine, 8 (prostasin) H, I (prostasin) 13610 161 AA892468 GENERAL, protease, serine, 8 protease, serine, 8 (prostasin) A, C, F, H, I, K (prostasin) 13611 639 AI179378 GENERAL, protease, serine, 8 protease, seine, 8 (prostasin) F, H (prostasin) 7299 413 AI013911 GENERAL, ESTs, Weakly similar to cold inducible A, B, L RNA-binding protein [ Rattus norvegicus ] [ R. norvegicus ] 23806 842 NM_012733 D Rattus norvegicus Retinol- Retinol-binding protein 1 binding protein 1 (Rbp1), mRNA. Length = 601 20886 886 NM_013097 E, G Rattus norvegicus Deoxyribonuclease I Deoxyribonuclease I (Dnase1), mRNA. Length = 1143 20887 886 NM_013097 E, G Rattus norvegicus Deoxyribonuclease I Deoxyribonuclease I (Dnase1), mRNA. Length = 1143 13392 922 NM_017148 GENERAL Rattus norvegicus cysteine cysteine rich protein 1 rich protein 1 (Csrp1), mRNA. Length = 1403 17325 22 AA800587 GENERAL, ESTs, Weakly similar to GSHC_RAT G, K Glutathione peroxidase (GSHPX-1) (Cellular glutathione peroxidase) [ R. norvegicus ] 6675 36 AA817994 C ESTs, Weakly similar to regulator of G- protein signaling 3 [ Rattus norvegicus ] [ R. norvegicus ] 1510 937 NM_017224 GENERAL, Rattus norvegicus organic solute carrier family 22 (organic anion D, K cationic transporter-like 1 transporter), member 6 (Orctl1), mRNA. Length = 2227 15986 1256 Y09945 GENERAL, I putative integral membrane putative integral membrane transport transport UST1r UST1r 23076 752 AI237388 K ESTs, Weakly similar to IFR1_RAT INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 (NERVE GROWTH FACTOR- INDUCIBLE PROTEIN PC4) (IRPR) [ R. norvegicus ] 17363 227 AA925150 F, K ESTs, Moderately similar to 2118320A neurodegeneration-associated protein 1 [ Rattus norvegicus ] [ R. norvegicus ] 23261 226 AA925145 GENERAL, I ESTs, Weakly similar to betaine- homocysteine methyltransferase [ Rattus norvegicus ] [ R. norvegicus ] 11653 62 AA848689 A, F HMm:carbonic anhydrase 5b, ESTs, Weakly similar to CAH5_RAT mitochondrial Carbonic anhydrase VA, mitochondrial precursor (Carbonate dehydratase VA) (CA-VA) [ R. norvegicus ] 1962 995 NM_021750 J Rattus norvegicus cysteine- CCA2 protein sulfinate decarboxylase (Csad), mRNA. Length = 2413 4312 333 AB010635 J carboxylesterase 2 (intestine, carboxylesterase 2 (intestine, liver) liver) 15132 684 AI231180 G ESTs, Moderately similar to JC4588 RNA- binding protein PIPPin - rat [ R. norvegicus ] 770 1080 NM_031584 GENERAL Rattus norvegicus solute solute carrier family 22, member 2 carrier family 22, member 2 (Slc22a2), mRNA. Length = 2152 11162 354 AI008183 C ESTs, Weakly similar to solute carrier family 29 (nucleoside transporters), member 1 [ Rattus norvegicus ] [ R. norvegicus ] 20741 347 AF084186 A, J alpha-fodrin alpha-fodrin 19822 643 AI179599 A Ras-related GTP-binding Ras-related GTP-binding protein Rab29 protein Rab29 18300 878 NM_013030 GENERAL, Rattus norvegicus Solute Rattus norvegicus mRNA for NaPi-2 H, I, L carrier family 17 alpha, complete cds (sodium/hydrogen exchanger), member 2 (Slc34a1), mRNA. Length = 2440 23321 176 AA892821 GENERAL aldo-keto reductase family 7, aldo-keto reductase family 7, member A2 member A2 (aflatoxin (aflatoxin aldehyde reductase) aldehyde reductase) 20864 901 NM_013215 B, J Rattus norvegicus aflatoxin aflatoxin B1 aldehyde reductase B1 aldehyde reductase (AFAR), mRNA. Length = 1272 14763 256 AA944481 L ESTs, Weakly similar to FCN2_RAT Ficolin 2 precursor (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin B) (Serum lectin P35) (EBP-37) (Hucolin) [ R. norvegicus ] 16082 109 AA874887 E ESTs, Weakly similar to segregation of mitotic chromosomes b; SMC (segregation of mitotic chromosomes 1)- like 1 (yeast) [ Rattus norvegicus ] [ R. norvegicus ] 1439 1224 U57391 H SH2-B PH domain containing SH2-B PH domain containing signaling signaling mediator 1 mediator 1 23538 506 AI102727 GENERAL solute carrier family 20 solute carrier family 20 (phosphate (phosphate transporter), transporter), member 1 member 1 24770 919 NM_017111 GENERAL, Rattus norvegicus solute solute carrier family (organic anion G, I, J carrier family (organic anion transporter) member 1 transporter) member 1 (Slc21a1), mRNA. Length = 2758 20873 616 AI177042 G ESTs, Highly similar to R3RT19 ribosomal protein S19, cytosolic [validated] - rat [ R. norvegicus ] 2250 1024 NM_022643 GENERAL Rattus norvegicus Testis- ESTs, Highly similar to 0506206A histone specific histone 2b (Th2b), H2B [ Rattus norvegicus ] [ R. norvegicus ] mRNA. Length = 470 17682 157 AA892382 GENERAL, I camello-like 1 camello-like 1 12355 213 AA923857 D ESTs, Highly similar to 1809184A pregnancy-specific glycoprotein [ Rattus norvegicus ] [ R. norvegicus ] 15039 1090 NM_031672 GENERAL, Rattus norvegicus solute solute carrier family 15 (H+/peptide F, I carrier family 15 (H+/peptide transporter), member 2 transporter), member 2 (Slc15a2), mRNA. Length = 3923 20816 990 NM_021261 GENERAL, Rattus norvegicus thymosin, thymosin, beta 10 G, K beta 10 (Tmsb10), mRNA. Length = 539 17196 956 NM_019123 GENERAL, I Rattus norvegicus sialyltransferase 7 ((alpha-N- sialyltransferase 7 ((alpha-N- acetylneuraminyl 2,3-betagalactosyl-1,3)- acetylneuraminyl 2,3- N-acetyl galactosaminide alpha-2,6- betagalactosyl-1,3)-N-acetyl sialyltransferase) C galactosaminide alpha-2,6- sialyltransferase) C (Siat7c), mRNA. Length = 2956 21975 923 NM_017154 B, L Rattus norvegicus xanthine xanthine dehydrogenase dehydrogenase (Xdh), mRNA. Length = 4198 573 692 AI232087 J hydroxyacid oxidase 3 hydroxyacid oxidase 3 (medium-chain) (medium-chain) 18074 1100 NM_031738 K Rattus norvegicus solute solute carrier family 29 (nucleoside carrier family 29 (nucleoside transporters), member 2 transporters), member 2 (Slc29a2), mRNA. Length = 1678 19943 770 AI639479 GENERAL, ESTs, Highly similar to 2008147A protein F, G RAKb [ Rattus norvegicus ] [ R. norvegicus ] 17284 789 J02827 G Branched chain alpha- Branched chain alpha-ketoacid ketoacid dehydrogenase dehydrogenase subunit E1 alpha subunit E1 alpha 22820 58 AA848315 GENERAL ESTs, Weakly similar to guanosine monophosphate reductase [ Rattus norvegicus ] [ R. norvegicus ] 21012 788 J02592 B Glutathione-S-transferase, Glutathione-S-transferase, mu type 2 mu type 2 (Yb2) (Yb2) 21014 791 J03914 B, L Glutathione-S-transferase, Glutathione-S-transferase, mu type 2 mu type 2 (Yb2) (Yb2) 21443 968 NM_019262 GENERAL, L Rattus norvegicus complement component 1, q complement component 1, q subcomponent, beta polypeptide subcomponent, beta polypeptide (C1qb), mRNA. Length = 1136 13310 618 AI177119 L ESTs, Weakly similar to S49158 complement protein C1q beta chain precursor - rat [ R. norvegicus ] 6691 248 AA943028 J ESTs, Highly similar to KFMS_RAT Macrophage colony stimulating factor I receptor precursor (CSF-1-R) (Fms proto- oncogene) (c-fms) [ R. norvegicus ] 13104 374 AI010224 D Adducin 3, gamma Adducin 3, gamma 20086 403 AI013260 GENERAL, H lamin A lamin A 15291 537 AI111401 D multiple inositol multiple inositol polyphosphate histidine polyphosphate histidine phosphatase 1 phosphatase 1 13618 678 AI230724 GENERAL, I SAC1 (supressor of actin SAC1 (supressor of actin mutations 1, mutations 1, homolog)-like homolog)-like ( S. cerevisiae ) ( S. cerevisiae ) 24321 698 AI232340 GENERAL, Stromal cell-derived factor 1 Stromal cell-derived factor 1 K, L 25233 774 AJ000556 E Janus kinase 1 15017 790 J03752 B microsomal glutathione S- microsomal glutathione S-transferase 1 transferase 1 20414 799 L14323 GENERAL Phospholipase C-beta1 Phospholipase C-beta1 25377 800 L25387 D phosphofructokinase, platelet 21053 805 M15481 GENERAL Insulin-like growth factor I Insulin-like growth factor I 21882 815 M83740 GENERAL, D dimerization cofactor of hepatocyte nuclear factor-1- alpha 15540 832 NM_012620 K Rattus norvegicus serine (or serine (or cysteine) proteinase inhibitor, cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator clade E (nexin, plasminogen inhibitor type 1), member 1 activator inhibitor type 1), member 1 (Serpine1), mRNA. Length = 3053 503 841 NM_012704 C Rattus norvegicus Rat kidney Rat kidney prostaglandin EP3 receptor prostaglandin EP3 receptor (Ptger3), mRNA. Length = 1253 20828 846 NM_012752 GENERAL, Rattus norvegicus CD24 CD24 antigen E, K antigen (Cd24), mRNA. Length = 1703 20829 846 NM_012752 GENERAL, D Rattus norvegicus CD24 CD24 antigen antigen (Cd24), mRNA. Length = 1703 20830 846 NM_012752 GENERAL Rattus norvegicus CD24 CD24 antigen antigen (Cd24), mRNA. Length = 1703 24893 853 NM_012817 B Rattus norvegicus Insulin-like Insulin-like growth factor-binding protein 5 growth factor-binding protein 5 (Igfbps), mRNA. Length = 1630 11137 856 NM_012839 J Rattus norvegicus Cytochrome C, expressed in somatic Cytochrome C, expressed in tissues somatic tissues (Cycs), mRNA. Length = 318 23651 862 NM_012881 GENERAL, Rattus norvegicus Sialoprotein (osteopontin) G, K Sialoprotein (osteopontin) (Spp1), mRNA. Length = 1457 433 869 NM_012916 C Rattus norvegicus Brevican Brevican (Bcan), mRNA. Length = 2534 24843 880 NM_013042 J Rattus norvegicus Trefoil Trefoil factor (intestinal) factor (intestinal) (Tff3), mRNA. Length = 431 1542 932 NM_017193 J Rattus norvegicus kynurenine aminotransferase II kynurenine aminotransferase II (Kat2), mRNA. Length = 1828 13939 933 NM_017212 D Rattus norvegicus microtubule-associated protein tau microtubule-associated protein tau (Mapt), mRNA. Length = 5240 13940 933 NM_017212 D Rattus norvegicus microtubule-associated protein tau microtubule-associated protein tau (Mapt), mRNA. Length = 5240 12349 947 NM_017290 GENERAL Rattus norvegicus ATPase, ATPase, Ca++ transporting, cardiac Ca++ transporting, cardiac muscle, slow twitch 2 muscle, slow twitch 2 (Atp2a2), mRNA. Length = 5648 245 952 NM_017336 J Rattus norvegicus receptor- receptor-type protein tyrosine type protein tyrosine phosphatase D30 phosphatase D30 (Ptpro), mRNA. Length = 4871 247 952 NM_017336 J Rattus norvegicus receptor- receptor-type protein tyrosine type protein tyrosine phosphatase D30 phosphatase D30 (Ptpro), mRNA. Length = 4871 20298 981 NM_019374 I Rattus norvegicus prodynorphin prodynorphin (Pdyn), mRNA. Length = 747 20085 997 NM_021755 C Rattus norvegicus lamin lamin A (Lmn), mRNA. Length = 3091 23151 1000 NM_022005 B, L Rattus norvegicus FXYD FXYD domain-containing ion transport domain-containing ion regulator 6 transport regulator 6 (Fxyd6), mRNA. Length = 1711 4011 1076 NM_031543 J Rattus norvegicus Cytochrome P450, subfamily 2e1 Cytochrome P450, subfamily (ethanol-inducible) 2e1 (ethanol-inducible) (Cyp2e1), mRNA. Length = 1624 4012 1076 NM_031543 J Rattus norvegicus Cytochrome P450, subfamily 2e1 Cytochrome P450, subfamily (ethanol-inducible) 2e1 (ethanol-inducible) (Cyp2e1), mRNA. Length = 1624 17933 1122 NM_032615 K Rattus norvegicus membrane membrane interacting protein of RGS16 interacting protein of RGS16 (Mir16), mRNA. Length = 1203 16394 1140 NM_053485 K Rattus norvegicus calcium calcium binding protein A6 (calcyclin) binding protein A6 (calcyclin) (S100a6), mRNA. Length = 291 13004 1154 NM_053623 J, L Rattus norvegicus fatty acid- fatty acid-Coenzyme A ligase, long chain 4 Coenzyme A ligase, long chain 4 (Facl4), mRNA. Length = 4862 13005 1154 NM_053623 C Rattus norvegicus fatty acid- fatty acid-Coenzyme A ligase, long chain 4 Coenzyme A ligase, long chain 4 (Facl4), mRNA. Length = 4862 25686 1237 X51536 F ribosomal protein S3 25718 1248 X62145 GENERAL, G ribosomal protein L8 25098 2 AA108277 C, H 25106 4 AA686579 B 19222 5 AA799279 J ESTs, Highly similar to mitochondrial carrier homolog 2 [ Mus musculus ] [ M. musculus ] 18272 6 AA799294 I ESTs 18396 7 AA799330 GENERAL, ESTs, Weakly similar to T47122 cell H, I division protein pelota [imported] - fruit fly ( Drosophila melanogaster ) [ D. melanogaster ] 20961 8 AA799465 L EST 23063 10 AA799534 GENERAL, K ESTs 22669 11 AA799567 D ESTs 15844 13 AA799600 D ESTs, Highly similar to hypothetical protein DKFZp586I021 [ Homo sapiens ] [ H. sapiens ] 22910 14 AA799654 K ESTs 14309 15 AA799676 GENERAL ESTs 17494 16 AA799751 GENERAL, K ESTs 18360 17 AA799771 GENERAL, I ESTs 23202 18 AA799971 GENERAL ESTs, Moderately similar to hypothetical protein FLJ10986 [ Homo sapiens ] [ H. sapiens ] 23203 18 AA799971 GENERAL ESTs, Moderately similar to hypothetical protein FLJ10986 [ Homo sapiens ] [ H. sapiens ] 21029 19 AA799981 C ESTs 21086 21 AA800305 D ESTs, Moderately similar to RB5A_HUMAN Ras-related protein Rab- 5A [ H. sapiens ] 13930 23 AA800613 GENERAL EST 6595 24 AA800753 C ESTs 21388 25 AA800771 C ESTs 12797 26 AA800790 D ESTs 14600 28 AA801076 K ESTs 15027 30 AA801212 D ESTs 7543 31 AA801395 GENERAL ESTs 5930 32 AA817688 B ESTs 24237 33 AA817726 GENERAL ESTs 10983 39 AA818132 G ESTs 6014 40 AA818153 B, H ESTs 6022 41 AA818197 E ESTs 5923 43 AA818355 GENERAL, I ESTs 11610 44 AA818725 J ESTs 4291 45 AA818741 GENERAL, ESTs I, J 4330 46 AA818747 GENERAL, B ESTs 19723 47 AA818761 GENERAL ESTs 4952 49 AA818907 GENERAL, C ESTs 10985 50 AA818998 GENERAL, I ESTs 16958 51 AA819021 A EST 5863 52 AA819111 GENERAL, ESTs H, I 12684 53 AA819179 F ESTs 6336 55 AA819403 GENERAL ESTs 6278 56 AA819471 B ESTs 6614 59 AA848389 G ESTs, Weakly similar to Iron-containing alcohol dehydrogenases [ Caenorhabditis elegans ] [ C. elegans ] 21125 60 AA848437 GENERAL, L ESTs 23505 61 AA848496 J ESTs, Moderately similar to IF4B_HUMAN Eukaryotic translation initiation factor 4B (eIF-4B) [ H. sapiens ] 21140 63 AA848738 J ESTs, Weakly similar to phospholipase D3 [ Mus musculus ] [ M. musculus ] 2924 64 AA848948 H ESTs, Weakly similar to F18H3.1.p [ Caenorhabditis elegans ] [ C. elegans ] 22631 65 AA849030 K ESTs 17339 67 AA849497 GENERAL ESTs 18447 69 AA849939 F ESTs 12129 70 AA849966 A, D ESTs, Moderately similar to Mpv17 transgene, kidney disease mutant-like [ Mus musculus ] [ M. musculus ] 21341 71 AA850195 I ESTs 14410 72 AA850292 F ESTs 13615 73 AA850364 L ESTs, Moderately similar to RB17_MOUSE Ras-related protein Rab- 17 [ M. musculus ] 21766 74 AA850916 J ESTs 13349 78 AA851417 GENERAL, ESTs H, I 24377 80 AA858590 H ESTs 1801 81 AA858636 E ESTs, Highly similar to mini chromosome maintenance deficient 7 ( S. cerevisiae ) [ Mus musculus ] [ M. musculus ] 18350 82 AA858674 C ESTs 11615 83 AA858816 D ESTs, Weakly similar to F53A3.7.p [ Caenorhabditis elegans ] [ C. elegans ] 7279 84 AA858892 GENERAL ESTs 6431 86 AA859085 L ESTs 17361 87 AA859114 GENERAL, ESTs A, G 16314 89 AA859348 GENERAL, I ESTs 4178 90 AA859536 GENERAL, A ESTs 14353 91 AA859585 D ESTs 19067 92 AA859663 GENERAL, B ESTs 11079 95 AA859829 E ESTs 11481 96 AA859832 B ESTs 22562 97 AA859835 F ESTs 22927 98 AA859920 E ESTs 23000 99 AA859933 F ESTs 18468 101 AA859966 J ESTs, Moderately similar to TNP1_HUMAN Tumor necrosis factor, alpha-induced protein 1, endothelial (B12 protein) [ H. sapiens ] 19377 102 AA859971 A, E ESTs, Highly similar to RIKEN cDNA 0610010I12 [ Mus musculus ] [ M. musculus ] 19144 104 AA860049 A ESTs 9391 106 AA866477 J ESTs, Moderately similar to COXM_MOUSE Cytochrome c oxidase polypeptide VIIb, mitochondrial precursor [ M. musculus ] 16070 108 AA874873 D ESTs 16091 110 AA874897 J ESTs 16312 112 AA875032 GENERAL, ESTs I, L 15421 114 AA875286 C, L ESTs, Highly similar to prostate tumor over expressed gene 1 [ Homo sapiens ] [ H. sapiens ] 15446 115 AA875327 L ESTs 7936 116 AA875495 GENERAL, ESTs A, B, C, I 15574 118 AA875552 H ESTs 15618 119 AA875620 GENERAL ESTs 15833 122 AA891171 K ESTs, Moderately similar to N4BM_HUMAN NADH-ubiquinone oxidoreductase subunit B14.5b (Complex I-B14.5b) (CI-B14.5b) [ H. sapiens ] 16446 123 AA891423 L ESTs 474 124 AA891670 D ESTs, Moderately similar to mannosidase 2, alpha B1; lysosomal alpha-mannosidase [ Mus musculus ] [ M. musculus ] 17420 125 AA891693 GENERAL ESTs 11959 126 AA891735 D ESTs 17693 127 AA891737 J ESTs 17256 128 AA891739 GENERAL, ESTs, Weakly similar to F52H3.5.p C, E, I [ Caenorhabditis elegans ] [ C. elegans ] 9905 130 AA891774 GENERAL, ESTs A, I, K 17289 131 AA891785 E ESTs, Weakly similar to A54756 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42), cytosolic - rat [ R. norvegicus ] 17290 131 AA891785 E ESTs, Weakly similar to A54756 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42), cytosolic - rat [ R. norvegicus ] 22124 133 AA891790 D ESTs 20522 136 AA891842 L ESTs 20523 136 AA891842 B, L ESTs 2576 138 AA891884 K ESTs 17438 139 AA891943 GENERAL ESTs 1159 140 AA891949 GENERAL, ESTs D, I 4473 141 AA891965 GENERAL, ESTs, Highly similar to fructosamine 3 A, D, I kinase [ Mus musculus ] [ M. musculus ] 2107 143 AA892006 D, K HMm:ATPase, H+ ESTs, Highly similar to VAA1_MOUSE transporting, lysosomal Vacuolar ATP synthase catalytic subunit 70 kD, V1 subunit A, isoform 1 A, ubiquitous isoform (V-ATPase A subunit 1) (Vacuolar proton pump alpha subunit 1) (V-ATPase 69 kDa subunit 1) [ M. musculus ] 23047 145 AA892027 GENERAL ESTs 14595 147 AA892128 B, L ESTs 15666 150 AA892248 L 15667 150 AA892248 L 9073 151 AA892273 J ESTs 18190 152 AA892280 GENERAL ESTs 3474 156 AA892378 C ESTs, Weakly similar to F13B9.8.p [ Caenorhabditis elegans ] [ C. elegans ] 11991 162 AA892483 B ESTs 8599 163 AA892522 GENERAL, F ESTs 12276 164 AA892541 GENERAL, ESTs D, L 17469 166 AA892549 D ESTs 18906 167 AA892561 GENERAL, I ESTs 18275 168 AA892572 K ESTs, Highly similar to RIKEN cDNA 1110001J03 [ Mus musculus ] [ M. musculus ] 19085 170 AA892598 GENERAL ESTs, Weakly similar to putative nucleotide binding protein, estradiol- induced [ Homo sapiens ] [ H. sapiens ] 19086 170 AA892598 GENERAL ESTs, Weakly similar to putative nucleotide binding protein, estradiol- induced [ Homo sapiens ] [ H. sapiens ] 20088 171 AA892666 K ESTs 23783 172 AA892773 GENERAL, ESTs I, K 19251 173 AA892796 C ESTs 13542 174 AA892798 B ESTs 17332 177 AA892829 J HMm:3′-phosphoadenosine ESTs, Highly similar to 2204316A ATP 5′-phosphosulfate synthase 1 sulfurylase-adenosine phosphosulfate kinase [ Mus musculus ] [ M. musculus ] 18887 179 AA892860 J ESTs 9053 180 AA892861 GENERAL, I ESTs 12848 181 AA892916 H, K ESTs, Weakly similar to JC7260 strictosidine synthase (EC 4.3.3.2) homolog 2 - fruit fly ( Drosophila melanogaster ) [ D. melanogaster ] 14465 183 AA892950 K ESTs, Moderately similar to A Chain A, Crystal Structure Of The Accessory Subunit Of Murine Mitochondrial Polymerase Gamma [ M. musculus ] 3853 184 AA892999 K ESTs 3863 186 AA893060 C, D ESTs 13332 187 AA893080 GENERAL, K ESTs 21305 188 AA893082 GENERAL, ESTs D, H, I 3870 189 AA893147 F, G ESTs 17447 191 AA893192 GENERAL ESTs 17744 192 AA893206 GENERAL ESTs 3886 195 AA893289 J ESTs 9082 196 AA893357 GENERAL ESTs 17800 197 AA893436 K ESTs 4542 199 AA893643 C ESTs 9084 200 AA893717 E ESTs 2128 202 AA894008 B ESTs 2979 204 AA894099 H ESTs, Highly similar to vacuolar protein sorting protein 4a; RIKEN cDNA 4930589C15 gene [ Mus musculus ] [ M. musculus ] 21354 208 AA899721 B, L ESTs 9114 210 AA899951 GENERAL ESTs 3959 212 AA901338 GENERAL HMm:eukaryotic translation ESTs, Highly similar to eukaryotic initiation factor 2, subunit 2 translation initiation factor 2, subunit 2 (beta, 38 kDa) (beta, 38 kDa) [ Mus musculus ] [ M. musculus ] 6736 214 AA924005 C ESTs 24192 215 AA924210 H ESTs 4933 216 AA924301 GENERAL, A ESTs 3631 219 AA924460 D ESTs, Weakly similar to PMC1_MOUSE Polymyositis/scleroderma autoantigen 1 (Autoantigen PM/Scl 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) (P75 polymyositis- scleroderma overlap syndrome associated autoantigen) [ M. musculus ] 23123 222 AA924794 K ESTs 21458 224 AA925049 GENERAL ESTs 14790 225 AA925087 GENERAL ESTs 18271 228 AA925267 GENERAL, I ESTs 5129 229 AA925335 J ESTs 23978 230 AA925352 GENERAL, L ESTs 22479 231 AA925418 B, L ESTs 5183 233 AA925662 L ESTs 5205 234 AA925747 K ESTs, Highly similar to DBS_MOUSE Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2 transforming sequence-like protein) [ M. musculus ] 17157 237 AA926129 GENERAL ESTs 13411 239 AA926196 GENERAL ESTs 21513 241 AA926261 H ESTs 22928 242 AA926262 GENERAL ESTs, Moderately similar to S29993 P311 protein - mouse [ M. musculus ] 894 243 AA926305 E ESTs 6039 244 AA942716 GENERAL, G ESTs, Highly similar to hematological and neurological expressed sequence 1 [ Mus musculus ] [ M. musculus ] 23005 245 AA942770 I ESTs 21318 246 AA942774 GENERAL ESTs 22180 249 AA943202 D ESTs 21990 250 AA943524 C ESTs 12673 251 AA943773 D, L ESTs 18285 252 AA943791 F ESTs 22681 254 AA944413 GENERAL, I ESTs 6711 255 AA944439 GENERAL ESTs, Moderately similar to S60715 gene G11 protein - human [ H. sapiens ] 22536 257 AA944803 K ESTs 22501 258 AA944811 H putative zinc finger protein putative zinc finger protein SERZ-1 SERZ-1 11974 259 AA944958 GENERAL ESTs 22554 260 AA945076 GENERAL, I ESTs 22618 263 AA945656 E ESTs 22625 264 AA945704 H ESTs 22656 265 AA945818 GENERAL, H ESTs 18524 267 AA946017 D ESTs 18337 269 AA946046 GENERAL, I ESTs 22770 272 AA946428 D ESTs 17499 273 AA946467 GENERAL ESTs 9452 275 AA955206 GENERAL ESTs 23512 276 AA955282 GENERAL ESTs 19347 278 AA955334 D EST 23532 279 AA955347 E ESTs 23533 280 AA955350 E ESTs 23546 281 AA955393 I ESTs 23626 282 AA955540 D ESTs 23718 283 AA955790 A ESTs 498 284 AA956278 GENERAL ESTs 23790 286 AA956499 D ESTs 23834 287 AA956659 C ESTs 23839 288 AA956684 D ESTs 18288 289 AA956813 C ESTs, Highly similar to JC4761 recombination activating gene 1 inducing protein - mouse [ M. musculus ] 23958 292 AA957125 E ESTs 23314 294 AA957270 H, I ESTs 2702 295 AA957307 GENERAL, HMm:seryl-aminoacyl-tRNA ESTs, Highly similar to A41019 serine - I, J synthetase 1 tRNA ligase (EC 6.1.1.11) - mouse (fragment) [ M. musculus ] 24051 297 AA957452 J ESTs 17523 299 AA963240 D ESTs 24246 300 AA963703 H ESTs, Highly similar to P2G4_MOUSE Proliferation-associated protein 2G4 (Proliferation-associated protein 1) (Protein p38-2G4) [ M. musculus ] 2195 301 AA963746 GENERAL ESTs 9309 302 AA963794 E ESTs 2282 304 AA964147 F ESTs 2113 305 AA964275 D ESTs, Weakly similar to Yeast YAE2 hypothetical protein [ Caenorhabditis elegans ] [ C. elegans ] 2423 306 AA964611 D ESTs 2457 307 AA964752 L ESTs 12561 309 AA964815 GENERAL, C ESTs 11324 310 AA964832 J, L ESTs 21339 311 AA964962 J, L HMm: ATP-binding cassette, ESTs, Highly similar to ABC1_MOUSE sub-family A (ABC1), ATP-binding cassette, sub-family A, member 1 member 1 (ATP-binding cassette transporter 1) (ATP-binding cassette 1) (ABC-1) [ M. musculus ] 2563 312 AA965113 K ESTs, Weakly similar to Y54E5A.5.p [ Caenorhabditis elegans ] [ C. elegans ] 2569 313 AA965122 K ESTs, Weakly similar to T24832 hypothetical protein T11F9.11 - Caenorhabditis elegans [ C. elegans ] 2905 314 AA996727 GENERAL ESTs 2964 315 AA996954 F ESTs 3145 316 AA997237 D ESTs 12616 318 AA997599 E ESTs 3020 319 AA997656 L ESTs, Moderately similar to T09071 SH3 domains-containing protein POSH - mouse [ M. musculus ] 3269 321 AA997800 E ESTs, Moderately similar to T30249 cell proliferation antigen Ki-67 - mouse [ M. musculus ] 21959 323 AA997973 D, E ESTs 22737 327 AA998660 L ESTs 11558 328 AA998894 D ESTs 3069 329 AA998910 G ESTs, Highly similar to endoplasmic reticulum chaperone SIL1 homolog ( S. cerevisiae ) [ Mus musculus ] [ M. musculus ] 3079 330 AA999169 GENERAL ESTs 18043 335 AF020618 F myeloid differentiation myeloid differentiation primary response primary response gene 116 gene 116 11483 335 AF020618 GENERAL, I myeloid differentiation myeloid differentiation primary response primary response gene 116 gene 116 25168 336 AF030050 A replication factor C 1564 337 AF035963 E, G, K Rattus norvegicus kidney injury molecule- 1 (KIM-1) mRNA, complete cds 17426 346 AF073839 C dynein-associated protein dynein-associated protein RKM23 RKM23 2368 348 AF095741 K Mg87 protein Mg87 protein 15232 349 AI007622 D ESTs 24109 350 AI007725 J ESTs 1804 351 AI007824 L 6804 352 AI007877 GENERAL ESTs 23917 355 AI008441 H, I ESTs, Highly similar to G01922 phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) - human [ H. sapiens ] 22599 356 AI008458 GENERAL ESTs 22698 357 AI008578 L ESTs 6382 360 AI009362 GENERAL ESTs 10532 361 AI009602 K ESTs 895 362 AI009614 E ESTs 19358 363 AI009675 J EST 6833 364 AI009687 L ESTs 15089 365 AI009752 GENERAL, K ESTs 6842 366 AI009764 K ESTs 22619 367 AI009825 L ESTs 26133 368 AI009950 F EST 6869 369 AI010025 D EST 16824 370 AI010027 D ESTs 21105 371 AI010067 GENERAL, F ESTs 17938 375 AI010332 C ESTs 12095 376 AI010339 D ESTs, Weakly similar to C16C10.11.p [ Caenorhabditis elegans ] [ C. elegans ] 6916 377 AI010430 GENERAL ESTs 18657 378 AI010435 K ESTs 6927 380 AI010542 GENERAL ESTs 15679 384 AI011058 B, L ESTs 3934 385 AI011510 D ESTs 21060 390 AI011746 A ESTs 23946 393 AI012240 GENERAL ESTs 24200 394 AI012356 GENERAL, ESTs B, L 7471 395 AI012379 L ESTs 9116 396 AI012457 A, C ESTs 7127 397 AI012464 GENERAL ESTs 3493 399 AI012590 D, K ESTs 3961 400 AI012598 A ESTs, Weakly similar to S37744 endo- exonuclease yNucR - yeast ( Saccharomyces cerevisiae ) [ S. cerevisiae ] 7142 401 AI012689 C ESTs 6674 407 AI013568 I ESTs 15159 408 AI013697 D ESTs, Highly similar to RIKEN cDNA 6030432N09 [ Mus musculus ] [ M. musculus ] 7278 409 AI013738 J ESTs 15928 411 AI013829 GENERAL, K ESTs 7216 415 AI014165 A ESTs 11326 416 AI029015 F ESTs 22502 417 AI029017 H putative zinc finger protein putative zinc finger protein SERZ-1 SERZ-1 12812 418 AI029126 GENERAL, H ESTs 7537 421 AI029829 GENERAL ESTs 7586 422 AI030024 C ESTs 2370 423 AI030179 GENERAL, I ESTs 7634 424 AI030248 A ESTs, Weakly similar to RM02_YEAST 60S RIBOSOMAL PROTEIN L2, MITOCHONDRIAL PRECURSOR (YML2) (YMR6) [ S. cerevisiae ] 665 425 AI030430 B ESTs 7681 426 AI030449 J ESTs, Moderately similar to methyltransferase-like 1 ( S. cerevisiae ) [ Mus musculus ] [ M. musculus ] 11559 427 AI030472 C ESTs 17419 428 AI030524 D ESTs 7825 431 AI031023 F ESTs 14856 432 AI043721 A ESTs 7896 433 AI043772 D ESTs 7903 434 AI043805 GENERAL ESTs 10818 435 AI043990 GENERAL, I ESTs 7964 436 AI044046 G ESTs 5430 437 AI044253 F EST 5461 438 AI044338 GENERAL, B ESTs 2348 439 AI044794 GENERAL, D ESTs 5474 443 AI045477 GENERAL ESTs 10004 444 AI045509 C ESTs 17755 445 AI045608 C, I ESTs 26173 446 AI045626 F 5855 447 AI045669 GENERAL ESTs 23712 448 AI045827 L ESTs, Weakly similar to T00043 BH- protocadherin-a - mouse [ M. musculus ] 5900 449 AI045866 I ESTs 5329 451 AI045970 GENERAL ESTs 8065 453 AI058509 B, L ESTs 8104 454 AI058655 B EST 8143 455 AI058759 GENERAL ESTs 4789 456 AI058889 GENERAL ESTs 8202 457 AI058990 L ESTs 8283 458 AI059290 H ESTs 6343 461 AI070108 A ESTs 14424 463 AI070421 GENERAL ESTs 10434 464 AI070497 B ESTs 8927 465 AI070523 A ESTs, Highly similar to RIKEN cDNA 1810020G14 [ Mus musculus ] [ M. musculus ] 8946 467 AI070611 A ESTs 10446 468 AI070638 B ESTs 9026 470 AI070944 L EST 8721 471 AI071024 GENERAL, EST A, D, I 9212 472 AI071098 K ESTs 18792 473 AI071177 GENERAL, I ESTs 9583 474 AI071185 GENERAL, ESTs C, L 9079 475 AI071251 B, I ESTs, Moderately similar to A57050 K- glypican precursor - mouse [ M. musculus ] 11057 476 AI071509 L ESTs 22929 477 AI071578 GENERAL, F ESTs, Moderately similar to S29993 P311 protein - mouse [ M. musculus ] 22930 477 AI071578 GENERAL ESTs, Moderately similar to S29993 P311 protein - mouse [ M. musculus ] 9673 478 AI071581 GENERAL, I ESTs 8099 479 AI071586 B ESTs 11075 480 AI071639 F EST 9699 481 AI071646 GENERAL ESTs 9781 482 AI071943 GENERAL, I EST 12846 484 AI072068 J ESTs 10849 486 AI072189 F ESTs 20003 487 AI072362 GENERAL ESTs 16813 491 AI072746 I EST 21885 492 AI072886 GENERAL ESTs 9439 493 AI072934 J ESTs 9468 494 AI073021 GENERAL ESTs 24165 495 AI101113 F ESTs 17743 497 AI101660 J ESTs 4119 498 AI101901 L ESTs 2824 499 AI101999 C ESTs 19011 504 AI102618 L ESTs 23837 505 AI102620 GENERAL ESTs 6796 509 AI102753 GENERAL, B ESTs 8837 510 AI102849 C ESTs 3584 511 AI103106 E ESTs 13028 513 AI103253 A ESTs 7622 514 AI103472 A ESTs 20918 515 AI103552 J ESTs 4856 516 AI103708 G ESTs 22885 519 AI103828 GENERAL, B ESTs 7128 521 AI103937 GENERAL ESTs 22271 522 AI103947 F ESTs, Moderately similar to mitochondrial ribosomal protein L36 [ Mus musculus ] [ M. musculus ] 12450 523 AI103955 C LRP16 protein Rattus norvegicus LRP16-like protein mRNA, complete cds 22101 525 AI104251 GENERAL, ESTs, Moderately similar to C, I DKFZP564O243 protein [ Homo sapiens ] [ H. sapiens ] 12798 527 AI104773 GENERAL ESTs, Highly similar to hypothetical protein KIAA1695; hypothetical protein FLJ22297; KIAA1695 protein [ Homo sapiens ] [ H. sapiens ] 11232 528 AI104864 F ESTs, Moderately similar to hypothetical protein MGC3037 [ Homo sapiens ] [ H. sapiens ] 16887 529 AI104883 F ESTs 5199 532 AI105272 GENERAL, G ESTs, Weakly similar to T21641 hypothetical protein F32B6.2 - Caenorhabditis elegans [ C. elegans ] 7049 533 AI105371 C ESTs 13343 535 AI105398 GENERAL ESTs 17221 536 AI105429 K ESTs 4479 539 AI111599 GENERAL ESTs 12925 541 AI111970 B ESTs 9017 542 AI112138 GENERAL ESTs 11198 543 AI112199 F ESTs 12945 544 AI112212 F ESTs 3713 545 AI112571 GENERAL, J ESTs 13013 547 AI136233 B ESTs 13020 548 AI136338 F ESTs, Weakly similar to S36152 MHC class III histocompatibility antigen HLA-B- associated protein 2 [similarity] - human [ H. sapiens ] 11937 552 AI137218 I ESTs, Moderately similar to hypothetical protein MGC2835 [ Homo sapiens ] [ H. sapiens ] 5290 554 AI137227 D ESTs 14142 555 AI137435 K ESTs 6638 556 AI137579 GENERAL ESTs 2264 559 AI144741 F ESTs 14458 560 AI145095 GENERAL ESTs 8339 562 AI145761 GENERAL ESTs, Weakly similar to T21659 hypothetical protein F32D8.4 - Caenorhabditis elegans [ C. elegans ] 5531 563 AI145859 F ESTs 18522 564 AI145870 A, F, I ESTs, Moderately similar to RIKEN cDNA 1110025H10 [ Mus musculus ] [ M. musculus ] 11618 568 AI169115 GENERAL, ESTs C, F, I 5920 569 AI169163 B ESTs 12979 570 AI169177 GENERAL, ESTs, Highly similar to S33363 gly96 B, H, I, L protein - mouse [ M. musculus ] 16338 572 AI169374 D ESTs 8234 573 AI169517 B ESTs 24592 574 AI169622 D Serine protease inhibitor, Serine protease inhibitor, kanzal type 1/ kanzal type 1/Trypsin Trypsin inhibitor-like protein, pancreatic inhibitor-like protein, pancreatic 10839 575 AI169655 G ESTs 11429 576 AI169706 H ESTs 3916 577 AI169947 GENERAL, I ESTs 16898 578 AI170249 B ESTs, Weakly similar to T29643 hypothetical protein F49E8.1 - Caenorhabditis elegans [ C. elegans ] 5297 579 AI170379 GENERAL, D ESTs 2534 580 AI170632 D, K ESTs 10130 582 AI170759 GENERAL, ESTs A, I 3803 583 AI170773 A Rattus norvegicus 250 kDa estrous- specific protein mRNA, partial cds 22985 584 AI171093 A, F ESTs 736 585 AI171314 G ESTs, Weakly similar to B Chain B, Solution Structure Of The C-Terminal Negative Regulatory Domain Of P53 In A Complex With Ca2+-Bound S100b(Bb) [ R. norvegicus ] 11761 587 AI171526 A ESTs 10087 589 AI171803 GENERAL methylmalonate methylmalonate semialdehyde semialdehyde dehydrogenase gene dehydrogenase gene 11708 590 AI171807 GENERAL ESTs 22747 591 AI171832 GENERAL ESTs, Highly similar to RIKEN cDNA 2410005O16 [ Mus musculus ] [ M. musculus ] 21956 592 AI171980 L ESTs 11205 593 AI172057 G ESTs 3698 595 AI172193 C ESTs 18681 596 AI172206 J ESTs 15382 598 AI172302 GENERAL, H ESTs, Weakly similar to S43056 hypothetical protein - mouse [ M. musculus ] 17887 599 AI172414 J brain protein 44-like brain protein 44-like 13106 600 AI172615 D ESTs 13457 601 AI175319 F ESTs 22311 604 AI176007 B ESTs, Highly similar to PM5P_HUMAN Protein pM5 precursor [ H. sapiens ] 21088 609 AI176472 A ESTs 24236 610 AI176473 GENERAL ESTs 18418 611 AI176483 D ESTs 23299 613 AI176839 GENERAL ESTs 22103 614 AI176849 L ESTs 15146 615 AI176969 GENERAL, K ESTs 23018 617 AI177093 D ESTs 15964 620 AI177360 GENERAL, ESTs A, B, H, I, K, L 4987 623 AI177428 F ESTs 18095 624 AI177482 D SH-PTP2 protein tyrosine SH-PTP2 protein tyrosine phosphatase, phosphatase, non-receptor non-receptor type 11 type 11 150 625 AI177510 F ESTs 14425 627 AI177755 GENERAL, L ESTs, Moderately similar to PBEF_HUMAN Pre-B cell enhancing factor precursor [ H. sapiens ] 5929 630 AI177962 E ESTs, Moderately similar to S23251 protein-tyrosine kinase (EC 2.7.1.112) ark precursor - mouse [ M. musculus ] 18996 633 AI178326 J ESTs, Highly similar to hypothetical protein MGC4175 [ Homo sapiens ] [ H. sapiens ] 8445 634 AI178394 J ESTs 22197 635 AI178527 GENERAL, H ESTs 8477 638 AI179167 GENERAL ESTs 13614 641 AI179407 B, L ESTs, Moderately similar to RB17_MOUSE Ras-related protein Rab- 17 [ M. musculus ] 15042 642 AI179422 GENERAL ESTs 5901 644 AI179605 D ESTs 6765 648 AI227761 GENERAL, ESTs, Highly similar to EFER_HUMAN H, I Eferin [ H. sapiens ] 6487 649 AI227919 GENERAL ESTs 19188 650 AI227938 G, J ESTs 15879 653 AI228313 GENERAL, K ESTs 13727 654 AI228326 GENERAL, A ESTs, Weakly similar to S30825 AFG1 protein - yeast ( Saccharomyces cerevisiae ) [ S. cerevisiae ] 6102 655 AI228335 L ESTs 17892 656 AI228438 H ESTs 13740 657 AI228455 A ESTs, Moderately similar to KIAA0943 protein [ Homo sapiens ] [ H. sapiens ] 13176 659 AI228654 GENERAL ESTs 22328 660 AI229142 GENERAL ESTs 6886 662 AI229332 F ESTs 23435 663 AI229502 H, I ESTs 9035 666 AI229879 F, J ESTs 11866 667 AI229966 F ESTs, Weakly similar to T29947 hypothetical protein T20D4.7 - Caenorhabditis elegans [ C. elegans ] 24042 669 AI230002 C ESTs 12551 670 AI230056 C, K ESTs 6629 671 AI230165 D ESTs, Weakly similar to Deoxyribose- phosphate aldolase [ Caenorhabditis elegans ] [ C. elegans ] 14450 673 AI230262 B ESTs 18528 674 AI230284 K ESTs 20895 675 AI230549 H ESTs 12961 676 AI230554 GENERAL ESTs 18529 677 AI230716 GENERAL, K ESTs 21648 680 AI230880 J ESTs, Highly similar to AR21_HUMAN ARP2/3 complex 21 kDa subunit (P21- ARC) (Actin-related protein 2/3 complex subunit 3) [ H. sapiens ] 16087 681 AI231011 F ESTs 13934 683 AI231044 F ESTs 13966 687 AI231421 B ESTs 12343 688 AI231433 C ESTs 14020 691 AI232076 GENERAL ESTs 12366 693 AI232088 F ESTs 15955 696 AI232294 GENERAL, ESTs G, I 15246 697 AI232332 D ESTs 16172 699 AI232341 K ESTs, Weakly similar to C13B9.2.p [ Caenorhabditis elegans ] [ C. elegans ] 11157 701 AI232494 K ESTs 4440 702 AI232643 GENERAL, I ESTs 7285 703 AI232731 GENERAL ESTs, Weakly similar to E. coli YCAC like [ Caenorhabditis elegans ] [ C. elegans ] 12467 705 AI232924 GENERAL ESTs 11967 707 AI233155 GENERAL, J ESTs 14120 710 AI233433 K ESTs 19509 711 AI233437 L ESTs 14095 712 AI233468 GENERAL, I ESTs 14131 713 AI233493 L ESTs 6046 714 AI233530 GENERAL, ESTs B, I, L 7804 717 AI233771 K ESTs 535 720 AI233916 E ESTs 8325 721 AI234293 E ESTs 14677 722 AI234620 GENERAL, ESTs G, K, L 22213 723 AI234858 K ESTs, Highly similar to splicing factor 3b, subunit 3, 130 kD; spliceosome- associated protein 130 [ Homo sapiens ] [ H. sapiens ] 26319 724 AI234887 H ESTs, Weakly similar to serine/threonine kinase [ Caenorhabditis elegans ] [ C. elegans ] 8850 728 AI235059 B ESTs 6632 730 AI235277 C ESTs 896 731 AI235313 E ESTs 7937 732 AI235414 B ESTs 21061 734 AI235631 GENERAL, A ESTs 15836 737 AI235951 A ESTs, Moderately similar to N4BM_HUMAN NADH-ubiquinone oxidoreductase subunit B14.5b (Complex I-B14.5b) (CI-B14.5b) [ H. sapiens ] 3091 738 AI236027 GENERAL, ESTs A, C, H, I 14867 739 AI236061 GENERAL ESTs 22855 740 AI236150 A ESTs, Highly similar to JC7301 Down syndrome critical region protein 5 alpha - human [ H. sapiens ] 17950 743 AI236590 L ESTs 18259 744 AI236601 H ESTs 2574 745 AI236616 F ESTs 16859 746 AI236753 GENERAL, D ESTs 24388 748 AI236772 GENERAL, K ESTs 18303 750 AI236863 GENERAL Rattus norvegicus retinol dehydrogenase type II mRNA, complete cds 19890 751 AI237108 F ESTs 8759 755 AI237646 B, L ESTs 6127 757 AI638960 A ESTs 20000 759 AI638989 A, B ESTs, Moderately similar to T14273 zinc finger protein 106 - mouse [ M. musculus ] 23781 760 AI639012 F ESTs, Weakly similar to hypothetical protein MGC2601 [ Homo sapiens ] [ H. sapiens ] 10071 761 AI639058 F ESTs, Highly similar to Nedd4 WW binding# protein 4; Nedd4 WW-binding protein 4 [ Mus musculus ] [ M. musculus ] 25902 763 AI639154 H EST 15379 765 AI639162 B ESTs 25921 766 AI639209 A, F 15330 767 AI639285 GENERAL, ESTs F, I 21542 769 AI639476 J ESTs 20056 772 AI639504 GENERAL, I ESTs, Weakly similar to T13607 hypothetical protein 87B1.3 - fruit fly ( Drosophila melanogaster ) [ D. melanogaster ] 25235 776 AJ001290 F solute carrier family 5 (inositol transporters), member 3 24033 786 H33101 H ESTs 20149 794 K03243 F 25364 796 L13237 F 25366 798 L14003 J 18629 802 L40362 G Rattus norvegicus MHC class I RT1.C- type protein mRNA, complete cds 25399 804 M13101 F 17274 806 M18854 J Rat T-cell receptor active beta-chain C- region mRNA, partial cds, clone TRB4 25415 807 M19648 G 20481 808 M22631 GENERAL, Propionyl Coenzyme A G, K carboxylase, alpha polypeptide 25419 809 M22922 G 25470 820 M95791 E 4529 836 NM_012647 GENERAL Rattus norvegicus Sodium ESTs channel, voltage-gated, type II, alpha polypeptide (Scn2a1), mRNA. Length = 8553 24590 838 NM_012674 D Rattus norvegicus Serine Serine protease inhibitor, kanzal type 1/ protease inhibitor, kanzal Trypsin inhibitor-like protein, pancreatic type 1/Trypsin inhibitor-like protein, pancreatic (Spink1), mRNA. Length = 2338 11136 856 NM_012839 J Rattus norvegicus Cytochrome C, expressed in somatic tissues (Cycs), mRNA. Length = 318 26083 879 NM_013038 B, H Rattus norvegicus Syntaxin binding protein 1 (Stxbp1), mRNA. Length = 3226 14996 883 NM_013059 GENERAL, D Rattus norvegicus Tissue- Tissue-nonspecific ALP alkaline nonspecific ALP alkaline phosphatase phosphatase (Alpl), mRNA. Length = 2415 21193 889 NM_013104 F Rattus norvegicus Insulin-like growth factor binding protein 6 (lgfbp6), mRNA. Length = 970 25567 897 NM_013156 GENERAL, I Rattus norvegicus Cathepsin L (Ctsl), mRNA. Length = 1386 25546 908 NM_017023 K Rattus norvegicus Potassium inwardly-rectifying channel, subfamily J (Kcnj1), mRNA. Length = 2069 18967 936 NM_017222 H Rattus norvegicus solute ESTs carrier family 10, member 2 (Slc10a2), mRNA. Length = 4269 16150 953 NM_017340 G Rattus norvegicus acyl-coA acyl-coA oxidase oxidase (RATACOA1), mRNA. Length = 3741 19930 994 NM_021745 F Rattus norvegicus famesoid EST X activated receptor (LOC60351), mRNA. Length = 2070 20167 999 NM_021863 E Rattus norvegicus testis- testis-specific heat shock protein-related specific heat shock protein- gene hst70 related gene hst70 (Hspt70), mRNA. Length = 1902 21072 1022 NM_022601 K Rattus norvegicus pyridoxine pyridoxine 5′-phosphate oxidase 5′-phosphate oxidase (U91561), mRNA. Length = 1686 2812 1037 NM_024386 J Rattus norvegicus 3-hydroxy- 3-hydroxy-3-methylglutaryl CoA lyase 3-methylglutaryl CoA lyase (Hmgcl), mRNA. Length = 1390 25453 1046 NM_030985 GENERAL, L Rattus norvegicus Angiotensin II receptor, type 1 (AT1A) (Agtr1a), mRNA. Length = 1450 7872 1046 NM_030985 GENERAL, B Rattus norvegicus ESTs Angiotensin II receptor, type 1 (AT1A) (Agtr1a), mRNA. Length = 1450 17269 1051 NM_031057 GENERAL Rattus norvegicus methylmalonate semialdehyde methylmalonate dehydrogenase gene semialdehyde dehydrogenase gene (Mmsdh), mRNA. Length = 2059 25862 1071 NM_031357 A Rattus norvegicus ceroid- lipofuscinosis, neuronal 2 (Cln2), mRNA. Length = 2485 26183 1071 NM_031357 A Rattus norvegicus ceroid- lipofuscinosis, neuronal 2 (Cln2), mRNA. Length = 2485 25069 1072 NM_031509 H Rattus norvegicus Glutathione-S-transferase, alpha type (Ya) (Gsta1), mRNA. Length = 1178 16245 1073 NM_031523 G Rattus norvegicus Nerve growth factor, gamma polypeptide (Ngfg), mRNA. Length = 873 11755 1075 NM_031533 B, H Rattus norvegicus Androsterone UDP- glucuronosyltransferase (Ugt2b2), mRNA. Length = 1593 1807 1092 NM_031693 L Rattus norvegicus synaptotagmin 4 (Syt4), mRNA. Length = 2060 25469 1123 NM_033234 J Rattus norvegicus Hemoglobin, beta (Hbb), mRNA. Length = 620 1553 1127 NM_052802 J Rattus norvegicus Kidney Kidney androgen-regulated protein androgen-regulated protein (Kap), mRNA. Length = 704 20708 1142 NM_053543 A Rattus norvegicus neurochondrin neurochondrin (Ncdn- pending), mRNA. Length = 3730 3049 1146 NM_053582 GENERAL Rattus norvegicus glucocorticoid-inducible protein glucocorticoid-inducible protein (gis5), mRNA. Length = 1869 3050 1146 NM_053582 GENERAL Rattus norvegicus glucocorticoid-inducible protein glucocorticoid-inducible protein (gis5), mRNA. Length = 1869 968 1178 NM_057133 G, K Rattus norvegicus nuclear nuclear receptor subfamily 0, group B, receptor subfamily 0, group member 2 B, member 2 (Nr0b2), mRNA. Length = 1111 20694 1193 NM_130430 GENERAL, I Rattus norvegicus ESTs proteasome (prosome, macropain) 26S subunit, non- ATPase, 9 (Psmd9), mRNA. Length = 1448 25064 1194 S45392 H, K 3244 1196 S63519 GENERAL ESTs 9224 1198 S70011 C ESTs, Weakly similar to T19996 hypothetical protein C47D12.3 - Caenorhabditis elegans [ C. elegans ] 25547 1200 S78556 C 25550 1201 S79213 J protein phosphatase 1, regulatory (inhibitor) subunit 2 9520 1209 U17837 B ESTs 25589 1213 U21718 F 22196 1214 U21719 GENERAL ESTs 18301 1218 U33500 GENERAL Rattus norvegicus retinol dehydrogenase type II mRNA, complete cds 18302 1218 U33500 GENERAL Rattus norvegicus retinol dehydrogenase type II mRNA, complete cds 25606 1222 U53214 C tubulin tyrosine ligase tubulin tyrosine ligase 4956 1228 U76714 H solute carrier family 39 (iron- solute carrier family 39 (iron-regulated regulated transporter), transporter), member 1 member 1 25643 1229 U77829 A growth arrest specific 5 25647 1230 U83119 F 25662 1234 X05472 F 25691 1239 X53504 G 25692 1240 X53581 D 20617 1240 X53581 F 25705 1245 X59375 GENERAL, J 16012 1251 X62875 GENERAL, I high mobility group AT-hook 1 ESTs, Highly similar to A31895 nonhistone chromosomal protein HMG- I(Y) - mouse [ M. musculus ] 25747 1253 X81448 GENERAL, keratin complex 1, acidic, C, K gene 18 12978 1254 X96437 GENERAL, ESTs, Highly similar to S33363 gly96 H, I protein - mouse [ M. musculus ] 25777 1255 Y08355 GENERAL, oxidative stress induced oxidative stress induced A, F, I






TABLE 2





PATHWAYS



Atty. Docket No. GENE-077/26US

Doc. No. 44941







GLGC
Seq
GenBank Acc or



Identifier
ID
RefSeq ID
Model Code
Pathways









20414
799
L14323
GENERAL
Activation of PKC through G protein coupled receptor, CCR3





signaling in Eosinophils, G-Protein Signaling Through Tubby





Proteins, Inositol phosphate metabolism, PKC-catalyzed





phosphorylation of inhibitory phosphoprotein of myosin





phosphatase, Phosphatidylinositol signaling system,





Phospholipase C Signaling Pathway, Regulation of ck1/cdk5 by





type 1 glutamate receptors, Thrombin signaling and protease-





activated receptors

2554
873
NM_012967
GENERAL
Adhesion Molecules on Lymphocyte, B Lymphocyte Cell Surface





Molecules, CTL mediated immune response against target cells,





Cells and Molecules involved in local acute inflammatory





response, Monocyte and its Surface Molecules, Neutrophil and Its





Surface Molecules, T Cytotoxic Cell Surface Molecules, T Helper





Cell Surface Molecules

2555
873
NM_012967
GENERAL, C, I
Adhesion Molecules on Lymphocyte, B Lymphocyte Cell Surface





Molecules, CTL mediated immune response against target cells,





Cells and Molecules involved in local acute inflammatory





response, Monocyte and its Surface Molecules, Neutrophil and Its





Surface Molecules, T Cytotoxic Cell Surface Molecules, T Helper





Cell Surface Molecules

14989
621
AI177366
GENERAL, K
Adhesion Molecules on Lymphocyte, Cells and Molecules





involved in local acute inflammatory response, Erk and PI-3





Kinase Are Necessary for Collagen Binding in Corneal Epithelia,





Erk1/Erk2 Mapk Signaling pathway, Integrin Signaling Pathway,





Monocyte and its Surface Molecules, PTEN dependent cell cycle





arrest and apoptosis, Ras-Independent pathway in NK cell-





mediated cytotoxicity

16684
882
NM_013052
GENERAL
AKT Signaling Pathway, Cell Cycle: G2/M Checkpoint, Control of





skeletal myogenesis by HDAC & calcium/calmodulin-dependent





kinase (CaMK), Multiple antiapoptotic pathways from IGF-1R





signaling lead to BAD phosphphorylation, RB Tumor





Suppressor/Checkpoint Signaling in response to DNA damage,





Regulation of BAD phosphorylation, Role of nicotinic acetylcholine





receptors in the regulation of apoptosis, Signal Dependent





Regulation of Myogenesis by Corepressor MITR, cdc25 and chk1





Regulatory Pathway in response to DNA damage

17524
381
AI010568
GENERAL, A, I
AKT Signaling Pathway, Growth Hormone Signaling Pathway,





Regulation of eIF4e and p70 S6 Kinase

10887
917
NM_017094
GENERAL, I
AKT Signaling Pathway, Growth Hormone Signaling Pathway,





Regulation of eIF4e and p70 S6 Kinase

4234
1068
NM_031330
K
Alanine and aspartate metabolism, Arginine and proline





metabolism, Urea cycle and metabolism of amino groups

1478
843
NM_012744
GENERAL
Alanine and aspartate metabolism, Citrate cycle (TCA cycle),





Pyruvate metabolism

1479
843
NM_012744
D
Alanine and aspartate metabolism, Citrate cycle (TCA cycle),





Pyruvate metabolism

1430
816
M84648
GENERAL
Alkaloid biosynthesis I, Histidine metabolism, Phenylalanine





metabolism, Tryptophan metabolism, Tyrosine metabolism

1431
824
NM_012545
D
Alkaloid biosynthesis I, Histidine metabolism, Phenylalanine





metabolism, Tryptophan metabolism, Tyrosine metabolism

7489
963
NM_019169
GENERAL, G, I,
Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's




J, L
disease, Role of Parkin in Ubiquitin-Proteasomal Pathway

16756
38
AA818089
GENERAL, A, I
Aminoacyl-tRNA biosynthesis, Glycine, serine and threonine





metabolism

12031
201
AA893860
GENERAL, I
Aminoacyl-tRNA biosynthesis, Glycine, serine and threonine





metabolism

2702
295
AA957307
GENERAL, I, J
Aminoacyl-tRNA biosynthesis, Glycine, serine and threonine





metabolism

1515
1053
NM_031095
J
Aminosugars metabolism

25070
1038
NM_024392
GENERAL
Androgen and estrogen metabolism

275
914
NM_017081
GENERAL
Androgen and estrogen metabolism, C21-Steroid hormone





metabolism

14633
1075
NM_031533
H
Androgen and estrogen metabolism, Pentose and glucuronate





interconversions, Porphyrin and chlorophyll metabolism, Starch





and sucrose metabolism

15124
1175
NM_057105
B
Androgen and estrogen metabolism, Pentose and glucuronate





interconversions, Porphyrin and chlorophyll metabolism, Starch





and sucrose metabolism

15125
1175
NM_057105
B
Androgen and estrogen metabolism, Pentose and glucuronate





interconversions, Porphyrin and chlorophyll metabolism, Starch





and sucrose metabolism

11755
1075
NM_031533
B, H
Androgen and estrogen metabolism, Pentose and glucuronate





interconversions, Porphyrin and chlorophyll metabolism, Starch





and sucrose metabolism

17907
708
AI233224
GENERAL
Angiotensin II mediated activation of JNK Pathway via Pyk2





dependent signaling, EGF Signaling Pathway, Erk1/Erk2 Mapk





Signaling pathway, egf

11137
856
NM_012839
J
Apoptotic Signaling in Response to DNA Damage, Caspase





Cascade in Apoptosis, D4-GDI Signaling Pathway, Electron -





Transfer Reaction in Mitochondria, HIV-I Nef: negative effector of





Fas and TNF, Induction of apoptosis through DR3 and DR4/5





Death Receptors, Role of Mitochondria in Apoptotic Signaling

16116
1105
NM_031775
F
Apoptotic Signaling in Response to DNA Damage, Caspase





Cascade in Apoptosis, FAS signaling pathway (CD95), HIV-I Nef:





negative effector of Fas and TNF, Induction of apoptosis through





DR3 and DR4/5 Death Receptors, Role of Mitochondria in





Apoptotic Signaling

16884
517
AI103758
E
Arginine and proline metabolism, Ascorbate and aldarate





metabolism, Bile acid biosynthesis, Butanoate metabolism, Fatty





acid metabolism, Glycerolipid metabolism, Glycolysis/





Gluconeogenesis, Histidine metabolism, Lysine degradation,





Propanoate metabolism, Pyruvate metabolism, Tryptophan





metabolism, Valine, leucine and isoleucine degradation, beta-





Alanine metabolism

16885
531
AI105188
K
Arginine and proline metabolism, Ascorbate and aldarate





metabolism, Bile acid biosynthesis, Butanoate metabolism, Fatty





acid metabolism, Glycerolipid metabolism, Glycolysis/





Gluconeogenesis, Histidine metabolism, Lysine degradation,





Propanoate metabolism, Pyruvate metabolism, Tryptophan





metabolism, Valine, leucine and isoleucine degradation, beta-





Alanine metabolism

23884
1099
NM_031731
J
Arginine and proline metabolism, Ascorbate and aldarate





metabolism, Bile acid biosynthesis, Butanoate metabolism, Fatty





acid metabolism, Glycerolipid metabolism, Glycolysis/





Gluconeogenesis, Histidine metabolism, Lysine degradation,





Propanoate metabolism, Pyruvate metabolism, Tryptophan





metabolism, Valine, leucine and isoleucine degradation, beta-





Alanine metabolism

16948
850
NM_012793
A, C
Arginine and proline metabolism, Glycine, serine and threonine





metabolism, Urea cycle and metabolism of amino groups

16775
1048
NM_031031
GENERAL, D, I, L
Arginine and proline metabolism, Glycine, serine and threonine





metabolism, Urea cycle and metabolism of amino groups

25467
818
M93297
G
Arginine and proline metabolism, Urea cycle and metabolism of





amino groups

22352
603
AI175959
GENERAL, H
ATM Signaling Pathway, Angiotensin II mediated activation of JNK





Pathway via Pyk2 dependent signaling, BCR Signaling Pathway,





D4-GDI Signaling Pathway, EGF Signaling Pathway, EPO





Signaling Pathway, FAS signaling pathway (CD95), Fc Epsilon





Receptor I Signaling in Mast Cells, Hypoxia-Inducible Factor in the





Cardiovascular System, IGF-1 Signaling Pathway, IL 2 signaling





pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation





by Gleevec, Insulin Signaling Pathway, Integrin Signaling





Pathway, Links between Pyk2 and Map Kinases, MAPKinase





Signaling Pathway, Nerve growth factor pathway (NGF), PDGF





Signaling Pathway, Pertussis toxin-insensitive CCR5 Signaling in





Macrophage, Repression of Pain Sensation by the Transcriptional





Regulator DREAM, Signal transduction through IL1R, Signaling





Pathway from G-Protein Families, T Cell Receptor Signaling





Pathway, TNF/Stress Related Signaling, TNFR1 Signaling





Pathway, TPO Signaling Pathway, TSP-1 Induced Apoptosis in





Microvascular Endothelial Cell, The 41BB-dependent immune









352
1030
NM_024127
H
ATM Signaling Pathway, Cell Cycle: G2/M Checkpoint, Hypoxia





and p53 in the Cardiovascular system, p53 Signaling Pathway

353
1030
NM_024127
GENERAL, H, I
ATM Signaling Pathway, Cell Cycle: G2/M Checkpoint, Hypoxia





and p53 in the Cardiovascular system, p53 Signaling Pathway

354
1030
NM_024127
GENERAL, H, I
ATM Signaling Pathway, Cell Cycle: G2/M Checkpoint, Hypoxia





and p53 in the Cardiovascular system, p53 Signaling Pathway

22662
725
AI234939
GENERAL
ATP Synthesis, Oxidative phosphorylation

2107
143
AA892006
D, K
ATP Synthesis, Oxidative phosphorylation

20725
1149
NM_053602
A
ATP Synthesis, Oxidative phosphorylation, Purine metabolism

21562
1185
NM_078623
A
Benzoate degradation, Butanoate metabolism, Fatty acid





biosynthesis (path 2), Fatty acid metabolism, Lysine degradation,





Propanoate metabolism, Tryptophan metabolism, Valine, leucine





and isoleucine degradation, beta-Alanine metabolism

15175
1091
NM_031682
E
Benzoate degradation, Butanoate metabolism, Fatty acid





biosynthesis (path 2), Fatty acid metabolism, Lysine degradation,





Tryptophan metabolism, Valine, leucine and isoleucine





degradation

23698
821
NM_012489
D
Bile acid biosynthesis, Fatty acid biosynthesis (path 2), Fatty acid





metabolism, Valine, leucine and isoleucine degradation

23699
821
NM_012489
D, E
Bile acid biosynthesis, Fatty acid biosynthesis (path 2), Fatty acid





metabolism, Valine, leucine and isoleucine degradation

22219
972
NM_019286
F
Bile acid biosynthesis, Fatty acid metabolism, Glycerolipid





metabolism, Glycolysis/Gluconeogenesis, Tyrosine metabolism

13939
933
NM_017212
D
Bioactive Peptide Induced Signaling Pathway

13940
933
NM_017212
D
Bioactive Peptide Induced Signaling Pathway

2812
1037
NM_024386
J
Butanoate metabolism, Synthesis and degradation of ketone





bodies, Valine, leucine and isoleucine degradation

165
561
AI145329
F
Carbon fixation, Citrate cycle (TCA cycle), Glyoxylate and





dicarboxylate metabolism, Pyruvate metabolism, Reductive





carboxylate cycle (CO2 fixation)

1312
1130
NM_053291
J
Carbon fixation, Glycolysis/Gluconeogenesis, Glycolysis





Pathway

20802
1018
NM_022592
H
Carbon fixation, Pentose phosphate pathway

20803
1018
NM_022592
B, H, I
Carbon fixation, Pentose phosphate pathway

20804
1018
NM_022592
H
Carbon fixation, Pentose phosphate pathway

20086
403
AI013260
GENERAL, H
Caspase Cascade in Apoptosis, FAS signaling pathway (CD95),





HIV-I Nef: negative effector of Fas and TNF, Induction of





apoptosis through DR3 and DR4/5 Death Receptors, TNFR1





Signaling Pathway

20085
997
NM_021755
C
Caspase Cascade in Apoptosis, FAS signaling pathway (CD95),





HIV-I Nef: negative effector of Fas and TNF, Induction of





apoptosis through DR3 and DR4/5 Death Receptors, TNFR1





Signaling Pathway

5206
235
AA925755
E
Catabolic Pathways for Arginine, Histidine, Glutamate, Glutamine,





and Proline, D-Glutamine and D-glutamate metabolism,





Glutamate metabolism, Nitrogen metabolism

291
822
NM_012522
GENERAL, F
Catabolic Pathways for Methionine, Isoleucine, Threonine and





Valin, Glycine, serine and threonine metabolism, Methionine





metabolism, Selenoamino acid metabolism

15364
921
NM_017147
J
CCR3 signaling in Eosinophils, Rac 1 cell motility signaling





pathway, Rho cell motility signaling pathway

11434
778
D14014
B
Cell Cycle: G1/S Check Point, Cyclins and Cell Cycle Regulation,





Inactivation of Gsk3 by AKT causes accumulation of b-catenin in





Alveolar Macrophages, Influence of Ras and Rho proteins on G1





to S Transition, WNT Signaling Pathway, p53 Signaling Pathway

24232
1252
X75207
B
Cell Cycle: G1/S Check Point, Cyclins and Cell Cycle Regulation,





Inactivation of Gsk3 by AKT causes accumulation of b-catenin in





Alveolar Macrophages, Influence of Ras and Rho proteins on G1





to S Transition, WNT Signaling Pathway, p53 Signaling Pathway

21165
1047
NM_031005
K
Cell to Cell Adhesion Signaling, Integrin Signaling Pathway

21166
1047
NM_031005
K
Cell to Cell Adhesion Signaling, Integrin Signaling Pathway

6758
405
AI013394
B, L
Chondroitin/Heparan sulfate biosynthesis

17516
950
NM_017321
A, E, L
Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate





metabolism, Reductive carboxylate cycle (CO2 fixation)

19991
1169
NM_053961
K
Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate





metabolism, Reductive carboxylate cycle (CO2 fixation)

17514
232
AA925554
E, G
Citrate cycle (TCA cycle), Oxidative phosphorylation

15851
1219
U42719
GENERAL
Classic Complement Pathway, Complement Pathway, Lectin





Induced Complement Pathway

21053
805
M15481
GENERAL
Control of skeletal myogenesis by HDAC & calcium/calmodulin-





dependent kinase (CaMK), Erythrocyte Differentiation Pathway,





IGF-1 Signaling Pathway, Regulation of BAD phosphorylation,





Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway,





igf-1

24321
698
AI232340
GENERAL, K, L
CXCR4 Signaling Pathway, Pertussis toxin-insensitive CCR5





Signaling in Macrophage

16354
782
D50564
C
Cysteine metabolism

17807
909
NM_017025
GENERAL, G
Cysteine metabolism, Glycolysis/Gluconeogenesis, Hypoxia-





Inducible Factor in the Cardiovascular System, Propanoate





metabolism, Pyruvate metabolism

7124
829
NM_012595
E
Cysteine metabolism, Glycolysis/Gluconeogenesis, Propanoate





metabolism, Pyruvate metabolism

18452
913
NM_017074
GENERAL
Cysteine metabolism, Methionine metabolism, Nitrogen





metabolism, Selenoamino acid metabolism

18453
913
NM_017074
G
Cysteine metabolism, Methionine metabolism, Nitrogen





metabolism, Selenoamino acid metabolism

15028
1129
NM_052809
F
Cysteine metabolism, Taurine and hypotaurine metabolism

20884
857
NM_012842
G, K
EGF Signaling Pathway, egf

20885
857
NM_012842
G, K
EGF Signaling Pathway, egf

25233
774
AJ000556
E
EGF Signaling Pathway, IFN alpha signaling pathway, IFN





gamma signaling pathway, IL 2 signaling pathway, IL 4 signaling





pathway, IL-2 Receptor B Protein Interaction Pathway, PDGF





Signaling Pathway, egf, ifn_alpha, ifn_gamma, il2, il4, il6, interact6





1, pdgf

2629
830
NM_012603
K
Erk1/Erk2 Mapk Signaling pathway, IL-2 Receptor B Protein





Interaction Pathway, Inhibition of Cellular Proliferation by Gleevec,





Neuropeptides VIP and PACAP inhibit the apoptosis of activated T





cells, Overview of telomerase protein component gene hTert





Transcriptional Regulation, WNT Signaling Pathway, p38 MAPK





Signaling Pathway

15926
1150
NM_053607
D
Fatty acid metabolism

20983
440
AI044900
K
Fatty acid metabolism

13004
1154
NM_053623
J, L
Fatty acid metabolism

13005
1154
NM_053623
C
Fatty acid metabolism

16150
953
NM_017340
G
Fatty acid metabolism

1977
870
NM_012930
L
Fatty acid metabolism, Glycerolipid metabolism, Mitochondrial





Carnitine Palmitoyltransferase (CPT) System

15411
1078
NM_031559
B, L
Fatty acid metabolism, Glycerolipid metabolism, Mitochondrial





Carnitine Palmitoyltransferase (CPT) System, Reversal of Insulin





Resistance by Leptin

21078
902
NM_016986
G
Fatty acid metabolism, Propanoate metabolism, Valine, leucine





and isoleucine degradation, beta-Alanine metabolism

20711
905
NM_016999
L
Fatty acid metabolism, Tryptophan metabolism

20713
905
NM_016999
J, L
Fatty acid metabolism, Tryptophan metabolism

20714
905
NM_016999
J, L
Fatty acid metabolism, Tryptophan metabolism

20715
905
NM_016999
L
Fatty acid metabolism, Tryptophan metabolism

67
1085
NM_031605
B
Fatty acid metabolism, Tryptophan metabolism

20716
984
NM_019623
G
Fatty acid metabolism, Tryptophan metabolism

4011
1076
NM_031543
J
Fatty acid metabolism, Tryptophan metabolism

4012
1076
NM_031543
J
Fatty acid metabolism, Tryptophan metabolism

19252
1145
NM_053576
H
Flavonoids, stilbene and lignin biosynthesis, Methane metabolism,





Phenylalanine metabolism

19254
1145
NM_053576
H
Flavonoids, stilbene and lignin biosynthesis, Methane metabolism,





Phenylalanine metabolism

21400
811
M36410
C, F
Folate biosynthesis

14996
883
NM_013059
GENERAL, D
Folate biosynthesis, Glycerolipid metabolism

1549
1009
NM_022508
G
Folate biosynthesis, Glyoxylate and dicarboxylate metabolism,





One carbon pool by folate

1527
934
NM_017220
B
Folate biosynthesis, Nicotinate and nicotinamide metabolism,





Purine metabolism, Pyrimidine metabolism

19936
1071
NM_031357
D
Folate biosynthesis, Pyrimidine metabolism, Taurine and





hypotaurine metabolism

20876
910
NM_017050
J
Free Radical Induced Apoptosis

6405
801
L38615
G
Free Radical Induced Apoptosis, Glutamate metabolism,





Glutathione metabolism

21975
923
NM_017154
B, L
Free Radical Induced Apoptosis, Purine metabolism

1877
911
NM_017052
A, D, E
Fructose and mannose metabolism

16726
1112
NM_031855
GENERAL, E, G,
Fructose and mannose metabolism




H, I

1340
1098
NM_031715
B
Fructose and mannose metabolism, Galactose metabolism,





Glycolysis/Gluconeogenesis, Pentose phosphate pathway

25377
800
L25387
D
Fructose and mannose metabolism, Galactose metabolism,





Glycolysis/Gluconeogenesis, Pentose phosphate pathway

19712
994
NM_021745
K
FXR and LXR Regulation of Cholesterol Metabolism

1214
1102
NM_031741
GENERAL, K
FXR and LXR Regulation of Cholesterol Metabolism

989
976
NM_019318
D, F
GATA3 participate in activating the Th2 cytokine genes





expression

14003
948
NM_017305
B, J
Glutamate metabolism, Glutathione metabolism

1247
792
J05181
J
Glutamate metabolism, Glutathione metabolism

18990
1072
NM_031509
H
Glutathione metabolism

20817
398
AI012589
GENERAL
Glutathione metabolism

20818
1233
X02904
GENERAL
Glutathione metabolism

21012
788
J02592
B
Glutathione metabolism

21014
791
J03914
B, L
Glutathione metabolism

15017
790
J03752
B
Glutathione metabolism

1399
907
NM_017006
GENERAL, H, I
Glutathione metabolism, Pentose phosphate pathway

3512
927
NM_017177
F
Glycerolipid metabolism

755
890
NM_013126
GENERAL
Glycerolipid metabolism, Phosphatidylinositol signaling system

1535
331
AB000778
F
Glycerolipid metabolism, Phospholipid degradation, Rac 1 cell





motility signaling pathway, Ras Signaling Pathway

21038
1042
NM_024484
H
Glycine, serine and threonine metabolism

21039
1042
NM_024484
H
Glycine, serine and threonine metabolism

1551
915
NM_017084
G
Glycine, serine and threonine metabolism

21585
1087
NM_031620
D
Glycine, serine and threonine metabolism

21586
1087
NM_031620
D
Glycine, serine and threonine metabolism

21587
1087
NM_031620
D
Glycine, serine and threonine metabolism

574
985
NM_019905
GENERAL, E, G, K
Glyoxylate and dicarboxylate metabolism

573
692
AI232087
J
Glyoxylate and dicarboxylate metabolism

22537
175
AA892799
GENERAL, A, D
Glyoxylate and dicarboxylate metabolism, Pyruvate metabolism

22538
175
AA892799
GENERAL, D
Glyoxylate and dicarboxylate metabolism, Pyruvate metabolism

22539
175
AA892799
GENERAL
Glyoxylate and dicarboxylate metabolism, Pyruvate metabolism

22540
221
AA924630
E
Glyoxylate and dicarboxylate metabolism, Pyruvate metabolism

3608
1049
NM_031044
GENERAL, J
Histidine metabolism

3610
1049
NM_031044
GENERAL, G, I, J
Histidine metabolism

3609
1203
S82579
F
Histidine metabolism

1698
906
NM_017000
GENERAL, B, H, I
Hypoxia and p53 in the Cardiovascular system, Sterol





biosynthesis

21239
1029
NM_024125
GENERAL, H, I
IL 6 signaling pathway, il6, interact6-1

4392
918
NM_017101
H
IL-2 Receptor B Protein Interaction Pathway

17234
507
AI102741
J
Inhibition of Matrix Metalloproteinases, p53 Signaling Pathway

10087
589
AI171803
GENERAL
Inositol metabolism, Propanoate metabolism, Valine, leucine and





isoleucine degradation

17269
1051
NM_031057
GENERAL
Inositol metabolism, Propanoate metabolism, Valine, leucine and





isoleucine degradation

20449
1074
NM_031530
GENERAL
Msp/Ron Receptor Signaling Pathway, Pertussis toxin-insensitive





CCR5 Signaling in Macrophage

6782
606
AI176170
B
mTOR Signaling Pathway

15295
887
NM_013102
GENERAL, H, I
mTOR Signaling Pathway

15296
887
NM_013102
H, I
mTOR Signaling Pathway

15297
887
NM_013102
K
mTOR Signaling Pathway

16625
324
AA998062
D
N-Glycans biosynthesis

21575
1093
NM_031698
J
N-Glycans biosynthesis

11653
62
AA848689
A, F
Nitrogen metabolism

18597
1067
NM_031325
B, H
Nucleotide sugars metabolism, Pentose and glucuronate





interconversions, Starch and sucrose metabolism

12606
1016
NM_022547
E, K
One carbon pool by folate

15050
520
AI103911
I
Oxidative phosphorylation

3099
664
AI229680
E
Oxidative phosphorylation, Ubiquinone biosynthesis

15653
1236
X14210
G
Oxidative phosphorylation, Ubiquinone biosynthesis

21302
404
AI013297
J
Oxidative phosphorylation, Ubiquinone biosynthesis

11454
1004
NM_022381
GENERAL
p53 Signaling Pathway

11455
1004
NM_022381
GENERAL
p53 Signaling Pathway

811
1095
NM_031705
GENERAL, I
Pantothenate and CoA biosynthesis, Pyrimidine metabolism, beta-





Alanine metabolism

812
1095
NM_031705
GENERAL, I
Pantothenate and CoA biosynthesis, Pyrimidine metabolism, beta-





Alanine metabolism

1508
1163
NM_053845
G
Pantothenate and CoA biosynthesis, Pyrimidine metabolism, beta-





Alanine metabolism

24643
1006
NM_022400
K
Pantothenate and CoA biosynthesis, Valine, leucine and





isoleucine biosynthesis, Valine, leucine and isoleucine





degradation

16039
1107
NM_031811
H
Pentose phosphate pathway

24582
939
NM_017243
D
Pentose phosphate pathway, Purine metabolism

1847
834
NM_012634
B
Pentose phosphate pathway, Purine metabolism

6055
831
NM_012619
GENERAL, D
Phenylalanine, tyrosine and tryptophan biosynthesis

14978
622
AI177386
F
Phosphatidylinositol signaling system

1844
835
NM_012637
J
Phosphatidylinositol signaling system

245
952
NM_017336
J
Phosphatidylinositol signaling system

247
952
NM_017336
J
Phosphatidylinositol signaling system

18095
624
AI177482
D
Phosphatidylinositol signaling system

23868
825
NM_012551
GENERAL, L
Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP





kinase pathway

23869
825
NM_012551
L
Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP





kinase pathway

23872
825
NM_012551
GENERAL
Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP





kinase pathway

18564
865
NM_012899
GENERAL
Porphyrin and chlorophyll metabolism

14138
94
AA859700
GENERAL
Porphyrin and chlorophyll metabolism

16521
379
AI010470
B, J, L
Porphyrin and chlorophyll metabolism

16520
823
NM_012532
GENERAL, B, C, L
Porphyrin and chlorophyll metabolism

1447
944
NM_017281
D
Proteasome

3987
943
NM_017280
GENERAL
Proteasome

3254
945
NM_017282
L
Proteasome

25253
1173
NM_057099
H
Proteasome

15535
946
NM_017283
L
Proteasome

15538
946
NM_017283
L
Proteasome

16708
864
NM_012895
GENERAL
Purine metabolism

1246
847
NM_012770
GENERAL, J
Purine metabolism

8888
916
NM_017090
B
Purine metabolism

14184
1106
NM_031776
GENERAL
Purine metabolism

14185
1106
NM_031776
GENERAL
Purine metabolism

17332
177
AA892829
J
Purine metabolism, Selenoamino acid metabolism, Sulfur





metabolism

20896
1148
NM_053592
A, F
Pyrimidine metabolism

2059
565
AI146005
A, H
Pyrimidine metabolism

12921
546
AI112636
GENERAL, B, L
Pyrimidine metabolism

24234
1086
NM_031614
GENERAL, A, I
Pyrimidine metabolism

24235
1086
NM_031614
GENERAL, H, I
Pyrimidine metabolism

1409
1124
NM_033349
GENERAL, A, C,
Pyruvate metabolism




E, F

18713
987
NM_020075
L
Regulation of eIF2

18716
987
NM_020075
F
Regulation of eIF2

1929
1045
NM_030872
A, C, D, E
Regulation of eIF4e and p70 S6 Kinase

24649
903
NM_016988
C, K
Riboflavin metabolism

17104
924
NM_017160
GENERAL, G
Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway,





mTOR Signaling Pathway

18354
1246
X59859
J
Small Leucine-rich Proteoglycan (SLRP) molecules

18352
1260
Z12298
L
Small Leucine-rich Proteoglycan (SLRP) molecules

15393
581
AI170663
J
SREBP and controls lipid synthesis

16681
920
NM_017136
B, L
Sterol biosynthesis, Terpenoid biosynthesis

15069
1111
NM_031840
H
Sterol biosynthesis, Terpenoid biosynthesis

23961
929
NM_017181
GENERAL, E, G, I
Styrene degradation, Tyrosine metabolism

14970
1059
NM_031127
GENERAL, B, H,
Sulfur metabolism




I, K

4749
1110
NM_031834
L
Sulfur metabolism

19824
995
NM_021750
G, K
Taurine and hypotaurine metabolism

17541
858
NM_012844
GENERAL, A, B,
Tetrachloroethene degradation




H, I

15242
964
NM_019191
D
TGF beta signaling pathway, tgf-beta

20493
988
NM_020076
GENERAL
Tryptophan metabolism

20494
988
NM_020076
E
Tryptophan metabolism

794
1166
NM_053902
GENERAL, I
Tryptophan metabolism

21950
412
AI013861
G
Valine, leucine and isoleucine degradation

4449
827
NM_012592
B, G, K
Valine, leucine and isoleucine degradation

4450
827
NM_012592
E
Valine, leucine and isoleucine degradation

4451
827
NM_012592
GENERAL, F
Valine, leucine and isoleucine degradation

17284
789
J02827
G
Valine, leucine and isoleucine degradation




























































































































































































































































































































































































































































TABLE 3





HUMAN HOMOLOGUES



Atty. Docket No. GENE-077/26US

Doc. No. 44941








GLGC

GenBank Acc or
Human Homologous Gene



Identifier
Seq ID
RefSeq ID
Name
Human Homologous Cluster Title
Model Code










15409
1182
NM_057197
2,4-dienoyl CoA reductase 1,
2,4-dienoyl CoA reductase 1, mitochondrial
L




mitochondrial

22602
341
AF044574
2,4-dienoyl CoA reductase 2,
2,4-dienoyl CoA reductase 1, mitochondrial, 2,4-dienoyl CoA reductase 2, peroxisomal, 2-
GENERAL




peroxisomal, 2-4-dienoyl-
4-dienoyl-Coenzyme A reductase 2, peroxisomal, Mus musculus , Similar to hypothetical




Coenzyme A reductase 2,
protein MGC4172, clone MGC: 18716 IMAGE: 4219994, mRNA, complete cds, carbonyl




peroxisomal
reductase 2, peroxisomal trans 2-enoyl CoA reductase; putative short chain alcohol





dehydrogenase, peroxisomal trans-2-enoyl-CoA reductase

20493
988
NM_020076
3-hydroxyanthranilate 3,4-
3-hydroxyanthranilate 3,4-dioxygenase
GENERAL




dioxygenase

20494
988
NM_020076
3-hydroxyanthranilate 3,4-
3-hydroxyanthranilate 3,4-dioxygenase
E




dioxygenase

21585
1087
NM_031620
3-phosphoglycerate
3-phosphoglycerate dehydrogenase, EST, Moderately similar to SERA MOUSE D-3-
D




dehydrogenase,
PHOSPHOGLYCERATE DEHYDROGENASE [ M. musculus ], ESTs, Weakly similar to 3-




phosphoglycerate
phosphoglycerate dehydrogenase [ Rattus norvegicus ] [ R. norvegicus ], Mus musculus




dehydrogenase
adult male testis cDNA, RIKEN full-length enriched library, clone: 4930404C15:3-





phosphoglycerate dehydrogenase, full insert sequence, glyoxylate





reductase/hydroxypyruvate reductase, phosphoglycerate dehydrogenase

21586
1087
NM_031620
3-phosphoglycerate
3-phosphoglycerate dehydrogenase, EST, Moderately similar to SERA MOUSE D-3-
D




dehydrogenase,
PHOSPHOGLYCERATE DEHYDROGENASE [ M. musculus ], ESTs, Weakly similar to 3-




phosphoglycerate
phosphoglycerate dehydrogenase [ Rattus norvegicus ] [ R. norvegicus ], Mus musculus




dehydrogenase
adult male testis cDNA, RIKEN full-length enriched library, clone: 4930404C15:3-





phosphoglycerate dehydrogenase, full insert sequence, glyoxylate





reductase/hydroxypyruvate reductase, phosphoglycerate dehydrogenase

21587
1087
NM_031620
3-phosphoglycerate
3-phosphoglycerate dehydrogenase, EST, Moderately similar to SERA MOUSE D-3-
D




dehydrogenase,
PHOSPHOGLYCERATE DEHYDROGENASE [ M. musculus ], ESTs, Weakly similar to 3-




phosphoglycerate
phosphoglycerate dehydrogenase [ Rattus norvegicus ] [ R. norvegicus ], Mus musculus




dehydrogenase
adult male testis cDNA, RIKEN full-length enriched library, clone: 4930404C15:3-





phosphoglycerate dehydrogenase, full insert sequence, glyoxylate





reductase/hydroxypyruvate reductase, phosphoglycerate dehydrogenase

1527
934
NM_017220
6-pyruvoyl-tetrahydropterin
6-pyruvoyl-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, ESTs, Weakly
B




synthase, 6-
similar to JC1405 6-pyruvoyltetrahydropterin synthase [ H. sapiens ], ESTs, Weakly similar




pyruvoyltetrahydropterin
to PTPS RAT 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE PRECURSOR




synthase
[ R. norvegicus ]

19936
1071
NM_031357
6-pyruvoyl-tetrahydropterin
ceroid-lipofuscinosis, neuronal 2, ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-
D




synthase, 6-
Bielschowsky disease)




pyruvoyltetrahydropterin




synthase, lysosomal




membrane glycoprotein 1,




lysosomal-associated




membrane protein 1

21882
815
M83740
6-pyruvoyl-tetrahydropterin

GENERAL, D




synthase/dimerization cofactor




of hepatocyte nuclear factor 1




alpha (TCF1)

22626
1040
NM_024400
a disintegrin-like and
ESTs, Highly similar to ATS8_MOUSE ADAM-TS 8 PRECURSOR (A DISINTEGRIN
GENERAL, K




metalloprotease (reprolysin
AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8) (ADAMTS-8)




type) with thrombospondin
(ADAM-TS8) (METH-2) [ M. musculus ], ESTs, Weakly similar to ATS1_MOUSE ADAM-TS




type 1 motif, 1
1 PRECURSOR (A DISINTEGRIN AND METALLOPROTEINASE WITH





THROMBOSPONDIN MOTIFS 1) (ADAMTS-1) (ADAM-TS1) [ M. musculus ], ESTs,





Weakly similar to T47158 hypothetical protein DKFZp762C1110.1 [ H. sapiens ], Mus





musculus , Similar to a disintegrin and metalloproteinase with thrombospondin motifs 1





(ADAMTS-1), clone IMAGE: 3491991, mRNA, partial cds, Mus musculus , Similar to a





disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4,





clone MGC: 38401 IMAGE: 5345809, mRNA, complete cds, a disintegrin-like and





metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1 a disintegrin-like





and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8

2153
1227
U75404
A kinase (PRKA) anchor
A kinase (PRKA) anchor protein (gravin) 12, ESTs, Highly similar to gravin [ H. sapiens ]
GENERAL, L




protein (gravin) 12

23698
821
NM_012489
acetyl-Coenzyme A
Mus musculus , Similar to Acetyl-Co A acetyltransferase 1, mitochondrial, clone
D




acyltransferase (peroxisomal 3-
MGC: 39067 IMAGE: 5365469, mRNA, complete cds, acetyl-Coenzyme A acyltransferase




oxoacyl-Coenzyme A
(peroxisomal 3-oxoacyl-Coenzyme A thiolase), acetyl-Coenzyme A acyltransferase 1




thiolase), acetyl-Coenzyme A
(peroxisomal 3-oxoacyl-Coenzyme A thiolase)




acyltransferase 1 (peroxisomal




3-oxoacyl-Coenzyme A




thiolase)

23699
821
NM_012489
acetyl-Coenzyme A
Mus musculus , Similar to Acetyl-Co A acetyltransferase 1, mitochondrial, clone
D, E




acyltransferase (peroxisomal 3-
MGC: 39067 IMAGE: 5365469, mRNA, complete cds, acetyl-Coenzyme A acyltransferase




oxoacyl-Coenzyme A
(peroxisomal 3-oxoacyl-Coenzyme A thiolase), acetyl-Coenzyme A acyltransferase 1




thiolase), acetyl-Coenzyme A
(peroxisomal 3-oxoacyl-Coenzyme A thiolase)




acyltransferase 1 (peroxisomal




3-oxoacyl-Coenzyme A




thiolase)

21078
902
NM_016986
acetyl-Coenzyme A
ESTs, Highly similar to ACYL-COA DEHYDROGENASE, MEDIUM-CHAIN SPECIFIC
G




dehydrogenase, medium
PRECURSOR [ M. musculus ], acetyl-Coenzyme A dehydrogenase, medium chain, acyl-




chain, acyl-Coenzyme A
Coenzyme A dehydrogenase, C-4 to C-12 straight chain




dehydrogenase, C-4 to C-12




straight chain

24649
903
NM_016988
acid phosphatase 2, lysosomal
ESTs, Weakly similar to A33395 acid phosphatase (EC 3.1.3.2) precursor - rat
C, K





[ R. norvegicus ], acid phosphatase 2, lysosomal, acid phosphatase, testicular

19991
1169
NM_053961
aconitase 2, mitochondrial
aconitase 2, mitochondrial
K

21165
1047
NM_031005
actinin, alpha 1
ESTs, Weakly similar to alpha actinin 4 [ Mus musculus ] [ M. musculus ], RIKEN cDNA
K





3110023F10 gene, actinin alpha 2, actinin alpha 3, actinin, alpha 1, actinin, alpha 2,





actinin, alpha 3, alpha actinin 4

21166
1047
NM_031005
actinin, alpha 1
ESTs, Weakly similar to alpha actinin 4 [ Mus musculus ] [ M. musculus ], RIKEN cDNA
K





3110023F10 gene, actinin alpha 2, actinin alpha 3, actinin, alpha 1, actinin, alpha 2,





actinin, alpha 3, alpha actinin 4

24431
868
NM_012912
activating transcription factor 3
ESTs, Weakly similar to A39382 liver regeneration factor LRF1 - rat [ R. norvegicus ],
GENERAL, F





ESTs, Weakly similar to A54025 transcription factor ATF3 [ H. sapiens ], activating





transcription factor 3

13104
374
AI010224
adducin 3 (gamma)

D

16708
864
NM_012895
adenosine kinase
adenosine kinase, expressed sequence AI987814
GENERAL

22219
972
NM_019286
alcohol dehydrogenase 1,
ESTs, Weakly similar to ADHA MOUSE ALCOHOL DEHYDROGENASE A CHAIN
F




complex, alcohol
[ M. musculus ], alcohol dehydrogenase 1, complex, alcohol dehydrogenase 1A (class I),




dehydrogenase 1A (class I),
alpha polypeptide, alcohol dehydrogenase IB (class I), beta polypeptide




alpha polypeptide

23884
1099
NM_031731
aldehyde dehydrogenase 3
RIKEN cDNA 1700001N19 gene, RIKEN cDNA 1700055N04 gene, aldehyde
J




family, member A2, aldehyde
dehydrogenase 3 family, member A2, aldehyde dehydrogenase family 3, subfamily A2,




dehydrogenase family 3,
expressed sequence AI848594




subfamily A2

16884
517
AI103758
aldehyde dehydrogenase 9
Mus musculus , Similar to aldehyde dehydrogenase 4 family, member A1, clone
E




family, member A1, aldehyde
IMAGE: 5102023, mRNA, partial cds, RIKEN cDNA 1110038I05 gene, aldehyde




dehydrogenase 9, subfamily
dehydrogenase 4 family, member A1, aldehyde dehydrogenase 9 family, member A1,




A1
aldehyde dehydrogenase 9, Subfamily A1

16885
531
AI105188
aldehyde dehydrogenase 9
Mus musculus , Similar to aldehyde dehydrogenase 4 family, member A1, clone
K




family, member A1, aldehyde
IMAGE: 5102023, mRNA, partial cds, RIKEN cDNA 1110038I05 gene, aldehyde




dehydrogenase 9, subfamily
dehydrogenase 4 family, member A1, aldehyde dehydrogenase 9 family, member A1,




A1
aldehyde dehydrogenase 9, subfamily A1

16625
324
AA998062
Alg5, S. cerevisiae , homolog
Alg5, S. cerevisiae , homolog of
D




of

15032
852
NM_012816
alpha-methylacyl-CoA
alpha-methylacyl-CoA racemase, cDNA sequence AF397014, chromosome 7 open
GENERAL, A, H, I, K, L




racemase
reading frame 10

18564
865
NM_012899
aminolevulinate, delta-,
aminolevulinate, delta-, dehydratase
GENERAL




dehydratase

21038
1042
NM_024484
aminolevulinate, delta-,
aminolevulinate, delta-, synthase 1, aminolevulinic acid synthase 1, aminolevulinic acid
H




synthase 1, aminolevulinic
synthase 2, erythroid, serine palmitoyltransferase, long chain base subunit 1, serine




acid synthase 1
palmitoyltransferase long chain base subunit 2

21039
1042
NM_024484
aminolevulinate, delta-,
aminolevulinate, delta-, synthase 1, aminolevulinic acid synthase 1, aminolevulinic acid
H




synthase 1, aminolevulinic
synthase 2, erythroid, serine palmitoyltransferase, long chain base subunit 1, serine




acid synthase 1
palmitoyltransferase, long chain base subunit 2

2079
966
NM_019220
amino-terminal enhancer of
amino-terminal enhancer of split
F




split

7196
867
NM_012904
annexin A1
annexin A1
GENERAL, E, G, K

7197
867
NM_012904
annexin A1
annexin A1
GENERAL, G, K, L

574
985
NM_019905
annexin A2, hydroxyacid
EST, Moderately similar to 0806162C protein COI [ M. musculus ], EST, Moderately similar
GENERAL, E, G, K




oxidase (glycolate oxidase) 3,
to 810024C cytochrome oxidase I [ H. sapiens ], EST, Weakly similar to 0806162C protein




hydroxyacid oxidase 3
COI [ M. musculus ], ESTs, Highly similar to hydroxyacid oxidase 3 (medium-chain)




(medium-chain)
[ Rattus norvegicus ] [ R. norvegicus ], ESTs, Moderately similar to 0806162C protein COI





[ M. musculus ], ESTs, Moderately similar to 810024C cytochrome oxidase I [ H. sapiens ],





ESTs, Weakly similar to 0806162C protein COI [ M. musculus ], annexin A2, annexin A9,





hydroxyacid oxidase (glycolate oxidase) 3, hydroxyacid oxidase 1, liver

21391
1192
NM_130416
annexin A7
annexin A11, annexin A13, annexin A7
GENERAL, K

19252
1145
NM_053576
anti-oxidant protein 2 (non-
ESTs, Moderately similar to AOP2 MOUSE ANTIOXIDANT PROTEIN 2 [ M. musculus ],
H




selenium glutathione
ESTs, Moderately similar to AOP2_HUMAN ANTIOXIDANT PROTEIN 2 [ H. sapiens ], anti-




peroxidase, acidic calcium-
oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent




independent phospholipase
phospholipase A2), peroxiredoxin 5




A2), peroxiredoxin 5

19254
1145
NM_053576
anti-oxidant protein 2 (non-
ESTs, Moderately similar to AOP2 MOUSE ANTIOXIDANT PROTEIN 2 [ M. musculus ],
H




selenium glutathione
ESTs, Moderately similar to AOP2_HUMAN ANTIOXIDANT PROTEIN 2 [ H. sapiens ], anti-




peroxidase, acidic calcium-
oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent




independent phospholipase
phospholipase A2), peroxiredoxin 5




A2), peroxiredoxin 5

20801
1033
NM_024148
APEX nuclease
APEX nuclease (multifunctional DNA repair enzyme), Mus musculus ape2 mRNA for AP
GENERAL, H, I, J, L




(multifunctional DNA repair
endonuclease 2, complete cds, apurinic/apyrimidinic endonuclease




enzyme), apurinic/apyrimidinic




endonuclease

1509
962
NM_019157
aquaporin 7
EST, Moderately similar to AQP7_HUMAN AQUAPORIN 7 [ H. sapiens ], ESTs, Highly
A





similar to AQP7_HUMAN AQUAPORIN 7 [ H. sapiens ], aquaporin 7
A

20173
959
NM_019136
arginine vasopressin receptor
arginine vasopressin receptor 2, arginine vasopressin receptor 2 (nephrogenic diabetes
C




2, arginine vasopressin
insipidus)




receptor 2 (nephrogenic




diabetes insipidus)

20725
1149
NM_053602
ATP synthase, H+
ATP synthase, H+ transporting, mitochondrial F0 complex subunit F, ATP synthase, H+
A




transporting, mitochondrial F0
transporting, mitochondrial F0 complex, subunit F6




complex subunit F, ATP




synthase, H+ transporting,




mitochondrial F0 complex,




subunit F6

12349
947
NM_017290
ATPase, Ca++ transporting,

GENERAL




cardiac muscle, slow twitch 2

15701
1187
NM_080581
ATP-binding cassette, sub-
ATP-binding cassette, sub-family C (CFTR/MRP), member 1, ATP-binding cassette, sub-
A, I




family C (CFTR/MRP),
family C (CFTR/MRP), member 1a, ATP-binding cassette, sub-family C (CFTR/MRP),




member 3
member 3, Mus musculus multidrug resistance-associated protein 7B mRNA, complete





cds

989
976
NM_019318
avian musculoaponeurotic
EST, Moderately similar to MAF2 MOUSE TRANSCRIPTION FACTOR MAF2
D, F




fibrosarcoma (v-maf) AS42
[ M. musculus ], ESTs, Highly similar to MAF2 MOUSE TRANSCRIPTION FACTOR MAF2




oncogene homolog, solute
[ M. musculus ], ESTs, Weakly similar to MAF2 MOUSE TRANSCRIPTION FACTOR




carrier family 24
MAF2 [ M. musculus ], v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)




(sodium/potassium/calcium




exchanger), member 2, v-maf




musculoaponeurotic




fibrosarcoma oncogene




homolog (avian)

5565
1153
NM_053618
Bardet-Biedl syndrome 2,
Bardet-Biedl syndrome 2, ESTs, Weakly similar to Bardet-Biedl syndrome 2 (human)
GENERAL, C




Bardet-Biedl syndrome 2
[ Rattus norvegicus ] [ R. norvegicus ]




(human)

19
941
NM_017258
B-cell translocation gene 1,
B-cell translocation gene 1, anti-proliferative, Homo sapiens cDNA FLJ30547 fis, clone
GENERAL




anti-proliferative
BRAWH2001439, transducer of ERBB2, 1, transducer of ERBB2, 2, transducer of ErbB-





2.1

15299
942
NM_017259
B-cell translocation gene 2,
B-cell translocation gene 2, anti-proliferative, B-cell translocation gene 4, BTG family,
GENERAL, I, J




anti-proliferative, BTG family,
member 2, ESTs, Highly similar to BTG2_HUMAN BTG2 PROTEIN PRECURSOR




member 2
[ H. sapiens ]

15300
942
NM_017259
B-cell translocation gene 2,
B-cell translocation gene 2, anti-proliferative, B-cell translocation gene 4, BTG family,
GENERAL




anti-proliferative, BTG family,
member 2, ESTs, Highly similar to BTG2_HUMAN BTG2 PROTEIN PRECURSOR




member 2
[ H. sapiens ]

439
854
NM_012827
bone morphogenetic protein 4
bone morphogenetic protein 4, endometrial bleeding associated factor, growth
F





differentiation factor 2, growth differentiation factor 5

24643
1006
NM_022400
branched chain
Homo sapiens cDNA FLJ13847 fis, clone THYRO1000852, highly similar to Human
K




aminotransferase 2,
branched-chain amino acid aminotransferase (ECA40) mRNA, branched chain




mitochondrial
aminotransferase 2, mitochondrial

17284
789
J02827
branched chain keto acid

G




dehydrogenase E1, alpha




polypeptide (maple syrup urine




disease), branched chain




ketoacid dehydrogenase E1,




alpha polypeptide

433
869
NM_012916
brevican, chondroitin sulfate

C




proteoglycan BEHAB/brevican

18502
1118
NM_031984
calbindin 1, (28 kD), calbindin-
Mus musculus , Similar to secretagogin, clone MGC: 27615 IMAGE: 4504330, mRNA,
G, J




28K
complete cds, calbindin 1, (28 kD), calbindin-28K

18503
1118
NM_031984
calbindin 1, (28 kD), calbindin-
Mus musculus , Similar to secretagogin, clone MGC: 27615 IMAGE: 4504330, mRNA,
G




28K
complete cds, calbindin 1, (28 kD), calbindin-28K

25802
1113
NM_031969
calmodulin 1, calmodulin 1
RIKEN cDNA 2310068O22 gene, calmodulin 1, calmodulin 1 (phosphorylase kinase,
G, K




(phosphorylase kinase, delta)
delta), calmodulin 2, calmodulin 2 (phosphorylase kinase, delta), calmodulin 3, calmodulin





like 3, centrin 1, centrin, EF-hand protein, 1, expressed sequence AI327027, expressed





sequence AL024000, troponin C, fast skeletal

20809
951
NM_017326
calmodulin 2, calmodulin 2
RIKEN cDNA 2310068O22 gene, calmodulin 1, calmodulin 1 (phosphorylase kinase,
D




(phosphorylase kinase, delta)
delta), calmodulin 2, calmodulin 2 (phosphorylase kinase, delta), calmodulin 3, calmodulin





like 3, centrin 1, centrin, EF-hand protein, 1, expressed sequence AI327027, expressed





sequence AL024000, troponin C, fast skeletal

15035
855
NM_012836
carboxypeptidase D
carboxypeptidase D, carboxypeptidase M
B

20555
1120
NM_031987
carnitine O-
carnitine O-octanoyltransferase
F




octanoyltransferase

15411
1078
NM_031559
carnitine palmitoyltransferase
ESTs, Weakly similar to CPT1 MOUSE CARNITINE O-PALMITOYLTRANSFERASE I,
B, L




1, liver, carnitine
MITOCHONDRIAL LIVER ISOFORM [ M. musculus ], carnitine palmitoyltransferase 1,




palmitoyltransferase I, liver
liver, carnitine palmitoyltransferase I, liver

1977
870
NM_012930
carnitine palmitoyltransferase
carnitine palmitoyltransferase 2, carnitine palmitoyltransferase II
L




2, carnitine




palmitoyltransferase II

16116
1105
NM_031775
caspase 6, caspase 6,
caspase 6, caspase 6, apoptosis-related cysteine protease
F




apoptosis-related cysteine




protease

3430
897
NM_013156
cathepsin L
ESTs, Weakly similar to CATL MOUSE CATHEPSIN L PRECURSOR [ M. musculus ],
GENERAL, G, I





RIKEN cDNA 4930486L24 gene, cathepsin L, expressed sequence AA408230

21239
1029
NM_024125
CCAAT/enhancer binding
CCAAT/enhancer binding protein (C/EBP), beta
GENERAL, H, I




protein (C/EBP), beta

21683
896
NM_013154
CCAAT/enhancer binding
CCAAT/enhancer binding protein (C/EBP), delta
GENERAL, C, I, L




protein (C/EBP), delta

20828
846
NM_012752
CD24 antigen (small cell lung

GENERAL, E, K




carcinoma cluster 4 antigen),




CD24a antigen

20829
846
NM_012752
CD24 antigen (small cell lung

GENERAL, D




carcinoma cluster 4 antigen),




CD24a antigen

20830
846
NM_012752
CD24 antigen (small cell lung

GENERAL




carcinoma cluster 4 antigen),




CD24a antigen

16521
379
AI010470
ceruloplasmin, ceruloplasmin
DNA segment, Chr 3, ERATO Doi 555, expressed, EST, Highly similar to FA8_HUMAN
B, J, L




(ferroxidase)
COAGULATION FACTOR VIII PRECURSOR [ H. sapiens ], ESTs, Weakly similar to





CERU MOUSE CERULOPLASMIN PRECURSOR [ M. musculus ], ESTs, Weakly similar to





CERU_RAT CERULOPLASMIN PRECURSOR (FERROXIDASE) [ R. norvegicus ], ESTs,





Weakly similar to KUHU ferroxidase [ H. sapiens ], ceruloplasmin, ceruloplasmin





(ferroxidase), coagulation factor VIII, procoagulant component (hemophilia A)

16520
823
NM_012532
ceruloplasmin, ceruloplasmin
DNA segment, Chr 3, ERATO Doi 555, expressed, EST, Highly similar to FA8_HUMAN
GENERAL, B, C, L




(ferroxidase)
COAGULATION FACTOR VIII PRECURSOR [ H. sapiens ], ESTs, Weakly similar to





CERU MOUSE CERULOPLASMIN PRECURSOR [ M. musculus ], ESTs, Weakly similar to





CERU_RAT CERULOPLASMIN PRECURSOR (FERROXIDASE) [ R. norvegicus ], ESTs,





Weakly similar to KUHU ferroxidase [ H. sapiens ], ceruloplasmin, ceruloplasmin





(ferroxidase), coagulation factor VIII, procoagulant component (hemophilia A)

3512
927
NM_017177
choline kinase-like
EST, Weakly similar to KICE MOUSE CHOLINE/ETHANOLAMINE KINASE
F





[ M. musculus ], ESTs, Weakly similar to KICE_RAT Choline/ethanolamine kinase





[Includes: Choline kinase (CK); Ethanolamine kinase (EK)] [ R. norvegicus ], Homo





sapiens , Similar to hypothetical protein FLJ10761, clone MGC: 19512 IMAGE: 4329734,





mRNA, complete cds, RIKEN cDNA 4930555L11 gene, choline kinase-like, ethanolamine





kinase, expressed sequence AI197444

20404
1094
NM_031700
claudin 3
claudin 3
L

20405
1094
NM_031700
claudin 3
claudin 3
B

16350
777
AJ011811
claudin 7
ESTs, Weakly similar to CLD7_RAT CLAUDIN-7 [ R. norvegicus ], Mus musculus claudin
G





19 mRNA, complete cds, claudin 10, claudin 15, claudin 7

16351
777
AJ011811
claudin 7
ESTs, Weakly similar to CLD7_RAT CLAUDIN-7 [ R. norvegicus ], Mus musculus claudin
G





19 mRNA, complete cds, claudin 10, claudin 15, claudin 7

15364
921
NM_017147
cofilin 1 (non-muscle), cofilin
cofilin 1 (non-muscle), cofilin 1, non-muscle, cofilin 2 (muscle), cofilin 2, muscle,
J




1, non-muscle
expressed sequence AW987265

16610
781
D28557
cold shock domain protein A
Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library,
E, L





clone: 2610205I19:Y box protein 1, full insert sequence, Mus musculus Y-box binding





protein (oxyR) mRNA, partial cds, cold shock domain protein A

21443
968
NM_019262
complement component 1, q

GENERAL, L




subcomponent, beta




polypeptide

15851
1219
U42719
complement component 4
complement component 4 (within H-2S), complement component 4A
GENERAL




(within H-2S), complement




component 4B

954
1121
NM_032061
contactin associated protein 1
EST, Weakly similar to T14158 neurexin IV - mouse [ M. musculus ], EST, Weakly similar
B





to T31083 paranodin - rat [ R. norvegicus ], ESTs, Weakly similar to T14158 neurexin IV -





mouse [ M. musculus ], ESTs, Weakly similar to T31083 paranodin - rat [ R. norvegicus ],





contactin associated protein 1

1727
1088
NM_031642
core promoter element binding
DNA segment, Chr 12, ERATO Doi 427, expressed, EST, Moderately similar to core
GENERAL




protein
promoter element binding protein [ Rattus norvegicus ] [ R. norvegicus ], ESTs, Weakly





similar to core promoter element binding protein [ Rattus norvegicus ] [ R. norvegicus ],





Kruppel-like factor 7 (ubiquitous), core promoter element binding protein

13723
871
NM_012935
crystallin, alpha B
ESTs, Moderately similar to T46637 transcription factor 1, neural - rat [ R. norvegicus ],
K





ESTs, Weakly similar to A35804 nucleolin [ H. sapiens ], ESTs, Weakly similar to alpha-





crystallin chain B [ M. musculus ], Homo sapiens mRNA; cDNA DKFZp434E0922 (from





clone DKFZp434E0922), Mus musculus 10, 11 days embryo whole body cDNA, RIKEN





full-length enriched library, clone: 2810003I18:myelin transcription factor 1-like, full insert





sequence, crystallin, alpha B, myelin transcription factor 1-like, nucleolin

3572
325
AA998516
cyclin A2
Cyclin B1, DNA segment, Chr 4, ERATO Doi 639, expressed, EST, Moderately similar to
E





G2/MITOTIC-SPECIFIC CYCLIN B2 [ M. musculus ], ESTs, Weakly similar to CGB1_RAT





G2/mitotic-specific cyclin B1 [ R. norvegicus ], cyclin A2, cyclin B1, related sequence 1

11434
778
D14014
cyclin D1, cyclin D1 (PRAD1:
EST, Moderately similar to JC2342 cyclin D1 - rat [ R. norvegicus ], cyclin D1, cyclin D1
B




parathyroid adenomatosis 1)
(PRAD1: parathyroid adenomatosis 1)

24232
1252
X75207
cyclin D1, cyclin D1 (PRAD1:
EST, Moderately similar to JC2342 cyclin D1 - rat [ R. norvegicus ], cyclin D1, cyclin D1
B




parathyroid adenomatosis 1)
(PRAD1: parathyroid adenomatosis 1)

291
822
NM_012522
cystathionine beta-synthase,
cystathionine-beta-synthase, expressed sequence AU040765, serine dehydratase, serine
GENERAL, F




cystathionine-beta-synthase
racemase

15028
1129
NM_052809
cysteine dioxygenase 1,
cysteine dioxygenase 1, cytosolic, cysteine dioxygenase, type I
F




cytosolic, cysteine




dioxygenase, type I

11137
856
NM_012839
cytochrome c, cytochrome c,

J




somatic

4011
1076
NM_031543
cytochrome P450, 2e1,

J




ethanol inducible, cytochrome




P450, subfamily IIE (ethanol-




inducible)

4012
1076
NM_031543
cytochrome P450, 2e1,

J




ethanol inducible, cytochrome




P450, subfamily IIE (ethanol-




inducible)

20711
905
NM_016999
cytochrome P450, subfamily
EST, Moderately similar to I65981 fatty acid omega-hydroxylase [ H. sapiens ], Mus
L




IV B, polypeptide 1,
musculus , Similar to cytochrome P450, 4a10, clone MGC: 18880 IMAGE: 4237837,




cytochrome P450, subfamily
mRNA, complete cds, Mus musculus , Similar to cytochrome P450, 4a10, clone




IVB, polypeptide 1
MGC: 25972 IMAGE: 4240359, mRNA, complete cds, RIKEN cDNA A230105L22 gene,





cytochrome P450, 4a10, cytochrome P450, subfamily IVA, polypeptide 11, expressed





sequence AI314743

20713
905
NM_016999
cytochrome P450, subfamily
EST, Moderately similar to I65981 fatty acid omega-hydroxylase [ H. sapiens ], Mus
J, L




IV B, polypeptide 1,
musculus , Similar to cytochrome P450, 4a10, clone MGC: 18880 IMAGE: 4237837,




cytochrome P450, subfamily
mRNA, complete cds, Mus musculus , Similar to cytochrome P450, 4a10, clone




IVB, polypeptide 1
MGC: 25972 IMAGE: 4240359, mRNA, complete cds, RIKEN cDNA A230105L22 gene,





cytochrome P450, 4a10, cytochrome P450, subfamily IVA, polypeptide 11, expressed





sequence AI314743

20714
905
NM_016999
cytochrome P450, subfamily
EST, Moderately similar to I65981 fatty acid omega-hydroxylase [ H. sapiens ], Mus
J, L




IV B, polypeptide 1,
musculus , Similar to cytochrome P450, 4a10, clone MGC: 18880 IMAGE: 4237837,




cytochrome P450, subfamily
mRNA, complete cds, Mus musculus , Similar to cytochrome P450, 4a10, clone




IVB, polypeptide 1
MGC: 25972 IMAGE: 4240359, mRNA, complete cds, RIKEN cDNA A230105L22 gene,





cytochrome P450, 4a10, cytochrome P450, subfamily IVA, polypeptide 11, expressed





sequence AI314743

20715
905
NM_016999
cytochrome P450, subfamily
EST, Moderately similar to I65981 fatty acid omega-hydroxylase [ H. sapiens ], Mus
L




IV B, polypeptide 1,
musculus , Similar to cytochrome P450, 4a10, clone MGC: 18880 IMAGE: 4237837,




cytochrome P450, subfamily
mRNA, complete cds, Mus musculus , Similar to cytochrome P450, 4a10, clone




IVB, polypeptide 1
MGC: 25972 IMAGE: 4240359, mRNA, complete cds, RIKEN cDNA A230105L22 gene,





cytochrome P450, 4a10, cytochrome P450, subfamily IVA, polypeptide 11, expressed





sequence AI314743

1858
1064
NM_031315
cytosolic acyl-CoA
EST, Moderately similar to PTE2_HUMAN PEROXISOMAL ACYL-COENZYME A
B, L




thioesterase 1, mitochondrial
THIOESTER HYDROLASE 2 (PEROXISOMAL LONG-CHAIN ACYL-COA




acyl-CoA thioesterase 1,
THIOESTERASE 2) (ZAP128) [ H. sapiens ], ESTs, Weakly similar to MTE1_RAT Acyl




peroxisomal long-chain acyl-
coenzyme A thioester hydrolase, mitochondrial precursor (Very-long-chain acyl-CoA




coA thioesterase
thioesterase) (MTE-I) [ R. norvegicus ], ESTs, Weakly similar to PTE2_HUMAN





PEROXISOMAL ACYL-COENZYME A THIOESTER HYDROLASE 2 (PEROXISOMAL





LONG-CHAIN ACYL-COA THIOESTERASE 2) (ZAP128) [ H. sapiens ], Homo sapiens





cDNA FLJ31235 fis, clone KIDNE2004681, moderately similar to Mus musculus





peroxisomal long chain acyl-CoAthioesterase lb (Pte1b) gene, Mus musculus , Similar to





bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase), clone





MGC: 19156 IMAGE: 4220620, mRNA, complete cds, cytosolic acyl-CoA thioesterase 1,





mitochondrial acyl-CoA thioesterase 1, peroxisomal long-chain acyl-coA thioesterase

1857
1064
NM_031315
cytosolic acyl-CoA
EST, Moderately similar to PTE2_HUMAN PEROXISOMAL ACYL-COENZYME A
L




thioesterase 1, peroxisomal
THIOESTER HYDROLASE 2 (PEROXISOMAL LONG-CHAIN ACYL-COA




long-chain acyl-coA
THIOESTERASE 2) (ZAP128) [ H. sapiens ], ESTs, Weakly similar to PTE2_HUMAN




thioesterase
PEROXISOMAL ACYL-COENZYME A THIOESTER HYDROLASE 2 (PEROXISOMAL





LONG-CHAIN ACYL-COA THIOESTERASE 2) (ZAP128) [ H. sapiens ], Homo sapiens





cDNA FLJ31235 fis, clone KIDNE2004681, moderately similar to Mus musculus





peroxisomal long chain acyl-CoA thioesterase lb (Pte1b) gene, cytosolic acyl-CoA





thioesterase 1, peroxisomal long-chain acyl-coA thioesterase

17226
1031
NM_024131
D-dopachrome tautomerase
D-dopachrome tautomerase, EST, Moderately similar to DOPD_HUMAN D-
C, E





DOPACHROME TAUTOMERASE [ H. sapiens ]

17227
1031
NM_024131
D-dopachrome tautomerase
D-dopachrome tautomerase, EST, Moderately similar to DOPD_HUMAN D-
E





DOPACHROME TAUTOMERASE [ H. sapiens ]

18354
1246
X59859
decorin
RIKEN cDNA 5530600M07 gene, decorin, expressed sequence C85409, extracellular
J





matrix protein 2, female organ and adipocyte specific

18352
1260
Z12298
decorin
RIKEN cDNA 5530600M07 gene, decorin, expressed sequence C85409, extracellular
L





matrix protein 2, female organ and adipocyte specific

19678
992
NM_021653
deiodinase, iodothyronine,
ESTs, Moderately similar to IOD1_RAT TYPE I IODOTHYRONINE DEIODINASE (TYPE-
GENERAL




type I
I 5′DEIODINASE) (DIOI) (TYPE 1 DI) (5DI) [ R. norvegicus ], deiodinase, iodothyronine,





type I

19679
992
NM_021653
deiodinase, odothyronine,
ESTs, Moderately similar to IOD1_RAT TYPE I IODOTHYRONINE DEIODINASE (TYPE-
GENERAL, A, D, G, I




type I
I 5′DEIODINASE) (DIOI) (TYPE 1 DI) (5DI) [ R. norvegicus ], deiodinase, iodothyronine,





type I

755
890
NM_013126
diacylglycerol kinase, gamma
ESTs, Highly similar to KDGA MOUSE DIACYLGLYCEROL KINASE, ALPHA
GENERAL




(90 kD), diacylglycerol kinase,
[ M. musculus ], ESTs, Moderately similar to KDGG_HUMAN DIACYLGLYCEROL




gamma 3
KINASE, GAMMA [ H. sapiens ], ESTs, Weakly similar to KDGA MOUSE





DIACYLGLYCEROL KINASE, ALPHA [ M. musculus ], diacylglycerol kinase, alpha (80 kDA),





diacylglycerol kinase, gamma (90 kD), diacylglycerol kinase, gamma 3

811
1095
NM_031705
dihydropyrimidinase
ESTs, Weakly similar to DPY1 MOUSE DIHYDROPYRIMIDINASE RELATED PROTEIN-
GENERAL, I





1 [ M. musculus ], dihydropyrimidinase

812
1095
NM_031705
dihydropyrimidinase
ESTs, Weakly similar to DPY1 MOUSE DIHYDROPYRIMIDINASE RELATED PROTEIN-
GENERAL, I





1 [ M. musculus ], dihydropyrimidinase

7784
848
NM_012789
dipeptidylpeptidase 4,
ESTs, Weakly similar to DPP4 MOUSE DIPEPTIDYL PEPTIDASE IV [ M. musculus ],
GENERAL, I




dipeptidylpeptidase IV (CD26,
ESTs, Weakly similar to DPP4_RAT Dipeptidyl peptidase IV (DPP IV) (GP110




adenosine deaminase
glycoprotein) (Bile canaliculus domain-specific membrane glycoprotein) [ R. norvegicus ],




complexing protein 2)
dipeptidylpeptidase 4, dipeptidylpeptidase 8, fibroblast activation protein, fibroblast





activation protein, alpha

1430
816
M84648
dopa decarboxylase, dopa
EST, Highly similar to DDC_RAT Aromatic-L-amino-acid decarboxylase (AADC) (DOPA
GENERAL




decarboxylase (aromatic L-
decarboxylase) (DDC) [ R. norvegicus ], EST, Moderately similar to DDC_RAT Aromatic-L-




amino acid decarboxylase)
amino-acid decarboxylase (AADC) (DOPA decarboxylase) (DDC) [ R. norvegicus ], Mus





musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library,





clone: 2610109O21:dopa decarboxylase, full insert sequence, dopa decarboxylase, dopa





decarboxylase (aromatic L-amino acid decarboxylase)

1431
824
NM_012545
dopa decarboxylase, dopa
EST, Highly similar to DDC_RAT Aromatic-L-amino-acid decarboxylase (AADC) (DOPA
D




decarboxylase (aromatic L-
decarboxylase) (DDC) [ R. norvegicus ], EST, Moderately similar to DDC_RAT Aromatic-L-




amino acid decarboxylase)
amino-acid decarboxylase (AADC) (DOPA decarboxylase) (DDC) [ R. norvegicus ], Mus





musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library,





clone: 2610109O21:dopa decarboxylase, full insert sequence, dopa decarboxylase, dopa





decarhoxylase (aromatic L-amino acid decarboxylase

17473
1132
NM_053319
dynein, cytoplasmic, light
ESTs, Moderately similar to protein inhibitor of nitric oxide synthase [ M. musculus ],
GENERAL, K




chain 1, dynein, cytoplasmic,
dynein, axon, light chain 4, dynein, axonemal, light polypeptide 4, dynein, cytoplasmic,




light polypeptide
light chain 1, dynein, cytoplasmic, light polypeptide

23868
825
NM_012551
early growth response 1
early growth response 1, expressed sequence AI835008
GENERAL, L

23869
825
NM_012551
early growth response 1
early growth response 1, expressed sequence AI835008
L

23872
825
NM_012551
early growth response 1
early growth response 1, expressed sequence AI835008
GENERAL

16227
960
NM_019137
early growth response 4
RIKEN cDNA 4930563M09 gene, early growth response 4
F

20865
795
L00117
elastase 1, pancreatic
elastase 1, pancreatic
GENERAL

20925
1019
NM_022594
enoyl Coenzyme A hydratase
EST, Moderately similar to Peroxisomal enoyl hydratase-like protein; enoyl hydratase-
L




1, peroxisomal, enoyl
like protein, peroxisomal [ Rattus norvegicus ] [ R. norvegicus ], enoyl Coenzyme A




coenzyme A hydratase 1,
hydratase 1, peroxisomal, enoyl coenzyme A hydratase 1, peroxisomal




peroxisomal

21562
1185
NM_078623
enoyl Coenzyme A hydratase,
AU RNA binding protein/enoyl-Coenzyme A hydratase, AU RNA binding protein/enoyl-
A




short chain, 1, mitochondrial
coenzyme A hydratase, Mus musculus , Similar to 3-hydroxyisobutyryl-Coenzyme A





hydrolase, clone MGC: 31364 IMAGE: 4238681, mRNA, complete cds, RIKEN cDNA





1300017C12 gene, RIKEN cDNA 1810022C23 gene, RIKEN cDNA 2310005D12 gene,





enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, hypothetical protein





FLJ10948

2465
812
M59814
Eph receptor B2, EphB2
EST, Highly similar to putative protein-tyrosine kinase [ Homo sapiens ] [ H. sapiens ], Eph
G, K





receptor B1, Eph receptor B2, Eph receptor B3, EphB1, expressed sequence AW456895,





expressed sequence AW488255

17907
708
AI233224
epidermal growth factor
EST, Moderately similar to EGFR_HUMAN EPIDERMAL GROWTH FACTOR
GENERAL




receptor, epidermal growth
RECEPTOR PRECURSOR [ H. sapiens ], Homo sapiens truncated epidermal growth factor




factor receptor (erythroblastic
receptor (EGFR) mRNA, partial cds; alternatively spliced, epidermal growth factor




leukemia viral (v-erb-b)
receptor




oncogene homolog, avian)

20884
857
NM_012842
epidermal growth factor,
Homo sapiens mRNA; cDNA DKFZp667O055 (from clone DKFZp667O055), epidermal
G, K




epidermal growth factor (beta-
growth factor, epidermal growth factor (beta-urogastrone), nidogen 2




urogastrone)

20885
857
NM_012842
epidermal growth factor,
Homo sapiens mRNA; cDNA DKFZp667O055 (from clone DKFZp667O055), epidermal
G, K




epidermal growth factor (beta-
growth factor, epidermal growth factor (beta-urogastrone), nidogen 2




urogastrone)

17541
858
NM_012844
epoxide hydrolase 1,
epoxide hydrolase 1, microsomal, epoxide hydrolase 1, microsomal (xenobiotic)
GENERAL, A, B, H, I




microsomal, epoxide




hydrolase 1, microsomal




(xenobiotic)

8188
1167
NM_053927
erythrocyte membrane protein
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived),
GENERAL




band 4.1-like 3, erythrocyte
Homo sapiens , Similar to erythrocyte membrane protein band 4.1-like 3, clone




protein band 4.1-like 3
MGC: 12343 IMAGE: 4044866, mRNA, complete cds, KIAA0793 gene product,





erythrocyte membrane protein band 4.1-like 3, erythrocyte protein band 4.1-like 3,





erythrocyte protein band 4.1-like 4b, myosin regulatory light chain interacting protein,





protein tyrosine phosphatase non-receptor type 3

744
983
NM_019622
espin
ankyrin 2, neuronal, espin, expressed sequence AW549277, feminization 1 homolog a
GENERAL





( C. elegans ), hypothetical protein LOC51239, synuclein, alpha interacting protein





(synphilin)

18713
987
NM_020075
eukaryotic translation initiation
DNA segment, Chr 1, ERATO Doi 692, expressed, ESTs, Highly similar to EUKARYOTIC
L




factor 5
TRANSLATION INITIATION FACTOR 5 [ R. norvegicus ], KIAA1856 protein, eukaryotic





translation initiation factor 5

18716
987
NM_020075
eukaryotic translation initiation
DNA segment, Chr 1, ERATO Doi 692, expressed, ESTs, Highly similar to EUKARYOTIC
F




factor 5
TRANSLATION INITIATION FACTORS 5 [ R. norvegicus ], KIAA1856 protein, eukaryotic





translation initiation factor 5

15069
1111
NM_031840
farnesyl diphosphate synthase
ESTs, Moderately similar to A34713 farnesyl-pyrophosphate synthetase, testis - rat
H




(farnesyl pyrophosphate
[ R. norvegicus ], ESTs, Weakly similar to A34713 farnesyl-pyrophosphate synthetase,




synthetase,
testis - rat [ R. norvegicus ], farnesyl diphosphate synthase (farnesyl pyrophosphate




dimethylallyltranstransferase,
synthetase, dimethylallyltranstransferase, geranyltranstransferase)




geranyltranstransferase),




farnesyl diphosphate




synthetase

16476
1036
NM_024162
fatty acid binding protein 3,
EST, Moderately similar to FABH MOUSE FATTY ACID-BINDING PROTEIN, HEART
GENERAL, L




muscle and heart, fatty acid
[ M. musculus ], fatty acid binding protein 3, muscle and heart, fatty acid binding protein 3,




binding protein 3, muscle and
muscle and heart (mammary-derived growth inhibitor)




heart (mammary-derived




growth inhibitor)

20983
440
AI044900
fatty acid Coenzyme A ligase,
ESTs, Weakly similar to fatty acid Coenzyme A ligase, long chain 2; acetyl-Coenzyme A
K




long chain 2, fatty-acid-
synthetase; acetate-CoA ligase; acetyl-Coenzyme A synthetase 1 (ADP forming); acetyl-




Coenzyme A ligase, long-
CoA synthetase [ Mus musculus ] [ M. musculus ], Mus musculus , Similar to fatty-acid-




chain 2
Coenzyme A ligase, long-chain 6, clone MGC: 28744 IMAGE: 4481949, mRNA, complete





cds, Mus musculus , Similar to hypothetical protein FLJ20920, clone MGC: 25878





IMAGE: 4210220, mRNA, complete cds, fatty acid Coenzyme A ligase, long chain 2, fatty





acid Coenzyme A ligase, long chain 5, fatty-acid-Coenzyme A ligase, long-chain 1,





gonadotropin-regulated long chain acyl-CoA synthetase, lipidosis-related protein lipidosin

15926
1150
NM_053607
fatty acid Coenzyme A ligase,
ESTs, Weakly similar to fatty acid Coenzyme A ligase, long chain 2; acetyl-Coenzyme A
D




long chain 5, fatty-acid-
synthetase; acetate-CoA ligase; acetyl-Coenzyme A synthetase 1 (ADP forming); acetyl-




Coenzyme A ligase, long-
CoA synthetase [ Mus musculus ] [ M. musculus ], Mus musculus , Similar to fatty-acid-




chain 5
Coenzyme A ligase, long-chain 6, clone MGC: 28744 IMAGE: 4481949, mRNA, complete





cds, Mus musculus , Similar to hypothetical protein FLJ20920, clone MGC: 25878





IMAGE: 4210220, mRNA, complete cds, fatty acid Coenzyme A ligase, long chain 2, fatty





acid Coenzyme A ligase, long chain 5, fatty-acid-Coenzyme A ligase, long-chain 5,





hypothetical protein PRTD-NY3

13004
1154
NM_053623
fatty acid-Coenzyme A ligase,

J, L




long chain 4, fatty-acid-




Coenzyme A ligase, long-




chain 4

13005
1154
NM_053623
fatty acid-Coenzyme A ligase,

C




long chain 4, fatty-acid-




Coenzyme A ligase, long-




chain 4

8215
588
AI171692
ferritin light chain 1, ferritin,
ESTs, Moderately similar to ferritin light chain 1 [ Rattus norvegicus ] [ R. norvegicus ],
D




light polypeptide
ESTs, Moderately similar to FRL2 MOUSE FERRITIN LIGHT CHAIN 2 [ M. musculus ],





RIKEN cDNA 2010009K05 gene, RIKEN cDNA 4933416E14 gene, cysteine conjugate-





beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase),





ferritin light chain 1, ferritin light chain 2, ferritin light polypeptide

8211
1008
NM_022500
ferritin light chain 1, ferritin,
ESTs, Moderately similar to ferritin light chain 1 [ Rattus norvegicus ] [ R. norvegicus ],
H




light polypeptide
ESTs, Moderately similar to FRL2 MOUSE FERRITIN LIGHT CHAIN 2 [ M. musculus ],





RIKEN cDNA 4933416E14 gene, ferritin light chain 1, ferritin light chain 2, ferritin, light





polypeptide

8212
1008
NM_022500
ferritin light chain 1, ferritin,
ESTs, Moderately similar to ferritin light chain 1 [ Rattus norvegicus ] [ R. norvegicus ],
L




light polypeptide
ESTs, Moderately similar to FRL2 MOUSE FERRITIN LIGHT CHAIN 2 [ M. musculus ],





RIKEN cDNA 4933416E14 gene, ferritin light chain 1, ferritin light chain 2, ferritin, light





polypeptide

8210
1195
S61960
ferritin light chain 1, ferritin,
ESTs, Moderately similar to ferritin light chain 1 [ Rattus norvegicus ] [ R. norvegicus ],
GENERAL




light polypeptide
ESTs, Moderately similar to FRL2 MOUSE FERRITIN LIGHT CHAIN 2 [ M. musculus ],





RIKEN cDNA 4933416E14 gene, ferritin light chain 1, ferritin light chain 2, ferritin, light





polypeptide

6782
606
AI176170
FK506 binding protein 1A
FK506 binding protein 10 (65 kDa), FK506 binding protein 1A (12 kD), FK506 binding
B




(12 kD), FK506 binding protein
protein 1a (12 kDa), FK506 binding protein 5, FK506 binding protein 7 (23 kDa), FK506




1a (12 kDa)
binding protein 8 (38 kDa)

15295
887
NM_013102
FK506 binding protein 1A
FK506 binding protein 10 (65 kDa), FK506 binding protein 1A (12 kD), FK506 binding
GENERAL, H, I




(12 kD), FK506 binding protein
protein 1a (12 kDa), FK506 binding protein 5, FK506 binding protein 7 (23 kDa), FK506




1a (12 kDa), FK506 binding
binding protein 8 (38 kDa)




protein 2 (13 kDa), FK506




binding protein 2 (13 kD)

15296
887
NM_013102
FK506 binding protein 1A
FK506 binding protein 10 (65 kDa), FK506 binding protein 1A (12 kD), FK506 binding
H, I




(12 kD), FK506 binding protein
protein 1a (12 kDa), FK506 binding protein 5, FK506 binding protein 7 (23 kDa), FK506




1a (12 kDa), FK506 binding
binding protein 8 (38 kDa)




protein 2 (13 kDa), FK506




binding protein 2 (13 kD)

15297
887
NM_013102
FK506 binding protein 1A
FK506 binding protein 10 (65 kDa), FK506 binding protein 1A (12 kD), FK506 binding
K




(12 kD), FK506 binding protein
protein 1a (12 kDa), FK506 binding protein 5, FK506 binding protein 7 (23 kDa), FK506




1a (12 kDa), FK506 binding
binding protein 8 (38 kDa)




protein 2 (13 kDa), FK506




binding protein 2 (13 kD)

23445
849
NM_012792
flavin containing
EST, Weakly similar to FMO1 MOUSE DIMETHYLANILINE MONOOXYGENASE
GENERAL




monooxygenase 1
[ M. musculus ], ESTs, Weakly similar to S33758 flavin-containing monooxygenase 1 - rat





[ R. norvegicus ], Mus musculus flavin-containing monooxygenase 4 mRNA, complete cds,





expressed sequence AW107733, flavin containing monooxygenase 1, hypothetical





protein PRO1257

23961
929
NM_017181
fumarylacetoacetate
ESTs, Weakly similar to FAAA_RAT Fumarylacetoacetase (Fumarylacetoacetate
GENERAL, E, G, I




hydrolase,
hydrolase) (Beta-diketonase) (FAA) [ R. norvegicus ], fumarylacetoacetate hydrolase,




fumarylacetoacetate hydrolase
fumarylacetoacetate hydrolase (fumarylacetoacetase)




(fumarylacetoacetase)

23151
1000
NM_022005
FXYD domain-containing ion

B, L




transport regulator 6

45
904
NM_016996
G protein-coupled receptor,
ESTs, Highly similar to 2121236A Ca-sensing receptor [ H. sapiens ], ESTs, Weakly similar
GENERAL, J, L




family C, group 2, member A,
to CASR_MOUSE EXTRACELLULAR CALCIUM-SENSING RECEPTOR PRECURSOR




calcium-sensing receptor
(CASR) (PARATHYROID CELL CALCIUM-SENSING RECEPTOR) [ M. musculus ], G




(hypocalciuric hypercalcemia
protein-coupled receptor, family C, group 2, member A, RIKEN cDNA 1700108E19 gene,




1, severe neonatal
calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal




hyperparathyroidism)
hyperparathyroidism), taste receptor, type 1, member 1, vomeronasal 2, receptor, 10,





vomeronasal 2, receptor, 11, vomeronasal 2, receptor, 13, vomeronasal 2, receptor, 5,





vomeronasal 2, receptor 9

1143
971
NM_019280
gap junction membrane
gap junction membrane channel protein alpha 5, gap junction protein, alpha 5, 40 kD
A




channel protein alpha 5, gap
(connexin 40)




junction protein, alpha 5, 40 kD




(connexin 40)

15072
726
AI234969
GATA binding protein 4
GATA binding protein 4, GATA binding protein 5, trichorhinophalangeal syndrome I,
A





trichorhinophalangeal syndrome I (human)

5496
1083
NM_031589
glucose-6-phosphatase,
Mus musculus , Similar to solute carrier family 37 (glycerol-3-phosphate transporter),
GENERAL, D, E




transport (glucose-6-
member 1, clone MGC: 28167 IMAGE: 3985469, mRNA, complete cds, glucose-6-




phosphate) protein 1, glucose-
phosphatase, transport (glucose-6-phosphate) protein 1, glucose-6-phosphatase,




6-phosphatase, transport
transport protein 1, solute carrier family 37 (glycerol-3-phosphate transporter), member 1




protein 1

5497
1083
NM_031589
glucose-6-phosphatase,
Mus musculus , Similar to solute carrier family 37 (glycerol-3-phosphate transporter),
GENERAL, D, E




transport (glucose-6-
member 1, clone MGC: 28167 IMAGE: 3985469, mRNA, complete cds, glucose-6-




phosphate) protein 1, glucose-
phosphatase, transport (glucose-6-phosphate) protein 1, glucose-6-phosphatase,




6-phosphatase, transport
transport protein 1, solute carrier family 37 (glycerol-3-phosphate transporter), member 1




protein 1

1399
907
NM_017006
glucose-6-phosphate
glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase 2, glucose-6-
GENERAL, H, I




dehydrogenase, glucose-6-
phosphate dehydrogenase X-linked, hexose-6-phosphate dehydrogenase (glucose 1-




phosphate dehydrogenase X-
dehydrogenase)




linked

14003
948
NM_017305
glutamate-cysteine ligase,
glutamate-cysteine ligase, modifier subunit, glutamate-cysteine ligase, modifier subunit
B, J




modifier subunit, glutamate-




cysteine ligase, modifier




subunit

1247
792
J05181
glutamate-cysteine ligase,
Homo sapiens , Similar to glutamate-cysteine ligase, catalytic subunit, clone MGC: 26341
J




catalytic subunit
IMAGE: 4814728, mRNA, complete cds, glutamate-cysteine ligase, catalytic subunit

5206
235
AA925755
glutaminase
ESTs, Highly similar to GLSK RAT GLUTAMINASE, KIDNEY ISOFORM PRECURSOR
E





[ R. norvegicus ], ESTs, Moderately similar to GLSK_HUMAN GLUTAMINASE, KIDNEY





ISOFORM, MITOCHONDRIAL PRECURSOR (GLS) (L-GLUTAMINE





AMIDOHYDROLASE) (K-GLUTAMINASE) [ H. sapiens ], Homo sapiens glutaminase





isoform M precursor, mRNA, complete cds, expressed sequence AI314027, glutaminase

18990
1072
NM_031509
glutathione S-transferase A2,
ESTs, Weakly similar to GTA1_RAT GLUTATHIONE S-TRANSFERASE YA (LIGANDIN)
H




glutathione S-transferase,
(CHAIN 1) (GST CLASS-ALPHA) (CLONES PGST94 & PGTR261) [ R. norvegicus ],




alpha 2 (Yc2)
glutathione S-transferase A2, glutathione S-transferase, alpha 2 (Yc2)

21012
788
J02592
glutathione S-transferase M2

B




(muscle), glutathione S-




transferase, mu 2

21014
791
J03914
glutathione S-transferase M2

B, L




(muscle), glutathione S-




transferase, mu 2

6405
801
L38615
glutathione synthetase
EST, Highly similar to GSHB MOUSE GLUTATHIONE SYNTHETASE [ M. musculus ],
G





glutathione synthetase

16775
1048
NM_031031
glycine amidinotransferase (L-
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GENERAL, D, I, L




arginine:glycine




amidinotransferase)

1551
915
NM_017084
glycine N-methyltransferase
glycine N-methyltransferase
G

16756
38
AA818089
glycyl-tRNA synthetase
glycyl-tRNA synthetase
GENERAL, A, I

352
1030
NM_024127
growth arrest and DNA-
growth arrest and DNA-damage-inducible 45 alpha, growth arrest and DNA-damage-
H




damage-inducible 45 alpha,
inducible 45 beta, growth arrest and DNA-damage-inducible, alpha




growth arrest and DNA-




damage-inducible, alpha

353
1030
NM_024127
growth arrest and DNA-
growth arrest and DNA-damage-inducible 45 alpha, growth arrest and DNA-damage-
GENERAL, H, I




damage-inducible 45 alpha,
inducible 45 beta, growth arrest and DNA-damage-inducible, alpha




growth arrest and DNA-




damage-inducible, alpha

354
1030
NM_024127
growth arrest and DNA-
growth arrest and DNA-damage-inducible 45 alpha, growth arrest and DNA-damage-
GENERAL, H, I




damage-inducible 45 alpha,
inducible 45 beta, growth arrest and DNA-damage-inducible, alpha




growth arrest and DNA-




damage-inducible, alpha

25290
1174
NM_057100
growth arrest specific 6,
ESTs, Highly similar to growth arrest specific 6 [ Rattus norvegicus ] [ R. norvegicus ],
J




growth arrest-specific 6
growth arrest specific 6, growth arrest-specific 6

17524
381
AI010568
growth hormone receptor
growth hormone receptor
GENERAL, A, I

10887
917
NM_017094
growth hormone receptor
growth hormone receptor
GENERAL, I

16948
850
NM_012793
guanidinoacetate N-
expressed sequence AA571402, guanidinoacetate N-methyltransferase,
A, C




methyltransferase,
guanidinoacetate methyltransferase




guanidinoacetate




methyltransferase

8888
916
NM_017090
guanylate cyclase 1, soluble,
ESTs, Weakly similar to CYG3 RAT GUANYLATE CYCLASE SOLUBLE, ALPHA-1
B




alpha 3
CHAIN [ R. norvegicus ], guanylate cyclase 1, soluble, alpha 3

17661
1025
NM_022674
H2A histone family, member Z
EST, Weakly similar to histone H2A.F/Z variant [ Homo sapiens ] [ H. sapiens ], ESTs,
E





Highly similar to S03644 histone H2A.Z - rat [ R. norvegicus ], ESTs, Weakly similar to





H2AZ_HUMAN HISTONE H2A [ H. sapiens ], H2A histone family, member Z, Homo





sapiens cDNA FLJ32241 fis, clone PLACE6005231, RIKEN cDNA C530002L11 gene,





histone H2A.F/Z variant

1687
645
AI179971
hemoglobin alpha, adult chain
EST, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-2 CHAINS
J




2, hemoglobin, alpha 1
[ R. norvegicus ], EST, Weakly similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-





2 CHAINS [ R. norvegicus ], ESTs, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA





1 AND ALPHA-2 CHAINS [ R. norvegicus ], RIKEN cDNA 2510042H12 gene, hemoglobin





alpha chain complex, hemoglobin alpha, adult chain 1, hemoglobin, alpha 1, hemoglobin,





alpha 2, hemoglobin, theta 1

1684
885
NM_013096
hemoglobin alpha, adult chain
EST, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-2 CHAINS
J




2, hemoglobin, alpha 1
[ R. norvegicus ], EST, Weakly similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-





2 CHAINS [ R. norvegicus ], ESTs, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA





1 AND ALPHA-2 CHAINS [ R. norvegicus ], RIKEN cDNA 2510042H12 gene, hemoglobin





alpha chain complex, hemoglobin alpha, adult chain 1, hemoglobin, alpha 1, hemoglobin,





alpha 2, hemoglobin, theta 1

1685
885
NM_013096
hemoglobin alpha, adult chain
EST, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-2 CHAINS
J




2, hemoglobin, alpha 1
[ R. norvegicus ], EST, Weakly similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-





2 CHAINS [ R. norvegicus ], ESTs, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA





1 AND ALPHA-2 CHAINS [ R. norvegicus ], RIKEN cDNA 2510042H12 gene, hemoglobin





alpha chain complex, hemoglobin alpha, adult chain 1, hemoglobin, alpha 1, hemoglobin,





alpha 2, hemoglobin, theta 1

1688
885
NM_013096
hemoglobin alpha, adult chain
EST, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-2 CHAINS
J




2, hemoglobin, alpha 1
[ R. norvegicus ], EST, Weakly similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-





2 CHAINS [ R. norvegicus ], ESTs, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA





1 AND ALPHA-2 CHAINS [ R. norvegicus ], RIKEN cDNA 2510042H12 gene, hemoglobin





alpha chain complex, hemoglobin alpha, adult chain 1, hemoglobin, alpha 1, hemoglobin,





alpha 2, hemoglobin, theta 1

1689
885
NM_013096
hemoglobin alpha, adult chain
EST, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-2 CHAINS
J




2, hemoglobin, alpha 1
[ R. norvegicus ], EST, Weakly similar to HBA_RAT HEMOGLOBIN ALPHA-1 AND ALPHA-





2 CHAINS [ R. norvegicus ], ESTs, Moderately similar to HBA_RAT HEMOGLOBIN ALPHA





1 AND ALPHA-2 CHAINS [ R. norvegicus ], RIKEN cDNA 2510042H12 gene, hemoglobin





alpha chain complex, hemoglobin alpha, adult chain 1, hemoglobin, alpha 1, hemoglobin,





alpha 2, hemoglobin, theta 1

25468
1123
NM_033234
hemoglobin beta chain
EST, Moderately similar to HBB1_RAT Hemoglobin beta chain, major-form
J




complex, hemoglobin, beta
[ R. norvegicus ], expressed sequence AI036344, hemoglobin, beta, hemoglobin, beta adult





major chain, hemoglobin, beta adult minor chain, hemoglobin, delta

17829
1123
NM_033234
hemoglobin beta chain
EST, Moderately similar to HBB1_RAT Hemoglobin beta chain, major-form
J




complex, hemoglobin, beta
[ R. norvegicus ], expressed sequence AI036344, hemoglobin, beta, hemoglobin, beta adult





major chain, hemoglobin, beta adult minor chain, hemoglobin, delta

17832
1123
NM_033234
hemoglobin beta chain
EST, Moderately similar to HBB1_RAT Hemoglobin beta chain, major-form
J




complex, hemoglobin, beta
[ R. norvegicus ], expressed sequence AI036344, hemoglobin, beta, hemoglobin, beta adult





major chain, hemoglobin, beta adult minor chain, hemoglobin, delta

17833
1123
NM_033234
hemoglobin beta chain
EST, Moderately similar to HBB1_RAT Hemoglobin beta chain, major-form
F




complex, hemoglobin, beta
[ R. norvegicus ], expressed sequence AI036344, hemoglobin, beta, hemoglobin, beta adult





major chain, hemoglobin, beta adult minor chain, hemoglobin, delta

6758
405
AI013394
heparan sulfate (glucosamine)
EST, Highly similar to HSS2 MOUSE HEPARIN SULFATE N-DEACETYLASE/N-
B, L




3-O-sulfotransferase 1
SULFOTRANSFERASE [ M. musculus ], ESTs, Weakly similar to HSS2 MOUSE HEPARIN





SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE [ M. musculus ], ESTs, Weakly





similar to HSS2_HUMAN HEPARIN SULFATE N-DEACETYLASE/N-





SULFOTRANSFERASE [ H. sapiens ], N-deacetylase/N-sulfotransferase (heparan





glucosaminyl) 2,N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3,N-





deacetylase/N-sulfotransferase (heparin glucosaminyl) 4,N-deacetylase/N-





sulfotransferase 4, RIKEN cDNA 4930439H17 gene, heparan sulfate (glucosamine) 3-O-





sulfotransferase 3A heparan sulfate (glucosamine) 3-O-sulfotransferase 4

4234
1068
NM_031330
heterogeneous nuclear
DAZ associated protein 1, Musashi homolog 1( Drosophila ), Musashi homolog 2
K




ribonucleoprotein A/B
( Drosophila ), RIKEN cDNA 4933434H11 gene, expressed sequence AA959857,





heterogeneous nuclear ribonucleoprotein A/B, musashi homolog 1 ( Drosophila )

4235
1068
NM_031330
heterogeneous nuclear
DAZ associated protein 1, Musashi homolog 1( Drosophila ), Musashi homolog 2
GENERAL, H, K, L




ribonucleoprotein A/B
( Drosophila ), RIKEN cDNA 4933434H11 gene, expressed sequence AA959857,





heterogeneous nuclear ribonucleoprotein A/B, musashi homolog 1 ( Drosophila )

19834
1179
NM_057139
heterogeneous nuclear
E1B-55 kDa-associated protein 5, EST, Weakly similar to heterogenous nuclear
E




ribonucleoprotein U,
ribonucleoprotein U; scaffold attachment factor A; nuclear matrix protein sp120 [ Mus




heterogeneous nuclear
musculus ] [ M. musculus ], expressed sequence AI465155, heterogeneous nuclear




ribonucleoprotein U (scaffold
ribonucleoprotein U




attachment factor A)

15437
930
NM_017187
high mobility group box 2, high
EST, Moderately similar to HMG2_RAT High mobility group protein 2 (HMG-2)
E




mobility group (nonhistone
[ R. norvegicus ], ESTs, Weakly similar to 2001363A high mobility group protein 2




chromosomal) protein 2
[ H. sapiens ], ESTs, Weakly similar to HMG2_RAT High mobility group protein 2 (HMG-2)





[ R. norvegicus ], Homo sapiens , clone MGC: 33358 IMAGE: 5266418, mRNA, complete





cds, RIKEN cDNA 2610021J01 gene, expressed sequence C80539, high mobility group





box 2 high-mobility group (nonhistone chromosomal) protein 2

3608
1049
NM_031044
histamine N-methyltransferase
histamine N-methyltransferase
GENERAL, J

3610
1049
NM_031044
histamine N-methyltransferase
histamine N-methyltransferase
GENERAL, G, I, J

3609
1203
S82579
histamine N-methyltransferase
histamine N-methyltransferase
F

17345
144
AA892014
HLA-B associated transcript 1,
ESTs, Highly similar to S33681 translation initiation factor elF-4A.I [ H. sapiens ], ESTs,
E




HLA-B-associated transcript
Weakly similar to A42811 nuclear RNA helicase (DEAD family) homolog - rat




1A
[ R. norvegicus ], RIKEN cDNA 2610307C23 gene, hypothetical protein MGC6664

15750
1131
NM_053309
Homer, neuronal immediate
Homer, neuronal immediate early gene, 2 homer, neuronal immediate early gene, 1
H




early gene, 2, homer, neuronal




immediate early gene, 2

24631
1032
NM_024137
human immunodeficiency virus
KIAA1555 protein, human immunodeficiency virus type I enhancer binding protein 2,
F




type I enhancer binding protein 2
human immunodeficiency virus type I enhancer binding protein 3, kappa B and Rss





recognition component

573
692
AI232087
hydroxyacid oxidase (glycolate

J




oxidase) 3, hydroxyacid




oxidase 3 (medium-chain)

1409
1124
NM_033349
hydroxyacyl glutathione
ESTs, Highly similar to GLO2_HUMAN HYDROXYACYLGLUTATHIONE HYDROLASE
GENERAL, A, C, E, F




hydrolase
[ H. sapiens ], Mus musculus , Similar to hydroxyacyl glutathione hydrolase, clone





MGC: 6697 IMAGE: 3583919, mRNA, complete cds, RIKEN cDNA 0610025L15 gene,





RIKEN cDNA 1500017E18 gene, brain protein 17, hydroxyacyl glutathione hydrolase

15175
1091
NM_031682
hydroxyacyl-Coenzyme A
hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxysteroid (17-beta)
E




dehydrogenase, type II,
dehydrogenase 10, retinal short-chain dehydrogenase/reductase retSDR3




hydroxysteroid (17-beta)




dehydrogenase 10

275
914
NM_017081
hydroxysteroid (11-beta)
hydroxysteroid (11-beta) dehydrogenase 2, hydroxysteroid 11-beta dehydrogenase 2
GENERAL




dehydrogenase 2,




hydroxysteroid 11-beta




dehydrogenase 2

10464
793
J05510
inositol 1,4,5-triphosphate
ESTs, Highly similar to A36579 inositol 1,4,5-triphosphate receptor 1 - rat [ R. norvegicus ],
GENERAL, I




receptor 1, inositol 1,4,5-
ESTs, Highly similar to IP3R MOUSE INOSITOL 1,4,5-TRISPHOSPHATE-BINDING




triphosphate receptor, type 1
PROTEIN TYPE 1 RECEPTOR [ M. musculus ], ESTs, Highly similar to S54974 type 1





inositol 1,4,5-trisphosphate receptor [ H. sapiens ], ESTs, Moderately similar to IP3R





MOUSE INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN TYPE 1 RECEPTOR





[ M. musculus ], ESTs, Weakly similar to IP3R MOUSE INOSITOL 1,4,5-





TRISPHOSPHATE-BINDING PROTEIN TYPE 1 RECEPTOR [ M. musculus ], inositol 1,4,5





triphosphate receptor 1, inositol 1,4,5-triphosphate receptor, type 1

1712
892
NM_013138
inositol 1,4,5-triphosphate
ESTs, Highly similar to IP3R MOUSE INOSITOL 1,4,5-TRISPHOSPHATE-BINDING
GENERAL




receptor 3, inositol 1,4,5-
PROTEIN TYPE 1 RECEPTOR [ M. musculus ], ESTs, Moderately similar to IP3R MOUSE




triphosphate receptor, type 3
INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN TYPE 1 RECEPTOR





[ M. musculus ], ESTs, Moderately similar to IP3S_MOUSE_1 [Segment 1 of 2] Inositol





1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2





InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V





receptor) (Fragments) [ M. musculus ], ESTs, Weakly similar to IP3R MOUSE INOSITOL





1,4,5-TRISPHOSPHATE-BINDING PROTEIN TYPE 1 RECEPTOR [ M. musculus ],





inositol 1,4,5-triphosphate receptor 1, inositol 1,4,5-triphosphate receptor 3, inositol 1,4,5-





triphosphate receptor type 3

21053
805
M15481
insulin-like growth factor 1,

GENERAL




insulin-like growth factor 1




(somatomedin C)

24893
853
NM_012817
insulin-like growth factor

B




binding protein 5

21977
1133
NM_053329
insulin-like growth factor
ESTs, Weakly similar to A41915 insulin-like growth factor-binding complex acid-labile
A, B




binding protein, acid labile
chain precursor [ H. sapiens ], ESTs, Weakly similar to ALS MOUSE INSULIN-LIKE




subunit
GROWTH FACTOR BINDING PROTEIN COMPLEX ACID LABILE CHAIN





PRECURSOR [ M. musculus ], RIKEN cDNA 1200009O22 gene, glycoprotein A repetitions





predominant, glycoprotein lb (platelet), alpha polypeptide, insulin-like growth factor





binding protein, acid labile subunit, toll-like receptor 3, toll-like receptor 4, toll-like receptor 5

14989
621
AI177366
integrin beta 1 (fibronectin
integrin beta 1 (fibronectin receptor beta), integrin beta 2, integrin beta 7, integrin, beta 1
GENERAL, K




receptor beta), integrin, beta 1
(fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), integrin,




(fibronectin receptor, beta
beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage




polypeptide, antigen CD29
antigen 1 (mac-1) beta subunit), integrin, beta 7




includes MDF2, MSK12)

2554
873
NM_012967
intercellular adhesion
ESTs, Weakly similar to ICA1_HUMAN INTERCELLULAR ADHESION MOLECULE-1
GENERAL




molecule, intercellular
PRECURSOR [ H. sapiens ], intercellular adhesion molecule, intercellular adhesion




adhesion molecule 1 (CD54),
molecule 1 (CD54), human rhinovirus receptor, intercellular adhesion molecule 3,




human rhinovirus receptor
intercellular adhesion molecule 5, telencephalin

2555
873
NM_012967
intercellular adhesion
ESTs, Weakly similar to ICA1_HUMAN INTERCELLULAR ADHESION MOLECULE-1
GENERAL, C, I




molecule, intercellular
PRECURSOR [ H. sapiens ], intercellular adhesion molecule, intercellular adhesion




adhesion molecule 1 (CD54),
molecule 1 (CD54), human rhinovirus receptor, intercellular adhesion molecule 3,




human rhinovirus receptor
intercellular adhesion molecule 5, telencephalin

20126
826
NM_012591
interferon regulatory factor 1
ESTs, Moderately similar to sirtuin 2 (silent mating type information regulation 2,
K





homolog) 2 ( S. cerevisiae ) [ Rattus norvegicus ] [ R. norvegicus ], Mus musculus , Similar to





sirtuin silent mating type information regulation 2 homolog 7 ( S. cerevisiae ), clone





MGC: 37560 IMAGE: 4987746, mRNA, complete cds, expressed sequence AI646973,





interferon regulatory factor 1, interferon regulatory factor 2, interferon regulatory factor 4,





interferon regulatory factor 5, sirtuin 1 ((silent mating type information regulation 2,





homolog) 1 ( S. cerevisiae ), sirtuin 2 (silent mating type information regulation 2, homolog)





2 ( S. cerevisiae ), sirtuin 3 (silent mating type information regulation 2, homolog) 3 ( S. cerevisiae )

17908
967
NM_019242
interferon-related
ESTs, Weakly similar to IFR1_RAT INTERFERON-RELATED DEVELOPMENTAL
GENERAL




developmental regulator 1
REGULATOR 1 (NERVE GROWTH FACTOR-INDUCIBLE PROTEIN PC4) (IRPR)





[ R. norvegicus ], interferon-related developmental regulator 1, interferon-related





developmental regulator 2

4449
827
NM_012592
isovaleryl Coenzyme A
ESTs, Moderately similar to IVD_HUMAN ISOVALERYL-COA DEHYDROGENASE,
B, G, K




dehydrogenase, isovaleryl
MITOCHONDRIAL PRECURSOR [ H. sapiens ], isovaleryl Coenzyme A dehydrogenase,




coenzyme A dehydrogenase
isovaleryl coenzyme A dehydrogenase

4450
827
NM_012592
isovaleryl Coenzyme A
ESTs, Moderately similar to IVD_HUMAN ISOVALERYL-COA DEHYDROGENASE,
E




dehydrogenase, isovaleryl
MITOCHONDRIAL PRECURSOR [ H. sapiens ], isovaleryl Coenzyme A dehydrogenase,




coenzyme A dehydrogenase
isovaleryl coenzyme A dehydrogenase

4451
827
NM_012592
isovaleryl Coenzyme A
ESTs, Moderately similar to IVD_HUMAN ISOVALERYL-COA DEHYDROGENASE,
GENERAL, F




dehydrogenase, isovaleryl
MITOCHONDRIAL PRECURSOR [ H. sapiens ], isovaleryl Coenzyme A dehydrogenase,




coenzyme A dehydrogenase
isovaleryl coenzyme A dehydrogenase

1729
961
NM_019147
jagged 1, jagged 1 (Alagille
jagged 1, jagged 1 (Alagille syndrome)
B




syndrome)

25233
774
AJ000556
Janus kinase 1, Janus kinase

E




1 (a protein tyrosine kinase)

2632
965
NM_019213
jumping translocation
ESTs, Highly similar to jumping translocation breakpoint [ Rattus norvegicus ]
A, D




breakpoint
[ R. norvegicus ], ESTs, Moderately similar to jumping translocation breakpoint [ Rattus





norvegicus ] [ R. norvegicus ], jumping translocation breakpoint

22352
603
AI175959
Jun oncogene, v-jun sarcoma
Jun oncogene, v-jun sarcoma virus 17 oncogene homolog (avian)
GENERAL, H




virus 17 oncogene homolog




(avian)

17198
828
NM_012593
kallikrein 1,
EST, Highly similar to KLKC_HUMAN KALLIKREIN 12 PRECURSOR [ H. sapiens ],
G




renal/pancreas/salivary
kallikrein 1, renal/pancreas/salivary, kallikrein 24, kallikrein 27, kallikrein 5




kallikrein 6

16726
1112
NM_031855
ketohexokinase,
ketohexokinase, ketohexokinase (fructokinase)
GENERAL, E, G, H, I




ketohexokinase (fructokinase)

1850
840
NM_012696
kininogen
kininogen
GENERAL

8640
1184
NM_057211
Kruppel-like factor 9, basic
ESTs, Moderately similar to Kruppel-like factor 9 [ Rattus norvegicus ] [ R. norvegicus ],
D




transcription element binding
Kruppel-like factor 9, basic transcription element binding protein 1, expressed sequence




protein 1
AL022736

794
1166
NM_053902
kynureninase (L-kynurenine
Mus musculus , Similar to kynureninase (L-kynurenine hydrolase), clone MGC: 30315
GENERAL, I




hydrolase)
IMAGE: 5136970, mRNA, complete cds, kynureninase (L-kynurenine hydrolase)

17807
909
NM_017025
lactate dehydrogenase 1, A
lactate dehydrogenase 1, A chain, lactate dehydrogenase A, lactate dehydrogenase A-
GENERAL, G




chain, lactate dehydrogenase A
like, lactate dehydrogenase C

7124
829
NM_012595
lactate dehydrogenase 2, B
lactate dehydrogenase 2, B chain, lactate dehydrogenase B
E




chain, lactate dehydrogenase B

20086
403
AI013260
lamin A, lamin A/C

GENERAL, H

20085
997
NM_021755
lamin A, lamin A/C

C

22434
874
NM_012974
laminin, beta 2, laminin, beta 2
ESTs, Weakly similar to LMB2_HUMAN LAMININ BETA-2 CHAIN PRECURSOR
F




(laminin S)
[ H. sapiens ], Rattus norvegicus laminin-5 alpha 3 chain mRNA, complete cds, expressed





sequence AW211941, expressed sequence C80098, hypothetical protein BC018697,





laminin B1 subunit 1, laminin, beta 1, laminin, beta 2, laminin, beta 2 (laminin S), laminin,





beta 4

1993
1089
NM_031655
latexin, latexin protein
ESTs, Weakly similar to latexin [ Rattus norvegicus ] [ R. norvegicus ], latexin, retinoic acid
GENERAL, E, G, K





receptor responder (tazarotene induced) 1

22321
1109
NM_031832
lectin, galactose binding,
EST, Weakly similar to A35820 galectin 3 [ H. sapiens ], galectin-related inter-fiber protein,
GENERAL, B, G, L




soluble 3, lectin, galactoside-
lectin, galactoside-binding, soluble, 3 (galectin 3)




binding, soluble, 3 (galectin 3)

783
859
NM_012859
lipase, hormone sensitive,
EST, Highly similar to hormone - sensitive lipase, testicular isofom [ Rattus norvegicus ]
F




lipase, hormone-sensitive
[ R. norvegicus ], lipase, hormone sensitive, lipase, hormone-sensitive

1542
932
NM_017193
L-kynurenine/alpha-

J




aminoadipate




aminotransferase, kynurenine




aminotransferase II

15110
1043
NM_030827
low density lipoprotein
EST, Highly similar to T42737 gp330 protein precursor - rat [ R. norvegicus ], EST,
GENERAL, I




receptor-related protein 2, low
Moderately similar to S25111 alpha-2-macroglobulin receptor precursor - mouse




density lipoprotein-related
[ M. musculus ], ESTs, Highly similar to S25111 alpha-2-macroglobulin receptor precursor -




protein 2
mouse [ M. musculus ], ESTs, Weakly similar to LDVR MOUSE VERY LOW-DENSITY





LIPOPROTEIN RECEPTOR PRECURSOR [ M. musculus ], ESTs, Weakly similar to





S25111 alpha-2-macroglobulin receptor precursor - mouse [ M. musculus ], expressed





sequence AI315343, low density lipoprotein receptor-related protein 1, low density





lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), low density lipoprotein-





related protein 2

15111
1043
NM_030827
low density lipoprotein
EST, Highly similar to T42737 gp330 protein precursor - rat [ R. norvegicus ], EST,
GENERAL, I




receptor-related protein 2, low
Moderately similar to S25111 alpha-2-macroglobulin receptor precursor - mouse




density lipoprotein-related
[ M. musculus ], ESTs, Highly similar to S25111 alpha-2-macroglobulin receptor precursor -




protein 2
mouse [ M. musculus ], ESTs, Weakly similar to LDVR MOUSE VERY LOW-DENSITY





LIPOPROTEIN RECEPTOR PRECURSOR [ M. musculus ], ESTs, Weakly similar to





S25111 alpha-2-macroglobulin receptor precursor - mouse [ M. musculus ], expressed





sequence AI315343, low density lipoprotein receptor-related protein 1, low density





lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), low density lipoprotein-





related protein 2

15112
1043
NM_030827
low density lipoprotein
EST, Highly similar to T42737 gp330 protein precursor - rat [ R. norvegicus ], EST,
I




receptor-related protein 2, low
Moderately similar to S25111 alpha-2-macroglobulin receptor precursor - mouse




density lipoprotein-related
[ M. musculus ], ESTs, Highly similar to S25111 alpha-2-macroglobulin receptor precursor -




protein 2
mouse [ M. musculus ], ESTs, Weakly similar to LDVR MOUSE VERY LOW-DENSITY





LIPOPROTEIN RECEPTOR PRECURSOR [ M. musculus ], ESTs, Weakly similar to





S25111 alpha-2-macroglobulin receptor precursor - mouse [ M. musculus ], expressed





sequence AI315343, low density lipoprotein receptor-related protein 1, low density





lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), low density lipoprotein-





related protein 2

1943
912
NM_017061
lysyl oxidase
ESTs, Moderately similar to LYOX_HUMAN PROTEIN-LYSINE 6-OXIDASE
L





PRECURSOR [ H. sapiens ], ESTs, Moderately similar to LYOX_RAT Protein-lysine 6-





oxidase precursor (Lysyl oxidase) [ R. norvegicus ], ESTs, Weakly similar to LYOX_RAT





Protein-lysine 6-oxidase precursor (Lysyl oxidase) [ R. norvegicus ], lysyl oxidase, lysyl





oxidase-like, lysyl oxidase-like 1, lysyl oxidase-like 2

1946
912
NM_017061
lysyl oxidase
ESTs, Moderately similar to LYOX_HUMAN PROTEIN-LYSINE 6-OXIDASE
F





PRECURSOR [ H. sapiens ], ESTs, Moderately similar to LYOX_RAT Protein-lysine 6-





oxidase precursor (Lysyl oxidase) [ R. norvegicus ], ESTs, Weakly similar to LYOX_RAT





Protein-lysine 6-oxidase precursor (Lysyl oxidase) [ R. norvegicus ], lysyl oxidase, lysyl





oxidase-like, lysyl oxidase-like 1, lysyl oxidase-like 2

15242
964
NM_019191
MAD homolog 2 ( Drosophila ),
MAD homolog 2 ( Drosophila ), MAD, mothers against decapentaplegic homolog 2
D




MAD, mothers against
( Drosophila )




decapentaplegic homolog 2




( Drosophila )

24437
931
NM_017190
malignancy-associated
CD33 antigen (gp67), ESTs, Weakly similar to MAG_RAT Myelin-associated glycoprotein
A




protein, myelin-associated
precursor (L-MAG/S-MAG) (Brain neuron cytoplasmic protein 3) [ R. norvegicus ], Mus




glycoprotein
musculus sialic acid-binding lectin Siglec-F mRNA, complete cds, myelin-associated





glycoprotein, sialic acid binding Ig-like lectin 5

13151
860
NM_012862
matrix Gla protein, matrix
EST, Weakly similar to MGP_HUMAN MATRIX GLA-PROTEIN PRECURSOR
GENERAL




gamma-carboxyglutamate
[ H. sapiens ], ESTs, Highly similar to MGP_HUMAN MATRIX GLA-PROTEIN




(gla) protein
PRECURSOR [ H. sapiens ], matrix Gla protein, matrix gamma-carboxyglutamate (gla)





protein

16676
762
AI639082
MCM6 minichromosome
EST, Weakly similar to MCM5_HUMAN DNA REPLICATION LICENSING FACTOR
E




maintenance deficient 6 (MIS5
MCM5 [ H. sapiens ], ESTs, Weakly similar to MCM6_HUMAN DNA REPLICATION




homolog, S. pombe ) ( S. cerevisiae ),
LICENSING FACTOR MCM6 [ H. sapiens ], MCM2 minichromosome maintenance




mini chromosome
deficient 2, mitotin ( S. cerevisiae ), MCM6 minichromosome maintenance deficient 6




maintenance deficient 6 ( S. cerevisiae )
(MIS5 homolog, S. pombe ) ( S. cerevisiae ), mini chromosome maintenance deficient 2 ( S. cerevisiae ),





mini chromosome maintenance deficient 5 ( S. cerevisiae ), mini chromosome





maintenance deficient 6 ( S. cerevisiae ), mini chromosome maintenance deficient 7 ( S. cerevisiae )

16674
1208
U17565
MCM6 minichromosome
EST, Weakly similar to MCM5_HUMAN DNA REPLICATION LICENSING FACTOR
E




maintenance deficient 6 (MIS5
MCM5 [ H. sapiens ], ESTs, Weakly similar to MCM6_HUMAN DNA REPLICATION




homolog, S. pombe ) ( S. cerevisiae ),
LICENSING FACTOR MCM6 [ H. sapiens ], MCM2 minichromosome maintenance




mini chromosome
deficient 2, mitotin ( S. cerevisiae ), MCM6 minichromosome maintenance deficient 6




maintenance deficient 6 ( S. cerevisiae )
(MIS5 homolog, S. pombe ) ( S. cerevisiae ), mini chromosome maintenance deficient 2 ( S. cerevisiae ),





mini chromosome maintenance deficient 5 ( S. cerevisiae ), mini chromosome





maintenance deficient 6 ( S. cerevisiae ), mini chromosome maintenance deficient 7 ( S. cerevisiae )

16675
1208
U17565
MCM6 minichromosome
EST, Weakly similar to MCM5_HUMAN DNA REPLICATION LICENSING FACTOR
E




maintenance deficient 6 (MIS5
MCM5 [ H. sapiens ], ESTs, Weakly similar to MCM6_HUMAN DNA REPLICATION




homolog, S. pombe ) ( S. cerevisiae ),
LICENSING FACTOR MCM6 [ H. sapiens ], MCM2 minichromosome maintenance




mini chromosome
deficient 2, mitotin ( S. cerevisiae ), MCM6 minichromosome maintenance deficient 6




maintenance deficient 6 ( S. cerevisiae )
(MIS5 homolog, S. pombe ) ( S. cerevisiae ), mini chromosome maintenance deficient 2 ( S. cerevisiae ),





mini chromosome maintenance deficient 5 ( S. cerevisiae ), mini chromosome





maintenance deficient 6 ( S. cerevisiae ), mini chromosome maintenance deficient 7 ( S. cerevisiae )

17933
1122
NM_032615
membrane interacting protein

K




of RGS16

5837
893
NM_013143
meprin 1 alpha, meprin A,
expressed sequence AI098089, meprin 1 alpha, meprin A, alpha (PABA peptide
GENERAL, F




alpha (PABA peptide
hydrolase)




hydrolase)

5838
893
NM_013143
meprin 1 alpha, meprin A,
expressed sequence AI098089, meprin 1 alpha, meprin A, alpha (PABA peptide
GENERAL, F, G




alpha (PABA peptide
hydrolase)




hydrolase)

17357
899
NM_013183
meprin 1 beta, meprin A, beta
EST, Weakly similar to A48040 meprin A [ M. musculus ], expressed sequence C87576,
GENERAL, F, G, I, L





meprin 1 beta, meprin A, beta

16354
782
D50564
mercaptopyruvate
ESTs, Moderately similar to THTM_RAT 3-MERCAPTOPYRUVATE
C




sulfurtransferase
SULFURTRANSFERASE (MST) [ R. norvegicus ], mercaptopyruvate sulfurtransferase,





thiosulfate sulfurtransferase, mitochondrial

15190
503
AI102562
metallothionein 1,
EST, Moderately similar to Cd-7 Metallothionein-2 [ H. sapiens ], EST, Moderately similar to
GENERAL




metallothionein 1A (functional)
SMHU1E metallothionein 1E [ H. sapiens ], ESTs, Moderately similar to MT1_RAT





METALLOTHIONEIN-I (MT-I) [ R. norvegicus ], metallothionein 1, metallothionein 4,





metallothionein IV

15189
803
M11794
metallothionein 1,
EST, Moderately similar to Cd-7 Metallothionein-2 [ H. sapiens ], EST, Moderately similar to
B




metallothionein 1A (functional)
SMHU1E metallothionein 1E [ H. sapiens ], ESTs, Moderately similar to MT1_RAT





METALLOTHIONEIN-I (MT-I) [ R. norvegicus ], metallothionein 1, metallothionein 4,





metallothionein IV

8984
1014
NM_022539
methionine aminopeptidase 2,
ESTs, Moderately similar to AMP2 MOUSE METHIONINE AMINOPEPTIDASE 2
D




methionyl aminopeptidase 2
[ M. musculus ], methionine aminopeptidase 2, methionyl aminopeptidase 2

9332
694
AI232210
MIC2 (monoclonal Imperial
ESTs, Weakly similar to S26689 hypothetical protein hc1 - mouse [ M. musculus ], MIC2
F




Cancer Research Fund 2)-like
like 1, expressed sequence AI893641




1, MIC2 like 1

15017
790
J03752
microsomal glutathione S-

B




transferase 1

13939
933
NM_017212
microtubule-associated protein

D




tau

13940
933
NM_017212
microtubule-associated protein

D




tau

15291
537
AI111401
multiple inositol polyphosphate

D




histidine phosphatase 1,




multiple inositol polyphosphate




histidine phosphatase, 1

2629
830
NM_012603
myelocytomatosis oncogene, v
myelocytomatosis oncogene, v-myc myelocytomatosis viral oncogene homolog (avian)
K




myc myelocytomatosis viral




oncogene homolog (avian)

1698
906
NM_017000
NAD(P)H dehydrogenase,
ESTs, Weakly similar to A34162 NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2) - rat
GENERAL, B, H, I




quinone 1
[ R. norvegicus ], NAD(P)H dehydrogenase, quinone 1, NAD(P)H dehydrogenase, quinone





2, NAD(P)H menadione oxidoreductase 2, dioxin inducible

3099
664
AI229680
NADH dehydrogenase
NADH dehydrogenase (ubiquinone) Fe—S protein 3 (30 kD) (NADH-coenzyme Q
E




(ubiquinone) Fe—S protein 3
reductase)




(30 kD) (NADH-coenzyme Q




reductase)

1597
1151
NM_053611
nuclear protein 1, p8 protein
EST, Weakly similar to P8_HUMAN P8 PROTEIN [ H. sapiens ], nuclear protein 1, p8
L




(candidate of metastasis 1)
protein (candidate of metastasis 1)

19712
994
NM_021745
nuclear receptor subfamily 1,
EST, Weakly similar to I38975 nuclear orphan receptor LXR-alpha [ H. sapiens ], ESTs,
K




group H, member 4
Moderately similar to JC4014 steroid hormone-nuclear receptor NER [ H. sapiens ],





expressed sequence AI957360, nuclear receptor subfamily 1, group H, member 4

1214
1102
NM_031741
nuclear receptor subfamily 1,
solute carrier family 2 (facilitated glucose transporter), member 5, solute carrier family 2
GENERAL, K




group H, member 4, solute
(facilitated glucose/fructose transporter), member 5




carrier family 2 (facilitated




glucose transporter), member




5, solute carrier family 2




(facilitated glucose/fructose




transporter), member 5,




synaptojanin 2 binding protein

17393
875
NM_012992
nucleophosmin (nucleolar
ESTs, Highly similar to A32915 nucleophosmin [ H. sapiens ], nucleophosmin 1
GENERAL




phosphoprotein B23,




numatrin), nucleophosmin 1

17394
875
NM_012992
nucleophosmin (nucleolar
ESTs, Highly similar to A32915 nucleophosmin [ H. sapiens ], nucleophosmin 1
GENERAL, L




phosphoprotein B23,




numatrin), nucleophosmin 1

1401
1152
NM_053616
nucleoporin 88 kD,
nucleoporin 88 kD, preimplantation protein 2
J




preimplantation protein 2

16006
344
AF062594
nucleosome assembly protein
ESTs, Highly similar to 2008109A set gene [ Rattus norvegicus ] [ R. norvegicus ], ESTs,
GENERAL




1-like 1
Highly similar to SET_HUMAN SET PROTEIN [ H. sapiens ], SET translocation, SET





translocation (myeloid leukemia-associated), nucleosome assembly protein 1-like 1

16007
344
AF062594
nucleosome assembly protein
ESTs, Highly similar to 2008109A set gene [ Rattus norvegicus ] [ R. norvegicus ], ESTs,
E




1-like 1
Highly similar to SET_HUMAN SET PROTEIN [ H. sapiens ], SET translocation, SET





translocation (myeloid leukemia-associated), nucleosome assembly protein 1-like 1

7665
429
AI030668
nucleosome assembly protein
ESTs, Highly similar to 2008109A set gene [ Rattus norvegicus ] [ R. norvegicus ], ESTs,
E




1-like 1
Highly similar to SET_HUMAN SET PROTEIN [ H. sapiens ], SET translocation, SET





translocation (myeloid leukemia-associated), nucleosome assembly protein 1-like 1

24264
876
NM_012999
paired basic amino acid
EST, Highly similar to I53282 gene PACE4 protein - rat [ R. norvegicus ], RIKEN cDNA
GENERAL




cleaving system 4, proprotein
A930029K19 gene, paired basic amino acid cleaving system 4, proprotein convertase




convertase subtilisin/kexin
subtilisin/kexin type 6




type 6

1581
955
NM_017365
PDZ and LIM domain 1 (elfin)
EST, Moderately similar to CL36_HUMAN LIM DOMAIN PROTEIN CLP-36 [ H. sapiens ],
GENERAL, A, C





ESTs, Weakly similar to PDL1_RAT PDZ and LIM domain protein 1 (LIM domain protein





CLP-36) (C-terminal LIM domain protein 1) (Elfin) [ R. norvegicus ], Mus musculus , clone





MGC: 37634 IMAGE: 4990983, mRNA, complete cds, PDZ and LIM domain 1 (elfin), PDZ





and LIM domain 3, Rattus norvegicus LIM-domain protein LMP-1 mRNA, complete cds,





actinin alpha 2 associated LIM protein

1081
1097
NM_031712
PDZ domain containing 1
ESTs, Highly similar to PDZ domain containing-protein [ H. sapiens ], PDZ domain
GENERAL, D





containing 1, natrium-phosphate cotransporter IIa C-terminal-associated protein 2,





pleckstrin homology, Sec7 and coiled/coil domains, binding protein

19998
1125
NM_033352
PDZ domain containing 1
ESTs, Highly similar to PDZ domain containing-protein [ H. sapiens ], PDZ domain
GENERAL





containing 1, natrium-phosphate cotransporter IIa C-terminal-associated protein 2,





pleckstrin homology, Sec7 and coiled/coil domains, binding protein

1650
34
AA817825
peptidylglycine alpha-
ESTs, Weakly similar to AMD MOUSE PEPTIDYL-GLYCINE ALPHA-AMIDATING
A




amidating monooxygenase
MONOOXYGENASE PRECURSOR [ M. musculus ], peptidylglycine alpha-amidating





monooxygenase

1644
121
AA891068
peptidylglycine alpha-
ESTs, Weakly similar to AMD MOUSE PEPTIDYL-GLYCINE ALPHA-AMIDATING
A, F




amidating monooxygenase
MONOOXYGENASE PRECURSOR [ M. musculus ], peptidylglycine alpha-amidating





monooxygenase

1649
518
AI103782
peptidylglycine alpha-
ESTs, Weakly similar to AMD MOUSE PEPTIDYL-GLYCINE ALPHA-AMIDATING
F




amidating monooxygenase
MONOOXYGENASE PRECURSOR [ M. musculus ], peptidylglycine alpha-amidating





monooxygenase

1651
651
AI228068
peptidylglycine alpha-
ESTs, Weakly similar to AMD MOUSE PEPTIDYL-GLYCINE ALPHA-AMIDATING
A, H




amidating monooxygenase
MONOOXYGENASE PRECURSOR [ M. musculus ], peptidylglycine alpha-amidating





monooxygenase

1652
665
AI229728
peptidylglycine alpha-
ESTs, Weakly similar to AMD MOUSE PEPTIDYL-GLYCINE ALPHA-AMIDATING
A




amidating monooxygenase
MONOOXYGENASE PRECURSOR [ M. musculus ], peptidylglycine alpha-amidating





monooxygenase

1653
719
AI233806
peptidylglycine alpha-
ESTs, Weakly similar to AMD MOUSE PEPTIDYL-GLYCINE ALPHA-AMIDATING
A




amidating monooxygenase
MONOOXYGENASE PRECURSOR [ M. musculus ], peptidylglycine alpha-amidating





monooxygenase

4392
918
NM_017101
peptidylprolyl isomerase A,
EST, Moderately similar to A Chain A, Cyclophilin A [ H. sapiens ], ESTs, Highly similar to
H




peptidylprolyl isomerase A
CYPH MOUSE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A [ M. musculus ], ESTs,




(cyclophilin A)
Moderately similar to A Chain A, Human Cyclophilin A Complexed With 2-Thr Cyclosporin





[ H. sapiens ], ESTs, Weakly similar to A Chain A, Cyclophilin A [ H. sapiens ], ESTs, Weakly





similar to A Chain A, Human Cyclophilin A Complexed With 2-Thr Cyclosporin





[ H. sapiens ], ESTs, Weakly similar to CYPH_RAT Peptidyl-prolyl cis-trans isomerase A





(PPlase) (Rotamase) (Cyclophilin A) (Cyclosporin A-binding protein) (P31)





[ R. norvegicus ], RIKEN cDNA 2510026K04 gene, expressed sequence AI256741,





expressed sequence AW457192 peptidylprolyl isomerase A

405
1081
NM_031587
peroxisomal membrane
ESTs, Weakly similar to MPV1 MOUSE MPV17 PROTEIN [ M. musculus ], MpV17
GENERAL, H, K




protein 2 (22 kD), peroxisomal
transgene, murine homolog, glomerulosclerosis, Mpv17 transgene, kidney disease




membrane protein 2, 22 kDa
mutant, peroxisomal membrane protein 2, 22 kDa

6055
831
NM_012619
phenylalanine hydroxylase
ESTs, Highly similar to WHHUF phenylalanine 4-monooxygenase [ H. sapiens ],
GENERAL, D





phenylalanine hydroxylase

15599
938
NM_017236
phosphatidylethanolamine
Homo sapiens , clone MGC: 22776 IMAGE: 4700840, mRNA, complete cds, RIKEN cDNA
J




binding protein, prostatic
1700023A18 gene, RIKEN cDNA 1700081D17 gene, phosphatidylethanolamine binding




binding protein
protein, prostatic binding protein

1340
1098
NM_031715
phosphofructokinase, muscle
ESTs, Highly similar to phosphofructokinase, muscle; phosphofructokinase-1 A isozyme
B





[ Mus musculus ] [ M. musculus ], expressed sequence AI131669, phosphofructokinase,





muscle

25377
800
L25387
phosphofructokinase, platelet

D

1312
1130
NM_053291
phosphoglycerate kinase 1
ESTs, Highly similar to A33792 phosphoglycerate kinase (EC 2.7.2.3) - rat
J





[ R. norvegicus ], phosphoglycerate kinase 1, phosphoglycerate kinase 2

20414
799
L14323
phospholipase C, beta 1,

GENERAL




phospholipase C, beta 1




(phosphoinositide-specific)

1535
331
AB000778
phospholipase D1,
EST, Highly similar to PLD1_MOUSE PHOSPHOLIPASE D1 (PLD 1) (CHOLINE
F




phospholipase D1,
PHOSPHATASE 1) (PHOSPHATIDYLCHOLINE-HYDROLYZING PHOSPHOLIPASE D1)




phophatidylcholine-specific
[ M. musculus ], phospholipase D1, phophatidylcholine-specific

24582
939
NM_017243
phosphoribosyl pyrophosphate
Mus musculus , phosphoribosyl pyrophosphate synthetase-associated protein 2, clone
D




synthetase 1
MGC: 36957 IMAGE: 4947226, mRNA, complete cds, RIKEN cDNA 5730409F23 gene,





expressed sequence C76678, phosphoribosyl pyrophosphate synthetase 1

1847
834
NM_012634
phosphoribosyl pyrophosphate
RIKEN cDNA 2610101M19 gene, phosphoribosyl pyrophosphate synthetase 2
B




synthetase 2

13369
1157
NM_053742
phosphotidylinositol transfer
ESTs, Highly similar to PPI2_HUMAN PHOSPHATIDYLINOSITOL TRANSFER
D




protein, beta
PROTEIN BETA ISOFORM [ H. sapiens ], phosphotidylinositol transfer protein, beta

20298
981
NM_019374
prodynorphin

I

24566
833
NM_012630
prolactin receptor
prolactin receptor, prolactin receptor related sequence 1
B, F, L

24567
833
NM_012630
prolactin receptor
prolactin receptor, prolactin receptor related sequence 1
F

24568
833
NM_012630
prolactin receptor
prolactin receptor, prolactin receptor related sequence 1
GENERAL, B

11454
1004
NM_022381
proliferating cell nuclear
proliferating cell nuclear antigen
GENERAL




antigen

11455
1004
NM_022381
proliferating cell nuclear
proliferating cell nuclear antigen
GENERAL




antigen

503
841
NM_012704
prostaglandin E receptor 3

C




(subtype EP3)

15470
1116
NM_031978
proteasome (prosome,
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1, proteasome (prosome,
H




macropain) 26S subunit, non-
macropain) 26S subunit, non-ATPase, 2




ATPase, 1

18750
940
NM_017257
proteasome (prosome,
expressed sequence AA589371, expressed sequence AI788882, proteasome (prosome,
G




macropain) 28 subunit, beta,
macropain) 28 subunit, beta, proteasome (prosome, macropain) activator subunit 2




proteasome (prosome,
(PA28 beta)




macropain) activator subunit 2




(PA28 beta)

18751
940
NM_017257
proteasome (prosome,
expressed sequence AA589371, expressed sequence AI788882, proteasome (prosome,
G




macropain) 28 subunit, beta,
macropain) 28 subunit, beta, proteasome (prosome, macropain) activator subunit 2




proteasome (prosome,
(PA28 beta)




macropain) activator subunit 2




(PA28 beta)

3987
943
NM_017280
proteasome (prosome,
EST, Weakly similar to SNHUC8 multicatalytic endopeptidase complex [ H. sapiens ],
GENERAL




macropain) subunit, alpha type
ESTs, Highly similar to PRC8 MOUSE PROTEASOME COMPONENT C8 [ M. musculus ],




3, proteasome (prosome,
ESTs, Weakly similar to PRC8 MOUSE PROTEASOME COMPONENT C8 [ M. musculus ],




macropain) subunit, alpha
proteasome (prosome, macropain) subunit, alpha type 3, proteasome (prosome,




type, 3
macropain) subunit, alpha type, 3

1447
944
NM_017281
proteasome (prosome,
EST, Moderately similar to PRC9_HUMAN PROTEASOME COMPONENT C9
D




macropain) subunit, alpha type
[ H. sapiens ], proteasome (prosome, macropain) subunit, alpha type 4, proteasome




4, proteasome (prosome,
(prosome, macropain) subunit, alpha type, 4




macropain) subunit, alpha




type, 4

3254
945
NM_017282
proteasome (prosome,
proteasome (prosome, macropain) subunit, alpha type 5, proteasome (prosome,
L




macropain) subunit, alpha type
macropain) subunit, alpha type, 5




5, proteasome (prosome,




macropain) subunit, alpha




type, 5

15535
946
NM_017283
proteasome (prosome,
ESTs, Highly similar to S30274 multicatalytic endopeptidase complex [ H. sapiens ], ESTs,
L




macropain) subunit, alpha type
Weakly similar to JX0230 multicatalytic endopeptidase complex (EC 3.4.99.46) iota chain -




6, proteasome (prosome,
rat [ R. norvegicus ], proteasome (prosome, macropain) subunit, alpha type 6




macropain) subunit, alpha




type, 6

15538
946
NM_017283
proteasome (prosome,
ESTs, Highly similar to S30274 multicatalytic endopeptidase complex [ H. sapiens ], ESTs,
L




macropain) subunit, alpha type
Weakly similar to JX0230 multicatalytic endopeptidase complex (EC 3.4.99.46) iota chain -




6, proteasome (prosome,
rat [ R. norvegicus ], proteasome (prosome, macropain) subunit, alpha type 6




macropain) subunit, alpha




type, 6

25253
1173
NM_057099
proteasome (prosome,
proteasome (prosome, macropain) subunit, beta type 6, proteasome (prosome,
H




macropain) subunit, beta type
macropain) subunit, beta type, 6




6, proteasome (prosome,




macropain) subunit, beta type, 6

556
851
NM_012803
protein C, protein C
B-factor, properdin, ESTs, Weakly similar to S18994 protein C (activated) (EC 3.4.21.69)
GENERAL




(inactivator of coagulation
precursor - rat [ R. norvegicus ], histocompatibility 2, complement component factor B,




factors Va and VIIIa)
protein C, protein C (inactivator of coagulation factors Va and VIIIa)

24563
1026
NM_022676
protein phosphatase 1,
EST, Weakly similar to IPP1_HUMAN PROTEIN PHOSPHATASE INHIBITOR 1
G, K




regulatory (inhibitor) subunit
[ H. sapiens ], ESTs, Moderately similar to PROTEIN PHOSPHATASE INHIBITOR 1




1A
[ R. norvegicus ], Mus musculus , clone MGC: 18770 IMAGE: 4164563, mRNA, complete





cds, RIKEN cDNA 4930565M23 gene, protein phosphatase 1 regulatory subunit 1A,





protein phosphatase 1, regulatory (inhibitor) subunit 1A

24564
1026
NM_022676
protein phosphatase 1
EST, Weakly similar to IPP1_HUMAN PROTEIN PHOSPHATASE INHIBITOR 1
G, K




regulatory (inhibitor) subunit
[ H. sapiens ], ESTs, Moderately similar to PROTEIN PHOSPHATASE INHIBITOR 1




1A
[ R. norvegicus ], Mus musculus , clone MGC: 18770 IMAGE: 4164563, mRNA, complete





cds, RIKEN cDNA 4930565M23 gene, protein phosphatase 1 regulatory subunit 1A,





protein phosphatase 1, regulatory (inhibitor) subunit 1A

24219
1079
NM_031579
protein tyrosine phosphatase
protein tyrosine phosphatase 4a1, protein tyrosine phosphatase 4a3, protein tyrosine
GENERAL, L




4a1, protein tyrosine
phosphatase type IVA, member 1, protein tyrosine phosphatase type IVA, member 3




phosphatase type IVA,




member 1

1844
835
NM_012637
protein tyrosine phosphatase,
EST, Moderately similar to A34845 protein-tyrosine-phosphatase (EC 3.1.3.48),
J




non-receptor type 1
nonreceptor type 1B - rat [ R. norvegicus ], ESTs, Moderately similar to PTN1_HUMAN





PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 [ H. sapiens ], protein





tyrosine phosphatase, non-receptor type 1

14978
622
AI177386
protein tyrosine phosphatase,
ESTs, Weakly similar to 2103274A receptor type protein Tyr phosphatase [ M. musculus ],
F




receptor type, D
RIKEN cDNA 1600019O04 gene, expressed sequence AU040377, protein tyrosine





phosphatase, receptor type, S

245
952
NM_017336
protein tyrosine phosphatase,

J




receptor type, O

247
952
NM_017336
protein tyrosine phosphatase,

J




receptor type, O

1929
1045
NM_030872
pyruvate dehydrogenase 2,
Mus musculus , Similar to pyruvate dehydrogenase kinase, isoenzyme 1, clone
A, C, D, E




pyruvate dehydrogenase
MGC: 28719 IMAGE: 4458562, mRNA, complete cds, Mus musculus , Similar to pyruvate




kinase, isoenzyme 2
dehydrogenase kinase, isoenzyme 3, clone MGC: 6383 IMAGE: 3500763, mRNA,





complete cds, pyruvate dehydrogenase 2, pyruvate dehydrogenase kinase, isoenzyme 2

20831
1147
NM_053589
RAB14, member RAS
EST, Highly similar to GTPase Rab14 [ Rattus norvegicus ] [ R. norvegicus ], ESTs, Highly
B




oncogene family
similar to F34323 GTP-binding protein Rab5 [ H. sapiens ], ESTs, Highly similar to





RB14_HUMAN RAS-RELATED PROTEIN RAB-14 [ R. norvegicus ], ESTs, Weakly similar





to RB14_HUMAN Ras-related protein Rab-14 [ R. norvegicus ], Mus musculus Rab-related





GTP-binding protein (Rabj) mRNA, complete cds, RAB14, member RAS oncogene family

6577
1011
NM_022532
raf-related oncogene, v-raf
Mus musculus adult male lung cDNA, RIKEN full-length enriched library,
F




murine sarcoma 3611 viral
clone: 1200013E08:raf-related oncogene, full insert sequence, expressed sequence




oncogene homolog 1
AW495444, raf-related oncogene, v-raf murine sarcoma 3611 viral oncogene homolog 1

4661
207
AA899709
receptor (calcitonin) activity
receptor (calcitonin) activity modifying protein 3
GENERAL, B, L




modifying protein 3

28
1077
NM_031546
regucalcin, regucalcin
regucalcin, regucalcin (senescence marker protein-30)
GENERAL, F, G, I, J, L




(senescence marker protein-




30)

23806
842
NM_012733
retinol binding protein 1,
ESTs, Weakly similar to RET1_RAT Retinol-binding protein I, cellular (Cellular retinol-
D




cellular
binding protein) (CRBP) [ R. norvegicus ], retinoid binding protein 7, retinol binding protein





1, cellular, retinol binding protein 5, cellular, retinol binding protein 7, cellular

21575
1093
NM_031698
ribophorin II
EST, Moderately similar to RIB2_HUMAN DOLICHYL-
J





DIPHOSPHOOLIGOSACCHARIDE-PROTEIN GLYCOSYLTRANSFERASE 63 KDA





SUBUNIT PRECURSOR [ H. sapiens ], ESTs, Moderately similar to RIB2_HUMAN





DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE-PROTEIN GLYCOSYLTRANSFERASE





63 KDA SUBUNIT PRECURSOR [ H. sapiens ], ribophorin 2, related sequence 1,





ribophorin II

11849
1052
NM_031065
ribosomal protein L10A,
EST, Moderately similar to R10A MOUSE 60S RIBOSOMAL PROTEIN L10A
GENERAL, G




ribosomal protein L10a
[ M. musculus ], ribosomal protein L10A, ribosomal protein L10a

19112
764
AI639157
ribosomal protein L13
EST, Moderately similar to JC2368 ribosomal protein L13, cytosolic [validated] - rat
J





[ R. norvegicus ], EST, Weakly similar to JC2368 ribosomal protein L13, cytosolic





[validated] - rat [ R. norvegicus ], ESTs, Highly similar to ribosomal protein L13; 60S





ribosomal protein L13; breast basic conserved protein 1 [ Homo sapiens ] [ H. sapiens ],





ESTs, Moderately similar to RL13 MOUSE 60S RIBOSOMAL PROTEIN L13





[ M. musculus ], Homo sapiens cDNA FLJ30941 fis, clone FEBRA2007458, Human RPL13-





2 pseudogene mRNA complete cds ribosomal protein L13

23854
1054
NM_031101
ribosomal protein L13
EST, Moderately similar to JC2368 ribosomal protein L13, cytosolic [validated] - rat
G





[ R. norvegicus ], EST, Weakly similar to JC2368 ribosomal protein L13, cytosolic





[validated] - rat [ R. norvegicus ], ESTs, Highly similar to ribosomal protein L13; 60S





ribosomal protein L13; breast basic conserved protein 1 [ Homo sapiens ] [ H. sapiens ],





ESTs, Moderately similar to RL13 MOUSE 60S RIBOSOMAL PROTEIN L13





[ M. musculus ], Homo sapiens cDNA FLJ30941 fis, clone FEBRA2007458, Human RPL13-





2 pseudogene mRNA. complete cds ribosomal protein L13

14929
1134
NM_053330
ribosomal protein L21
EST, Moderately similar to 2113200B ribosomal protein L21 [ H. sapiens ], EST,
GENERAL, G, K





Moderately similar to RL21_RAT 60S RIBOSOMAL PROTEIN L21 [ R. norvegicus ], EST,





Weakly similar to 2113200B ribosomal protein L21 [ H. sapiens ], EST, Weakly similar to





RL21 MOUSE 60S RIBOSOMAL PROTEIN L21 [ M. musculus ], EST, Weakly similar to





RL21_HUMAN 60S RIBOSOMAL PROTEIN L21 [ H. sapiens ], ESTs, Highly similar to





2113200B ribosomal protein L21 [ H. sapiens ], ESTs, Highly similar to RL21 MOUSE 60S





RIBOSOMAL PROTEIN L21 [ M. musculus ], ESTs, Moderately similar to RL21 MOUSE





60S RIBOSOMAL PROTEIN L21 [ M. musculus ], ribosomal protein L21

19268
1055
NM_031104
ribosomal protein L22
ESTs, Highly similar to 60S RIBOSOMAL PROTEIN L22 [ H. sapiens ], RIKEN cDNA
D





2700038K18 gene, RIKEN cDNA 3110001N18 gene, ribosomal protein L22

18612
658
AI228624
ribosomal protein L29
EST, Moderately similar to RL29_HUMAN 60S RIBOSOMAL PROTEIN L29 [ H. sapiens ],
G





EST, Moderately similar to RL29_RAT 60S RIBOSOMAL PROTEIN L29 (P23)





[ R. norvegicus ], ESTs, Highly similar to S65784 ribosomal protein L29, cytosolic





[ H. sapiens ], ribosomal protein L29

25718
1248
X62145
ribosomal protein L8

GENERAL, G

24615
1057
NM_031112
ribosomal protein S24
EST, Weakly similar to JH0213 ribosomal protein S24, cytosolic [ H. sapiens ], EST,
D





Weakly similar to RS24_HUMAN 40S RIBOSOMAL PROTEIN S24 [ M. musculus ], ESTs,





Highly similar to JH0213 ribosomal protein S24, cytosolic [ H. sapiens ], ribosomal protein





S24

25686
1237
X51536
ribosomal protein S3

F

25702
1244
X58465
ribosomal protein S5
EST, Moderately similar to 2113200E ribosomal protein S5 [ H. sapiens ], EST, Weakly
G





similar to 2113200E ribosomal protein S5 [ H. sapiens ], ribosomal protein S5

10109
1244
X58465
ribosomal protein S5
EST, Moderately similar to 2113200E ribosomal protein S5 [ H. sapiens ], EST, Weakly
G





similar to 2113200E ribosomal protein S5 [ H. sapiens ], ribosomal protein S5

17104
924
NM_017160
ribosomal protein S6
EST, Moderately similar to R3HU6 ribosomal protein S6, cytosolic [ H. sapiens ], EST,
GENERAL, G





Moderately similar to RS6_HUMAN 40S RIBOSOMAL PROTEIN S6 [ H. sapiens ], EST,





Weakly similar to R3HU6 ribosomal protein S6, cytosolic [ H. sapiens ], ESTs, Highly





similar to RS6_HUMAN 40S RIBOSOMAL PROTEIN S6 [ H. sapiens ], ESTs, Weakly





similar to RS6_HUMAN 40S RIBOSOMAL PROTEIN S6 [ H. sapiens ], ribosomal protein





S6

16204
1096
NM_031706
ribosomal protein S8
EST, Weakly similar to 40S RIBOSOMAL PROTEIN S8 [ M. musculus ], ESTs, Highly
GENERAL, G





similar to S25022 ribosomal protein S8, cytosolic [ H. sapiens ], ESTs, Moderately similar





to RS8_HUMAN 40S RIBOSOMAL PROTEIN S [ H. sapiens ], RIKEN cDNA 1110008P08





gene, ribosomal protein S8

16205
1096
NM_031706
ribosomal protein S8
EST, Weakly similar to 40S RIBOSOMAL PROTEIN S8 [ M. musculus ], ESTs, Highly
F





similar to S25022 ribosomal protein S8, cytosolic [ H. sapiens ], ESTs, Moderately similar





to RS8_HUMAN 40S RIBOSOMAL PROTEIN S [ H. sapiens ], RIKEN cDNA 1110008P08





gene, ribosomal protein S8

1382
332
AB002406
RuvB-like 1 ( E. coli ), RuvB-like
Homer, neuronal immediate early gene, 1B, homer, neuronal immediate early gene, 1
G




protein 1

19040
1058
NM_031114
S100 calcium binding protein
EST, Moderately similar to S110_RAT Calpactin I light chain (P10 protein) (P11) (Cellular
GENERAL, C, G, K




A10 (annexin II ligand,
ligand of annexin II) (Nerve growth factor induced protein 42C) [ R. norvegicus ], S100




calpactin I, light polypeptide
calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)), S100




(p11)), S100 calcium binding
calcium binding protein A10 (calpactin)




protein A10 (calpactin)

16394
1140
NM_053485
S100 calcium binding protein

K




A6 (calcyclin)

16318
678
AI230724
SAC1 (supressor of actin

GENERAL, I




mutations 1, homolog)-like ( S. cerevisiae ),




SAC1 suppressor




of actin mutations 1-like




(yeast)

23651
862
NM_012881
secreted phosphoprotein 1,

GENERAL, G, K




secreted phosphoprotein 1




(osteopontin, bone sialoprotein




I, early T-lymphocyte




activation 1)

4280
672
AI230247
selenoprotein P, plasma, 1
selenoprotein P, plasma, 1
F

21400
811
M36410
sepiapterin reductase,
ESTs, Highly similar to A36024 sepiapterin reductase (EC 1.1.1.153) - rat [ R. norvegicus ],
C, F




sepiapterin reductase (7,8-
sepiapterin reductase, sepiapterin reductase (7,8-dihydrobiopterin: NADP+




dihydrobiopterin: NADP+
oxidoreductase)




oxidoreductase)

15540
832
NM_012620
serine (or cysteine) proteinase

K




inhibitor, clade E (nexin,




plasminogen activator inhibitor




type 1), member 1

17301
926
NM_017173
serine (or cysteine) proteinase
serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1,
E, I




inhibitor, clade H (heat shock
serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1,




protein 47), member 1, serine
(collagen binding protein 1), serine (or cysteine) proteinase inhibitor, clade H (heat shock




(or cysteine) proteinase
protein 47), member 2




inhibitor, clade H (heat shock




protein 47), member 1,




(collagen binding protein 1)

20449
1074
NM_031530
small inducible cytokine A2,
EST, Weakly similar to S07723 immediate-early serum-responsive protein JE precursor -
GENERAL




small inducible cytokine A2
rat [ R. norvegicus ], expressed sequence AI323594, small inducible cytokine A2, small




(monocyte chemotactic protein
inducible cytokine A24, small inducible cytokine subfamily A (Cys—Cys), member 24




1)

21145
339
AF038571
solute carrier family 1
ESTs, Weakly similar to EAA3_RAT Excitatory amino acid transporter 3 (Sodium-
GENERAL, B




(neuronal/epithelial high
dependent glutamate/aspartate transporter 3) (Excitatory amino-acid carrier 1)




affinity glutamate transporter,
[ R. norvegicus ], Mus musculus adult male testis cDNA, RIKEN full-length enriched library,




system Xag), member 1,
clone: 4931413K05:solute carrier family 1, member 1, full insert sequence, Rattus




solute carrier family 1,
norvegicus mRNA for sodium-dependent neutral amino acid transporter, ASCT2, solute




member 1
carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag),





member 1, solute carrier family 1, member 1, solute carrier family 1, member 7

21147
784
D63772
solute carrier family 1
ESTs, Weakly similar to EAA3_RAT Excitatory amino acid transporter 3 (Sodium-
GENERAL, F, H, I, J, L




(neuronal/epithelial high
dependent glutamate/aspartate transporter 3) (Excitatory amino-acid carrier 1)




affinity glutamate transporter,
[ R. norvegicus ], Mus musculus adult male testis cDNA, RIKEN full-length enriched library,




system Xag), member 1,
clone: 4931413K05:solute carrier family 1, member 1, full insert sequence, Rattus




solute carrier family 1,
norvegicus mRNA for sodium-dependent neutral amino acid transporter, ASCT2, solute




member 1
carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag),





member 1, solute carrier family 1, member 1, solute carrier family 1, member 7

645
977
NM_019345
solute carrier family 12
ESTs, Moderately similar to Na+/K+/Cl−-cotransport protein renal splice form F
G, K




(sodium/chloride transporters),
[ M. musculus ], solute carrier family 12 (sodium/chloride transporters), member 3, solute




member 3, solute carrier
carrier family 12, member 3




family 12, member 3

646
977
NM_019345
solute carrier family 12
ESTs, Moderately similar to Na+/K+/Cl−-cotransport protein renal splice form F
G, K




(sodium/chloride transporters),
[ M. musculus ], solute carrier family 12 (sodium/chloride transporters), member 3, solute




member 3, solute carrier
carrier family 12, member 3




family 12, member 3

4532
958
NM_019134
solute carrier family 12
EST, Weakly similar to NKC2_HUMAN BUMETANIDE-SENSITIVE SODIUM-
J




(sodium/potassium/chloride
(POTASSIUM)-CHLORIDE COTRANSPORTER 2 (KIDNEY-SPECIFIC NA-K-CL




transporters), member 1,
SYMPORTER) [ H. sapiens ], ESTs, Moderately similar to Na+/K+/Cl−-cotransport protein




solute carrier family 12,
renal splice form F [ M. musculus ], solute carrier family 12 (potassium/chloride




member 1
transporters), member 8, solute carrier family 12 (sodium/potassium/chloride





transporters), member 1, solute carrier family 12, member 1

235
978
NM_019347
solute carrier family 14 (urea
solute carrier family 14 (urea transporter), member 2
C




transporter), member 2

15039
1090
NM_031672
solute carrier family 15

GENERAL, F, I




(H+/peptide transporter),




member 2

24770
919
NM_017111
solute carrier family 21
solute carrier family 21 (organic anion transporter), member 1, solute carrier family 21
GENERAL, G, I, J




(organic anion transporter),
(organic anion transporter), member 12, solute carrier family 21 (organic anion




member 1
transporter), member 3, solute carrier family 21 (organic anion transporter), member 6

1510
937
NM_017224
solute carrier family 22
Homo sapiens , Similar to ust3, clone MGC: 23972 IMAGE: 4714598, mRNA, complete
GENERAL, D, K




(organic anion transporter),
cds, Mus musculus , Similar to solute carrier family 22 (organic anion transporter),




member 6
member 7, clone MGC: 18877 IMAGE: 4236556, mRNA, complete cds, Rattus norvegicus





mRNA for organic anion transporter 5, complete cds, expressed sequence AI648912,





putative integral membrane transport UST1r, solute carrier family 22 (organic anion





transporter), member 6, solute carrier family 22 (organic cation transporter)-like 2, ust3

770
1080
NM_031584
solute carrier family 22
Mus musculus , clone MGC: 29260 IMAGE: 5064542, mRNA, complete cds, SV2 related
GENERAL




(organic cation transporter),
protein, solute carrier family 22 (organic cation transporter), member 2




member 2

23625
969
NM_019269
solute carrier family 22
ESTs, Weakly similar to solute carrier family 22 (organic cation transporter), member 5;
D




(organic cation transporter),
Lstp-like [ Mus musculus ] [ M. musculus ], ESTs, Weakly similar to OCN2 MOUSE




member 5
ORGANIC CATION/CARNITINE TRANSPORTER 2 [ M. musculus ], Homo sapiens





OAT4L mRNA for organic anion transpoter 4 like protein, complete cds, Mus musculus ,





Similar to solute carrier family 22 (organic cation transporter)-like 2, clone MGC: 25980





IMAGE: 4242162, mRNA, complete cds, RIKEN cDNA 4921504E14 gene, expressed





sequence AI987855, solute carrier family 22 (organic anion/cation transporter), member





11, solute carrier family 22 (organic cation transporter), member 5, solute carrier family





22 (organic cation transporter) member 9

18074
1100
NM_031738
solute carrier family 29

K




(nucleoside transporters),




member 2

1511
1137
NM_053424
solute carrier family 4 (anion
ESTs, Weakly similar to T14031 sodium bicarbonate cotransporter, pancreatic - mouse
D




exchanger), member 4, solute
[ M. musculus ], solute carrier family 4 (anion exchanger), member 4, solute carrier family




carrier family 4, sodium
4, sodium bicarbonate cotransporter, member 4, solute carrier family 4, sodium




bicarbonate cotransporter,
bicarbonate cotransporter, member 5




member 4

24496
837
NM_012654
solute carrier family 9
ESTs, Weakly similar to B40204 Na+/H+-exchanging protein 3 - rat [ R. norvegicus ],
GENERAL, I, K




(sodium/hydrogen exchanger),
ESTs, Weakly similar to NAH1 MOUSE SODIUM/HYDROGEN EXCHANGER 1




isoform 3, solute carrier family
[ M. musculus ], Mus musculus Na—H exchanger isoform NHE8 mRNA, complete cds,




9 (sodium/hydrogen
RIKEN cDNA 0610040A22 gene, RIKEN cDNA 6430709P13 gene, expressed sequence




exchanger), member 3
AI182282, expressed sequence AI930210, solute carrier family 9 (sodium/hydrogen





exchanger), isoform 6, solute carrier family 9 (sodium/hydrogen exchanger), member 1

605
935
NM_017221
sonic hedgehog homolog
ESTs, Highly similar to SHH MOUSE SONIC HEDGEHOG PROTEIN PRECURSOR
C




( Drosophila ), sonic hedgehog
[ M. musculus ], Indian hedgehog homolog, ( Drosophila ), desert hedgehog homolog,




homolog, ( Drosophila )
( Drosophila ), sonic hedgehog homolog ( Drosophila ), sonic hedgehog homolog,





( Drosophila )

1877
911
NM_017052
sorbitol dehydrogenase,
ESTs, Highly similar to A54674 L-iditol 2-dehydrogenase [ H. sapiens ], sorbitol
A, D, E




sorbitol dehydrogenase 1
dehydrogenase, sorbitol dehydrogenase 1

16681
920
NM_017136
squalene epoxidase
Homo sapiens cDNA FLJ30795 fis, clone FEBRA2001124, squalene epoxidase
B, L

15393
581
AI170663
sterol regulatory element
sterol regulatory element binding factor 1, sterol regulatory element binding factor 2,
J




binding transcription factor 2
sterol regulatory element binding transcription factor 2

24321
698
AI232340
stromal cell derived factor 1,

GENERAL, K, L




stromal cell-derived factor 1

17514
232
AA925554
succinate dehydrogenase
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
E, G




complex, subunit A,




flavoprotein (Fp)

4749
1110
NM_031834
sulfotransferase family 1A,
Aryl sulfotransferase cytosolic, 1A, phenol-preferring, member 3, RIKEN cDNA
L




phenol-preferring, member 1,
1110030E23 gene, sulfotransferase family 1A, phenol-preferring, member 1,




sulfotransferase family,
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, sulfotransferase




cytosolic, 1A, phenol-
family, cytosolic, 1A, phenol-preferring, member 2




preferring, member 1

20876
910
NM_017050
superoxide dismutase 1,
EST, Weakly similar to SODC MOUSE SUPEROXIDE DISMUTASE [ M. musculus ],
J




soluble, superoxide dismutase
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))




1, soluble (amyotrophic lateral




sclerosis 1 (adult))

494
861
NM_012880
superoxide dismutase 3,
superoxide dismutase 3, extracellular
J




extracellular

495
861
NM_012880
superoxide dismutase 3,
superoxide dismutase 3, extracellular
J




extracellular

24821
1158
NM_053788
syntaxin 1A (brain)
syntaxin 1A (brain)
J

7489
963
NM_019169
synuclein, alpha, synuclein,
synuclein, alpha, synuclein, alpha (non A4 component of amyloid precursor)
GENERAL, G, I, J, L




alpha (non A4 component of




amyloid precursor)

19031
928
NM_017180
T-cell death associated gene,
ESTs, Weakly similar to S58222 PQ-rich protein [ H. sapiens ], T-cell death associated
GENERAL, L




pleckstrin homology-like
gene, pleckstrin homology-like domain, family A, member 1, pleckstrin homology-like




domain, family A, member 1
domain, family A, member 3, tumor suppressing subtransferable candidate 3, tumor-





suppressing subchromosomal transferable fragment 3

3407
322
AA997953
TCF3 (E2A) fusion partner,
TCF3 (E2A) fusion partner, TCF3 (E2A) fusion partner (in childhood Leukemia)
F




TCF3 (E2A) fusion partner (in




childhood Leukemia)

15662
1065
NM_031318
t-complex testis expressed 1, t-
Homo sapiens , Similar to RIKEN cDNA 0610012D17 gene, clone MGC: 33212
G




complex-associated-testis-
IMAGE: 4830500, mRNA, complete cds, RIKEN cDNA 2310075M16 gene, t-complex




expressed 1-like 1
testis expressed 1, t-complex-associated-testis-expressed 1-like, t-complex-associated-





testis-expressed 1-like 1

15663
1065
NM_031318
t-complex testis expressed 1, t-
Homo sapiens , Similar to RIKEN cDNA 0610012D17 gene, clone MGC: 33212
GENERAL




complex-associated-testis-
IMAGE: 4830500, mRNA, complete cds, RIKEN cDNA 2310075M16 gene, t-complex




expressed 1-like 1
testis expressed 1, t-complex-associated-testis-expressed 1-like, t-complex-associated-





testis expressed 1-like 1

24234
1086
NM_031614
thioredoxin reductase 1
thioredoxin reductase 1, thioredoxin reductase 2
GENERAL, A, I

24235
1086
NM_031614
thioredoxin reductase 1
thioredoxin reductase 1, thioredoxin reductase 2
GENERAL, H, I

21122
1242
X56228
thiosulfate sulfurtransferase
mercaptopyruvate sulfurtransferase, thiosulfate sulfurtransferase (rhodanese), thiosulfate
E




(rhodanese), thiosulfate
sulfurtransferase, mitochondrial




sulfurtransferase,




mitochondrial

21123
1242
X56228
thiosulfate sulfurtransferase
mercaptopyruvate sulfurtransferase, thiosulfate sulfurtransferase (rhodanese), thiosulfate
D




(rhodanese), thiosulfate
sulfurtransferase, mitochondrial




sulfurtransferase,




mitochondrial

12031
201
AA893860
threonyl-tRNA synthetase
threonyl-tRNA synthetase
GENERAL, I

16871
863
NM_012887
thymopoietin
ESTs, Highly similar to THPA_HUMAN THYMOPOIETIN ALPHA [ H. sapiens ], RIKEN
E





cDNA 5630400D24 gene, thymopoietin

20816
990
NM_021261
thymosin, beta 10

GENERAL, G, K

17234
507
AI102741
tissue inhibitor of
tissue inhibitor of metalloproteinase 3, tissue inhibitor of metalloproteinase 3 (Sorsby
J




metalloproteinase 3, tissue
fundus dystrophy, pseudoinflammatory)




inhibitor of metalloproteinase 3




(Sorsby fundus dystrophy,




pseudoinflammatory)

23778
209
AA899854
topoisomerase (DNA) II alpha,
ESTs, Moderately similar to A40493 DNA topoisomerase [ H. sapiens ], ESTs, Weakly
E




topoisomerase (DNA) II alpha
similar to topoisomerase (DNA) II alpha [ Rattus norvegicus ] [ R. norvegicus ],




(170 kD)
topoisomerase (DNA) II alpha, topoisomerase (DNA) II beta

23780
1001
NM_022183
topoisomerase (DNA) II alpha,
ESTs, Moderately similar to A40493 DNA topoisomerase [ H. sapiens ], ESTs, Weakly
E




topoisomerase (DNA) II alpha
similar to topoisomerase (DNA) II alpha [ Rattus norvegicus ] [ R. norvegicus ],




(170 kD)
topoisomerase (DNA) II alpha, topoisomerase (DNA) II beta

1885
888
NM_013103
transcription factor 2,
transcription factor 2, transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor
GENERAL




transcription factor 2, hepatic;




LF-B3; variant hepatic nuclear




factor

24843
880
NM_013042
trefoil factor 3 (intestinal),

J




trefoil factor 3, intestinal

457
813
M60666
tropomyosin 1 (alpha),
Homo sapiens cDNA FLJ30635 fis, clone CTONG2002520, expressed sequence
E, G, K




tropomyosin 1, alpha
AI854628, expressed sequence C76867, tropomyosin 4, tuftelin 1

455
957
NM_019131
tropomyosin 1 (alpha),
Homo sapiens cDNA FLJ30635 fis, clone CTONG2002520, expressed sequence
E




tropomyosin 1, alpha
AI854628, expressed sequence C76867, tropomyosin 4, tuftelin 1

16684
882
NM_013052
tyrosine 3-
ESTs, Highly similar to 143F MOUSE 14-3-3 PROTEIN ETA [ M. musculus ], tyrosine 3-
GENERAL




monooxygenase/tryptophan 5-
monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide,




monooxygenase activation
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma




protein, eta polypeptide
polypeptide

25279
877
NM_013011
tyrosine 3-
ESTs, Highly similar to A Chain A, 14-3-3 ZetaPHOSPHOPEPTIDE COMPLEX
C




monooxygenase/tryptophan 5-
[ H. sapiens ], tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,




monooxygenase activation
zeta polypeptide




protein, zeta polypeptide

15050
520
AI103911
ubiquinol-cytochrome c
EST, Weakly similar to UCRI_HUMAN UBIQUINOL-CYTOCHROME C REDUCTASE
I




reductase, Rieske iron-sulfur
IRON-SULFUR SUBUNIT, MITOCHONDRIAL PRECURSOR [ H. sapiens ], ESTs,




polypeptide 1
Moderately similar to UCRI_HUMAN UBIQUINOL-CYTOCHROME C REDUCTASE





IRON-SULFUR SUBUNIT, MITOCHONDRIAL PRECURSOR [ H. sapiens ], RIKEN cDNA





4430402G14 gene, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

15124
1175
NM_057105
UDP glycosyltransferase 1
UDP glycosyltransferase 1 family, polypeptide A6, UDP glycosyltransferase 1 family,
B




family, polypeptide A cluster,
polypeptide A8




UDP glycosyltransferase 1




family, polypeptide A6, UDP-




glucuronosyltransferase 1




family, member 1

15125
1175
NM_057105
UDP glycosyltransferase 1
UDP glycosyltransferase 1 family, polypeptide A6, UDP glycosyltransferase 1 family,
B




family, polypeptide A6
polypeptide A8

10241
1101
NM_031740
UDP-Gal:betaGlcNAc beta 1,4-
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, UDP-
C, K




galactosyltransferase,
Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2, UDP-Gal:betaGlcNAc




polypeptide 6, UDP-
beta 1,4-galactosyltransferase, polypeptide 5, UDP-Gal:betaGlcNAc beta 1,4-




Gal:betaGlcNAc beta 1,4-
galactosyltransferase, polypeptide 6, UDP-Gal:betaGlcNAc beta 1,4-




galactosyltransferase,
galactosyltransferase, polypeptide 3, UDP-Gal:betaGlcNAc beta 1,4-




polypeptide 6
galactosyltransferase, polypeptide 5, UDP-Gal:betaGlcNAc beta 1,4-





galactosyltransferase, polypeptide 6

20443
982
NM_019379
vesicle docking protein p115,
vesicle docking protein p115, vesicle docking protein, 115 kDa
H




vesicle docking protein, 115 kDa

21975
923
NM_017154
xanthene dehydrogenase,

B, L




xanthine dehydrogenase

17695
704
AI232784

2,4-dienoyl CoA reductase 1, mitochondrial, 2,4-dienoyl CoA reductase 2, peroxisomal, 2-
E





4-dienoyl-Coenzyme A reductase 2, peroxisomal, Mus musculus , clone MGC: 6971





IMAGE: 3154595, mRNA, complete cds, RIKEN cDNA 0610039E24 gene, dicarbonyl/L-





xylulose reductase, hydroxysteroid (17-beta) dehydrogenase 8, hypothetical protein





BC014057, oxidoreductase UCPA, putative peroxisomal 2,4-dienoyl-CoA reductase

3279
512
AI103224

2,4-dienoyl CoA reductase 1, mitochondrial, 2,4-dienoyl CoA reductase 2, peroxisomal, 2-
F





4-dienoyl-Coenzyme A reductase 2, peroxisomal, RIKEN cDNA 5430405K24 gene,





putative peroxisomal 2,4-dienoyl-CoA reductase

4462
105
AA866264

20 alpha-hydroxysteroid dehydrogenase, ESTs, Weakly similar to DHBX MOUSE
GENERAL, A, C, I





ESTRADIOL 17 BETA-DEHYDROGENASE, A-SPECIFIC [ M. musculus ], aldo-keto





reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-





hydroxysteroid dehydrogenase), aldo-keto reductase family 1, member C2 (dihydrodiol





dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type





III), aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase,





type II), aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha





hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4), expressed





sequence AW146047

4463
135
AA891831

20 alpha-hydroxysteroid dehydrogenase, ESTs, Weakly similar to DHBX MOUSE
GENERAL, A, I





ESTRADIOL 17 BETA-DEHYDROGENASE, A-SPECIFIC [ M. musculus ], aldo-keto





reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-





hydroxysteroid dehydrogenase), aldo-keto reductase family 1, member C2 (dihydrodiol





dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type





III), aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase,





type II), aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha





hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4), expressed





sequence AW146047

21950
412
AI013861

3-hydroxyisobutyrate dehydrogenase, ESTs, Highly similar to D3HI_HUMAN 3-
G





HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR





(HIBADH) [ H. sapiens ], RIKEN cDNA 3930401K13 gene

22537
175
AA892799

3-phosphoglycerate dehydrogenase, EST, Moderately similar to SERA MOUSE D-3-
GENERAL, A, D





PHOSPHOGLYCERATE DEHYDROGENASE [ M. musculus ], Mus musculus adult male





testis cDNA, RIKEN full-length enriched library, clone: 4930404C15:3-phosphoglycerate





dehydrogenase, full insert sequence, glyoxylate reductase/hydroxypyruvate reductase,





phosphoglycerate dehydrogenase

22538
175
AA892799

3-phosphoglycerate dehydrogenase, EST, Moderately similar to SERA MOUSE D-3-
GENERAL, D





PHOSPHOGLYCERATE DEHYDROGENASE [ M. musculus ], Mus musculus adult male





testis cDNA, RIKEN full-length enriched library, clone: 4930404C15:3-phosphoglycerate





dehydrogenase, full insert sequence, glyoxylate reductase/hydroxypyruvate reductase,





phosphoglycerate dehydrogenase

22539
175
AA892799

3-phosphoglycerate dehydrogenase, EST, Moderately similar to SERA MOUSE D-3-
GENERAL





PHOSPHOGLYCERATE DEHYDROGENASE [ M. musculus ], Mus musculus adult male





testis cDNA, RIKEN full-length enriched library, clone: 4930404C15:3-phosphoglycerate





dehydrogenase, full insert sequence, glyoxylate reductase/hydroxypyruvate reductase,





phosphoglycerate dehydrogenase

22540
221
AA924630

3-phosphoglycerate dehydrogenase, EST, Moderately similar to SERA MOUSE D-3-
E





PHOSPHOGLYCERATE DEHYDROGENASE [ M. musculus ], Mus musculus adult male





testis cDNA, RIKEN full-length enriched library, clone: 4930404C15:3-phosphoglycerate





dehydrogenase, full insert sequence, glyoxylate reductase/hydroxypyruvate reductase,





phosphoglycerate dehydrogenase

13485
989
NM_020306

a disintegrin and metalloproteinase domain 17, a disintegrin and metalloproteinase
B





domain 17 (tumor necrosis factor, alpha, converting enzyme)

347
1205
U01914

A kinase (PRKA) anchor protein 8, ESTs, Weakly similar to A53414 A-kinase anchor
D





protein 95, AKAP9S - rat [ R. norvegicus ], Mus musculus 10 days embryo whole body





cDNA, RIKEN full-length enriched library, clone: 2610301A12:neighbor of A-kinase





anchoring protein 95, full insert sequence, expressed sequence AI467606, neighbor of A-





kinase anchoring protein 95, zinc finger protein 326

17516
950
NM_017321

aconitase 1, aconitase 1, soluble
A, E, L

23758
285
AA956414

acyl-Coenzyme A dehydrogenase family, member 8, hypothetical protein FLJ12592,
C, G





hypothetical protein MGC5601

21696
1034
NM_024152

ADP-ribosylation factor 6, ESTs, Weakly similar to ARF6_HUMAN ADP-RIBOSYLATION
C





FACTOR 6 [ M. musculus ], ESTs, Weakly similar to ARF6_HUMAN ADP-ribosylation





factor 6 [ R. norvegicus ], RIKEN cDNA 1110033P22 gene, RIKEN cDNA 2310075M17





gene, RIKEN cDNA 9130014L17 gene, SAR1 protein, SAR1a gene homolog ( S. cerevisiae ),





hypothetical protein FLJ22595

11968
597
AI172208

Alpha-fetoprotein, alpha fetoprotein, alpha-fetoprotein
F

24648
1046
NM_030985

angiotensin receptor 1
GENERAL

16649
891
NM_013132

annexin A5
GENERAL, E

16650
891
NM_013132

annexin A5
E

21462
77
AA851261

ART-4 protein
GENERAL, J

5867
85
AA858953

asparaginyl-tRNA synthetase, hypothetical protein FLJ23441
GENERAL

18449
1204
U00926

ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, EST,
H





Moderately similar to ATPD_HUMAN ATP SYNTHASE DELTA CHAIN,





MITOCHONDRIAL PRECURSO [ H. sapiens ], RIKEN cDNA 0610008F14 gene, RIKEN





cDNA 1500000I11 gene, expressed sequence AI467246

16907
35
AA817977

ATPase, H+ transporting, lysosomal 42 kD, V1 subunit C, isoform 1, RIKEN cDNA
C





1110038G14 gene

22662
725
AI234939

ATPase, H+ transporting, lysosomal interacting protein 1, EST, Weakly similar to I54197
GENERAL





hypothetical protein [ H. sapiens ], ESTs, Weakly similar to VAS1_RAT Vacuolar ATP





synthase subunit S1 precursor (V-ATPase S1 subunit) (V-ATPase S1 accessory protein)





(V-ATPase Ac45 subunit) (C7-1 protein) [ R. norvegicus ], Homo sapiens cDNA FLJ12563





fis, clone NT2RM4000820, weakly similar to VACUOLAR ATP SYNTHASE SUBUNIT





AC45 PRECURSOR (EC 3.6.1.34), expressed sequence AW108110

20841
1084
NM_031604

ATPase, H+ transporting, lysosomal V0 subunit A isoform 4, ATPase, H+ transporting,
H





lysosomal V0 subunit a isoform 1, ATPase, H+ transporting, lysosomal V0 subunit a





isoform 2, ATPase, H+ transporting, lysosomal V0 subunit a isoform 4, EST, Weakly





similar to B38656 vacuolar proton pump 116K chain - rat [ R. norvegicus ], ESTs,





Moderately similar to B38656 vacuolar proton pump 116K chain - rat [ R. norvegicus ]

9176
490
AI072675

ATP-dependant interferon responsive, Mus musculus , clone IMAGE: 4952483, mRNA,
A





partial cds, Mus musculus , clone MGC: 18883 IMAGE: 4238480, mRNA, complete cds,





dystonia 1, torsion (autosomal dominant; torsin A), torsin family 2, member A, torsin





family 3, member A

20582
93
AA859688

AU RNA binding protein/enoyl-Coenzyme A hydratase, AU RNA binding protein/enoyl-
A, E, F, K





coenzyme A hydratase, ESTs, Weakly similar to I37195 AU-specific RNA-binding protein/





enoyl-CoA hydratase homolog [ H. sapiens ], Mus musculus , Similar to 3-





hydroxyisobutyryl-Coenzyme A hydrolase, clone MGC: 31364 IMAGE: 4238681, mRNA,





complete cds, RIKEN cDNA 1300017C12 gene, uncharacterized hypothalamus protein





HCDASE

23679
974
NM_019290

B-cell translocation gene 3, BTG family, member 3
C, L

23033
1188
NM_080888

BCL2/adenovirus E1B 19 kDa-interacting protein 3-like, BCL2/adenovirus E1B 19 kD
A, C, K





interacting protein 3-like

21632
359
AI009167

BCL2-associated athanogene 2
GENERAL, H, I

15171
690
AI231792

BCL2-associated athanogene 3, BCL2-associated athanogene 5, Bcl2-associated
H





athanogene 3, RIKEN cDNA 1700081D05 gene

17824
54
AA819362

beta-site APP-cleaving enzyme, hypothetical protein MGC7474
A

17823
76
AA851214

beta-site APP-cleaving enzyme, hypothetical protein MGC7474
D

1888
1177
NM_057130

BH3 interacting (with BCL2 family) domain, apoptosis agonist, ESTs, Weakly similar to
B





HRK MOUSE ACTIVATOR OF APOPTOSIS HARAKIRI [ M. musculus ], harakiri, BCL2





interacting protein (contains only BH3 domain)

23957
291
AA957123

brain expressed, X-linked 1, hypothetical protein FLJ10097
GENERAL

17836
198
AA893626

BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast), Guanine nucleotide-
D





binding protein beta 1, RIKEN cDNA 2700038L12 gene, budding uninhibited by





benzimidazoles 3 homolog ( S. cerevisiae ), neural precursor cell expressed,





developmentally down-regulated gene 1

17550
387
AI011607

butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase)
GENERAL, I





1, butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine





hydroxylase), epsilon-trimethyllysine 2-oxoglutarate dioxygenase, gamma-butyrobetaine





hydroxylase

17249
137
AA891858

cadherin 16, cadherin 16, KSP-cadherin, cadherin 17, cadherin 17, LI cadherin (liver-
K





intestine)

24672
810
M34097

cathepsin G, granzyme B, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated
C





serine esterase 1), granzyme C, similar to granzyme B (granzyme 2, cytotoxic T-





lymphocyte-associated serine esterase 1) (H. sapiens)

1894
949
NM_017320

cathepsin S
B, L

6635
68
AA849786

CDC-like kinase 2, CDC-like kinase 3, EST, Highly similar to CLK3_RAT Protein kinase
GENERAL





CLK3 (CDC-like kinase 3) [ R. norvegicus ], ESTs, Weakly similar to CLK3_RAT Protein





kinase CLK3 (CDC-like kinase 3) [ R. norvegicus ]

15237
773
AI639535

CDw92 antigen, ESTs, Weakly similar to CTL2 gene [ Homo sapiens ] [ H. sapiens ], Homo
J





sapiens , clone MGC: 34032 IMAGE: 4828797, mRNA, complete cds, Mus musculus ,





Similar to transporter-like protein, clone MGC: 7894 IMAGE: 3582543, mRNA, complete





cds, RIKEN cDNA 1110028E10 gene, RIKEN cDNA 2210409B01 gene, chromosome 6





open reading frame 29, expressed sequence AW547365, transporter-like protein

21651
975
NM_019296

cell division cycle 2 homolog A ( S. pombe ), cell division cycle 2, G1 to S and G2 to M,
E





cyclin-dependent kinase-like 1 (CDC2-related kinase)

12716
372
AI010178

CGI-100 protein
GENERAL

3121
353
AI008160

CGI-83 protein
GENERAL, G, K

8944
466
AI070597

CGI-97 protein, EST, Weakly similar to YC97_HUMAN HYPOTHETICAL PROTEIN CGI-
F





97 [ H. sapiens ]

17154
1161
NM_053835

clathrin, light polypeptide (Lca), clathrin, light polypeptide (Lcb), expressed sequence
J





AV026556

108
797
L14002

CMRF35 leukocyte immunoglobulin-like receptor, EST, Weakly similar to PIGR_RAT
J





Polymeric-immunoglobulin receptor precursor (Poly-IG receptor) (PIGR) [Contains:





Secretory component] [ R. norvegicus ], Fc receptor, IgA, IgM, high affinity, Homo sapiens ,





similar to CMRF35 ANTIGEN PRECURSOR, clone MGC: 26887 IMAGE: 4827737,





mRNA, complete cds, Mus musculus polymeric immunoglobulin receptor 3 precursor





(Pigr3) mRNA, complete cds, RIKEN cDNA 1810037B05 gene, RIKEN cDNA





2310016B05 gene, immunoglobulin superfamily, member 7, polymeric immunoglobulin





receptor regulator of Fas-induced apoptosis

2782
326
AA998565

cyclin-dependent kinase inhibitor 1C (P57), cyclin-dependent kinase inhibitor 1C (p57,
J





Kip2)

19003
1189
NM_080903

cystatin and DUF19 domain containing 1, ret finger protein 2, ring finger protein 28, ring
F





finger protein 29, ring finger protein 30, tripartite motif protein 13

4327
1144
NM_053563

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, DEAD/H (Asp-Glu-Ala-Asp/His) box
GENERAL, G, I





polypeptide 20, 103 kD, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39, DEAD/H





(Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54 kD), DEAD/H (Asp-Glu-Ala-





Asp/His) box polypeptide 7 (RNA helicase, 52 kD), EST, Moderately similar to HLA-B-





associated transcript 1A; DNA segment, Chr 17, human D6S81E 1; nuclear RNA helicase





Bat1 [ Mus musculus ] [ M. musculus ], HLA-B-associated transcript 1A

24459
1183
NM_057209

death-associated kinase 3, expressed sequence AI120141, myosin light chain kinase 2,
C





skeletal muscle

22612
262
AA945624

Diaphorase (NADH/NADPH), EST, Weakly similar to A32667 NAD(P)H dehydrogenase
GENERAL, I





[ H. sapiens ], NAD(P)H dehydrogenase, quinone 1, NAD(P)H dehydrogenase, quinone 2,





NAD(P)H menadione oxidoreductase 2, dioxin inducible

4504
1035
NM_024159

disabled homolog 1 ( Drosophila ), disabled homolog 2 ( Drosophila ), disabled homolog 2,
D





mitogen-responsive phosphoprotein ( Drosophila )

14267
389
AI011738

DKFZP564B167 protein, RIKEN cDNA 2010002I07 gene, RIKEN cDNA 2610205H19
A





gene

4360
785
H31813

DKFZP586B1621 protein
GENERAL, G, I

3834
629
AI177902

DKFZP586F1524 protein
G

1949
1212
U19614

DKFZP586G011 protein, ESTs, Moderately similar to I61730 lamina associated
A





polypeptide 1C short splice form - rat [ R. norvegicus ], ESTs, Weakly similar to I61730





lamina associated polypeptide 1C short splice form - rat [ R. norvegicus ], ESTs, Weakly





similar to T08767 probable lamina-associated protein DKFZp586G011.1 [ H. sapiens ],





Homo sapiens , clone IMAGE: 4651703, mRNA, Mus musculus , clone MGC: 6357





IMAGE: 3493883, mRNA, complete cds

7307
736
AI235935

DKFZP586G1517 protein, EST, Moderately similar to A Chain A, Human
G, K





Tetrahydrofolate Dehydrogenase [ H. sapiens ], ESTs, Highly similar to T17244





hypothetical protein DKFZp586G1517.1 [ H. sapiens ], ESTs, Weakly similar to C1TC_RAT





C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes:





Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase;





Formyltetrahydrofolate synthetase] [ R. norvegicus ], expressed sequence AI647056,





hypothetical protein FLJ13105

4373
153
AA892310

DKFZP58600120 protein
F

1824
1210
U17971

DNA segment, Chr 10, ERATO Doi 398, expressed, EST, Weakly similar to 2102279A
K





protein Tyr phosphatase [ Rattus norvegicus ] [ R. norvegicus ], ESTs, Weakly similar to 41





MOUSE PROTEIN 4.1 [ M. musculus ], protein tyrosine phosphatase, non-receptor type





14, protein tyrosine phosphatase, non-receptor type 21

17535
1108
NM_031816

DNA segment, Chr 12, ERATO Doi 604, expressed, ESTs, Moderately similar to
E





hypothetical protein FLJ10416 similar to constitutive photomorph [ Homo sapiens ]





[ H. sapiens ], ESTs, Weakly similar to retinoblastoma binding protein 7 [ Rattus





norvegicus ] [ R. norvegicus ], Mus musculus , Similar to glutamate rich WD repeat protein





GRWD, clone IMAGE: 3498842, mRNA, partial cds, RIKEN cDNA 2610016K01 gene,





RIKEN cDNA 2610529I12 gene, constitutive photomorphogenic protein 1 (Arabidopsis),





retinoblastoma binding protein 4, retinoblastoma binding protein 7

2912
373
AI010220

DNA segment, Chr 14, ERATO Doi 728, expressed, RIKEN cDNA 6720456I16 gene,
GENERAL, A, F





claudin 10, claudin 15, claudin 7

22648
636
AI178996

DNA segment, Chr 15, Wayne State University 77, expressed, EST, Moderately similar to
A





K2C8_RAT Keratin, type II cytoskeletal 8 (Cytokeratin 8) (Cytokeratin endo A)





[ R. norvegicus ], ESTs, Highly similar to K2C8_RAT Keratin, type II cytoskeletal 8





(Cytokeratin 8) (Cytokeratin endo A) [ R. norvegicus ], ESTs, Moderately similar to I37982





Keratin 8 [ H. sapiens ], keratin 7, keratin 8, keratin complex 2, basic, gene 8

1460
1199
S76054

DNA segment, Chr 15, Wayne State University 77, expressed, EST, Moderately similar to
GENERAL, A, C, I, K





K2C8_RAT Keratin, type II cytoskeletal 8 (Cytokeratin 8) (Cytokeratin endo A)





[ R. norvegicus ], ESTs, Moderately similar to I37982 Keratin 8 [ H. sapiens ], Homo sapiens





mRNA; cDNA DKFZp434C107 (from clone DKFZp434C107), Homo sapiens mRNA;





cDNA DKFZp762H106 (from clone DKFZp762H106), keratin 8, keratin complex 2, basic,





gene 8

21157
271
AA946189

DNA segment, Chr 17, ERATO Doi 663, expressed, Homo sapiens cDNA FLJ25377 fis,
I





clone TST02084

5990
290
AA956907

DnaJ (Hsp40) homolog, subfamily C, member 8, Homo sapiens cDNA FLJ13613 fis,
GENERAL





clone PLACE1010856, Homo sapiens mRNA; cDNA DKFZp434C2016 (from clone





DKFZp434C2016), hypothetical protein DKFZp434B227

14484
628
AI177867

EH-domain containing 1, ESTs, Highly similar to intersectin 2 [ Homo sapiens ]
GENERAL





[ H. sapiens ], Mus musculus , Similar to EH-domain containing 2, clone MGC: 38650





IMAGE: 5356224, mRNA, complete cds, SH3 domain protein 1B, expressed sequence





AW108387, intersectin (SH3 domain protein 1A), intersectin 1 (SH3 domain protein)

10667
742
AI236366

ELAV (embryonic lethal, abnormal vision, Drosophila )-like 2 (Hu antigen B), ELAV
C





(embryonic lethal, abnormal vision, Drosophila )-like 4 (Hu antigen D), ESTs, Highly





similar to ELV4_RAT ELAV-like protein 4 (Paraneoplastic encephalomyelitis antigen





HuD) (Hu-antigen D) [ R. norvegicus ], ESTs, Moderately similar to ELV4_RAT ELAV-like





protein 4 (Paraneoplastic encephalomyelitis antigen HuD) (Hu-antigen D) [ R. norvegicus ],





ESTs, Moderately similar to PAB1 MOUSE POLYADENYLATE-BINDING PROTEIN 1





[ M. musculus ], ESTs, Weakly similar to PAB1 MOUSE POLYADENYLATE-BINDING





PROTEIN 1 [ M. musculus ], RIKEN cDNA 4932702K14 gene, poly A binding protein,





cytoplasmic 1, poly(A) binding protein, cytoplasmic 4 (inducible form)

17921
607
AI176422

electron-transferring-flavoprotein dehydrogenase
F

17268
686
AI231317

endothelial-derived gene, endothelial-derived gene 1
F

23194
159
AA892417

ephrin A1, ephrin-A1
GENERAL

21509
1044
NM_030847

epithelial membrane protein 3
G

21796
392
AI012221

EST X83352, ESTs, Weakly similar to intracellular chloride ion channel protein p64H1
GENERAL, K





[ Rattus norvegicus ] [ R. norvegicus ], RIKEN cDNA 5730531E12 gene, chloride intracellular





channel 1, chloride intracellular channel 3, chloride intracellular channel 4 (mitochondrial),





intracellular chloride ion channel protein p64H1

21797
488
AI072439

EST X83352, ESTs, Weakly similar to intracellular chloride ion channel protein p64H1
G, K





[ Rattus norvegicus ] [ R. norvegicus ], RIKEN cDNA 5730531E12 gene, chloride intracellular





channel 1, chloride intracellular channel 3, chloride intracellular channel 4 (mitochondrial),





intracellular chloride ion channel protein p64H1

12606
1016
NM_022547

EST, Highly similar to 10-formyltetrahydrofolate dehydrogenase [ Rattus norvegicus ]
E, K





[ R. norvegicus ], EST, Highly similar to FTDH_HUMAN 10-





FORMYLTETRAHYDROFOLATE DEHYDROGENASE [ H. sapiens ], ESTs, Moderately





similar to 10-formyltetrahydrofolate dehydrogenase [ Rattus norvegicus ] [ R. norvegicus ],





ESTs, Moderately similar to FTDH_HUMAN 10-FORMYLTETRAHYDROFOLATE





DEHYDROGENASE [ H. sapiens ], RIKEN cDNA 1810048F20 gene, RIKEN cDNA





2310020P08 gene, aldehyde dehydrogenase family 1, subfamily A7,





formyltetrahydrofolate dehydrogenase

7101
839
NM_012679

EST, Highly similar to Clusterin; Testostrone-repressed prostate message 2 [ Rattus
GENERAL, E





norvegicus ] [ R. norvegicus ], clusterin, clusterin (complement lysis inhibitor, SP-40, 40,





sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)

4589
343
AF062389

EST, Highly similar to A61209 hypertension-associated protein SA - rat [ R. norvegicus ],
GENERAL, D





ESTs, Highly similar to A61209 hypertension-associated protein SA - rat [ R. norvegicus ],





Homo sapiens cDNA FLJ31305 fis, clone LIVER1000104, moderately similar to Rattus





norvegicus kidney-specific protein (KS) mRNA, Homo sapiens cDNA FLJ33088 fis, clone





TRACH2000496, highly similar to Rattus norvegicus kidney-specific protein (KS) mRNA,





KIAA1504 protein, SA hypertension-associated homolog (rat), SA rat hypertension-





associated homolog, cat eye syndrome chromosome region, candidate 7, hypothetical





protein FLJ20581, solute carrier family 27 (fatty acid transporter), member 1, solute





carrier family 27 (fatty acid transporter), member 4

10015
973
NM_019289

EST, Highly similar to AR41_HUMAN ARP2/3 COMPLEX 41 KDA SUBUNIT [ H. sapiens ],
GENERAL, G, K





actin related protein 2/3 complex, subunit 1B (41 kD), actin related protein 2/3 complex,





subunit 1B (41 kDa)

10016
973
NM_019289

EST, Highly similar to AR41_HUMAN ARP2/3 COMPLEX 41 KDA SUBUNIT [ H. sapiens ],
GENERAL, G





actin related protein 2/3 complex, subunit 1B (41 kD), actin related protein 2/3 complex,





subunit 1B (41 kDa)

15137
1050
NM_031051

EST, Highly similar to C Chain C, Macrophage Migration Inhibitory Factor [ H. sapiens ],
L





EST, Moderately similar to C Chain C, Macrophage Migration Inhibitory Factor





[ H. sapiens ], EST, Moderately similar to MIF_RAT Macrophage migration inhibitory factor





(MIF) (Phenylpyruvate tautomerase) (Glutathione-binding 13 kDa protein) [ R. norvegicus ],





ESTs, Moderately similar to MIF_HUMAN MACROPHAGE MIGRATION INHIBITORY





FACTOR [ H. sapiens ], macrophage migration inhibitory factor, macrophage migration





inhibitory factor (glycosylation-inhibiting factor)

15138
1050
NM_031051

EST, Highly similar to C Chain C, Macrophage Migration Inhibitory Factor [ H. sapiens ],
C





EST, Moderately similar to C Chain C, Macrophage Migration Inhibitory Factor





[ H. sapiens ], EST, Moderately similar to MIF_RAT Macrophage migration inhibitory factor





(MIF) (Phenylpyruvate tautomerase) (Glutathione-binding 13 kDa protein) [ R. norvegicus ],





ESTs, Moderately similar to MIF_HUMAN MACROPHAGE MIGRATION INHIBITORY





FACTOR [ H. sapiens ], macrophage migration inhibitory factor, macrophage migration





inhibitory factor (glycosylation-inhibiting factor)

1246
847
NM_012770

EST, Highly similar to CYG2_HUMAN GUANYLATE CYCLASE SOLUBLE, BETA-2
GENERAL, J





CHAIN [ H. sapiens ], guanylate cyclase 1, soluble, beta 2, guanylate cyclase 1, soluble,





beta 3

7892
661
AI229172

EST, Highly similar to FIBA_RAT Fibrinogen alpha/alpha-E chain precursor
K





[ R. norvegicus ], Homo sapiens clone HQ0582, Mus musculus , Similar to angiopoietin-like





factor, clone MGC: 32448 IMAGE: 5043159, mRNA, complete cds, angiopoietin,





expressed sequence AI303526, fibrinogen, A alpha polypeptide, fibrinogen, alpha





polypeptide, fibrinogen, gamma polypeptide

15850
749
AI236795

EST, Highly similar to HS9B MOUSE HEAT SHOCK PROTEIN HSP 90-BETA
K





[ M. musculus ], EST, Weakly similar to HHMS84 heat shock protein 84 - mouse





[ M. musculus ], ESTs, Highly similar to HS9A_HUMAN HEAT SHOCK PROTEIN HSP 90-





ALPHA [ H. sapiens ], ESTs, Highly similar to T46243 hypothetical protein





DKFZp761K0511.1 [ H. sapiens ], expressed sequence C81438, heat shock 90 kD protein





1, beta, heat shock protein, 84 kDa, 1, heat shock protein, 86 kDa 1

16967
895
NM_013146

EST, Highly similar to JH0628 caldesmon [ H. sapiens ], ESTs, Weakly similar to JC5314
E





CDC28/cdc2-like kinase associating arginine-serine cyclophilin [ H. sapiens ], Mus





musculus , Similar to Caldesmon 1, clone MGC: 30319 IMAGE: 5148205, mRNA, complete





cds, RIKEN cDNA 4833423D12 gene, caldesmon 1, major urinary protein 4

17684
154
AA892345

EST, Highly similar to M2GD_HUMAN DIMETHYLGLYCINE DEHYDROGENASE,
GENERAL, I





MITOCHONDRIAL PRECURSOR [ H. sapiens ], ESTs, Weakly similar to





DIMETHYLGLYCINE DEHYDROGENASE PRECURSOR [ R. norvegicus ], RIKEN cDNA





1200014D15 gene, dimethylglycine dehydrogenase precursor, expressed sequence





AW495222, hypothetical protein FLJ10079, sarcosine dehydrogenase

21025
88
AA859241

EST, Highly similar to OM25_RAT MITOCHONDRIAL OUTER MEMBRANE PROTEIN
GENERAL, A, C





25 (NPW16) [ R. norvegicus ], EST, Weakly similar to OM25_RAT Mitochondrial outer





membrane protein 25 (NPW16) [ R. norvegicus ], hypothetical protein FLJ11271,





synaptojanin 2 binding protein

21024
1021
NM_022599

EST, Highly similar to OM25_RAT MITOCHONDRIAL OUTER MEMBRANE PROTEIN
GENERAL





25 (NPW16) [ R. norvegicus ], EST, Weakly similar to OM25_RAT Mitochondrial outer





membrane protein 25 (NPW16) [ R. norvegicus ], hypothetical protein FLJ11271,





synaptojanin 2 binding protein

15876
169
AA892582

EST, Highly similar to RL8_HUMAN 60S ribosomal protein L8 [ R. norvegicus ], EST,
G





Weakly similar to JN0923 ribosomal protein L8, cytosolic [ H. sapiens ], ESTs, Highly





similar to R5RTL8 ribosomal protein L8, cytosolic [validated] - rat [ R. norvegicus ], ESTs,





Highly similar to RL8_HUMAN 60S RIBOSOMAL PROTEIN L [ M. musculus ], ESTs,





Moderately similar to RL8_HUMAN 60S RIBOSOMAL PROTEIN L [ M. musculus ],





expressed sequence AL024098, ribosomal protein L8

343
844
NM_012747

EST, Highly similar to STA3_RAT Signal transducer and activator of transcription 3
L





[ R. norvegicus ], signal transducer and activator of transcription 3, signal transducer and





activator of transcription 3 (acute-phase response factor)

3439
185
AA893000

EST, Highly similar to T00335 hypothetical protein KIAA0564 [ H. sapiens ], KIAA0564
B





protein

3822
211
AA900863

EST, Moderately similar to HLA-B-associated transcript 1A; DNA segment, Chr 17,
GENERAL, H





human D6S81E 1; nuclear RNA helicase Bat1 [ Mus musculus ] [ M. musculus ], EST,





Weakly similar to HE47_RAT Probable ATP-dependent RNA helicase p47





[ R. norvegicus ], ESTs, Moderately similar to IF41_HUMAN EUKARYOTIC INITIATION





FACTOR 4A-I [ M. musculus ], ESTs, Weakly similar to HE47 RAT PROBABLE ATP-





DEPENDENT RNA HELICASE P47 [ R. norvegicus ], HLA-B-associated transcript 1A,





RIKEN cDNA 2410004K13 gene, RIKEN cDNA 2600001H07 gene, RIKEN cDNA





2610307C23 gene, eukaryotic translation initiation factor 4A, isoform 1, eukaryotic





translation initiation factor 4A1

3823
706
AI233147

EST, Moderately similar to HLA-B-associated transcript 1A; DNA segment, Chr 17,
GENERAL





human D6S81E 1; nuclear RNA helicase Bat1 [ Mus musculus ] [ M. musculus ], EST,





Weakly similar to HE47_RAT Probable ATP-dependent RNA helicase p47





[ R. norvegicus ], ESTs, Moderately similar to IF41_HUMAN EUKARYOTIC INITIATION





FACTOR 4A-I [ M. musculus ], ESTs, Weakly similar to HE47 RAT PROBABLE ATP-





DEPENDENT RNA HELICASE P47 [ R. norvegicus ], HLA-B-associated transcript 1A,





RIKEN cDNA 2410004K13 gene, RIKEN cDNA 2600001H07 gene, RIKEN cDNA





2610307C23 gene, eukaryotic translation initiation factor 4A, isoform 1, eukaryotic





translation initiation factor 4A1

23115
29
AA801165

EST, Moderately similar to RIKEN cDNA 1700113O17 [ Mus musculus ] [ M. musculus ],
A, F





H2A histone family, member L, Homo sapiens , clone MGC: 21597 IMAGE: 4511035,





mRNA, complete cds, Mus musculus , similar to H2A histone family, member O, clone





MGC: 36202 IMAGE: 5055276, mRNA, complete cds, expressed sequence R75370

15489
1060
NM_031137

EST, Moderately similar to tripeptidylpeptidase II [ Rattus norvegicus ] [ R. norvegicus ],
F





ESTs, Highly similar to TRIPEPTIDYL-PEPTIDASE II [ M. musculus ], tripeptidyl peptidase





II

14983
637
AI179150

EST, Moderately similar to 0806162B cytochrome b [ M. musculus ], EST, Moderately
D





similar to 810024B cytochrome b [ H. sapiens ], EST, Weakly similar to 0806162B





cytochrome b [ M. musculus ], EST, Weakly similar to 0812187A cytochrome b [ Rattus





norvegicus ] [ R. norvegicus ], EST, Weakly similar to 810024M URF 6 [ H. sapiens ]

1570
1164
NM_053857

EST, Moderately similar to 2021415A initiation factor 4E-binding protein: ISOTYPE = 1
A





[ H. sapiens ], ESTs, Weakly similar to A55258 insulin-stimulated phosphoprotein PHAS-I-





rat [ R. norvegicus ], RIKEN cDNA 1110004O12 gene, eukaryotic translation initiation factor





4E binding protein 1, eukaryotic translation initiation factor 4E binding protein 2,





eukaryotic translation initiation factor 4E binding protein 3

15185
1062
NM_031140

EST, Moderately similar to A25074 vimentin [ H. sapiens ], EST, Weakly similar to A25074
GENERAL





vimentin [ H. sapiens ], ESTs, Weakly similar to A25074 vimentin [ H. sapiens ], Mus





musculus , similar to FLJ00074 protein, clone MGC: 36549 IMAGE: 4952810, mRNA,





complete cds, desmuslin, intermediate filament-like MGC: 2625, vimentin

1501
489
AI072634

EST, Moderately similar to A40452 keratin 21, type I, cytoskeletal - rat [ R. norvegicus ],
GENERAL, C, G, K





ESTs, Weakly similar to A40452 keratin 21, type I, cytoskeletal - rat [ R. norvegicus ],





RIKEN cDNA 9030623C06 gene, Rat cytokeratin 21 mRNA, complete cds, keratin 18,





keratin complex 1, acidic, gene 18

9504
549
AI136723

EST, Moderately similar to HKR3_HUMAN KRUEPPEL-RELATED ZINC FINGER
F





PROTEIN 3 [ H. sapiens ], EST, Weakly similar to ZF37_RAT Zinc finger protein 37 (Zfp-





37) [ R. norvegicus ], ESTs, Weakly similar to I48668 zinc finger protein 51 - mouse





[ M. musculus ], ESTs, Weakly similar to ZF93_MOUSE ZINC FINGER PROTEIN 93 (ZFP-





93) [ M. musculus ], GLI-Kruppel family member HKR3, Mus musculus , clone MGC: 35978





IMAGE: 5353641, mRNA, complete cds, zinc finger protein 37, zinc finger protein 37





homolog (mouse) zinc finger protein 51

22412
1005
NM_022392

EST, Moderately similar to ISI1_RAT Insulin-induced protein 1 (Insulin-induced growth
C, H





response protein CL-6) (Immediate-early protein CL-6) [ R. norvegicus ], RIKEN cDNA





2900053I11 gene, insulin induced gene 1, insulin induced protein 2

22413
1005
NM_022392

EST, Moderately similar to ISI1_RAT Insulin-induced protein 1 (Insulin-induced growth
C, H





response protein CL-6) (Immediate-early protein CL-6) [ R. norvegicus ], RIKEN cDNA





2900053I11 gene, insulin induced gene 1, insulin induced protein 2

22414
1005
NM_022392

EST, Moderately similar to ISI1_RAT Insulin-induced protein 1 (Insulin-induced growth
H





response protein CL-6) (Immediate-early protein CL-6) [ R. norvegicus ], RIKEN cDNA





2900053I11 gene, insulin induced gene 1, insulin induced protein 2

22415
1005
NM_022392

EST, Moderately similar to ISI1_RAT Insulin-induced protein 1 (Insulin-induced growth
C





response protein CL-6) (Immediate-early protein CL-6) [ R. norvegicus ], RIKEN cDNA





2900053I11 gene, insulin induced gene 1, insulin induced protein 2

165
561
AI145329

EST, Moderately similar to MDHM_RAT MALATE DEHYDROGENASE,
F





MITOCHONDRIAL PRECURSOR [ R. norvegicus ], EST, Weakly similar to DEMSMM





malate dehydrogenase [ M. musculus ], malate dehydrogenase 2, NAD (mitochondrial),





malate dehydrogenase, mitochondrial

1478
843
NM_012744

EST, Moderately similar to PYC_RAT Pyruvate carboxylase, mitochondrial precursor
GENERAL





(Pyruvic carboxylase) (PCB) [ R. norvegicus ], Mus musculus , Similar to Propionyl





Coenzyme A carboxylase, alpha polypeptide, clone MGC: 11973 IMAGE: 3601148,





mRNA, complete cds, pyruvate carboxylase, pyruvate decarboxylase

1479
843
NM_012744

EST, Moderately similar to PYC_RAT Pyruvate carboxylase, mitochondrial precursor
D





(Pyruvic carboxylase) (PCB) [ R. norvegicus ], Mus musculus , Similar to Propionyl





Coenzyme A carboxylase, alpha polypeptide, clone MGC: 11973 IMAGE: 3601148,





mRNA, complete cds, pyruvate carboxylase, pyruvate decarboxylase

20873
616
AI177042

EST, Moderately similar to R3RT19 ribosomal protein S19, cytosolic [validated] - rat
G





[ R. norvegicus ], EST, Weakly similar to RS19_HUMAN 40S RIBOSOMAL PROTEIN S19





[ H. sapiens ]

4441
1249
X62146

EST, Moderately similar to RL11_HUMAN 60S RIBOSOMAL PROTEIN L11 [ H. sapiens ],
G





EST, Moderately similar to RL11_HUMAN 60S ribosomal protein L11 [ R. norvegicus ],





EST, Weakly similar to RL11_HUMAN 60S RIBOSOMAL PROTEIN L11 [ H. sapiens ],





ESTs, Highly similar to RIKEN cDNA 2010203J19 [ Mus musculus ] [ M. musculus ], ESTs,





Moderately similar to RL11_HUMAN 60S RIBOSOMAL PROTEIN L11 [ H. sapiens ],





RIKEN cDNA 2010203J19 gene, ribosomal protein L11

17175
1243
X58389

EST, Moderately similar to RL17_HUMAN 60S RIBOSOMAL PROTEIN L17 [ H. sapiens ],
GENERAL





EST, Weakly similar to RL17 RAT 60S RIBOSOMAL PROTEIN L17 [ R. norvegicus ], EST,





Weakly similar to RL17_HUMAN 60S RIBOSOMAL PROTEIN L17 [ H. sapiens ], ESTs,





Highly similar to R5HU22 ribosomal protein L17, cytosolic [ H. sapiens ], ESTs, Highly





similar to RL17 RAT 60S RIBOSOMAL PROTEIN L17 [ R. norvegicus ], ESTs, Weakly





similar to R5HU22 ribosomal protein L17, cytosolic [ H. sapiens ], Mus musculus adult





female placenta cDNA, RIKEN full-length enriched library, clone: 1600029O15: hexokinase





1 full insert sequence ribosomal protein L17

18642
500
AI102023

EST, Moderately similar to RL35_HUMAN 60S RIBOSOMAL PROTEIN L3 [ H. sapiens ],
C





EST, Moderately similar to RL35_RAT 60S RIBOSOMAL PROTEIN L35 [ R. norvegicus ],





Homo sapiens , clone IMAGE: 4183312, mRNA, partial cds, ribosomal protein L35

24108
679
AI230728

EST, Moderately similar to Rna-Binding Domain Of The U1a Spliceosomal Protein
G





U1a117, Nmr, 43 Structures {SUB 2-117 [ H. sapiens ], EST, Weakly similar to Rna-Binding





Domain Of The U1a Spliceosomal Protein U1a117, Nmr, 43 Structures {SUB 2-117





[ H. sapiens ], ESTs, Moderately similar to Rna-Binding Domain Of The U1a Spliceosomal





Protein U1a117, Nmr, 43 Structures {SUB 2-117 [ H. sapiens ], U2 small nuclear





ribonucleoprotein B, small nuclear ribonucleoprotein polypeptide A

13647
155
AA892367

EST, Moderately similar to S34195 ribosomal protein L3, cytosolic [ H. sapiens ], EST,
G





Weakly similar to S34195 ribosomal protein L3, cytosolic [ H. sapiens ], ESTs, Highly





similar to S34195 ribosomal protein L3, cytosolic [ H. sapiens ], ESTs, Moderately similar to





RL3_RAT 60S RIBOSOMAL PROTEIN L3 (L4) [ R. norvegicus ], ESTs, Weakly similar to





RL3 MOUSE 60S RIBOSOMAL PROTEIN L3 [ M. musculus ], RIKEN cDNA 1110057H16





gene, ribosomal protein L3, ribosomal protein L3-like

13646
1250
X62166

EST, Moderately similar to S34195 ribosomal protein L3, cytosolic [ H. sapiens ], EST,
GENERAL, A, G





Weakly similar to S34195 ribosomal protein L3, cytosolic [ H. sapiens ], ESTs, Highly





similar to S34195 ribosomal protein L3, cytosolic [ H. sapiens ], ESTs, Moderately similar to





RL3_RAT 60S RIBOSOMAL PROTEIN L3 (L4) [ R. norvegicus ], ESTs, Weakly similar to





RL3 MOUSE 60S RIBOSOMAL PROTEIN L3 [ M. musculus ], RIKEN cDNA 1110057H16





gene, ribosomal protein L3, ribosomal protein L3-like

2232
303
AA963990

EST, Moderately similar to S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ],
D





ESTs, Highly similar to S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ],





ESTs, Moderately similar to S70642 ubiquitin ligase Nedd4 - rat (fragment)





[ R. norvegicus ], ESTs, Weakly similar to NED4 MOUSE NEDD-4 PROTEIN





[ M. musculus ], neural precursor cell expressed, developmentally down-regulated 4, neural





precursor cell expressed, developmentally down-regulated gene 4a

15191
608
AI176456

EST, Moderately similar to SMHU1E metallothionein 1E [ H. sapiens ], ESTs, Highly similar
GENERAL, F, L





to SMHU1B metallothionein 1B [ H. sapiens ], H. sapiens mRNA for metallothionein isoform





1R, Homo sapiens metallothionein 1H-like protein mRNA, complete cds, Homo sapiens





unknown mRNA, Homo sapiens , Similar to RNA helicase-related protein, clone





MGC: 9246 IMAGE: 3892441, mRNA, complete cds, Mus musculus , metallothionein 2A,





clone MGC: 30400 IMAGE: 4501155, mRNA, complete cds, metallothionein 1H,





metallothionein 1X metallothionein 2

13607
640
AI179403

EST, Moderately similar to U520_HUMAN U5 SMALL NUCLEAR
H





RIBONUCLEOPROTEIN 200 KDA HELICASE (U5 SNRNP-SPECIFIC 200 KDA





PROTEIN) (U5-200 KD) [ H. sapiens ], Homo sapiens cDNA FLJ11356 fis, clone





HEMBA1000150, highly similar to Homo sapiens putative RNA helicase mRNA, Homo





sapiens cDNA FLJ11521 fis, clone HEMBA1002486, KIAA0788 protein, RNA helicase





family

21491
1027
NM_022951

EST, Weakly similar to proline rich protein 2 [ Mus musculus ] [ M. musculus ], EST, Weakly
B





similar to ZAP3_MOUSE Nuclear protein ZAP3 [ M. musculus ], ESTs, Weakly similar to





proline rich protein 2 [ Mus musculus ] [ M. musculus ], expressed sequence AA408880,





pantothenate kinase, proline rich protein 2, protein phosphatase 1, regulatory subunit 10

20810
1235
X14181

EST, Weakly similar to ribosomal protein L18a; 60S ribosomal protein L18a [ Homo
G





sapiens ] [ H. sapiens ], ESTs, Highly similar to ribosomal protein L18a; 60S ribosomal





protein L18a [ Homo sapiens ] [ H. sapiens ]

18269
129
AA891769

EST, Weakly similar to SC65 synaptonemal complex protein [ Rattus norvegicus ]
GENERAL, D, L





[ R. norvegicus ], ESTs, Weakly similar to SC65 synaptonemal complex protein [ Rattus





norvegicus ] [ R. norvegicus ], SC65 synaptonemal complex protein, cartilage associated





protein, growth suppressor 1, nucleolar autoantigen (55 kD) similar to rat synaptonemal





complex protein

6917
1
AA012709

EST, Weakly similar to splicing factor 3b, subunit 1, 155 kDa [ Mus musculus ]
B





[ M. musculus ], ESTs, Weakly similar to S3B1_HUMAN Splicing factor 3B subunit 1





(Spliceosome associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA splicing factor





SF3b 155 kDa subunit) [ H. sapiens ], splicing factor 3b, subunit 1, 155 kDa, splicing factor





3b, subunit 1, 155 kD

3125
682
AI231028

EST, Weakly similar to 2102279A protein Tyr phosphatase [ Rattus norvegicus ]
K





[ R. norvegicus ], erythrocyte membrane protein band 4.1-like 1, erythrocyte protein band





4.1-like 1, protein tyrosine phosphatase 2E, protein tyrosine phosphatase, non-receptor





type 14, protein tyrosine phosphatase, non-receptor type 21

15135
1170
NM_053971

EST, Weakly similar to 60S RIBOSOMAL PROTEIN L6 [ M. musculus ], ESTs, Weakly
G





similar to 60S RIBOSOMAL PROTEIN L6 [ M. musculus ], ribosomal protein L6

3995
388
AI011678

EST, Weakly similar to A33880 syndecan 2 [ H. sapiens ], Mus musculus , clone
GENERAL, I, K





IMAGE: 4983756, mRNA, partial cds, syndecan 2, syndecan 2 (heparan sulfate





proteoglycan 1, cell surface-associated, fibroglycan)

1529
884
NM_013082

EST, Weakly similar to A33880 syndecan 2 [ H. sapiens ], Mus musculus , clone
GENERAL, B, F, I





IMAGE: 4983756, mRNA, partial cds, syndecan 2, syndecan 2 (heparan sulfate





proteoglycan 1, cell surface-associated, fibroglycan)

13633
1041
NM_024403

EST, Weakly similar to A45377 transcription factor ATF4 [ H. sapiens ], ESTs, Highly
GENERAL





similar to A45377 transcription factor ATF4 [ H. sapiens ], activating transcription factor 4,





activating transcription factor 4 (tax-responsive enhancer element B67), activating





transcription factor 5

13634
1041
NM_024403

EST, Weakly similar to A45377 transcription factor ATF4 [ H. sapiens ], ESTs, Highly
GENERAL





similar to A45377 transcription factor ATF4 [ H. sapiens ], activating transcription factor 4,





activating transcription factor 4 (tax-responsive enhancer element B67), activating





transcription factor 5

1490
1226
U63839

EST, Weakly similar to A56573 nuclear pore complex glycoprotein p62 - mouse
E





[ M. musculus ], Mus musculus , clone IMAGE: 5148310, mRNA, RIKEN cDNA 1700017F11





gene, melanoma antigen, family D, 3, nucleoporin 98, nucleoporin 98 kD, nucleoporin p45,





plasma membrane associated protein, S3-12

17378
1061
NM_031138

EST, Weakly similar to B41222 ubiquitin - protein ligase [ H. sapiens ], ESTs, Highly similar
D





to ubiquitin conjugating enzyme [ Rattus norvegicus ] [ R. norvegicus ], ESTs, Highly similar





to A41222 ubiquitin-protein ligase [ H. sapiens ], ESTs, Moderately similar to B41222





ubiquitin-protein ligase [ H. sapiens ], ESTs, Weakly similar to UBC2_HUMAN UBIQUITIN-





CONJUGATING ENZYME E2-17 KD [ M. musculus ], RIKEN cDNA 2610301N02 gene,





expressed sequence AI327276, ubiquitin-conjugating enzyme E2A (RAD6 homolog),





ubiquitin-conjugating enzyme E2A, RAD6 homolog ( S. cerevisiae ), ubiquitin-conjugating





enzyme E2B (RAD6 homolog), ubiquitin-conjugating enzyme E2B, RAD6 homology ( S. cerevisiae ),





ubiquitin-conjugating enzyme E2C

2010
1206
U05675

EST, Weakly similar to beta-fibrinogen precursor [ H. sapiens ], ESTs, Moderately similar to
K





ANL2_MOUSE Angiopoietin-related protein 2 precursor (Angiopoietin-like 2)





[ M. musculus ], ESTs, Weakly similar to FIBB_RAT Fibrinogen beta chain precursor





[Contains: Fibrinopeptide B] [ R. norvegicus ], Mus musculus , Similar to angiopoietin-





related protein 5, clone MGC: 32467 IMAGE: 5049765, mRNA, complete cds, Mus





musculus , Similar to fibrinogen-like 1, clone MGC: 37822 IMAGE: 5098805, mRNA,





complete cds angiopoietin-like 2, expressed sequence AI593246

16929
1056
NM_031108

EST, Weakly similar to COLLAGEN ALPHA 2(VI) CHAIN PRECURSOR [ M. musculus ],
G





Mus musculus , Similar to splicing factor, arginine/serine-rich 8 (suppressor-of-white-





apricot homolog, Drosophila ), clone MGC: 31019 IMAGE: 5006904, mRNA, complete cds,





RIKEN cDNA 3010033P07 gene, expressed sequence AL022771, expressed sequence





AL022885, ribosomal protein S9

15653
1236
X14210

EST, Weakly similar to G02526 NADH dehydrogenase [ H. sapiens ], NADH
G





dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (13 kD, B13), RIKEN cDNA





2900002J19 gene

17734
1114
NM_031970

EST, Weakly similar to HHHU27 heat shock protein 27 [ H. sapiens ], ESTs, Highly similar
GENERAL, C, I





to HHHU27 heat shock protein 27 [ H. sapiens ], ESTs, Moderately similar to HHHU27 heat





shock protein 27 [ H. sapiens ], heat shock 27 kD protein 1, hypothetical protein MGC10974

17735
1114
NM_031970

EST, Weakly similar to HHHU27 heat shock protein 27 [ H. sapiens ], ESTs, Highly similar
C, K





to HHHU27 heat shock protein 27 [ H. sapiens ], ESTs, Moderately similar to HHHU27 heat





shock protein 27 [ H. sapiens ], heat shock 27 kD protein 1, hypothetical protein MGC10974

17736
1114
NM_031970

EST, Weakly similar to HHHU27 heat shock protein 27 [ H. sapiens ], ESTs, Highly similar
H, K





to HHHU27 heat shock protein 27 [ H. sapiens ], ESTs, Moderately similar to HHHU27 heat





shock protein 27 [ H. sapiens ], heat shock 27 kD protein 1, hypothetical protein MGC10974

9191
485
AI072107

EST, Weakly similar to I73674 chlordecone reductase homolog [ H. sapiens ], ESTs, Highly
A





similar to 2008147B protein RAKc [ Rattus norvegicus ] [ R. norvegicus ], ESTs, Highly





similar to DBDD_HUMAN TRANS-1,2-DIHYDROBENZENE-1,2-DIOL





DEHYDROGENASE [ H. sapiens ], ESTs, Moderately similar to DBDD_HUMAN TRANS-





1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE [ H. sapiens ], ESTs, Weakly





similar to DHBX MOUSE ESTRADIOL 17 BETA-DEHYDROGENASE, A-SPECIFIC





[ M. musculus ], Homo sapiens truncated AKR mRNA for truncated aldo-keto reductase





type B, partial cds, aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-





alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4),





hydroxysteroid (17-beta) dehydrogenase 5

7414
557
AI137586

EST, Weakly similar to IMB3_HUMAN IMPORTIN BETA-3 SUBUNIT [ H. sapiens ], Homo
K





sapiens cDNA FLJ12978 fis, clone NT2RP2006321, RAN binding protein 6, importin 4

23195
223
AA925026

EST, Weakly similar to MAST CELL PROTEASE 7 PRECURSOR [ M. musculus ], ESTs,
GENERAL





Weakly similar to A35863 tryptase [ H. sapiens ], ESTs, Weakly similar to MCT6 MOUSE





MAST CELL PROTEASE 6 PRECURSOR [ M. musculus ], ESTs, Weakly similar to





MCT7_RAT Mast cell protease 7 precursor (RMCP-7) (Tryptase, skin) [ R. norvegicus ],





Homo sapiens cDNA FLJ30744 fis, clone FEBRA2000378, mast cell protease 7, tryptase





beta 1, tryptase delta 1, tryptase, alpha

24472
117
AA875523

EST, Weakly similar to MOHU6N myosin alkali light chain 6, nonmuscle form [ H. sapiens ],
L





myosin light chain, alkali, nonmuscle, myosin, light polypeptide 6, alkali, smooth muscle





and non-muscle

12587
668
AI229979

EST, Weakly similar to MOT2_RAT Monocarboxylate transporter 2 (MCT 2)
GENERAL





[ R. norvegicus ], ESTs, Weakly similar to MOT2 MOUSE MONOCARBOXYLATE





TRANSPORTER 2 [ M. musculus ], ESTs, Weakly similar to MOT2_RAT Monocarboxylate





transporter 2 (MCT 2) [ R. norvegicus ], ESTs, Weakly similar to MOT3_HUMAN





MONOCARBOXYLATE TRANSPORTER 3 [ H. sapiens ], solute carrier family 16





(monocarboxylic acid transporters), member 6, solute carrier family 16 (monocarboxylic





acid transporters), member 7

725
1225
U62316

EST, Weakly similar to MOT2_RAT Monocarboxylate transporter 2 (MCT 2)
B





[ R. norvegicus ], ESTs, Weakly similar to MOT2 MOUSE MONOCARBOXYLATE





TRANSPORTER 2 [ M. musculus ], ESTs, Weakly similar to MOT2_RAT Monocarboxylate





transporter 2 (MCT 2) [ R. norvegicus ], ESTs, Weakly similar to MOT3_HUMAN





MONOCARBOXYLATE TRANSPORTER 3 [ H. sapiens ], solute carrier family 16





(monocarboxylic acid transporters), member 6, solute carrier family 16 (monocarboxylic





acid transporters), member 7

1558
1217
U28504

EST, Weakly similar to NPT1_RAT RENAL SODIUM-DEPENDENT PHOSPHATE
H





TRANSPORT PROTEIN 1 (SODIUM/PHOSPHATE COTRANSPORTER 1) (NA(+)/PI





COTRANSPORTER 1) (RENAL SODIUM-PHOSPHATE TRANSPORT PROTEIN 1)





(RENAL NA+-DEPENDENT PHOSPHATE COTRANSPORTER 1) [ R. norvegicus ], ESTs,





Weakly similar to RENAL SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN





1 [ M. musculus ], Mus musculus , Similar to solute carrier family 17 (sodium phosphate),





member 2, clone MGC: 19073 IMAGE: 4193755, mRNA, complete cds, expressed





sequence AW261723, solute carrier family 17 (sodium phosphate), member 1, solute





carrier family 17 (sodium phosphate), member 2, solute carrier family 17 (sodium





phosphate), member 3, solute carrier family 17 (sodium phosphate), member 4, solute





carrier family 17 vesicular glutamate transporter), member 1

14138
94
AA859700

EST, Weakly similar to PPOX MOUSE PROTOPORPHYRINOGEN OXIDASE
GENERAL





[ M. musculus ], protoporphyrinogen oxidase

2109
1010
NM_022511

EST, Weakly similar to PRO1 MOUSE PROFILIN I [ M. musculus ], EST, Weakly similar to
G





PRO2_HUMAN PROFILIN II [ H. sapiens ], ESTs, Weakly similar to PRO2_HUMAN





PROFILIN II [ H. sapiens ], Mk1 protein, profilin 1

5208
747
AI236754

EST, Weakly similar to PRP3 MOUSE PROLINE-RICH PROTEIN MP-3 [ M. musculus ],
G





ESTs, Weakly similar to PRP3 MOUSE PROLINE-RICH PROTEIN MP-3 [ M. musculus ],





Mus musculus , clone IMAGE: 5251262, mRNA, partial cds, expressed sequence C78515,





pregnancy-induced growth inhibitor

18606
1239
X53504

EST, Weakly similar to RL12_HUMAN 60S RIBOSOMAL PROTEIN L12 [ H. sapiens ],
GENERAL





ESTs, Weakly similar to RL12_HUMAN 60S RIBOSOMAL PROTEIN L12 [ H. sapiens ],





ribosomal protein L12

6049
3
AA685178

EST, Weakly similar to S49326 nascent polypeptide-associated complex alpha chain
F





[ H. sapiens ], EST, Weakly similar to T30827 nascent polypeptide-associated complex





alpha chain, non-muscle splice form - mouse [ M. musculus ], FKSG17, KIAA0363 protein,





expressed sequence AL022831, nascent-polypeptide-associated complex alpha





polypeptide

11953
501
AI102505

EST, Weakly similar to S71929 cytochrome-c oxidase (EC 1.9.3.1) chain VIII precursor,
A





hepatic - mouse [ M. musculus ], cytochrome c oxidase, subunit VIIIa, heme-regulated





initiation factor 2-alpha kinase

6059
632
AI178245

EST, Weakly similar to T13963 formin related protein, lymphocyte specific - mouse
GENERAL, J





[ M. musculus ], ESTs, Highly similar to T13963 formin related protein, lymphocyte specific -





mouse [ M. musculus ], ESTs, Moderately similar to T13963 formin related protein,





lymphocyte specific - mouse [ M. musculus ], Homo sapiens mRNA; cDNA DKFZp762B245





(from clone DKFZp762B245); partial cds, formin homology 2 domain containing 1, formin-





like

17159
787
J00797

EST, Weakly similar to TBA1 MOUSE TUBULIN ALPHA-1 CHAIN [ M. musculus ], tubulin,
GENERAL, G, K





alpha 1, tubulin, alpha 2, tubulin, alpha 3, tubulin, alpha 6, tubulin, alpha 7, tubulin, alpha,





ubiquitous

17161
1002
NM_022298

EST, Weakly similar to TBA1 MOUSE TUBULIN ALPHA-1 CHAIN [ M. musculus ], tubulin,
GENERAL





alpha 1, tubulin, alpha 2, tubulin, alpha 3, tubulin, alpha 6, tubulin, alpha 7, tubulin, alpha,





ubiquitous

13974
103
AA860030

EST, Weakly similar to TBB5 MOUSE TUBULIN BETA-5 CHAIN [ M. musculus ], RIKEN
GENERAL, F





cDNA 2310061K05 gene, RIKEN cDNA 2410129E14 gene, RIKEN cDNA 4930542G03





gene, tubulin, beta 5, tubulin, beta polypeptide, tubulin, beta, 2, tubulin, beta, 5

13973
334
AB011679

EST, Weakly similar to TBB5 MOUSE TUBULIN BETA-5 CHAIN [ M. musculus ], RIKEN
E





cDNA 2310061K05 gene, RIKEN cDNA 2410129E14 gene, RIKEN cDNA 4930542G03





gene, tubulin, beta 5, tubulin, beta polypeptide, tubulin, beta, 2, tubulin, beta, 5

15273
1063
NM_031237

EST, Weakly similar to UB5C_HUMAN Ubiquitin-conjugating enzyme E2-17 kDa 3
E





(Ubiquitin-protein ligase) (Ubiquitin carrier protein) (E2(17)KB 3) [ R. norvegicus ], ESTs,





Weakly similar to S53358 ubiquitin-conjugating enzyme E2.17 kB - rat [ R. norvegicus ],





Homo sapiens EST from clone 37208, full insert, RIKEN cDNA 1100001F19 gene,





RIKEN cDNA 1600028I17 gene, prefoldin 5, ubiquitin-conjugating enzyme E2D 3





(UBC4/5 homolog, yeast)

15277
1063
NM_031237

EST, Weakly similar to UB5C_HUMAN Ubiquitin-conjugating enzyme E2-17 kDa 3
D





(Ubiquitin-protein ligase) (Ubiquitin carrier protein) (E2(17)KB 3) [ R. norvegicus ], ESTs,





Weakly similar to S53358 ubiquitin-conjugating enzyme E2.17 kB - rat [ R. norvegicus ],





Homo sapiens EST from clone 37208, full insert, RIKEN cDNA 1100001F19 gene,





RIKEN cDNA 1600028I17 gene, prefoldin 5, ubiquitin-conjugating enzyme E2D 3





(UBC4/5 homolog, yeast)

15302
9
AA799518

ESTs, Highly similar to hypothetical protein FLJ13725; KIAA1930 protein [ Homo sapiens ]
GENERAL





[ H. sapiens ]

15303
9
AA799518

ESTs, Highly similar to hypothetical protein FLJ13725; KIAA1930 protein [ Homo sapiens ]
F





[ H. sapiens ]

16913
652
AI228236

ESTs, Highly similar to neuronal protein 17.3; similar to mouse neuronal protein 15.6
E





[ Homo sapiens ] [ H. sapiens ], nuclear protein 15.6

23307
1176
NM_057119

ESTs, Highly similar to TLS-associated serine-arginine protein 1, isoform 1; TLS-
D





associated serine-arginine protein 1; TLS-associated protein TASR [ Homo sapiens ]





[ H. sapiens ], ESTs, Weakly similar to splicing factor, arginine/serine-rich (transformer 2





Drosophila homolog) 10 [ Rattus norvegicus ] [ R. norvegicus ], Mus musculus





hexaribonucleotide binding protein 3 (Hrnbp3) mRNA, partial cds, RIKEN cDNA





1500010G04 gene, neural-salient serine/arginine-rich, silica-induced gene 41, splicing





factor arginine/serine-rich 10 (transformer 2 homolog Drosophila )

2250
1024
NM_022643

ESTs, Highly similar to 0506206A histone H2B [ Rattus norvegicus ] [ R. norvegicus ], H2B
GENERAL





histone family, member A, H2B histone family, member B, H2B histone family, member





D, H2B histone family, member G, H2B histone family, member H, H2B histone family,





member K, histone family member

20082
771
AI639488

ESTs, Highly similar to 1814460A p53-associated protein [ H. sapiens ], Mdm2,
GENERAL, H, I, J





transformed 3T3 cell double minute 2, p53 binding protein (mouse), transformed mouse





3T3 cell double minute 2

20848
954
NM_017343

ESTs, Highly similar to A37100 myosin regulatory light chain A, smooth muscle - rat
GENERAL, G, K





[ R. norvegicus ], RIKEN cDNA 2900073G15 gene, myosin light chain, phosphorylatable,





cardiac ventricles, myosin regulatory light chain, myosin, light polypeptide, regulatory,





non-sarcomeric (20 kD)

20849
954
NM_017343

ESTs, Highly similar to A37100 myosin regulatory light chain A, smooth muscle - rat
GENERAL, G, K





[ R. norvegicus ], RIKEN cDNA 2900073G15 gene, myosin light chain, phosphorylatable,





cardiac ventricles, myosin regulatory light chain, myosin, light polypeptide, regulatory,





non-sarcomeric (20 kD)

4198
814
M83143

ESTs, Highly similar to A41734 beta-galactoside alpha-2,6-sialyltransferase [ H. sapiens ],
GENERAL, I





sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase), sialyltransferase 1 (beta-





galactoside alpha-2,6-sialytransferase)

4199
814
M83143

ESTs, Highly similar to A41734 beta-galactoside alpha-2,6-sialyltransferase [ H. sapiens ],
GENERAL





sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase), sialyltransferase 1 (beta-





galactoside alpha-2,6-sialytransferase)

6290
571
AI169232

ESTs, Highly similar to ANK1 MOUSE ANKYRIN 1 [ M. musculus ], ESTs, Weakly similar
C





to ANK1 MOUSE ANKYRIN 1 [ M. musculus ], GASZ, Gasz, Homo sapiens cDNA





FLJ25053 fis, clone CBL04266, Mus musculus ankyrin repeat domain-containing SOCS





box protein Asb-16 mRNA, complete cds, Mus musculus , Similar to hypothetical protein





DKFZp564O043, clone MGC: 36949 IMAGE: 4946879, mRNA, complete cds, RIKEN





cDNA 1110058D09 gene, RIKEN cDNA 4933400N19 gene, hypothetical protein similar to





ankyrin repeat-containing priotein AKR1, likely homolog of rat kinase D-interacting





substance of 220 kDa, regulatory factor X-associated ankyrin-containing protein

20682
1028
NM_022952

ESTs, Highly similar to AP19_HUMAN CLATHRIN COAT ASSEMBLY PROTEIN AP19
B





[ H. sapiens ], ESTs, Highly similar to clathrin-associated protein AP17 delta [ H. sapiens ],





ESTs, Weakly similar to A2S1_MOUSE Clathrin coat assembly protein AP17 (Clathrin





coat associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (HA2 17 kDa





subunit) (Clathrin assembly protein 2 small chain) [ R. norvegicus ], Homo sapiens ,





clone MGC: 17284 IMAGE: 4340257, mRNA, complete cds, adaptor-related protein





complex 2, sigma 1 subunit, expressed sequence AI043088

19235
441
AI045074

ESTs, Highly similar to BGAL MOUSE BETA-GALACTOSIDASE PRECURSOR
GENERAL





[ M. musculus ], RIKEN cDNA 2810025E10 gene, galactosidase, beta 1, hypothetical





protein BC008326, hypothetical protein BC011001

20753
1104
NM_031763

ESTs, Highly similar to CIA1_HUMAN WD40-REPEAT CONTAINING PROTEIN CIAO 1
GENERAL, C, I





[ H. sapiens ], ESTs, Weakly similar to LIS1_HUMAN PLATELET-ACTIVATING FACTOR





ACETYLHYDROLASE IB ALPHA SUBUNIT [ H. sapiens ], ESTs, Weakly similar to





LIS1_MOUSE Platelet-activating factor acetylhydrolase IB alpha subunit (PAF





acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH





alpha) (Lissencephaly-1 protein) (LIS-1) [ R. norvegicus ], F-box and WD-40 domain protein





7 (archipelago homolog, Drosophila ), Homo sapiens cDNA FLJ31861 fis, clone





NT2RP7001319, KIAA0007 protein, MEP50 protein, Mus musculus F-box-WD40 repeat





protein 6 (Fbxw6) mRNA, complete cds, Mus musculus , Similar to RIKEN cDNA





1500041N16 gene, clone MGC: 12066 IMAGE: 3708188, mRNA, complete cds,





hypothetical protein FLJ11848, hypothetical protein similar to beta-transducin family,





platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit, platelet-activating





factor acetylhydrolase, isoform lb, alpha subunit (45 kD)

13954
1168
NM_053955

ESTs, Highly similar to CRYM_HUMAN MU-CRYSTALLIN HOMOLOG [ H. sapiens ],
GENERAL





crystallin, mu

17570
626
AI177683

ESTs, Highly similar to DDRT helix-destabilizing protein - rat [ R. norvegicus ], ESTs,
C, E





Highly similar to ROA3_HUMAN HETEROGENEOUS NUCLEAR





RIBONUCLEOPROTEIN A3 [ H. sapiens ], ESTs, Highly similar to S12520 core protein A1





[ H. sapiens ], ESTs, Highly similar to heterogeneous ribonuclear particle protein A1





[ H. sapiens ], ESTs, Moderately similar to heterogeneous ribonuclear particle protein A1





[ H. sapiens ], ESTs, Weakly similar to ROA2 MOUSE HETEROGENEOUS NUCLEAR





RIBONUCLEOPROTEINS A2/B1 [ M. musculus ], Mus musculus , similar to heterogeneous





nuclear ribonucleoprotein A3 (H. sapiens), clone MGC: 37309 IMAGE: 4975085, mRNA,





complete cds, RIKEN cDNA 2610510D13 gene, RIKEN cDNA 3010025E17 gene,





heterogeneous nuclear ribonucleoprotein A1, heterogeneous nuclear ribonucleoprotein





A2/B1, heterogeneous nuclear ribonucleoprotein A3, hypothetical protein 23851

2242
1138
NM_053433

ESTs, Highly similar to FMO3_HUMAN DIMETHYLANILINE MONOOXYGENASE
GENERAL, H, I, J





[ H. sapiens ], ESTs, Weakly similar to FMO3_HUMAN DIMETHYLANILINE





MONOOXYGENASE [ H. sapiens ], Mus musculus flavin-containing monooxygenase 4





mRNA, complete cds, flavin containing monooxygenase 2, flavin containing





monooxygenase 3, flavin containing monooxygenase 5

1546
1231
U85512

ESTs, Highly similar to GFRP RAT GTP CYCLOHYDROLASE I FEEDBACK
GENERAL, G





REGULATORY PROTEIN [ R. norvegicus ], GTP cyclohydrolase I feedback regulatory





protein

24211
540
AI111853

ESTs, Highly similar to H33_HUMAN HISTONE H3.3 [ H. sapiens ], H3 histone, family 3A,
G





H3 histone, family 3B, H3 histone, family 3B (H3.3B), RIKEN cDNA 1810027O10 gene

15642
1172
NM_053985

ESTs, Highly similar to H33_HUMAN HISTONE H3.3 [ H. sapiens ], H3 histone, family 3A,
GENERAL, F, J





H3 histone, family 3B, H3 histone, family 3B (H3.3B), RIKEN cDNA 1810027O10 gene

19110
872
NM_012963

ESTs, Highly similar to HMG1_HUMAN HIGH MOBILITY GROUP PROTEIN HMG1
A, J





[ H. sapiens ], ESTs, Moderately similar to HMG1 MOUSE HIGH MOBILITY GROUP





PROTEIN HMG1 [ M. musculus ], ESTs, Moderately similar to high mobility group protein





homolog HMG4 [ M. musculus ], ESTs, Weakly similar to HMG1_HUMAN HIGH MOBILITY





GROUP PROTEIN HMG1 [ H. sapiens ], RIKEN cDNA 4932431P20 gene, Rattus





norvegicus epidermal Langerhans cell protein LCP1 mRNA, complete cds, high mobility





group 20A, high mobility group box 1, high-mobility group (nonhistone chromosomal)





protein 1 high-mobility group 20A

19433
57
AA819776

ESTs, Highly similar to HS9A_HUMAN HEAT SHOCK PROTEIN HSP 90-ALPHA
H





[ H. sapiens ], ESTs, Highly similar to HS9B_RAT Heat shock protein HSP 90-beta (HSP





84) [ R. norvegicus ], ESTs, Highly similar to T46243 hypothetical protein





DKFZp761K0511.1 [ H. sapiens ], Mus musculus , clone IMAGE: 3584589, mRNA, partial





cds, expressed sequence C81438, heat shock 90 kD protein 1, beta, heat shock protein,





84 kDa 1, heat shock protein, 86 kDa 1

20795
253
AA944397

ESTs, Highly similar to HS9B_RAT Heat shock protein HSP 90-beta (HSP 84)
H





[ R. norvegicus ], ESTs, Highly similar to T46243 hypothetical protein DKFZp761K0511.1





[ H. sapiens ], Mus musculus , clone IMAGE: 3584589, mRNA, partial cds, expressed





sequence C81438, heat shock 90 kD protein 1 beta, heat shock protein, 84 kDa 1, heat





shock protein, 86 kDa 1

16518
612
AI176546

ESTs, Highly similar to HS9B_RAT Heat shock protein HSP 90-beta (HSP 84)
C, K





[ R. norvegicus ], ESTs, Highly similar to T46243 hypothetical protein DKFZp761K0511.1





[ H. sapiens ], Mus musculus , clone IMAGE: 3584589, mRNA, partial cds, expressed





sequence C81438, heat shock 90 kD protein 1, beta, heat shock protein, 84 kDa 1, heat





shock protein, 86 kDa 1

67
1085
NM_031605

ESTs, Highly similar to I65981 fatty acid omega-hydroxylase [ H. sapiens ], Homo sapiens ,
B





Similar to cytochrome P450, subfamily IVA, polypeptide 11, clone MGC: 22151





IMAGE: 4072062, mRNA, complete cds, Mus musculus , Similar to cytochrome P450,





4a10, clone MGC: 18880 IMAGE: 4237837, mRNA, complete cds, Mus musculus , Similar





to cytochrome P450, 4a10, clone MGC: 25972 IMAGE: 4240359, mRNA, complete cds,





RIKEN cDNA A230105L22 gene, cytochrome P450, 4a10, expressed sequence





AI314743

11840
1258
Y15068

ESTs, Highly similar to IEFS_HUMAN TRANSFORMATION-SENSITIVE PROTEIN IEF
H, I





SSP 3521 [ H. sapiens ], ESTs, Weakly similar to small glutamine-rich tetratricopeptide





repeat (TPR) containing protein (SGT) [ Rattus norvegicus ] [ R. norvegicus ], Mus





musculus , clone MGC: 27660 IMAGE: 4527683, mRNA, complete cds, RIKEN cDNA





5330427H01 gene, hypothetical protein FLJ12788, small glutamine-rich tetratricopeptide





repeat (TPR) containing protein (SGT), small glutamine-rich tetratricopeptide repeat





(TPR)-containing, stress-induced phosphoprotein 1, stress-induced-phosphoprotein 1





(Hsp70/Hsp90-organizing protein)

9067
460
AI070087

ESTs, Highly similar to IF34 MOUSE EUKARYOTIC TRANSLATION INITIATION
GENERAL





FACTOR 3 SUBUNIT 4 [ M. musculus ], ESTs, Moderately similar to NUCLEOLIN





[ M. musculus ], ESTs, Weakly similar to NUCL_HUMAN NUCLEOLIN [ H. sapiens ],





Nucleolin, RIKEN cDNA 0610008K04 gene, eukaryotic translation initiation factor 3,





subunit 4 (delta, 44 kDa), eukaryotic translation initiation factor 3, subunit 4 (delta, 44 kD),





nucleolin, pigpen

1764
1171
NM_053974

ESTs, Highly similar to IF4E_HUMAN EUKARYOTIC TRANSLATION INITIATION
C





FACTOR 4E [ H. sapiens ], RIKEN cDNA 1300018P11 gene, RIKEN cDNA 2700069E09





gene, eukaryotic translation initiation factor 4E, eukaryotic translation initiation factor 4E-





like 3

21659
382
AI010584

ESTs, Highly similar to IFM3_HUMAN INTERFERON-INDUCED TRANSMEMBRANE
D





PROTEIN 3 [ H. sapiens ], ESTs, Highly similar to S17182 interferon-induced protein 1-8 U





[ H. sapiens ], RIKEN cDNA 1110004C05 gene, interferon induced transmembrane protein





1 (9-27), interferon induced transmembrane protein 3 (1-8 U)

21657
1247
X61381

ESTs, Highly similar to IFM3_HUMAN INTERFERON-INDUCED TRANSMEMBRANE
GENERAL





PROTEIN 3 [ H. sapiens ], ESTs, Highly similar to S17182 interferon-induced protein 1-8 U





[ H. sapiens ], RIKEN cDNA 1110004C05 gene, interferon induced transmembrane protein





1 (9-27), interferon induced transmembrane protein 3 (1-8 U)

3016
37
AA818069

ESTs, Highly similar to JE0190 polyubiquitin unit [ H. sapiens ], ESTs, Highly similar to
H





UQHUC polyubiquitin 9 [ H. sapiens ], Homo sapiens , Similar to orosomucoid 1, clone





MGC: 24263 IMAGE: 3934516, mRNA, complete cds, expressed sequence AL033289,





ubiquitin B, ubiquitin C

3015
779
D16554

ESTs, Highly similar to JE0190 polyubiquitin unit [ H. sapiens ], ESTs, Highly similar to
A





UQHUC polyubiquitin 9 [ H. sapiens ], Homo sapiens , Similar to orosomucoid 1, clone





MGC: 24263 IMAGE: 3934516, mRNA, complete cds, expressed sequence AL033289,





ubiquitin B, ubiquitin C

825
270
AA946108

ESTs, Highly similar to LMA3 MOUSE LAMININ ALPHA-3 CHAIN PRECURSOR
GENERAL, A





[ M. musculus ], Laminin chain beta 2, expressed sequence AW211941, expressed





sequence C80098, laminin, alpha 3, laminin, alpha 3 (nicein (150 kD), kalinin (165 kD),





BM600 (150 kD), epilegrin), laminin, beta 2, laminin, beta 2 (laminin S)

18070
898
NM_013160

ESTs, Highly similar to MXI1_RAT MAX interacting protein 1 (MXI1 protein)
GENERAL





[ R. norvegicus ], ESTs, Moderately similar to MXI1_RAT MAX interacting protein 1 (MXI1





protein) [ R. norvegicus ], ESTs, Weakly similar to MXI1_RAT MAX interacting protein 1





(MXI1 protein) [ R. norvegicus ], MAX dimerization protein, MAX interacting protein 1, Max





interacting protein 1

3467
756
AI237835

ESTs, Highly similar to MXI1_RAT MAX interacting protein 1 (MXI1 protein)
GENERAL, I





[ R. norvegicus ], ESTs, Weakly similar to MXI1_RAT MAX interacting protein 1 (MXI1





protein) [ R. norvegicus ], MAX dimerization protein, MAX interacting protein 1, Max





interacting protein 1

3465
898
NM_013160

ESTs, Highly similar to MXI1_RAT MAX interacting protein 1 (MXI1 protein)
GENERAL, B, F





[ R. norvegicus ], ESTs, Weakly similar to MXI1_RAT MAX interacting protein 1 (MXI1





protein) [ R. norvegicus ], MAX dimerization protein, MAX interacting protein 1, Max





interacting protein 1

1970
900
NM_013194

ESTs, Highly similar to MYH9_RAT Myosin heavy chain, nonmuscle type A (Cellular
K





myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A)





[ R. norvegicus ], ESTs, Highly similar to MYHA_MOUSE Myosin heavy chain, nonmuscle





type B (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B)





(NMMHC-B) [ M. musculus ], ESTs, Weakly similar to MYH9_RAT Myosin heavy chain,





nonmuscle type A (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-





A) (NMMHC-A) [ R. norvegicus ], ESTs, Weakly similar to MYHA_MOUSE Myosin heavy





chain, nonmuscle type B (Cellular myosin heavy chain, type B) (Nonmuscle myosin





heavy chain-B) (NMMHC-B) [ M. musculus ], RIKEN cDNA 2400004E04 gene, RIKEN





cDNA 5730504C04 gene, TGFB1-induced anti-apoptotic factor 1, myosin heavy chain IX,





myosin, heavy polypeptide 9, non-muscle, protein tyrosine phosphatase, receptor-type, F





interacting protein, binding protein 2

18011
1082
NM_031588

ESTs, Highly similar to NRG2_MOUSE PRO-NEUREGULIN-2 PRECURSOR (PRO-
GENERAL, H





NRG2) [CONTAINS: NEUREGULIN-2 (NRG-2) (DIVERGENT OF NEUREGULIN 1)





(DON-1)] [ M. musculus ], ESTs, Weakly similar to NRG2_MOUSE PRO-NEUREGULIN-2





PRECURSOR (PRO-NRG2) [CONTAINS: NEUREGULIN-2 (NRG-2) (DIVERGENT OF





NEUREGULIN 1) (DON-1)] [ M. musculus ], neuregulin 1

1141
1007
NM_022401

ESTs, Highly similar to PLE1_MOUSE PLECTIN 1 (PLTN) (PCN) [ M. musculus ], ESTs,
GENERAL, C, G





Weakly similar to plectin [ Rattus norvegicus ] [ R. norvegicus ], KIAA1009 protein, Mus





musculus , clone IMAGE: 4188338, mRNA, partial cds, desmoplakin (DPI, DPII),





expressed sequence AA407888, plectin 1, intermediate filament binding protein, 500 kD

472
780
D26111

ESTs, Highly similar to putative basolateral mTAL chloride channel CIC-Ka [ M. musculus ],
G





chloride channel 2, chloride channel K1-like, chloride channel Ka

4445
602
AI175466

ESTs, Highly similar to RASH_RAT TRANSFORMING PROTEIN P21/H-RAS-1 (C-H-
G





RAS) [ R. norvegicus ], Harvey rat sarcoma oncogene, subgroup R, Harvey rat sarcoma





virus oncogene, Mus musculus , Similar to v-Ha-ras Harvey rat sarcoma viral oncogene





homolog, clone MGC: 19390 IMAGE: 3152667, mRNA, complete cds, related RAS viral (r-





ras) oncogene homolog, v-Ha-ras Harvey rat sarcoma viral oncogene homolog

18741
107
AA874859

ESTs, Highly similar to S12207 hypothetical protein [ M. musculus ], ESTs, Highly similar to
GENERAL





S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ], ESTs, Moderately similar





to S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ], RIKEN cDNA





1110046J11 gene, neural precursor cell expressed, developmentally down-regulated 4,





neural precursor cell expressed, developmentally down-regulated gene 4a

12016
158
AA892404

ESTs, Highly similar to S12207 hypothetical protein [ M. musculus ], ESTs, Highly similar to
C





S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ], ESTs, Moderately similar





to S70642 ubiquitin ligase Nedd4 - rat (fragment) [ R. norvegicus ], RIKEN cDNA





1110046J11 gene, neural precursor cell expressed, developmentally down-regulated 4,





neural precursor cell expressed, developmentally down-regulated gene 4a

5601
700
AI232461

ESTs, Highly similar to S29125 dimethylaniline monooxygenase [ H. sapiens ], ESTs,
GENERAL, I





Weakly similar to S33758 flavin-containing monooxygenase 1 - rat [ R. norvegicus ], Flavin-





containing monooxygenase 1, Mus musculus flavin-containing monooxygenase 4 mRNA,





complete cds, expressed sequence AW107733, flavin containing monooxygenase 1,





flavin containing monooxygenase 3, flavin containing monooxygenase 4

18678
685
AI231295

ESTs, Highly similar to SM4F_HUMAN SEMAPHORIN 4F PRECURSOR [ H. sapiens ],
L





sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain,





sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short





cytoplasmic domain, (semaphorin) 4B, sema domain, immunoglobulin domain (Ig),





transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D, sema





domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic





domain (semaphorin) 4F

17771
42
AA818224

ESTs, Highly similar to T08726 tubulin beta chain [ H. sapiens ], ESTs, Highly similar to
GENERAL





TBB1_RAT TUBULIN BETA CHAIN (T BETA-15) [ R. norvegicus ], ESTs, Highly similar to





TBB2_HUMAN TUBULIN BETA-2 CHAIN [ H. sapiens ], RIKEN cDNA 2410129E14 gene,





RIKEN cDNA 4930447K03 gene, RIKEN cDNA 4930542G03 gene, expressed sequence





AI451582, expressed sequence C79445, tubulin beta-5, tubulin, beta 3

18361
12
AA799591

ESTs, Highly similar to T08726 tubulin beta chain [ H. sapiens ], ESTs, Highly similar to
GENERAL





TBB1_RAT TUBULIN BETA CHAIN (T BETA-15) [ R. norvegicus ], ESTs, Highly similar to





TBB2_HUMAN TUBULIN BETA-2 CHAIN [ H. sapiens ], RIKEN cDNA 2410129E14 gene,





RIKEN cDNA 4930447K03 gene, RIKEN cDNA 4930542G03 gene, Rat mRNA for beta-





tubulin T beta15, expressed sequence AI451582, expressed sequence C79445, tubulin





beta-5, tubulin, beta 3, tubulin, beta 2

19412
66
AA849222

ESTs, Highly similar to T46904 hypothetical protein DKFZp761D081.1 [ H. sapiens ], Homo
D





sapiens cDNA: FLJ21587 fis, clone COL06946, likely ortholog of mouse Arkadia

14121
1202
S82383

ESTs, Highly similar to TPMN_HUMAN TROPOMYOSIN, CYTOSKELETAL TYPE
I





[ H. sapiens ], ESTs, Moderately similar to TROPOMYOSIN 5, CYTOSKELETAL TYPE





[ M. musculus ]

13563
718
AI233773

ESTs, Highly similar to ULA4_HUMAN MAWD binding protein (Unknown protein 32 from
E





2D-page of liver tissue) [ H. sapiens ], MAWD binding protein

1410
1126
NM_052798

ESTs, Moderately similar to hypothetical protein MGC2663 [ Homo sapiens ] [ H. sapiens ],
H





ESTs, Moderately similar to S47073 finger protein HZF2, Krueppel-related [ H. sapiens ],





ESTs, Weakly similar to TC17 MOUSE TRANSCRIPTION FACTOR 17 [ M. musculus ],





ESTs, Weakly similar to TC17_RAT Zinc finger protein 354A (Transcription factor 17)





(Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally regulated





protein-1) [ R. norvegicus ], expressed sequence AI875089, hypermethylated in cancer 2,





zinc finger protein 354A, zinc finger protein 354B

9541
1015
NM_022542

ESTs, Moderately similar to rhoB gene [ Rattus norvegicus ] [ R. norvegicus ], ESTs,
L





Weakly similar to rhoB gene [ Rattus norvegicus ] [ R. norvegicus ], Mus musculus , clone





MGC: 29297 IMAGE: 5003249, mRNA, complete cds, RIKEN cDNA 5830400A04 gene,





ras homolog B (RhoB), ras homolog gene family, member B

24438
817
M85183

ESTs, Moderately similar to ribonuclease/angiogenin inhibitor 2 [ Mus musculus ]
GENERAL, F, L





[ M. musculus ], Homo sapiens , clone MGC: 40117 IMAGE: 5212737, mRNA, complete cds,





PYRIN-containing APAF1-like protein 5, apoptosis-associated speck-like protein





containing a CARD, cold autoinflammatory syndrome 1, death effector filament-forming





Ced-4-like apoptosis protein, expressed sequence AI504961, ribonuclease/angiogenin





inhibitor 2

17401
881
NM_013043

ESTs, Moderately similar to DIP_HUMAN DIP PROTEIN [ H. sapiens ], KIAA0669 gene
GENERAL, B, G





product, RIKEN cDNA 0610009M14 gene, RIKEN cDNA 1810043J12 gene, TSC-22-like,





transforming growth factor beta 1 induced transcript 4, transforming growth factor beta-





stimulated protein TSC-22

16718
538
AI111537

ESTs, Moderately similar to HB2D_RAT RT1 CLASS II HISTOCOMPATIBILITY
H





ANTIGEN, D-1 BETA CHAIN PRECURSOR [ R. norvegicus ], ESTs, Weakly similar to





HB2D_RAT RT1 CLASS II HISTOCOMPATIBILITY ANTIGEN, D-1 BETA CHAIN





PRECURSOR [ R. norvegicus ], Rattus norvegicus Class II MHC RT1.D(a) beta chain





precursor (RT1.D(a)) mRNA, complete cds, Rattus norvegicus Class II MHC RT1.D(n)





beta chain precursor (RT1.D(n)) mRNA, complete cds, histocompatibility 2, class II





antigen E beta, major histocompatibility complex, class II, DR beta 1, major





histocompatibility complex class II DR beta 5

22386
27
AA800844

ESTs, Moderately similar to LYOX_HUMAN PROTEIN-LYSINE 6-OXIDASE
F





PRECURSOR [ H. sapiens ], ESTs, Weakly similar to LYOX_RAT Protein-lysine 6-oxidase





precursor (Lysyl oxidase) [ R. norvegicus ], Lysyl oxidase, lysyl oxidase, lysyl oxidase-like,





lysyl oxidase-like 1, lysyl oxidase-like 2

8829
845
NM_012749

ESTs, Moderately similar to NUCLEOLIN [ M. musculus ], ESTs, Weakly similar to A35804
GENERAL, A, F, K





nucleolin [ H. sapiens ], ESTs, Weakly similar to NUCL_HUMAN NUCLEOLIN [ H. sapiens ],





ESTs, Weakly similar to NUCL_RAT Nucleolin (Protein C23) [ R. norvegicus ], RIKEN





cDNA 1200009A02 gene, eukaryotic translation initiation factor 3, subunit 4 (delta, 44 KDa),





nucleolin, pigpen

17477
1181
NM_057194

ESTs, Moderately similar to PLS1_RAT Phospholipid scramblase 1 (PL scramblase 1)
GENERAL, K, L





(Ca2+ dependent phospholipid scramblase 1) [ R. norvegicus ], ESTs, Weakly similar to





PLS1_RAT Phospholipid scramblase 1 (PL scramblase 1) (Ca2+ dependent phospholipid





scramblase 1) [ R. norvegicus ], phospholipid scramblase 1, phospholipid scramblase 2

1884
783
D50695

ESTs, Moderately similar to PRS6_HUMAN 26S PROTEASE REGULATORY SUBUNIT
I





6B [ H. sapiens ], proteasome (prosome, macropain) 26S subunit, ATPase, 4

6321
496
AI101256

ESTs, Moderately similar to S09017 heterogeneous ribonuclear particle protein type C -
GENERAL





rat (fragment) [ R. norvegicus ], Homo sapiens cDNA FLJ32918 fis, clone TESTI2006588,





Homo sapiens , clone IMAGE: 3450973, mRNA, Mus musculus , clone MGC: 36467





IMAGE: 5359082, mRNA, complete cds, heterogeneous nuclear ribonucleoprotein D, high-





glycine/tyrosine protein type I E5, musashi homolog 2 ( Drosophila )

1453
1165
NM_053887

ESTs, Moderately similar to S12207 hypothetical protein [ M. musculus ], ESTs, Weakly
F, K





similar to mitogen activated protein kinase kinase kinase 1 [ Rattus norvegicus ]





[ R. norvegicus ], mitogen activated protein kinase kinase kinase 1, mitogen activated





protein kinase kinase kinase 2, mitogen activated protein kinase kinase kinase 3, mitogen





activated protein kinase kinase kinase 1, mitogen-activated protein kinase kinase kinase 3

1454
1165
NM_053887

ESTs, Moderately similar to S12207 hypothetical protein [ M. musculus ], ESTs, Weakly
GENERAL, K





similar to mitogen activated protein kinase kinase kinase 1 [ Rattus norvegicus ]





[ R. norvegicus ], mitogen activated protein kinase kinase kinase 1, mitogen activated





protein kinase kinase kinase 2, mitogen activated protein kinase kinase kinase 3, mitogen





activated protein kinase kinase kinase 1, mitogen-activated protein kinase kinase kinase 3

2439
970
NM_019277

ESTs, Moderately similar to T09221 exocyst complex protein Sec15 - rat [ R. norvegicus ],
A, F





Homo sapiens rsec15-like protein mRNA, partial cds, Mus musculus , Similar to SEC15





( S. cerevisiae )-like, clone MGC: 30428 IMAGE: 2631201, mRNA, complete cds, RIKEN





cDNA 4930569O18 gene, SEC15 ( S. cerevisiae )-like, SEC15 homolog ( S. cerevisiae ),





Sec15B protein

22596
277
AA955298

ESTs, Moderately similar to T46637 transcription factor 1, neural - rat [ R. norvegicus ],
GENERAL





ESTs, Weakly similar to A35804 nucleolin [ H. sapiens ], Homo sapiens mRNA; cDNA





DKFZp434E0922 (from clone DKFZp434E0922), Mus musculus 10, 11 days embryo





whole body cDNA, RIKEN full-length enriched library, clone: 2810003I18: myelin





transcription factor 1-like, full insert sequence, myelin transcription factor 1-like, nucleolin

14346
1075
NM_031533

ESTs, Moderately similar to UDB5 MOUSE UDP-GLUCURONOSYLTRANSFERASE
B, H





2B5 PRECURSOR, MICROSOMAL [ M. musculus ], Mus musculus , Similar to UDP





glycosyltransferase 2 family, polypeptide B4, clone MGC: 37823 IMAGE: 5098890, mRNA,





complete cds, RIKEN cDNA 1300012D20 gene, UDP glycosyltransferase 2 family,





polypeptide B17, UDP-glucuronosyltransferase 2 family, member 5, expressed sequence





AA986709

14633
1075
NM_031533

ESTs, Moderately similar to UDB5 MOUSE UDP-GLUCURONOSYLTRANSFERASE
H





2B5 PRECURSOR, MICROSOMAL [ M. musculus ], Mus musculus , Similar to UDP





glycosyltransferase 2 family, polypeptide B4, clone MGC: 37823 IMAGE: 5098890, mRNA,





complete cds, RIKEN cDNA 1300012D20 gene, UDP glycosyltransferase 2 family,





polypeptide B17, UDP-glucuronosyltransferase 2 family, member 5, expressed sequence





AA986709

14347
1075
NM_031533

ESTs, Moderately similar to UDB5 MOUSE UDP-GLUCURONOSYLTRANSFERASE
H





2B5 PRECURSOR, MICROSOMAL [ M. musculus ], Mus musculus , Similar to UDP





glycosyltransferase 2 family, polypeptide B4, clone MGC: 37823 IMAGE: 5098890, mRNA,





complete cds, RIKEN cDNA 1300012D20 gene, UDP glycosyltransferase 2 family,





polypeptide B17, UDP-glucuronosyltransferase 2 family, member 5, expressed sequence





AA986709

17805
1117
NM_031980

ESTs, Moderately similar to UDB5 MOUSE UDP-GLUCURONOSYLTRANSFERASE
B





2B5 PRECURSOR, MICROSOMAL [ M. musculus ], Mus musculus , Similar to UDP





glycosyltransferase 2 family, polypeptide B4, clone MGC: 37823 IMAGE: 5098890, mRNA,





complete cds, RIKEN cDNA 1300012D20 gene, UDP glycosyltransferase 2 family,





polypeptide B17, UDP-glucuronosyltransferase 2 family, member 5, expressed sequence





AA986709

1537
1216
U27518

ESTs, Moderately similar to UDB5 MOUSE UDP-GLUCURONOSYLTRANSFERASE
H





2B5 PRECURSOR, MICROSOMAL [ M. musculus ], Mus musculus , Similar to UDP





glycosyltransferase 2 family, polypeptide B4, clone MGC: 37823 IMAGE: 5098890, mRNA,





complete cds, RIKEN cDNA 1300012D20 gene, UDP glycosyltransferase 2 family,





polypeptide B17, UDP-glucuronosyltransferase 2 family, member 5, expressed sequence





AA986709

15904
414
AI013971

ESTs, Weakly similar to L1 cell adhesion molecule [ Mus musculus ] [ M. musculus ], ESTs,
F





Weakly similar to A41060 neural cell adhesion molecule L1 precursor [ H. sapiens ], ESTs,





Weakly similar to S36126 neural cell adhesion molecule L1 - rat [ R. norvegicus ], L1 cell





adhesion molecule, L1 cell adhesion molecule (hydrocephalus, stenosis of aqueduct of





Sylvius 1, MASA (mental retardation, aphasia, shuffling gait and adducted thumbs)





syndrome, spastic paraplegia 1), close homolog of L1, neuronal cell adhesion molecule

20780
1017
NM_022590

ESTs, Weakly similar to low affinity Na-dependent glucose transporter (SGLT2) [ Rattus
GENERAL, D





norvegicus ] [ R. norvegicus ], Mus musculus , Similar to hypothetical protein FLJ13868,





clone MGC: 28903 IMAGE: 4919869, mRNA, complete cds, low affinity sodium-dependent





glucose cotransporter, solute carrier family 5 (sodium/glucose cotransporter), member 2,





solute carrier family 5, member 1

6641
1012
NM_022533

ESTs, Weakly similar to plasmolipin [ Rattus norvegicus ] [ R. norvegicus ], ESTs, Weakly
GENERAL, A, I





similar to PLLP_HUMAN PLASMOLIPIN [ H. sapiens ], Mus musculus , Similar to BENE





protein, clone MGC: 19097 IMAGE: 4205488, mRNA, complete cds, Mus musculus , clone





IMAGE: 4022528, mRNA, RIKEN cDNA 0610010I06 gene, RIKEN cDNA 2700018N07





gene, expressed sequence D19397, myelin and lymphocyte protein, T-cell differentiation





protein, plasmolipin

18246
1003
NM_022300

ESTs, Weakly similar to Ser/Arg-related nuclear matrix protein; plenty-of-prolines-101;
B, F





serine/arginine repetitive matrix protein 1 [ Mus musculus ] [ M. musculus ], Mus musculus ,





Similar to hypothetical protein MGC13125, clone MGC: 38070 IMAGE: 5252666, mRNA,





complete cds, brain abundant, membrane attached signal protein 1, expressed sequence





AI480556, glucocorticoid-induced gene 1, serine/arginine repetitive matrix 1

5711
442
AI045151

ESTs, Weakly similar to solute carrier family 25 (carnitine/acylcarnitine translocase),
GENERAL





member 20 [ Rattus norvegicus ] [ R. norvegicus ], KIAA0446 gene product, Mus musculus ,





Similar to CG4995 gene product, clone MGC: 7958 IMAGE: 3584570, mRNA, complete





cds, RIKEN cDNA 1300006L01 gene, expressed sequence AW491445, hypothetical





protein FLJ13044, solute carrier family 25 (carnitine/acylcarnitine translocase), member





20, solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member





20, solute carrier family 25 (mitochondrial carrier), member 18, solute carrier family 25





(mitochondrial carrier, Aralar), member 12, solute carrier family 25 (mitochondrial carrier;





adenine nucleotide translocator), member 13, solute carrier family 25 (mitochondrial





oxodicarboxylate carrier), member 21, solute carrier family 25, (mitochondrial carrier),





member 18, solute carrier family 25, member 13 (citrin)

6416
1136
NM_053380

ESTs, Weakly similar to solute carrier family 34 (sodium phosphate), member 2; type II
GENERAL, K





sodium-dependent phosphate transporter 3b [ Homo sapiens ] [ H. sapiens ], solute carrier





family 34 (sodium phosphate), member 2

19768
1119
NM_031986

ESTs, Weakly similar to syntenin [ Rattus norvegicus ] [ R. norvegicus ], syndecan binding
GENERAL, C, G





protein, syndecan binding protein (syntenin), syndecan binding protein (syntenin) 2

1798
261
AA945569

ESTs, Weakly similar to A2MG MOUSE ALPHA-2-MACROGLOBULIN PRECURSOR
GENERAL, D





[ M. musculus ], Mus musculus GPI-anchored alpha-2 macroglobulin-related protein





mRNA, complete cds, alpha-2-macroglobulin

8426
338
AF036335

ESTs, Weakly similar to A54691 octamer-binding protein NonO - mouse [ M. musculus ],
E, F





ESTs, Weakly similar to PSF_HUMAN PTB-ASSOCIATED SPLICING FACTOR





[ H. sapiens ], RIKEN cDNA 9030402K04 gene, non-POU-domain-containing, octamer





binding protein, splicing factor proline/glutamine rich (polypyrimidine tract binding protein





associated)

3438
182
AA892921

ESTs, Weakly similar to A55143 calpain (EC 3.4.22.17) light chain - rat (fragment)
K





[ R. norvegicus ], Mus musculus , Similar to grancalcin, EF-hand calcium binding protein,





clone MGC: 29240 IMAGE: 5044040, mRNA, complete cds, RIKEN cDNA 2310005G05





gene, calpain, small subunit 1, programmed cell death 6, sorcin

15051
741
AI236332

ESTs, Weakly similar to ATDA_HUMAN DIAMINE ACETYLTRANSFERASE [ H. sapiens ],
GENERAL





RIKEN cDNA 2610016A03 gene, spermidine/spermine N1-acetyltransferase

10378
709
AI233300

ESTs, Weakly similar to CO5 MOUSE COMPLEMENT C5 PRECURSOR [ M. musculus ],
A





complement component 5, hemolytic complement

20832
268
AA946040

ESTs, Weakly similar to COXG MOUSE CYTOCHROME C OXIDASE POLYPEPTIDE
A





VIB [ M. musculus ], Homo sapiens , hypothetical gene LOC125965, clone MGC: 33640





IMAGE: 4827471, mRNA, complete cds

20833
524
AI104035

ESTs, Weakly similar to COXG MOUSE CYTOCHROME C OXIDASE POLYPEPTIDE
A





VIB [ M. musculus ], Homo sapiens , hypothetical gene LOC125965, clone MGC: 33640





IMAGE: 4827471, mRNA, complete cds

20716
984
NM_019623

ESTs, Weakly similar to CYP4B1 [ M. musculus ], RIKEN cDNA 1810054N16 gene,
G





cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase),





cytochrome P450, subfamily IVF, polypeptide 2, cytochrome P450, subfamily IVF,





polypeptide 8, expressed sequence AW108534, expressed sequence AW111961

21914
1257
Y13336

ESTs, Weakly similar to DAD1_HUMAN Defender against cell death 1 (DAD-1)
J





[ R. norvegicus ], defender against cell death 1

25070
1038
NM_024392

ESTs, Weakly similar to DHB4 MOUSE ESTRADIOL 17 BETA-DEHYDROGENASE 4
GENERAL





[ M. musculus ], ESTs, Weakly similar to DHB4_HUMAN ESTRADIOL 17 BETA-





DEHYDROGENASE 4 [ H. sapiens ], RIKEN cDNA 1110029G07 gene, RIKEN cDNA





1700010M22 gene, RIKEN cDNA 3110069K09 gene, hydroxysteroid (17-beta)





dehydrogenase 4

14083
619
AI177181

ESTs, Weakly similar to FYV1 MOUSE FYVE FINGER-CONTAINING
C





PHOSPHOINOSITIDE KINASE [ M. musculus ], MAD, mothers against decapentaplegic





homolog ( Drosophila ) interacting protein, receptor activation anchor, RIKEN cDNA





1110013H04 gene, myotubularin related protein 3, phosphatidylinositol-4-phosphate 5-





kinase, type III

20817
398
AI012589

ESTs, Weakly similar to GTP_RAT Glutathione S-transferase P (GST 7-7) (Chain 7)
GENERAL





(GST class-pi) [ R. norvegicus ], Mus musculus , clone MGC: 37914 IMAGE: 5102505,





mRNA, complete cds, glutathione S-transferase pi, glutathione S-transferase, pi 2

20818
1233
X02904

ESTs, Weakly similar to GTP_RAT Glutathione S-transferase P (GST 7-7) (Chain 7)
GENERAL





(GST class-pi) [ R. norvegicus ], Mus musculus , clone MGC: 37914 IMAGE: 5102505,





mRNA, complete cds, glutathione S-transferase pi, glutathione S-transferase, pi 2

11421
1190
NM_130405

ESTs, Weakly similar to I49140 p62 ras-GAP associated phosphoprotein - mouse
E





[ M. musculus ], Homo sapiens Sam68-like mammalian protein 1 (SLM1) mRNA, complete





cds, KH domain containing, RNA binding, signal transduction associated 1, homolog of





mouse quaking QKI (KH domain RNA binding protein), quaking

6630
594
AI172184

ESTs, Weakly similar to I53171 pantophysin [ H. sapiens ], RIKEN cDNA 1500003F20
F





gene, Synaptophysin, mitsugumin 29, pantophysin, synaptophysin, synaptophysin-like





protein

5952
298
AA963102

ESTs, Weakly similar to JC7328 amino acid transporter A1 [ H. sapiens ], Homo sapiens
E





clone 24674 mRNA sequence, solute carrier family 38, member 1, solute carrier family





38, member 2

17850
508
AI102750

ESTs, Weakly similar to JQ0866 T-complex protein 1 - rat [ R. norvegicus ], T-complex 1,
H





chaperonin containing TCP1, subunit 2 (beta), chaperonin containing TCP1, subunit 7





(eta), chaperonin subunit 2 (beta), chaperonin subunit 7 (eta), expressed sequence





AA408524, expressed sequence AL024346, t-complex protein 1

187
866
NM_012903

ESTs, Weakly similar to LANP_RAT Leucine-rich acidic nuclear protein [ R. norvegicus ],
F





acidic (leucine-rich) nuclear phosphoprotein 32 family, member A, acidic nuclear





phosphoprotein 32, cerebellar ataxia 3, hypothetical gene MGC16309, small nuclear





ribonucleoprotein polypeptide A′

24762
1139
NM_053442

ESTs, Weakly similar to LAT2_RAT Large neutral amino acids transporter small subunit 2
GENERAL, D





(L-type amino acid transporter 2) [ R. norvegicus ], solute carrier family 7 (cationic amino





acid transporter, y+ system), member 8

16003
1103
NM_031757

ESTs, Weakly similar to MM24_MOUSE MATRIX METALLOPROTEINASE-24
C





PRECURSOR (MMP-24) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE 5) (MT-





MMP 5) (MEMBRANE-TYPE-5 MATRIX METALLOPROTEINASE) (MT5-MMP) (MMP-





21) [ M. musculus ], matrix metalloproteinase 17, matrix metalloproteinase 19, matrix





metalloproteinase 24, matrix metalloproteinase 24 (membrane-inserted)

16147
1220
U51898

ESTs, Weakly similar to PA26_RAT 85 kDa calcium-independent phospholipase A2
GENERAL





(iPLA2) (Cal-PLA2) (Group VI phospholipase A2) (GVI PLA2) [ R. norvegicus ], Homo





sapiens cDNA FLJ10428 fis, clone NT2RP1000376, highly similar to Homo sapiens





mRNA; cDNA DKFZp434A102, RIKEN cDNA 2310026G15 gene, ankyrin repeat and





SOCS box-containing 13, ankyrin repeat and SOCS box-containing protein 1,





chromosome 20 open reading frame 86, phospholipase A2, group VI, phospholipase A2,





group VI (cytosolic, calcium-independent)

13609
161
AA892468

ESTs, Weakly similar to PSS8_RAT Prostasin precursor [ R. norvegicus ], RIKEN cDNA
GENERAL, H, I





1700112C13 gene, RIKEN cDNA 2010001P08 gene, marapsin, protease, serine, 8





(prostasin), tryptase gamma 1

13610
161
AA892468

ESTs, Weakly similar to PSS8_RAT Prostasin precursor [ R. norvegicus ], RIKEN cDNA
GENERAL, A, C, F, H, I, K





1700112C13 gene, RIKEN cDNA 2010001P08 gene, marapsin, protease, serine, 8





(prostasin), typtase gamma 1

13611
639
AI179378

ESTs, Weakly similar to PSS8_RAT Prostasin precursor [ R. norvegicus ], RIKEN cDNA
GENERAL, F, H,





1700112C13 gene, RIKEN cDNA 2010001P08 gene, marapsin, protease, serine, 8





(prostasin), tryptase gamma 1

7299
413
AI013911

ESTs, Weakly similar to RBM3 MOUSE PUTATIVE RNA-BINDING PROTEIN 3
GENERAL, A, B, L





[ M. musculus ], Mus musculus adult male tongue cDNA, RIKEN full-length enriched library,





clone: 2310074E15:RNA binding motif protein 3, full insert sequence, RNA binding motif





protein 3, RNA binding motif protein, X chromosome, RNA binding motif protein, X





chromosome retrogene, cold inducible RNA binding protein, cold inducible RNA-binding





protein

1475
1115
NM_031971

ESTs, Weakly similar to S10A MOUSE S-100 PROTEIN, ALPHA CHAIN [ M. musculus ],
C





S100 calcium binding protein A1, S100 calcium binding protein A11 (calizzarin), S100





calcium binding protein P, S100Z protein, expressed sequence AI266795

1472
1215
U26356

ESTs, Weakly similar to S10A MOUSE S-100 PROTEIN, ALPHA CHAIN [ M. musculus ],
K





S100 calcium binding protein A1, S100 calcium binding protein A11 (calizzarin), S100





calcium binding protein P, S100Z protein, expressed sequence AI266795

20886
886
NM_013097

ESTs, Weakly similar to S13676 deoxyribonuclease I (EC 3.1.21.1) - rat [ R. norvegicus ],
E, G





RIKEN cDNA 4733401H14 gene, deoxyinbonuclease I, deoxyribonuclease I-like 2

20887
886
NM_013097

ESTs, Weakly similar to S13676 deoxyribonuclease I (EC 3.1.21.1) - rat [ R. norvegicus ],
E, G





RIKEN cDNA 4733401H14 gene, deoxyribonuclease I, deoxyribonuclease I-like 2

13392
922
NM_017148

ESTs, Weakly similar to S53580 cysteine-rich protein - rat [ R. norvegicus ], RIKEN cDNA
GENERAL





0610025L06 gene, cysteine and glycine-rich protein 1, cysteine rich protein

20802
1018
NM_022592

ESTs, Weakly similar to TKT_HUMAN TRANSKETOLASE [ H. sapiens ], RIKEN cDNA
H





4933401I19 gene, hypothetical protein DKFZp434L1717, transketolase, transketolase





(Wernicke-Korsakoff syndrome), transketolase-like 1

20803
1018
NM_022592

ESTs, Weakly similar to TKT_HUMAN TRANSKETOLASE [ H. sapiens ], RIKEN cDNA
B, H, I





4933401I19 gene, hypothetical protein DKFZp434L1717, transketolase, transketolase





(Wernicke-Korsakoff syndrome), transketolase-like 1

20804
1018
NM_022592

ESTs, Weakly similar to TKT_HUMAN TRANSKETOLASE [ H. sapiens ], RIKEN cDNA
H





4933401I19 gene, hypothetical protein DKFZp434L1717, transketolase, transketolase





(Wernicke-Korsakoff syndrome), transketolase-like 1

11843
1143
NM_053555

ESTs, Weakly similar to VAM5_HUMAN VESICULE-ASSOCIATED MEMBRANE
A





PROTEIN 5 (VAMP-5) (MYOBREVIN) (HSPC191) [ H. sapiens ], vesicle-associated





membrane protein 5, vesicle-associated membrane protein 5 (myobrevin)

4592
979
NM_019356

eukaryotic translation initiation factor 2, subunit 1 (alpha, 35 kD), eukaryotic translation
H





initiation factor 2A

5481
647
AI180170

eukaryotic translation termination factor 1
GENERAL

12682
1069
NM_031332

expressed sequence AA986766, organic cationic transporter-like 4, reduced in
D





osteosclerosis transporter, solute carrier family 22 (organic anion transporter), member 8

17324
991
NM_021593

expressed sequence AI046660, kynurenine 3-monooxygenase (kynurenine 3-
GENERAL





hydroxylase)

7690
48
AA818875

expressed sequence AV066530, guanylate cyclase activator 2B (uroguanylin), guanylate
GENERAL





cyclase activator 2b (retina)

1809
274
AA946503

expressed sequence AW212229, lipocalin 2 (oncogene 24p3)
G, K

20740
1197
S69874

fatty acid binding protein 5 (psoriasis-associated), fatty acid binding protein 5, epidermal
D

13091
550
AI136977

FK506 binding protein 4 (59 kD), RIKEN cDNA 4930571K23 gene
L

13092
689
AI231547

FK506 binding protein 4 (59 kD), RIKEN cDNA 4930571K23 gene
L

23987
1238
X51615

gap junction protein, beta 2, 26 kD (connexin 26)
B

7451
420
AI029450

glutamyl-prolyl-tRNA synthetase
L

17325
22
AA800587

Glutathione peroxidase 1, glutathione peroxidase 1, glutathione peroxidase 2, glutathione
GENERAL, G, K





peroxidase 2 (gastrointestinal)

22675
980
NM_019358

glycoprotein 38, lung type-I cell membrane-associated glycoprotein
G

6675
36
AA817994

GTP-rho binding protein 1, RIKEN cDNA 1300002E07 gene, expressed sequence
C





BB023497, hypothetical protein FLJ22938, regulator of G-protein signaling 3, rhophilin-





like protein

14184
1106
NM_031776

guanine deaminase
GENERAL

14185
1106
NM_031776

guanine deaminase
GENERAL

13285
586
AI171361

heterogeneous nuclear ribonucleoprotein A0
A

8820
1186
NM_080399

HIF-1 responsive RTP801, Homo sapiens , Similar to RIKEN cDNA 1700037B15 gene,
B, H, L





clone MGC: 9960 IMAGE: 3877854, mRNA, complete cds

23282
1232
U90725

high density lipoprotein binding protein (vigilin)
A

3083
459
AI060150

HIRA interacting protein 3
E

3816
716
AI233729

Homo sapiens cDNA FLJ10203 fis, clone HEMBA1004930, moderately similar to 26S
H





PROTEASOME SUBUNIT S5B, proteasome (prosome, macropain) 26S subunit, non-





ATPase, 5

4944
218
AA924405

Homo sapiens cDNA FLJ11845 fis, clone HEMBA1006674, Mus musculus , Similar to
GENERAL, H, I, K





hypothetical protein FLJ10350, clone MGC: 27585 IMAGE: 4489521, mRNA, complete





cds, Mus musculus , Similar to neurofilament, heavy polypeptide (200 kD), clone





MGC: 32399 IMAGE: 5037953, mRNA, complete cds, nucleolar protein 5A (56 kD with





KKE/D repeat)

3941
386
AI011598

Homo sapiens cDNA FLJ14042 fis, clone HEMBA1006038, weakly similar to LAMININ
GENERAL, J





ALPHA-5 CHAIN, expressed sequence AA408762, expressed sequence AI853660,





laminin, alpha 5

8739
469
AI070859

Homo sapiens cDNA FLJ20166 fis, clone COL09511, KIAA0984 protein, KIAA1055
D





protein, TBC1 domain family, member 2, hypothetical protein FLJ22474

20896
1148
NM_053592

Homo sapiens cDNA FLJ25344 fis, clone TST01087, RIKEN cDNA 5031412I06 gene
A, F

24197
462
AI070314

Homo sapiens cDNA FLJ30453 fis, clone BRACE2009307, weakly similar to P120
B, L





PROTEIN, armadillo repeat gene deletes in velocardiofacial syndrome, catenin (cadherin-





associated protein), delta 2 (neural plakophilin-related arm-repeat protein), plakophilin 4

24900
925
NM_017163

Homo sapiens cDNA FLJ31236 fis, clone KIDNE2004828, moderately similar to Mus
H





musculus orphan transporter isoform A12 (Xtrp2) mRNA, RIKEN cDNA 4632401C08





gene, X transporter protein 2

7540
450
AI045882

Homo sapiens cDNA FLJ31665 fis, clone NT2RI2004606, Homo sapiens , clone
GENERAL, B, L





IMAGE: 4690662, mRNA

22592
410
AI013740

Homo sapiens cDNA FLJ31762 fis, clone NT2RI2007754, weakly similar to INTESTINAL
GENERAL, G, K





MEMBRANE A4 PROTEIN, hypothetical protein BC010116, hypothetical protein





BC013109

11164
735
AI235739

Homo sapiens cDNA FLJ31775 fis, clone NT2RI2008115, biphenyl hydrolase-like (serine
GENERAL, I





hydrolase; breast epithelial mucin-associated antigen)

22984
220
AA924560

Homo sapiens cDNA FLJ32770 fis, clone TESTI2001898, Homo sapiens mRNA; cDNA
E





DKFZp434I0121 (from clone DKFZp434I0121), fer-1-like 3, myoferlin ( C. elegans ), fer-1-





like 4 ( C. elegans )

7300
1070
NM_031341

Homo sapiens cDNA FLJ33031 fis, clone THYMU2000176, expressed sequence
C





AI643885, solute carrier family 7 (cationic amino acid transporter, y+ system), member 6,





solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

3615
754
AI237645

Homo sapiens mRNA; cDNA DKFZp434M2227 (from clone DKFZp434M2227), Homo
J





sapiens prostate-specific membrane antigen PSM mRNA, exon 6 alternative splice





variant, partial cds, RIKEN cDNA 2610028K12 gene, transferrin receptor, transferrin





receptor (p90, CD71), transferrin receptor 2

6518
391
AI012114

Homo sapiens mRNA; cDNA DKFZp547I147 (from clone DKFZp547I147), Homo
GENERAL





sapiens , Similar to hypothetical protein FLJ20244, clone MGC: 17561 IMAGE: 3463518,





mRNA, complete cds, chromosome 1 open reading frame 25, hypothetical protein





FLJ20244

23748
566
AI169037

Homo sapiens PP3958 mRNA, complete cds, Mus musculus , similar to MANNOSE-P-
F





DOLICHOL UTILIZATION DEFECT 1 PROTEIN HOMOLOG, clone MGC: 32303





IMAGE: 5025905, mRNA, complete cds, mannose-P-dolichol utilization defect 1

21211
1023
NM_022607

Homo sapiens , clone MGC: 12790 IMAGE: 4302265, mRNA, complete cds, NADH
C





dehydrogenase (ubiquinone) flavoprotein 3 (10 kD), nucleolar and coiled-body





phosphoprotein 1

8665
483
AI071965

Homo sapiens , clone MGC: 25063 IMAGE: 4480702, mRNA, complete cds
C

8664
1261
Z75029

Homo sapiens , clone MGC: 25063 IMAGE: 4480702, mRNA, complete cds
C, D

22569
646
AI179979

Homo sapiens , clone MGC: 26636 IMAGE: 4825619, mRNA, complete cds
GENERAL, I

20960
1020
NM_022598

Homo sapiens , Similar to RIKEN cDNA 4930513O09 gene, clone MGC: 33185
D





IMAGE: 5269882, mRNA, complete cds, Mus musculus , Similar to hypothetical protein





DKFZp761J139, clone MGC: 11924 IMAGE: 3599595, mRNA, complete cds, RIKEN





cDNA 4930513O09 gene, cellular nucleic acid binding protein, zinc finger protein 9 (a





cellular retroviral nucleic acid binding protein)

729
819
M95762

Homo sapiens , Similar to solute carrier family 6 (neurotransmitter transporter, GABA),
D





member 13, clone MGC: 24068 IMAGE: 4594185, mRNA, complete cds, Homo sapiens ,





clone MGC: 24098 IMAGE: 4612245, mRNA, complete cds, Mus musculus , Similar to





solute carrier family 6 (neurotransmitter transporter, GABA), member 13, clone





MGC: 28956 IMAGE: 4240641, mRNA, complete cds, expressed sequence AA589632

15986
1256
Y09945

Homo sapiens , Similar to ust3, clone MGC: 23972 IMAGE: 4714598, mRNA, complete
GENERAL, I





cds, Mus musculus , Similar to solute carrier family 22 (organic anion/cation transporter),





member 11, clone MGC: 31374 IMAGE: 4239636, mRNA, complete cds, Rattus





norvegicus mRNA for organic anion transporter 5, complete cds, expressed sequence





AA986766, expressed sequence AI648912, organic anion transporter 6, solute carrier





family 22 (organic anion transporter), member 6, solute carrier family 22 (organic cation





transporter)-like 2, ust3

18128
134
AA891800

hypothetical protein BC008246, inorganic pyrophosphatase, pyrophosphatase (inorganic)
I

15339
113
AA875171

hypothetical protein CAB56184
D

5369
567
AI169058

hypothetical protein CL25084
A

18168
247
AA942995

hypothetical protein DKFZp762N0610
E

2059
565
AI146005

hypothetical protein FKSG32, pseudouridine synthase 1, pseudouridylate synthase 1
A, H

2191
203
AA894086

hypothetical protein MGC17552
F

16982
894
NM_013144

insulin-like growth factor binding protein 1
GENERAL, B, L

23076
752
AI237388

interferon-related developmental regulator 1, interferon-related developmental regulator 2
K

16731
293
AA957244

JTV1 gene
D

5384
120
AA891041

Jun-B oncogene, jun B proto-oncogene
I

20161
998
NM_021836

Jun-B oncogene, jun B proto-oncogene
GENERAL, C, I

3053
320
AA997726

KIAA0185 protein
H

10069
452
AI058503

KIAA0247 gene product
F

17363
227
AA925150

KIAA0438 gene product, Mus musculus , clone IMAGE: 3499845, mRNA, partial cds,
F, K





goliath protein, hypothetical protein FLJ20552, hypothetical protein LOC51255, praja 1,





praja1, RING-H2 motif containing, rotein carrying the RING-H2 sequence motif, similar to





RIKEN cDNA 1300002C13, zinc finger protein 364

22490
206
AA899289

KIAA1049 protein
A

15761
345
AF062741

KIAA1348 protein, protein phosphatase 1G (formerly 2C), magnesium-dependent,
B





gamma isoform

25379
1156
NM_053713

Kruppel-like factor 1 (erythroid), Kruppel-like factor 2 (lung), Kruppel-like factor 4 (gut)
GENERAL, C

410
358
AI008974

low density lipoprotein receptor-related protein associated protein 1, low density
GENERAL, E





lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-





associated protein 1)

409
695
AI232268

low density lipoprotein receptor-related protein associated protein 1, low density
GENERAL, I





lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-





associated protein 1)

408
1169
NM_053961

low density lipoprotein receptor-related protein associated protein 1, low density
GENERAL





lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-





associated protein 1)

406
1259
Z11995

low density lipoprotein receptor-related protein associated protein 1, low density
GENERAL





lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-





associated protein 1)

407
1259
Z11995

low density lipoprotein receptor-related protein associated protein 1, low density
C





lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-





associated protein 1)

21653
753
AI237535

LPS-induced TNF-alpha factor
GENERAL, C, K

21654
1221
U53184

LPS-induced TNF-alpha factor
GENERAL, I, L

8317
149
AA892234

microsomal glutathione S-transferase 3
GENERAL

17923
178
AA892843

mitochondrial ribosomal protein L24
D

20866
236
AA926098

mitochondrial ribosomal protein L53
J

19152
768
AI639387

mitochondrial ribosomal protein S6
GENERAL, D

3925
75
AA851017

molybdenum cofactor synthesis 2
A, E

809
1207
U17035

monokine induced by gamma interferon, small inducible cytokine B subfamily (Cys-X-Cys
C





motif), member 13 (B-cell chemoattractant), small inducible cytokine B subfamily (Cys-X-





Cys), member 10, small inducible cytokine subfamily B (Cys-X-Cys), member 10, small





inducible cytokine subfamily B (Cys-X-Cys), member 11

17223
605
AI176140

MORF-related gene 15, RIKEN cDNA 1700060H10 gene, testis expressed gene 189
D

21672
132
AA891789

MORF-related gene X
C, D

1462
733
AI235585

Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched library,
GENERAL, E, G,





clone: 1810054L16:kidney-derived aspartic protease-like protein, full insert sequence,





cathepsin D, cathepsin D (lysosomal aspartyl protease)

1463
1241
X54467

Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched library,
GENERAL, G, K





clone: 1810054L16:kidney-derived aspartic protease-like protein, full insert sequence,





cathepsin D, cathepsin D (lysosomal aspartyl protease)

23810
402
AI012781

Mus musculus adult male brain cDNA, RIKEN full-length enriched library,
E





clone: 0710008P15:enhancer of zeste homolog 1 ( Drosophila ), full insert sequence,





enhancer of zeste homolog 2 ( Drosophila ), nuclear receptor binding SET domain protein 1

19824
995
NM_021750

Mus musculus adult male liver cDNA, RIKEN full-length enriched library,
G, K





clone: 1300015E02:deoxyribonuclease II alpha, full insert sequence, cysteine sulfinic acid





decarboxylase-related protein 2

23261
226
AA925145

Mus musculus adult male testis cDNA, RIKEN full-length enriched library,
GENERAL, I





clone: 4930572N12:betaine-homocysteine methyltransferase, full insert sequence, betaine





homocysteine methyltransferase, betaine-homocysteine methyltransferase 2

22781
111
AA874926

Mus musculus dual specificity phosphatase T-DSP10 mRNA, complete cds, RIKEN
F





cDNA 5930436K22 gene, protein phosphatase

22783
205
AA894207

Mus musculus dual specificity phosphatase T-DSP10 mRNA, complete cds, RIKEN
A, F





cDNA 5930436K22 gene, protein phosphatase

23093
217
AA924342

Mus musculus dual specificity phosphatase T-DSP10 mRNA, complete cds, RIKEN
G





cDNA 5930436K22 gene, protein phosphatase

15790
1135
NM_053341

Mus musculus mRNA for PDZ-domain protein Gipc3, complete cds, PDZ domain protein
E





GIPC2, expressed sequence AU021850, regulator of G-protein signaling 19 interacting





protein 1, regulator of G-protein signalling 19 interacting protein 1, semaF cytoplasmic





domain associated protein 2

15791
1135
NM_053341

Mus musculus mRNA for PDZ-domain protein Gipc3, complete cds, PDZ domain protein
C





GIPC2, expressed sequence AU021850, regulator of G-protein signaling 19 interacting





protein 1, regulator of G-protein signalling 19 interacting protein 1, semaF cytoplasmic





domain associated protein 2

24484
1128
NM_052806

Mus musculus nicotinic acetylcholine receptor beta4 subunit (Chmb4) mRNA, complete
H





cds, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal), cholinergic receptor,





nicotinic, beta polypeptide 4

19184
631
AI178025

Mus musculus testis expressed homeobox mRNA, complete cds, RIKEN cDNA
GENERAL, H, I





5430405H02 gene, RIKEN cDNA 5730599O09 gene, TG interacting factor, TGF(beta)-





induced transcription factor 2-like, TGFB-induced factor (TALE family homeobox), TGFB-





induced factor 2 (TALE family homeobox)

11653
62
AA848689

Mus musculus , Carbonic anhydrase-related protein 10, clone MGC: 27641
A, F





IMAGE: 4507552, mRNA, complete cds, carbonic anhydrase 11, carbonic anhydrase 5,





carbonic anhydrase 5a, mitochondrial, carbonic anhydrase 5b, mitochondrial, carbonic





anhydrase 7, carbonic anhydrase VA, mitochondrial, carbonic anhydrase VB,





mitochondrial

1962
995
NM_021750

Mus musculus , clone IMAGE: 3491119, mRNA, partial cds, Rattus norvegicus 3beta-
J





hydroxysteroid dehydrogenase/delta5-delta4 isomerase (3beta-HSD) mRNA, complete





cds, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1,





hydroxysteroid dehydrogenase-1, delta<5>-3-beta, hydroxysteroid dehydrogenase-2,





delta<5>-3-beta, hydroxysteroid dehydrogenase-3, delta<5>-3-beta, hydroxysteroid





dehydrogenase-6 delta<5>-3-beta

35
1162
NM_053840

Mus musculus , clone MGC: 12004 IMAGE: 3602314, mRNA, complete cds, RIKEN cDNA
C





9030405D14 gene, gamma-glutamyl transpeptidase, gamma-glutamyltransferase 1

699
1223
U55765

Mus musculus , clone MGC: 25863 IMAGE: 4196269, mRNA, complete cds, Mus
E





musculus , clone MGC: 37860 IMAGE: 5100400, mRNA, complete cds, serine (or cysteine)





proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10, serine





protease inhibitor 1-1

4312
333
AB010635

Mus musculus , clone MGC: 28542 IMAGE: 4194872, mRNA, complete cds, Mus
J





musculus , clone MGC: 31116 IMAGE: 4163362, mRNA, complete cds, carboxylesterase





1, carboxylesterase 1 (monocyte/macrophage serine esterase 1), carboxylesterase 2





(intestine, liver), carboxylesterase 3, carboxylesterase 3 (brain), carboxylesterase-related





protein, expressed sequence AI266984. neuroligin 1

15132
684
AI231180

Mus musculus , clone MGC: 28736 IMAGE: 4461170, mRNA, complete cds, R. norvegicus
G





mRNA for unknown protein (PIPPin), RIKEN cDNA 1200011K09 gene, calcium-regulated





heat-stable protein (24 kD), ortholog of rat pippin

11162
354
AI008183

Mus musculus , clone MGC: 38048 IMAGE: 5250967, mRNA, complete cds, RIKEN cDNA
C





4933435C21 gene, solute carrier family 29 (nucleoside transporters), member 1

21695
1191
NM_130411

Mus musculus , Similar to coronin, actin binding protein, 2A, clone IMAGE: 4984475,
G





mRNA, partial cds, coronin, actin binding protein 1A, coronin, actin binding protein, 1A

19058
342
AF054618

Mus musculus , Similar to cortactin isoform B, clone MGC: 18474 IMAGE: 3981559,
E





mRNA, complete cds, cortactin, ems1 sequence (mammary tumor and squamous cell





carcinoma-associated (p80/85 src substrate), hematopoietic cell specific Lyn substrate 1,





hematopoietic cell-specific Lyn substrate 1

3454
1155
NM_053662

Mus musculus , Similar to cyclin K, clone MGC: 28173 IMAGE: 3986609, mRNA, complete
J





cds, Paneth cell enhanced expression, RIKEN cDNA 1810009O10 gene, cyclin L, cyclin





T1, cyclin T2

20741
347
AF084186

Mus musculus , similar to src homology three (SH3) and cysteine rich domain, clone
A, J





MGC: 38869 IMAGE: 5361431, mRNA, complete cds, RIKEN cDNA 2610027H02 gene,





RIKEN cDNA 2610301F02 gene, alpha-spectrin 1, erythroid, nesprin-1, spectrin, alpha,





erythrocytic 1 (elliptocytosis 2), spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), src





homology three (SH3) and cysteine rich domain

14970
1059
NM_031127

Mus musculus , Similar to sulfite oxidase, clone MGC: 28458 IMAGE: 4160277, mRNA,
GENERAL, B, H, I, K





complete cds, RIKEN cDNA 1810044O22 gene, RIKEN cDNA 2810034J18 gene, sulfite





oxidase

16881
190
AA893185

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 (16 kD, SGDH)
J

18509
526
AI104528

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 (17 kD, B17)
A

21302
404
AI013297

NADH dehydrogenase (ubiquinone) Fe—S protein 4, NADH dehydrogenase (ubiquinone)
J





Fe—S protein 4 (18 kD) (NADH-coenzyme Q reductase)

23843
296
AA957410

NCK adaptor protein 2
D

14638
551
AI137049

Nijmegen breakage syndrome 1 (nibrin), nibrin
J

1508
1163
NM_053845

Nit protein 2, expressed sequence AI195023, nitrilase 1, ureidopropionase, beta
G

3874
419
AI029428

nuclear cap binding protein subunit 1, 80 kD
GENERAL, I

3875
727
AI235047

nuclear cap binding protein subunit 1, 80 kD
GENERAL, A

13111
553
AI137224

oxysterol binding protein 2
GENERAL

14332
775
AJ001044

p53-induced protein PIGPC1, tumor-associated calcium signal transducer 1
D

20457
986
NM_020073

parathyroid hormone receptor, parathyroid hormone receptor 1, parathyroid hormone
GENERAL, B, K, L





receptor 2

20458
986
NM_020073

parathyroid hormone receptor, parathyroid hormone receptor 1, parathyroid hormone
GENERAL, I, K, L





receptor 2

4290
1141
NM_053487

peroxisomal biogenesis factor 11A, peroxisomal biogenesis factor 11B, peroxisomal
L





biogenesis factor 11a, peroxisomal biogenesis factor 11b

7270
406
AI013564

PEST-containing nuclear protein
D

21976
266
AA946011

phosphatidylinositol-4-phosphate 5-kinase, type II, beta, phosphatidylinositol-4-phosphate
B





5-kinase, type II, gamma

5295
240
AA926247

potassium channel, subfamily K, member 1, potassium channel, subfamily K, member 1
GENERAL, L





(TWIK-1), potassium channel, subfamily K, member 7, potassium channel, subfamily K,





member 8

19665
993
NM_021688

potassium channel, subfamily K, member 1, potassium channel, subfamily K, member 1
D, L





(TWIK-1), potassium channel, subfamily K, member 7, potassium channel, subfamily K,





member 8

19469
146
AA892112

proline dehydrogenase, proline dehydrogenase (oxidase) 1
GENERAL, D

1422
1066
NM_031324

prolyl endopeptidase
GENERAL, B, G, L

25198
996
NM_021754

PRP31 pre-mRNA processing factor 31 homolog (yeast), RIKEN cDNA 1500019O16
GENERAL, I, K





gene, nucleolar protein 5, nucleolar protein 5A (56 kD with KKE/D repeat), nucleolar





protein NOP5/NOP58

20035
996
NM_021754

PRP31 pre-mRNA processing factor 31 homolog (yeast), RIKEN cDNA 1500019O16
GENERAL, H





gene, nucleolar protein 5, nucleolar protein 5A (56 kD with KKE/D repeat), nucleolar





protein NOP5/NOP58

19822
643
AI179599

RAB7, member RAS oncogene family-like 1, RAB9, member RAS oncogene family,
A





RAB9A, member RAS oncogene family, RAB9B, member RAS oncogene family, RIKEN





cDNA 2810011A17 gene

18300
878
NM_013030

Rattus norvegicus mRNA for Na+/Pi-cotransporter type IIc, complete cds, Solute carrier
GENERAL, H, I, L





family 17 (sodium/hydrogen exchanger), member 2, expressed sequence AI649385,





solute carrier family 34 (sodium phosphate), member 1

1515
1053
NM_031095

renin binding protein
J

10789
1039
NM_024399

RIKEN cDNA 0610006H10 gene, aspartoacylase (aminoacylase 2, Canavan disease),
GENERAL





aspartoacylase (aminoacylase) 2, similar to RIKEN cDNA 0610006H10 gene

18452
913
NM_017074

RIKEN cDNA 0610010I13 gene, cystathionase (cystathionine gamma-lyase), expressed
GENERAL





sequence AI098105

18453
913
NM_017074

RIKEN cDNA 0610010I13 gene, cystathionase (cystathionine gamma-lyase), expressed
G





sequence AI098105

23321
176
AA892821

RIKEN cDNA 0610025K21 gene, aflatoxin B1 aldehyde reductase, aldo-keto reductase
GENERAL





family 7, member A2 (aflatoxin aldehyde reductase)

20864
901
NM_013215

RIKEN cDNA 0610025K21 gene, aldo-keto reductase family 7, member A2 (aflatoxin
B, J





aldehyde reductase)

18001
79
AA858573

RIKEN cDNA 0610038O04 gene, secreted phosphoprotein 2, 24 kD
GENERAL

17999
1211
U19485

RIKEN cDNA 0610038O04 gene, secreted phosphoprotein 2, 24 kD
GENERAL

18000
1211
U19485

RIKEN cDNA 0610038O04 gene, secreted phosphoprotein 2, 24 kD
I

14763
256
AA944481

RIKEN cDNA 1110007F23 gene, angiopoietin 2, angiopoietin-like 3, angiopoietin-like 4,
L





ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), ficolin





(collagen/fibrinogen domain containing) 1, ficolin B

1549
1009
NM_022508

RIKEN cDNA 1110019K23 gene, methylene tetrahydrofolate dehydrogenase (NAD+
G





dependent), methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate





dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase,





methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate





cyclohydrolase, formyltetrahydrofolate synthase, methylenetetrahydrofolate





dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase,





formyltetrahydrofolate synthetase

15800
1159
NM_053810

RIKEN cDNA 1300018G05 gene, synaptosomal-associated protein, 29 kD
A

25467
818
M93297

RIKEN cDNA 1300019H02 gene, RIKEN cDNA 2900006B13 gene, omithine
G





aminotransferase, omithine aminotransferase (gyrate atrophy)

21253
530
AI105110

RIKEN cDNA 1500010M16 gene, translation factor sui1 homolog
F

12921
546
AI112636

RIKEN cDNA 1700124F02 gene, uridine phosphorylase
GENERAL, B, L

3878
193
AA893230

RIKEN cDNA 2310068O22 gene, calmodulin 1, calmodulin 1 (phosphorylase kinase,
GENERAL





delta), calmodulin 2, calmodulin 2 (phosphorylase kinase, delta), calmodulin 3, calmodulin





like 3, centrin 1, centrin, EF-hand protein, 1, expressed sequence AI327027, expressed





sequence AL024000, troponin C, fast skeletal

24233
308
AA964756

RIKEN cDNA 2310068O22 gene, calmodulin 1, calmodulin 2, calmodulin-like 3, centrin 1,
F





centrin, EF-hand protein, 1, centrin, EF-hand protein, 2, expressed sequence AI327027,





expressed sequence AL024000, troponin C, fast skeletal, troponin C2, fast

16168
194
AA893280

RIKEN cDNA 2310076L09 gene, adipose differentiation related protein, adipose
GENERAL, J





differentiation-related protein

16169
430
AI030932

RIKEN cDNA 2310076L09 gene, adipose differentiation related protein, adipose
J





differentiation-related protein

3172
317
AA997406

RIKEN cDNA 2410072D24 gene, proteasome (prosome, macropain) subunit, alpha type
B





7, proteasome (prosome, macropain) subunit, alpha type, 7

13157
558
AI138020

RIKEN cDNA 2610016A03 gene, polyamine N-acetyltransferase
D

7700
534
AI105383

RIKEN cDNA 2610037M15 gene, sphingosine kinase 1, sphingosine kinase 2
GENERAL, D

2098
20
AA799995

RIKEN cDNA 3100001N19 gene, ribosomal protein L14
C

23166
100
AA859954

RIKEN cDNA 4930579A11 gene, likely ortholog of rat vacuole membrane protein 1
GENERAL, C, L

16082
109
AA874887

RIKEN cDNA C030018L16 gene, SMC (segregation of mitotic chromosomes 1)-like 1
E





(yeast), SMC (structural maintenace of chromosomes 1)-like 2 ( S. cerevisiae ), SMC





(structural maintenance of chromosomes 1)-like 1 ( S. cerevisiae ), SMC1 structural





maintenance of chromosomes 1-like 1 (yeast), SMC4 structural maintenance of





chromosomes 4-like 1 (yeast)

16552
1169
NM_053961

RIKEN cDNA C030022K24 gene, chromosome 12 open reading frame 8, endoplasmic
L





reticulum protein 29

17088
142
AA891998

sequestosome 1
B, L

1439
1224
U57391

SH2-B PH domain containing signaling mediator 1, SH2-B homolog, adaptor protein with
H





pleckstrin homology and src, adaptor protein with pleckstrin homology and src homology





2 domains, src homology 2 domain-containing transforming protein C3

7888
715
AI233583

similar to arginyl-tRNA synthetase
GENERAL

23538
506
AI102727

solute carrier family 20 (phosphate transporter), member 1, solute carrier family 20
GENERAL





(phosphate transporter), member 2, solute carrier family 20, member 1, solute carrier





family 20, member 2

17468
165
AA892545

solute carrier family 22 (organic cation transporter), member 1-like
D

23509
383
AI010962

sorting nexin 3
A

11692
758
AI638982

sulfotransferase family, cytosolic, 1C, member 1
GENERAL

15004
729
AI235224

tissue inhibitor of metalloproteinase, tissue inhibitor of metalloproteinase 1 (erythroid
GENERAL, G, K





potentiating activity, collagenase inhibitor)

15002
1160
NM_053819

tissue inhibitor of metalloproteinase, tissue inhibitor of metalloproteinase 1 (erythroid
GENERAL, E, G, K





potentiating activity, collagenase inhibitor)

15003
1160
NM_053819

tissue inhibitor of metalloproteinase, tissue inhibitor of metalloproteinase 1 (erythroid
G, K





potentiating activity, collagenase inhibitor)

16039
1107
NM_031811

transaldolase 1
H

7505
1013
NM_022534

transcobalamin 2, transcobalamin II; macrocytic anemia
A

2125
502
AI102519

TYRO protein tyrosine kinase binding protein
G

16469
160
AA892462

ubiquinol-cytochrome c reductase (6.4 kD) subunit
A, C

16468
238
AA926137

ubiquinol-cytochrome c reductase (6.4 kD) subunit
A

18597
1067
NM_031325

UDP-glucose dehydrogenase
B, H

15576
148
AA892132

uncharacterized hematopoietic stem/progenitor cells protein MDS032
J

12331
1180
NM_057155

X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, membrane-bound
GENERAL, H





aminopeptidase P

12332
1180
NM_057155

X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, membrane-bound
GENERAL, G





aminopeptidase P

15008
340
AF038591

X-prolyl aminopeptidase (aminopeptidase P)-like, cytosolic aminopeptidase P
E















































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































TABLE 4





CODE KEY



Atty. Docket No. GENE-077/26US

Doc. No. 44941






GLGC Model
Model Code





General Nephrotoxicity
GENERAL


Chloroform
A


Diclofenac
B


Menadione
C


SodiumChromate
D


SodiumOxalate
E


Thioacetamide
F


Vancomycin
G


S2
H


Tubular Toxicity
I


Glomerular Injury
J


Tubular Obstruction
K


NSAIDS
L













































TABLE 5





GENERAL



Atty. Docket No. GENE-077/26US

Doc. No. 44941










Tox
Tox
Non-Tox
Non-Tox

GLGC

Group
Group
Group
Group

Identifier
LDA Score
Mean
SD
Mean
SD










3050
76.59
151.97
82.62
77.07
24.98

10789
71.31
226.28
98.93
319.54
77.45

14020
70.44
212.80
56.70
266.01
46.38

15955
73.57
515.14
191.35
728.18
122.31

24321
70.99
515.86
195.77
686.86
131.04

5601
74.82
640.28
294.69
934.56
178.65

4440
73.28
210.00
74.37
306.59
75.86

7285
72.30
183.98
45.26
227.37
39.94

12467
70.48
91.52
43.59
57.64
16.70

19998
70.32
192.15
78.72
267.63
67.09

3823
75.50
654.04
216.61
458.26
76.00

11967
70.95
1213.17
570.43
1709.91
412.19

13954
71.06
948.19
350.16
1298.60
301.79

17907
71.03
1012.87
306.06
1257.12
200.00

14095
70.92
281.28
79.38
369.45
63.47

6046
77.32
132.00
60.76
209.20
53.92

7888
71.84
318.41
78.58
247.97
40.89

6416
72.17
221.69
181.98
105.92
33.73

14677
73.22
105.84
49.33
62.34
18.47

3875
75.61
354.67
119.89
510.04
111.81

15004
71.20
315.68
341.04
126.60
39.41

11164
73.11
349.24
142.19
507.35
120.35

6336
70.98
336.24
89.69
418.43
89.90

3091
76.72
545.67
168.85
749.73
128.16

14867
70.80
101.12
62.31
165.12
71.18

15051
72.81
870.06
414.32
531.84
140.63

16859
71.33
166.91
73.19
112.81
33.48

24388
72.16
256.14
119.20
163.06
35.67

18303
70.44
281.64
239.24
513.56
243.07

3467
73.26
477.56
179.67
670.32
151.77

7279
70.58
177.33
131.04
191.37
58.86

5867
70.42
195.07
60.67
148.14
26.48

17361
77.49
81.56
49.55
151.85
49.33

21025
74.37
313.31
107.42
441.97
94.86

16314
77.26
103.96
76.71
33.61
21.85

1698
70.92
172.23
191.95
50.55
32.52

5297
67.89
282.49
103.56
368.51
102.45

8317
68.06
1149.89
388.88
1428.19
346.12

11454
70.33
328.59
156.12
216.73
53.33

11455
70.50
162.65
95.78
94.80
26.70

1850
67.86
62.21
93.09
24.45
96.13

15295
67.57
171.07
70.81
126.38
31.75

17734
71.76
206.37
202.42
95.30
30.54

20817
68.72
1865.76
1135.85
1150.17
447.11

21061
68.32
67.94
30.57
46.71
18.28

22352
69.21
240.63
198.59
129.55
52.38

22662
69.52
107.46
29.01
136.36
29.33

23837
68.09
121.06
52.18
85.23
27.33

20801
71.85
199.99
73.50
140.35
32.13

353
70.73
272.05
161.59
149.39
40.00

354
71.60
342.25
192.43
190.95
42.15

7101
73.48
1028.63
1448.92
269.03
75.33

17541
67.78
1031.81
707.66
671.17
173.64

1399
70.32
291.48
158.06
180.41
40.15

1454
69.83
155.56
72.94
98.16
40.12

15185
68.29
234.32
137.00
142.70
43.80

23445
68.77
516.36
187.24
686.21
139.36

25070
70.39
353.20
90.91
442.88
89.02

20818
67.77
1218.48
808.49
683.44
312.98

20161
74.51
72.01
53.68
25.32
16.61

17157
70.27
66.75
35.98
40.40
14.13

20457
74.51
307.25
108.92
417.65
84.52

18300
75.29
313.22
163.49
527.19
147.37

1727
73.95
105.41
122.47
22.30
20.76

11483
73.32
116.30
97.07
45.20
13.89

23868
75.06
476.59
578.57
104.39
73.16

21145
68.42
166.45
59.78
210.98
64.34

22602
68.23
241.70
126.48
348.96
102.98

16649
67.98
147.87
84.06
97.60
32.65

17324
69.51
312.59
107.12
383.77
72.30

16006
68.36
71.88
53.76
35.40
17.42

25198
71.55
41.84
21.30
24.47
10.29

744
69.51
282.84
77.81
353.13
70.01

5496
69.23
508.95
208.94
686.29
135.72

5497
69.71
618.39
241.87
823.93
151.32

10015
71.92
325.47
153.58
212.06
42.33

10016
71.00
301.53
145.98
190.35
43.04

2554
67.63
57.16
20.54
42.64
12.31

2555
78.32
138.95
71.04
72.75
17.34

3608
73.18
234.71
128.06
383.50
124.15

1214
68.38
128.30
68.13
158.55
45.71

18452
69.52
321.39
118.91
424.39
94.63

20493
69.93
391.49
143.65
510.95
105.19

28
78.46
337.76
190.36
572.67
145.84

3987
68.10
229.04
70.17
180.46
37.27

17159
72.54
1017.46
356.32
743.47
134.89

574
75.37
578.23
363.75
306.48
52.52

25379
69.82
91.37
33.44
67.37
15.00

24219
76.53
444.44
155.56
293.46
58.45

20458
75.73
275.50
100.52
389.11
82.95

8829
72.83
370.34
120.13
265.09
63.72

21882
72.04
626.54
164.71
793.68
153.08

1430
69.19
91.41
91.79
157.32
82.87

25453
72.92
169.54
55.07
219.24
42.22

7872
70.14
85.77
33.42
118.89
31.25

5837
69.05
707.52
227.34
877.59
176.16

5838
67.71
538.51
169.64
674.95
122.93

7196
73.11
293.56
170.45
155.35
40.04

8210
68.29
744.10
212.87
921.28
180.15

3244
69.31
95.07
31.63
119.82
24.28

1460
75.38
290.35
157.01
170.57
30.83

25567
70.13
673.51
317.82
438.95
133.11

3430
70.44
621.18
275.86
418.22
103.80

22196
68.49
63.02
25.82
44.77
14.72

16708
70.11
207.75
51.37
256.42
46.45

24234
69.97
302.51
219.14
168.07
50.65

2153
69.24
324.59
302.82
143.84
45.14

1546
67.70
196.17
73.15
253.35
55.86

14996
71.12
339.33
144.00
507.21
153.71

20449
68.80
100.49
132.92
33.15
21.87

18606
67.59
847.38
254.52
660.80
115.15

20848
75.49
739.86
245.09
506.98
87.27

19678
74.00
44.46
60.23
110.35
45.84

17175
67.70
829.25
224.80
660.02
115.42

25705
68.69
571.36
176.40
451.97
76.32

21657
67.75
540.36
166.22
426.24
80.59

25718
67.76
500.44
141.40
404.97
60.85

13646
68.61
999.55
297.34
776.97
122.96

16012
68.18
93.81
55.30
58.56
15.00

25747
71.58
77.46
61.57
34.94
16.33

12978
77.09
161.06
78.86
82.73
24.07

25777
70.16
731.13
475.10
385.64
125.24

406
69.98
313.92
96.72
398.37
80.51

10887
73.15
45.60
19.26
68.19
20.96

24431
75.66
140.50
186.74
42.64
13.20

24438
68.73
114.07
42.85
148.98
36.10

17269
68.45
556.66
223.69
748.94
194.32

24496
73.35
77.54
41.57
118.88
29.67

20414
68.68
85.25
29.18
114.52
31.67

291
68.98
188.63
56.91
232.01
38.29

24770
67.96
167.86
99.91
258.46
101.06

45
69.84
120.96
88.26
186.49
67.03

24568
72.93
100.99
45.78
166.37
65.68

17999
68.25
901.71
380.29
1228.53
405.22

15851
68.33
317.19
273.69
160.11
75.58

18011
68.45
55.33
47.59
21.92
18.16

556
69.38
55.50
17.48
75.28
24.04

770
67.51
701.61
282.78
933.20
236.57

794
73.03
150.00
59.20
220.62
54.40

811
73.48
192.98
69.93
265.15
46.49

812
77.52
110.30
37.74
159.20
31.00

24648
69.01
23.19
11.70
35.71
12.85

1246
75.48
51.06
35.74
88.19
29.97

21053
68.52
66.73
31.72
102.83
48.28

11692
69.79
1135.77
414.48
1546.52
408.08

15330
75.22
58.49
22.62
86.85
21.03

19152
69.04
209.49
82.42
150.47
38.00

19679
72.17
554.05
249.84
799.21
160.22

19943
69.50
284.30
126.39
383.93
104.87

20082
71.73
92.50
42.33
59.76
14.72

20056
75.15
244.80
87.52
328.98
56.50

14970
76.68
152.21
48.93
210.61
31.30

15110
75.65
524.74
161.30
744.40
164.54

17684
70.48
183.88
61.32
243.76
49.96

408
69.14
130.38
67.28
191.46
65.83

18564
71.21
177.18
50.69
222.90
43.22

15299
76.65
136.30
106.16
61.66
17.89

1798
70.19
258.62
95.82
346.73
96.89

825
67.73
33.82
15.83
49.46
17.83

17473
68.53
518.00
161.86
427.54
71.99

13151
76.24
1189.02
539.58
699.61
197.75

1409
71.37
356.35
100.26
457.09
90.41

17908
74.57
121.36
116.12
42.53
16.55

1501
72.34
109.79
98.72
39.88
21.66

15002
73.73
244.23
206.55
112.57
27.72

15190
67.62
3108.28
1723.86
1862.43
876.50

4235
72.16
511.71
134.64
389.70
70.88

20828
73.01
502.25
271.18
284.53
92.49

7197
69.38
282.33
150.96
170.15
54.40

15191
68.53
3290.47
1751.22
2180.50
805.93

14989
68.14
631.44
150.80
512.71
97.02

15642
71.14
552.69
175.75
408.68
83.66

24264
69.25
26.11
22.43
43.28
18.56

17196
72.16
105.36
26.39
132.08
22.43

15039
73.41
191.98
102.72
287.95
78.11

409
68.88
803.46
193.90
969.12
164.62

13392
70.20
239.32
71.29
181.66
37.09

1462
73.80
698.28
424.37
379.74
81.29

21653
72.94
312.54
114.31
222.64
40.98

1712
68.62
209.69
68.61
160.39
35.88

4451
67.65
238.86
88.60
300.33
63.65

16726
67.70
870.29
304.51
1099.44
185.70

17807
70.62
1025.46
284.12
795.89
128.79

17357
74.57
177.83
108.45
287.60
80.31

23651
79.97
1637.54
1189.42
542.91
191.30

6055
67.75
852.91
291.95
1087.75
221.20

17104
68.26
595.24
185.16
458.24
73.96

19040
77.34
341.45
225.23
150.68
34.34

20816
68.80
595.84
369.92
370.47
83.63

15111
74.61
829.53
273.33
1166.38
236.68

23872
71.41
128.39
182.32
24.92
23.80

16684
70.36
709.36
236.74
508.89
112.43

18301
68.57
62.34
33.80
100.81
42.71

18302
71.39
60.93
77.95
124.38
68.01

20780
68.40
441.75
191.55
567.49
192.61

19
69.63
426.88
118.63
336.43
62.64

12349
74.05
196.48
54.09
244.57
51.80

275
70.45
453.71
254.44
576.80
132.19

20481
71.33
164.23
44.85
208.90
36.60

20829
70.25
1242.42
483.51
851.32
199.41

20830
74.35
763.47
278.51
513.07
135.94

1581
70.90
84.40
27.90
62.31
13.19

21443
72.53
141.51
81.92
79.90
27.47

1478
70.03
270.27
105.77
371.66
79.44

20753
69.46
146.99
39.00
114.61
22.23

21654
80.33
549.42
209.67
339.69
55.84

20865
70.38
235.52
58.52
291.31
53.15

405
71.41
163.66
53.25
214.37
52.03

1463
70.30
1010.91
562.23
597.63
147.52

6641
76.29
306.07
88.62
420.70
68.82

20849
70.93
372.72
145.97
262.85
56.36

16204
67.81
1040.09
276.03
829.95
117.99

17401
74.89
1485.70
694.85
908.51
210.90

21239
76.72
181.72
94.61
89.35
26.32

1885
70.24
271.09
74.77
352.55
81.06

16775
70.92
829.81
416.75
1259.06
355.54

1993
69.60
43.10
30.86
20.51
10.49

11849
69.60
948.18
279.84
737.49
123.97

755
68.38
34.87
29.79
64.08
34.39

4198
69.32
622.34
199.77
799.21
160.47

4199
70.34
447.79
168.99
592.87
144.27

16147
71.31
133.27
41.17
174.38
34.99

1141
71.70
310.45
97.82
226.16
48.17

15300
76.22
266.45
233.70
96.88
38.59

21147
75.23
286.27
82.62
378.80
67.04

15986
74.10
229.66
101.29
339.59
70.49

1422
74.28
203.51
89.60
319.04
84.84

15032
82.28
177.33
70.87
283.54
59.41

17393
70.75
204.12
109.17
121.38
33.64

17394
67.82
452.07
169.87
324.74
84.03

22321
77.79
179.86
123.24
75.47
26.58

4589
68.43
1175.41
346.46
1472.99
302.81

4327
71.73
124.90
64.17
73.51
19.33

21683
77.71
55.09
33.27
21.13
9.74

16520
70.54
132.86
84.97
72.66
44.25

18070
68.56
29.37
22.00
48.21
19.39

7489
78.41
39.97
22.84
80.91
28.10

1081
71.67
413.82
133.92
554.09
106.66

1510
72.14
644.69
250.30
882.92
187.47

7784
72.19
562.83
162.41
718.79
107.93

16476
69.47
661.97
207.06
807.34
148.25

23961
70.55
666.12
193.40
805.83
112.84

1529
78.52
215.94
69.39
311.30
57.34

10464
72.10
93.88
31.76
126.65
27.53

16982
82.32
483.69
552.30
49.88
32.90

18001
68.00
322.92
154.38
447.93
164.83

4178
69.85
527.87
134.53
640.23
119.95

19067
70.28
126.08
48.73
169.73
43.06

14138
68.34
60.32
26.71
75.29
17.84

14184
69.13
138.85
74.22
90.86
35.51

14185
72.71
286.60
150.72
168.45
57.75

23166
78.56
206.85
101.43
108.11
29.94

13974
67.81
486.20
343.78
277.98
70.48

4462
70.66
730.63
304.66
995.43
245.77

18741
68.46
22.46
9.47
31.42
12.25

16312
78.77
101.86
64.40
38.36
14.62

7936
75.61
108.44
31.04
144.70
27.85

15618
74.29
115.86
40.32
80.50
17.75

4360
71.67
269.80
91.90
345.45
58.55

24235
70.28
713.05
392.66
431.13
115.32

17420
70.15
61.25
32.18
94.13
32.93

17256
71.81
324.85
154.43
449.98
98.33

18269
70.99
637.39
170.20
810.10
163.94

9905
75.17
584.58
181.18
780.68
116.13

4463
74.77
101.60
62.28
161.67
53.31

17438
70.47
26.74
45.54
57.63
34.17

1159
70.78
806.92
265.61
1032.09
192.03

4473
71.43
131.05
57.90
181.27
41.72

23047
67.77
56.55
20.02
70.52
16.28

19469
68.42
301.34
113.03
382.87
90.35

18190
68.25
182.25
61.26
229.51
48.59

17161
76.03
1821.71
615.92
1215.71
234.86

19768
70.65
963.11
248.77
752.70
130.89

17682
77.92
543.63
230.34
801.63
133.44

23194
69.65
62.70
24.82
41.17
22.22

13609
74.00
176.81
58.87
251.92
56.78

13610
76.70
274.96
90.97
381.83
61.63

8599
70.30
289.71
121.75
408.81
103.34

12276
69.15
146.83
72.19
197.32
55.12

18906
74.86
170.78
84.29
280.26
81.30

19085
70.14
94.40
39.41
61.51
14.57

19086
69.77
146.30
67.62
91.90
25.41

23783
68.29
395.54
88.23
467.98
73.38

22537
69.21
218.54
146.77
320.54
127.57

22538
67.97
268.39
96.52
356.51
83.52

22539
69.48
36.74
37.02
67.51
37.70

4529
69.23
67.85
27.85
90.38
24.21

23321
67.96
543.48
158.95
669.18
121.28

9053
76.00
188.41
54.90
248.83
39.54

13332
71.48
348.32
115.94
459.97
88.50

21305
70.70
335.54
107.08
461.13
122.43

17447
69.72
757.11
315.00
1014.03
248.79

17744
67.69
46.15
26.53
64.03
23.43

3878
70.74
403.23
111.47
513.41
109.35

16168
77.12
630.28
458.34
308.50
64.72

9082
68.21
53.73
28.47
38.09
10.56

3465
69.60
210.03
70.49
271.47
62.45

12031
67.78
168.78
59.30
130.32
25.69

18396
67.63
90.02
44.80
61.70
16.44

15302
68.05
20.31
8.69
27.82
10.24

23063
69.28
328.27
83.61
404.56
68.57

18361
67.66
621.87
267.20
448.88
121.61

14309
68.46
112.88
71.13
191.14
83.99

17494
68.74
185.71
45.49
223.03
37.75

18360
74.08
154.48
47.05
214.39
51.15

23202
72.92
121.82
37.42
164.36
35.74

23203
73.16
136.45
40.61
175.94
38.17

17325
76.58
189.74
208.06
31.06
24.22

13930
69.50
214.91
153.33
106.24
42.57

7543
70.50
178.55
78.57
269.04
91.31

22820
70.89
288.12
111.45
200.74
47.58

21125
71.35
116.79
56.18
159.82
40.70

17339
71.93
1792.99
669.14
2389.41
537.66

6635
70.12
193.74
78.12
263.66
72.24

21462
72.14
306.54
72.05
242.55
45.95

13349
72.86
172.75
55.73
123.93
27.78

24762
70.27
718.38
276.15
983.32
297.96

4661
70.12
388.81
126.78
288.37
54.81

9114
70.18
693.86
204.93
879.83
192.79

3822
73.37
1222.47
463.13
866.86
181.13

6039
71.15
398.06
140.85
292.56
43.87

21318
71.20
71.29
31.21
42.85
22.49

22681
78.67
469.72
361.56
167.25
55.58

6711
70.23
67.65
24.44
47.11
22.07

11974
70.51
172.05
92.75
244.79
74.37

22554
73.07
415.02
141.56
556.65
106.86

22612
75.13
343.73
116.51
484.30
98.81

22656
71.02
175.60
69.45
113.00
41.69

5565
70.16
296.76
131.21
413.36
102.23

18337
73.92
1205.41
398.90
1647.91
276.54

12331
71.08
472.78
167.06
617.17
120.69

12332
73.05
411.16
193.59
580.89
134.53

17499
70.54
50.18
30.54
22.00
22.13

3959
73.37
453.59
139.95
330.92
74.22

17477
72.97
152.23
61.42
103.95
20.62

4933
70.18
388.41
424.08
93.57
104.19

4944
74.65
188.84
90.79
105.86
33.59

23195
72.30
232.92
106.75
322.66
70.57

21458
72.29
333.72
163.53
208.78
68.34

14790
70.53
109.41
74.62
185.30
76.26

23261
74.33
1167.64
374.52
1601.58
272.59

18271
71.71
622.18
201.29
765.39
134.28

23978
73.34
86.93
32.19
116.83
26.50

13411
73.35
525.65
243.99
878.97
298.41

5295
70.27
300.37
122.64
200.38
56.99

22928
70.99
162.55
62.71
235.92
78.67

9452
70.35
245.76
292.62
114.97
32.36

23512
70.99
828.99
249.33
1077.38
203.72

22596
71.68
80.40
26.07
58.43
14.91

498
71.09
683.30
214.01
507.78
92.93

5990
70.86
366.35
68.11
308.36
51.82

23957
72.26
111.14
62.08
56.84
26.48

2702
71.60
366.96
146.76
258.70
49.00

2195
73.27
58.13
36.42
94.82
34.86

12561
73.13
102.28
52.57
159.13
45.42

2905
75.28
347.69
151.38
208.05
61.26

20694
73.26
743.85
251.48
959.05
180.74

3079
70.80
63.05
43.41
28.63
23.27

20035
73.52
306.77
177.36
157.60
53.17

6804
74.11
789.99
408.84
1302.23
346.25

3121
74.54
959.69
406.12
1369.21
250.58

22599
70.26
66.34
31.77
41.25
18.37

410
71.29
870.97
244.82
1083.44
197.61

21632
73.03
81.28
68.17
22.00
38.30

6382
71.38
168.36
54.67
117.22
30.59

15089
74.51
251.33
99.68
160.38
49.68

21105
70.12
249.54
66.26
312.18
54.81

12716
72.49
131.67
35.67
169.49
38.21

2912
72.39
1931.74
615.06
2564.08
522.30

6916
70.52
317.82
111.03
408.61
85.19

6927
70.39
264.79
87.91
348.90
78.76

17524
72.11
874.88
306.13
1156.44
234.27

3941
73.09
308.74
77.68
230.07
48.84

17550
72.46
986.16
374.79
1326.29
307.30

3995
75.44
463.57
147.80
633.82
110.34

6518
70.44
144.08
37.09
112.71
24.88

21796
70.33
888.40
360.47
657.75
113.15

23946
72.63
163.74
60.23
222.35
52.10

13633
71.57
490.86
292.91
281.77
78.22

2250
70.10
1118.06
305.47
1406.39
242.10

24200
75.63
597.89
203.15
387.86
82.10

7127
72.10
189.63
95.07
284.50
81.78

2242
78.44
1562.27
687.27
2311.30
401.81

20086
70.93
176.26
100.98
94.57
56.93

22592
74.45
441.33
302.53
185.74
92.86

15928
77.50
230.62
81.86
144.79
33.22

21391
75.21
385.81
231.51
186.38
64.93

7299
74.79
340.48
256.92
144.54
52.30

12812
71.13
71.16
36.21
103.45
31.82

3874
77.99
655.53
183.38
905.21
155.11

7537
71.69
182.30
58.80
237.28
52.88

2370
71.01
915.70
221.20
1099.41
156.58

7903
70.99
350.55
194.24
521.87
172.15

10818
74.69
290.08
197.30
507.06
156.48

2348
72.14
327.63
189.49
501.70
190.96

5329
70.75
33.31
19.25
51.50
17.82

5461
80.13
363.25
214.86
167.06
45.38

19235
70.79
763.49
289.13
1038.84
281.39

5711
72.45
273.46
99.05
392.06
106.55

5474
72.45
535.29
201.95
756.74
194.06

5855
72.52
48.55
32.00
74.58
25.26

7540
73.88
252.91
154.86
138.96
33.26

8143
74.69
104.77
84.14
29.09
30.03

4789
72.94
59.69
25.79
36.25
16.93

8188
72.32
307.46
113.44
412.60
118.99

8721
76.93
122.24
61.91
198.85
58.96

9067
70.10
803.78
204.39
624.95
138.76

14424
74.93
239.44
296.66
40.59
37.53

19031
73.02
115.05
95.44
48.91
21.83

18792
71.15
105.56
35.07
140.76
34.60

9583
83.08
136.55
110.28
37.67
13.20

22929
76.66
487.92
270.63
875.04
272.83

22930
71.79
198.01
107.43
333.60
130.90

9673
72.89
41.63
23.96
67.92
25.83

9699
71.31
40.80
21.59
56.86
17.18

9781
70.77
92.59
36.11
127.64
32.76

20003
71.55
27.27
18.64
51.09
22.28

21885
70.82
142.81
40.76
189.08
42.70

9468
70.74
42.87
35.25
68.53
31.39

4479
73.91
235.81
118.85
131.97
56.66

9017
72.38
76.73
33.17
116.29
36.85

3713
71.70
870.09
222.47
1118.08
183.65

12921
74.78
160.55
75.66
89.61
28.74

13111
70.79
174.86
60.32
227.47
55.78

6638
75.69
69.36
25.20
99.44
21.50

14458
75.02
66.07
38.46
29.15
17.52

3610
77.34
786.52
383.16
1195.76
266.77

8339
73.49
292.74
124.63
423.11
88.77

5923
70.80
483.78
173.48
620.25
121.74

6796
71.31
237.51
61.53
182.40
44.67

22885
73.32
1845.03
706.08
1184.43
338.85

7128
73.03
239.14
69.19
314.35
55.04

22101
73.01
95.07
89.98
187.48
72.69

24237
74.97
89.34
56.62
42.92
17.41

11618
78.26
253.39
122.31
409.80
86.37

12979
80.37
643.96
322.54
306.53
85.14

6321
71.43
574.05
185.59
430.15
101.43

23538
74.66
187.01
128.86
88.48
33.57

16756
76.04
221.62
72.76
160.63
27.83

12798
71.21
127.92
41.67
161.96
30.85

5199
71.59
426.68
194.60
588.24
150.06

7700
70.23
122.86
82.18
72.08
16.69

13343
73.07
157.21
46.99
208.91
43.13

17771
72.79
987.24
409.54
656.09
156.81

3916
72.16
521.25
191.64
693.18
117.69

14929
76.37
1275.17
801.09
653.70
132.62

10130
71.36
174.06
65.67
230.52
47.39

22626
72.89
183.92
157.82
66.65
23.30

4291
77.82
182.86
89.68
304.13
72.33

4330
74.56
347.34
137.46
482.98
108.28

19723
76.28
128.30
90.41
60.09
19.40

10087
71.09
1154.32
346.71
1463.96
251.64

11708
70.94
386.80
118.03
291.40
61.62

22747
70.84
74.15
30.31
98.19
26.54

21024
70.13
455.62
93.78
553.76
96.13

15382
77.33
389.13
422.35
77.25
48.54

7690
70.79
257.59
97.89
171.85
74.75

4952
73.35
155.59
74.76
95.46
25.89

15663
73.12
250.33
89.70
172.23
33.35

10985
74.58
800.41
240.23
1100.95
203.66

24236
70.36
98.11
31.97
73.04
15.29

23299
74.52
468.81
165.84
330.31
69.58

15146
70.08
203.62
143.51
112.76
37.18

5863
74.20
106.06
33.34
146.26
29.69

15964
81.61
743.87
299.36
1181.36
213.16

14425
79.32
289.30
105.74
184.96
40.75

14484
72.73
334.28
89.84
437.97
96.59

19184
80.30
184.51
138.40
57.13
21.22

6059
72.36
154.20
39.08
195.04
41.70

22197
75.26
157.37
70.51
101.32
27.04

8477
71.07
659.05
204.66
463.62
103.03

13611
74.84
171.03
92.33
268.13
69.59

13634
72.92
1089.91
505.62
708.27
127.16

15042
71.38
113.78
77.47
57.28
27.29

3049
71.78
291.79
154.63
166.94
53.28

22569
78.32
433.31
165.33
660.29
135.05

5481
71.53
91.61
65.17
28.15
47.24

6765
70.92
585.04
187.80
763.40
148.50

6487
73.18
87.46
24.67
113.17
25.19

15879
73.89
284.57
70.17
362.84
59.91

13727
73.69
67.87
42.12
119.18
37.60

13176
70.47
46.42
20.28
65.32
19.51

22328
70.21
317.09
111.22
404.07
93.92

12587
70.38
172.84
49.41
225.04
48.37

12961
73.90
137.35
37.57
177.07
32.16

18529
72.64
279.81
134.55
172.94
39.31

13618
72.50
131.45
42.44
95.50
21.06











































































































































































































































































































































































































































































































































TABLE 5A





CHLOROFORM



Atty. Docket No. GENE-077/26US

Doc. No. 44941











Tox



GLGC
LDA
Tox Group
Group
Non-Tox Group
Non-Tox

Identifier
Score
Mean
SD
Mean
Group SD










17824
85.62
205.14
27.09
142.57
42.17

10378
84.82
69.21
33.23
143.74
101.86

1653
85.35
686.13
93.92
993.47
242.55

3875
88.29
252.35
75.16
478.18
126.13

15836
86.00
121.07
16.96
214.57
101.58

3091
95.09
421.64
58.81
713.53
158.43

22855
85.05
373.13
49.91
519.30
117.46

17361
90.70
50.93
20.08
137.86
55.93

21025
92.15
233.83
71.17
418.06
106.83

23115
86.26
278.57
65.22
503.85
159.60

6343
82.92
46.79
4.81
34.28
11.62

11953
88.88
1079.47
146.45
1693.94
588.62

18509
83.95
311.54
43.78
430.03
88.77

20832
83.65
534.47
85.79
785.26
199.66

20833
82.32
1010.33
178.76
1449.79
326.39

21060
84.30
133.69
25.56
83.14
27.48

21061
83.52
86.99
17.50
50.51
22.34

15701
83.20
63.42
22.84
30.93
12.46

1143
82.38
131.83
21.57
92.25
32.27

16468
84.29
831.97
118.43
1136.11
219.87

17541
84.35
1464.81
514.58
725.03
344.90

3015
82.18
2837.91
186.68
2819.00
1012.99

20896
83.09
106.66
65.89
141.12
40.19

1570
85.17
98.50
59.57
39.00
13.49

2632
82.26
190.41
17.08
153.91
30.61

25168
83.29
32.68
2.87
23.16
9.80

15800
83.74
56.84
10.37
34.45
19.58

11843
83.88
61.43
4.65
52.11
10.69

20741
84.26
236.26
31.17
175.32
43.96

8829
87.88
505.66
151.99
282.86
84.70

21977
87.24
38.53
11.16
77.01
45.15

1460
81.41
281.25
87.21
192.24
83.91

24234
84.86
408.25
208.57
188.66
107.50

25643
88.48
187.37
74.36
110.76
25.22

23282
87.61
425.15
71.15
283.98
52.36

13646
82.98
1169.38
295.87
817.10
184.73

25777
84.83
1173.74
710.54
439.45
241.72

24437
82.76
56.38
5.77
61.94
29.69

1929
81.33
536.97
208.01
870.13
215.86

6127
83.24
41.36
8.04
64.30
27.81

20000
84.67
93.69
19.60
127.60
71.39

25862
82.39
38.61
8.30
23.01
10.20

25921
81.56
47.30
10.74
28.36
16.07

19679
83.24
440.67
183.93
755.52
202.10

825
82.62
22.20
8.99
46.45
18.16

1409
85.68
298.20
49.00
438.84
99.15

17516
85.33
500.55
239.88
547.02
127.42

15072
81.24
42.04
6.55
31.15
15.09

1949
83.61
57.75
7.72
90.12
37.12

1581
84.77
87.66
15.15
66.76
21.00

20725
88.97
621.86
57.64
801.80
141.09

21562
85.05
265.87
68.99
468.38
147.67

6641
84.21
233.86
84.82
396.94
88.30

1877
82.89
444.75
101.68
652.86
170.37

15032
87.42
175.94
47.04
265.22
74.56

19110
83.92
84.32
32.08
204.53
96.17

1509
81.62
431.65
81.24
550.73
118.16

20708
82.38
80.85
9.57
61.19
17.28

2439
86.44
102.63
17.35
147.69
27.96

16948
82.71
145.85
69.01
317.13
132.79

4178
86.29
444.39
54.78
619.34
136.02

20582
84.74
347.72
63.49
487.44
95.49

23033
87.21
431.39
57.07
579.07
117.99

19377
85.21
155.74
30.08
109.47
24.61

19144
82.32
36.63
8.07
25.15
10.80

4462
93.09
414.41
198.64
953.78
313.55

7936
83.74
93.98
18.72
137.68
31.48

1644
82.23
418.83
62.93
560.68
126.32

9905
81.30
538.90
116.34
744.96
153.52

4463
88.62
43.16
34.48
150.98
58.66

4473
86.50
95.76
32.22
172.47
49.25

16469
88.06
991.10
103.75
1321.05
271.57

13610
92.33
226.14
59.71
365.06
107.29

22537
84.18
145.19
78.83
301.55
137.94

7505
81.98
274.29
43.54
384.55
118.76

22783
83.67
473.86
73.76
347.89
212.99

11653
87.24
306.58
112.65
560.40
195.77

12129
84.85
245.65
111.61
646.79
334.57

3925
86.50
275.69
80.34
461.73
112.55

22490
86.42
811.57
139.35
602.93
96.00

4933
84.98
743.88
516.81
142.53
232.49

23718
84.42
65.41
10.03
97.59
40.96

2912
90.89
1436.37
179.76
2437.60
603.29

17524
86.71
799.10
105.47
1115.60
282.08

23509
89.88
1570.55
137.71
2086.99
379.49

14267
86.42
1171.51
258.92
1706.75
393.91

9116
86.14
269.31
52.99
392.85
75.60

3961
91.61
74.40
10.55
49.45
14.81

7216
86.71
123.29
34.23
234.44
71.10

7299
85.42
334.53
109.96
181.79
143.50

7634
84.86
538.91
181.95
645.21
126.88

14856
86.45
330.60
53.33
438.34
100.70

8721
85.83
73.87
43.04
183.86
66.21

26183
84.58
64.68
11.03
47.22
22.02

8927
86.42
508.53
79.40
689.86
154.77

8946
86.39
112.12
21.59
186.07
74.49

9191
87.55
277.28
132.99
657.06
277.10

9176
86.73
288.61
15.81
245.52
51.27

18522
87.29
490.66
94.81
759.01
194.27

2059
87.30
219.06
65.06
136.38
34.61

5369
85.88
274.28
47.68
200.95
43.34

1650
87.97
569.84
94.38
790.48
182.69

13028
89.85
137.00
17.66
89.57
32.90

7622
85.09
88.74
20.90
56.95
16.90

16756
84.59
361.18
150.11
171.51
41.28

10130
84.36
117.70
66.31
221.33
55.16

3803
85.73
975.63
205.56
722.11
154.02

22985
84.55
83.55
9.87
108.90
29.86

13285
85.94
110.31
17.04
71.38
16.98

11761
86.64
49.48
6.15
68.95
26.33

16958
86.15
61.46
19.84
30.96
13.91

21088
87.30
56.92
8.06
40.35
14.32

15964
84.88
583.51
205.70
1089.69
286.46

22648
92.73
313.31
70.15
490.37
101.26

19822
86.82
994.53
147.26
1418.54
381.93

1651
85.17
577.75
69.32
788.50
180.99

13727
87.53
35.36
28.82
109.18
42.58

13740
84.64
257.51
18.03
221.70
39.96

1652
88.73
476.16
64.04
656.76
161.47



























































































































































TABLE 5B





DICLOFENAC



Atty. Docket No. GENE-077/26US

Doc. No. 44941










Tox


Non-Tox

GLGC
LDA
Group
Tox Group
Non-Tox Group
Group

Identifier
Score
Mean
SD
Mean
SD










13966
89.97
227.19
38.65
159.84
32.03

6278
91.08
58.48
10.10
94.99
25.06

6046
92.65
83.37
33.70
193.87
62.20

8850
89.82
175.34
58.83
99.07
34.66

7937
91.71
34.46
21.21
176.64
93.91

8759
88.36
237.31
41.30
156.57
41.79

6917
88.81
111.53
14.34
176.04
69.10

1698
90.48
190.91
66.62
70.39
93.92

6782
85.13
310.65
67.44
219.45
62.29

21012
92.66
445.05
162.22
203.66
116.06

20864
87.40
3112.64
637.13
1921.03
633.85

11434
86.18
181.39
56.52
324.42
119.03

15124
85.11
1897.22
536.70
1048.98
283.10

21014
92.42
352.43
145.68
149.67
82.43

15189
90.00
4842.58
1706.56
2020.75
1168.41

11755
90.42
343.83
127.98
144.25
136.11

15125
91.33
3102.06
1017.25
1525.20
405.25

17541
91.84
1839.84
669.37
724.33
339.91

67
85.37
1551.30
178.56
1151.89
254.88

17805
96.58
1504.75
444.21
682.13
328.81

1858
88.43
253.42
73.25
153.78
50.88

14346
90.51
174.62
63.19
52.54
90.15

15017
92.48
2241.27
415.11
1149.81
399.55

23987
86.20
596.80
251.48
276.13
75.22

25106
87.02
28.05
3.19
38.61
13.12

20457
86.13
235.87
68.78
395.90
100.59

21145
86.79
76.23
47.54
200.42
66.53

15761
85.67
22.22
16.23
77.85
34.65

13485
85.51
38.32
7.99
57.48
16.43

18246
84.64
100.99
77.72
258.41
95.94

24566
87.61
32.95
21.32
180.03
89.43

7872
92.44
63.92
8.33
112.60
35.96

21977
94.77
30.72
6.14
76.98
45.11

14003
84.35
1575.92
414.94
932.50
241.80

9520
89.02
69.60
25.47
140.86
46.37

1888
84.83
101.45
32.01
52.26
33.35

24568
85.63
78.30
23.68
153.33
67.67

1527
88.63
51.23
9.78
88.23
39.31

20000
84.61
24.08
20.83
127.92
70.97

15379
85.72
33.32
11.21
67.90
28.41

14970
90.99
134.42
36.31
199.60
41.02

8888
88.78
22.26
7.29
48.79
20.58

1729
85.55
81.89
44.56
212.81
80.84

24893
86.30
20.58
18.68
85.55
52.17

4449
86.33
156.15
44.78
243.11
70.20

21975
89.03
357.73
79.92
212.58
62.99

20405
86.92
133.28
70.23
29.80
29.59

20831
89.50
55.62
17.29
138.12
57.86

20803
84.29
737.50
199.95
473.34
124.77

24232
85.94
48.69
39.24
151.29
60.27

1847
86.15
22.26
10.03
62.17
36.21

17401
90.15
1909.24
588.72
1010.74
422.89

725
94.04
33.60
10.05
110.06
46.60

16681
85.68
134.46
57.78
63.59
25.88

1340
89.87
124.95
20.55
184.83
85.84

20682
84.77
226.38
89.62
409.19
108.15

1422
87.45
174.39
46.71
300.07
105.44

22321
85.13
138.89
29.75
94.97
68.63

18597
84.32
987.07
317.42
563.12
200.20

15411
94.83
552.53
112.91
304.39
94.23

16520
87.97
174.46
63.58
88.91
110.98

954
84.94
54.36
5.77
71.54
20.36

15035
89.99
23.84
16.64
124.98
68.66

1894
84.89
294.35
70.10
198.20
72.90

21491
86.07
67.51
10.34
100.55
23.55

1529
84.43
194.31
45.08
294.86
70.18

16982
91.81
1036.49
606.21
130.48
296.12

19067
92.38
76.83
28.49
162.21
46.61

11481
84.61
20.44
15.73
65.86
29.15

7936
93.59
82.66
12.40
137.66
31.43

20523
89.18
1004.68
208.03
579.32
164.47

17088
87.37
98.27
17.79
58.55
31.41

14595
90.21
167.82
59.62
77.65
33.41

11991
89.35
20.14
10.16
46.26
16.40

13542
85.67
321.75
219.70
462.35
148.34

3439
86.94
135.79
26.09
92.94
24.52

3465
92.50
152.39
23.63
263.07
79.12

2128
86.56
97.35
47.36
32.61
16.44

4661
96.19
555.94
110.43
307.06
85.59

21354
89.39
640.85
156.38
418.77
127.04

26083
88.38
403.60
200.12
1199.39
721.99

21976
89.24
462.91
64.44
316.41
69.92

22479
88.52
693.29
140.68
417.80
129.01

3172
90.74
36.28
40.56
206.90
111.79

16521
89.73
453.74
109.04
284.15
76.30

15679
91.36
309.12
62.83
174.14
47.36

24200
97.01
885.64
139.99
426.56
138.77

6758
89.57
59.84
19.18
28.92
13.70

7299
97.61
595.57
144.70
180.65
140.60

665
91.27
849.30
217.79
538.96
94.94

5461
91.99
694.84
296.55
199.69
117.96

7540
97.91
504.78
145.39
158.51
83.92

8065
94.80
236.57
31.67
163.82
37.32

8104
90.62
85.37
9.09
60.70
24.71

8820
97.91
743.55
284.97
139.15
119.88

24197
95.31
82.06
26.90
235.59
79.78

10434
89.97
77.07
35.03
33.65
20.30

10446
90.14
22.58
15.15
127.88
91.52

9079
88.46
1099.28
237.43
736.13
163.45

8099
88.52
72.23
24.65
43.64
14.56

12925
88.48
44.20
4.65
69.36
29.98

12921
89.73
213.56
56.93
102.59
48.69

13013
89.59
32.49
10.44
65.57
21.46

6796
89.30
304.75
71.31
192.78
51.24

22885
89.51
2441.02
725.57
1292.56
483.73

5930
90.51
73.85
24.31
26.85
19.94

5920
97.46
1412.80
271.66
635.94
191.82

12979
89.39
742.50
248.93
366.97
196.56

6014
90.36
183.73
46.62
80.51
44.34

8234
92.38
22.24
6.70
47.07
15.98

16898
90.26
55.03
10.77
78.17
16.44

4330
93.19
242.18
59.53
461.51
139.37

22311
91.96
1255.02
184.06
688.00
158.37

15964
95.49
487.88
126.89
1089.29
286.36

13614
90.06
497.29
91.75
324.46
71.36

23151
90.62
204.97
55.56
355.14
101.19

14450
93.98
45.80
9.30
146.93
73.46

























































































































































TABLE 5C





MENADIONE



Atty. Docket No. GENE-077/26US

Doc. No. 44941










Tox


Non-Tox

GLGC
LDA
Group
Tox Group
Non-Tox Group
Group

Identifier
Score
Mean
SD
Mean
SD










12343
95.55
89.32
12.94
50.29
16.25

6632
92.08
270.94
30.65
167.71
54.30

3091
92.52
531.24
38.99
712.74
159.66

10667
92.09
94.44
15.07
38.95
41.37

18350
92.35
276.28
122.54
92.32
51.93

21025
91.61
267.66
41.37
417.82
107.31

16518
93.89
2054.01
385.94
949.88
306.74

17734
98.79
321.98
49.82
114.29
102.66

17735
94.05
363.65
53.62
178.33
104.47

10241
90.38
114.02
25.12
59.17
24.28

1475
95.17
2063.49
658.77
155.80
379.29

8664
95.29
1388.21
550.83
89.50
215.23

20161
92.68
128.82
47.99
32.65
31.21

25098
90.52
176.46
75.02
35.80
33.18

235
91.30
320.65
25.66
230.34
61.53

17426
90.61
429.40
38.59
568.65
91.40

23679
90.38
78.01
14.28
38.29
19.90

15791
90.79
201.52
56.18
123.78
84.57

2555
91.44
145.97
22.76
85.01
42.88

503
92.18
150.85
14.24
103.15
29.15

25279
90.97
751.86
61.65
549.26
116.47

22412
93.08
196.70
39.42
91.13
45.28

22413
91.53
141.51
32.80
68.54
38.43

25379
91.38
117.64
16.80
71.75
25.39

9224
90.94
418.49
23.57
559.20
140.71

1460
92.12
251.67
29.18
192.46
84.37

25547
92.64
407.00
28.91
267.96
104.45

809
93.23
100.66
16.68
39.56
39.66

25606
92.45
66.28
8.55
40.17
15.01

25747
90.98
80.78
19.33
42.91
38.40

20173
92.18
32.74
11.51
77.29
31.95

407
90.64
264.48
35.26
395.09
94.07

24459
91.21
398.68
40.21
276.39
76.14

24672
92.12
65.39
7.99
39.44
14.11

433
90.88
134.41
23.78
80.86
34.13

605
91.39
38.02
5.26
21.20
10.90

20085
90.68
375.42
39.17
247.93
59.19

1929
91.29
473.25
68.26
870.59
215.67

21211
91.55
548.25
69.20
850.78
217.13

21696
90.92
282.32
32.07
175.33
47.74

15138
91.39
196.35
69.14
471.14
175.95

1409
94.27
290.95
26.81
438.89
99.13

1501
91.02
99.81
25.56
52.93
56.99

17570
93.36
379.60
47.99
240.61
81.89

24649
94.42
65.78
19.06
112.21
22.95

21653
91.50
363.77
66.02
237.45
68.10

19040
91.74
323.49
86.16
184.44
121.72

21400
92.85
211.40
61.58
361.76
72.81

35
91.15
784.74
75.75
1207.71
355.24

1581
91.79
87.16
7.56
66.76
21.04

17226
90.79
433.99
33.61
577.07
118.33

1764
93.42
138.74
17.01
88.17
27.95

20753
90.89
184.62
20.62
119.99
28.26

1141
95.33
394.51
55.69
241.23
66.76

16354
95.03
20.78
35.33
279.68
148.90

21683
91.05
65.76
22.22
27.27
20.99

16520
90.36
123.97
17.89
89.12
111.29

13005
90.56
143.19
30.68
80.63
29.18

16948
95.36
125.57
23.36
317.27
132.70

23033
91.64
422.53
36.80
579.14
117.96

23166
90.98
229.86
42.08
126.92
62.06

4462
91.48
567.85
100.01
952.66
315.50

15421
90.70
562.11
32.28
738.52
153.62

7936
91.91
84.99
15.68
137.74
31.39

17256
91.27
259.66
52.16
429.33
122.40

21672
93.27
447.28
37.64
314.18
77.63

19768
92.02
1218.83
166.71
787.22
172.80

3474
93.52
345.67
22.76
483.73
104.79

12016
91.15
252.53
37.75
465.80
181.24

16469
90.82
1028.80
54.62
1320.78
271.98

13610
91.17
219.12
31.55
365.11
107.30

19251
90.88
562.71
31.16
694.44
105.77

3863
94.79
122.87
17.81
196.59
86.02

4542
90.94
270.11
21.67
180.81
56.07

21029
94.64
126.09
12.20
81.52
23.49

2098
90.58
232.32
22.55
177.21
39.37

6595
91.85
109.39
17.61
68.80
30.49

21388
97.24
104.79
11.52
27.72
24.11

21990
92.48
28.82
20.42
121.58
57.45

5565
92.52
206.09
47.75
389.83
117.52

6736
92.06
131.85
22.79
69.09
33.18

23758
93.24
103.71
16.35
174.80
41.71

23834
91.74
142.01
30.15
74.82
24.22

18288
94.67
217.71
34.85
124.55
43.60

12561
94.73
64.62
15.14
148.52
51.53

11162
91.45
324.91
48.59
495.59
118.35

17938
93.15
319.01
21.59
447.84
95.68

9116
92.64
273.80
27.04
392.81
75.75

7142
95.27
363.26
34.37
610.43
144.19

22415
92.95
375.76
48.28
206.41
158.59

7586
93.24
455.38
78.29
769.55
187.42

11559
93.06
318.57
60.32
552.63
125.46

10004
93.55
78.40
13.45
39.38
19.65

17755
92.18
246.88
32.61
383.76
97.58

9583
91.92
154.31
44.35
55.84
61.67

8665
95.26
2691.53
1101.20
343.63
497.74

8837
91.52
234.73
29.31
331.74
63.42

12450
91.48
35.96
20.64
127.75
69.86

22101
95.58
21.93
23.56
170.51
83.23

7300
93.06
545.82
63.96
744.66
285.54

11618
94.03
224.46
33.16
380.82
110.84

6290
94.18
167.05
14.13
232.79
37.78

2824
91.79
65.68
9.52
100.88
21.89

18642
98.09
492.19
42.17
881.32
192.80

16907
96.36
33.38
19.54
131.32
51.03

6675
92.06
362.12
33.19
548.28
144.52

7049
92.42
153.66
20.90
227.04
46.15

3698
91.97
66.85
13.21
128.16
41.97

4952
91.59
200.30
34.51
106.14
44.92

16003
92.45
198.48
23.57
334.94
104.96

14083
93.91
297.20
43.33
473.74
100.64

24042
95.76
73.75
40.11
21.09
79.30

12551
92.58
95.87
15.38
164.16
42.22





















































































































































TABLE 5D





SODIUM CHROMATE



Atty. Docket No. GENE-077/26US

Doc. No. 44941










Tox


Non-Tox

GLGC
LDA
Group
Tox Group
Non-Tox Group
Group

Identifier
Score
Mean
SD
Mean
SD










15246
95.23
104.02
19.45
63.14
17.15

15277
95.56
1199.28
124.15
856.07
134.65

16859
96.50
245.89
56.54
122.60
47.46

11615
95.14
539.91
16.66
412.37
87.18

19412
96.11
219.32
2.99
183.37
50.07

5297
94.75
143.95
30.44
352.41
109.46

14983
93.93
3935.84
130.20
5873.51
4368.56

17378
95.02
212.42
29.92
131.90
39.98

8664
92.82
246.38
136.12
98.44
245.29

15926
93.75
149.75
18.03
92.20
42.90

2632
94.09
197.64
7.08
154.04
30.64

23625
94.57
138.13
48.08
319.20
91.62

15242
93.06
108.52
12.92
80.06
15.30

19665
95.81
204.31
35.07
88.59
51.54

5496
93.96
268.43
102.39
651.85
166.35

5497
93.48
371.29
150.42
785.01
190.34

14332
95.90
951.74
99.04
604.90
155.26

8640
94.33
66.36
5.36
141.04
58.77

20960
93.54
443.32
50.92
295.69
74.33

8984
92.67
399.31
28.86
308.62
53.47

25377
94.93
56.11
8.35
26.88
13.79

21882
94.51
486.74
47.85
758.64
167.24

24615
94.84
1270.53
105.47
933.13
210.70

20740
93.84
355.52
75.34
210.92
62.22

14996
94.42
206.77
60.78
471.76
163.11

25692
93.75
70.08
7.62
156.74
181.44

1447
92.70
268.68
38.24
201.70
34.81

24590
94.36
43.33
17.37
166.07
70.63

729
93.93
39.48
6.73
77.25
26.06

1929
93.93
476.55
93.68
868.90
216.79

4504
93.75
445.80
139.02
1087.15
323.13

19152
96.14
320.13
96.93
160.67
53.93

19679
94.75
329.18
166.41
754.53
202.48

23307
94.90
142.12
10.93
93.63
26.00

1798
94.69
119.14
47.77
336.07
205.61

19268
95.08
1507.38
104.73
1082.49
316.16

15291
97.74
227.69
93.17
97.65
27.73

13939
93.72
124.71
48.61
325.12
109.46

23698
96.41
147.28
9.50
275.19
124.72

23699
92.76
186.00
34.99
331.03
104.73

6055
95.56
447.44
133.36
1045.52
255.69

13369
93.12
232.19
7.82
184.45
38.15

20780
93.33
152.07
119.67
539.74
202.23

20829
95.84
1805.57
324.13
925.21
315.25

347
93.87
123.84
14.40
78.57
23.09

1479
95.11
92.37
36.66
221.32
62.74

24582
94.45
69.68
15.24
31.85
17.38

21123
93.09
321.71
96.61
661.80
184.33

1877
92.82
314.31
125.56
652.38
170.00

13940
95.72
100.29
27.43
216.02
51.74

16775
94.57
349.58
178.66
1164.24
399.53

989
94.78
38.30
12.87
147.38
60.50

1511
94.81
28.36
22.05
333.19
206.19

21585
93.18
157.63
45.39
342.07
89.26

21586
94.18
70.26
31.01
220.53
67.79

4589
92.97
724.19
281.99
1414.61
338.33

20809
93.33
437.50
34.89
329.95
63.72

23806
94.33
167.38
49.48
459.19
167.23

1081
93.03
278.96
102.51
527.65
126.56

1510
94.93
412.23
94.86
837.44
225.06

14353
95.05
92.56
11.29
55.60
17.26

16070
94.60
96.59
3.46
128.18
52.11

15339
95.47
139.74
20.03
227.15
74.31

474
92.73
490.32
88.10
749.79
130.85

11959
96.86
62.25
10.64
125.40
27.59

18269
94.00
394.51
86.48
771.13
179.69

21672
93.48
474.43
83.01
314.66
77.75

22124
93.60
116.89
12.88
78.17
21.00

1159
93.75
590.14
150.75
991.96
225.85

4473
94.36
67.70
30.48
172.24
49.29

2107
95.11
260.72
38.29
437.31
95.82

19469
95.84
134.02
40.80
367.99
99.90

12276
94.78
72.82
16.26
186.84
61.45

17468
95.87
240.19
29.50
414.57
80.60

17469
93.72
34.52
5.63
72.44
30.50

22537
95.96
40.88
34.27
301.20
137.68

22538
96.29
172.72
15.27
339.80
93.47

17923
93.81
83.10
5.93
58.07
17.69

3863
93.87
25.92
20.32
196.57
85.56

21305
94.06
194.67
46.54
437.54
129.56

17836
93.69
121.68
5.52
90.78
19.92

22669
93.45
61.36
13.28
33.21
14.07

15844
93.36
70.68
14.50
37.72
16.43

21086
94.21
164.64
11.89
103.24
34.93

12797
96.56
166.69
40.58
73.77
27.51

15027
96.86
228.67
10.97
139.90
39.67

12129
96.29
143.53
31.03
645.40
334.58

17823
94.84
683.68
66.28
459.89
95.30

21587
95.08
63.47
12.04
184.59
76.44

24762
97.07
206.67
49.31
926.38
314.75

22180
96.14
145.82
40.45
88.52
23.95

12673
95.84
106.88
41.08
40.72
22.46

18524
94.90
410.60
75.64
697.54
141.17

22770
95.99
460.91
61.30
293.34
60.75

12355
95.20
55.04
2.97
32.72
17.38

3631
97.59
146.49
9.89
93.75
22.59

19347
94.93
82.73
6.92
47.68
20.04

23626
97.10
201.76
49.28
78.54
37.73

23790
96.53
123.00
38.12
63.08
19.14

19936
94.78
417.94
86.08
787.51
166.53

23839
95.17
215.43
62.86
469.65
119.97

16731
95.53
164.04
17.44
86.12
38.17

23843
96.32
187.45
30.50
103.55
28.14

17523
96.17
123.97
10.52
81.13
19.15

2232
97.16
36.74
0.82
24.79
11.77

2113
96.38
222.44
37.93
132.53
29.47

2423
96.59
192.07
14.10
132.98
27.14

11558
96.56
70.08
17.91
160.77
43.05

3145
95.56
152.93
22.06
426.44
138.00

21959
95.41
234.36
36.74
132.11
42.91

16625
96.89
237.89
5.08
180.96
38.01

15232
96.26
257.50
24.61
169.53
35.85

6869
95.20
79.10
7.52
32.43
29.17

16824
96.41
72.56
17.91
227.30
79.50

13104
95.32
217.32
35.96
479.57
130.05

12095
94.99
365.17
58.23
1298.24
810.83

21659
96.32
386.36
74.64
204.80
61.71

3934
95.50
716.78
83.73
1225.51
254.53

3493
96.95
123.15
24.99
61.58
18.38

7270
96.02
267.75
28.36
171.64
36.71

15159
96.02
419.08
74.41
872.31
214.06

17419
95.90
336.07
70.94
197.65
45.14

7896
97.71
173.75
8.10
283.20
65.35

2348
95.81
97.18
36.13
463.64
200.40

1431
95.53
84.36
35.10
462.05
168.52

8721
96.14
35.66
23.53
183.51
66.31

8739
94.99
97.84
18.34
265.76
118.29

5290
96.17
22.52
4.12
50.65
15.13

13157
95.59
99.31
44.78
328.67
105.58

16338
96.77
97.00
8.89
58.64
16.37

7700
96.11
135.98
23.23
80.56
43.28

24592
96.05
74.35
27.61
329.43
142.17

12682
95.62
511.62
150.58
1734.71
588.20

2534
96.56
68.06
11.48
35.59
11.40

8215
95.08
916.05
104.30
1510.03
332.10

13106
95.99
68.92
9.31
37.20
21.98

17223
96.41
1104.50
35.58
868.15
118.29

18418
96.35
370.51
71.34
245.92
41.02

23018
96.05
150.06
18.94
105.15
19.40

18095
95.84
1118.60
126.43
801.84
125.83

5901
96.74
159.91
19.26
91.66
42.91

6629
95.02
314.77
37.87
540.04
121.47


















































































































































































TABLE 5E





SODIUM OXALATE



Atty. Docket No. GENE-077/26US

Doc. No. 44941










Tox


Non-Tox

GLGC
LDA
Group
Tox Group
Non-Tox Group
Group

Identifier
Score
Mean
SD
Mean
SD










17695
99.21
249.77
34.66
668.20
180.15

13563
99.55
355.81
42.90
937.62
228.58

535
98.79
96.78
13.35
38.89
21.47

8325
98.97
99.90
20.29
23.02
13.28

11421
99.31
341.72
20.35
194.63
40.25

896
99.67
191.75
36.71
23.81
21.26

23778
99.03
364.40
111.41
62.36
35.91

7101
98.61
3734.58
971.30
404.36
664.35

17301
98.88
593.47
75.23
238.07
75.73

20886
98.70
94.56
45.86
798.30
318.63

20887
98.52
191.50
66.84
871.37
342.61

20167
99.03
96.57
19.35
24.31
11.29

21651
98.79
211.95
80.37
26.88
22.79

23780
99.43
120.05
46.77
20.80
30.16

13973
99.34
247.62
42.45
33.40
20.04

15790
98.61
112.29
21.33
35.96
18.51

16649
98.52
361.29
75.07
105.60
48.12

16007
99.25
128.45
19.80
21.47
13.08

5496
98.79
219.25
23.70
652.26
165.76

5497
99.28
248.05
17.62
785.70
189.15

17535
98.82
560.61
73.51
244.84
64.97

25233
98.76
62.01
2.18
31.39
13.04

19834
98.76
416.63
72.40
169.62
42.80

16650
98.58
650.04
84.16
256.56
84.67

20494
99.15
297.13
78.23
1055.83
319.86

574
98.73
912.07
67.77
352.32
185.51

455
99.73
571.19
126.84
138.41
189.56

25470
99.79
125.97
5.72
31.22
18.52

7196
98.52
549.97
33.63
177.67
91.15

457
98.61
897.31
151.83
285.93
92.35

15273
99.09
132.66
22.37
32.60
18.78

16674
98.88
180.45
57.13
27.50
22.94

16675
99.00
328.75
104.16
29.43
36.26

699
99.61
74.54
12.40
23.01
34.32

19058
99.06
122.17
14.88
52.83
19.42

1929
98.61
362.48
40.32
869.55
215.82

16610
99.25
316.65
10.82
165.32
65.78

8426
98.67
120.65
12.99
49.38
20.34

16676
98.91
271.51
96.32
33.53
29.58

15175
98.79
116.18
37.93
319.43
57.36

1409
98.73
201.45
22.59
438.68
98.73

15002
98.55
420.90
46.06
135.44
107.26

20828
98.97
1005.07
82.88
323.14
162.23

17516
98.64
304.60
25.38
547.56
127.91

17570
99.82
642.60
29.35
240.16
79.04

16967
99.18
136.29
21.82
33.25
18.18

1462
98.85
1628.61
155.82
431.68
216.05

4450
98.91
136.12
13.21
279.34
61.49

16726
99.09
352.81
48.90
1059.59
226.33

23699
98.82
137.82
16.18
331.30
104.43

7124
99.00
529.78
56.03
1203.74
312.97

16871
98.64
206.80
46.25
79.45
24.72

12606
99.25
130.99
7.64
295.10
99.03

17226
99.64
253.12
22.46
577.21
117.15

17227
99.06
499.29
60.99
982.39
179.08

21122
98.76
534.05
73.79
1146.33
236.16

1877
98.52
254.30
28.09
652.80
169.49

1993
98.94
96.08
5.11
24.14
17.89

1490
98.67
52.85
7.86
20.79
7.83

15437
98.91
193.06
63.58
32.08
19.16

1564
98.88
1294.14
223.87
44.50
193.91

15008
98.94
306.66
36.44
576.58
114.19

23961
98.79
379.40
51.33
785.34
150.80

17661
98.76
580.72
105.12
262.94
68.13

1801
99.06
255.70
34.95
89.47
28.47

20582
98.52
287.05
13.73
487.15
95.43

11079
99.12
328.58
20.15
185.07
44.66

22927
98.64
210.74
21.37
84.48
34.52

19377
99.76
215.21
4.72
109.43
24.18

16082
98.88
129.78
28.85
40.75
17.41

17256
99.09
125.36
14.47
429.20
121.73

17289
99.43
410.41
33.11
1059.53
278.91

17290
99.18
509.27
62.67
1294.21
373.99

17345
98.55
263.93
24.68
127.21
36.29

9084
98.85
145.53
46.17
40.68
17.08

3925
99.00
198.37
20.86
461.33
112.52

18168
98.79
168.33
33.83
38.38
34.80

22618
99.31
117.66
20.00
30.61
11.80

22984
99.34
266.02
27.63
100.26
30.89

22540
99.49
599.57
49.16
1780.91
551.74

17514
98.82
358.61
50.80
817.29
188.14

5206
99.12
507.97
41.61
176.59
77.00

894
99.15
1783.60
174.73
652.12
224.42

23532
98.88
124.66
30.17
22.30
16.51

23533
98.97
204.49
10.44
83.11
38.10

23958
99.06
203.79
34.98
61.18
25.94

5952
98.82
255.47
23.17
83.50
40.80

9309
99.67
329.43
22.61
174.98
41.72

12616
98.91
144.41
20.14
60.76
20.41

3269
99.03
366.86
112.74
81.91
44.65

21959
99.40
327.36
32.91
131.72
41.66

3572
99.03
172.95
63.76
38.98
21.80

410
99.00
465.49
50.55
1037.75
225.86

895
99.21
668.52
123.70
177.65
76.45

23810
99.21
84.71
11.03
27.57
13.19

7665
98.91
723.79
74.48
290.61
94.65

3083
99.21
158.35
14.18
74.00
21.63

3584
99.00
203.98
20.49
61.56
30.32

16884
98.79
1053.19
76.80
1909.01
474.48

6022
98.85
414.10
35.32
217.84
63.57

5929
99.28
168.33
15.69
36.89
20.17

16913
99.15
613.71
52.52
1257.86
287.28

3099
98.85
554.56
35.33
894.32
163.71











































































































































TABLE 5F





THIOACETAMIDE



Atty. Docket No. GENE-077/26US

Doc. No. 44941











Tox
Non-Tox
Non-Tox

GLGC

Tox Group
Group
Group
Group

Identifier
LDA Score
Mean
SD
Mean
SD










16087
88.96
147.89
19.38
87.68
30.47

13934
92.71
180.15
27.02
68.19
54.80

17268
90.32
317.63
20.88
445.26
113.01

12366
88.81
402.17
110.21
266.10
83.20

9332
90.02
39.70
10.71
102.53
42.52

783
90.47
122.89
16.37
83.12
25.36

2574
88.38
110.78
17.74
72.92
19.69

19890
89.34
114.05
11.07
80.22
26.45

23115
96.27
218.73
37.94
504.64
158.87

15028
89.26
172.40
66.68
366.39
126.77

17921
87.55
119.45
22.88
195.17
71.34

16116
82.88
61.16
6.60
78.82
19.59

1453
82.50
89.33
27.93
52.20
26.79

20896
85.56
83.44
18.33
141.36
40.26

18043
84.79
99.39
38.52
41.39
22.49

25235
90.29
187.30
55.17
84.23
49.84

18246
82.90
113.80
43.37
258.83
95.85

28
87.68
260.01
111.55
531.88
180.16

24631
84.37
36.22
7.30
21.68
10.08

20149
89.08
2751.06
487.03
1546.67
703.21

25364
86.35
104.43
36.32
56.18
57.10

2079
84.04
190.93
36.44
304.09
90.50

25399
83.38
392.81
122.41
185.18
190.17

8829
86.69
454.94
86.93
283.22
86.03

24566
82.52
103.57
24.04
179.92
89.90

5837
90.29
586.00
88.17
850.13
202.51

5838
83.75
443.80
68.13
652.08
145.88

3609
83.65
185.56
111.40
434.86
172.76

25589
82.84
220.29
33.93
150.66
41.90

25647
82.56
437.20
166.12
209.40
238.75

25662
85.35
210.06
62.21
117.83
97.01

25686
82.52
899.95
98.60
749.37
152.25

20617
86.99
425.33
118.93
206.81
228.40

22219
84.55
61.94
15.60
37.48
62.65

25777
84.09
809.02
317.73
441.84
253.01

24431
84.79
131.55
52.25
59.17
87.36

24438
85.26
89.77
17.89
143.35
40.49

24567
87.37
34.58
19.86
111.01
63.84

291
88.11
145.69
31.30
224.02
46.48

8426
83.89
77.60
12.47
49.42
20.66

1535
85.53
44.01
11.60
85.58
31.50

23781
82.57
67.71
7.21
85.97
27.49

10071
87.87
177.18
42.47
350.75
123.95

25921
86.50
50.94
6.86
28.33
16.05

15330
84.84
36.66
19.02
81.96
24.24

19003
84.31
141.69
17.27
102.43
33.94

19943
88.92
210.88
54.72
366.97
116.34

22434
83.07
68.42
18.29
43.74
20.91

1409
84.89
299.53
60.23
438.92
99.13

16227
83.44
152.60
38.37
88.54
40.73

15191
84.83
3728.02
829.67
2407.15
1233.18

15642
84.42
750.42
224.71
433.34
115.91

4280
90.44
2201.62
242.72
1538.01
535.02

15039
89.11
118.00
47.79
272.70
91.84

1946
89.66
64.08
9.55
39.55
12.41

4451
90.01
192.78
31.81
290.75
72.79

17357
85.93
89.91
76.51
270.04
95.73

21193
84.95
50.26
5.87
33.25
14.85

18716
85.36
53.32
13.29
29.64
11.72

21400
89.05
217.92
45.44
361.83
72.95

187
87.75
202.63
72.64
75.52
52.59

20555
90.10
70.09
13.74
116.38
35.29

15489
91.68
96.70
14.21
141.82
34.76

6577
85.16
122.77
12.31
178.46
48.88

439
84.00
28.56
7.59
45.33
16.65

16205
83.86
1418.72
140.70
1122.95
425.85

989
83.64
106.37
20.93
147.41
60.77

21147
88.84
223.85
45.68
361.29
80.82

3512
83.28
129.79
11.72
106.87
19.31

2439
88.38
98.92
17.04
147.82
27.80

1529
82.83
226.95
35.67
294.63
70.00

20582
85.77
353.36
43.17
487.57
95.61

22562
83.52
46.00
10.04
27.10
13.28

23000
84.06
41.94
3.47
35.87
9.55

13974
82.76
355.79
36.94
315.24
173.81

22781
82.81
229.37
43.64
143.62
72.36

6049
84.79
805.83
63.05
688.66
113.01

1644
88.98
444.20
28.05
560.84
126.28

4373
83.62
166.60
16.69
133.42
26.68

13610
82.68
257.86
38.84
365.13
107.29

8599
86.17
222.32
55.03
389.47
116.57

3870
84.58
91.07
23.43
152.03
56.60

3465
82.92
173.23
36.47
263.26
79.05

2191
83.36
42.32
13.37
22.22
8.81

22783
83.50
566.84
84.58
347.17
212.46

15303
85.43
68.69
8.52
95.79
28.70

22386
86.89
148.02
26.48
252.07
98.25

11653
92.35
269.88
75.12
561.59
194.36

18447
89.54
602.70
133.92
1098.88
276.35

14410
89.40
133.78
15.12
184.02
38.17

18285
94.66
425.99
37.64
688.90
152.65

17363
88.40
836.27
72.73
1036.86
193.05

2282
91.08
90.03
26.05
212.24
65.58

24233
90.10
411.31
46.44
567.75
108.66

2964
89.74
207.16
29.50
295.32
59.24

3407
88.84
48.51
16.65
22.82
14.74

26133
90.48
395.06
106.85
188.25
84.91

21105
93.53
188.56
23.10
300.96
60.90

2912
90.60
1472.50
191.19
2440.94
597.53

15904
89.80
81.53
10.99
56.69
23.58

11326
90.95
191.68
30.66
319.99
87.52

7825
89.05
120.48
23.58
70.06
27.39

5430
89.98
60.14
21.49
135.42
58.52

26173
90.08
265.60
25.65
171.81
48.30

10069
89.56
267.84
30.41
197.01
47.53

8944
89.19
61.50
9.22
40.45
16.66

22929
89.40
330.05
142.49
797.70
312.82

11075
88.93
99.43
19.68
58.88
21.11

10849
90.74
108.53
15.45
73.98
26.10

19930
89.51
49.33
6.03
28.71
11.78

11198
90.47
66.09
9.13
43.72
15.80

12945
89.02
168.30
33.30
289.09
69.55

13020
89.44
111.03
18.18
74.64
23.70

9504
93.05
71.31
11.15
48.44
20.69

2264
91.41
134.06
11.12
101.59
24.28

165
90.11
145.31
43.89
58.63
36.81

5531
88.65
41.41
2.58
32.86
11.29

18522
94.29
477.42
63.58
759.42
194.18

1649
90.83
363.72
54.17
561.87
156.83

22271
91.08
114.39
43.35
247.46
57.55

16887
89.89
107.51
10.43
154.97
45.52

21253
88.40
346.51
35.62
476.31
102.82

23748
89.13
67.98
29.82
154.15
63.22

11618
90.72
179.78
41.87
381.46
109.96

24165
88.10
119.54
15.30
72.25
33.85

3279
91.44
394.77
37.63
552.89
119.12

11232
90.98
413.94
45.20
291.89
76.35

22985
89.78
61.31
12.25
109.17
29.50

6630
89.22
1020.91
101.07
1270.63
199.90

11968
88.75
161.58
45.48
277.70
74.95

13457
90.47
108.45
8.39
75.26
26.79

14978
90.59
115.74
17.67
69.00
30.46

4987
89.86
161.07
15.62
234.26
58.10

150
89.74
44.55
4.99
31.82
9.68

12684
89.68
216.15
19.77
153.61
44.73

17833
88.80
178.08
13.51
132.77
41.58

13611
90.71
141.12
35.24
249.73
83.52

6886
88.66
74.86
18.86
44.24
15.63

9035
88.25
93.11
9.82
126.24
27.10

11866
88.65
193.70
21.24
133.49
72.18
















































































































































































TABLE 5G





VANCOMYCIN



Atty. Docket No. GENE-077/26US

Doc. No. 44941











Tox
Non-Tax
Non-Tax

GLGC

Tox Group
Group
Group
Group

Identifier
LDA Score
Mean
SD
Mean
SD










15132
97.42
556.28
65.10
314.76
79.74

15955
97.18
283.29
93.14
689.98
159.09

14677
97.45
165.57
17.88
69.76
30.34

15004
98.30
770.01
324.95
154.94
147.16

7307
97.18
92.05
30.06
28.29
16.83

5208
96.88
256.89
147.95
977.27
392.75

17361
96.18
28.93
11.40
138.07
55.62

6614
96.21
183.60
64.33
438.27
117.69

6405
95.90
202.88
43.49
403.99
105.10

21078
95.42
318.58
74.48
629.47
142.80

20716
94.54
407.31
96.00
723.45
165.86

20886
93.62
80.08
149.92
801.44
315.41

20887
93.22
168.32
177.62
874.64
339.69

15662
97.06
163.93
19.51
93.95
27.11

10015
98.18
563.53
77.79
229.49
80.02

10016
97.79
518.59
107.36
208.97
79.42

16350
97.91
140.55
45.36
43.66
26.40

16351
93.86
224.63
88.04
65.23
32.31

18453
93.28
88.03
19.21
218.34
72.82

472
99.03
243.72
82.34
732.71
178.26

28
95.42
145.06
98.13
532.55
178.76

18750
96.91
341.14
53.21
168.24
62.25

968
95.78
29.31
9.99
81.27
22.89

17159
93.07
1527.58
315.26
787.22
213.24

574
98.51
1391.19
255.85
347.01
165.41

25415
96.36
32.48
27.25
161.84
72.36

25419
96.81
31.08
22.07
149.42
67.18

25467
95.21
320.12
106.53
737.06
245.44

5838
97.36
301.27
68.21
652.99
143.93

7196
93.65
574.19
128.31
176.23
87.09

15135
96.00
1256.66
187.64
774.12
176.10

3430
92.98
1105.90
415.94
451.02
154.70

1546
94.36
122.71
35.02
244.53
64.28

22675
98.67
118.93
55.69
28.15
15.37

1551
97.57
44.36
13.06
122.96
105.41

20884
97.39
71.11
94.30
738.14
289.89

20810
94.99
2328.92
400.59
1448.17
356.77

15653
94.60
1852.53
268.29
1284.72
282.04

25691
92.89
1341.48
251.62
775.97
169.40

20848
97.57
1070.75
145.58
548.58
158.87

25702
97.97
1078.58
151.22
623.33
125.71

10109
97.82
1679.00
1324.10
1190.54
238.15

25718
93.13
683.37
89.19
419.94
86.09

4441
96.54
1550.03
172.22
1061.96
187.57

13646
97.06
1401.63
217.84
815.38
181.16

19824
96.75
72.58
25.39
216.05
72.84

25802
96.54
845.70
105.36
521.07
117.59

16245
97.42
69.92
89.96
412.35
124.91

24770
94.57
60.89
37.80
244.14
106.68

457
94.10
658.43
132.04
285.53
94.14

19679
97.03
257.82
106.61
757.15
199.62

19943
95.78
148.72
40.47
367.33
115.68

16150
95.51
274.61
48.72
520.97
135.92

1809
93.44
275.58
89.54
34.04
133.49

645
97.85
22.16
19.08
135.98
49.42

21950
94.42
493.04
82.54
812.67
152.27

1501
93.65
224.82
95.99
51.78
53.84

4449
94.72
115.32
31.26
243.54
69.77

15002
98.27
571.32
171.32
133.34
101.38

15003
98.33
454.25
157.22
31.60
90.05

2109
93.19
1476.03
210.52
911.33
166.60

7197
92.89
474.21
129.15
188.31
86.11

1462
93.19
954.56
196.88
432.34
223.37

17198
94.10
174.10
183.51
910.03
269.39

16726
93.28
486.85
132.99
1061.35
225.30

17807
97.06
1436.26
188.44
842.88
218.96

17357
97.12
50.26
40.35
270.21
95.37

23651
97.51
3310.38
741.12
733.68
659.72

20885
97.75
86.92
67.69
590.89
224.65

24563
94.16
24.77
36.61
322.32
110.47

24564
94.35
97.01
57.45
615.45
190.61

17104
93.04
855.38
133.20
481.52
111.05

19040
93.71
706.16
170.63
181.75
113.25

20816
98.12
1222.71
372.23
405.88
177.08

1549
94.54
114.38
21.37
201.87
48.01

18629
95.30
1002.30
147.79
653.52
144.64

20481
97.51
104.65
12.92
201.59
40.93

1463
93.38
1519.27
270.01
664.00
313.79

20849
93.47
566.69
140.91
281.36
87.91

16204
96.97
1384.43
194.54
865.08
172.51

16929
96.69
1743.43
228.03
1095.03
207.82

17401
93.04
2406.67
718.29
1005.70
409.58

23854
93.04
1043.25
158.05
521.42
171.16

646
98.30
83.09
64.74
528.44
191.02

1993
93.77
93.20
19.75
23.92
17.40

11849
96.69
1317.16
211.89
773.90
177.28

1141
96.60
436.63
69.87
241.00
65.86

1422
97.39
102.77
18.65
300.99
104.53

1508
95.33
269.31
91.76
654.52
194.51

17284
96.30
121.14
16.57
218.48
58.98

22321
97.54
321.53
86.82
93.58
65.67

18502
93.98
124.08
73.30
765.24
269.62

4327
97.66
213.79
52.87
82.05
36.57

7489
93.33
22.54
9.10
72.97
31.20

1382
96.51
90.08
11.91
49.24
15.74

1564
98.51
924.30
353.42
42.69
192.73

2465
95.39
67.67
23.37
131.86
26.71

23961
97.00
451.82
79.40
786.13
150.14

4360
96.45
162.70
43.83
333.15
72.47

13647
96.15
1685.74
240.33
965.67
279.68

19768
92.92
1379.96
280.91
786.38
167.89

21695
93.92
142.04
27.58
49.80
30.26

15876
97.45
2120.60
249.97
1361.28
237.57

3870
93.84
56.07
22.14
152.24
56.26

17325
98.06
566.28
234.26
55.28
99.39

18751
97.72
1011.52
204.86
514.43
129.28

21509
97.18
356.98
61.72
91.05
94.62

6039
97.88
656.26
129.35
309.49
76.09

12332
96.54
184.06
71.27
549.08
160.38

23093
96.03
106.37
12.36
186.37
43.33

17514
96.57
454.63
81.01
818.94
186.75

23758
95.45
88.49
20.75
175.01
41.28

3069
95.27
95.79
24.02
181.96
42.00

3121
96.09
495.24
184.53
1291.00
320.21

22592
98.27
1074.58
313.00
224.39
160.59

7964
96.81
121.19
45.58
325.72
93.20

21797
97.79
751.43
151.51
331.28
105.33

24211
97.63
363.77
83.59
128.82
74.63

3610
95.33
430.67
215.13
1122.89
327.90

18503
97.69
87.10
55.82
769.37
319.53

2125
96.27
190.48
54.94
69.66
70.52

4856
97.51
225.36
26.28
113.64
35.44

10983
98.15
26.59
14.05
150.11
58.58

5199
95.57
231.08
78.06
560.22
167.42

10839
97.69
522.43
88.99
296.05
56.93

14929
98.12
2704.92
750.05
750.97
385.07

736
97.15
1042.03
152.24
635.04
130.62

11205
97.54
218.47
59.26
555.88
160.64

4445
96.39
803.11
134.14
477.79
96.26

20873
96.03
3443.13
613.84
2121.19
488.68

3834
96.75
132.71
15.15
223.31
50.13

19188
97.42
527.70
117.58
1311.37
331.19

18612
96.69
212.66
25.56
128.14
27.31

24108
96.54
257.44
35.85
149.90
36.24










































































































































































TABLE 5H





S2



Atty. Docket No: GENE-077/26US

Doc. No. 44941











Tox
Non-Tox
Non-Tox

GLGC

Tox Group
Group
Group
Group

Identifier
LDA Score
Mean
SD
Mean
SD










15171
84.95
419.71
164.49
224.19
79.03

3816
85.24
464.69
118.27
309.23
67.90

26319
82.82
76.87
13.91
48.99
22.63

3091
81.96
479.65
112.26
714.58
157.74

352
82.73
127.68
32.93
81.40
54.77

1698
95.69
476.04
217.52
66.29
80.81

4392
80.03
3259.52
1607.18
2948.56
850.63

18259
83.24
519.34
278.97
208.74
145.33

19252
88.05
1076.93
223.42
699.29
132.43

15295
81.48
211.13
62.16
133.01
44.12

15296
81.36
211.59
76.79
126.72
51.34

20795
89.27
395.60
169.67
145.49
73.47

22352
86.44
284.98
97.78
147.56
105.44

22625
82.55
203.73
89.37
109.20
101.37

11840
85.36
122.01
37.49
67.99
20.17

20801
80.66
227.27
55.54
150.06
48.38

353
88.14
319.61
99.94
169.89
88.77

354
85.33
388.15
110.75
216.19
104.30

11755
86.73
376.55
164.92
141.89
130.13

17736
80.81
182.31
146.86
69.27
157.44

17541
92.42
1949.27
848.82
715.92
315.92

1537
90.76
257.23
167.48
25.97
54.59

1399
87.58
525.84
225.50
194.83
76.18

25064
80.28
2074.70
700.66
1115.73
310.65

25069
90.61
345.14
130.65
122.58
64.89

14346
81.56
203.45
102.23
50.68
82.80

14633
85.60
234.78
89.03
88.80
83.21

14347
85.85
400.13
169.40
165.49
124.98

25098
79.90
93.64
67.91
36.16
34.64

19433
81.22
249.89
135.26
95.01
61.36

15750
79.71
47.36
18.14
21.51
14.89

18300
79.97
206.84
132.88
487.38
169.27

25253
80.87
356.00
58.62
290.00
68.77

22412
80.58
140.47
30.74
91.22
45.78

22413
81.99
109.06
23.31
68.44
38.34

15069
82.45
156.30
69.08
89.93
53.08

18990
90.28
86.48
40.00
20.60
20.74

15470
81.55
446.71
86.23
334.66
93.68

4956
81.16
164.38
98.90
69.29
29.02

12978
81.88
178.61
68.70
96.11
47.83

24484
80.31
66.39
12.02
92.42
26.08

18011
80.90
67.94
34.59
27.48
28.90

1439
81.65
147.91
28.34
225.64
53.27

25902
82.59
112.19
22.14
159.55
48.13

20082
81.87
91.12
20.35
66.30
28.33

14970
86.63
129.68
33.81
200.04
40.68

20802
87.50
435.04
93.17
244.10
82.49

3016
80.37
4148.89
2854.50
3998.79
1813.37

4235
82.01
583.10
107.05
411.30
95.75

8211
81.93
3918.21
2663.36
3502.10
1459.77

16726
82.61
775.42
171.63
1060.46
228.56

20841
81.92
143.31
33.78
95.74
25.14

18449
80.81
729.28
116.57
610.20
123.99

24900
79.96
488.04
143.15
638.38
155.04

20443
81.46
161.56
35.20
113.93
27.53

20803
91.23
799.85
172.29
470.96
121.12

1558
81.39
321.49
76.64
200.81
63.40

405
83.80
132.67
34.34
208.32
63.52

21239
80.43
229.76
97.82
106.28
59.82

1410
83.60
34.40
19.24
89.22
43.41

21147
79.81
268.70
99.55
361.28
80.70

15032
81.33
183.52
59.26
265.32
74.21

21038
86.52
242.02
70.96
103.82
41.91

21039
86.46
195.33
59.92
78.33
43.60

18597
80.46
1089.16
347.96
559.47
193.08

19254
93.32
450.27
111.28
243.51
70.21

4592
80.90
249.94
54.72
177.09
36.45

24377
81.36
145.34
38.16
203.71
49.55

15574
80.39
173.01
25.25
215.63
33.89

24033
81.42
259.06
80.18
347.59
75.37

24235
84.25
1152.14
527.92
473.62
203.30

13609
89.08
127.39
51.22
239.16
63.31

13610
85.29
239.35
63.10
365.74
106.91

12848
83.34
297.78
63.29
431.68
92.39

21305
80.36
272.12
81.64
438.75
129.17

18967
80.39
337.68
55.22
487.47
203.79

2979
81.44
245.69
57.16
282.97
42.84

18396
83.12
111.98
44.34
66.03
26.28

16039
82.15
697.44
191.99
482.12
97.81

2924
82.14
213.38
38.03
154.90
50.18

13349
81.88
200.63
47.75
132.83
38.04

3822
83.20
1346.58
265.08
925.26
284.34

22501
84.65
492.96
180.94
251.35
55.90

26083
82.21
1826.66
491.08
1187.90
721.09

22656
82.26
199.64
38.98
123.05
53.17

12331
83.65
391.83
107.95
591.12
141.29

24192
87.16
197.41
91.63
74.59
46.05

4944
86.29
211.24
47.96
119.87
58.35

21513
83.49
75.92
24.74
120.24
29.73

23314
85.33
562.77
365.79
72.82
278.18

24246
83.14
450.51
118.31
305.90
95.78

3053
83.04
154.60
38.76
96.88
33.21

20035
86.06
430.87
178.90
180.79
99.78

23917
92.66
1506.66
499.29
718.95
184.83

22414
82.49
91.38
20.25
62.37
32.42

21632
83.14
122.74
47.18
31.65
49.47

20804
87.44
1875.82
427.00
1059.53
324.98

2242
86.21
1439.71
469.38
2188.97
546.30

20086
82.52
270.19
119.18
107.78
72.84

22502
85.39
158.92
82.43
53.23
48.19

12812
85.49
52.00
16.73
97.11
34.86

8283
82.11
273.51
122.40
128.67
44.94

8820
84.40
597.48
343.99
137.31
114.55

16718
83.02
771.65
152.36
1131.02
291.60

2059
87.00
193.67
24.25
136.36
35.16

12979
82.91
827.72
363.04
363.63
189.87

17850
82.65
478.49
74.33
350.42
68.02

6014
89.18
250.89
107.92
79.07
39.75

11429
83.43
212.12
34.36
269.26
41.65

15382
82.29
978.24
634.06
120.29
179.44

5863
84.29
88.93
23.67
139.47
34.68

15964
85.54
674.79
216.85
1091.41
285.42

19184
82.21
185.49
78.89
78.67
75.04

22197
83.56
181.41
38.36
111.12
43.86

13611
82.20
130.10
78.13
250.25
82.89

13607
82.37
34.94
7.53
22.53
9.86

6765
82.55
507.81
142.81
730.21
168.95

1651
81.95
628.76
65.78
789.11
181.29

17892
83.55
153.95
40.92
306.40
134.74

23435
82.42
143.51
70.04
32.23
45.61

20895
83.42
188.70
90.22
303.22
74.58





























































































































































TABLE 5I





TUBULAR TOXICITY



Atty. Docket No. GENE-077/26US

Doc. No. 44941











Tox
Non-Tox
Non-Tox

GLGC

Tox Group
Group
Group
Group

Identifier
LDA Score
Mean
SD
Mean
SD










15955
74.37
490.57
195.79
701.12
150.24

5601
80.41
570.05
236.57
903.71
216.83

4440
73.83
195.43
69.44
295.13
82.26

14095
74.13
270.72
76.14
358.04
71.36

6046
74.40
135.01
56.88
197.57
60.74

11164
74.38
332.33
139.83
485.92
129.73

3091
76.77
535.18
168.51
724.55
150.86

3467
73.54
461.68
163.07
646.99
168.60

16314
75.54
110.20
71.12
41.23
39.76

18272
75.77
134.16
52.28
179.70
40.85

1698
76.15
259.77
253.73
57.45
46.82

15295
71.74
190.57
76.92
129.84
38.91

15296
72.54
195.64
91.33
122.82
44.73

17734
71.52
279.85
275.77
104.11
64.03

11840
71.83
96.37
36.59
66.61
18.13

15701
71.80
47.52
19.49
30.00
11.38

20801
73.86
215.55
69.25
146.31
43.89

353
72.64
298.13
157.91
162.53
75.73

354
72.87
373.67
185.53
207.02
87.88

17541
71.55
1248.41
894.94
692.89
234.54

1399
72.16
341.24
183.76
188.40
64.08

17301
71.34
325.89
119.33
233.24
70.86

20161
73.64
80.23
54.25
29.99
27.33

18300
72.65
285.09
167.97
498.43
162.68

11483
71.74
141.85
116.98
51.93
39.61

25198
72.83
49.29
21.40
25.88
13.23

2555
74.79
134.28
53.66
81.97
40.03

28
77.64
315.43
178.66
545.11
171.54

20458
74.64
271.25
94.25
374.56
94.29

20298
71.28
409.64
131.62
556.86
153.30

1460
73.32
302.66
131.64
185.02
73.88

14121
71.92
492.14
155.94
350.47
102.93

25567
71.99
715.87
268.63
465.90
181.93

3430
71.70
651.98
230.79
441.70
152.47

24234
72.61
391.71
269.60
175.87
68.56

16012
71.84
101.22
49.06
62.06
26.39

12978
71.54
152.96
71.09
93.05
44.29

25777
71.29
882.80
556.03
413.32
182.36

10887
75.63
42.57
19.85
65.79
22.04

24496
76.32
72.15
40.14
113.67
35.59

24770
71.76
149.41
95.43
249.51
105.16

18000
72.20
1021.88
441.49
1515.83
541.89

794
71.77
143.65
62.53
212.58
63.38

811
73.98
180.08
66.32
257.46
56.05

812
76.93
105.28
36.08
153.16
36.80

15330
73.67
58.68
23.74
83.24
23.75

19679
76.55
499.67
216.56
771.74
190.03

20082
73.54
102.09
38.64
64.04
25.68

20056
71.66
246.08
95.02
318.69
67.21

14970
76.36
144.83
50.08
203.14
37.69

15110
73.25
505.21
179.79
713.50
178.30

17684
71.81
170.05
66.05
237.48
55.17

15299
75.82
120.11
57.11
72.50
54.88

15050
73.63
541.66
141.16
688.65
174.84

17196
71.36
99.85
27.32
128.69
24.41

15039
73.52
177.90
93.67
278.20
88.82

409
73.83
746.67
188.60
947.21
178.98

16726
72.69
800.41
280.17
1075.60
214.53

17357
71.23
178.34
104.23
275.09
93.07

15111
73.26
785.18
294.19
1118.72
264.03

15112
73.00
1338.19
433.49
1860.86
460.35

20803
71.57
629.95
256.03
463.60
103.39

20753
72.02
157.80
39.75
117.80
25.81

21654
75.86
551.82
178.12
366.37
116.43

6641
72.55
304.37
93.60
402.49
84.73

21239
75.09
197.82
98.17
101.23
52.71

16775
71.26
800.69
398.31
1188.38
388.39

1884
71.12
208.69
48.64
169.12
34.33

4198
72.64
603.75
177.10
780.82
177.13

21147
74.26
274.00
87.67
366.40
77.47

15986
73.46
214.52
95.30
326.69
83.60

15032
78.99
176.05
67.41
270.72
70.95

4327
72.45
133.62
67.44
79.38
32.50

21683
72.77
53.28
30.07
25.72
19.21

7489
75.92
37.03
20.90
75.16
30.46

7784
74.81
532.12
161.80
699.90
128.21

23961
71.60
644.10
203.09
793.72
143.04

1529
78.54
203.36
69.83
300.60
65.42

10464
72.19
90.84
30.16
122.79
30.91

4462
74.15
658.57
311.71
971.30
305.73

16312
76.70
108.77
62.22
45.54
31.63

7936
75.30
107.61
27.73
139.51
30.80

4360
74.46
253.43
81.01
337.54
69.89

5384
75.41
90.12
61.25
28.04
36.31

24235
72.19
833.55
457.25
456.15
168.02

17256
71.98
313.90
166.05
436.12
114.73

9905
73.49
576.55
180.69
755.53
145.11

18128
72.27
163.39
43.26
205.45
45.93

4463
74.19
86.69
63.34
154.87
56.17

1159
75.77
712.96
239.20
1011.11
211.67

4473
74.68
122.22
55.23
175.55
47.15

17682
78.29
507.13
211.81
773.82
172.62

13609
76.92
163.77
55.10
243.19
61.57

13610
78.86
260.43
88.06
371.73
104.73

18906
71.16
164.62
90.59
266.79
88.78

23783
72.45
376.37
89.08
460.99
76.97

9053
73.45
190.10
53.40
240.11
47.80

21305
73.82
298.39
90.29
446.76
126.64

12031
71.64
192.48
67.66
134.78
33.69

18396
72.13
106.40
55.73
63.70
20.92

18360
71.37
154.88
51.56
206.67
54.97

21341
73.57
463.05
136.52
620.74
147.68

13349
75.79
183.06
52.76
130.07
35.07

23005
75.72
694.34
270.62
901.12
190.44

22681
74.06
507.76
361.88
202.52
156.32

22554
75.51
387.64
139.23
544.84
133.65

22612
74.35
330.37
111.38
469.08
108.90

18337
76.16
1120.66
375.56
1593.01
326.83

21157
74.05
549.82
137.16
428.96
84.27

4944
80.39
210.32
80.95
114.51
51.54

23261
74.04
1121.37
378.88
1550.48
320.61

18271
74.07
587.16
201.63
753.02
149.78

23546
73.90
549.94
189.79
721.45
151.51

23314
77.31
506.68
414.87
47.74
245.21

2702
76.15
433.75
181.46
270.79
68.25

20694
76.61
688.47
220.38
933.57
204.17

23917
74.67
1098.72
458.70
701.40
145.27

21632
77.91
98.75
74.15
27.96
44.65

17524
77.19
794.19
308.69
1135.59
259.89

17550
77.50
879.01
298.17
1290.95
333.72

3995
74.45
447.64
135.49
615.34
139.51

2242
82.51
1386.39
557.25
2237.29
505.01

6674
74.54
1776.75
507.96
2387.57
539.31

3874
74.97
637.40
187.18
871.96
181.31

2370
74.04
876.31
227.54
1077.70
174.57

10818
76.28
251.30
167.92
480.32
177.62

17755
76.09
278.24
99.73
390.16
92.04

5900
74.94
205.87
72.79
265.10
54.52

8721
75.64
109.17
63.60
188.60
63.43

18792
73.60
98.71
33.22
136.87
36.34

9079
74.38
581.21
173.48
749.66
159.41

9673
74.72
35.38
16.35
65.52
26.97

9781
74.13
82.19
36.96
124.27
34.07

16813
73.61
231.75
81.80
331.59
80.11

11937
74.01
101.08
23.16
79.06
19.14

3610
78.84
722.35
368.53
1146.23
311.02

18522
74.81
548.81
212.63
772.15
185.03

5923
75.17
439.81
176.29
606.68
131.73

22101
73.80
85.02
82.10
175.65
80.50

11618
77.12
257.75
117.01
388.64
105.31

12979
73.96
632.88
317.40
350.02
172.71

16756
73.57
240.33
81.11
168.05
37.88

3916
75.59
472.89
195.40
675.96
140.94

10130
74.03
167.62
59.58
224.47
53.57

4291
74.22
180.51
91.51
288.32
84.88

10985
78.22
735.68
231.86
1069.30
225.65

5863
78.76
96.37
30.11
141.94
33.29

15964
77.61
745.68
276.40
1111.07
273.12

19184
75.15
190.82
119.94
71.94
64.87

22569
74.81
417.82
171.09
628.93
157.19

6765
74.29
544.27
202.38
740.81
159.94

23435
77.07
107.07
69.42
28.24
40.65

13618
74.08
137.35
40.63
99.14
26.21





























































































































































































TABLE 5J





GLOMERULAR INJURY



Atty. Docket No. GENE-078/06US

Doc. No. 44941











Tox
Non-Tox
Non-Tox

GLGC

Tox Group
Group
Group
Group

Identifier
LDA Score
Mean
SD
Mean
SD










1688
88.99
985.99
996.97
5062.79
2851.87

11967
83.98
1036.36
258.41
1617.83
495.77

11610
79.19
368.78
38.57
303.07
70.24

1689
82.61
1224.06
1215.72
4062.22
1648.08

3615
82.64
103.67
34.57
197.88
61.86

9391
80.47
668.60
95.16
863.78
204.49

16881
76.78
442.88
61.71
533.80
110.83

21302
76.45
175.69
45.11
245.52
73.79

4312
85.90
125.63
20.84
65.92
30.34

20864
84.41
1168.66
229.66
1938.09
636.48

20801
76.44
195.17
43.72
150.37
48.96

11136
78.76
832.19
153.81
1147.90
344.29

11137
76.72
1138.55
218.66
1635.07
463.88

20876
80.75
1429.42
179.01
2010.11
495.92

20713
79.77
321.28
83.43
211.11
121.91

494
84.50
1183.13
183.42
774.08
266.75

20714
80.11
251.69
65.33
169.88
95.99

1247
78.73
839.48
329.16
1582.78
517.89

495
81.45
270.73
74.76
127.48
87.19

21914
78.27
520.42
91.18
411.11
83.67

3454
77.15
100.75
18.92
75.51
30.81

4011
76.93
792.94
249.01
476.14
218.70

20741
80.44
223.50
26.65
175.19
43.80

3608
78.46
198.11
80.98
358.92
138.13

28
76.62
309.69
141.93
532.57
180.04

25290
76.53
233.26
73.75
140.64
55.93

108
76.86
612.75
314.84
275.19
150.60

25366
78.91
89.96
46.99
44.98
55.94

25468
90.11
657.58
614.46
2655.18
1078.33

25469
89.11
523.47
471.39
1875.13
750.57

4012
81.23
1137.93
352.70
702.11
303.50

14003
85.48
588.35
140.53
940.91
244.68

25550
81.11
130.44
21.18
99.94
23.47

1684
89.47
788.73
736.74
3493.87
1629.14

25705
78.67
608.91
95.39
477.51
114.34

24770
76.96
124.63
58.14
244.33
107.12

24843
80.63
1529.74
555.96
2719.25
1061.12

45
78.37
97.82
39.87
173.04
76.68

245
81.08
30.84
10.46
51.23
15.00

24821
82.27
34.36
7.77
54.32
19.77

1401
77.33
69.28
14.03
52.22
17.29

1962
78.25
44.77
12.65
26.15
23.39

1246
82.94
37.24
17.41
82.08
35.89

19112
83.49
227.09
41.26
162.45
41.41

21542
81.48
75.73
11.78
53.64
19.14

20082
86.48
84.34
9.94
66.36
28.45

15237
79.22
243.57
60.93
168.46
37.30

15299
77.05
115.51
45.17
75.17
56.24

15364
77.24
77.86
12.53
102.74
36.36

2812
79.92
250.95
52.91
182.78
42.75

15642
79.43
574.29
92.23
434.05
119.62

17829
92.65
759.68
633.86
2726.68
1360.50

573
77.61
1599.70
404.19
2608.86
1776.16

13004
78.85
174.31
28.36
131.55
40.25

23884
80.38
55.79
14.99
30.14
28.25

1312
79.31
877.80
98.92
1048.20
167.10

1844
79.43
215.94
40.20
163.57
52.46

17274
76.44
77.42
33.89
146.25
65.82

1553
81.63
1952.70
632.62
3812.62
1693.78

247
83.22
78.49
23.83
127.29
32.51

1542
83.19
741.70
151.84
1084.13
306.88

18354
76.71
704.94
297.65
400.28
242.40

15599
81.08
768.89
96.61
962.67
147.01

21575
77.78
452.86
97.04
333.22
68.32

4532
78.31
171.23
78.76
279.78
96.10

21147
77.30
282.41
67.81
361.22
81.20

19110
77.85
342.86
94.88
201.97
95.13

1515
77.63
246.92
46.18
186.59
43.06

18502
79.77
372.75
197.72
765.58
271.46

17154
77.24
245.45
57.67
186.78
60.02

7489
84.90
26.53
14.62
73.20
31.11

18468
81.39
106.55
21.07
77.98
27.23

16091
77.52
20.73
9.39
32.57
13.59

17693
78.46
1038.76
282.54
1505.15
387.40

15576
76.69
520.40
95.90
421.09
93.97

9073
77.63
44.73
15.30
22.89
18.48

17332
83.07
223.62
28.27
303.15
73.10

18887
76.75
165.20
20.55
143.02
37.45

16168
82.94
544.90
152.30
363.58
234.93

3886
76.75
74.47
22.33
42.38
20.96

19222
77.73
563.31
40.36
635.63
111.62

23505
81.63
790.51
196.75
566.19
124.65

21140
78.79
125.03
91.50
108.35
40.63

21766
83.55
202.85
35.26
284.66
63.71

21462
79.31
332.31
60.15
254.18
55.30

1685
85.14
1891.26
1942.12
8508.70
4812.11

6691
80.35
119.49
85.12
119.56
46.57

5129
85.32
88.98
34.42
179.18
56.59

20866
78.89
654.18
82.36
778.30
119.91

2702
80.11
352.18
62.63
280.79
90.45

24051
82.30
75.09
17.26
113.95
26.52

11324
79.74
567.08
75.40
686.26
133.81

21339
82.63
81.54
44.75
34.07
19.67

2782
79.00
413.70
142.88
205.21
80.64

24109
89.60
75.68
42.47
221.62
99.80

19358
80.77
230.36
276.27
811.89
308.44

16521
78.64
378.70
73.70
284.05
76.53

3941
80.35
312.71
52.90
243.38
62.94

17832
83.19
522.94
599.21
1979.69
796.76

2242
80.13
1529.47
425.16
2188.74
547.68

7278
83.62
1079.66
205.71
1408.78
288.29

7681
80.90
141.52
29.83
104.60
44.18

16169
84.14
336.78
145.47
178.83
293.41

12846
79.68
27.13
8.38
43.38
16.45

9439
79.37
715.53
238.18
1099.47
279.57

3713
80.93
785.80
153.20
1070.46
218.25

14638
80.72
103.18
17.90
77.40
20.36

3610
82.03
734.56
248.13
1122.80
330.52

17743
84.44
74.48
35.97
103.03
28.16

17234
80.44
450.62
66.65
591.69
138.75

20918
79.25
568.16
114.17
403.50
84.82

15393
81.33
222.37
28.91
286.78
51.31

4291
80.53
163.79
60.20
282.61
88.79

18681
81.30
388.94
53.06
282.82
72.56

17887
79.25
984.05
226.20
1384.89
288.41

6059
79.07
132.38
25.33
187.49
43.92

18996
83.22
175.14
36.61
124.78
29.81

8445
78.64
50.64
6.93
39.43
18.79

1687
84.65
544.45
532.83
1797.73
696.06

19188
80.32
899.58
236.54
1310.91
334.70

9035
79.04
153.86
24.05
125.62
27.03

21648
81.57
298.40
58.99
208.18
69.29






























































































































































TABLE 5K





TUBULAR OBSTRUCTION



Att. Docket No. GENE-077/26US

Doc. No. 44941











Tox
Non-Tox
Non-Tox

GLGC

Tox Group
Group
Group
Group

Identifier
LDA Score
Mean
SD
Mean
SD










3125
97.51
134.07
16.15
301.07
82.87

24321
97.03
278.42
73.76
654.31
157.88

16172
97.00
196.13
57.63
438.64
92.11

11157
97.36
381.78
35.68
622.92
138.68

14120
95.69
344.76
63.42
681.34
196.77

7804
97.51
960.98
105.31
1652.52
334.35

6416
98.21
579.40
132.32
123.67
88.39

14677
96.97
173.50
38.06
69.76
30.14

22213
96.85
343.29
29.34
220.99
47.39

15004
98.36
1003.54
557.03
153.76
135.69

7307
97.33
78.43
11.40
28.42
17.35

24388
96.91
366.07
61.09
177.80
66.28

23076
95.88
225.13
23.27
126.52
43.88

14600
97.67
377.21
86.43
184.44
47.39

16518
97.39
1674.58
199.69
953.13
316.63

17735
94.00
260.66
25.70
179.21
105.51

15850
92.48
1864.12
172.78
1413.57
279.10

10241
97.00
135.36
24.60
59.08
23.90

15297
94.24
235.35
26.33
147.28
40.80

17736
92.57
156.31
28.57
69.99
158.10

1453
95.30
123.25
24.55
52.01
26.39

1454
95.27
243.07
44.54
107.34
52.73

25064
95.88
1945.50
256.26
1121.25
327.07

13723
95.97
1591.34
343.04
844.53
377.73

2629
92.97
126.65
56.54
22.18
24.99

20457
96.85
203.76
31.70
396.48
99.84

4234
92.87
227.21
26.55
368.61
110.36

25198
97.09
72.42
16.64
27.14
14.63

10015
96.85
467.24
95.91
230.34
82.57

2368
94.72
338.76
47.77
623.40
131.64

1214
94.88
67.47
15.18
153.85
51.68

968
95.42
28.67
11.78
81.24
22.91

17159
98.15
1500.61
126.72
787.85
215.88

574
97.85
1110.83
280.01
349.51
177.04

20458
95.48
190.71
40.37
368.84
96.93

8829
97.57
506.29
44.16
283.09
85.65

7196
98.06
534.14
57.92
176.74
89.27

1460
96.69
382.75
102.15
191.62
82.76

25546
94.39
236.19
103.10
500.97
150.34

1472
92.75
84.81
22.82
179.09
72.56

20884
96.88
157.01
69.56
737.17
291.54

20848
98.67
1124.03
59.72
548.54
158.49

25747
98.48
177.09
33.14
42.07
35.81

19824
94.72
96.00
24.52
215.81
73.19

25802
94.94
793.44
106.90
521.62
118.73

24496
98.09
30.75
7.27
111.42
36.91

457
98.36
766.78
198.11
285.03
90.56

18074
94.97
109.26
17.39
48.61
23.99

14970
96.85
103.48
14.71
199.88
40.65

1809
98.03
551.79
225.15
32.34
127.23

645
96.42
46.88
15.03
135.75
49.83

17473
96.51
693.48
64.78
442.45
103.23

20983
96.51
56.90
15.12
137.12
56.79

1501
98.15
248.82
53.21
51.72
53.85

4449
93.57
129.63
26.81
243.37
70.00

15002
98.24
640.78
258.49
133.14
98.70

15003
98.33
555.22
226.49
31.19
86.19

4235
96.03
655.06
64.01
411.65
95.74

20828
96.82
843.23
197.75
322.31
161.39

7197
98.06
552.05
97.28
187.97
84.72

14989
94.54
784.37
97.84
533.89
115.84

24649
92.66
80.76
6.94
112.06
23.19

21653
92.66
435.18
92.53
237.04
66.87

20126
92.54
206.98
53.24
75.61
46.32

23651
97.33
2999.14
682.81
737.32
670.73

20885
97.06
196.55
50.26
589.85
226.42

24563
97.73
53.16
51.89
321.95
111.13

24564
97.79
141.81
78.70
614.84
191.71

19040
98.36
746.18
87.47
181.80
113.32

20816
93.24
1045.14
268.49
407.56
184.26

15540
93.45
116.06
52.11
33.92
19.17

1824
92.72
58.52
11.62
110.12
31.28

2010
94.21
280.66
119.92
31.78
286.73

19712
94.12
38.70
9.79
84.74
26.43

12606
98.36
139.84
17.95
295.27
98.40

1970
93.12
395.31
97.34
159.82
57.55

20481
93.94
123.57
15.86
201.41
41.25

405
94.48
122.46
18.09
208.02
63.59

1463
97.48
1492.64
275.86
664.70
314.91

20849
92.82
517.85
86.60
281.86
89.61

646
94.72
210.57
63.36
527.32
192.98

1993
93.48
86.65
13.28
24.00
17.68

15032
97.03
98.00
17.89
265.50
73.53

24643
95.30
22.65
15.29
92.91
36.14

1510
93.94
410.93
156.67
839.46
222.78

1564
94.03
1045.96
352.70
42.41
190.11

2465
94.75
74.41
17.98
131.77
26.88

20582
98.21
294.34
14.97
487.80
95.06

23033
95.24
416.40
24.35
579.36
117.73

15833
95.39
347.90
22.55
491.39
86.11

9905
94.97
409.12
110.92
745.80
152.14

17249
93.63
662.67
98.62
1014.19
206.07

2576
92.78
43.64
15.68
84.39
23.87

17933
96.27
250.36
25.67
394.80
75.13

2107
95.94
286.61
18.41
438.00
95.36

13610
96.30
183.04
38.90
365.50
106.63

18275
97.21
161.22
17.79
261.59
56.25

20088
96.00
216.81
25.74
391.74
86.08

23783
92.87
303.32
50.24
456.35
79.84

12848
93.39
278.64
36.68
431.16
92.63

3438
92.81
157.80
81.72
149.25
39.94

14465
93.69
22.00
7.12
55.40
19.66

3853
94.00
89.36
14.28
154.56
34.31

13332
96.12
184.35
54.35
438.90
102.70

17800
93.81
115.79
18.77
196.78
42.92

23063
93.30
242.82
57.21
390.31
77.53

22910
94.33
205.38
23.87
311.27
55.99

17494
94.24
137.15
20.45
216.68
41.79

21072
93.88
97.50
27.28
199.81
51.39

17325
98.03
521.47
220.14
55.89
101.96

21165
98.33
169.51
57.41
28.30
24.49

21166
97.94
715.26
183.98
263.82
92.19

22631
97.57
1970.17
341.41
1035.66
227.87

22536
98.15
3172.12
437.63
1609.00
403.10

17477
98.03
241.66
34.05
111.41
35.04

4944
97.51
322.82
51.74
119.57
56.74

23123
98.54
948.44
137.32
316.83
113.69

17363
96.21
639.82
80.77
1037.93
191.02

5205
96.18
86.34
21.51
204.18
49.25

2563
97.12
270.81
32.33
158.90
37.75

2569
96.85
169.84
58.46
421.57
98.69

16394
97.42
1770.55
477.74
595.39
336.14

3121
97.79
435.91
101.84
1290.92
319.95

10532
97.54
194.55
35.06
100.22
29.27

15089
96.54
343.46
36.17
177.01
69.57

6842
98.00
214.44
33.38
110.48
29.69

18657
97.67
817.51
100.75
432.51
105.51

3995
95.85
316.65
57.49
606.04
143.87

21796
97.54
1253.95
159.97
690.15
198.29

3493
97.63
123.77
18.10
61.40
17.94

22592
98.33
743.64
93.52
227.11
172.72

15928
96.73
360.97
86.20
159.46
54.19

21391
97.39
491.14
76.01
218.82
131.14

9212
95.94
1468.88
150.78
909.30
234.39

21797
97.12
684.25
148.72
331.98
107.52

14142
96.57
126.88
24.18
75.34
18.27

7414
96.48
301.62
37.09
183.56
50.38

19991
96.66
169.60
23.54
342.07
85.80

16885
96.12
481.97
76.93
847.27
179.62

17221
97.03
228.07
58.62
528.15
137.97

14929
98.39
2578.08
443.16
753.00
395.31

2534
97.03
70.98
11.01
35.47
11.17

22626
98.06
466.77
115.62
84.66
75.68

15146
98.61
552.75
212.61
125.29
66.30

15964
97.03
389.05
102.49
1091.29
283.24

15879
97.09
195.88
18.98
348.95
67.27

7892
95.72
197.94
41.59
93.14
62.88

12551
97.39
81.94
8.91
164.20
42.11

18528
96.97
806.92
124.34
361.09
159.22

18529
98.00
501.19
67.11
190.38
73.93


























































































































































































TABLE 5L





NSAIDS



Atty. Docket No. GENE-077/26US

Doc. No. 44941











Tox
Non-Tox
Non-Tox

GLGC

Tox Group
Group
Group
Group

Identifier
LDA Score
Mean
SD
Mean
SD










18678
84.72
196.91
72.64
100.06
53.79

24321
87.93
413.07
112.27
654.29
158.97

19509
82.73
48.13
11.49
80.75
26.24

14131
82.63
69.28
24.69
33.77
24.51

6046
83.07
101.90
48.10
194.33
61.90

14677
82.70
123.20
43.11
69.90
30.74

17950
82.75
89.75
11.67
61.68
19.97

8759
86.16
246.43
53.78
156.18
40.90

6431
82.62
132.49
55.91
49.83
28.54

13615
90.34
398.90
85.87
240.22
52.84

15666
82.57
1060.02
522.22
2855.82
1671.25

15667
83.51
1304.24
352.22
2487.79
1225.01

13091
80.48
52.53
22.18
93.54
32.42

13092
79.97
78.72
26.06
126.13
38.28

15446
83.46
502.42
69.06
388.27
92.25

20711
84.95
140.70
71.44
33.55
34.91

1857
82.73
341.51
97.88
203.31
63.37

20801
80.39
235.97
71.05
150.06
48.11

21014
83.22
324.17
132.01
148.40
78.26

20713
88.19
613.63
263.40
208.35
112.71

4749
80.02
382.14
128.89
229.43
180.48

343
79.15
86.27
53.27
26.04
28.49

15409
80.33
650.73
204.15
413.05
118.78

4290
79.94
131.21
41.46
84.46
26.82

1858
82.64
264.03
71.62
153.29
49.94

20714
85.62
475.80
301.89
167.76
86.41

20457
79.40
282.98
97.45
396.37
100.16

18300
87.44
220.58
102.85
486.89
169.94

19665
78.87
164.53
59.70
88.19
51.24

23868
78.20
339.24
209.69
170.18
283.60

23679
81.96
67.13
19.94
38.29
19.93

20404
80.43
94.71
35.90
45.29
43.92

15535
84.79
635.56
107.51
476.52
79.47

3254
79.68
261.62
54.46
188.01
48.62

28
80.08
305.95
229.49
532.06
179.36

24219
79.60
487.67
128.97
321.74
100.36

20458
79.76
244.63
78.16
368.93
97.12

24566
81.55
61.11
42.07
180.55
89.38

25453
78.35
158.39
37.24
209.35
50.63

15137
79.56
1740.58
785.79
1800.11
446.41

1943
79.66
47.96
16.20
25.73
11.95

23869
81.20
68.78
38.38
35.67
78.90

2153
80.16
416.39
243.57
174.99
148.74

20715
84.77
296.44
124.89
126.05
58.80

18352
78.40
338.81
174.54
155.29
86.17

24438
82.21
98.87
20.24
143.39
40.54

45
78.36
76.12
49.26
173.08
76.39

16610
80.56
243.87
59.82
165.05
65.89

9541
80.05
434.33
105.00
293.71
104.56

1804
81.93
1429.11
390.65
3161.94
1771.85

18713
79.36
381.95
48.08
304.10
71.82

4235
79.08
495.44
76.22
412.41
97.43

7197
79.60
330.86
107.57
188.93
88.45

21975
84.94
342.10
74.80
211.95
62.48

15191
85.85
2673.45
2339.47
2414.85
1220.31

17516
84.12
769.10
139.21
544.65
126.18

8212
80.98
2755.24
1630.16
2776.64
1026.95

13004
80.46
212.11
74.18
131.27
39.09

17357
82.25
167.86
96.71
269.67
96.37

20925
78.68
466.02
114.97
342.39
120.38

21443
81.12
204.24
81.36
91.06
49.71

21654
86.49
610.80
129.78
376.37
127.86

16775
84.32
572.11
282.27
1168.56
397.36

1977
78.29
187.70
37.39
133.15
38.47

16681
81.28
120.46
46.82
63.39
25.75

16552
82.19
106.93
35.18
162.92
41.40

21147
82.43
260.55
45.69
361.25
81.16

1422
81.09
170.29
61.30
300.89
105.05

15032
81.50
153.02
48.41
265.54
73.91

17394
78.25
484.34
116.34
347.89
115.27

22321
82.42
175.73
62.89
94.40
68.17

15411
91.34
532.28
101.56
303.52
93.15

21683
84.77
83.44
41.31
26.99
20.17

16520
80.98
273.60
150.69
86.32
98.04

7489
78.33
30.74
20.35
73.04
31.19

1894
87.01
371.06
120.65
196.88
70.39

1597
84.01
141.64
66.96
42.68
38.09

16476
83.27
533.78
102.18
788.60
304.36

16982
88.41
872.27
500.25
127.82
293.88

23166
87.07
254.30
83.26
126.36
61.00

16312
80.12
102.23
41.22
49.22
37.54

15421
78.89
574.98
96.06
739.12
153.32

24472
78.43
185.77
62.80
235.91
53.31

16446
81.63
26.33
5.45
37.15
10.18

18269
84.55
548.35
110.14
772.70
179.32

20522
82.48
341.19
119.99
166.57
84.98

20523
78.29
867.83
225.50
579.11
163.88

17088
82.59
92.61
16.98
58.41
31.43

14595
92.40
158.58
45.64
77.34
33.09

12276
78.61
103.82
42.09
187.47
61.18

20961
78.19
20.76
3.97
29.87
11.94

21125
82.76
96.85
28.42
152.75
47.47

4661
95.47
517.39
93.47
306.62
84.32

21354
88.97
645.15
137.68
417.97
125.69

12673
82.79
90.29
25.44
40.47
22.14

14763
87.65
304.65
189.03
37.13
142.64

17477
84.19
180.63
52.28
111.57
35.73

23978
83.49
74.40
21.67
112.19
29.95

22479
92.04
716.72
125.18
416.64
126.59

5183
86.42
320.31
60.86
221.48
61.55

5295
83.12
408.06
135.30
217.58
80.67

2457
84.67
464.90
167.87
288.94
67.89

11324
83.67
525.31
77.71
686.40
133.36

21339
84.46
79.78
30.57
34.21
20.21

3020
85.38
424.83
78.70
293.70
77.59

22737
85.25
409.70
157.83
207.21
89.14

22698
87.20
115.27
56.59
268.84
120.86

6833
82.80
96.02
13.68
73.52
18.72

22619
88.03
501.19
81.50
363.98
67.50

16521
87.65
508.30
116.48
282.94
73.28

15679
84.16
286.66
65.08
173.83
46.74

24200
87.65
819.79
161.12
425.21
136.58

7471
82.90
308.76
49.66
224.13
54.98

6758
83.67
60.74
21.52
28.80
13.40

7299
97.84
646.85
211.22
178.29
134.95

7451
82.91
502.98
103.58
367.08
83.19

23712
83.36
224.13
38.61
157.15
38.03

7540
97.93
486.02
138.76
157.21
80.71

8065
85.15
225.82
45.65
163.47
35.91

8202
84.27
377.45
72.53
277.16
54.79

8820
82.74
530.25
320.31
138.57
119.39

24197
84.17
107.40
60.94
236.21
79.34

19031
85.24
118.24
42.75
59.90
50.43

9026
82.73
109.55
35.12
60.22
26.27

9583
85.07
208.74
101.61
55.02
59.66

11057
85.12
96.32
38.40
34.75
28.49

15538
85.56
293.17
36.37
218.71
56.03

12921
90.13
225.68
80.44
101.95
47.41

19011
82.51
487.88
60.90
393.64
86.49

12979
89.28
754.80
237.57
364.95
194.44

4119
85.47
162.78
28.48
109.13
32.45

1807
84.08
1593.11
543.91
4019.95
2715.05

21956
82.63
206.97
23.50
163.56
37.58

22103
86.70
364.57
103.66
219.40
53.63

13310
87.15
232.04
61.40
124.22
68.91

15964
91.55
539.50
171.88
1092.30
283.63

14425
82.88
332.80
79.03
203.82
68.76

13614
94.20
559.10
110.65
323.06
68.04

23151
91.91
200.64
48.10
356.08
100.63

6102
86.24
198.65
25.41
143.71
30.86